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2003 IEEE Nuclear Science Symposium. Conference Record (IEEE Cat. No.03CH37515)最新文献

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Adaptive signal processing with genetic algorithm optimum filter for fast digitizer ASIC 基于遗传算法的快速数字化专用集成电路自适应信号处理
Pub Date : 2003-10-19 DOI: 10.1109/NSSMIC.2003.1352652
H. Takahashi, N. Shaaban, Q.W. Wang, J. Yeom, M. Nakazawa
Signal processing for compound semiconductor detectors is one of the main issues for expanding use of moderate grade detectors. Although a peak performance is obtained for the best detector, depending on the process difficulty, many detectors are classified into counter grade or less. If optimum signal processing for such moderate grade detectors is developed, compound semiconductor detectors can be applied to many different fields in radiation measurements. We have taken a very flexible digitizing approach to achieve this aim and now we are trying to develop a dedicated ASIC which includes multiple preamplifiers, variable gain amplifiers, and fast digitizers in one chip. Genetic algorithm is an adaptive optimization technique which can be used in many fields. In this paper we describe an adaptive signal processing method with genetic algorithm for a fast digitizer ASIC.
化合物半导体探测器的信号处理是扩大中等等级探测器使用的主要问题之一。虽然最好的检测器获得了峰值性能,但根据工艺难度,许多检测器被划分为反级或更低。如果对这种中等等级的探测器进行最佳的信号处理,化合物半导体探测器可以应用于许多不同的辐射测量领域。我们采取了非常灵活的数字化方法来实现这一目标,现在我们正在尝试开发一种专用的ASIC,其中包括多个前置放大器,可变增益放大器和一个芯片中的快速数字化器。遗传算法是一种可应用于许多领域的自适应优化技术。本文介绍了一种基于遗传算法的快速数字化ASIC自适应信号处理方法。
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引用次数: 2
Scattering muon radiography and its application to the detection of high-Z materials 散射介子射线照相及其在高z材料检测中的应用
Pub Date : 2003-10-19 DOI: 10.1109/NSSMIC.2003.1351875
K. Borozdin, G. Hogan, C. Morris, W. Priedhorsky, A. Saunders, L. Schultz, M. E. Teasdale
We have proposed a new method for nuclear material contraband detection based on cosmic ray muon radiography. The method is safe, because it does not include the generation of any artificial radiation, but uses naturally produced high-energy muons. Results obtained with our prototype experiment, and from simulations demonstrate the feasibility of the method for the detection of high-Z materials hidden inside different types of ordinary cargo. Detector technology for muon detection is mature and enables cost-effective design for a muon radiography apparatus. Image reconstruction is not trivial and may be done in various ways. We developed the PoCA algorithm for image reconstruction and the MC (muon crossing) algorithm for the detection of high-Z material. Our simulations of a full-scale muon radiography system suggest high efficiency of detection in 1 minute of exposure with a low number of false positives for a 20 kg of uranium hidden inside 11 tons of uniformly distributed iron.
我们提出了一种基于宇宙射线介子射线成像的核材料违禁品探测新方法。这种方法是安全的,因为它不包括产生任何人工辐射,而是使用自然产生的高能μ子。我们的原型实验和模拟结果表明,该方法对于检测隐藏在不同类型普通货物中的高z材料是可行的。用于μ子探测的探测器技术是成熟的,使设计具有成本效益的μ子射线照相设备成为可能。图像重建不是微不足道的,可以通过各种方式完成。我们开发了用于图像重建的PoCA算法和用于检测高z材料的MC (μ子交叉)算法。我们对全尺寸μ子射线照相系统的模拟表明,对于隐藏在11吨均匀分布的铁中的20公斤铀,在1分钟内的检测效率很高,误报率很低。
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引用次数: 8
Alignment of transmission and emission scans of PET to correct for subject movement using a sinogram consistency criterion 使用正弦图一致性标准校正PET的透射和发射扫描以纠正受试者运动
Pub Date : 2003-10-19 DOI: 10.1109/NSSMIC.2003.1352487
Yu. Chin-Lung, Sung-Cheng Huang, M. Dahlbom, M. Bergsneider
Subject movement leads to misalignment between transmission and emission PET scans acquired at different times. This leads to inaccurate attenuation correction and causes errors in PET images. We propose a new method, which seeks to minimize the variance of the total counts of attenuation corrected emission sinogram among all projection angles. The underlying basis of the method is that if the transmission and emission scans are aligned, the total counts (after attenuation correction) at different projection angles should be equal (i.e., with zero variance). Therefore, by adjusting the spatial transformation parameters between the transmission and emission images to minimize such a variance as a cost function, the two scans would be aligned. The effectiveness of this method is demonstrated in two-dimensional situations with computer simulated data and with a physical phantom PET study.
受试者的运动导致在不同时间获得的透射和发射PET扫描之间的不对齐。这会导致衰减校正不准确,并导致PET图像出现错误。我们提出了一种新的方法,寻求衰减校正发射正弦图的总计数在所有投影角度之间的方差最小。该方法的基础是,如果透射和发射扫描对齐,则不同投影角度的总计数(衰减校正后)应该相等(即零方差)。因此,通过调整透射和发射图像之间的空间变换参数,将这种方差作为代价函数最小化,从而使两次扫描对齐。通过计算机模拟数据和物理幻影PET研究证明了该方法在二维情况下的有效性。
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引用次数: 1
ICA separation of functional components from dynamic cardiac PET data 动态心脏PET数据中功能成分的ICA分离
Pub Date : 2003-10-19 DOI: 10.1109/NSSMIC.2003.1352426
M. Magadán-Méndez, A. Kivimáki, U. Ruotsalainen
The aim of this study was to improve detection of different heart tissues, and specially their boundaries, in H/sub 2//sup 1 5/O PET (positron emission tomography) heart images. This problem was considered as a blind source separation problem. In order to solve it we applied ICA (independent component analysis) on dynamic image data and measured projection profiles (sinograms). The testing was based on two kinds of data: a simple dynamic numerical phantom and human heart data acquired during resting state. The sensitivity of ICA to noise was examined on phantom data, where ICA seemed to be less sensitive to noise on sinogram data than on image data. On cardiac rest data, the results were in line with the results on phantom data.
本研究的目的是提高在H/sub //sup 15 /O PET(正电子发射断层扫描)心脏图像中不同心脏组织的检测,特别是它们的边界。该问题被认为是一个盲源分离问题。为了解决这一问题,我们将ICA(独立分量分析)应用于动态图像数据和测量的投影轮廓(sinogram)。测试基于两种数据:简单的动态数值模拟和静息状态下的人体心脏数据。ICA对噪声的敏感性在幻象数据上进行了检查,其中ICA对正弦图数据的噪声似乎比图像数据的噪声更不敏感。在心脏休息数据上,结果与幻影数据的结果一致。
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引用次数: 15
Estimation of the parameter covariance matrix for a one-compartment cardiac perfusion model estimated from a dynamic sequence reconstructed using MAP iterative reconstruction algorithms 利用MAP迭代重建算法重建动态序列,估计单室心脏灌注模型的参数协方差矩阵
G. Gullberg, R. Huesman, D. G. Ghosh Roy, J. Qi, B. Reutter
In dynamic cardiac SPECT estimates of kinetic parameters of a one-compartment perfusion model are usually obtained in a two step process: 1) first a MAP iterative algorithm, which properly models the Poisson statistics and the physics of the data acquisition, reconstructs a sequence of dynamic reconstructions, 2) then kinetic parameters are estimated from time activity curves generated from the dynamic reconstructions. This paper provides a method for calculating the covariance matrix of the kinetic parameters, which are determined using weighted least squares fitting that incorporates the estimated variance and covariance of the dynamic reconstructions. Sequential tomographic projections are reconstructed into a sequence of transaxial reconstructions for each transaxial slice using for each reconstruction in the time sequence the fixed-point solution to the MAP reconstruction. Time-activity curves for a sum of activity in a blood region inside the left ventricle and a sum in a cardiac tissue region, for the variance of the two estimates of the sum, and for the covariance between the two ROI estimates are generated at convergence. A one-compartment model is fit to the tissue activity curves assuming a noisy blood input function to give weighted least squares estimates of blood volume fraction, wash-in and wash-out rate constants specifying the kinetics for the left ventricular myocardium. Numerical methods are used to calculate the second derivative of the chi-square criterion to obtain estimates of the covariance matrix for the weighted least square parameter estimates. Even though the method requires one matrix inverse for each time interval of tomographic acquisition, efficient estimates of the tissue kinetic parameters in a dynamic cardiac SPECT study can be obtained with present day desk-top computers.
在动态心肌SPECT中,估计单室灌注模型的动力学参数通常分为两步:1)首先使用MAP迭代算法,该算法正确地模拟了泊松统计和数据采集的物理过程,重建了一系列动态重建,2)然后根据动态重建产生的时间活动曲线估计动力学参数。本文提出了一种计算动力学参数协方差矩阵的方法,该方法采用加权最小二乘拟合方法,结合动力学重构的估计方差和协方差确定动力学参数。序列层析投影被重建为每个跨轴切片的跨轴重建序列,对时间序列中的每个重建使用MAP重建的不动点解。在收敛处生成左心室内血液区域和心脏组织区域的活动总和的时间-活动曲线,和的两个估计的方差,以及两个ROI估计之间的协方差。假设一个嘈杂的血液输入函数,一个单室模型适合于组织活性曲线,以给出血容量分数、洗入和洗出速率常数的加权最小二乘估计,指定左心室心肌的动力学。采用数值方法计算卡方准则的二阶导数,得到加权最小二乘参数估计的协方差矩阵的估计。尽管该方法需要对断层成像的每个时间间隔进行一个矩阵逆,但在动态心脏SPECT研究中,组织动力学参数的有效估计可以用目前的台式计算机获得。
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引用次数: 4
Performance evaluation of the channelized Hotelling observer using bootstrap list-mode PET studies 利用自举表模式PET研究信道化Hotelling观测器的性能评价
Pub Date : 2003-10-19 DOI: 10.1109/NSSMIC.2003.1352402
C. Groiselle, Y. D’Asseler, H. Gifford, S. Glick
This study investigated whether list-mode PET data generated using the bootstrap method can be used to predict lesion detectability as assessed by the channelized Hotelling observer (CHO). A Monte-Carlo simulator was used to generate 2D PET list-mode data set acquisitions of a disk object. One of these list-mode sets was then used to create an ensemble of bootstrap list-mode sets. A randomly positioned signal (lesion) was introduced into half of the list-mode sets to create an ensemble of signal-present and signal-absent list-mode sets. These sets were then reconstructed using the OSEM list-mode algorithm. The CHO was computed from the ensemble of reconstructed images generated from the bootstrap data sets as well as from independent noisy data sets. The F-test and the student t-test found no significant difference (confidence level 5%) in the areas under the LROC curve generated using the independent noisy list-mode sets and the bootstrap list-mode sets for clinical count levels. It is also shown how bootstrap images can be used to implement a patient-specific, CHO-based stopping-rule criterion for ordered-subset expectation-maximization (OSEM) list-mode iterative reconstruction. An example of applying the CHO-based stopping-rule criterion for list-mode reconstruction of the MCAT phantom showed an optimal detectability index at iterations 7 using 2 subsets respectively. Results from this study suggest that the bootstrap approach can be used to conduct numerical observer studies with more realistic backgrounds by generating them from a patient study (with the introduction of simulated lesions), and allows the possibility of applying a patient-specific, CHO-based stopping-rule criterion for list-mode iterative reconstruction.
本研究探讨了使用自举法生成的列表模式PET数据是否可以用于预测由通道化Hotelling观测器(CHO)评估的病变可检测性。利用蒙特卡罗模拟机生成磁盘对象的二维PET表模数据集采集。然后使用其中一个列表模式集来创建一个引导列表模式集的集合。将随机定位的信号(病变)引入到一半的列表模式集合中,以创建信号存在和信号不存在的列表模式集合。然后使用OSEM列表模式算法重建这些集合。CHO是根据自举数据集和独立噪声数据集生成的重建图像的集合计算的。f检验和学生t检验发现,使用独立噪声列表模式集和自举列表模式集生成的LROC曲线下的区域没有显著差异(置信水平为5%)。还展示了如何使用引导图像来实现有序子集期望最大化(OSEM)列表模式迭代重建的特定于患者的、基于cho的停止规则标准。将基于cho的停止规则准则应用于MCAT幻影的列表模式重建的实例表明,在迭代7时分别使用2个子集获得了最优的可检测性指标。本研究的结果表明,自举方法可以通过从患者研究(引入模拟病变)中生成具有更真实背景的数值观察者研究,并允许应用针对患者的、基于cho的停止规则准则进行列表模式迭代重建。
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引用次数: 4
The effect of direct x-ray on CMOS APS imager for industrial application 工业应用中直接x射线对CMOS APS成像仪的影响
Pub Date : 2003-10-19 DOI: 10.1109/NSSMIC.2003.1351961
K. H. Kim, G. Cho
In this paper, we presented the effect of direct X-ray after scintillator on the CMOS APS imager using modulation transfer function (MTF), noise power spectrum (NPS), and detective quantum efficiency (DQE). 50 kVp of X-ray tube voltage at the SID of 300 mm were set with continuous made micro-focus X-ray machine on the assumption for industrial application such as PCB inspection. Lanex screen coupled CMOS APS imager was irradiated for long-term. From the experimental results, MTF and also DQE were degraded exponentially because of reduction of dynamic range caused by dark current or dark signal increase. For a given scintillator and an exposure condition, the degradation of image performance can be expected in case that the CMOS APS be used as a basic sensor array.
本文利用调制传递函数(MTF)、噪声功率谱(NPS)和探测量子效率(DQE)分析了直接x射线后闪烁体对CMOS APS成像仪的影响。假设PCB检测等工业应用,采用连续制造微聚焦x射线机,在300mm的SID处设置50 kVp的x射线管电压。Lanex屏幕耦合CMOS APS成像仪长期辐照。从实验结果来看,暗电流或暗信号增加导致动态范围减小,MTF和DQE呈指数级下降。在给定的闪烁体和曝光条件下,使用CMOS APS作为基本传感器阵列会导致图像性能下降。
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引用次数: 3
Electric field-induced birefringence measurements in nuclear detector materials using transmission two-modulator generalized ellipsometry (2-MGE) 利用透射双调制器广义椭圆偏振(2-MGE)测量核探测材料的电场感应双折射
Pub Date : 2003-10-19 DOI: 10.1109/NSSMIC.2003.1352680
G. Jellison
It is well-known that internal electric fields can alter the refractive index of certain materials via the Pockels effect. Using the traditional crossed polarizer configuration, this effect has been used to explore internal electric fields in several materials of interest as potential room temperature nuclear detectors. Recently we have shown that the two-modulator generalized ellipsometer (2-MGE) can be configured in the transmission mode, where it measures the retardation, the direction of the principal axis, the diattenuation, and the polarization factor. Therefore, the transmission 2-MGE provides more information and is more accurate than the crossed polarizer configuration. Utilizing various optical schemes, one can sequentially "map" these parameters for a sample. Examples of electric-field-induced birefringence are presented for crystals of LiNbO/sub 3/ and CZT.
众所周知,内部电场可以通过波克尔斯效应改变某些材料的折射率。使用传统的交叉偏振器配置,这种效应已被用于探索内部电场的几种感兴趣的材料作为潜在的室温核探测器。最近,我们已经证明了双调制器广义椭偏仪(2-MGE)可以配置在传输模式下,它可以测量延迟、主轴方向、双衰减和偏振系数。因此,传输2-MGE提供了更多的信息,比交叉极化配置更准确。利用各种光学方案,可以依次“映射”样品的这些参数。给出了LiNbO/ sub3 /和CZT晶体的电场诱导双折射的例子。
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引用次数: 1
Finger doses received during /sup 18/FDG injections calculated with Monte Carlo simulations 在/sup 18/FDG注射过程中,手指接受的剂量用蒙特卡罗模拟计算
Pub Date : 2003-10-19 DOI: 10.1109/TNS.2004.832574
C. Cordeiro, A. Maio, L. González, A. Gomes
The main objective of this work is to evaluate the absorbed doses in the fingers of PET physicians derived from the administration of /sup 18/FDG, using the Geant3 Monte Carlo code. A comparison is made with data obtained with thermoluminiscent dosimeters. The administration of a PET radiopharmaceutical such as /sup 18/FDG presents a radiation hazard to the hands and fingers. One motivation for this study is the increased use of PET imaging in nuclear medicine that was not followed by a parallel development in the respective dose measurements and optimisation. Considering a workload of 10 patients per week, each medical doctor receives finger doses 3 times lower than the weekly skin dose limit with the fingers in the active volume and 10 times lower if they are in the rear end of the syringe. In the calculations it is assumed that a typical administered activity is 0.185 GBq with a finger-syringe contact time of 10 s. Monte Carlo calculations were performed for different kinds of syringes and different injected volumes. We have also calculated finger doses as a function of the wall thickness for three kinds of wall materials. Results show a slight dose reduction when the polypropylene syringe is replaced by a pyrex one and could be used to derive guidelines for the handling of syringes containing the most used PET radiopharmaceuticals.
这项工作的主要目的是利用Geant3蒙特卡罗代码,评估PET医生手指中因使用/sup 18/FDG而产生的吸收剂量。并与热释光剂量计所得数据作了比较。使用PET放射性药物,如/sup 18/FDG,对手和手指有辐射危害。这项研究的一个动机是PET成像在核医学中的应用越来越多,而在相应的剂量测量和优化方面却没有相应的发展。考虑到每周10个病人的工作量,每个医生接受的手指剂量比每周皮肤剂量限制低3倍,如果手指在活动体积内,则低10倍。在计算中,假设典型的给药活动为0.185 GBq,手指注射器接触时间为10 s。对不同种类的注射器和不同的注射体积进行了蒙特卡罗计算。我们还计算了手指剂量作为三种壁材壁厚的函数。结果显示,当聚丙烯注射器被耐热塑料注射器取代时,剂量略有减少,并可用于制定含有最常用PET放射性药物的注射器的处理指南。
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引用次数: 2
Analytical model for Solstice detector response 夏至探测器响应的解析模型
Pub Date : 2003-10-19 DOI: 10.1109/NSSMIC.2003.1352564
M. Koole, S. Staelens, S. Vandenberghe, Y. D’Asseler, R. Van de Walle, I. Lemahieu
A theoretical formulation of the effective point spread function of a slat collimator on a strip detector has been derived. The used technique is based on the geometric response function of a single gap and it accurately describes the performance of the collimation system. Valuable conclusions on the sensitivity and the spatial resolution of the imaging system could be made. We found that the sensitivity was dependent on the angle of incidence and on the distance to the detector. The spatial resolution was constant in a plane at a fixed distance to the detector. These results were confirmed by the appropriate Monte Carlo simulations. The presented formulation of the geometric response function will be useful with iterative reconstruction algorithms.
导出了条形探测器上板条准直器的有效点扩展函数的理论表达式。该方法基于单间隙的几何响应函数,能准确地描述准直系统的性能。在成像系统的灵敏度和空间分辨率方面得出了有价值的结论。我们发现灵敏度取决于入射角和到探测器的距离。在距离探测器一定距离的平面上,空间分辨率是恒定的。这些结果被适当的蒙特卡罗模拟所证实。所提出的几何响应函数的公式对于迭代重建算法是有用的。
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引用次数: 1
期刊
2003 IEEE Nuclear Science Symposium. Conference Record (IEEE Cat. No.03CH37515)
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