Introduction: Acute drug intoxications are a serious problem worldwide. The damage to the cardiovascular system is severe and sometimes refractory to standard resuscitation therapy. In recent years, interest has increased in the role of lipid emulsions (LEs) as a potential antidote in patients with severe myocardial damage caused by toxic doses of lipophilic drugs. Aims: Clinical analysis of the cardioprotective effects of applied LEs at the Clinic of Toxicology at the Naval Hospital-Varna, Military Medical Academy-Sofia, as an antidote for the treatment of some acute poisoning with a cardiotoxic syndrome. Materials and Methods: The subject of the study were 26 patients with acute cardiotoxic lipophilic drug intoxications treated with LEs at the Clinic of Toxicology at the Naval Hospital-Varna in the period 2016-2018. Illnesses and medications administered to patients are derived from the medical documentation. Results: A three-year study was conducted in patients with acute exogenous intoxications treated with LEs at the Clinic of Toxicology at the Naval Hospital-Varna in regard to their demographics, concomitant diseases and prescribed treatment during their stay. Rapid recovery of patients' vital signs, short hospital stay and lack of adverse effects of LE administration were found. Conclusion: The good clinical results obtained by us will help the implementation of LE in a number of lipophilic intoxications causing toxic cardiovascular damages, including those with hemodynamic instability.
{"title":"Lipid emulsions in the treatment of acute poisoning in the Clinic of Toxicology at the Naval Hospital-Varna, Military Medical Academy-Sofia","authors":"G. Kehayova, S. Zlateva, P. Marinov","doi":"10.14748/SSP.V5I2.5625","DOIUrl":"https://doi.org/10.14748/SSP.V5I2.5625","url":null,"abstract":"Introduction: Acute drug intoxications are a serious problem worldwide. The damage to the cardiovascular system is severe and sometimes refractory to standard resuscitation therapy. In recent years, interest has increased in the role of lipid emulsions (LEs) as a potential antidote in patients with severe myocardial damage caused by toxic doses of lipophilic drugs. Aims: Clinical analysis of the cardioprotective effects of applied LEs at the Clinic of Toxicology at the Naval Hospital-Varna, Military Medical Academy-Sofia, as an antidote for the treatment of some acute poisoning with a cardiotoxic syndrome. Materials and Methods: The subject of the study were 26 patients with acute cardiotoxic lipophilic drug intoxications treated with LEs at the Clinic of Toxicology at the Naval Hospital-Varna in the period 2016-2018. Illnesses and medications administered to patients are derived from the medical documentation. Results: A three-year study was conducted in patients with acute exogenous intoxications treated with LEs at the Clinic of Toxicology at the Naval Hospital-Varna in regard to their demographics, concomitant diseases and prescribed treatment during their stay. Rapid recovery of patients' vital signs, short hospital stay and lack of adverse effects of LE administration were found. Conclusion: The good clinical results obtained by us will help the implementation of LE in a number of lipophilic intoxications causing toxic cardiovascular damages, including those with hemodynamic instability.","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114808390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Kolev, Pavlina Koseva, Mihail K Marinov, G. Alexieva, V. Strashilov
Introduction: A new experimental quantitative approach for evaluating iodine content in organoiodine compounds has been proposed, based on the quartz crystal microbalance (QCM) method. This approach relies on following the time behavior of the resonance frequency of the quartz plate under temperature activation of iodine-containing analyte deposited on its surface. Materials and Methods: We have applied the QCM method and the pharmacopoeial titrimetric method. Results and Conclusion: From the mass variations observed, the quantity of emitted iodine is precisely obtained, which readily delivers its initial content in the studied sample. The obtained value corresponds exactly to the theoretical prediction, in contrast to the value obtained by applying the conventional pharmacopoeial metrics.
{"title":"A quartz crystal microbalance-assisted method for the assessment of iodine content in organoiodines","authors":"I. Kolev, Pavlina Koseva, Mihail K Marinov, G. Alexieva, V. Strashilov","doi":"10.14748/SSP.V5I2.5629","DOIUrl":"https://doi.org/10.14748/SSP.V5I2.5629","url":null,"abstract":"Introduction: A new experimental quantitative approach for evaluating iodine content in organoiodine compounds has been proposed, based on the quartz crystal microbalance (QCM) method. This approach relies on following the time behavior of the resonance frequency of the quartz plate under temperature activation of iodine-containing analyte deposited on its surface. Materials and Methods: We have applied the QCM method and the pharmacopoeial titrimetric method. Results and Conclusion: From the mass variations observed, the quantity of emitted iodine is precisely obtained, which readily delivers its initial content in the studied sample. The obtained value corresponds exactly to the theoretical prediction, in contrast to the value obtained by applying the conventional pharmacopoeial metrics.","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127760341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Myrtenal, a component of many plants` essential oils, is a bicyclic monoterpenoid. Numerous effects of myrtenal in experimental animals have been found - bronchodilatory, anti-inflammatory, anti-aggregative and antihemolytic ( in vitro ), and antibacterial. Its other activities have been studied - antioxidant, antitumor, antihyperglycemic, vasodilating, heart rate reducing and hypotensive. Myrtenal is relatively little studied in the field of neuroscience. Aim : The aim of this article is to summarize the available information on the established biological activity of the monoterpenoid myrtenal. Materials and Methods : Scientific databases such as PubMed, ResearchGate, HMDB and others have been used to provide information on the published results of properties and activities of the test substance (myrtenal) over a period of 15 years (2003 - 2018). Results: Our research confirmed the available data for its central nervous system (CNS) activity - anxiolytic and potentiating the effects of the hypnotic drugs, as well as the antioxidant properties. We have evaluated the neuromodulatory activity of M in brain tissue manifested in elevated levels of major neurotransmitters in healthy rodents and those with neurodegenerative changes accompanied by improvement in the animals` memory. Conclusion : Significant protective effects of myrtenal on neurodegenerative processes were established. Probably they are related to its complex mechanisms, including neuromodulatory and antioxidant properties.
{"title":"A review: Biological activity of myrtenal and some myrtenal-containing medicinal plant essential oils","authors":"S. Dragomanova, L. Tancheva, M. Georgieva","doi":"10.14748/SSP.V5I2.5614","DOIUrl":"https://doi.org/10.14748/SSP.V5I2.5614","url":null,"abstract":"Introduction: Myrtenal, a component of many plants` essential oils, is a bicyclic monoterpenoid. Numerous effects of myrtenal in experimental animals have been found - bronchodilatory, anti-inflammatory, anti-aggregative and antihemolytic ( in vitro ), and antibacterial. Its other activities have been studied - antioxidant, antitumor, antihyperglycemic, vasodilating, heart rate reducing and hypotensive. Myrtenal is relatively little studied in the field of neuroscience. Aim : The aim of this article is to summarize the available information on the established biological activity of the monoterpenoid myrtenal. Materials and Methods : Scientific databases such as PubMed, ResearchGate, HMDB and others have been used to provide information on the published results of properties and activities of the test substance (myrtenal) over a period of 15 years (2003 - 2018). Results: Our research confirmed the available data for its central nervous system (CNS) activity - anxiolytic and potentiating the effects of the hypnotic drugs, as well as the antioxidant properties. We have evaluated the neuromodulatory activity of M in brain tissue manifested in elevated levels of major neurotransmitters in healthy rodents and those with neurodegenerative changes accompanied by improvement in the animals` memory. Conclusion : Significant protective effects of myrtenal on neurodegenerative processes were established. Probably they are related to its complex mechanisms, including neuromodulatory and antioxidant properties.","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130160590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Nikolova, Z. Stoyanov, D. Doncheva, S. Trendafilova
The history of wine use as a medicine dates back to antiquity. However, it has been rediscovered and reliably confirmed by current medical research. It is believed that wine is among the first documented remedies known and used by humans dating back to a period before 5000 BC. Preserved to date evidence of the medical use of wine in ancient times is very limited and is related to the development of different cultures and ancient civilizations. The article chronicles the more important periods of the history of the use of wine for medical (healing and prophylactic) purposes. The first evidence dates back to the time of the Mesopotamian culture, when the world's oldest Sumerian Pharmacopoeia - clay tiles, some of which contain wine prescriptions for therapy, was created. The next important documentary evidence is found in the Sino-Tibetan Pharmacopoeia, the Egyptian Medical Papyri, the Bible, the Sacred Book of the Jews Talmud , and the ancient Indian medical texts of Ayurveda. In ancient Greece, the first evidence of the healing effects of wine is found in the two poems of Homer Iliad and Odyssey . With the development of medical knowledge at the time of Hippocrates, the therapeutic use of wine expanded. Hippocrates included wine in the diet of almost all diseases, especially during the recovery period. Afterwards, the principles of wine therapy continued to be topical, although they were the subject of a heated debate during the Greco-Roman period, Galen's era, and even the Byzantine era, when the influence of Arab medicine began to manifest itself more and more.
{"title":"Wine as a medicine in ancient times","authors":"P. Nikolova, Z. Stoyanov, D. Doncheva, S. Trendafilova","doi":"10.14748/SSP.V5I2.5610","DOIUrl":"https://doi.org/10.14748/SSP.V5I2.5610","url":null,"abstract":"The history of wine use as a medicine dates back to antiquity. However, it has been rediscovered and reliably confirmed by current medical research. It is believed that wine is among the first documented remedies known and used by humans dating back to a period before 5000 BC. Preserved to date evidence of the medical use of wine in ancient times is very limited and is related to the development of different cultures and ancient civilizations. The article chronicles the more important periods of the history of the use of wine for medical (healing and prophylactic) purposes. The first evidence dates back to the time of the Mesopotamian culture, when the world's oldest Sumerian Pharmacopoeia - clay tiles, some of which contain wine prescriptions for therapy, was created. The next important documentary evidence is found in the Sino-Tibetan Pharmacopoeia, the Egyptian Medical Papyri, the Bible, the Sacred Book of the Jews Talmud , and the ancient Indian medical texts of Ayurveda. In ancient Greece, the first evidence of the healing effects of wine is found in the two poems of Homer Iliad and Odyssey . With the development of medical knowledge at the time of Hippocrates, the therapeutic use of wine expanded. Hippocrates included wine in the diet of almost all diseases, especially during the recovery period. Afterwards, the principles of wine therapy continued to be topical, although they were the subject of a heated debate during the Greco-Roman period, Galen's era, and even the Byzantine era, when the influence of Arab medicine began to manifest itself more and more.","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132189464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Stefanova, Siyana Dimova, Y. Eneva, N Arhangelova
This article analyses the content of natural radionuclides in chamomile plants collected from two different locations. Both samples have been dried in the shade at room temperature. The chamomile has been collected in July 2016 from two different regions of Bulgaria - Yagnilo village, Varna district and the village of Debeli Rat, Veliko Tarnovo district. They are dried under natural conditions and milled into a fine powder. The measurements are taken on a low-background spectrometer at Shumen University "Episkop Konstantin Preslavski". The resulting gamma-spectra are processed with ANGES software. Radioisotopes are determined by their energies. The values of their specific activities are calculated. Approximately the same levels of 226 Ra, 228 Ac, 208 T1 and 40 K are found in the samples from both regions. The highest levels of radionuclides are meаsured for 40 K, the lowest specific activity in the flowers from Yagnilo is found for 208 Tl, and in those from Debeli Rat - for 212 Pb. The levels of their specific activities are within the limits, according to Ordinance №25 on the requirements for protection of people in case of chronic irradiation, as a result of production, trade and use of raw materials, products and goods with increased content of radionuclides and Ordinance №11 on defining the terms and conditions for providing free food and/or supplements to the workers and employees who work in enterprises of a specific nature and organization of work. The public health of consumers is not at risk, given these levels.
{"title":"Radionuclide content in Matricaria chamomilla L., grown in two regions","authors":"T. Stefanova, Siyana Dimova, Y. Eneva, N Arhangelova","doi":"10.14748/SSP.V5I2.4517","DOIUrl":"https://doi.org/10.14748/SSP.V5I2.4517","url":null,"abstract":"This article analyses the content of natural radionuclides in chamomile plants collected from two different locations. Both samples have been dried in the shade at room temperature. The chamomile has been collected in July 2016 from two different regions of Bulgaria - Yagnilo village, Varna district and the village of Debeli Rat, Veliko Tarnovo district. They are dried under natural conditions and milled into a fine powder. The measurements are taken on a low-background spectrometer at Shumen University \"Episkop Konstantin Preslavski\". The resulting gamma-spectra are processed with ANGES software. Radioisotopes are determined by their energies. The values of their specific activities are calculated. Approximately the same levels of 226 Ra, 228 Ac, 208 T1 and 40 K are found in the samples from both regions. The highest levels of radionuclides are meаsured for 40 K, the lowest specific activity in the flowers from Yagnilo is found for 208 Tl, and in those from Debeli Rat - for 212 Pb. The levels of their specific activities are within the limits, according to Ordinance №25 on the requirements for protection of people in case of chronic irradiation, as a result of production, trade and use of raw materials, products and goods with increased content of radionuclides and Ordinance №11 on defining the terms and conditions for providing free food and/or supplements to the workers and employees who work in enterprises of a specific nature and organization of work. The public health of consumers is not at risk, given these levels.","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"2014 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129023719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The development of a methodical directional synthesis of complex organic molecules with the aim of obtaining the physiologically active substance with selective action takes a central position in modern synthetic organic chemistry. Imidazole derivatives are a key component in great many bioactive compounds of both natural and synthetic origin. Ðœany scientists in the field of pharmaceutical chemistry and pharmacology have been attracted to them in recent years. This is because of the exceptional chemical properties and biological activities that they demonstrate. It is a big challenge for the scientists to modify and synthesize new imidazole derivatives.
{"title":"Reaction strategies for synthesis of imidazole derivatives: a review","authors":"S. Atanasova-Stamova, S. Georgieva, M. Georgieva","doi":"10.14748/SSP.V5I2.5483","DOIUrl":"https://doi.org/10.14748/SSP.V5I2.5483","url":null,"abstract":"The development of a methodical directional synthesis of complex organic molecules with the aim of obtaining the physiologically active substance with selective action takes a central position in modern synthetic organic chemistry. Imidazole derivatives are a key component in great many bioactive compounds of both natural and synthetic origin. Ðœany scientists in the field of pharmaceutical chemistry and pharmacology have been attracted to them in recent years. This is because of the exceptional chemical properties and biological activities that they demonstrate. It is a big challenge for the scientists to modify and synthesize new imidazole derivatives.","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134058426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Surgical wounds are the most commonly treated wounds in today's global medical practice. Often, patients are not aware of exactly how they should treat their post-surgical wounds at home. A model for pharmaceutical care of patients with postoperative wounds was developed on the basis of literary sources and guidelines. The Life Value (LV) of the patients was evaluated using the generic SF12 v2 instrument. SF12 v2 was administered to consulted patients and not consulted patients in a control group. The results showed an improvement in all measured LV scores within the group of the consulted patients. Pharmacists are the most accessible healthcare professionals and with their knowledge and competencies, they can contribute to the process.
{"title":"Pharmaceutical care for patients with postoperative history","authors":"Nikolina Zarkova, A. Todorova, Ivo Kumanov","doi":"10.14748/SSP.V5I2.5104","DOIUrl":"https://doi.org/10.14748/SSP.V5I2.5104","url":null,"abstract":"Surgical wounds are the most commonly treated wounds in today's global medical practice. Often, patients are not aware of exactly how they should treat their post-surgical wounds at home. A model for pharmaceutical care of patients with postoperative wounds was developed on the basis of literary sources and guidelines. The Life Value (LV) of the patients was evaluated using the generic SF12 v2 instrument. SF12 v2 was administered to consulted patients and not consulted patients in a control group. The results showed an improvement in all measured LV scores within the group of the consulted patients. Pharmacists are the most accessible healthcare professionals and with their knowledge and competencies, they can contribute to the process.","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"127 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127505580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present study deals with the development of a new qualitative electrochemical analytic test for detecting the chemotherapeutic agent Nitrofural . The combination of sodium amminepentacyanoferrate(II) and electric power, provided by a 9V battery, was successfully implemented for the analysis of the medicine in question.
{"title":"Electrochemical detection of Nitrofural in the presence of sodium amminepentacyanoferrate (II)","authors":"I. Kolev, S. Ivanova, Mihail K Marinov","doi":"10.14748/ssp.v5i2.5103","DOIUrl":"https://doi.org/10.14748/ssp.v5i2.5103","url":null,"abstract":"The present study deals with the development of a new qualitative electrochemical analytic test for detecting the chemotherapeutic agent Nitrofural . The combination of sodium amminepentacyanoferrate(II) and electric power, provided by a 9V battery, was successfully implemented for the analysis of the medicine in question.","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"128 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133941301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Marinov, Dobri Ivanov, S. Zlateva, S. Dimitrova, G. Kehayova, M. Radeva, S. Stoeva
Acute intoxications with organophosphorus pesticides (OPs) are a challenge for the clinical toxicology, because they are common, severe and with high lethality. Most OPs are lipophilic. In recent years, intravenous lipid emulsion (ILE) has been successfully used to treat acute poisoning with lipophilic xenobiotics. A clinical case of a 64-year-old male hospitalized after oral intake of 50 ml of fenitrothion is reported. He had been hospitalized with tachypnea and depressed consciousness – 8 by Glasgow coma scale (GCS). Standardized for this type of intoxication treatment was initiated. On the 3rd hour treatment with Intralipid 20% was started, with a bolus dose of 1.5 ml/kg followed by infusion at a rate of 0.25 ml/kg/min to a total dose of 1000 ml. At the 16th hour consciousness was restored to GCS-15. In severe FTO intoxications ILE can be used as an additional method of controlling cardiotoxic and neurotoxic effects.
{"title":"Intravenous lipid emulsion infusion in acute intoxication with fenitrothion","authors":"P. Marinov, Dobri Ivanov, S. Zlateva, S. Dimitrova, G. Kehayova, M. Radeva, S. Stoeva","doi":"10.14748/ssp.v1i1.5108","DOIUrl":"https://doi.org/10.14748/ssp.v1i1.5108","url":null,"abstract":"Acute intoxications with organophosphorus pesticides (OPs) are a challenge for the clinical toxicology, because they are common, severe and with high lethality. Most OPs are lipophilic. In recent years, intravenous lipid emulsion (ILE) has been successfully used to treat acute poisoning with lipophilic xenobiotics. A clinical case of a 64-year-old male hospitalized after oral intake of 50 ml of fenitrothion is reported. He had been hospitalized with tachypnea and depressed consciousness – 8 by Glasgow coma scale (GCS). Standardized for this type of intoxication treatment was initiated. On the 3rd hour treatment with Intralipid 20% was started, with a bolus dose of 1.5 ml/kg followed by infusion at a rate of 0.25 ml/kg/min to a total dose of 1000 ml. At the 16th hour consciousness was restored to GCS-15. In severe FTO intoxications ILE can be used as an additional method of controlling cardiotoxic and neurotoxic effects.","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"688 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132618737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Marinov, Dobri Ivanov, S. Zlateva, S. Dimitrova, G. Kehayova, M. Radeva
The use of intravenous lipid emulsions (ILEs) is a relatively new method of treatment in toxicology. Initially, it was applied to control the resistant to other therapeutic methods systemic toxicity of local anesthetics. In the last decade this therapeutic method has been approved and recommended. Thereafter, attempts have been made to clarify the effect of ILEs in cases of acute intoxications with lipophilic xenobiotics, other than the local anesthetics.
{"title":"Intravenous lipid infusion in toxicological practice","authors":"P. Marinov, Dobri Ivanov, S. Zlateva, S. Dimitrova, G. Kehayova, M. Radeva","doi":"10.14748/SSP.V1I1.5047","DOIUrl":"https://doi.org/10.14748/SSP.V1I1.5047","url":null,"abstract":"The use of intravenous lipid emulsions (ILEs) is a relatively new method of treatment in toxicology. Initially, it was applied to control the resistant to other therapeutic methods systemic toxicity of local anesthetics. In the last decade this therapeutic method has been approved and recommended. Thereafter, attempts have been made to clarify the effect of ILEs in cases of acute intoxications with lipophilic xenobiotics, other than the local anesthetics.","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"2009 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121010472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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