Pub Date : 2018-06-21DOI: 10.15406/mojddt.2018.02.00042
K. S
{"title":"Sustained drug delivery of capecitabine using natural (bee wax) and synthetic polymer (PLGA)","authors":"K. S","doi":"10.15406/mojddt.2018.02.00042","DOIUrl":"https://doi.org/10.15406/mojddt.2018.02.00042","url":null,"abstract":"","PeriodicalId":18704,"journal":{"name":"MOJ Drug Design Development & Therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89895869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-18DOI: 10.15406/mojddt.2018.02.00041
B. Sakshi, Wakode Sharad
Plant‒based products have been known as both nourishment and medicines since ancient times. From the very beginning of the civilization, there is an outrageous relationship between people and plants. In antiquated period the arrangement of treatment was not enhanced like today. The antiquated individuals used to use several parts of plants in various treatment purposes. Plants were not only utilized as medicine, but also in a number of their daily jobs (e.g., fishing, hunting, etc.) purposes. Eventually, plants are the ultimate care taker of environment in a sense. Since acetylsalicylic acid, a synthetic derivative of salicin produced from willow bark, was first presented in 1897,1 natural products have become major sources for chemical compounds used as starting materials. A solitary part of plant may comprise of various therapeutic esteems, but it has been proved that direct intake of crude plant is not good, as it contains both essential and nonessential components. The nonessential ones may not be required by the body in mending purposes or in other circumstances; the nonessential components may in actuality be toxic to the body under some cases. Even the intake of the essential components via the crude extract may lead to an improper dose.2 Within current days considerable research has been progressed in the exploitation of therapeutic plants, all the rage the therapy of various stress‒related disorders caused beside metabolism of oxygen leads to the generation of free radical.3 Free radicals cause weariness of immune system antioxidants, change in gene expression and induce abnormal proteins and add to in excess of one hundred issue in individuals including arthritis, atherosclerosis, ischemia and reperfusion injury of many tissues, central nervous system injury, diabetes, gastritis, cancer and AIDS. Oxidative stress may have critical impact in the glucose transport protein (GLUT) or at insulin receptor.4 The correct part of oxidative stress in the etiology of human diabetes is however not known. Longstanding diabetes is related with modifications in mitochondrial metabolism that outcome in both expanded arrangement of reactive oxygen species (ROS) and disappointment of bioenergetics. Specifically, diabetes causes dysfunction of mitochondria in those tissues very subject to aerobic metabolism, for example, heart, cerebrum and skeletal muscle. The level of mitochondrial failure has been corresponded with the term of diabetes.5 Scroungers of oxidative stress may have an impact in lessening the expanded serum glucose level in diabetes and may mitigate diabetes and in addition diminish its auxiliary entanglements.6 Scroungers of oxidative stress possibly will undergo an impact in reducting the raised serum glucose level in diabetes and in addition diminish its supporting entanglements. Inflammation is normal reaction of the mammalian body to an assortment of hostile specialists including parasites, pathogenic microorganism, poisonous concoction
{"title":"Comparative in–vitro antioxidant, anti–inflammatory and anti diabetic activity of standardized polar extracts of S alata","authors":"B. Sakshi, Wakode Sharad","doi":"10.15406/mojddt.2018.02.00041","DOIUrl":"https://doi.org/10.15406/mojddt.2018.02.00041","url":null,"abstract":"Plant‒based products have been known as both nourishment and medicines since ancient times. From the very beginning of the civilization, there is an outrageous relationship between people and plants. In antiquated period the arrangement of treatment was not enhanced like today. The antiquated individuals used to use several parts of plants in various treatment purposes. Plants were not only utilized as medicine, but also in a number of their daily jobs (e.g., fishing, hunting, etc.) purposes. Eventually, plants are the ultimate care taker of environment in a sense. Since acetylsalicylic acid, a synthetic derivative of salicin produced from willow bark, was first presented in 1897,1 natural products have become major sources for chemical compounds used as starting materials. A solitary part of plant may comprise of various therapeutic esteems, but it has been proved that direct intake of crude plant is not good, as it contains both essential and nonessential components. The nonessential ones may not be required by the body in mending purposes or in other circumstances; the nonessential components may in actuality be toxic to the body under some cases. Even the intake of the essential components via the crude extract may lead to an improper dose.2 Within current days considerable research has been progressed in the exploitation of therapeutic plants, all the rage the therapy of various stress‒related disorders caused beside metabolism of oxygen leads to the generation of free radical.3 Free radicals cause weariness of immune system antioxidants, change in gene expression and induce abnormal proteins and add to in excess of one hundred issue in individuals including arthritis, atherosclerosis, ischemia and reperfusion injury of many tissues, central nervous system injury, diabetes, gastritis, cancer and AIDS. Oxidative stress may have critical impact in the glucose transport protein (GLUT) or at insulin receptor.4 The correct part of oxidative stress in the etiology of human diabetes is however not known. Longstanding diabetes is related with modifications in mitochondrial metabolism that outcome in both expanded arrangement of reactive oxygen species (ROS) and disappointment of bioenergetics. Specifically, diabetes causes dysfunction of mitochondria in those tissues very subject to aerobic metabolism, for example, heart, cerebrum and skeletal muscle. The level of mitochondrial failure has been corresponded with the term of diabetes.5 Scroungers of oxidative stress may have an impact in lessening the expanded serum glucose level in diabetes and may mitigate diabetes and in addition diminish its auxiliary entanglements.6 Scroungers of oxidative stress possibly will undergo an impact in reducting the raised serum glucose level in diabetes and in addition diminish its supporting entanglements. Inflammation is normal reaction of the mammalian body to an assortment of hostile specialists including parasites, pathogenic microorganism, poisonous concoction","PeriodicalId":18704,"journal":{"name":"MOJ Drug Design Development & Therapy","volume":"148 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74730075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-13DOI: 10.15406/mojddt.2018.02.00040
N. Christensen
We found some years ago an unknow non‒coding RNA fragment in mononuclear cells designated Heg lnc RNA (European Nucleotide Archive: EU137727.1).1,2 Heg RNA was located to chromosome 1, antisense to and overlaps a larger part of exon 7 from Nucks mRNA. Nucks (nuclear ubiquitous casein kinase and cyclin‒dependent substrate) plays a major role in the regulation of transcription and is a substrate for Cdk1. Heg and other RNA products were quantified by RT‒PCR‒HPLC.1 The mean concentration of Heg lnc RNA in normal subjects were 0.15±0.01 amol/μg of DNA.2 Surprisingly we found that Heg lnc RNA was close and negatively correlated with concentrations of TSH receptor autoantibodies (TRAb) in patients with untreated Graves disease. We also study Cdk1 and CK2 mRNAs (homo sapiens casein kinase I and II), which both are members of the cyclin‒ dependent kinase cascade. Cdk1 is important for cell division and differentiation.3 Cdk1 was positively correlated with concentrations of TRAb, but only provided Heg was included in the analysis. We did not find other RNA fragments, which correlated with TRAb. The interaction between Heg lnc RNA and Cdk1 mRNA explained a large and high significant part of the variation in TRAb. It is easy to understand why Cdk1, which regulates cell cycle, correlates with TRAb. The mechanism of action for Heg, on the other hand, is not known. Heg may reflect effects of Nucks, but there was no correlation between Nucks and TRAb. Gene expression in mononuclear cells after incubation for 20 hours led to the expected increase in GCR and NF‒kB mRNAs, whereas Heg, Nucks mRNA and Cd14 mRNA were only slightly changed. A general inhibition of gene expression reduced the concentration of both Nucks mRNA and Heg significant.
{"title":"Heg lnc RNA and Cdk1 mRNA in mononuclear cells and regulation of autoantibody levels","authors":"N. Christensen","doi":"10.15406/mojddt.2018.02.00040","DOIUrl":"https://doi.org/10.15406/mojddt.2018.02.00040","url":null,"abstract":"We found some years ago an unknow non‒coding RNA fragment in mononuclear cells designated Heg lnc RNA (European Nucleotide Archive: EU137727.1).1,2 Heg RNA was located to chromosome 1, antisense to and overlaps a larger part of exon 7 from Nucks mRNA. Nucks (nuclear ubiquitous casein kinase and cyclin‒dependent substrate) plays a major role in the regulation of transcription and is a substrate for Cdk1. Heg and other RNA products were quantified by RT‒PCR‒HPLC.1 The mean concentration of Heg lnc RNA in normal subjects were 0.15±0.01 amol/μg of DNA.2 Surprisingly we found that Heg lnc RNA was close and negatively correlated with concentrations of TSH receptor autoantibodies (TRAb) in patients with untreated Graves disease. We also study Cdk1 and CK2 mRNAs (homo sapiens casein kinase I and II), which both are members of the cyclin‒ dependent kinase cascade. Cdk1 is important for cell division and differentiation.3 Cdk1 was positively correlated with concentrations of TRAb, but only provided Heg was included in the analysis. We did not find other RNA fragments, which correlated with TRAb. The interaction between Heg lnc RNA and Cdk1 mRNA explained a large and high significant part of the variation in TRAb. It is easy to understand why Cdk1, which regulates cell cycle, correlates with TRAb. The mechanism of action for Heg, on the other hand, is not known. Heg may reflect effects of Nucks, but there was no correlation between Nucks and TRAb. Gene expression in mononuclear cells after incubation for 20 hours led to the expected increase in GCR and NF‒kB mRNAs, whereas Heg, Nucks mRNA and Cd14 mRNA were only slightly changed. A general inhibition of gene expression reduced the concentration of both Nucks mRNA and Heg significant.","PeriodicalId":18704,"journal":{"name":"MOJ Drug Design Development & Therapy","volume":"241 0 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74906104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-12DOI: 10.15406/MOJDDT.2018.02.00039
N. Dhingra, Akanksha, V. Mehta, Richa Dhingra, Monika
Steroids assume an essential part in a several processes, ranging from the differentiation, growth, development, physiological and regenerative functions in the human body,1 because of their ability to cross membrane easily.2 Steroids as well as their derivatives have the potential to be developed as drugs for the treatment of a large number of diseases including cardiovascular, autoimmune diseases, brain tumours, breast cancer, osteoarthritis, prostate cancer etc.3‒6 The promise of using steroids for development of lead molecules lies in the regulation of a variety of biological processes by these molecules and being a fundamental class of signalling molecules.7,8 Benign prostatic hyperplasia (BPH) and Prostate Cancer (PC), are the leading disorders of the old age men. These prostatic diseases are characterized by a progressive enlargement of prostatic tissue, that results in the obstruction of proximal urethra and cause urinary flow disturbances.9 Nearly half of men aged over 50years show histological evidence of BPH and PC and proportion increases to 80% by the age of 70.10 Dihyrotestesterone (DHT) hypothesis postulates that androgens play an important role in growth of prostate. Male hormone testosterone (T), is biosynthesized in testicles and adrenal glands, and converted to more potent androgen i.e. dihydrotestosterone (DHT) by NADPH dependent enzyme 5α‒Reductase (5AR). 5AR is a membrane‒ bound enzyme that irreversibly catalyses the reduction of 4‒ene‒3‒ oxosteroids to the corresponding 5α‒3‒oxosteroids Figure 1. Three isozymes have been identified for 5AR based on their gene sequence, location, and pH. Type 1 isozyme (5AR1) is expressed in skin and liver and show maximal activity at pH ranging from 6.0∼8.5, whereas type 2 isozyme (5AR2) shows its activity at pH 5.5 in prostate and other genital tissues.11 Recently, type 3 isozyme (5AR3) has also been identified in castration‒resistant prostate cancer cells including other tissues like pancreas, brain, skin and adipose tissues.12‒14 5AR has emerged as a therapeutic target, as 5α‒Reductase Inhibitors (5ARIs) by causing the suppression of DHT biosynthesis provided a logical treatment for BPH and PC.15,16 Further, isolation and characterisation of the three different isozymes have led in the advancement of new and selective inhibitors with improved anticancer therapies.17 Computer Aided Drug Designing (CADD) in perspective of QSAR between natural activity and physicochemical descriptor, is a gadget that has been utilized to build the productivity of the medication disclosure process.18 Though primary sequence of 5AR isozymes, are available, but crystal structure of 5AR have yet not been determined as yet they have not been isolated and purified from tissues or cells despite. In the absence of structural information of target protein, different receptor mapping techniques can create permitting developing 3D surrogate of the coupling pocket and could be utilized to predict
{"title":"In silico Identification of potential 5α‒reductase inhibitors for prostatic diseases: QSAR modelling, molecular docking, and pre ADME predictions","authors":"N. Dhingra, Akanksha, V. Mehta, Richa Dhingra, Monika","doi":"10.15406/MOJDDT.2018.02.00039","DOIUrl":"https://doi.org/10.15406/MOJDDT.2018.02.00039","url":null,"abstract":"Steroids assume an essential part in a several processes, ranging from the differentiation, growth, development, physiological and regenerative functions in the human body,1 because of their ability to cross membrane easily.2 Steroids as well as their derivatives have the potential to be developed as drugs for the treatment of a large number of diseases including cardiovascular, autoimmune diseases, brain tumours, breast cancer, osteoarthritis, prostate cancer etc.3‒6 The promise of using steroids for development of lead molecules lies in the regulation of a variety of biological processes by these molecules and being a fundamental class of signalling molecules.7,8 Benign prostatic hyperplasia (BPH) and Prostate Cancer (PC), are the leading disorders of the old age men. These prostatic diseases are characterized by a progressive enlargement of prostatic tissue, that results in the obstruction of proximal urethra and cause urinary flow disturbances.9 Nearly half of men aged over 50years show histological evidence of BPH and PC and proportion increases to 80% by the age of 70.10 Dihyrotestesterone (DHT) hypothesis postulates that androgens play an important role in growth of prostate. Male hormone testosterone (T), is biosynthesized in testicles and adrenal glands, and converted to more potent androgen i.e. dihydrotestosterone (DHT) by NADPH dependent enzyme 5α‒Reductase (5AR). 5AR is a membrane‒ bound enzyme that irreversibly catalyses the reduction of 4‒ene‒3‒ oxosteroids to the corresponding 5α‒3‒oxosteroids Figure 1. Three isozymes have been identified for 5AR based on their gene sequence, location, and pH. Type 1 isozyme (5AR1) is expressed in skin and liver and show maximal activity at pH ranging from 6.0∼8.5, whereas type 2 isozyme (5AR2) shows its activity at pH 5.5 in prostate and other genital tissues.11 Recently, type 3 isozyme (5AR3) has also been identified in castration‒resistant prostate cancer cells including other tissues like pancreas, brain, skin and adipose tissues.12‒14 5AR has emerged as a therapeutic target, as 5α‒Reductase Inhibitors (5ARIs) by causing the suppression of DHT biosynthesis provided a logical treatment for BPH and PC.15,16 Further, isolation and characterisation of the three different isozymes have led in the advancement of new and selective inhibitors with improved anticancer therapies.17 Computer Aided Drug Designing (CADD) in perspective of QSAR between natural activity and physicochemical descriptor, is a gadget that has been utilized to build the productivity of the medication disclosure process.18 Though primary sequence of 5AR isozymes, are available, but crystal structure of 5AR have yet not been determined as yet they have not been isolated and purified from tissues or cells despite. In the absence of structural information of target protein, different receptor mapping techniques can create permitting developing 3D surrogate of the coupling pocket and could be utilized to predict","PeriodicalId":18704,"journal":{"name":"MOJ Drug Design Development & Therapy","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84310734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-08DOI: 10.15406/MOJDDT.2018.02.00038
Claudia M. Plaza, Celina Pérez de Salazar, Ramon E Plaza, M. Vizcaya, Gabriela Rodríguez-Castillo, Gerardo Medina-Ramírez
Infectious diseases caused by bacteria, fungi and others microorganism remain a major threat to public health, despite tremendous progress in human medicine. Their impact is particularly great in developing countries because of the relative unavailability of medicines and the emergence of widespread drug resistance. Interests in natural products with antimicrobial properties have evolved as a result of current problems associated with the use of antibiotics. Plant derived antimicrobial compounds have been the source of novel therapeutics for many years. This may be due to the fact that these compounds show the structural intricacy and chemical diversity required to interact with antibacterial protein targets and provide vast opportunities for new drug development.1,2 Just as the higher plants have been used in folk medicine, lichens have also been used in food and in folk medicine in many countries over a considerable period of time. A lichen is a composite organism that emerges from algae or cyanobacteria (or both) living among filaments of fungus in a mutually beneficial (symbiotic) relationship. They represent taxonomically and physiologically a diverse group of organisms. Lichens produce a number of characteristic secondary metabolites called lichen substances, which seldom occur in other organisms. Depsides and depsidones are among the most common secondary metabolites produced by the fungal symbiont. The lichens and their metabolites are shown to possess various biological activities such as antimicrobial, antiviral, antiprotozoal, enzyme inhibitory, insecticidal, antitermite, cytotoxic, antioxidant, antiherbivore, wound healing, analgesic and anti‒inflammatory.1‒5 Lichens are very abundant organisms and can withstand hostile environmental conditions; therefore, they are able to colonize diverse ecosystems. It is estimated that there are between 17.500 and 20.000 species of lichens known in the world, with about 1.500 lichen‒shaped fungi.6 In Venezuela, there are 1.320 species reported by and probably around an estimated 4.000 are expected to be discovered of which 85% are concentrated in the Venezuelan Andes, which represents one of the most rich and diverse regions of the world. Thus the aim of the present study was investigate the antibacterial and antifungal potential of four lichens from Venezuelan Andes i.e., Everniastrum cf. vexans, Parmotrema blanquetianun, Parmotrema reticulatum, Peltigera laciniata.7‒9
{"title":"In vitro analysis of antibacterial and antifungal potential of lichen species of Everniastrum cf vexans, Parmotrema blanquetianum, Parmotrema reticulatum and Peltigera laciniata","authors":"Claudia M. Plaza, Celina Pérez de Salazar, Ramon E Plaza, M. Vizcaya, Gabriela Rodríguez-Castillo, Gerardo Medina-Ramírez","doi":"10.15406/MOJDDT.2018.02.00038","DOIUrl":"https://doi.org/10.15406/MOJDDT.2018.02.00038","url":null,"abstract":"Infectious diseases caused by bacteria, fungi and others microorganism remain a major threat to public health, despite tremendous progress in human medicine. Their impact is particularly great in developing countries because of the relative unavailability of medicines and the emergence of widespread drug resistance. Interests in natural products with antimicrobial properties have evolved as a result of current problems associated with the use of antibiotics. Plant derived antimicrobial compounds have been the source of novel therapeutics for many years. This may be due to the fact that these compounds show the structural intricacy and chemical diversity required to interact with antibacterial protein targets and provide vast opportunities for new drug development.1,2 Just as the higher plants have been used in folk medicine, lichens have also been used in food and in folk medicine in many countries over a considerable period of time. A lichen is a composite organism that emerges from algae or cyanobacteria (or both) living among filaments of fungus in a mutually beneficial (symbiotic) relationship. They represent taxonomically and physiologically a diverse group of organisms. Lichens produce a number of characteristic secondary metabolites called lichen substances, which seldom occur in other organisms. Depsides and depsidones are among the most common secondary metabolites produced by the fungal symbiont. The lichens and their metabolites are shown to possess various biological activities such as antimicrobial, antiviral, antiprotozoal, enzyme inhibitory, insecticidal, antitermite, cytotoxic, antioxidant, antiherbivore, wound healing, analgesic and anti‒inflammatory.1‒5 Lichens are very abundant organisms and can withstand hostile environmental conditions; therefore, they are able to colonize diverse ecosystems. It is estimated that there are between 17.500 and 20.000 species of lichens known in the world, with about 1.500 lichen‒shaped fungi.6 In Venezuela, there are 1.320 species reported by and probably around an estimated 4.000 are expected to be discovered of which 85% are concentrated in the Venezuelan Andes, which represents one of the most rich and diverse regions of the world. Thus the aim of the present study was investigate the antibacterial and antifungal potential of four lichens from Venezuelan Andes i.e., Everniastrum cf. vexans, Parmotrema blanquetianun, Parmotrema reticulatum, Peltigera laciniata.7‒9","PeriodicalId":18704,"journal":{"name":"MOJ Drug Design Development & Therapy","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85277940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-01DOI: 10.15406/MOJDDT.2018.02.00037
A. Kushwah, K. Saini, G. Gupta
Trigonella foenum graecum TF belongs to the family Fabaceae it has been from ancient time used as a spice and traditionally ethno pharmacological medicine for promoting digestion and reduce blood sugar levels in a diabetic patient in India In the present study soluble dietary fiber SDF was isolated from TF seeds and investigates the role of SDF of TF against olanzapine induced metabolic complications Metabolic syndrome was induced by oral administration of OLZ mg kg in rats for days Then rats were treated with OLZ and SDFF of TF at and mg kg po day and metformin as a standard mg kg po day SDF of TF treatment significantly decreased body weight gain feed and water intake blood glucose oral glucose tolerance test OGTT lipid profile liver enzymes uric acid and improved hemodynamic parameters antioxidant status and reduced histopathological changes caused by OLZ treatment in rats SDF of TF increased the satiety suppresses appetite and improved the glucose and lipid metabolism and antioxidant potential exert the beneficial role in olanzapine induced metabolic syndrome
{"title":"Soluble dietary fiber fraction of Trigonella foenum graecum seeds prevent olanzapine induced metabolic syndrome in rats","authors":"A. Kushwah, K. Saini, G. Gupta","doi":"10.15406/MOJDDT.2018.02.00037","DOIUrl":"https://doi.org/10.15406/MOJDDT.2018.02.00037","url":null,"abstract":"Trigonella foenum graecum TF belongs to the family Fabaceae it has been from ancient time used as a spice and traditionally ethno pharmacological medicine for promoting digestion and reduce blood sugar levels in a diabetic patient in India In the present study soluble dietary fiber SDF was isolated from TF seeds and investigates the role of SDF of TF against olanzapine induced metabolic complications Metabolic syndrome was induced by oral administration of OLZ mg kg in rats for days Then rats were treated with OLZ and SDFF of TF at and mg kg po day and metformin as a standard mg kg po day SDF of TF treatment significantly decreased body weight gain feed and water intake blood glucose oral glucose tolerance test OGTT lipid profile liver enzymes uric acid and improved hemodynamic parameters antioxidant status and reduced histopathological changes caused by OLZ treatment in rats SDF of TF increased the satiety suppresses appetite and improved the glucose and lipid metabolism and antioxidant potential exert the beneficial role in olanzapine induced metabolic syndrome","PeriodicalId":18704,"journal":{"name":"MOJ Drug Design Development & Therapy","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80474247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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