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DFT and Molecular docking study of natural molecules proposed for COVID-19 treatment 用于新冠肺炎治疗的天然分子的DFT和分子对接研究
IF 1.1 Q3 Chemistry Pub Date : 2021-03-04 DOI: 10.48317/IMIST.PRSM/MORJCHEM-V9I2.21931
H. E. Hadki
Abstract Emergence and spread of corona virus disease 2019 (COVID-19), caused by severe respiratory syndrome coronavirus, is considered a public health emergency threatening global health systems, as of June, 2020, It caused a cumulative total of 9,033,423 confirmed cases and more than 469,539 deaths across 215 countries, person to-person transmission has being identified as the route for spreading. So far, the lack of effective vaccines for the treatment or prevention of Covid-19 has further worsened the situation. In this context, the present study aims to assess whether naturally occurring components have an antiviral effect via a computational modeling approach. Density Functional theory (DFT) was performed to estimate the kinetic parameters, frontier molecular orbitals, molecular electrostatic potential as well as chemical reactivity descriptors of various ligands. The results revealed that Crocin and Digitoxigenin exhibited a potential applicant with the lowest resistance to electronic charge transfer with a chemical hardness of 2.19eV and 2.96eV respectively, as well as the lowest HOMO-LUMO difference. In addition to the DFT calculation, a docking simulation study was conducted on the SARS-CoV-2 base protease (PDB: 6LU7) to determine the binding affinity of ligands. The findings show that Crocin exhibits the lowest binding energy of -8.1 Kcal/mol and may be a good inhibitor of CoV-2-SARS compared to hydroxychloroquine and chloroquine, which have a binding affinity of -5.4 and -4.9 Kcal/mol, respectively. The high binding affinity of L3 was assigned to the existence of 14 hydrogen bonds connecting the ligand to the critical amino acid residues of the receptor.
摘要由严重呼吸综合征冠状病毒引起的2019冠状病毒病(新冠肺炎)的出现和传播被认为是威胁全球卫生系统的突发公共卫生事件,截至2020年6月,它在215个国家累计造成9033423例确诊病例和469539多人死亡,人与人之间的传播已被确定为传播途径。到目前为止,缺乏治疗或预防新冠肺炎的有效疫苗使情况进一步恶化。在这种情况下,本研究旨在通过计算建模方法评估天然成分是否具有抗病毒作用。利用密度泛函理论(DFT)估算了各种配体的动力学参数、前沿分子轨道、分子静电势以及化学反应描述符。结果表明,Crocin和Digitoxigenin表现出对电子电荷转移具有最低电阻的潜在申请人,化学硬度分别为2.19eV和2.96eV,HOMO-LUMO差异最小。除了DFT计算外,还对严重急性呼吸系统综合征冠状病毒2型碱性蛋白酶(PDB:6LU7)进行了对接模拟研究,以确定配体的结合亲和力。研究结果表明,与羟氯喹和氯喹相比,Crocin的结合能最低,为-8.1Kcal/mol,可能是CoV-2-ARS的良好抑制剂,羟氯喹的结合亲和力分别为-5.4和-4.9kcal/mol。L3的高结合亲和力归因于存在将配体连接到受体的关键氨基酸残基的14个氢键。
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引用次数: 0
Characterization of the reverse osmosis membrane fouled by Oum Errabia river water of Khenifra city, Morocco 摩洛哥Khenifra市Oum Errabia河水污染反渗透膜的特性研究
IF 1.1 Q3 Chemistry Pub Date : 2021-02-18 DOI: 10.48317/IMIST.PRSM/MORJCHEM-V9I1.25140
M. Ennouhi, S. E. Aggadi, L. Hasnaoui, M. Azzouzi, A. Hourch
The Khenifra desalination plant is designed to produce 36,290 m 3 /d of drinking water by 2030. Since the start-up of this plant in 2013, several problems have been encountered in the reverse osmosis unit due to membrane fouling. Clogging is a major issue related to the interaction between feed water quality and the pre-treatment process. Membrane autopsy, monitoring of seasonal variations in raw water and surveillance of operating parameters are carried out. The results obtained show that feed water is subject to large seasonal variations in terms of temperature (10 - 25 °C), conductivity (1395 - 2500 µS.cm -1 ) and Silt Density Index (SDI) (< 3) in 2017 using microfiltration, which influences the fouling of the membrane. Membrane autopsy by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS) and X-ray Diffraction (XRD), shows the formation of large cracks on the surface of the membrane and that the fouling layer is mainly composed of: CaCO 3 (38.70 %), Al 2 O 3 (17.42 %), Ba(SO 4 ) 2 (15.23 %), MgCl 2 (15.02 %) and SiO 2 (13.64%).
Khenifra海水淡化厂的设计目标是到2030年每天生产36290立方米的饮用水。自2013年该装置启动以来,由于膜污染,反渗透装置遇到了几个问题。堵塞是与给水质量和预处理过程之间的相互作用有关的一个主要问题。进行了薄膜尸检、原水季节变化监测和操作参数监测。结果表明,2017年,使用微滤技术,进水在温度(10-25°C)、电导率(1395-2500µS.cm-1)和淤泥密度指数(SDI)(<3)方面存在较大的季节性变化,这会影响膜的结垢。通过扫描电子显微镜(SEM)、能谱仪(EDS)和X射线衍射仪(XRD)对膜进行解剖,发现膜表面形成了较大的裂纹,污垢层主要由CaCO3(38.70%)、Al2O3(17.42%)、Ba(SO4)2(15.23%)、MgCl2(15.02%)和SiO2(13.64%)组成。
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引用次数: 1
Assessment of soil trace metal contamination of an uncontrolled landfill and its vicinity: the case of the city of ‘Targuist’ (Northern Morocco) 对不受控制的垃圾填埋场及其附近地区土壤微量金属污染的评估:以“Targuist”市为例(摩洛哥北部)
IF 1.1 Q3 Chemistry Pub Date : 2021-02-16 DOI: 10.48317/IMIST.PRSM/MORJCHEM-V9I2.23680
Kaouthar Andaloussi, H. Achtak, C. Nakhcha, K. Haboubi, M. Stitou
This study aims to assess, for the first time, soil Trace Metal Elements (TME) contamination level in an uncontrolled landfill and its vicinity of 'Targuist' (town in northern Morocco). Soil samples were collected at two depths (20 and 40cm) from 16 sampling sites. Samples were characterized for their physicochemical parameters (pH, electrical conductivity (EC), organic matter (OM) and total organic carbon (TOC)) and for their TME (copper (Cu), zinc (Zn), cadmium (Cd) and chromium (Cr)) using atomic absorption spectroscopy (ASS). The results show no significant differences between soils sampled at 20cm or 40cm depths regarding the tested parameters. While significant differences between sampling sites In landfill and Out landfill is observed particularly regarding pH, CaCO3, TOC, and Cd. Overall, our results show that soil physicochemical properties follow a spatial variability with decreasing values moving away from the landfill. Regarding TME soil contents, our results show contamination levels in most of the sampling sites of the study area. Furthermore, the total TME concentrations in soils vary according to the type of the studied metal and to the sampling site. Zn, Cu and Cd show significant positive correlations with pH. However, Cd has no correlation with any other trace elements or soil physicochemical properties. Meanwhile, Cr shows a significant negative correlation with Zn and Cu. OM, TOC, CaCO3 and EC are strongly and positively correlated. These results are well illustrated in the outcomes of the Principal Components Analysis and Hierarchical Cluster Analysis.
这项研究的目的是首次评估一个未受控制的垃圾填埋场及其“Targuist”(摩洛哥北部城镇)附近的土壤微量金属元素(TME)污染水平。在16个采样点的20和40cm两个深度采集土壤样品。利用原子吸收光谱(ASS)对样品的理化参数(pH、电导率(EC)、有机质(OM)和总有机碳(TOC))和TME(铜(Cu)、锌(Zn)、镉(Cd)和铬(Cr))进行了表征。结果表明,在20cm和40cm深度取样的土壤在测试参数方面没有显著差异。虽然在填埋区和填埋区以外的采样点之间存在显著差异,特别是在pH、CaCO3、TOC和Cd方面。总体而言,我们的结果表明,土壤物理化学性质遵循空间变异性,随着远离填埋区,数值逐渐减小。在TME土壤含量方面,我们的结果显示了研究区大多数采样点的污染水平。此外,土壤中TME的总浓度根据所研究金属的类型和采样地点而变化。Zn、Cu和Cd与ph呈显著正相关,而Cd与其他微量元素及土壤理化性质均无相关性。Cr与Zn、Cu呈显著负相关。OM、TOC、CaCO3和EC呈显著正相关。这些结果在主成分分析和层次聚类分析的结果中得到了很好的说明。
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引用次数: 2
In silico Studies of some potential anti-cancer agents on M19-MEL cell line 一些潜在抗癌药物在M19-MEL细胞系上的硅片研究
IF 1.1 Q3 Chemistry Pub Date : 2021-02-14 DOI: 10.48317/IMIST.PRSM/MORJCHEM-V9I2.20575
A. B. Umar
The resistance of melanoma cancer cells to the known treatments has become a barrier to the success of chemotherapy.  In this research, a quantitative evaluation of the structure-activity relationship (QSAR) was carried out on 57 anti-cancer compounds and some selected potent compounds were screened through Lipinski’s rule and docked. Genetic function algorithm (GFA) was adopted in variables selection and Multiple linear regression (MLR) was used to generate the model. The built QSAR model showed good statistical parameters (( (0.904), (0.885), Q 2 cv (0.873) and (0.779)). The cR⁠ 2 ⁠ P for Y-randomization is 0.749 and the applicability domain was also determined. The predictive ability of the model was found to be satisfactory and could be used to predict the anti-cancer activity of compounds on M19 MEL cell line. 4 most potent compounds were selected among the data set and screened through Lipinski's rule of five filters for oral bioavailability, ADMET risk filter for a drug like features. Later, V600E-BRAF, a known melanoma cancer target was used for docking. Based on the interaction energy and types of interactions involved, the selected compounds were identified as the best hits against V600E-BRAF. This research would help in the lead identification and design of novel drugs.
黑色素瘤癌细胞对已知治疗方法的耐药性已经成为化疗成功的障碍。本研究对57种抗癌化合物的构效关系(QSAR)进行了定量评价,并通过Lipinski规则筛选筛选出部分有效化合物并进行了对接。变量选择采用遗传函数算法(GFA),模型生成采用多元线性回归(MLR)。建立的QSAR模型具有良好的统计参数((0.904),(0.885),q2 cv(0.873)和(0.779))。y随机化的cR (2) P为0.749,并确定了该方法的适用范围。该模型的预测能力令人满意,可用于预测化合物对M19 MEL细胞株的抗癌活性。从数据集中选择了4种最有效的化合物,并通过Lipinski的口服生物利用度五过滤器规则进行筛选,ADMET风险过滤器用于药物特征。随后,利用已知的黑色素瘤肿瘤靶点V600E-BRAF进行对接。根据所涉及的相互作用能和相互作用类型,确定了所选化合物对V600E-BRAF的最佳打击。这项研究将有助于新药物的先导鉴定和设计。
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引用次数: 2
Simultaneous Electrochemical Determination of Dihydroxybenzene Isomers at 1-Butyl-3-Methylimidazolium Hexafluorophosphate Modified Pencil Graphite Electrode 在1-丁基-3-甲基咪唑六氟磷酸修饰铅笔石墨电极上同时电化学测定二羟基苯异构体
IF 1.1 Q3 Chemistry Pub Date : 2021-02-14 DOI: 10.48317/IMIST.PRSM/MORJCHEM-V9I2.19188
N. T. Tonu
A simplistic and inexpensive electrochemical platform has been fabricated for the simultaneous detection of Dihydroxybenzene Isomers (DHBIs); named- Hydroquinone (HQ), Catechol (CC) and Resorcinol (RS); in aqueous system. Cyclic Voltammetry (CV) and Differential Pulse Voltammetry (DPV) were adopted for the detection technique. 2B pencil (Faber Castell) collected from the resident stationary shop was used for fabricating Pencil Graphite Electrode (PGE) used as working electrode. PGE was characterized by SEM and EDX. It was modified electrochemically by ionic liquid, 1-Butyl-3-Methylimidazolium hexafluorophosphate (BIHP). Total analyses were performed in phosphate buffer solution (PBS) at pH 7.0. BIHP-PGE showed good selectivity and robust anti-interference for detection of HQ, CC and RS simultaneously in aqueous media. For HQ, CC and RS, the limit of detection is 9.09 μML -1 , 8.15 μM L -1 and 26.78 μM L -1 respectively and sensitivity is 525.21 μA/mM/cm 2 , 585.68 μA/mM/cm 2 and 178.00 μA/mM/cm 2 respectively at BIHP-PGE in simultaneous detection.
制备了一个简单廉价的电化学平台,用于同时检测二羟基苯异构体(DHBI);命名为-氢醌(HQ)、邻苯二酚(CC)和间苯二酚(RS);在水系统中。检测方法采用循环伏安法(CV)和微分脉冲伏安法(DPV)。2B铅笔(Faber Castell)从居民固定商店收集,用于制造用作工作电极的铅笔石墨电极(PGE)。用扫描电镜和能谱仪对PGE进行了表征。用离子液体1-丁基-3-甲基咪唑鎓六氟磷酸盐(BIHP)对其进行电化学改性。在pH 7.0的磷酸盐缓冲溶液(PBS)中进行总分析。BIHP-PGE对水介质中HQ、CC和RS的同时检测具有良好的选择性和较强的抗干扰能力。对于HQ、CC和RS,BIHP-PGE同时检测的检出限分别为9.09μML-1、8.15μML-1和26.78μML-1,灵敏度分别为525.21μA/mM/cm2、585.68μA/mM/cm2和178.00μA/mM/cm2。
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引用次数: 0
Utilization of Olive Mill Waste in Microbial Electrolysis Cell 橄榄磨废料在微生物电解槽中的利用
IF 1.1 Q3 Chemistry Pub Date : 2021-02-14 DOI: 10.48317/IMIST.PRSM/MORJCHEM-V9I1.20653
H. Yemendzhiev, R. Koleva, F. Zerrouq, V. Nenov
Olive oil production is a source of huge amount of residuals knowns as OMW (Olive Mill Waste). The sustainable management and treatment of this waste is challenging due to presence of high amount of specific pollutants. The OMW is characterized by very high COD to BOD ratio with considerable content of polyphenols reaching up to 15g/l. Due to this, the biological utilization of OMW could be hindered or very slow when the conventional aerobic and anaerobic methods are used. In this study, the Microbial Electrolysis Cell (MEC) technology was applied as an alternative treatment approach. The method offers COD reduction and energy recovering in the form of hydrogen. The results demonstrated up to 65% efficiency in terms of COD and polyphenols removal which suggest that MEC, could be considered as an initial treatment stage in OMW utilization.
橄榄油生产过程中会产生大量被称为OMW(橄榄磨坊废弃物)的残留物。由于存在大量特定污染物,这种废物的可持续管理和处理具有挑战性。其特点是COD / BOD比值很高,多酚类化合物含量较高,可达15g/l。因此,当采用传统的好氧和厌氧方法时,有机物的生物利用可能会受到阻碍或非常缓慢。本研究采用微生物电解电池(MEC)技术作为一种替代处理方法。该方法以氢的形式提供COD降低和能量回收。结果表明,在COD和多酚的去除方面,MEC的效率高达65%,这表明MEC可以被认为是OMW利用的初始处理阶段。
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引用次数: 1
Water reuse after removing a textile dye methyl orange using a recyclable hydrotalcite material 使用可回收的水滑石材料去除纺织染料甲基橙后的水再利用
IF 1.1 Q3 Chemistry Pub Date : 2021-02-14 DOI: 10.48317/IMIST.PRSM/MORJCHEM-V9I1.21114
E. Mourid, M. Lakraimi, L. Benaziz, M. Cherkaoui
Hydrotalcite type material based on zinc, aluminum and carbonates was synthesized by coprecipitation method and its derived calcined at 500°C (CHT) was used to remove the textile dye methyl orange (MO). This adsorbent has a great potential for removing pollutants from aqueous solutions without generating sludge. Adsorption was performed in batch experiments. A rapid process of retention confirmed by kinetics reflects a high affinity between CHT material and MO dye. The adsorption isotherms follow the Langmuir model (L type). The results of several techniques suggest the intercalation of the pollutant between the hydrotacite sheets reconstructed from mixed oxides with a gallery of 2.35 nm. The retention capacity reaches 2500 mg/g with a removal rate of 100% for an optimum mass ratio MO/CHT of 0.3. After the recycling studies the material CHT justify its recyclability and confirms its efficiency for eliminating such pollutant.
采用共沉淀法合成了基于锌、铝和碳酸盐的水滑石型材料,并将其衍生物在500℃(CHT)下煅烧,用于去除纺织染料甲基橙(MO)。这种吸附剂在去除水溶液中的污染物而不产生污泥方面具有很大的潜力。批量吸附实验。动力学证实了快速的保留过程,反映了CHT材料与MO染料之间的高亲和力。吸附等温线符合Langmuir模型(L型)。几种技术的结果表明,污染物在由混合氧化物重建的水滑石薄片之间嵌入了2.35 nm的通道。当MO/CHT质量比为0.3时,截留量可达2500 mg/g,去除率为100%。经过对材料的回收研究,证明了其可回收性,并证实了其消除此类污染物的效率。
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引用次数: 2
Nanofiltration and reverse osmosis membrane for nitrate removal: performance study and economic evaluation 纳滤和反渗透膜去除硝酸盐:性能研究和经济评价
IF 1.1 Q3 Chemistry Pub Date : 2021-02-14 DOI: 10.48317/IMIST.PRSM/MORJCHEM-V9I1.24357
J. Touir, S. El-ghzizel, H. Belhamidi, F. Elazhar, M. Taky, A. Elmidaoui
Contamination of water with nitrates is a global problem that poses a serious threat to human health. In Morocco, a country characterized by limited water resources, groundwater accounts for almost 32% of total resources. However, 6% of these water resources are estimated to have nitrate levels greater than 50 mg / L, the level recommended by the world health organization for drinking water (WHO) and in some areas of high agricultural activity the nitrate content exceeds 250 mg / L. In the first part of this study, the efficiency of two commercial membranes, Reverse Osmosis and Nanofiltration membranes (Dow-FilmTec) is experimentally compared and assessed for nitrate removal by using real brackish water, containing 850-1100 mg/l of total dissolved solids (TDS) and 119-130 mg/l of nitrate. To accomplish this goal, the influence of operating conditions (pressure, recovery rate) on nitrate removal is discussed. The salt rejection from each membranes and the energy consumption are also calculated to choose the best membrane for nitrate removal and drinking water production. The pilot used in this study (supplied by the French company TIA) is an industrial pilot plant having two modules equipped with various spiral commercial membranes with an area of  7.6 m².  The second part of this study estimates the total cost of the produced water by the application of the two studied membranes (NF and RO) for a plant of nitrate removal having a capacity of production of 2400 m 3 /d (100 m 3 /h) corresponding to a water consumption for 50000 capita following the Moroccan standards in rural medium. The design of the plant was carried out based on the experimental results from the first part of the study corresponding to a recovery rate of 83% and 10 bars of pressure. Technically and economically, the work shows that in this case, the NF process appears more suitable than the RO for nitrate removal.
水被硝酸盐污染是一个全球性问题,对人类健康构成严重威胁。摩洛哥是一个水资源有限的国家,地下水几乎占总资源的32%。然而,据估计,这些水资源中有6%的硝酸盐含量超过50毫克/升,这是世界卫生组织(世卫组织)建议的饮用水水平,在一些农业活动高度活跃的地区,硝酸盐含量超过250毫克/升。在本研究的第一部分,实验比较和评估了两种商业膜——反渗透膜和纳滤膜(dowfilmtec)——通过使用真正的半咸淡水去除硝酸盐的效率。总溶解固体(TDS)含量850- 1100mg /l,硝酸盐含量119- 130mg /l。为实现这一目标,讨论了操作条件(压力、回收率)对硝酸盐去除率的影响。计算了各膜的除盐率和能耗,选择了最适合除硝和生产饮用水的膜。本研究中使用的试验装置(由法国公司TIA提供)是一个工业试验装置,有两个模块,配备各种螺旋商业膜,面积为7.6平方米。本研究的第二部分估计了一个硝酸盐去除工厂的生产能力为2400立方米/天(100立方米/小时)的两种膜(纳滤膜和反渗透膜)应用采出水的总成本,这相当于按照摩洛哥农村介质标准的5万人均用水量。该装置的设计是根据第一部分的实验结果进行的,该实验结果对应于回收率为83%,压力为10 bar。在技术和经济上,研究表明,在这种情况下,纳滤工艺比反渗透工艺更适合于硝酸盐的去除。
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引用次数: 7
XRD/HSA-interactions, Hirshfeld analysis, HOMO/LUMO and MEP of new N'-(di(pyridin-2-yl)methylene DFT)benzohydrazide 新型N′-(二(吡啶-2-基)亚甲基DFT)苯并肼的XRD/ hsa相互作用、Hirshfeld分析、HOMO/LUMO和MEP
IF 1.1 Q3 Chemistry Pub Date : 2021-02-14 DOI: 10.48317/IMIST.PRSM/MORJCHEM-V9I1.24349
I. Warad
A new functionalized Schiff base N'-(di(pyridin-2-yl)methylene)benzohydrazide Schiff base (HZSB) was prepared in a high yield via condensation of benzohydrazide with di(pyridin-2-yl)methanone in ethanol solution under reflux condition. The prepared HZSB was characterized by XRD, DFT and computed via Hirshfeld surface analysis (HSA). The measured XRD structural parameters like angles lengths and bonds were matching with their DFT computed relatives.
通过苯甲酰肼与二(吡啶-2-基)甲酮在乙醇溶液中的缩合反应,在回流条件下,以高产率制备了一种新的官能化Schiff碱N’-(二(吡啶2-基)亚甲基)苯甲酰亚胺Schiff碱(HZSB)。通过XRD、DFT对制备的HZSB进行了表征,并通过Hirshfeld表面分析(HSA)进行了计算。测得的XRD结构参数(如角长度和键)与其DFT计算的相关性相匹配。
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引用次数: 1
Removal of Crystal Violet dye from aqueous solutions using chemically activated carbons by H3PO4 activation from corn cobs and Corn roots: kinetic and equilibrium isotherm studies 用化学活性炭从玉米芯和玉米根中通过H3PO4活化去除水溶液中的结晶紫染料:动力学和平衡等温线研究
IF 1.1 Q3 Chemistry Pub Date : 2021-02-14 DOI: 10.48317/IMIST.PRSM/MORJCHEM-V9I2.22099
C. Tcheka, D. Abia, D. Iya-sou, A. L. T. Tamgue
In this study, corn cobs and corn roots, agricultural by-products and wastes, were used as precursors for preparation of powder activated carbons (PAC-CC and PAC-CR) by chemical activation with H 3 PO 4 . Functional groups on the surface of both adsorbents were determined by using ATR−FTIR spectroscopy, while their specific surfaces area were calculated using methylene blue adsorption method . Removal of Crystal Violet (CV) dye from aqueous medium onto both adsorbents was carried out at optimal pH of 10. The pseudo-first order and pseudo-second-order models were used to study adsorption kinetics. The Langmuir and Freundlich, isotherm models were employed to analyze the adsorption isotherm. CV dye molecules-activated carbon surface interaction revealed CV dye’s monolayer formation over activated carbon’s surface and the involvement of chemisorption, as verified by Langmuir isotherm model and pseudo-second order model, respectively. Langmuir maximum adsorption capacity of PAC-CC and PAC-CR for CV dye were 41.80 mg/g and 35.92 mg/g, respectively. From these results, it can be concluded that the activated carbon prepared from corn cobs or roots as precursor can be used as adsorbent for successful removal of dyes in an aqueous medium.
本研究以玉米棒和玉米根、农业副产品和废弃物为原料,通过H3PO4化学活化制备粉末活性炭(PAC-CC和PAC-CR)。用ATR−FTIR光谱法测定了两种吸附剂表面的官能团,用亚甲基蓝吸附法计算了它们的比表面积。将结晶紫(CV)染料从水性介质中去除到两种吸附剂上是在10的最佳pH下进行的。采用拟一阶和拟二阶模型对吸附动力学进行了研究。采用Langmuir和Freundlich等温线模型对吸附等温线进行了分析。Langmuir等温线模型和拟二阶模型分别验证了CV染料分子与活性炭表面的相互作用,揭示了CV染料在活性炭表面形成单层并参与化学吸附。PAC-CC和PAC-CR对CV染料的Langmuir最大吸附量分别为41.80mg/g和35.92mg/g。从这些结果可以得出结论,以玉米芯或根为前体制备的活性炭可以用作吸附剂,成功地去除水介质中的染料。
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引用次数: 2
期刊
Moroccan Journal of Chemistry
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