Pub Date : 2025-12-03DOI: 10.1038/s41575-025-01139-8
Manon Defaye,Yasmin Nasser,Christophe Altier
Chronic abdominal pain is prevalent among individuals with inflammatory bowel disease (IBD). Substantial progress has been made in the past few decades in understanding how pain signals travel from the gut to the brain. Preclinical studies have greatly contributed to uncovering the mechanisms of chronic pain in IBD. However, practical applications in clinical settings are still lacking. In this Review, we present the current understanding of the pathological mechanisms of chronic pain in IBD. We explore the neuroplastic changes that occur along the afferent pain pathway from the nerve endings in the colonic mucosa to the brain. We explore the importance of new variables in chronic IBD pain, including the influence of host-microbe interactions during disease, and the effect of comorbid psychological factors, including stress and anxiety, in triggering pain. Finally, we discuss gaps in treatment strategies while proposing new directions for research to identify novel priorities that could pave the way for effective pain therapies.
{"title":"Mechanisms of chronic abdominal pain in inflammatory bowel disease and implications for treatment.","authors":"Manon Defaye,Yasmin Nasser,Christophe Altier","doi":"10.1038/s41575-025-01139-8","DOIUrl":"https://doi.org/10.1038/s41575-025-01139-8","url":null,"abstract":"Chronic abdominal pain is prevalent among individuals with inflammatory bowel disease (IBD). Substantial progress has been made in the past few decades in understanding how pain signals travel from the gut to the brain. Preclinical studies have greatly contributed to uncovering the mechanisms of chronic pain in IBD. However, practical applications in clinical settings are still lacking. In this Review, we present the current understanding of the pathological mechanisms of chronic pain in IBD. We explore the neuroplastic changes that occur along the afferent pain pathway from the nerve endings in the colonic mucosa to the brain. We explore the importance of new variables in chronic IBD pain, including the influence of host-microbe interactions during disease, and the effect of comorbid psychological factors, including stress and anxiety, in triggering pain. Finally, we discuss gaps in treatment strategies while proposing new directions for research to identify novel priorities that could pave the way for effective pain therapies.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"29 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145664279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-28DOI: 10.1038/s41575-025-01157-6
Rupa Banerjee
The year 2025 has seen a pivotal shift in inflammatory bowel disease research, from therapeutic management to prevention. Emerging evidence emphasizes the ‘3 Ps’ shaping future care — prevention, pre-diagnosis and participation — focusing on dietary risk modification, early biomarker detection and multisectoral engagement to advance proactive, population-level inflammatory bowel disease prevention. In summary, 2025 has seen a shift in focus from pure therapeutic management to active disease prevention. The message is unambiguous. The next breakthrough in IBD will not emerge solely from new drugs or biologics, but from reimagining how we live, eat and engage with the microbial ecosystems that define our health.
{"title":"The 3 Ps of IBD today — prevention, pre-diagnosis and participation","authors":"Rupa Banerjee","doi":"10.1038/s41575-025-01157-6","DOIUrl":"10.1038/s41575-025-01157-6","url":null,"abstract":"The year 2025 has seen a pivotal shift in inflammatory bowel disease research, from therapeutic management to prevention. Emerging evidence emphasizes the ‘3 Ps’ shaping future care — prevention, pre-diagnosis and participation — focusing on dietary risk modification, early biomarker detection and multisectoral engagement to advance proactive, population-level inflammatory bowel disease prevention. In summary, 2025 has seen a shift in focus from pure therapeutic management to active disease prevention. The message is unambiguous. The next breakthrough in IBD will not emerge solely from new drugs or biologics, but from reimagining how we live, eat and engage with the microbial ecosystems that define our health.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"23 2","pages":"119-121"},"PeriodicalIF":51.0,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145611396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-24DOI: 10.1038/s41575-025-01147-8
Mihael Vucur, Vangelis Kondylis, Petr Broz, Tom Luedde
{"title":"Regulated necrosis at the crossroads of liver inflammation and cancer development","authors":"Mihael Vucur, Vangelis Kondylis, Petr Broz, Tom Luedde","doi":"10.1038/s41575-025-01147-8","DOIUrl":"https://doi.org/10.1038/s41575-025-01147-8","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"107 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145583190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-24DOI: 10.1038/s41575-025-01149-6
Frances Lee, Meena B. Bansal
{"title":"Liver disease in people living with HIV infection: a changing landscape","authors":"Frances Lee, Meena B. Bansal","doi":"10.1038/s41575-025-01149-6","DOIUrl":"https://doi.org/10.1038/s41575-025-01149-6","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"15 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145583188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fostering equity for women in gastroenterology - a United European Gastroenterology call.","authors":"Eleni Manthopoulou,Ignacio Catalan-Serra,Carolina Ciacci","doi":"10.1038/s41575-025-01155-8","DOIUrl":"https://doi.org/10.1038/s41575-025-01155-8","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"129 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145545247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1038/s41575-025-01143-y
Abdullah K. Malik, Daniel Geh, Thomas R. Jeffry Evans, Pierce K. H. Chow, Derek A. Mann, Steven A. White
{"title":"Improving surgical treatments for hepatocellular carcinoma","authors":"Abdullah K. Malik, Daniel Geh, Thomas R. Jeffry Evans, Pierce K. H. Chow, Derek A. Mann, Steven A. White","doi":"10.1038/s41575-025-01143-y","DOIUrl":"https://doi.org/10.1038/s41575-025-01143-y","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"31 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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