Pub Date : 2025-11-27DOI: 10.1038/s41584-025-01329-3
Fabian Proft, Andre L. Ribeiro, Shikha Singla, Vinod Chandran, Wilson Liao, Christine Lindsay, Enrique R. Soriano, Tina Bhutani, Atul Deodhar, Kurt de Vlam, Lihi Eder, Mitsumasa Kishimoto, Ying Ying Leung, Ennio Lubrano, Dennis McGonagle, Denis Poddubnyy, Laura Savage, Filip Van den Bosch, Philip Mease
{"title":"Consensus definitions of complex-to-manage and treatment-refractory psoriatic arthritis: a GRAPPA initiative","authors":"Fabian Proft, Andre L. Ribeiro, Shikha Singla, Vinod Chandran, Wilson Liao, Christine Lindsay, Enrique R. Soriano, Tina Bhutani, Atul Deodhar, Kurt de Vlam, Lihi Eder, Mitsumasa Kishimoto, Ying Ying Leung, Ennio Lubrano, Dennis McGonagle, Denis Poddubnyy, Laura Savage, Filip Van den Bosch, Philip Mease","doi":"10.1038/s41584-025-01329-3","DOIUrl":"https://doi.org/10.1038/s41584-025-01329-3","url":null,"abstract":"","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"7 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145608735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1038/s41584-025-01328-4
Joshua Heerey, Joanne Kemp, Pim van Klij, Vasco Mascarenhas, Mark Scholes, Fleur Boel, Paul Dijkstra, Kay Crossley, Sita Bierma-Zeinstra, Rintje Agricola
{"title":"Cam morphology and the development of femoroacetabular impingement syndrome and hip osteoarthritis","authors":"Joshua Heerey, Joanne Kemp, Pim van Klij, Vasco Mascarenhas, Mark Scholes, Fleur Boel, Paul Dijkstra, Kay Crossley, Sita Bierma-Zeinstra, Rintje Agricola","doi":"10.1038/s41584-025-01328-4","DOIUrl":"https://doi.org/10.1038/s41584-025-01328-4","url":null,"abstract":"","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"13 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145599896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1038/s41584-025-01335-5
Holly Webster
{"title":"Positive phase II trial of IL-17A–IL-17F-targeting nanobody sonelokimab for PsA","authors":"Holly Webster","doi":"10.1038/s41584-025-01335-5","DOIUrl":"https://doi.org/10.1038/s41584-025-01335-5","url":null,"abstract":"","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"98 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145599341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-24DOI: 10.1038/s41584-025-01326-6
Rebecca H. Haberman, Alexis Ogdie, Joseph F. Merola, Jose U. Scher, Lihi Eder
{"title":"The obesity–inflammation axis in psoriatic disease: mechanisms and therapeutic strategies","authors":"Rebecca H. Haberman, Alexis Ogdie, Joseph F. Merola, Jose U. Scher, Lihi Eder","doi":"10.1038/s41584-025-01326-6","DOIUrl":"https://doi.org/10.1038/s41584-025-01326-6","url":null,"abstract":"","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"100 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145583189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1038/s41584-025-01321-x
George A Robinson,Andrea Knight,Lori B Tucker,Alexandre Belot,David A Isenberg,Coziana Ciurtin
Childhood-onset systemic lupus erythematosus (SLE) is associated with more active disease trajectories, increased cardiovascular risk, earlier development of organ damage (which commonly affects the kidney, central nervous and musculoskeletal systems) and increased use of glucocorticoids and immunosuppressive treatments than adult-onset SLE. However, the understanding of immunopathogenic mechanisms in childhood-onset SLE is far less established than in adult-onset disease. Technological advances over the past decade have accelerated progress in understanding the immune, genetic, epigenetic, metabolic and proteomic profiles of childhood-onset SLE, and have also established the mechanistic roles of immune dysregulation, interferon signalling, biological sex, gender and ethnicity in shaping disease heterogeneity. These insights have led to the elucidation of the mechanisms that drive the increased severity of childhood-onset SLE and point towards new pathways for personalized therapeutic approaches aimed at improving long-term outcomes and quality of life for patients.
{"title":"Insights into the pathogenesis of childhood-onset SLE in the past decade.","authors":"George A Robinson,Andrea Knight,Lori B Tucker,Alexandre Belot,David A Isenberg,Coziana Ciurtin","doi":"10.1038/s41584-025-01321-x","DOIUrl":"https://doi.org/10.1038/s41584-025-01321-x","url":null,"abstract":"Childhood-onset systemic lupus erythematosus (SLE) is associated with more active disease trajectories, increased cardiovascular risk, earlier development of organ damage (which commonly affects the kidney, central nervous and musculoskeletal systems) and increased use of glucocorticoids and immunosuppressive treatments than adult-onset SLE. However, the understanding of immunopathogenic mechanisms in childhood-onset SLE is far less established than in adult-onset disease. Technological advances over the past decade have accelerated progress in understanding the immune, genetic, epigenetic, metabolic and proteomic profiles of childhood-onset SLE, and have also established the mechanistic roles of immune dysregulation, interferon signalling, biological sex, gender and ethnicity in shaping disease heterogeneity. These insights have led to the elucidation of the mechanisms that drive the increased severity of childhood-onset SLE and point towards new pathways for personalized therapeutic approaches aimed at improving long-term outcomes and quality of life for patients.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"49 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145545246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-18DOI: 10.1038/s41584-025-01330-w
Holly Webster
{"title":"cPLA2 as a therapeutic target in chondrocytes for OA and IVDD","authors":"Holly Webster","doi":"10.1038/s41584-025-01330-w","DOIUrl":"https://doi.org/10.1038/s41584-025-01330-w","url":null,"abstract":"","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"107 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145536431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1038/s41584-025-01331-9
Mandana Nikpour, Kathleen Morrisroe, Alicia Calderone, Deborah Yates, Alan Silman
{"title":"Author Correction: Occupational dust and chemical exposures and the development of autoimmune rheumatic diseases","authors":"Mandana Nikpour, Kathleen Morrisroe, Alicia Calderone, Deborah Yates, Alan Silman","doi":"10.1038/s41584-025-01331-9","DOIUrl":"https://doi.org/10.1038/s41584-025-01331-9","url":null,"abstract":"","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"1 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1038/s41584-025-01323-9
Martina Rauner, Aline Bozec
{"title":"Mechanisms of osteoclast activation in inflammatory bone loss in rheumatoid arthritis","authors":"Martina Rauner, Aline Bozec","doi":"10.1038/s41584-025-01323-9","DOIUrl":"https://doi.org/10.1038/s41584-025-01323-9","url":null,"abstract":"","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"222 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145498235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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