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One health concept, prevalence and phenotypic antibiotic susceptibility of Escherichia coli and Salmonella isolated from meats sold in Lagos, Nigeria 从尼日利亚拉各斯出售的肉类中分离出的大肠杆菌和沙门氏菌的一种健康概念、流行率和表型抗生素敏感性
Pub Date : 2023-11-04 DOI: 10.17352/jfsnt.000044
IO Adebesin, IO Sule, KT Kolapo, SO Amoka, CR Olomoko, OH Olubunmi
This study reports the one health concept, prevalence, and antimicrobial susceptibility patterns of Salmonella and Escherichia coli isolated from raw and ready-to-eat (RTE) meats sold in cities of Lagos State, Nigeria. The conventional method of isolation was used to isolate E. coli and Salmonella spp. on their respective selective media from fifty meat samples obtained from abattoirs, open display, and packaged products at various locations in the state and was confirmed by Gram’s reaction and biochemical tests. Thirty-three E. coli and Twenty-seven Salmonella spp. were isolated with the overall prevalence rate recorded as 72% and 68% respectively. The isolated bacteria were subjected to antimicrobial susceptibility testing on nine different antibiotics using the agar disc diffusion method. All the Salmonella were resistant to at least one antibiotic while two E. coli isolates showed susceptibility to all the antibiotics used in this study. Of the 33 E. coli subjected to antimicrobial testing, 84.8% were susceptible to gentamicin, 81.8% susceptible to ciprofloxacin, and 75.8% susceptible to Augmentin. A lower susceptibility pattern was observed on Salmonella with 74.1% of the Salmonella being susceptible to ciprofloxacin and gentamicin, and 70.4% susceptible to azithromycin. Gentamicin was the most effective antibiotic while amoxicillin was found to be least effective against E. coli and Salmonella isolated from the meat samples used in this study. The multiple antibiotic resistance (MAR) index of Salmonella ranged between 0.11-0.67 while E. coli ranged between 0-0.89. E. coli was found to be more resistant than Salmonella and the bacteria isolated from RTE meats showed higher MAR than those isolated from raw meats.
本研究报告了从尼日利亚拉各斯州各城市出售的生肉和即食肉中分离出的沙门氏菌和大肠埃希氏菌的健康概念、流行率和抗菌药敏感性模式。采用传统的分离方法,在各自的选择性培养基上从该州不同地点的屠宰场、露天展示和包装产品中获得的 50 个肉类样本中分离出大肠杆菌和沙门氏菌,并通过革兰氏反应和生化试验进行了确认。结果分离出 33 种大肠杆菌和 27 种沙门氏菌,总感染率分别为 72% 和 68%。利用琼脂盘扩散法,对分离出的细菌进行了九种不同抗生素的抗菌药敏感性测试。所有沙门氏菌至少对一种抗生素具有抗药性,而分离出的两株大肠杆菌则对本研究中使用的所有抗生素都具有敏感性。在进行抗菌测试的 33 个大肠杆菌中,84.8% 对庆大霉素敏感,81.8% 对环丙沙星敏感,75.8% 对奥门菌素敏感。沙门氏菌的敏感性较低,74.1%的沙门氏菌对环丙沙星和庆大霉素敏感,70.4%的沙门氏菌对阿奇霉素敏感。庆大霉素是最有效的抗生素,而阿莫西林对大肠杆菌和沙门氏菌最无效。沙门氏菌的多重抗生素耐药性(MAR)指数介于 0.11-0.67 之间,而大肠杆菌则介于 0-0.89 之间。研究发现,大肠杆菌的抗药性比沙门氏菌强,从即食肉类中分离出来的细菌比从生肉中分离出来的细菌表现出更高的耐药性。
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引用次数: 0
Enhancing immunity against carcinogens through probiotics: A literature review 通过益生菌增强对致癌物质的免疫力:文献综述
Pub Date : 2023-06-27 DOI: 10.17352/jfsnt.000043
Attarianshandiz Massoud
This literature review explores various aspects of using probiotics as a dietary practice to mitigate the effects of toxic compounds. The discussion highlights the importance of considering factors such as timing and composition of probiotic consumption for maximum benefits. Studies have demonstrated the potential of probiotics to inhibit Deoxyribonucleic Acid (DNA) damage and reduce the occurrence of aberrant crypts in animal models when administered before exposure to toxicants. Furthermore, probiotics have been found to metabolize genotoxic compounds into inactive forms, indicating their potential role in detoxification processes. The binding activity of probiotics against toxicants has been widely studied, but there is a need for further research on the metabolites produced during these interactions. Additionally, the presence of other compounds in the food matrix and their competitive effects on probiotic binding should be investigated to understand the full picture. The strain-dependent nature of the probiotic activity and the variability of their antimutagenic properties for different mutagens further highlight the complexity of their functionality. Considering these findings, it is recommended to conduct a careful risk assessment to evaluate the safety of probiotics and their metabolites, taking into account the potential risks and benefits associated with their use. This will help ensure the responsible application of probiotics in food safety and human health initiatives.
这篇文献综述探讨了使用益生菌作为一种饮食实践的各个方面,以减轻有毒化合物的影响。讨论强调了考虑诸如益生菌消费的时间和组成等因素以获得最大效益的重要性。研究表明,在动物模型中,在暴露于毒物之前给药益生菌具有抑制脱氧核糖核酸(DNA)损伤和减少异常隐窝发生的潜力。此外,益生菌已被发现代谢成无活性形式的遗传毒性化合物,表明它们在解毒过程中的潜在作用。益生菌对毒物的结合活性已被广泛研究,但在这些相互作用过程中产生的代谢物还需要进一步研究。此外,食物基质中其他化合物的存在及其对益生菌结合的竞争性影响应该进行调查,以了解全面情况。益生菌活性的菌株依赖性及其对不同诱变剂的抗诱变特性的可变性进一步突出了其功能的复杂性。考虑到这些发现,建议进行仔细的风险评估,以评估益生菌及其代谢物的安全性,同时考虑使用益生菌的潜在风险和益处。这将有助于确保益生菌在食品安全和人类健康倡议中的负责任地应用。
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引用次数: 0
Effects of a nutraceutical combining green tea extract, vitamin C, D, and zinc in patients with post-COVID conditions 结合绿茶提取物、维生素C、D和锌的营养保健品对covid后患者的影响
Pub Date : 2023-05-03 DOI: 10.17352/jfsnt.000042
Liu Chian-Yi, Hsieh Chih-Yu, Chang Shih-Heng, Wang Shu-chuan, Lin Chih-Cheng
Tea and ascorbic acid have antioxidative and anti-inflammatory effects, and vitamin D and zinc have immunomodulatory effects. This study investigated the effect of a nutraceutical prescription combining these four nutrients on the blood biochemical markers and the modified C19-YRS questionnaires in patients who had recovered from COVID-19 disease for four months. Analysis of six markers associated with long COVID symptoms, i.e., INR, d-dimer, hs-CRP, NT-ProBNP, IL-6 and IgA, indicated that the nutraceutical could positively affect the values, especially for the inflammatory markers. The physician’s clinical observation and questionnaire analysis reported significant improvements in post-exertional malaise, sleep quality and overall health of the patients. These results suggested that formulated nutraceutical could not only reduces or eliminates the symptom of long COVID, but potentially also prevents reinfection.
茶和抗坏血酸具有抗氧化和抗炎作用,维生素D和锌具有免疫调节作用。本研究考察了联合这四种营养素的营养保健品处方对COVID-19疾病康复4个月患者血液生化指标和修改后的C19-YRS问卷的影响。对INR、d-二聚体、hs-CRP、NT-ProBNP、IL-6、IgA等6个与COVID长时间症状相关的标志物的分析表明,营养保健品对这些指标有积极影响,尤其是炎症标志物。医生的临床观察和问卷分析显示,患者在运动后不适、睡眠质量和整体健康方面有显著改善。这些结果表明,配方保健品不仅可以减轻或消除长冠症状,而且可以预防再感染。
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引用次数: 0
The human gut fungiome: Role in physiology and detoxification 人体肠道菌群:生理和解毒作用
Pub Date : 2023-05-02 DOI: 10.17352/jfsnt.000041
Seralini Gilles-Eric
The intestinal microbiota is an ecosystem where bacteria, archaea, viruses, and protists, are entangled, but not alone. We take microbiota as the bacterial community because, in many historical papers, the probes to detect other organisms in the intestine were rarely used. But in addition, unicellular fungi or yeasts do exist in microbiota, their assembly is called the mycome or fungiome, and it can reach the size and number of our human cells. The bacteria are far more numerous. For a long time, the whole was taken for a nest of pathogens, but in fact, yeasts adapted and evolved as symbiotic cells helping not only our digestion, but also angiogenesis, tissue growth, vitamin synthesis, and our nervous, endocrine, immune systems and even our detoxification system. Much of what we swallow is or will become fermented, like bread, cheese, or wine. Since the beginning of agriculture, our food is eaten lightly by microbiota including yeasts first in plants not treated by pesticides. Natural yeasts still unknown are in hundreds of types or species at the very least, bringing in particular during their work of fermentation a multiplicity of aromas that play a role in the famous detoxification; but the usual diet only provides a few strains of these yeasts. In yeasts like in all cells, ubiquitous cytochrome P450 detoxifying enzymes form a vast family also involved in cell respiration, which is stimulated to some extent by the aromas and other signals secreted. Yeasts could attract and coordinate bacteria to eliminate in part chemical pollutants.
肠道微生物群是一个生态系统,细菌、古细菌、病毒和原生生物相互纠缠,但并不孤单。我们将微生物群作为细菌群落,是因为在许多历史文献中,很少使用探针来检测肠道中的其他生物。但除此之外,单细胞真菌或酵母确实存在于微生物群中,它们的组合被称为myome或fungiome,它可以达到我们人类细胞的大小和数量。细菌的数量要多得多。很长一段时间以来,整个酵母都被认为是病原体的巢穴,但事实上,酵母适应并进化为共生细胞,不仅帮助我们的消化,还帮助血管生成、组织生长、维生素合成,以及我们的神经、内分泌、免疫系统,甚至是我们的排毒系统。我们吞下的很多东西已经或将要发酵,比如面包、奶酪或葡萄酒。自从农业开始以来,我们的食物被微生物群轻微地吃掉,包括酵母,首先是在未经杀虫剂处理的植物中。天然酵母至少有数百种类型或种类,它们在发酵过程中会产生多种香气,在著名的解毒过程中发挥作用;但通常的饮食只提供这些酵母的少数菌株。与所有细胞一样,在酵母中,无处不在的细胞色素P450解毒酶组成了一个庞大的家族,也参与细胞呼吸,并在一定程度上受到分泌的香气和其他信号的刺激。酵母可以吸引和协调细菌来消除部分化学污染物。
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引用次数: 0
Review on the prevalence and economic importance of camel tuberculosis in Ethiopia 埃塞俄比亚骆驼结核病的流行和经济重要性综述
Pub Date : 2022-12-01 DOI: 10.17352/jfsnt.000040
Duguma Merga Firdisa
Camel tuberculosis is a chronic disease, which is portrayed by the development of granulomas, essentially in the respiratory tract and related lymph nodes, from which the mycobacteria are discharged and contaminate other susceptible animals. Camel tuberculosis has public health implications, especially in pastoral areas of Ethiopia due to the communities having the habit of consuming raw milk and its products and those who do have consistent or day-to-day contact with their camels. In the pastoral areas of Ethiopia, the camel is the spine of their everyday life and extraordinarily adjusted to cruel conditions camels are for the most part raised in Afar, Somali, and Oromia (Borena, Kereyu and Guji). Camels have a high contribution to the economic development of the country. The pastoral community utilized camel products, such as milk and meat, and used camels for various purposes for example, for transportation, drafting, ploughing land, festivity and rivalry as in dashing. In most parts of Ethiopia, camel milk is accepted as a treatment for gastritis, asthmatics, stomach inconvenience, HIV, Hamot (kar), tuberculosis, fever, urinary issues and hepatitis. Among significant illnesses, tuberculosis is one of the principles, which influence camel’s Health and has a zoonotic impact. In addition to this, the etiological agents are transmitted to humans through an aerogenous route from those animals with active cases in the herd. The infection has been reported from several parts of pastoral areas of the country essentially dependent on tuberculin tests and abattoir inspections. Therefore, attention should be given to the control of tuberculosis in livestock; public health education on the zoonotic importance of the disease or awareness creation and the national tuberculosis control needs to consider the one health approach and further epidemiological studies should be undertaken.
骆驼结核病是一种慢性疾病,表现为肉芽肿的形成,主要发生在呼吸道和相关淋巴结,分枝杆菌从那里排出并污染其他易感动物。骆驼结核病具有公共卫生影响,特别是在埃塞俄比亚的牧区,因为有食用生牛奶及其产品的习惯的社区以及经常或每天与骆驼接触的社区。在埃塞俄比亚的牧区,骆驼是他们日常生活的支柱,在严酷的环境下,骆驼大多在阿法尔、索马里和奥罗米亚(博雷纳、凯雷尤和古吉)饲养。骆驼对国家的经济发展有很大的贡献。畜牧社会利用骆驼的产品,如牛奶和肉,并将骆驼用于各种目的,例如运输,绘图,耕地,节日和比赛(如赛跑)。在埃塞俄比亚的大部分地区,骆驼奶被认为是治疗胃炎、哮喘、胃部不适、艾滋病毒、肺结核、发烧、泌尿系统问题和肝炎的一种方法。在重大疾病中,结核病是影响骆驼健康的主要疾病之一,具有人畜共患的影响。除此之外,致病因子通过空气传播途径从畜群中有活动性病例的动物传播给人类。据报告,该国牧区若干地区的感染基本上依赖于结核菌素试验和屠宰场检查。因此,应重视家畜结核病的控制;关于该病的人畜共患病重要性的公共卫生教育或提高认识以及国家结核病控制需要考虑统一的保健办法,并应开展进一步的流行病学研究。
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引用次数: 0
Brown fat and a short circuit make warm and slim 棕色脂肪和短路使人温暖和苗条
Pub Date : 2022-12-01 DOI: 10.17352/jfsnt.000039
Doepp Manfred
It is not widely known that the body contains a mechanism that protects against cold and at the same time leads to normal body weight. It is brown fat, combined with a special protein called thermogenin/UCP1. Though there are several UnCoupled Proteins, the main one for the brown tissue is UCP1. It switches ATP production towards heat production. Good oils and cool outside temperatures help in this process.
人体内有一种既能抵御寒冷,又能保持正常体重的机制,这一点并不为人所知。它是棕色脂肪,结合了一种叫做热原/UCP1的特殊蛋白质。虽然有几种解偶联蛋白,但棕色组织的主要蛋白是UCP1。它将ATP的产生转向热的产生。好的油和凉爽的室外温度有助于这个过程。
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引用次数: 0
Overview of Foodborne viruses: Important viruses, outbreaks, health concerns, food Handling and fresh produce 食源性病毒概述:重要的病毒,爆发,健康问题,食品处理和新鲜农产品
Pub Date : 2022-11-23 DOI: 10.17352/jfsnt.000038
Al-Daim Sahar Abd
Foodborne viruses can transmit through food in lots of ways including consuming items of animal origin containing zoonotic viruses, consuming contaminated food handled by infected food workers, and consuming contaminated food produced by humans. Viral foodborne illnesses are now a major contributor to all foodborne illness reports in recent years and are seen as a rising issue to the public health of humans and animals. Noroviruses and hepatitis A viruses were shown to be predominantly linked to the food-handler transmission and sewage-contaminated foods, according to microbiological research. In order to facilitate source attribution and identify risk preventive measures, routine, standard surveillance of viral outbreaks, and surveillance of virus occurrence in food products, combined with systematic strain typing, food and clinical microbiologists, would be advocated.
食源性病毒可通过多种方式通过食物传播,包括食用含有人畜共患病毒的动物源物品,食用受感染食品工人处理的受污染食品,以及食用由人类生产的受污染食品。病毒性食源性疾病现在是近年来所有食源性疾病报告的主要贡献者,并被视为人类和动物公共卫生的一个日益严重的问题。微生物学研究表明,诺如病毒和甲型肝炎病毒主要与食品处理人员传播和污水污染的食品有关。为方便病原溯源和确定风险预防措施,应提倡常规、标准的病毒暴发监测和食品中病毒发生的监测,并结合食品和临床微生物学家的系统菌株分型。
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引用次数: 0
Potential health risk estimation of naturally occurring radionuclides intake due to the consumption of seafood around Coastal zone 海岸带附近海产品摄入天然放射性核素的潜在健康风险评估
Pub Date : 2022-09-20 DOI: 10.17352/jfsnt.000037
Pandion Kumar, Arunachalam Kantha Deivi
As part of a regional baseline study, the distribution of naturally occurring radioactive materials in the marine fish diversity consumed by different age group representatives living in the Kalpakkam coastal zone was studied. The average activity of natural radionuclide in 238U, 232Th, and 40K (n = 40) was 28.51, 239.58, and 118.95 Bq kg-1, respectively. The annual dose of ingestion, lifetime carcinogenic risk assessment and cancer risk assessment due to 238U, 232Th, and 40K were estimated by marine fish diversity in children aged 1-4,5-9,10-14,15-17 years, adults, pregnant women, and the fishing community. The Hospital-Based Cancer Registry (HBCR) compares to the coastal zone. Statistical studies such as Pearson correlation analysis, Principle component analysis, and Cluster analysis report check that the current levels of natural radionuclide do not pose a significant radioactivity threat to the residents based on the activity of the radionuclide.
作为区域基线研究的一部分,研究了生活在Kalpakkam沿海地区的不同年龄组代表所食用的海鱼多样性中天然存在的放射性物质的分布。238U、232Th和40K (n = 40)中天然核素的平均活度分别为28.51、239.58和118.95 Bq kg-1。根据1 ~ 4岁、5 ~ 9岁、10 ~ 14岁、15 ~ 17岁儿童、成人、孕妇和渔业社区的海鱼多样性估算238U、232Th和40K的年摄入剂量、终生致癌风险评估和致癌风险评估。以医院为基础的癌症登记处(HBCR)与沿海地区进行比较。Pearson相关分析、主成分分析和聚类分析等统计研究报告根据放射性核素的活度,检查了目前天然放射性核素的水平不会对居民构成重大的放射性威胁。
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引用次数: 0
Health effects of organic farming, review of literature since 2005-Revision 有机农业对健康的影响,2005年以来的文献综述
Pub Date : 2022-09-06 DOI: 10.17352/jfsnt.000036
Groot Maria
In 2005, a study was carried out with chicks fed either organic feed or conventional feed. The aim of the trial was to see whether there was a difference in health between organic and non-organic fed chickens, as a stepping stone to a study in pigs and ultimately in humans. Thus, the final goal was to see whether organic food has positive health effects on humans. In the study, it appeared that animals fed organic feed showed a stronger immune response after a challenge than animals not fed organic feed. However, the researchers found that no firm conclusions could be drawn about the health status of organically fed animals. Based on these results, it was decided not to commission a follow-up study because the differences would be too small. The current knowledge and insights may give new reasons for follow-up research. For this purpose, a report was published with a summary of the original research and subsequent publications, as well as results from literature since 2005 on the health effects of organic feed for animals and organic products for humans. After the 2005 study, no comparable animal studies were carried out with organic and conventional feed. It is precisely in the case of animals that only the feed can differ, which can provide valuable insight into the effects of using only organic nutrition. Research has been done on the differences in composition between conventional and organic products. Human cohort studies have also been conducted on the effects of organic food on health parameters and the occurrence of various types of cancer. Although most researchers are very cautious about concluding the health effects of organic food, there are several relevant findings on differences in the composition of products, most of which are related to the organic production method. These include no synthetic chemical crop protection agents and fewer biocides as compared to conventional production, more antioxidants, and phenols and fewer antibiotic-resistant germs than conventional food. Moreover, milk has a more beneficial fatty acid pattern. There are some indications that eating organic food lowers the risk of developing certain conditions, such as allergies, metabolic syndrome and obesity, and certain cancers.
2005年进行了一项研究,分别用有机饲料和传统饲料喂养雏鸡。该试验的目的是观察有机饲料和非有机饲料喂养的鸡在健康方面是否存在差异,作为在猪身上进行研究并最终在人类身上进行研究的垫脚石。因此,最终目标是观察有机食品是否对人类健康有积极影响。在这项研究中,喂食有机饲料的动物似乎比没有喂食有机饲料的动物在受到攻击后表现出更强的免疫反应。然而,研究人员发现,对于有机饲养的动物的健康状况,无法得出确切的结论。基于这些结果,决定不委托进行后续研究,因为差异太小。现有的知识和见解可能为后续研究提供新的理由。为此,发表了一份报告,概述了最初的研究和随后的出版物,以及2005年以来关于有机饲料对动物和有机产品对人类健康影响的文献结果。在2005年的研究之后,没有对有机饲料和传统饲料进行类似的动物研究。正是在动物的情况下,只有饲料是不同的,这可以为只使用有机营养的影响提供有价值的见解。人们对传统食品和有机食品的成分差异进行了研究。人们还对有机食品对健康参数和各种癌症发生的影响进行了人体队列研究。虽然大多数研究人员对有机食品对健康的影响的结论非常谨慎,但在产品成分的差异方面有一些相关的发现,其中大多数与有机生产方法有关。这包括不使用合成化学作物保护剂,与传统食品相比,杀菌剂更少,抗氧化剂和酚类更多,耐抗生素细菌也比传统食品少。此外,牛奶有更有益的脂肪酸模式。有一些迹象表明,食用有机食品可以降低患某些疾病的风险,比如过敏、代谢综合征、肥胖和某些癌症。
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引用次数: 1
Monkey menace in Kwa Vonza/Yatta Ward, Kitui County, Kenya: Threat to food and nutrition security and sustainable livelihoods 肯尼亚基图伊县Kwa Vonza/Yatta区的猴子威胁:对粮食和营养安全和可持续生计的威胁
Pub Date : 2022-09-02 DOI: 10.17352/jfsnt.000035
Mutavi Sylvester K
Since time immemorial, farmers in the arid and semi-arid lands in Kitui County have had many challenges in attaining food and nutrition security. This is largely attributed to inadequate rains, crop diseases, pests, and crop damage by wild animals among others factors. However, the monkey menace and its threats to food security and sustainable livelihoods in Kitui County are not documented. On this basis, a socio-economic survey was carried out in Kwa Vonza/Yatta ward, Kitui Rural constituency in Kitui County to establish i) the extent of damage by monkeys in the ecosystems ii) socio-economic impacts caused by monkeys iii) mitigation measures employed to control the monkey menace in Kitui rural constituency. The socio-economic survey, using one hundred and fifty (150) respondents, revealed that 65% of the respondents indicated that the monkey menace was a threat to food security, and human and livestock life. The respondents noted that monkeys damage their crops (cereals, fruits, and vegetables) on the farm, kill kids of goats and lambs of sheep, and damage food in stores and kitchens. In extreme cases of dry spells, 25% of the respondents indicated the monkeys caused physical injuries to children when the monkeys are looking for food in their homesteads. The respondents felt that the government, through Kenya wildlife services, should intervene to control the monkey population in the hilly habitats for the farmers to have gainful agricultural production and sustainable livelihoods.
自古以来,基图伊县干旱和半干旱地区的农民在实现粮食和营养安全方面面临许多挑战。这主要是由于降雨不足、作物病虫害和野生动物对作物的破坏等因素造成的。然而,基图伊县的猴子威胁及其对粮食安全和可持续生计的威胁并没有记录在案。在此基础上,在基图伊县基图伊农村选区Kwa Vonza/Yatta区开展了一项社会经济调查,以确定:(1)猴子对生态系统的破坏程度;(2)猴子造成的社会经济影响;(3)为控制基图伊农村选区猴子威胁而采取的缓解措施。对150名受访者进行的社会经济调查显示,65%的受访者表示,猴子的威胁对粮食安全以及人类和牲畜的生命构成威胁。答复者指出,猴子破坏农场的庄稼(谷物、水果和蔬菜),杀死山羊的孩子和绵羊的羊羔,破坏商店和厨房里的食物。在干旱的极端情况下,25%的受访者表示,当猴子在他们的家园寻找食物时,猴子会对儿童造成身体伤害。受访者认为,政府应通过肯尼亚野生动物服务部门进行干预,控制山地栖息地的猴子数量,使农民能够获得有收益的农业生产和可持续的生计。
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引用次数: 0
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Journal of Food Science and Nutrition Therapy
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