Background Androgenetic alopecia (AGA) is associated with the enzyme 5a-reductase and prostaglandin D2, both of which are increased in bald areas of the scalp. We previously demonstrated the safety and efficacy of a topical Ageratum conyzoides (A. conyzoides) formulation in improving hair growth and decreasing hair loss. Objective A follow-up 12-week double-blind, randomised clinical trial investigating the efficacy and safety of A. conyzoides extract in an oral formulation, in males and females over 18-years of age. Methods 250 mg of A. conyzoides or a placebo was supplemented daily over a 12-week period to 84 healthy males or females with hair loss. The primary outcome was hair growth assessed by measuring hair density using HairCheck®, and hairline recession. Hair loss was measured by the mean number of hairs lost in a one-minute combing test and hair/tug pull test. Other assessments included Norwood/Hamilton and Ludwig-Savin scales evaluating male and female pattern baldness, respectively. Biochemical and haematological parameters were also assessed, as change from baseline for each group. Results Twelve (12)-week daily supplementation of A. conyzoides resulted in a significant reduction in hairline recession compared to the placebo group. A trend towards significance was observed for hair density between groups, where hair density increased in the A. conyzoides group and decreased in placebo group from their respective baseline values. No significant differences were found in hair loss measures or the Norwood/Hamilton and Ludwig-Savin scales. A significant difference was found in the change from baseline for total prostaglandins between groups at week 12, with a decrease from baseline in the active group and an increase in the placebo group. In males, a significant difference in the change from baseline was seen for type-2 5a-reductase, with a decrease from baseline in the active group and increase in the placebo group. Conclusion These results demonstrate an improvement in hair growth following the 12-week oral supplementation of A. conyzoides extract., with mechanistic convergence.
{"title":"Efficacy of an Oral Ageratum Conyzoides Formulation on Increasing Hair Growth and Decreasing Hair Loss in Males and Females: A Randomised Double-Blind Placebo-Controlled Study","authors":"P. Clayton, Nathasha Bogoda, Amanda Rao","doi":"10.17140/tcoj-6-119","DOIUrl":"https://doi.org/10.17140/tcoj-6-119","url":null,"abstract":"Background Androgenetic alopecia (AGA) is associated with the enzyme 5a-reductase and prostaglandin D2, both of which are increased in bald areas of the scalp. We previously demonstrated the safety and efficacy of a topical Ageratum conyzoides (A. conyzoides) formulation in improving hair growth and decreasing hair loss. Objective A follow-up 12-week double-blind, randomised clinical trial investigating the efficacy and safety of A. conyzoides extract in an oral formulation, in males and females over 18-years of age. Methods 250 mg of A. conyzoides or a placebo was supplemented daily over a 12-week period to 84 healthy males or females with hair loss. The primary outcome was hair growth assessed by measuring hair density using HairCheck®, and hairline recession. Hair loss was measured by the mean number of hairs lost in a one-minute combing test and hair/tug pull test. Other assessments included Norwood/Hamilton and Ludwig-Savin scales evaluating male and female pattern baldness, respectively. Biochemical and haematological parameters were also assessed, as change from baseline for each group. Results Twelve (12)-week daily supplementation of A. conyzoides resulted in a significant reduction in hairline recession compared to the placebo group. A trend towards significance was observed for hair density between groups, where hair density increased in the A. conyzoides group and decreased in placebo group from their respective baseline values. No significant differences were found in hair loss measures or the Norwood/Hamilton and Ludwig-Savin scales. A significant difference was found in the change from baseline for total prostaglandins between groups at week 12, with a decrease from baseline in the active group and an increase in the placebo group. In males, a significant difference in the change from baseline was seen for type-2 5a-reductase, with a decrease from baseline in the active group and increase in the placebo group. Conclusion These results demonstrate an improvement in hair growth following the 12-week oral supplementation of A. conyzoides extract., with mechanistic convergence.","PeriodicalId":189690,"journal":{"name":"Trichology and Cosmetology – Open Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129491819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective Hidradenitis Suppuravita (HS) is a chronic condition that creates a significant burden on a patient’s life, both physical and emotional. While a broad range of medical and dressing treatments exist for HS, surgery is often considered the only curative approach. The aim of this study is to comprehensively review existing and emerging surgical options available for the treatment of HS. Methods Using the key phrase “Hidradenitis Suppuravita” and the MeSH terms “surgery or surgical” and “treatment or procedure”, a search of the Ovid Medline and Pubmed databases was conducted 2012 to 2022. Forty-eight studies meeting criteria were identified and included in the literature review. Results Many methods exist for the treatment of HS and there have been promising small scale series and reports that highlight positive disease and quality-of-life (QoL) outcomes associated with some surgical treatment modalities. Most methods are centred around excision of all diseased tissue followed by varying methods of reconstruction. Some novel methods, such as laser ablation, are also used. Each method has its own strengths and weaknesses. Selection of method is currently made based on a case-by-case basis such as disease severity, disease location and surgeon preference. Conclusion Further randomised control trials with larger patient populations are needed to quantify the efficacy and safety of the various surgical methods available. These approaches to treatment hold tremendous potential for improving patient outcomes globally.
目的:化脓性汗腺炎(HS)是一种慢性疾病，对患者的生活造成了重大的负担，无论是身体上还是精神上。虽然有各种各样的药物和敷料治疗HS，但手术通常被认为是唯一的治疗方法。本研究的目的是全面审查现有的和新兴的手术选择可用于治疗HS。方法以关键词“Suppuravita Hidradenitis”为检索词，MeSH检索词“surgery or surgical”和“treatment or procedure”检索Ovid Medline和Pubmed数据库2012 - 2022年。48项符合标准的研究被纳入文献综述。结果有许多治疗HS的方法，并且有一些有希望的小规模系列和报告强调了与一些手术治疗方式相关的积极疾病和生活质量(QoL)结果。大多数方法以切除所有病变组织为中心，然后采用不同的重建方法。一些新的方法，如激光烧蚀，也被使用。每种方法都有自己的优点和缺点。目前选择的方法是根据具体情况，如疾病的严重程度，疾病的位置和外科医生的偏好。结论需要更多的随机对照试验来量化各种手术方法的有效性和安全性。这些治疗方法在改善全球患者预后方面具有巨大潜力。
{"title":"Surgical Methods of Management for Hidradenitis Suppurativa: A Narrative Review","authors":"K. Nguyen, Sarah R Adamson, S. Ng","doi":"10.17140/tcoj-5-118","DOIUrl":"https://doi.org/10.17140/tcoj-5-118","url":null,"abstract":"Objective Hidradenitis Suppuravita (HS) is a chronic condition that creates a significant burden on a patient’s life, both physical and emotional. While a broad range of medical and dressing treatments exist for HS, surgery is often considered the only curative approach. The aim of this study is to comprehensively review existing and emerging surgical options available for the treatment of HS. Methods Using the key phrase “Hidradenitis Suppuravita” and the MeSH terms “surgery or surgical” and “treatment or procedure”, a search of the Ovid Medline and Pubmed databases was conducted 2012 to 2022. Forty-eight studies meeting criteria were identified and included in the literature review. Results Many methods exist for the treatment of HS and there have been promising small scale series and reports that highlight positive disease and quality-of-life (QoL) outcomes associated with some surgical treatment modalities. Most methods are centred around excision of all diseased tissue followed by varying methods of reconstruction. Some novel methods, such as laser ablation, are also used. Each method has its own strengths and weaknesses. Selection of method is currently made based on a case-by-case basis such as disease severity, disease location and surgeon preference. Conclusion Further randomised control trials with larger patient populations are needed to quantify the efficacy and safety of the various surgical methods available. These approaches to treatment hold tremendous potential for improving patient outcomes globally.","PeriodicalId":189690,"journal":{"name":"Trichology and Cosmetology – Open Journal","volume":"33 Suppl 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132834947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Botulinum toxin use in aesthetic medicine for treatment of facial rhytids is common and has become more and more popular in India in recent times. Botulinum toxin (BoNT) is produced by clostridium botulinum which is an anaerobic, spore forming, rod shaped bacteria. The botulinum toxin complex contains a 150 KD neurotoxin together with a complex additional protein. The neurotoxin is cleaved by the clostridial proteases into heavy and light chain. The heavy chain (100 KD) after cleavage binds to gangliosides and a protein receptor on the presynaptic nerve ending, whereas the light chain (50 KD) blocks the release of acetylcholine, leading to a dose dependent weakening of the target muscle.
{"title":"Neutralizing Antibodies to Botulinum Toxin Type A as a Secondary Treatment Failure: A Case Report from Mumbai, India","authors":"Narmada Matang Khatri","doi":"10.17140/tcoj-5-117","DOIUrl":"https://doi.org/10.17140/tcoj-5-117","url":null,"abstract":"Botulinum toxin use in aesthetic medicine for treatment of facial rhytids is common and has become more and more popular in India in recent times. Botulinum toxin (BoNT) is produced by clostridium botulinum which is an anaerobic, spore forming, rod shaped bacteria. The botulinum toxin complex contains a 150 KD neurotoxin together with a complex additional protein. The neurotoxin is cleaved by the clostridial proteases into heavy and light chain. The heavy chain (100 KD) after cleavage binds to gangliosides and a protein receptor on the presynaptic nerve ending, whereas the light chain (50 KD) blocks the release of acetylcholine, leading to a dose dependent weakening of the target muscle.","PeriodicalId":189690,"journal":{"name":"Trichology and Cosmetology – Open Journal","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124036124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Whilst the management of burn wounds continue to evolve and improve over the years, folliculitis remains a common sequela in the burned patient.
虽然烧伤创面的管理不断发展和改善，毛囊炎仍然是烧伤患者常见的后遗症。
{"title":"Management of Folliculitis in Burn Patients","authors":"Y. T. Tay, N. Tang, S. Ng","doi":"10.17140/tcoj-5-116","DOIUrl":"https://doi.org/10.17140/tcoj-5-116","url":null,"abstract":"Whilst the management of burn wounds continue to evolve and improve over the years, folliculitis remains a common sequela in the burned patient.","PeriodicalId":189690,"journal":{"name":"Trichology and Cosmetology – Open Journal","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132480815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Bauer, William Clearfield, Rochelle Ramacher, P. Ling, C. Marsland, S. Bell
Objective The American diet is nutrient-poor and rich in unhealthy compounds like sodium, sugar, and saturated fats. Whether food has an effect on appearance has not been fully elucidated. The purpose of this prospective, single-armed study was to evaluate the impact of consuming two nutrient-dense functional foods, which are low in salt, sugar, and saturated fats, on hair, skin, and fingernail health. Methods Both subjective (self-reported questionnaires and photographs) and objective (i.e., salivary pH and skin hydration) tests were used to evaluate appearance. Weekly compliance with nutrient-dense foods, body weight, and quality of life assessment were also recorded. Results Participants(n=28) consumed most of the nutrient-dense foods and remained weight stable, which was the goal of the study to exclude the effect of changes in body weight on appearance. Neither objective measurement of appearance showed significant improvements. Subjective measurements using questionnaires specific to hair, skin, and fingernails improved significantly over the 8-week study. Rating of photographs that the participants took of themselves improved significantly over the 8-weeks. These included reduced redness, decreased pore size, and better skin color. Using an acne-rating scale, a significant improvement was observed at week 8 compared to baseline. The quality of life parameters improved significantly including feeling of well-being, feeling full, having more energy, sleeping better, having less stress, and being more focused. Conclusion Inclusion of two nutrient-rich, functional foods in the diet improved the appearance of hair, skin, and fingernails. These foods were well-received and easy-to-prepare, leading to excellent compliance with the dietary protocol.
{"title":"Nutrient-Dense, Functional Foods Enhance Hair, Skin, and Nail Appearance","authors":"K. Bauer, William Clearfield, Rochelle Ramacher, P. Ling, C. Marsland, S. Bell","doi":"10.17140/tcoj-4-114","DOIUrl":"https://doi.org/10.17140/tcoj-4-114","url":null,"abstract":"Objective The American diet is nutrient-poor and rich in unhealthy compounds like sodium, sugar, and saturated fats. Whether food has an effect on appearance has not been fully elucidated. The purpose of this prospective, single-armed study was to evaluate the impact of consuming two nutrient-dense functional foods, which are low in salt, sugar, and saturated fats, on hair, skin, and fingernail health. Methods Both subjective (self-reported questionnaires and photographs) and objective (i.e., salivary pH and skin hydration) tests were used to evaluate appearance. Weekly compliance with nutrient-dense foods, body weight, and quality of life assessment were also recorded. Results Participants(n=28) consumed most of the nutrient-dense foods and remained weight stable, which was the goal of the study to exclude the effect of changes in body weight on appearance. Neither objective measurement of appearance showed significant improvements. Subjective measurements using questionnaires specific to hair, skin, and fingernails improved significantly over the 8-week study. Rating of photographs that the participants took of themselves improved significantly over the 8-weeks. These included reduced redness, decreased pore size, and better skin color. Using an acne-rating scale, a significant improvement was observed at week 8 compared to baseline. The quality of life parameters improved significantly including feeling of well-being, feeling full, having more energy, sleeping better, having less stress, and being more focused. Conclusion Inclusion of two nutrient-rich, functional foods in the diet improved the appearance of hair, skin, and fingernails. These foods were well-received and easy-to-prepare, leading to excellent compliance with the dietary protocol.","PeriodicalId":189690,"journal":{"name":"Trichology and Cosmetology – Open Journal","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126021993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vincenzo Nobile, F. Tursi, Enza Cestone, R. Sergheraert, J. Duperray
Background Telogen effluvium (TE) and its acute form (aTE) are two of the commonest occurrences in a trichology clinic, with patients claiming excessive hair shedding. ATE can occur in people of any age and ethnicity and is considered to be a quite common condition in either sex even if women are more likely to have a lowered quality of life and restricted social contacts as compared to men as a result of hair loss. Brittle nail syndrome (BNS) is a common condition affecting up to 20% of the population, especially women over 50 years of age. Nails affected by BNS appear ragged, thin, and dull. The clinical features of BNS include horizontal splits within the nail plate (onychoschizia) and increased longitudinal ridging or splitting (onychorrhexis). In BNS oral supplementation, trace elements and amino acids (especially L-Cystine) have been reported to be useful to ameliorate the nail plate condition. Objective We hypothesized that a nutritional approach, with nutrients of which the composition is close to the human keratin, could be effective to decrease hair loss during telogen effluvium and to improve brittle nails condition. At this purpose, a clinical study was designed to investigate the efficacy of a natural keratin hydrolysate obtained from a non-human source (feathers) on both aTE and BNS. Methods The in vivo effects of a natural keratin hydrolysate, Kera-Diet® (KD) upon human hair and nails condition was tested in a randomized, double-blind, parallel-group, benchmark (BE) and placebo (PL) controlled study involving 60 women during 90 days. In all subjects, Anagen/Telogen hair, hair volume and density, pull test, global photography, hair and nails brightness, and nail plate growth were measured at baseline and after 45 and 90 days of products use. A self-assessment test was carried out at the end of the study. Results With the KD treatment group, hair density, percentage of hair in anagen phase, hair and nails brightness, and nails growth were significantly increased compared to PL treatment group. Interestingly, with this same group, the diagnosis of aTE by pull testing was negative from 45 days. The efficacy of KD was equal to or greater than PL treatment group. Conclusion In this study, we demonstrated that daily oral administration of 1000 mg during 3 months of a natural extensively keratin hydrolysate, Kera-Diet®, associated to trace elements and specific vitamins was effective to improve both hair and nails condition. Furthermore, it demonstrates the role of nutrients in both aTE and BNS.
{"title":"The Effects of the Oral Supplementation with a Natural Keratin Hydrolysate (Kera-Diet®) on Hair and Nails: Randomized, Placebo and Benchmark-Controlled Clinical Trial on Healthy Females","authors":"Vincenzo Nobile, F. Tursi, Enza Cestone, R. Sergheraert, J. Duperray","doi":"10.17140/tcoj-4-115","DOIUrl":"https://doi.org/10.17140/tcoj-4-115","url":null,"abstract":"Background Telogen effluvium (TE) and its acute form (aTE) are two of the commonest occurrences in a trichology clinic, with patients claiming excessive hair shedding. ATE can occur in people of any age and ethnicity and is considered to be a quite common condition in either sex even if women are more likely to have a lowered quality of life and restricted social contacts as compared to men as a result of hair loss. Brittle nail syndrome (BNS) is a common condition affecting up to 20% of the population, especially women over 50 years of age. Nails affected by BNS appear ragged, thin, and dull. The clinical features of BNS include horizontal splits within the nail plate (onychoschizia) and increased longitudinal ridging or splitting (onychorrhexis). In BNS oral supplementation, trace elements and amino acids (especially L-Cystine) have been reported to be useful to ameliorate the nail plate condition. Objective We hypothesized that a nutritional approach, with nutrients of which the composition is close to the human keratin, could be effective to decrease hair loss during telogen effluvium and to improve brittle nails condition. At this purpose, a clinical study was designed to investigate the efficacy of a natural keratin hydrolysate obtained from a non-human source (feathers) on both aTE and BNS. Methods The in vivo effects of a natural keratin hydrolysate, Kera-Diet® (KD) upon human hair and nails condition was tested in a randomized, double-blind, parallel-group, benchmark (BE) and placebo (PL) controlled study involving 60 women during 90 days. In all subjects, Anagen/Telogen hair, hair volume and density, pull test, global photography, hair and nails brightness, and nail plate growth were measured at baseline and after 45 and 90 days of products use. A self-assessment test was carried out at the end of the study. Results With the KD treatment group, hair density, percentage of hair in anagen phase, hair and nails brightness, and nails growth were significantly increased compared to PL treatment group. Interestingly, with this same group, the diagnosis of aTE by pull testing was negative from 45 days. The efficacy of KD was equal to or greater than PL treatment group. Conclusion In this study, we demonstrated that daily oral administration of 1000 mg during 3 months of a natural extensively keratin hydrolysate, Kera-Diet®, associated to trace elements and specific vitamins was effective to improve both hair and nails condition. Furthermore, it demonstrates the role of nutrients in both aTE and BNS.","PeriodicalId":189690,"journal":{"name":"Trichology and Cosmetology – Open Journal","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134448758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lichen nitidus (LN) is an entity of unknown etiology, with typical morphology and histology. Actinic lichen nitidus (ALN) is rare. It presents as typical lesions of LN in photodistribution, with classical histology. Dermoscopic findings in LN has been documented in very few cases in literature. We present a case of ALN with koebnerization, characteristic histology and dermoscopic features. Dermoscopy revealed round, bluish white streaks in “fern leaf ” pattern in the background of brownish reticular network. Our patient responded well to hydroxychloroquine and photoprotection.
{"title":"Actinic Lichen Nitidus with Dermoscopic Features, and Response to Hydroxychloroquine","authors":"S. Shrestha, Aditi Mishra","doi":"10.17140/tcoj-1-112","DOIUrl":"https://doi.org/10.17140/tcoj-1-112","url":null,"abstract":"Lichen nitidus (LN) is an entity of unknown etiology, with typical morphology and histology. Actinic lichen nitidus (ALN) is rare. It presents as typical lesions of LN in photodistribution, with classical histology. Dermoscopic findings in LN has been documented in very few cases in literature. We present a case of ALN with koebnerization, characteristic histology and dermoscopic features. Dermoscopy revealed round, bluish white streaks in “fern leaf ” pattern in the background of brownish reticular network. Our patient responded well to hydroxychloroquine and photoprotection.","PeriodicalId":189690,"journal":{"name":"Trichology and Cosmetology – Open Journal","volume":"395 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121779262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandre Gonçalves de Meirelles, M. Moura-Fernandes, E. Moreira-Marconi, T. R. Lemos-Santos, Gefferson da Silva-Costa, Sérgio Oliveira de-Carvalho, Ivana de Cássia Araújo Ventura, Ygor Teixeira-Silva, Laisa Liane Paineiras-Domingos, Danúbia da Cunha de Sá-Caputo, M. Bernardo-Filho
Introduction The physical inactivity has been identified as the fourth leading risk factor for mortality in the world. Physical activity may exert beneficial influence on the cardiovascular system, besides to bring benefits to the lipid metabolism, the increase of the lean mass, and the increase of the basal metabolism. As a response of the physical activity, the concentration of several hormones is altered, as the cortisol. Different specimens are used to determination of concentration of the cortisol, like saliva, urine, blood samples and hair. The aim of this narrative review is to present scientific information about the use of the hair to evaluate the concentration of cortisol in individuals that have performed physical activity. Materials and Methods Publications were accessed in the database PubMed September 12th, 2018 using the keywords hair and “physical activity” and cortisol. Results In general, it was found that the hair can be used to determine the concentration of cortisol in different populations. Conclusions In conclusion, all the considerations of this review, it is possible to conclude that the hair can be used successfully, as a specimen, to determine the concentration of the cortisol in the body. This would have an importance to verify the response of the hypothalamus-pituitary-adrenocortical axis to the physical activity.
{"title":"Hair as a Specimen to Determine the Concentration of Cortisol Levels in Individuals that have Performed Physical Activity","authors":"Alexandre Gonçalves de Meirelles, M. Moura-Fernandes, E. Moreira-Marconi, T. R. Lemos-Santos, Gefferson da Silva-Costa, Sérgio Oliveira de-Carvalho, Ivana de Cássia Araújo Ventura, Ygor Teixeira-Silva, Laisa Liane Paineiras-Domingos, Danúbia da Cunha de Sá-Caputo, M. Bernardo-Filho","doi":"10.17140/tcoj-3-110","DOIUrl":"https://doi.org/10.17140/tcoj-3-110","url":null,"abstract":"Introduction The physical inactivity has been identified as the fourth leading risk factor for mortality in the world. Physical activity may exert beneficial influence on the cardiovascular system, besides to bring benefits to the lipid metabolism, the increase of the lean mass, and the increase of the basal metabolism. As a response of the physical activity, the concentration of several hormones is altered, as the cortisol. Different specimens are used to determination of concentration of the cortisol, like saliva, urine, blood samples and hair. The aim of this narrative review is to present scientific information about the use of the hair to evaluate the concentration of cortisol in individuals that have performed physical activity. Materials and Methods Publications were accessed in the database PubMed September 12th, 2018 using the keywords hair and “physical activity” and cortisol. Results In general, it was found that the hair can be used to determine the concentration of cortisol in different populations. Conclusions In conclusion, all the considerations of this review, it is possible to conclude that the hair can be used successfully, as a specimen, to determine the concentration of the cortisol in the body. This would have an importance to verify the response of the hypothalamus-pituitary-adrenocortical axis to the physical activity.","PeriodicalId":189690,"journal":{"name":"Trichology and Cosmetology – Open Journal","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125473444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Absorbable threads represent one of the most exciting breakthroughs in aesthetic medicine. The innovative composition of absorbable poly-L-lactic acid (PLLA)/caprolactone (PCL) threads enriched with hyaluronic acid (HA) has triggered the interest of aesthetic practitioners. Objective To compare the aesthetic outcomes of armouring procedures with absorbable PLLA/PCL threads versus the same procedure performed with PLLA/PCL/HA threads (APTOS, Tbilisi, Georgia threads). Materials and Methods Eight patients underwent thread insertion in the face (PLLA/PCL threads on one side and PLLA/PCL/HA threads on the other). Aesthetic outcome was determined subjectively by the patient after 7 days using a 5-point rating questionnaire. Wrinkles were evaluated objectively using 3D photosystem software after 7, 30, and 90 days. Results Seven days after treatment there was significantly less pain, less swelling, less burning and a faster reduction of skin irregularities on the side treated with HA-enriched threads (all p<0.05). The side of the face treated with HA-enriched threads also demonstrated faster and more obvious improvement of wrinkles. Conclusion Absorbable PLLA/PCL threads have a reliable reputation for oval correction of the face and long-lasting biostimulation. The new HA-enriched threads shorten the post-procedure downtime, accelerate rejuvenation and provide more significant patient satisfaction.
{"title":"Single-Blind Comparative Study of the Aesthetic Outcome of Armouring Procedures with PLLA/PCL- and HA-Enriched Absorbable Threads","authors":"Poleva Irina, Kajaia Albina","doi":"10.17140/tcoj-3-113","DOIUrl":"https://doi.org/10.17140/tcoj-3-113","url":null,"abstract":"Background Absorbable threads represent one of the most exciting breakthroughs in aesthetic medicine. The innovative composition of absorbable poly-L-lactic acid (PLLA)/caprolactone (PCL) threads enriched with hyaluronic acid (HA) has triggered the interest of aesthetic practitioners. Objective To compare the aesthetic outcomes of armouring procedures with absorbable PLLA/PCL threads versus the same procedure performed with PLLA/PCL/HA threads (APTOS, Tbilisi, Georgia threads). Materials and Methods Eight patients underwent thread insertion in the face (PLLA/PCL threads on one side and PLLA/PCL/HA threads on the other). Aesthetic outcome was determined subjectively by the patient after 7 days using a 5-point rating questionnaire. Wrinkles were evaluated objectively using 3D photosystem software after 7, 30, and 90 days. Results Seven days after treatment there was significantly less pain, less swelling, less burning and a faster reduction of skin irregularities on the side treated with HA-enriched threads (all p<0.05). The side of the face treated with HA-enriched threads also demonstrated faster and more obvious improvement of wrinkles. Conclusion Absorbable PLLA/PCL threads have a reliable reputation for oval correction of the face and long-lasting biostimulation. The new HA-enriched threads shorten the post-procedure downtime, accelerate rejuvenation and provide more significant patient satisfaction.","PeriodicalId":189690,"journal":{"name":"Trichology and Cosmetology – Open Journal","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116693736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Laser vaginal rejuvenation is a minimally invasive fractional carbon dioxide (CO2) laser procedure for the woman with vulvovaginal atrophy (VVA), vaginal laxity and for the enhancement of sexual functioning. It has also been proposed for the woman with urge and stress urinary incontinence. CO2 stimulates collagen/elastin contraction, neocollagenesis, and neovascularization. Aim To study the efficacy of CO2 laser in the improvement of VVA, stress urinary incontinence, urge incontinence and sexual functioning. Materials and Methods Twenty-six patients who were in the menopausal transition to post-menopausal age group who presented with any one of the above-mentioned complaints were enrolled in our study. Prior to the treatment, a vaginal examination was performed to ensure patients’ eligibility for the treatment and to determine the vaginal health index score (VHIS), subjective evaluation of VVA symptoms was provided using the visual analog scale (VAS) and the vaginal tightening and patients’ satisfaction were assessed. They also took a questionnaire regarding their sexual functioning. They underwent 3 sessions of CO2 laser with a 1-month interval. Results Significant improvement in VVA was noted after 12-weeks which was observed in vaginal elasticity, fluid volume, epithelial integrity, and patients noted the reduced intensity of vaginal symptoms, such as vaginal burning, dryness, itching, and dyspareunia which was confirmed by improvement in VHIS and VAS. There was a subjective improvement in some patients for stress urinary incontinence (SUI) and user interface (UI) as per patient feedback. Patients also noted a significant improvement in quality of life (QoL) and sexual functioning as there were improvement in female sexual function index (FSFI) and domain scores (i.e., desire, arousal, lubrication, pain, orgasm, satisfaction). Conclusion Fractional CO2 laser treatment definitely improved symptoms associated with VVA, stress and urge urinary incontinence, sexual functioning and overall QoL. Although various parameters and long-term results are yet to be noted, the treatment gives satisfying, non-surgical, out-patient, non-hormonal treatment for vaginal health.
{"title":"Fractional CO2 Laser Treatment for Vaginal Rejuvenation in Post-Menopausal Indian Women","authors":"R. Pillai, S. Rahim","doi":"10.17140/tcoj-3-111","DOIUrl":"https://doi.org/10.17140/tcoj-3-111","url":null,"abstract":"Background Laser vaginal rejuvenation is a minimally invasive fractional carbon dioxide (CO2) laser procedure for the woman with vulvovaginal atrophy (VVA), vaginal laxity and for the enhancement of sexual functioning. It has also been proposed for the woman with urge and stress urinary incontinence. CO2 stimulates collagen/elastin contraction, neocollagenesis, and neovascularization. Aim To study the efficacy of CO2 laser in the improvement of VVA, stress urinary incontinence, urge incontinence and sexual functioning. Materials and Methods Twenty-six patients who were in the menopausal transition to post-menopausal age group who presented with any one of the above-mentioned complaints were enrolled in our study. Prior to the treatment, a vaginal examination was performed to ensure patients’ eligibility for the treatment and to determine the vaginal health index score (VHIS), subjective evaluation of VVA symptoms was provided using the visual analog scale (VAS) and the vaginal tightening and patients’ satisfaction were assessed. They also took a questionnaire regarding their sexual functioning. They underwent 3 sessions of CO2 laser with a 1-month interval. Results Significant improvement in VVA was noted after 12-weeks which was observed in vaginal elasticity, fluid volume, epithelial integrity, and patients noted the reduced intensity of vaginal symptoms, such as vaginal burning, dryness, itching, and dyspareunia which was confirmed by improvement in VHIS and VAS. There was a subjective improvement in some patients for stress urinary incontinence (SUI) and user interface (UI) as per patient feedback. Patients also noted a significant improvement in quality of life (QoL) and sexual functioning as there were improvement in female sexual function index (FSFI) and domain scores (i.e., desire, arousal, lubrication, pain, orgasm, satisfaction). Conclusion Fractional CO2 laser treatment definitely improved symptoms associated with VVA, stress and urge urinary incontinence, sexual functioning and overall QoL. Although various parameters and long-term results are yet to be noted, the treatment gives satisfying, non-surgical, out-patient, non-hormonal treatment for vaginal health.","PeriodicalId":189690,"journal":{"name":"Trichology and Cosmetology – Open Journal","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116683454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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