Pub Date : 2025-12-08DOI: 10.1038/s41569-025-01245-9
Sura Markos
{"title":"Anticoagulation in patients with rheumatic heart disease and atrial fibrillation: implications for low-resource regions.","authors":"Sura Markos","doi":"10.1038/s41569-025-01245-9","DOIUrl":"https://doi.org/10.1038/s41569-025-01245-9","url":null,"abstract":"","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"131 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145704655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.1038/s41569-025-01241-z
Jiandi Liu, Christina Bursill
Liu and Bursill highlight a landmark study that described the presence of in-stent neoatherosclerosis in bare-metal and drug-eluting stents, which has reshaped the clinical management of coronary artery disease.
{"title":"When stents become plaques: in-stent neoatherosclerosis","authors":"Jiandi Liu, Christina Bursill","doi":"10.1038/s41569-025-01241-z","DOIUrl":"10.1038/s41569-025-01241-z","url":null,"abstract":"Liu and Bursill highlight a landmark study that described the presence of in-stent neoatherosclerosis in bare-metal and drug-eluting stents, which has reshaped the clinical management of coronary artery disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 2","pages":"85-85"},"PeriodicalIF":44.2,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145599310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.1038/s41569-025-01237-9
Navin Suthahar
In this Comment, I propose an outcome-oriented classification of heart failure based on skeletal muscle mass. By distinguishing between heart failure with either preserved or reduced muscle mass, this conceptual framework represents a major step towards abandoning the misleading concept of the ‘obesity–mortality paradox’ in cardiology.
{"title":"Redefining heart failure subtypes according to skeletal muscle mass","authors":"Navin Suthahar","doi":"10.1038/s41569-025-01237-9","DOIUrl":"10.1038/s41569-025-01237-9","url":null,"abstract":"In this Comment, I propose an outcome-oriented classification of heart failure based on skeletal muscle mass. By distinguishing between heart failure with either preserved or reduced muscle mass, this conceptual framework represents a major step towards abandoning the misleading concept of the ‘obesity–mortality paradox’ in cardiology.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 2","pages":"79-80"},"PeriodicalIF":44.2,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145599308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.1038/s41569-025-01239-7
Andrea Zambrano
Andrea Zambrano highlights the study that catalysed the field of reverse cardio-oncology by showing that myocardial infarction promotes breast tumour growth in mice.
Andrea Zambrano强调了一项研究，该研究通过表明心肌梗死促进了小鼠乳腺肿瘤的生长，从而促进了反向心脏肿瘤学领域的发展。
{"title":"Linking cardiovascular disease to cancer progression","authors":"Andrea Zambrano","doi":"10.1038/s41569-025-01239-7","DOIUrl":"10.1038/s41569-025-01239-7","url":null,"abstract":"Andrea Zambrano highlights the study that catalysed the field of reverse cardio-oncology by showing that myocardial infarction promotes breast tumour growth in mice.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 2","pages":"83-83"},"PeriodicalIF":44.2,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145599309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.1038/s41569-025-01240-0
Gregory B. Lim
In the VESALIUS-CV trial, the PCSK9 inhibitor evolocumab reduced the risk of a first cardiovascular event in patients with atherosclerosis or diabetes mellitus but without a previous myocardial infarction or stroke.
{"title":"PCSK9 inhibition for primary prevention of cardiovascular events","authors":"Gregory B. Lim","doi":"10.1038/s41569-025-01240-0","DOIUrl":"10.1038/s41569-025-01240-0","url":null,"abstract":"In the VESALIUS-CV trial, the PCSK9 inhibitor evolocumab reduced the risk of a first cardiovascular event in patients with atherosclerosis or diabetes mellitus but without a previous myocardial infarction or stroke.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 1","pages":"6-6"},"PeriodicalIF":44.2,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145599311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1038/s41569-025-01235-x
Robert H. Schneider, Keith C. Norris, Robert D. Brook
Psychosocial stress is a major, modifiable driver of hypertension and cardiovascular disease. Transcendental Meditation can effectively lower blood pressure, improve cardiometabolic health and might even reduce clinical cardiovascular disease events. Recognizing Transcendental Meditation within prevention frameworks could transform stress management from a lifestyle option into a core strategy for cardiovascular protection.
{"title":"Transcendental Meditation to combat psychosocial stress, hypertension and cardiovascular disease","authors":"Robert H. Schneider, Keith C. Norris, Robert D. Brook","doi":"10.1038/s41569-025-01235-x","DOIUrl":"10.1038/s41569-025-01235-x","url":null,"abstract":"Psychosocial stress is a major, modifiable driver of hypertension and cardiovascular disease. Transcendental Meditation can effectively lower blood pressure, improve cardiometabolic health and might even reduce clinical cardiovascular disease events. Recognizing Transcendental Meditation within prevention frameworks could transform stress management from a lifestyle option into a core strategy for cardiovascular protection.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 1","pages":"4-5"},"PeriodicalIF":44.2,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145553743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1038/s41569-025-01236-w
Annelise M. Poss
Annelise Poss discusses the importance of mouse substrain selection in models of cardiovascular research, highlighting a study that demonstrated the influence of mouse substrain genetic diversity on the phenotypic characteristics of the disease model.
{"title":"Mouse substrain is ceNNTral to the cardiac response to transverse aortic constriction","authors":"Annelise M. Poss","doi":"10.1038/s41569-025-01236-w","DOIUrl":"10.1038/s41569-025-01236-w","url":null,"abstract":"Annelise Poss discusses the importance of mouse substrain selection in models of cardiovascular research, highlighting a study that demonstrated the influence of mouse substrain genetic diversity on the phenotypic characteristics of the disease model.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 2","pages":"84-84"},"PeriodicalIF":44.2,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145545427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1038/s41569-025-01231-1
Omar Hahad, Shady Abohashem
The 2021 American Heart Association scientific statement on the ‘mind–heart–body connection’ brought psychological health on to the cardiovascular stage. A new 2025 European Society of Cardiology clinical consensus statement advances this field, translating concepts into operational pathways with screening algorithms, stepped care and pharmacotherapy guidance. Together, these recommendations mark a pivotal shift, moving from why mental health matters in cardiology to how it can be systematically delivered in practice.
{"title":"Integration of cardiovascular and mental health: from concepts to the clinic","authors":"Omar Hahad, Shady Abohashem","doi":"10.1038/s41569-025-01231-1","DOIUrl":"10.1038/s41569-025-01231-1","url":null,"abstract":"The 2021 American Heart Association scientific statement on the ‘mind–heart–body connection’ brought psychological health on to the cardiovascular stage. A new 2025 European Society of Cardiology clinical consensus statement advances this field, translating concepts into operational pathways with screening algorithms, stepped care and pharmacotherapy guidance. Together, these recommendations mark a pivotal shift, moving from why mental health matters in cardiology to how it can be systematically delivered in practice.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 1","pages":"1-3"},"PeriodicalIF":44.2,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-07DOI: 10.1038/s41569-025-01232-0
Shafqat Ahmad, Gull Rukh
Shafqat Ahmad and Gull Rukh discuss a landmark, twin-based, epidemiological study that highlighted how genetic predisposition and environmental factors interact to influence the risk of coronary heart disease.
{"title":"Gene–environment interactions in the pathogenesis of cardiovascular disease","authors":"Shafqat Ahmad, Gull Rukh","doi":"10.1038/s41569-025-01232-0","DOIUrl":"10.1038/s41569-025-01232-0","url":null,"abstract":"Shafqat Ahmad and Gull Rukh discuss a landmark, twin-based, epidemiological study that highlighted how genetic predisposition and environmental factors interact to influence the risk of coronary heart disease.","PeriodicalId":18976,"journal":{"name":"Nature Reviews Cardiology","volume":"23 1","pages":"8-8"},"PeriodicalIF":44.2,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145455422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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