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Formulation Development, Statistical Optimization and Characterization of the Self-Microemulsifying Drug Delivery System (SMEDDS) of Irbesartan 厄贝沙坦自微乳化给药系统(SMEDDS)的配方开发、统计优化及表征
Pub Date : 2019-06-25 DOI: 10.2174/2210681208666180125143258
S. Swain, P. K. Sahu, B. R. Jena, S. Beg, S. M. Babu
Irbesartan is an anti-hypertensive BCS class II drug exhibiting poor aqueoussolubility, which makes it highly challenging for delivery through the oral route. Based on this fact, aself-microemulsifying drug delivery system (SMEDDS) was designed and characterized for augmentingthe aqueous solubility and dissolution rate of irbesartan.Several blends of oil (Capmul MCM EP), surfactant (Tween 80) and co-surfactant (PEG 600)were screened from the preliminary solubility and pseudo-ternary phase diagram studies. Systematic optimizationof the SMEDDS was carried out using 3-factor 3-level Box-Behnken design.The optimized formulation was identified by numerical optimization technique, which revealedfaster emulsification time, high percent transmittance and drug content, lower globule size < 100 nm,zeta potential and excellent thermodynamic stability. The optimal formulation unveiled more than93.3% drug release in vitro within 60 minutes, while the pure drug exhibited only 20% drug release, respectively.Ex vivo permeability and in situ intestinal absorption of drugs was improved nearly 2 to 3-fold by the optimal SMEDDS formulation against the pure drug alone (p < 0.001). Overall, the proposedSMEDDS formulation of irbesartan exhibited a superior biopharmaceutical performance.
厄贝沙坦是一种抗高血压的BCS II类药物,具有较差的水溶性,这使得通过口服途径给药极具挑战性。在此基础上,设计了提高厄贝沙坦溶解度和溶出率的自微乳化给药系统。从初步溶解度和拟三元相图研究中筛选出了几种油(Capmul MCM EP)、表面活性剂(Tween 80)和助表面活性剂(PEG 600)的共混物。采用3因素3水平Box-Behnken设计对SMEDDS进行了系统优化。优化后的配方乳化时间短,透光率高,药物含量高,粒径< 100 nm,zeta电位小,热力学稳定性好。最优处方60分钟体外释药率达93.3%以上,纯药60分钟体外释药率仅为20%。与纯药物相比,最佳SMEDDS配方可使药物的体外通透性和原位肠道吸收提高近2 ~ 3倍(p < 0.001)。总体而言,所提出的厄贝沙坦dsmedds制剂表现出优越的生物制药性能。
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引用次数: 2
Prominent Visible Light Photocatalytic and Water Purification Activity of PbS/CdS/CdO Nanocomposite Synthesized via Simple Co-Precipitation Method 简单共沉淀法合成的PbS/CdS/CdO纳米复合材料的可见光催化和水净化活性
Pub Date : 2019-06-25 DOI: 10.2174/2210681208666180329152523
M. Sabet, M. Mohammadi, Fatemeh Googhari
Due to unique chemical and physical properties and potential application inmany fields, nanostructured materials have attracted many attentions. Cadmium sulfide (CdS) is a semiconductorthat has a wide band gap of 2.42 eV at room temperature and can be served in solar cellsand photoluminescence devices. Cadmium sulfide (CdS) is a kind of attractive semiconductor material,and it is now widely used for optoelectronic applications. CdS nano and microstructures can be synthesizedvia different chemical methods such as microwave-solvothermal synthesis, surfactant-ligand coassistingsolvothermal method and hydrothermal route. Also different morphologies of this semiconductorsuch as dendrites, nanorods, sphere-like, flakes, nanowires, flower-like shape triangular andhexagonal plates, were synthesized.To synthesis of the nanocomposite, a simple co-precipitation method was served. In briefly,0.1 g of Pb(NO3)2 was dissolved in the distilled water (Solution 1). Also different aqueous solutionswere made from dissolving different mole ratio of Cd(NO3)2.6H2O respect to the lead source in thewater (Solution 2). Two solutions were mixed together under vigorous stirring and then S2- solution(0.02 g thiourea in the water) was added to the Pb2+/Cd2+ solution. After that 0.1 g of CTAB assurfactant was added to the final solution. Finally to the synthesis of both sulfide and oxidenanostructures, NaOH solution was added to the prepared solution to obtain pH= 10. Distilled waterand absolute ethanol were used to wash the obtained precipitate and then it dried at 80 °C for 8 h.From the XRD pattern it was found that the peaks placed at 24.9°, 27°, 44.1°, 48°, 52°, 54°,57.8°, 66.8°, 71.2° are associated to CdS compound with hexagonal phase (JCPDS=00-001-0780) thatbelong to (100), (002), (110), (103), (112), (201), (202), (203), (211) Miller indices respectively. TheOther peaks belong to PbS with hexagonal phase (JCPDS=01-078-1897), and CdO with cubic phase(JCPDS=00-001-1049). From SEM images, it was found by choosing the mole ratio to 1:1, very smalland uniform particles were achieved. By increasing Pb2+/Cd2+ mole ratio to 1:2, very tiny particles aggregatedtogether were achieved.The results showed that the product can adsorb extra 80% of heavy metal ions from thewater. So it can be said that the nanocomposite can be used in the water treatment due to its high photocatalyticand surface adsorption activities. In other words, it can remove heavy metals from the waterand also decompose organic pollutions.
纳米结构材料由于其独特的化学和物理性质以及在许多领域的潜在应用,引起了人们的广泛关注。硫化镉(cd)是一种在室温下具有2.42 eV宽禁带隙的半导体材料,可用于太阳能电池和光致发光器件。硫化镉(cd)是一种极具吸引力的半导体材料,目前已广泛应用于光电子领域。采用微波-溶剂热法、表面活性剂-配体助溶法、溶剂热法和水热法等不同的化学方法可以合成CdS的纳米结构和微观结构。此外,还合成了这种半导体的不同形态,如枝晶、纳米棒、球形、薄片、纳米线、花状三角形和六角形板。采用一种简单的共沉淀法合成了纳米复合材料。简单地说,将0.1 g的Pb(NO3)2溶解在蒸馏水(溶液1)中,并将Cd(NO3)2.6H2O相对于铅源(溶液2)的不同摩尔比溶解成不同的水溶液。两种溶液在剧烈搅拌下混合,然后将S2-溶液(水中含有0.02 g硫脲)加入到Pb2+/Cd2+溶液中。在最终溶液中加入0.1 g CTAB保证剂。最后在制备好的溶液中加入NaOH溶液,得到pH= 10,以合成硫化物和氧化结构。用蒸馏水和无水乙醇洗涤所得沉淀物,80℃干燥8 h。XRD谱图表明,在24.9°、27°、44.1°、48°、52°、54°、57.8°、66.8°、71.2°处的峰为六方相CdS化合物(JCPDS=00-001-0780),分别属于米勒指数(100)、(002)、(110)、(103)、(112)、(201)、(202)、(203)、(211)。其他峰属于六方相的PbS (JCPDS=01-078-1897)和立方相的CdO (JCPDS=00-001-1049)。从SEM图像中可以发现,选择摩尔比为1:1时,可以得到非常小而均匀的颗粒。通过将Pb2+/Cd2+的摩尔比增加到1:2,可以得到非常微小的颗粒聚集在一起。结果表明,该产品可额外吸附水中80%的重金属离子。因此,纳米复合材料具有较高的光催化活性和表面吸附活性,可用于水处理。换句话说,它可以去除水中的重金属,也可以分解有机污染物。
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引用次数: 3
Multiple Quantum Barrier Nano-avalanche Photodiodes - Part II: Excess Noise Characteristics 多量子势垒纳米雪崩光电二极管。第二部分:过量噪声特性
Pub Date : 2019-06-25 DOI: 10.2174/2210681208666180813123035
Somrita Ghosh, A. Acharyya
Excess noise characteristics of Multiple Quantum Barrier (MQB) nanoscaleavalanche photodiodes (APDs) based on Si~3C-SiC heterostructures have been studied inthis part of the paper. The multiplication gain and Excess Noise Factor (ENF) of the MQB APDshave been calculated by varying the number of Quantum Barriers (QBs). The numerically calculated ENF values of MQB APDs have been compared with theENF of Si flat conventional APDs of similar dimensions and it is observed that the use of QBs leadsto significant reduction in ENF of the APDs under similar biasing and illumination conditions.Results: The enhanced ratio of hole to electron ionization rates in MQB structures as compared tothe bulk Si APD structure has been found to be the primary cause of improvement in the noise performanceof the MQB nano-APDs.Finally, the numerically calculated ENF of Si flat APD has been compared with the experimentallymeasured ENF of a commercially available Si APD and those are found to be in good agreement;this comparison validates the simulation methodology adopted by the authors in this paper.
本文研究了基于Si~3C-SiC异质结构的多量子势垒(MQB)纳米雪崩光电二极管(apd)的过量噪声特性。通过改变量子势垒(qb)的数量,计算了MQB apds的倍增增益和多余噪声因子(ENF)。数值计算的MQB apd的ENF值与相似尺寸的Si平板apd的ENF进行了比较,发现在相似偏置和照明条件下,qb的使用显著降低了apd的ENF。结果:与体硅APD结构相比,MQB结构中空穴与电子电离率的比值提高是MQB纳米APD噪声性能改善的主要原因。最后,将数值计算的Si平板APD的ENF与市售Si APD的实验测量的ENF进行了比较,发现两者吻合较好,这一对比验证了作者采用的模拟方法。
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引用次数: 2
Multiple Quantum Barrier Nano-avalanche Photodiodes - Part I: Spectral Response 多量子势垒纳米雪崩光电二极管。第一部分:光谱响应
Pub Date : 2019-06-25 DOI: 10.2174/2210681208666180813123550
Somrita Ghosh, A. Acharyya
The spectral response of Multiple Quantum Barrier (MQB) nano-scaleavalanche photodiodes (APDs) based on Si~3C-SiC material system shows considerable responsivityof the device within a very wide wavelength range which includes some portion of Ultra-Violet (UV) spectrum (200- 90 nm), visible spectrum (390-770 nm), near-infrared (700-1400 nm),short-wavelength infrared (1400-3000 nm) and mid-infrared (3000-4000 nm) wavelengths. It hasalready been concluded from preceding studies that Si~3C-SiC MQB APDs shows better spectralresponse and excess noise characteristics as compared to equivalent conventional APDs based onSi. Moreover, the superiority of the illumination through p+-side (ITPS) structure has been observedamong two probable optical illumination configurations such as illumination through n+-side (ITNS) and illumination through p+-side (ITPS) structures.In this paper, the time and frequency responses of Si~3C-SiC MQB APDs have been investigated.A very narrow rectangular pulse of pulse-width of 0.4 ps has been used as the input opticalpulse having 850 nm wavelength incident on the p+-side of the MQB APD structures (i.e. ITPSis considered here) and corresponding current responses have been calculated by using a rigoroussimulation method developed by the authors; finally the frequency responses of the devices are obtainedvia the Fourier transform of the corresponding pulse current responses in time domain.The width of the current responses are limited to 4.7 and 3.1 ps in Si nano-APD andSi~3C-SiC MQB (consisting of five quantum barriers) nano-APD respectively for the input opticalpulse of width 0.4 ps of 850 nm wavelength. On the other hand, the 3 dB upper cut-off frequenciesof the above-mentioned diodes are obtained to be 68.63 and 82.64 GHz respectively.Simulation results show that MQB nano-APDs possess significantly faster time responseand wider frequency response as compared to the flat Si nano-APDs under similar operatingconditions.
基于Si~3C-SiC材料体系的多量子势垒(MQB)纳米雪崩光电二极管(apd)的光谱响应表明,该器件在非常宽的波长范围内具有相当高的响应性,包括紫外线(UV)光谱(200 ~ 90nm)、可见光谱(390 ~ 770 nm)、近红外(700 ~ 1400 nm)、短波红外(1400 ~ 3000 nm)和中红外(3000 ~ 4000 nm)波长的一部分。从以往的研究中已经得出结论,Si~3C-SiC MQB apd与基于Si的等效传统apd相比,具有更好的光谱响应和多余噪声特性。此外,在n+侧(ITNS)和p+侧(ITPS)两种可能的光学照明结构中,观察到p+侧(ITPS)结构的照明优势。本文研究了Si~3C-SiC MQB apd的时间和频率响应。采用脉冲宽度为0.4 ps的极窄矩形脉冲作为850 nm波长的输入光脉冲,入射到MQB APD结构(即本文所考虑的itpsi)的p+侧,并使用作者开发的严格模拟方法计算了相应的电流响应;最后通过脉冲电流响应在时域的傅里叶变换得到器件的频率响应。在850 nm波长、宽度为0.4 ps的输入光脉冲下,Si纳米apd和Si~3C-SiC MQB(由5个量子势垒组成)纳米apd的电流响应宽度分别限制在4.7和3.1 ps。另一方面,上述二极管的3db上限截止频率分别为68.63和82.64 GHz。仿真结果表明,在相同的工作条件下,MQB纳米apd比扁平Si纳米apd具有更快的时间响应和更宽的频率响应。
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引用次数: 3
Using Low Temperature, Cost-effective and Green Methods to Carbon Nanohorn Synthesis 低温、低成本、绿色的碳纳米角合成方法
Pub Date : 2019-06-25 DOI: 10.2174/2210681208666180321143945
A. Hasani
Laser ablation method has high-yield and pure SWCNHs. On the other hand,arc discharge methods have low-cost production of SWCNHs. However, these techniques have moredesirable features, they need special expertness to use high power laser or high current discharge thateither of them produces very high temperature. As for the researches, the temperatures of these techniquesare higher than 4727°C to vaporize the graphite. So, to become aware of the advantages ofSWCNHs, it is necessary to find a new way to synthesize SWCNHs at a lower temperature. In otherwords, reaction field can be expandable at a moderate temperature. This paper reports a new way tosynthesize SWCNHs at an extremely reduced temperature. According to this study, the role of N2 is the protection of the copper holder supporting thegraphite rod by increasing heat transfer from the holder. After the current of 70 A was supplied to thesystem, the temperature of graphite rod was raised to 1600°C. It is obvious that this temperature issomehow higher than the melting point of palladium, 1555°C, and much lower than graphite meltingpoint, 3497°C.Based on the results, there are transitional precursors simultaneous with the SWCNHs. Thiscomposition can be created by distortion of the primary SWCNTs at the higher temperature. Subsequently,each SWCNTs have a tendency to be broken into individual horns. With increasing the concentrationof the free horns, bud-like SWCNHs can be produced. Moreover, there are individual horns almostseparated from the mass of single wall carbon nanohorns. This structure is not common inSWCNHs synthesized by the usual method such as arc discharge or laser ablation. Through these regulartechniques, SWCNHs are synthesized as cumulative particles with diameters about 30-150 nm.A simple heating is needed for SWCNTs transformation to SWCNHs with the presence ofpalladium as catalyst. The well-thought-out mechanism for this transformation is that SWCNTs wereinitially changed to highly curled shape, and after that were formed into small independent horns. Theother rout to synthesize SWCNHs is the pyrolysis of palm olein at 950°C with the assistance of zinc nitrateand ferrocene. Palm olein was used as a promising, bio-renewable and inexpensive carbon sourcefor the production of carbon nanohorns.
激光烧蚀法具有收率高、纯度高的特点。另一方面,电弧放电法生产swcnh成本低。然而,这些技术有更令人满意的特点,它们需要特殊的专业知识来使用高功率激光或大电流放电,两者都可以产生非常高的温度。在本研究中,这些技术的蒸发温度都高于4727℃。因此,为了充分认识到swcnh的优势,有必要寻找一种在较低温度下合成swcnh的新方法。换句话说,反应场在中等温度下是可膨胀的。本文报道了一种在极低温度下合成swcnh的新方法。根据这项研究,N2的作用是通过增加铜支架的传热来保护支撑石墨棒的铜支架。向系统输入70a的电流后,石墨棒的温度升高到1600℃。很明显,这个温度在某种程度上高于钯的熔点1555℃,而远低于石墨的熔点3497℃。结果表明,与swcnh同时存在过渡性前体。这种组合物可以通过在较高温度下对原始SWCNTs进行扭曲而产生。随后,每个SWCNTs都有被分解成单个角的趋势。随着游离角浓度的增加,可以产生芽状的swcnh。此外,单个的碳纳米角几乎与大量的单壁碳纳米角分离。这种结构在电弧放电或激光烧蚀等常用方法合成的swcnh中并不常见。通过这些规则的技术,swcnh被合成为直径约为30-150纳米的累积颗粒。在钯作为催化剂的情况下,将SWCNTs转化为swcnh需要简单的加热。这种转变经过深思熟虑的机制是,SWCNTs最初变成高度卷曲的形状,然后形成独立的小角。另一种合成swcnh的方法是在950℃下,在硝酸锌和二茂铁的辅助下,对棕榈油进行热解。棕榈油是一种具有生物可再生和廉价的碳源,可用于生产碳纳米角。
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引用次数: 2
Thermally Activated Magnetic Switching Mode for Various Thicknesses of Perpendicularly Ferromagnetic Nano-dot 不同厚度垂直铁磁纳米点的热激活磁开关模式
Pub Date : 2019-06-25 DOI: 10.2174/2210681208666180507101809
N. A. Wibowo, Cahya Handoyo, L. R. Sasongko
Even applying thermal pulse has been succeeded to reduce the coercivity throughrandomization the magnetization in such a way stimulate the magnetic reversion, the efficiency of magneticswitching field consumption in writing process still turns out to be an exciting research field to implementthe HAMR technology. One of the remarkable geometric properties of HAMR storage media that can becorrelated to the writing field reduction issue is the nano-dot thickness. Furthermore, thermal fluctuationcauses the magnetization switching process to be probabilistic. This magnetic switching probability determinesthe magnitude of the writing field. This paper aims to investigate the impact of changes in mediathickness on the magnetization process in particular at high temperatures numerically.Nano-dot was modeled as a parallelepiped with uniaxial anisotropy which was regarded as amagnetically isolated system where no disturbance field of neighboring nano-dots. Simulation arrangementswere implemented to evaluate the two viewpoints in the current heat-assisted magnetic recording,either coercivity, as well as writing field consume. Coercivity was gauged by inducing a magnetic fieldwhich linearly increased up to 2 Tesla for 2.5 ns at thermal equilibrium to the surrounding. In evaluatingwriting field consume, thermal field pulse which just below the Curie temperature was generated while themagnetic field inducing the nano-dot. These schemes investigations were based on the Landau-Lifshift-Gilbert equation which accommodates the fluctuation-dissipation theorem in calculating thermal fluctuationeffect. Also, temperature dependent material parameters such as magnetic saturation, magnetic anisotropy,and exchange interaction, were taken into account.At room temperature, the coercive and nucleation fields are highly sensitive to the nano-dot thickness.Under thermal assistance, the writing field for 10 nm and 100 nm of the chosen thicknesses are 0.110T and 0.125 T respectively. These writing grades are significantly lower than the coercivity of the media.For both thicknesses, zero field magnetization reversal phenomena are observed as indicated by the existencesof the switching probabilities at H = 0.This numerical study showed that using the heating assistance close to the Curie point, nanodotswith the chosen thicknesses and magnetic parameters were probably to be magnetized even no drivenmagnetic field. Along with this result, magnetic field induction which required to utterly magnetizing wasonly in the sub-Tesla - about a tenth of the coercive field. During magnetization processes under thermalassistance, randomization of magnetic moments initiated the switching dynamic before the domain wallwas nucleated and propagated to reach a single magnetized domain.
即使已经成功地应用热脉冲通过随机化磁化来降低矫顽力,以这种方式刺激磁反转,但在书写过程中磁开关场消耗的效率仍然是实现HAMR技术的一个令人兴奋的研究领域。HAMR存储介质的一个显著的几何特性是纳米点的厚度,这可能与写入场缩小问题有关。此外,热波动导致磁化转换过程具有概率性。这种磁开关概率决定了写入场的大小。本文旨在用数值方法研究介质厚度变化对磁化过程的影响,特别是在高温下。将纳米点建模为具有单轴各向异性的平行六面体,将其视为不存在相邻纳米点扰动场的磁隔离系统。采用仿真方法对当前热辅助磁记录中的矫顽力和写入场消耗两种观点进行了评价。矫顽力是通过在热平衡状态下向周围诱导一个线性增加到2特斯拉的2.5 ns的磁场来测量的。在计算写入场消耗时,磁场诱导纳米点时产生略低于居里温度的热场脉冲。这些方案的研究基于Landau-Lifshift-Gilbert方程,该方程在计算热波动效应时符合涨落-耗散定理。此外,还考虑了与温度相关的材料参数,如磁饱和度、磁各向异性和交换相互作用。在室温下,矫顽力场和成核场对纳米点厚度高度敏感。在热辅助下,所选厚度在10 nm和100 nm处的写入场分别为0.110T和0.125 T。这些写作成绩明显低于媒体的强制性。对于两种厚度,都观察到零场磁化反转现象,这是由H = 0时开关概率的存在所表明的。数值研究表明,在居里点附近的加热辅助下,即使在没有驱动磁场的情况下,具有选定厚度和磁性参数的纳米点也可能被磁化。伴随着这个结果,需要完全磁化的磁场感应仅在亚特斯拉-大约是矫顽力场的十分之一。在热辅助磁化过程中,磁矩的随机化在畴壁成核并传播到单个磁化畴之前启动了开关动态。
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引用次数: 4
Fabrication and Radiation Dose Properties of Well-dispersed Calcium Borate Nanoparticles 分散良好的硼酸钙纳米颗粒的制备及其辐射剂量特性
Pub Date : 2019-06-25 DOI: 10.2174/2210681207666171107142451
M. E. Haghiri, N. Soltani, E. Saion, A. Izanloo, G. Bahmanrokh, M. Askari
Development of novel materials represents a new and fast evolving application of research in physics and medicine. The area of nanomaterial research has presented interesting physical and chemical properties that cannot be obtained from their macroscopic counterparts.This study has attempted to attain well-dispersed nanoparticles by variation of polymer concentration.In order to obtain the calcium borate nanoparticles, polyvinyl pyrrolidone has been used as a capping agent and the preparation method was performed via simple co-precipitation technique followed by heating treatment. In absence of polymer, the heating process causes un-controlled growth of particles with more flocculation and the nanoplate-shaped particles with mean size of 16.0 ×30.0 nm was formed. The introduction of polymer concentration of 1 wt% was conducted to the formation of spherical shaped nanoparticles with sufficiently narrow size distribution and small average size of 5.5 nm and 13.0 nm for the initial precipitation and heating process, respectively. Moreover, the synthesized calcium borate nanoparticles showed good luminescence properties with a simple glow curve dominating at 150°C.This curve was utilized to derive trapping parameters including the activation energy, order of kinetic and frequency factor.The well-dispersed calcium borate nanoparticles have been prepared successfully by introduction of sufficient concentration of polymer.
新材料的开发代表了物理和医学研究的一个新的和快速发展的应用。纳米材料的研究领域呈现出令人感兴趣的物理和化学性质,而这些性质是无法从宏观材料中获得的。本研究试图通过改变聚合物浓度来获得分散良好的纳米颗粒。以聚乙烯醇吡咯烷酮为封盖剂,采用简单共沉淀法和加热法制备硼酸钙纳米颗粒。在没有聚合物的情况下,加热过程导致颗粒不受控制的生长,絮凝性更强,形成了平均粒径为16.0 ×30.0 nm的纳米板状颗粒。在初始沉淀和加热过程中,引入1 wt%的聚合物,形成粒径分布足够窄的球形纳米颗粒,平均粒径分别为5.5 nm和13.0 nm。此外,合成的硼酸钙纳米颗粒在150℃时表现出良好的发光性能,发光曲线简单。利用该曲线推导出了包括活化能、动力学阶数和频率因子在内的俘获参数。通过引入足够浓度的聚合物,成功制备了分散良好的硼酸钙纳米颗粒。
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引用次数: 0
An Analytical Drain Current Model for Dual-material Gate Graded - channel and Dual-oxide Thickness Cylindrical Gate (DMG-GC-DOT) MOSFET 双材料栅极梯度沟道和双氧化厚度圆柱栅极(DMG-GC-DOT) MOSFET漏极电流解析模型
Pub Date : 2019-06-25 DOI: 10.2174/2210681208666180813122145
Hind Jaafar, A. Aouaj, A. Bouziane, B. Iñíguez
A novel Dual Material Gate Graded Channel and Dual Oxide Thickness CylindricalGate (DMG-GC-DOT) MOSFET is presented in this paper.Analytical model of drain current is developed using a quasi-two-dimensional cylindricalform of the Poisson equation and is expressed as a function of the surface potential, which is calculatedusing the expressions of the current density.Comparison of the analytical results with 3D numerical simulations using Silvaco Atlas -TCAD software presents a good agreement from subthreshold to strong inversion regime and for differentbias voltages.Two oxide thicknesses with different permittivity can effectively improve the subthresholdcurrent of DMG-GC-DOT MOSFET.
提出了一种新型的双材料栅极梯度沟道和双氧化层厚度圆柱状栅极(DMG-GC-DOT) MOSFET。漏极电流的解析模型采用准二维泊松方程的圆柱形式,并以表面电位的函数表示,表面电位的计算采用电流密度表达式。分析结果与利用Silvaco Atlas -TCAD软件进行的三维数值模拟结果比较表明,从亚阈值到强反演区以及不同的偏置电压,分析结果具有较好的一致性。两种不同介电常数的氧化物厚度可以有效地提高DMG-GC-DOT MOSFET的亚阈值电流。
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引用次数: 0
Source Analysis of Nitrate Nitrogen in Groundwater Based on Different Modes of Land use 基于不同土地利用方式的地下水硝态氮来源分析
Pub Date : 2019-06-25 DOI: 10.2174/2210681208666180403113546
L. Zejun, W. Yan, Liang Qiyang, J. Xia, Jian Li, Yong Huang
The study area is located in the Hebei province Luanxian section along theLuanhe River. The right of Luanhe River is arranged with 3 monitoring sections and is laid with 5wells in the A-A section and B-B section and 1 well on the floodplain (inside the dike), the distancefrom the river level is about 10m. The distance between the 4 wells outside the dike is 20m, 50m,200m and 1500m respectively. 2 wells are arranged on the C-C section, so there are 13 observationwells in the study area. 3# wells and 11# wells have used existing monitoring wells, so 11 wells havebeen set up actually. The monitoring wells are designed to monitor groundwater level, groundwaterquality and isotope analysis.In the upstream of Luanhe’s A-A section of the No. 4 well near the edge of the woods anddownstream of the B-B section of the No. 8 well near the edge of farmland (wheat), each point of soilis sampled to determine the content of nitrate nitrogen and 15N isotope ratio in soil profile. The depthof soil is sampled from surface to groundwater level, the total depth is about 2.5m. Taking about 1kgsoil samples at 20cm every time from the ground surface and collect and seal in plastic bags and number.The sampling time was November 2015, March 2016, May 2016 and July 2016, taking 4 times.The analysis showed that higher nitrate content in soil is within 0-60cm, and is same as thedepth of fertilizing the crops (including animal manure), so when estimating the proportion ofgroundwater in nitrate, nitrate content in 0-60cm is assumed as the initial value; which is close to theunderground water level in the soil and is regarded as the final value of 60cm, that is, the final value ofnitrate into the groundwater, which can estimate the soil nitrate into groundwater ratio. The sources of nitrate in groundwater are complex and related to many factors, such asriver water, soil and so on. According to the content of nitrogen and oxygen isotopes, it determines themain source of nitrate nitrogen:soil and Luanhe River. The results showed that the ratio of nitrate togroundwater in the forest soil was 20%~80.8%, and the average value was 56.3%. The proportion ofnitrate in the soil in the wheat field was 6.8%~98.2%, with an average value of 48.3%. Nitrate nitrogenfrom water in proportion of large changes with the seasons, the upper reaches of the Luanhe River(near No. 2 wells) for 0~19.6%; the Luanhe River (near No. 7 wells) for 0~31.5%.
研究区位于河北省滦河沿岸滦县段。滦河右侧设置3个监测断面,a、b、b段各设5口井,河漫滩上(堤内)设1口井,距河面约10m。堤外4口井之间的距离分别为20m、50m、200m、1500m。C-C段布置2口井,研究区共有13口观测井。3口井和11口井利用现有监测井,实际建井11口。监测井设计用于监测地下水位、地下水水质和同位素分析。在滦河4号井A-A段上游靠近树林边缘,8号井B-B段下游靠近农田(小麦)边缘,对各点土壤进行取样,测定土壤剖面中硝态氮含量和15N同位素比值。土壤取样深度从地表至地下,总深度约2.5m。每次距地表20cm处取1公斤左右的土壤样本,收集后用塑料袋密封,并编号。采样时间为2015年11月、2016年3月、2016年5月、2016年7月,共4次。分析表明,0-60cm土壤中硝酸盐含量较高,且与作物施肥深度(含畜禽粪便)相同,因此在估算地下水中硝酸盐含量比例时,假设0-60cm土壤中硝酸盐含量为初始值;其中接近土壤中的地下水位,作为60cm的终值,即硝酸盐进入地下水的终值,可以估算出土壤中硝酸盐进入地下水的比例。地下水中硝酸盐的来源复杂,与河流、土壤等因素有关。根据氮、氧同位素含量,确定了硝态氮的主要来源:土壤和滦河。结果表明,森林土壤中硝酸盐与地下水的比值为20%~80.8%,平均值为56.3%。麦田土壤中硝酸盐含量为6.8%~98.2%,平均值为48.3%。水体中硝态氮占比随季节变化较大,滦河上游(2号井附近)为0~19.6%;滦河(7号井附近)为0~31.5%。
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引用次数: 0
Solid Lipid Nanoparticles: A Potential Approach for Drug Delivery System 固体脂质纳米颗粒:一种潜在的药物输送系统
Pub Date : 2019-05-31 DOI: 10.2174/2210681208666180321144536
Babita Sarangi, U. Jana, N. Palei, Guru Prasad, P. K. Manna
The therapeutic efficacy of perorally administered drug is often concealed by their poor oralbioavailability (BA) and low metabolic stability in the gastrointestinal tract (GIT). Most of the newlydiscovered drug molecules are of high molecular weight and belong to biopharmaceutical classificationsystem (BCS) – II. Poor aqueous solubility and high membrane permeability characteristics of BCS –II drugs limit BA after oral administration. Recently, lipid-based drug delivery (LBDD) systems havegained much importance due to their ability to improve the solubility and BA of poorly soluble drugs.Oral delivery of drugs incorporated in solid lipid nanoparticles (SLNs) has gained considerable interestsince the last two decades. SLNs have advantages above the others, as compared to polymer toxicitywhich is low, as inexpensive excipients and organic solvents are not used. SLNs offer the possibility todevelop new therapeutics due to their unique size-dependent properties. An attempt to incorporatedrugs into SLNs offers a new prototype in drug delivery system which can be utilized for drug targetingto specific tissue. This review presents elaborate information of SLNs with their aim, advantages,challenges and limitations, the principle of formulation, routes of administration and their biodistribution.It also describes the gastrointestinal absorption and the factors affecting absorption of SLNs fromGIT along with its application.
口服给药的疗效往往被其较差的口服生物利用度(BA)和较低的胃肠道代谢稳定性(GIT)所掩盖。新发现的药物分子多为高分子量分子,属于生物制药分类系统(BCS) - II。BCS -II类药物水溶性差、膜透性高的特点限制了口服给药后的BA。近年来,脂基给药系统(LBDD)因其改善难溶性药物的溶解度和BA的能力而受到越来越多的重视。近二十年来,口服脂质纳米颗粒(sln)药物获得了相当大的兴趣。与低毒性的聚合物相比,sln具有优势,因为它不使用廉价的赋形剂和有机溶剂。sln由于其独特的尺寸依赖性,为开发新的治疗方法提供了可能性。将药物掺入sln的尝试为药物靶向到特定组织提供了一种新的药物传递系统原型。本文综述了sln的目的、优势、挑战和局限性、配方原理、给药途径和生物分布等方面的详细信息。介绍了胃肠道吸收、影响胃肠道吸收的因素及其在胃肠道中的应用。
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引用次数: 6
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Nanoscience & Nanotechnology-Asia
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