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Benefits of Using the CRISPR/Cas9 System for the Correction of Genetic Mutations 使用 CRISPR/Cas9 系统纠正基因突变的好处
IF 0.5 4区 生物学 Q4 Medicine
Molecular Genetics, Microbiology and Virology
Pub Date : 2023-09-01 DOI: 10.3103/s0891416823030084

Abstract

The discovery of the CRISPR/Cas9 gene scissors technology was a breakthrough in the development of gene therapy methods and attracted the attention of the entire scientific community. This technology provides prospects for the treatment of many neurodegenerative diseases and cancers that were previously considered almost incurable. To date, the mechanisms of the development and progression of these groups of nosologies are becoming increasingly studied due to discoveries in the field of molecular biology and genetics. However, the application of the CRISPR/Cas9 technology has some limitations and difficulties that should be considered. The development of works on the creation and selection of specific gene carriers, a thorough safety assessment of modern genetic manipulations, and the integrated participation of specialists from different fields of science will be important to solve the problems associated with the use of the CRISPR/Cas9 technology and achieve the desired therapeutic effect.

摘要 CRISPR/Cas9 基因剪刀技术的发现是基因治疗方法发展的一个突破，吸引了整个科学界的关注。这项技术为治疗许多以前被认为几乎无法治愈的神经退行性疾病和癌症提供了前景。迄今为止，由于分子生物学和遗传学领域的发现，对这几类疾病的发生和发展机制的研究日益深入。然而，CRISPR/Cas9 技术的应用也有一些局限性和困难需要考虑。要解决与使用 CRISPR/Cas9 技术相关的问题并达到预期的治疗效果，就必须开展关于创建和选择特定基因载体的工作，对现代基因操作进行全面的安全评估，以及不同科学领域专家的共同参与。
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引用次数: 0
Hantaviruses in Populations of Voles in Siberia 西伯利亚田鼠种群中的汉坦病毒
4区 生物学 Q4 Medicine
Molecular Genetics, Microbiology and Virology
Pub Date : 2023-06-01 DOI: 10.3103/s0891416823020106
L. N. Yashina, S. A. Abramov, N. A. Smetannikova, B. S. Malyshev, T. A. Dupal, A. V. Krivopalov
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引用次数: 0
Lactobacillus crispatus and Human Herpes Simplex Virus-2, an In Vitro Study crispr乳杆菌与人类单纯疱疹病毒2的体外研究
4区 生物学 Q4 Medicine
Molecular Genetics, Microbiology and Virology
Pub Date : 2023-06-01 DOI: 10.3103/s0891416823020040
Mehdi Moazzami Goudarzi, Mohammad Reza Fazeli, Abbas Akhavan Sepahi, Akram Eidi
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引用次数: 0
Recombinant RBD of the SARS-CoV-2 Spike Protein: Production in Escherichia coli Cells, Binding to Antibodies, and Antiviral Activity SARS-CoV-2刺突蛋白的重组RBD:在大肠杆菌细胞中的产生、与抗体的结合和抗病毒活性
4区 生物学 Q4 Medicine
Molecular Genetics, Microbiology and Virology
Pub Date : 2023-06-01 DOI: 10.3103/s0891416823020052
M. S. Gromova, A. V. Gromov, T. M. Grunina, A. M. Lyashchuk, Z. M. Galushkina, M. E. Subbotina, I. B. Esmagambetov, E. I. Ryabova, V. V. Prokofiev, A. V. Kovyrshina, A. A. Ilyukhina, A. Y. Shelkov, A. S. Karyagina, V. G. Lunin
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引用次数: 0
Composition of Populations and Durations of Persistence of Bordetella pertussis Bacteria in Patients with Whooping Cough and Contact Persons 百日咳患者及接触者百日咳杆菌的种群组成及持续时间
4区 生物学 Q4 Medicine
Molecular Genetics, Microbiology and Virology
Pub Date : 2023-06-01 DOI: 10.3103/s0891416823020064
A. Yu. Medkova, E. G. Semin, S. V. Kulikov, Yu. V. Nesterova, I. V. Babachenko, L. N. Sinyashina, G. I. Karataev
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引用次数: 0
Monoclonal Antibody Panel for Hepatitis B Virus Genotype and HBsAg Subtype Identification: Results Obtained for Blood-Serum Samples from Three Regions of Russia 乙型肝炎病毒基因型和乙型肝炎表面抗原亚型鉴定的单克隆抗体小组:从俄罗斯三个地区获得的血清样本的结果
4区 生物学 Q4 Medicine
Molecular Genetics, Microbiology and Virology
Pub Date : 2023-06-01 DOI: 10.3103/s0891416823020039
L. V. Bezuglova, E. I. Sergeeva, L. Yu. Voevodskaya, E. E. Lysykh, N. V. Polovitsa, I. V. Deliy, M. K. Ivanov, I. G. Netesova, S. V. Netesov
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引用次数: 0
RNA N6-Methyladenosine Pathway Writer Genes Expression Levels and Clinical Severity of Infection in Covid-19 Patients RNA n6 -甲基腺苷途径Writer基因表达水平与新冠肺炎患者感染的临床严重程度
4区 生物学 Q4 Medicine
Molecular Genetics, Microbiology and Virology
Pub Date : 2023-06-01 DOI: 10.3103/s0891416823020118
Badel Arslan, Sevgi Baltacı, Burcu Bayyurt, Nil Özbilum Sahin, Murat Eser Akyurek, Mehmet Bakır, Serdal Arslan
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引用次数: 0
Association of Mutations in gyrA Gene with Resistance to Fluoroquinolones in Clinical Isolates of Multidrug-Resistant Mycobacterium tuberculosis 耐多药结核分枝杆菌临床分离株gyrA基因突变与氟喹诺酮类药物耐药性的关系
4区 生物学 Q4 Medicine
Molecular Genetics, Microbiology and Virology
Pub Date : 2023-06-01 DOI: 10.3103/s0891416823020027
Hanieh Bagherifard, Mitra Salehi, Mona Ghazi
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引用次数: 0
LZTFL1 rs17713054 Polymorphism as an Indicator Allele for COVID-19 Severity LZTFL1 rs17713054多态性作为COVID-19严重程度的指示等位基因
4区 生物学 Q4 Medicine
Molecular Genetics, Microbiology and Virology
Pub Date : 2023-06-01 DOI: 10.3103/s0891416823020088
Mona Roozbehani, Hossein Keyvani, MohammadHossein Razizadeh, Parastoo Yousefi, Ali Gholami, Alireza Tabibzadeh, Leila Mousavizadeh
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引用次数: 0
Pogo DNA Transposons in the Genomes of the Aurelia Genus Jellyfish 水母属基因组中的Pogo DNA转座子
4区 生物学 Q4 Medicine
Molecular Genetics, Microbiology and Virology
Pub Date : 2023-06-01 DOI: 10.3103/s089141682302009x
Y. N. Ulupova, M. V. Puzakov, L. V. Puzakova
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引用次数: 0
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