The key clinical feature of hemiplegic migraine (HM) is motor aura symptomatology. The diagnosis is confirmed by the finding of autosomal dominantly
偏瘫性偏头痛的主要临床特征是运动先兆症状。常染色体显性的发现证实了诊断
{"title":"A Different Kind of Hemiplegic Migraine Gene","authors":"N. Pelzer","doi":"10.1056/NEJM-JW.NA54235","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54235","url":null,"abstract":"The key clinical feature of hemiplegic migraine (HM) is motor aura symptomatology. The diagnosis is confirmed by the finding of autosomal dominantly","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85668101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Allogeneic stem cell transplantation (AlloSCT) with hematopoietic stem cells derived from donor peripheral blood (PB) or bone marrow is a curative
同种异体干细胞移植(AlloSCT)与来自供体外周血(PB)或骨髓的造血干细胞是一种治疗方法
{"title":"Long-Term Outcomes After Allogeneic Stem Cell Transplantation","authors":"Michael E. Williams","doi":"10.1056/NEJM-JW.NA54231","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54231","url":null,"abstract":"Allogeneic stem cell transplantation (AlloSCT) with hematopoietic stem cells derived from donor peripheral blood (PB) or bone marrow is a curative","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82631682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Three randomized trials have shown no difference in outcomes between antibiotic treatment and no antibiotic treatment for patients with mild acute
三项随机试验显示，轻度急性患者接受抗生素治疗和不接受抗生素治疗的结果没有差异
{"title":"Are Antibiotics Required for Mild Acute Diverticulitis","authors":"A. Brett","doi":"10.1056/NEJM-JW.NA54248","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54248","url":null,"abstract":"Three randomized trials have shown no difference in outcomes between antibiotic treatment and no antibiotic treatment for patients with mild acute","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78129995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patients' responses to drug therapies for painful knee and hip osteoarthritis (OA) are unpredictable and often disappointing. In this network
患者对疼痛的膝关节和髋关节骨关节炎(OA)的药物治疗的反应是不可预测的，往往令人失望。在这个网络中
{"title":"Drug Treatment of Painful Knee and Hip Osteoarthritis: A Meta-Analysis","authors":"A. Brett","doi":"10.1056/NEJM-JW.NA54207","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54207","url":null,"abstract":"Patients' responses to drug therapies for painful knee and hip osteoarthritis (OA) are unpredictable and often disappointing. In this network","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":"239 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76902042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Small Guillain-Barré Risk from Recombinant Zoster Vaccine","authors":"A. Zuger","doi":"10.1056/NEJM-JW.NA54256","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54256","url":null,"abstract":"The association between Guillain-Barre syndrome (GBS) and common vaccines inspires ongoing debate (Clin Infect Dis 2019; 69:726). A small excess risk","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91533302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The diets of many older adults provide insufficient calcium and protein to maintain bone and muscle mass, which likely raises risk for falls and
许多老年人的饮食不能提供足够的钙和蛋白质来维持骨骼和肌肉质量，这可能会增加跌倒和受伤的风险
{"title":"Adding Dietary Calcium and Protein Might Prevent Falls and Fractures in Older Adults","authors":"B. Soloway","doi":"10.1056/NEJM-JW.NA54217","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54217","url":null,"abstract":"The diets of many older adults provide insufficient calcium and protein to maintain bone and muscle mass, which likely raises risk for falls and","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89149204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recognition that the inpatient environment is often contaminated with multidrug-resistant organisms (MDROs) has led hospitals to pursue enhanced
认识到住院环境经常受到耐多药生物(mdro)的污染，导致医院寻求加强
{"title":"Still in the Dark: How Well Does UV-C Light Disinfection Work?","authors":"R. Ellison","doi":"10.1056/NEJM-JW.NA54211","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54211","url":null,"abstract":"Recognition that the inpatient environment is often contaminated with multidrug-resistant organisms (MDROs) has led hospitals to pursue enhanced","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88091907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prosthetic joint infection (PJI), a severe complication of joint replacement surgery, is most commonly caused by Staphylococcus epidermidis or other
假体关节感染(PJI)是关节置换术的严重并发症，最常由表皮葡萄球菌或其他细菌引起
{"title":"Prosthetic Joint Infections — More Microbiologically Diverse Than Previously Thought?","authors":"T. Glück","doi":"10.1056/NEJM-JW.NA54225","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54225","url":null,"abstract":"Prosthetic joint infection (PJI), a severe complication of joint replacement surgery, is most commonly caused by Staphylococcus epidermidis or other","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91197635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fish oil (marine omega-3 fatty acid) has been shown to decrease adverse cardiovascular events in numerous large-scale randomized, controlled trials
鱼油(海洋omega-3脂肪酸)在许多大规模随机对照试验中已被证明可以减少不良心血管事件
{"title":"Fish Oil Is Associated with Increased Risk for Atrial Fibrillation","authors":"M. Link","doi":"10.1056/NEJM-JW.NA54191","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54191","url":null,"abstract":"Fish oil (marine omega-3 fatty acid) has been shown to decrease adverse cardiovascular events in numerous large-scale randomized, controlled trials","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82965660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Direct oral anticoagulants (DOACs) have replaced warfarin as the anticoagulant of choice in most clinical situations. However, warfarin has remained as
在大多数临床情况下，直接口服抗凝剂(DOACs)已取代华法林成为首选的抗凝剂。然而，华法林仍然是
{"title":"Apixaban vs. Warfarin in Patients with Thrombotic Antiphospholipid Antibody Syndrome","authors":"B. Stein, Mhs","doi":"10.1056/NEJM-JW.NA54241","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54241","url":null,"abstract":"Direct oral anticoagulants (DOACs) have replaced warfarin as the anticoagulant of choice in most clinical situations. However, warfarin has remained as","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82663859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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