Harms related to medications occur commonly. However, the frequency of emergency department (ED) visits and types of medications that lead to harm have
与药物有关的危害经常发生。然而，急诊科(ED)就诊的频率和导致伤害的药物类型有很大的不同
{"title":"Medication Harms Leading to Emergency Department Visits","authors":"D. Dressler, Mhm, Facp.","doi":"10.1056/NEJM-JW.NA54263","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54263","url":null,"abstract":"Harms related to medications occur commonly. However, the frequency of emergency department (ED) visits and types of medications that lead to harm have","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91520158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Despite changing recommendations, aspirin is widely used for both primary and secondary prevention of vascular events such as myocardial infarction and
尽管不断改变建议，阿司匹林被广泛用于一级和二级预防血管事件，如心肌梗死和心绞痛
{"title":"Does Aspirin Use Before Stroke Improve Functional Outcome","authors":"S. Chaturvedi","doi":"10.1056/NEJM-JW.NA54249","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54249","url":null,"abstract":"Despite changing recommendations, aspirin is widely used for both primary and secondary prevention of vascular events such as myocardial infarction and","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82039849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sponsoring Organization: American Gastroenterological Association (AGA)BackgroundBecause the prevalence of nonalcoholic fatty liver disease (NAFLD) is
研究背景:非酒精性脂肪性肝病(NAFLD)的患病率是
{"title":"“Clinical Care Pathway” for Nonalcoholic Fatty Liver Disease","authors":"A. Brett","doi":"10.1056/NEJM-JW.NA54262","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54262","url":null,"abstract":"Sponsoring Organization: American Gastroenterological Association (AGA)BackgroundBecause the prevalence of nonalcoholic fatty liver disease (NAFLD) is","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87184449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Standard first-line chemotherapy for advanced cholangiocarcinoma is gemcitabine and cisplatin. Recent data support the use of FOLFOX as a second-line
晚期胆管癌的标准一线化疗方案是吉西他滨和顺铂。最近的数据支持使用FOLFOX作为二线治疗
{"title":"Liposome Encapsulated Irinotecan Is Active in Cholangiocarcinoma","authors":"D. Ilson","doi":"10.1056/NEJM-JW.NA54260","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54260","url":null,"abstract":"Standard first-line chemotherapy for advanced cholangiocarcinoma is gemcitabine and cisplatin. Recent data support the use of FOLFOX as a second-line","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87259878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vaccination-Associated Injection-Site Infections Before the COVID-19 Era","authors":"S. Baum","doi":"10.1056/NEJM-JW.NA54228","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54228","url":null,"abstract":"Vaccination has become a highly charged issue during the COVID-19 pandemic — but previously, millions of U.S. children and adults received","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74738312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Previously identified risk factors for treatment failure for community-acquired pneumonia (CAP) included advanced age, smoking, malnutrition, and
先前确定的社区获得性肺炎(CAP)治疗失败的危险因素包括高龄、吸烟、营养不良和
{"title":"Treatment Failure in Patients with Moderately Severe Community-Acquired Pneumonia","authors":"A. Parsons","doi":"10.1056/NEJM-JW.NA54212","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54212","url":null,"abstract":"Previously identified risk factors for treatment failure for community-acquired pneumonia (CAP) included advanced age, smoking, malnutrition, and","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89080005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Identifying patients at excess risk for severe COVID-19 is critical for devising treatment strategies (particularly those involving immune modulation)
确定严重COVID-19风险过高的患者对于制定治疗策略(特别是涉及免疫调节的治疗策略)至关重要。
{"title":"Anakinra: Timely Targeted Anticytokine Therapy for Severe COVID-19","authors":"N. Ampel","doi":"10.1056/NEJM-JW.NA54236","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54236","url":null,"abstract":"Identifying patients at excess risk for severe COVID-19 is critical for devising treatment strategies (particularly those involving immune modulation)","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87119403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinicians who care for adolescents with sports-related concussions typically recommend strict cognitive and physical rest, but some recent evidence
治疗青少年运动相关脑震荡的临床医生通常建议严格的认知和身体休息，但最近的一些证据表明
{"title":"Is Complete Rest Really the Best Treatment for Sports-Related Concussions?","authors":"J. Feinstein","doi":"10.1056/NEJM-JW.NA54190","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54190","url":null,"abstract":"Clinicians who care for adolescents with sports-related concussions typically recommend strict cognitive and physical rest, but some recent evidence","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87833456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
When patients with COVID-19 are admitted to the intensive care unit, guidelines recommend empirical coverage for bacterial superinfection with
当COVID-19患者入住重症监护病房时，指南建议对细菌重复感染进行经验性覆盖
{"title":"Bacterial Superinfection Is Found in a Minority of Patients Admitted with COVID-19 Respiratory Failure","authors":"P. Kritek","doi":"10.1056/NEJM-JW.NA54261","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54261","url":null,"abstract":"When patients with COVID-19 are admitted to the intensive care unit, guidelines recommend empirical coverage for bacterial superinfection with","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90665898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The immune system of a pregnant woman maintains a delicate balance: It must tolerate the “foreign” antigens of the fetus while still protecting the
孕妇的免疫系统保持着一种微妙的平衡:它必须容忍胎儿的“外来”抗原，同时仍然保护胎儿
{"title":"Second Doses of COVID-19 mRNA Vaccines Are Important in Pregnancy","authors":"A. Komaroff","doi":"10.1056/NEJM-JW.NA54254","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54254","url":null,"abstract":"The immune system of a pregnant woman maintains a delicate balance: It must tolerate the “foreign” antigens of the fetus while still protecting the","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86240148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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