Pub Date : 2025-12-10DOI: 10.1038/s41581-025-01040-2
Marina Wainstein, Elliot Koranteng Tannor
Although 2025 began with disruption and geopolitical retreat, momentum in kidney health advocacy endured. Global, regional and national efforts demonstrated that progress is possible when commitment persists and setbacks are recognized, offering opportunities to lessen the burden of kidney disease and improve access to equitable and sustainable kidney care.
{"title":"A year of disruption and progress in kidney health policy","authors":"Marina Wainstein, Elliot Koranteng Tannor","doi":"10.1038/s41581-025-01040-2","DOIUrl":"10.1038/s41581-025-01040-2","url":null,"abstract":"Although 2025 began with disruption and geopolitical retreat, momentum in kidney health advocacy endured. Global, regional and national efforts demonstrated that progress is possible when commitment persists and setbacks are recognized, offering opportunities to lessen the burden of kidney disease and improve access to equitable and sustainable kidney care.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"22 2","pages":"91-92"},"PeriodicalIF":39.8,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145718280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-09DOI: 10.1038/s41581-025-01041-1
Arnon Arazi, Betty Diamond
New studies in autoimmune kidney disease demonstrate the complex interplay between immune and non-immune cells that underlies kidney inflammation and fibrosis. Differences between these autoimmune responses and those observed in kidney allograft rejection, as well as insights from clinical responses to immunotherapy, provide further clues on key pathways driving kidney inflammation.
{"title":"The continued odyssey to unravel the secrets of kidney inflammation","authors":"Arnon Arazi, Betty Diamond","doi":"10.1038/s41581-025-01041-1","DOIUrl":"10.1038/s41581-025-01041-1","url":null,"abstract":"New studies in autoimmune kidney disease demonstrate the complex interplay between immune and non-immune cells that underlies kidney inflammation and fibrosis. Differences between these autoimmune responses and those observed in kidney allograft rejection, as well as insights from clinical responses to immunotherapy, provide further clues on key pathways driving kidney inflammation.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"22 2","pages":"93-94"},"PeriodicalIF":39.8,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145711024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41581-025-01039-9
Sophie Brouard, Nicolas Degauque
In 2025, several landmark studies illuminated the sequence of immune events that influence tolerance and rejection in kidney transplantation, from the molecular triggers of allorecognition to the chemotactic control of cytotoxicity and the protective mechanisms underlying the benefits of immune therapies. As xenotransplantation advances, these insights will also be important for achieving sustained xenograft tolerance.
{"title":"Kidney transplants: from antigen recognition to targeted therapy","authors":"Sophie Brouard, Nicolas Degauque","doi":"10.1038/s41581-025-01039-9","DOIUrl":"10.1038/s41581-025-01039-9","url":null,"abstract":"In 2025, several landmark studies illuminated the sequence of immune events that influence tolerance and rejection in kidney transplantation, from the molecular triggers of allorecognition to the chemotactic control of cytotoxicity and the protective mechanisms underlying the benefits of immune therapies. As xenotransplantation advances, these insights will also be important for achieving sustained xenograft tolerance.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"22 2","pages":"89-90"},"PeriodicalIF":39.8,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145704362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41581-025-01031-3
Amanda DeMauro Renaghan,Marlies Ostermann,Claudio Ronco,Karen Ballen,Laura Cosmai,Roberta Fenoglio,Matteo Floris,Lui G Forni,Douglas E Gladstone,Ilya G Glezerman,Stuart L Goldstein,Shruti Gupta,Sandra M Herrmann,Edgar A Jaimes,Kenar D Jhaveri,Sabine Karam,Abhijat Kitchlu,Heather J Landau,Sheron Latcha,David E Leaf,Paolo Lentini,Jolanta Małyszko,Glen Markowitz,Naoka Murakami,Antonello Pani,Mark A Perazella,Arash Rashidi,Dario Roccatello,Elad Sharon,Ben Sprangers,Vladimír Tesař,Verônica Torres,Rimda Wanchoo,Andrew Whitman,Biruh T Workeneh,Diana Zepeda-Orozco,Mitchell H Rosner
In the past few decades, advances in understanding of cancer biology have led to the development of highly effective conventional chemotherapies, targeted therapies that act on specific pathways that are critical to cancer growth, immune-based therapies, and cellular therapies such as haematopoietic cell transplantation and chimeric antigen receptor T cell therapy. However, the nephrotoxic effects of these therapies continue to pose substantial challenges, with many unanswered questions regarding the prevention, diagnosis and management of this nephrotoxicity. Further, a lack of consensus and precise guidance on kidney function estimation and drug dosing for patients with acute kidney disease or chronic kidney disease and for patients receiving kidney replacement therapy limits access to life-saving therapies and jeopardizes outcomes. In this Consensus Statement, we present guidance on the prevention, diagnosis and management of anticancer therapy nephrotoxicity for adult patients that was developed at the 34th Acute Disease Quality Initiative meeting, which convened an international panel of experts in nephrology, haematology, oncology, nephropathology, critical care, paediatric care and pharmacology. We also define a research agenda focused on preventing and mitigating anticancer therapy toxicity, maximizing early detection of nephrotoxicity and enabling optimal drug dosing in patients with kidney disease, with the goal of advancing cancer care and fulfilling the potential of these ground-breaking treatments.
{"title":"The nephrotoxic effects of anti-cancer therapies: consensus report of the 34th Acute Disease Quality Initiative workgroup.","authors":"Amanda DeMauro Renaghan,Marlies Ostermann,Claudio Ronco,Karen Ballen,Laura Cosmai,Roberta Fenoglio,Matteo Floris,Lui G Forni,Douglas E Gladstone,Ilya G Glezerman,Stuart L Goldstein,Shruti Gupta,Sandra M Herrmann,Edgar A Jaimes,Kenar D Jhaveri,Sabine Karam,Abhijat Kitchlu,Heather J Landau,Sheron Latcha,David E Leaf,Paolo Lentini,Jolanta Małyszko,Glen Markowitz,Naoka Murakami,Antonello Pani,Mark A Perazella,Arash Rashidi,Dario Roccatello,Elad Sharon,Ben Sprangers,Vladimír Tesař,Verônica Torres,Rimda Wanchoo,Andrew Whitman,Biruh T Workeneh,Diana Zepeda-Orozco,Mitchell H Rosner","doi":"10.1038/s41581-025-01031-3","DOIUrl":"https://doi.org/10.1038/s41581-025-01031-3","url":null,"abstract":"In the past few decades, advances in understanding of cancer biology have led to the development of highly effective conventional chemotherapies, targeted therapies that act on specific pathways that are critical to cancer growth, immune-based therapies, and cellular therapies such as haematopoietic cell transplantation and chimeric antigen receptor T cell therapy. However, the nephrotoxic effects of these therapies continue to pose substantial challenges, with many unanswered questions regarding the prevention, diagnosis and management of this nephrotoxicity. Further, a lack of consensus and precise guidance on kidney function estimation and drug dosing for patients with acute kidney disease or chronic kidney disease and for patients receiving kidney replacement therapy limits access to life-saving therapies and jeopardizes outcomes. In this Consensus Statement, we present guidance on the prevention, diagnosis and management of anticancer therapy nephrotoxicity for adult patients that was developed at the 34th Acute Disease Quality Initiative meeting, which convened an international panel of experts in nephrology, haematology, oncology, nephropathology, critical care, paediatric care and pharmacology. We also define a research agenda focused on preventing and mitigating anticancer therapy toxicity, maximizing early detection of nephrotoxicity and enabling optimal drug dosing in patients with kidney disease, with the goal of advancing cancer care and fulfilling the potential of these ground-breaking treatments.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"363 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145704361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1038/s41581-025-01037-x
Vishal Patel, Eun Ji Chung
Effective kidney-targeted therapeutics require careful consideration of both the cargo and carrier. In the past year, considerable progress has been made in the development of viral and non-viral delivery vehicles, by leveraging endogenous biological mechanisms, screening across multiple species and administration routes, and artificial intelligence to drive kidney selectivity.
{"title":"Bioengineering and nephrology converge to drive kidney-targeted therapies","authors":"Vishal Patel, Eun Ji Chung","doi":"10.1038/s41581-025-01037-x","DOIUrl":"10.1038/s41581-025-01037-x","url":null,"abstract":"Effective kidney-targeted therapeutics require careful consideration of both the cargo and carrier. In the past year, considerable progress has been made in the development of viral and non-viral delivery vehicles, by leveraging endogenous biological mechanisms, screening across multiple species and administration routes, and artificial intelligence to drive kidney selectivity.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"22 2","pages":"87-88"},"PeriodicalIF":39.8,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145599316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.1038/s41581-025-01025-1
Emilia Marie Scheidereit, Lampros Mavrommatis, Christoph Kuppe
{"title":"Cell–cell crosstalk in kidney health and disease","authors":"Emilia Marie Scheidereit, Lampros Mavrommatis, Christoph Kuppe","doi":"10.1038/s41581-025-01025-1","DOIUrl":"https://doi.org/10.1038/s41581-025-01025-1","url":null,"abstract":"","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"29 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145593717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1038/s41581-025-01028-y
Monica Gamez, Raina D. Ramnath, Matthew J. Butler, Rebecca R. Foster, Simon C. Satchell
{"title":"The glomerular endothelial glycocalyx as a therapeutic target in proteinuric kidney disease","authors":"Monica Gamez, Raina D. Ramnath, Matthew J. Butler, Rebecca R. Foster, Simon C. Satchell","doi":"10.1038/s41581-025-01028-y","DOIUrl":"https://doi.org/10.1038/s41581-025-01028-y","url":null,"abstract":"","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"11 1","pages":""},"PeriodicalIF":41.5,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145567238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1038/s41581-025-01035-z
Piero Ruggenenti, Giuseppe Remuzzi
Standard treatments to reduce cardiovascular risk, including mineralocorticoid receptor antagonists, have not lowered the high cardiovascular mortality and morbidity of patients on long-term haemodialysis. Future research should focus on targeting inflammatory pathways that are activated when blood interacts with dialysis membranes.
{"title":"Still searching for the right target for cardioprotection in haemodialysis","authors":"Piero Ruggenenti, Giuseppe Remuzzi","doi":"10.1038/s41581-025-01035-z","DOIUrl":"10.1038/s41581-025-01035-z","url":null,"abstract":"Standard treatments to reduce cardiovascular risk, including mineralocorticoid receptor antagonists, have not lowered the high cardiovascular mortality and morbidity of patients on long-term haemodialysis. Future research should focus on targeting inflammatory pathways that are activated when blood interacts with dialysis membranes.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"22 1","pages":"10-11"},"PeriodicalIF":39.8,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41581-025-01035-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145554136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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