Pub Date : 2021-09-30DOI: 10.20307/nps.2021.27.3.172
Tanjung Mulyadi, Fajar Aldin Muhammad, Srie Tjahjandarie Tjitjik, Oktari Rahayu Devina, Nur Irza Gunawan Alfiah, Dewi Saputri Ratih
{"title":"Sesbagrandiflorain F, a New 2-Arylbenzofuran from the Stem Bark of Sesbania grandiflora L.","authors":"Tanjung Mulyadi, Fajar Aldin Muhammad, Srie Tjahjandarie Tjitjik, Oktari Rahayu Devina, Nur Irza Gunawan Alfiah, Dewi Saputri Ratih","doi":"10.20307/nps.2021.27.3.172","DOIUrl":"https://doi.org/10.20307/nps.2021.27.3.172","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43810869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.20307/nps.2021.27.3.176
Khanh Vu Ngoc, T. Thi, M. Woo, B. Min
{"title":"Anti-inflammatory and Cytotoxic Activities of Phenolic Compounds from Broussonetia kazinoki","authors":"Khanh Vu Ngoc, T. Thi, M. Woo, B. Min","doi":"10.20307/nps.2021.27.3.176","DOIUrl":"https://doi.org/10.20307/nps.2021.27.3.176","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42139521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.20307/NPS.2021.27.3.183
Saputri Ratih Dewi, Tanjung Mulyadi, Tjahjandarie Tjitjik Srie
{"title":"Melixyloidin, A New Acridone Alkaloid from Melicope xanthoxyloides Leaves","authors":"Saputri Ratih Dewi, Tanjung Mulyadi, Tjahjandarie Tjitjik Srie","doi":"10.20307/NPS.2021.27.3.183","DOIUrl":"https://doi.org/10.20307/NPS.2021.27.3.183","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48301290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.20307/nps.2021.27.3.161
Thapa Punam, N. Katila, Hyukjae Choi, Ah-Reum Han, D. Choi, Joo-Won Nam
The chemical investigation of the 90% EtOH extract from Cicadidae Periostracum led to the isolation and identification of seven known N -acetyldopamine dimers ( 1-7 ). These compounds were identified by comparing mass spectrometry data and NMR spectroscopic data with those previously reported. In this study, complete interpretation of 1D and 2D NMR data of 1 and 2 were reported for the first time. In addition, compounds 3 and 4 were isolated from this material for the first time. All isolates were obtained as racemic mixtures, as confirmed by chiral HPLC. Furthermore, we evaluated the neuroprotective activities of compounds 1–7 and found that compounds 1 , 5 , and 6 significantly attenuated rotenone-induced death of SH-SY5Y neuroblastoma cells at a concentration of 100 M. Parallel to this result, compounds 3 and 6 displayed antioxidant effects in the cytoplasm, as determined by CM-H2DCFDA fluorescence intensity, while compounds 1 and 5 showed antioxidant effects in the mitochondria, as assessed by MitoSox fluorescence intensity. Overall, these results suggest that some of these compounds protect neuroblastoma cells by ameliorating the release of reactive oxygen species. Further studies are warranted to elucidate the underlying mechanisms by which these compounds exhibit antioxidant and neuroprotective actions
{"title":"Neuroprotective Effects of N-Acetyldopamine Dimers from Cicadidae Periostracum","authors":"Thapa Punam, N. Katila, Hyukjae Choi, Ah-Reum Han, D. Choi, Joo-Won Nam","doi":"10.20307/nps.2021.27.3.161","DOIUrl":"https://doi.org/10.20307/nps.2021.27.3.161","url":null,"abstract":" The chemical investigation of the 90% EtOH extract from Cicadidae Periostracum led to the isolation and identification of seven known N -acetyldopamine dimers ( 1-7 ). These compounds were identified by comparing mass spectrometry data and NMR spectroscopic data with those previously reported. In this study, complete interpretation of 1D and 2D NMR data of 1 and 2 were reported for the first time. In addition, compounds 3 and 4 were isolated from this material for the first time. All isolates were obtained as racemic mixtures, as confirmed by chiral HPLC. Furthermore, we evaluated the neuroprotective activities of compounds 1–7 and found that compounds 1 , 5 , and 6 significantly attenuated rotenone-induced death of SH-SY5Y neuroblastoma cells at a concentration of 100 M. Parallel to this result, compounds 3 and 6 displayed antioxidant effects in the cytoplasm, as determined by CM-H2DCFDA fluorescence intensity, while compounds 1 and 5 showed antioxidant effects in the mitochondria, as assessed by MitoSox fluorescence intensity. Overall, these results suggest that some of these compounds protect neuroblastoma cells by ameliorating the release of reactive oxygen species. Further studies are warranted to elucidate the underlying mechanisms by which these compounds exhibit antioxidant and neuroprotective actions","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47173439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.20307/nps.2021.27.3.187
Turk Ayman, B. Kim, Sung Min Ko, S. Yeon, S. Ryu, Young-Guk Kim, B. Hwang, M. Lee
{"title":"Optimization of Cultivation and Extraction Conditions of Pupae-Cordyceps for Cordycepin Production","authors":"Turk Ayman, B. Kim, Sung Min Ko, S. Yeon, S. Ryu, Young-Guk Kim, B. Hwang, M. Lee","doi":"10.20307/nps.2021.27.3.187","DOIUrl":"https://doi.org/10.20307/nps.2021.27.3.187","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42784868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.20307/nps.2021.27.2.128
Luana C. Crocoli, Vinícius B. Molon, Moura Sidnei
{"title":"The Use of qNMR for Quality Control of Coumarin-based Pharmaceuticals and Plant Medicines","authors":"Luana C. Crocoli, Vinícius B. Molon, Moura Sidnei","doi":"10.20307/nps.2021.27.2.128","DOIUrl":"https://doi.org/10.20307/nps.2021.27.2.128","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41593450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.20307/nps.2021.27.2.61
A. Mohd, Zakir Mohammad, Maseehullah Md, H. Munawwar
{"title":"Ethno-Pharmacological Profile of Corallium Rubrum L., an Important Marine Drug, in the Unani System of Medicine","authors":"A. Mohd, Zakir Mohammad, Maseehullah Md, H. Munawwar","doi":"10.20307/nps.2021.27.2.61","DOIUrl":"https://doi.org/10.20307/nps.2021.27.2.61","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48688386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.20307/nps.2021.27.2.78
Sara N. Suliman, Mai H. ElNaggar, Elsbaey Marwa, Mohammed M. El‐Gamil, F. Badria
{"title":"Bio-guided Isolation of Natural Iron Chelators from Mangifera indica Leaves and their Comparative Study to Desferal®","authors":"Sara N. Suliman, Mai H. ElNaggar, Elsbaey Marwa, Mohammed M. El‐Gamil, F. Badria","doi":"10.20307/nps.2021.27.2.78","DOIUrl":"https://doi.org/10.20307/nps.2021.27.2.78","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68202005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A new steroidal saponin, (23 S ,24 S )-spirosta-5,25(27)-diene-1 β ,3 β ,23,24-tetrol 1- O-((2,3-diacetyl-α-L-rhamnopyranosyl)-(1→2)-[ β -D-xylopyranosyl-(1→3)]- α -L-arabinopyranoside)-24- O - β -D-glucopyranoside (humilisoside) together with the known β -sitosterol 3-O -glucopyranoside, adenosine, dioscin, and methylprotodioscin were isolated from the leaves of Dracaena humilis . Their structures were elucidated by spectral techniques including mass spectrometry (ESIMS, HRESIMS, tandem MS-MS), 1D NMR ( 1 H, 13 C NMR), 2D NMR (HSQC, 1 H-1 H COSY, HMBC, NOESY), chemical method as well as by comparison with spectroscopic data reported in the literature. The chemotaxonomic significance of the isolation of these compounds is discussed. This is the first report on the phytochemical investigation of D. humilis .
{"title":"Steroidal Saponins from Dracaena humilis (Dracaenaceae) and their Chemotaxonomic Significance","authors":"Mbiesset Mouzié Cédric, Kemvoufo Ponou Beaudelaire, Tematio Fouedjou Romuald, B. Rémy, Azefack Tapondjou Léon","doi":"10.20307/nps.2021.27.2.122","DOIUrl":"https://doi.org/10.20307/nps.2021.27.2.122","url":null,"abstract":" A new steroidal saponin, (23 S ,24 S )-spirosta-5,25(27)-diene-1 β ,3 β ,23,24-tetrol 1- O-((2,3-diacetyl-α-L-rhamnopyranosyl)-(1→2)-[ β -D-xylopyranosyl-(1→3)]- α -L-arabinopyranoside)-24- O - β -D-glucopyranoside (humilisoside) together with the known β -sitosterol 3-O -glucopyranoside, adenosine, dioscin, and methylprotodioscin were isolated from the leaves of Dracaena humilis . Their structures were elucidated by spectral techniques including mass spectrometry (ESIMS, HRESIMS, tandem MS-MS), 1D NMR ( 1 H, 13 C NMR), 2D NMR (HSQC, 1 H-1 H COSY, HMBC, NOESY), chemical method as well as by comparison with spectroscopic data reported in the literature. The chemotaxonomic significance of the isolation of these compounds is discussed. This is the first report on the phytochemical investigation of D. humilis .","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42928828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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