Neurobiology of Aging最新文献_第6页

Age-associated trajectories of hippocampus subregion volumes from childhood through later adulthood 从童年到成年后期海马亚区体积的年龄相关轨迹

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging

Pub Date : 2025-08-13 DOI: 10.1016/j.neurobiolaging.2025.08.002

Suril Gohel , Chi C. Chan , Isabelle Baptista , Philip R. Szeszko

The hippocampus has been widely implicated in the neurobiology of neurologic and psychiatric disorders. This structure is heterogeneous, however, and comprised of multiple subregions that have different connectivity patterns and functions. Better understanding how these subregions are affected by age and their relationship with neurocognition could provide information regarding how alterations in normal trajectories play a role in disease and cognitive dysfunction. Using natural splines we modeled the trajectory of 4 hippocampus subregions (i.e., CA composite, DG composite, tail and subiculum) derived from automated segmentation of magnetic resonance images using FreeSurfer in a cohort of 674 (440F/234M) healthy individuals ranging in age from 6 to 85 years. Following adjustment for covariates the best fitting model for all subregions was a spline with 2 degrees of freedom, which included one internal knot and two boundary knots. The peak age at which all subregions achieved maximum volume occurred in the fourth decade of life. Prior to the peak age there was no significant mediating effect of hippocampus subregion volume on the relationship between age and memory. Following the peak age, however, hippocampal subregions partially mediated the relationship between age and memory performance with the proportion mediated ranging from 11 % (subiculum) to 17 % (CA composite), but with no significant effects observed for the tail. These findings provide novel information regarding the trajectory of individual hippocampus subregion volumes across the age span and suggest they mediate the relationship between age and memory performance.

海马体与神经和精神疾病的神经生物学有着广泛的联系。然而，这种结构是异构的，由具有不同连接模式和功能的多个子区域组成。更好地了解这些亚区如何受到年龄的影响，以及它们与神经认知的关系，可以提供关于正常轨迹的改变如何在疾病和认知功能障碍中发挥作用的信息。利用FreeSurfer对674名（440F/234M）年龄在6岁至85岁之间的健康个体的磁共振图像进行自动分割，我们利用自然样条模型模拟了4个海马亚区（即CA复合区、DG复合区、尾区和下托区）的轨迹。在协变量调整后，所有子区域的最佳拟合模型是2自由度的样条曲线，其中包括一个内部结和两个边界结。所有分区域实现最大体积的高峰年龄发生在生命的第四个十年。在峰值年龄之前，海马次区域体积对年龄与记忆的关系没有显著的中介作用。然而，在峰值年龄之后，海马亚区部分介导了年龄与记忆表现之间的关系，介导的比例从11. %（下骨）到17. % （CA复合）不等，但对尾巴没有显著影响。这些发现提供了关于个体海马体亚区体积在年龄范围内的轨迹的新信息，并表明它们介导了年龄和记忆表现之间的关系。

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引用次数: 0

Cerebral small-vessel disease severity, hypertension, and body mass index forecast striatal dopamine D2-receptor decline rates in aging 脑血管疾病的严重程度、高血压和体重指数预测纹状体多巴胺d2受体在衰老中的下降率

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging

Pub Date : 2025-08-06 DOI: 10.1016/j.neurobiolaging.2025.08.001

Nina Karalija , Vanessa Crine , Anders Wåhlin , Jarkko Johansson , Goran Papenberg , Micael Andersson , Katrine Riklund , Martin Lövdén , Ulman Lindenberger , Lars Bäckman , Lars Nyberg

Normal aging is associated with decline in dopamine function. Factors associated with individual differences in dopamine decline rates remain unclear but are important to map to spare dopamine-related functions, such as cognition. Here we focused on manifestations of cerebral small-vessel disease from magnetic resonance imaging (white-matter lesions, lacunes, and perivascular space dilation) and vascular risk factors (e.g., hypertension, body mass index (BMI), and hyperlipidemia). We assessed striatal dopamine D2-like receptor (DRD2) reductions across five years in healthy, older adults (n = 129, ages: 64–68 years at baseline) using ¹¹C-raclopride/positron emission tomography. Manifestations of confluent lesions and lacunes at baseline had additive effects on DRD2 decline. Individuals with both manifestations showed fastest DRD2 decline rates (∼ −4 %), followed by those with one manifestation (∼ −2 %), whereas individuals spared of confluent lesions and lacunes showed stable DRD2 levels over time (∼ 0 % change). Furthermore, individuals with confluent lesions or lacunes showed more marked decline in perceptual speed performance, as compared to individuals spared of these manifestations (p < 0.05). Higher systolic blood pressure and lower BMI at baseline were associated with faster 5-year DRD2 decline in the putamen (r = -0.17, p < 0.05) and caudate (r = 0.23, p < 0.05), respectively. Together, confluent lesions and lacunes explained up to 8 % of striatal DRD2 change, and up to 10 % when adding hypertension and BMI to the model. These findings suggest that hallmarks of SVD and certain vascular risk factors predispose faster DRD2 decline in aging and may thus serve as factors to consider in future interventions.

正常的衰老与多巴胺功能下降有关。与多巴胺下降率的个体差异相关的因素尚不清楚，但对于绘制与多巴胺相关的功能（如认知）很重要。在这里，我们主要关注脑小血管疾病的磁共振成像表现（白质病变、腔隙和血管周围空间扩张）和血管危险因素（如高血压、体重指数（BMI）和高脂血症）。我们使用11C-raclopride/正电子发射断层扫描评估了健康老年人（n = 129，基线年龄：64-68岁）五年内纹状体多巴胺d2样受体（DRD2）的减少。基线时融合性病变和凹窝的表现对DRD2下降有累加性影响。具有两种表现的个体DRD2下降速度最快（~ - 4 %），其次是具有一种表现的个体（~ - 2 %），而没有融合性病变和陷窝的个体随着时间的推移显示稳定的DRD2水平（~ 0 %变化）。此外，与没有这些表现的个体相比，具有融合性病变或凹窝的个体表现出更明显的知觉速度性能下降（p <； 0.05）。较高的收缩压和较低的基线BMI分别与壳核（r = -0.17,p <； 0.05）和尾状核（r = 0.23,p <； 0.05）更快的5年DRD2下降相关。合并病变和凹窝共同解释纹状体DRD2变化高达8 %，在模型中加入高血压和BMI时高达10 %。这些发现表明，SVD的特征和某些血管危险因素易导致DRD2在衰老过程中更快下降，因此可能成为未来干预措施的考虑因素。

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引用次数: 0

Corrigendum to “Elevation of cytoskeletal protein breakdown in aged Wistar rat brain” [Neurobiol. Aging 27 (2006) 624–632] “老年Wistar大鼠脑中细胞骨架蛋白分解的升高”的更正[神经生物学]。老龄化27(2006)624-632]。

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging

Pub Date : 2025-08-05 DOI: 10.1016/j.neurobiolaging.2025.04.004

Eric Bernath , Nancy Kupina , Ming Cheng Liu , Ronald L. Hayes , Colleen Meegan , Kevin K.W. Wang

引用次数: 0

The moderating effect of cognitive reserve on the association between neuroimaging biomarkers and cognition: A systematic review 认知储备对神经成像生物标志物与认知关联的调节作用：系统综述

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging

Pub Date : 2025-07-30 DOI: 10.1016/j.neurobiolaging.2025.07.016

Lizhi Guo , Yajing Zhou , Hanna Lu , Helene H. Fung

This systematic review aims to investigate the moderating effects of cognitive reserve (CR) on the relationships between cognitive function and multimodal Alzheimer’s disease (AD)-signatured brain changes, measured by positron emission tomography (PET), structural magnetic resonance imaging (sMRI) and functional MRI (fMRI). Through a comprehensive search of PubMed, Scopus, and Web of Science, we identified 55 eligible studies examining the moderating effect of CR on the relationship between neuroimaging biomarkers and cognitive outcomes. CR measurements include sociobehavioral proxies (e.g., education, leisure activities), residual approaches, and functional imaging approaches. Findings were mixed. Of the fifty-five studies, 41 studies reported a protective effect of CR, suggesting its buffering effect against cognitive decline or AD progression during ageing. However, eleven studies reported no interaction between CR and neuroimaging biomarkers. Six studies suggested a detrimental effect of CR in the middle-to-late stages of the disease [e.g., mild cognitive impairment (MCI) and AD] (three studies reported both protective and detrimental effects). The discrepancies may reflect that the influence of CR on the association between neuroimaging biomarkers and cognitive function depends on disease stage. In early stages, it exhibits protective effects, but as pathology accumulates, it may accelerate cognitive decline. This review revealed CR has heterogeneous effects on AD progression. We preliminarily identified a “critical point” for CR within the continuum between cognitively unimpaired (CU) and MCI, although its precise pathological determinants require further clarification. Establishing standardized CR metrics and conducting longitudinal biomarker-integrated studies are critical to pinpoint optimal intervention windows for maximizing CR’s protective effects.

本系统综述旨在通过正电子发射断层扫描（PET）、结构磁共振成像（sMRI）和功能磁共振成像（fMRI）测量认知储备（CR）在认知功能与多模态阿尔茨海默病（AD）特征脑变化之间的关系中的调节作用。通过对PubMed、Scopus和Web of Science的全面搜索，我们确定了55项符合条件的研究，这些研究检验了CR对神经成像生物标志物和认知结果之间关系的调节作用。CR测量包括社会行为代理（如教育、休闲活动）、残差方法和功能成像方法。调查结果喜忧参半。在55项研究中，41项研究报告了CR的保护作用，表明其对衰老过程中认知能力下降或AD进展的缓冲作用。然而，11项研究报告CR与神经成像生物标志物之间没有相互作用。六项研究表明，CR在疾病的中晚期有不利影响[例如，轻度认知障碍（MCI）和AD]（三项研究报告了保护作用和有害作用）。这些差异可能反映了CR对神经成像生物标志物与认知功能相关性的影响取决于疾病分期。在早期阶段，它表现出保护作用，但随着病理积累，它可能会加速认知能力的下降。这篇综述揭示了CR对AD进展的异质性影响。我们初步确定了认知未受损（CU）和MCI之间连续体中CR的“临界点”，尽管其确切的病理决定因素需要进一步澄清。建立标准化的CR指标并进行纵向生物标志物整合研究对于确定最佳干预窗口以最大化CR保护作用至关重要。

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引用次数: 0

The relationship between racial discrimination and white matter among Black older adults 黑人老年人种族歧视与白质的关系

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging

Pub Date : 2025-07-30 DOI: 10.1016/j.neurobiolaging.2025.07.017

Jordan D. Palms , Ji Hyun Lee , Emily P. Morris , Ketlyne Sol , Monica E. Walters , Kiana A. Scambray , Clarissa D. Morales , Mohamad J. Alshikho , Patrick J. Lao , Jennifer J. Manly , Adam M. Brickman , Laura B. Zahodne

Black older adults experience worse brain and cognitive aging than White older adults, on average. Racially patterned psychosocial stressors may contribute to these disparities. Maintaining white matter health is important for cognitive aging, particularly among Black older adults, and it is uniquely vulnerable to stress. Examining associations between racial discrimination and white matter may elucidate mechanisms of disparities. A sample of Black older adults in the Washington Heights-Inwood Columbia Aging project were included (N = 217). Everyday and major life discrimination were self-reported on well-validated scales. Diffusion tensor imaging quantified white matter fractional anisotropy (FA). Multivariable regressions revealed more major life discrimination was associated with lower FA in the cingulum cingulate gyrus, forceps major, forceps minor, and inferior fronto-occipital fasciculus but greater FA in the superior longitudinal fasciculus temporal projection. Everyday discrimination was not associated with FA. Findings suggest that institutional racism may have a stronger effect on white matter tracts corresponding to cognitive and emotional/affective processing than interpersonal racism. White matter health may be a mechanism through which racially patterned stressors contribute to disparities in brain and cognitive aging.

平均而言，黑人老年人的大脑和认知老化情况比白人老年人更严重。种族模式的社会心理压力源可能导致这些差异。保持白质的健康对认知老化很重要，尤其是在黑人老年人中，而且它特别容易受到压力的影响。研究种族歧视和白质之间的联系可以阐明差异的机制。纳入了华盛顿高地-因伍德-哥伦比亚老龄化项目的黑人老年人样本（N = 217）。日常生活和重大生活歧视都是在经过验证的量表上自我报告的。扩散张量成像量化白质分数各向异性（FA）。多变量回归显示，更多的重大生活区分与扣带回、大钳、小钳和额枕下束的FA较低相关，但与上纵束颞投影的FA较高相关。日常歧视与FA无关。研究结果表明，与人际种族主义相比，制度性种族主义可能对与认知和情绪/情感处理相关的白质束有更强的影响。白质健康可能是一种机制，通过这种机制，种族模式的压力源会导致大脑和认知衰老的差异。

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引用次数: 0

High estimated pulse-wave velocity is associated with lower brain white matter microstructural integrity twelve years later 高估计的脉冲波速度与12年后较低的脑白质微结构完整性有关

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging

Pub Date : 2025-07-28 DOI: 10.1016/j.neurobiolaging.2025.07.015

Kevin S. Heffernan , Derek C. Monroe , Andrew S. London , Jose Gutierrez , Adam M. Brickman , Ajay Kumar Nair , Nagesh Adluru , Stacey M. Schaefer

High pulse wave velocity (PWV), a measure of increased arterial stiffness, is a risk factor for cerebrovascular disease. PWV can be estimated (ePWV) from age and blood pressure (BP). Elevated ePWV is associated with cerebral small-vessel disease, cognitive decline, and dementia risk in middle-aged and older adults. We examined data from the Midlife in the United States (MIDUS) Neuroscience Project to examine the association of ePWV with brain white matter microstructure. BP was measured in 132 middle-aged adults (mean age 53+/- 10 years, n = 77 women, n = 38 Black/African American) between 2004 and 2009 and used to calculate ePWV. Diffusion-weighted imaging (DWI) data were acquired between 2017 and 2022 and used to estimate: global white matter fractional anisotropy; axial, radial, and mean diffusivity and kurtosis; neurite density index; and orientation dispersion index. High ePWV was associated with: lower fractional anisotropy; axial, radial, and mean kurtosis; and neurite density index. High ePWV was also associated with higher axial, radial, and mean diffusivity, and orientation dispersion index. Except for axial diffusivity/kurtosis and orientation dispersion, all associations between high ePWV and white matter microstructure remained after adjusting for exogenous controls (sex and race), education, the constituent components of ePWV (age and blood pressure), and the time lag between BP and DWI measures. In conclusion, high ePWV in middle-aged adults is prospectively associated with compromised brain white matter microstructure more than a decade later. ePWV may be a useful metric of vascular aging that can be applied to the study of brain aging.

高脉搏波速度（PWV）是衡量动脉硬度增加的一种指标，是脑血管疾病的一个危险因素。PWV （ePWV）可以通过年龄和血压（BP）来估计。ePWV升高与中老年人脑血管疾病、认知能力下降和痴呆风险相关。我们研究了来自美国中年神经科学项目（MIDUS）的数据，以研究ePWV与脑白质微观结构的关系。在2004年至2009年期间测量了132名中年人（平均年龄53+/- 10岁，n = 77名女性，n = 38名黑人/非裔美国人）的血压，并用于计算ePWV。2017年至2022年期间获取的弥散加权成像（DWI）数据用于估计：全球白质分数各向异性；轴向、径向和平均扩散系数和峰度；神经突密度指数；取向色散指数。高ePWV与：低分数各向异性相关；轴向、径向和平均峰度；神经突密度指数。高ePWV还与较高的轴向、径向和平均扩散系数以及取向弥散指数相关。除了轴向扩散率/峰度和取向分散外，在调整了外源控制（性别和种族）、教育、ePWV组成成分（年龄和血压）以及BP和DWI测量之间的时间滞后后，高ePWV与白质微观结构之间的所有关联仍然存在。综上所述，中年成人高ePWV可能与10多年后脑白质微结构受损有关。ePWV可能是一种有用的血管老化指标，可以应用于脑老化的研究。

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引用次数: 0

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging

Pub Date : 2025-07-24 DOI: 10.1016/j.neurobiolaging.2025.07.014

Maxime Perron , Hannah Shatzer , Michael Zara , Frank Russo

Cognitive aging is associated with increased prefrontal cortex (PFC) activity, often interpreted as either a compensatory mechanism or a sign of neural inefficiency. In the context of speech-in-noise perception, it remains unclear whether this increase supports or impairs performance, as findings across studies are mixed. This study investigated age-related differences in PFC activity during sentence comprehension in noise using functional near-infrared spectroscopy. Fifty-seven participants (22 younger adults, 35 older adults) listened to sentences ending in either a high- or low-predictability word under two signal-to-noise ratio (SNR) conditions. Older adults showed increased PFC activity as SNR decreased, whereas younger adults showed no significant modulation. Among older adults, lower performers exhibited the greatest right-lateralized PFC activity, suggesting the recruitment of suboptimal neural resources. At the trial level, incorrect responses were associated with greater bilateral PFC activity in both age groups. Mediation analyses revealed that the negative effect of age on performance was partially explained by increased bilateral PFC activity, indicating that overactivation contributes to age-related speech-in-noise difficulties. Hearing loss and cognitive ability did not predict overall PFC activity but moderated the effect of SNR on PFC activity. Specifically, older adults with better hearing or higher cognitive scores showed increased PFC activity in the difficult SNR condition compared to the easier one, whereas those with more hearing loss or lower cognition showed similar activity across conditions. No effects of sentence predictability were observed. These findings support a neural inefficiency framework and highlight the importance of addressing PFC overactivation to improve speech-in-noise communication in older adults.

认知老化与前额皮质（PFC）活动增加有关，通常被解释为一种补偿机制或神经效率低下的迹象。在噪音中语音感知的背景下，目前尚不清楚这种增加是支持还是损害了表现，因为所有研究的结果都是混合的。本研究利用功能近红外光谱研究了噪声环境下句子理解过程中PFC活动的年龄差异。57名参与者（22名年轻人，35名老年人）在两种信噪比（SNR）条件下听了以高可预测性或低可预测性单词结尾的句子。随着信噪比的降低，老年人的PFC活动增加，而年轻人则没有明显的调节。在老年人中，表现较差的人表现出最大的右偏侧PFC活动，表明招募了次优的神经资源。在试验阶段，在两个年龄组中，不正确的反应与更大的双侧PFC活动有关。中介分析显示，年龄对表现的负面影响部分可以通过双侧PFC活动的增加来解释，这表明过度激活会导致与年龄相关的噪音言语困难。听力损失和认知能力不能预测PFC的整体活动，但可以调节信噪比对PFC活动的影响。具体来说，听力较好或认知得分较高的老年人在难信噪比条件下的PFC活动比容易信噪比条件下的PFC活动增加，而听力损失较重或认知能力较低的老年人在不同条件下的PFC活动相似。没有观察到句子可预测性的影响。这些发现支持了一个神经效率低下的框架，并强调了解决PFC过度激活对改善老年人噪音中言语交流的重要性。

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引用次数: 0

Neural network mechanisms of emotional dysregulation in cerebral small vessel disease 脑血管病情绪失调的神经网络机制

IF 3.7 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging

Pub Date : 2025-07-20 DOI: 10.1016/j.neurobiolaging.2025.07.013

Olga R. Dobrushina , Larisa A. Dobrynina , Galina A. Arina , Evgenia S. Novikova , Mariia M. Tsypushtanova , Angelina G. Makarova , Mariia V. Gubanova , Viktoriya V. Trubitsyna , Vlada V. Kolomoitseva , Daria A. Kazantseva , Elena I. Kremneva , Marina V. Krotenkova

Cerebral small vessel disease (CSVD) is a prevalent age-related disorder that leads to progressive white matter damage, resulting in cognitive decline and depression. This study explored the neural network mechanisms of emotional dysregulation in CSVD, focusing on both depression and alexithymia and considering the broader context of studies on emotional cardiovascular risk factors. Study participants (n = 196, age 37–75) were assessed for CSVD, arterial hypertension, depressive symptoms, and alexithymia. Emotional dysregulation, defined by depression and alexithymia, was estimated using a structural equation model accounting for the potential of bidirectional links with CSVD. To investigate the connectivity of networks involved in emotional processing, 167 participants underwent resting-state functional MRI. The study showed that emotional dysregulation was associated with reduced functional connectivity between the salience and language networks and within the language network. Age was associated with reduced functional connectivity within the salience and language networks, suggesting a possibility of synergistic deleterious effects. The revealed alterations in brain connectivity might reflect the dysfunction of the system of allostasis, explaining the observed symptoms of depression and alexithymia, as well as the previous findings on emotional cardiovascular risk factors.

脑血管病（CSVD）是一种常见的年龄相关疾病，可导致进行性白质损伤，导致认知能力下降和抑郁。本研究探讨了CSVD中情绪失调的神经网络机制，重点关注抑郁和述情障碍，并考虑到更广泛的情绪心血管危险因素的研究背景。研究参与者（n = 196名，年龄37-75岁）评估CSVD、动脉高血压、抑郁症状和述情障碍。由抑郁和述情障碍定义的情绪失调，使用结构方程模型估计了与CSVD双向联系的可能性。为了研究参与情绪处理的网络的连通性，167名参与者接受了静息状态功能MRI检查。研究表明，情绪失调与显著性和语言网络之间以及语言网络内部的功能连接减少有关。年龄与显著性和语言网络内功能连接的减少有关，这表明可能存在协同有害影响。所揭示的大脑连通性的改变可能反映了适应平衡系统的功能障碍，解释了观察到的抑郁和述情障碍症状，以及之前关于情绪性心血管危险因素的发现。

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引用次数: 0

Hypothalamic imaging in Alzheimer’s disease and Lewy body dementia: A systematic review and meta-analysis 阿尔茨海默病和路易体痴呆的下丘脑成像：系统回顾和荟萃分析

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging

Pub Date : 2025-07-18 DOI: 10.1016/j.neurobiolaging.2025.07.011

Axel AS Laurell , Sita N. Shah , Masoud Rahmati , John T. O’Brien , Benjamin R. Underwood

Symptoms related to sleep, weight, and endocrine dysfunction are common in Alzheimer’s disease (AD) and Lewy body dementia (LBD). The cause of these symptoms is not known, but they may be related to hypothalamic neurodegeneration. We performed a systematic search of MEDLINE and EMBASE for studies using MRI or PET imaging to examine the hypothalamus in AD or LBD. The Newcastle-Ottawa scale was used to assess the risk of bias. A random-effects meta-analysis was conducted using the standardised mean difference (SMD) in hypothalamic volume, and a narrative synthesis was used to examine associations between hypothalamic imaging and sleep, weight, and endocrine function. We screened 8891 articles which identified 22 studies for inclusion in the narrative synthesis of which 6 were suitable for meta-analysis. 86 % had a low to moderate risk of bias. People with mild-moderate AD had a smaller hypothalamus compared to controls (SMD=-0.49[-0.86,-0.13],p = 0.018;I²=67 %[21.5 %-86.1 %];n = 454(AD),715(controls)), and had differences in hypothalamic metabolism and connectivity. Two studies in LBD found lower grey matter and serotonin transporter binding in the hypothalamus compared to controls. Hypothalamic differences in AD were associated with male sex, worse sleep, lower bone mineral density and plasma levels of sex hormones. Body mass index was not associated with hypothalamic volume in AD, although further studies are needed. Lower hypothalamic volume is seen in AD and this may influence sleep and endocrine function. A better understanding of hypothalamic degeneration may help elucidate how pathology relates to symptoms in AD and LBD and reveal new targets for intervention.

与睡眠、体重和内分泌功能障碍相关的症状在阿尔茨海默病（AD）和路易体痴呆（LBD）中很常见。这些症状的原因尚不清楚，但它们可能与下丘脑神经变性有关。我们在MEDLINE和EMBASE中进行了系统的搜索，寻找使用MRI或PET成像检查AD或LBD患者下丘脑的研究。纽卡斯尔-渥太华量表用于评估偏倚风险。使用下丘脑体积的标准化平均差（SMD）进行随机效应荟萃分析，并使用叙事综合来检查下丘脑成像与睡眠、体重和内分泌功能之间的关系。我们筛选了8891篇文章，确定了22项研究纳入叙事综合，其中6项适合进行meta分析。86% %具有低至中等偏倚风险。与对照组相比，轻度-中度AD患者下丘脑较小(SMD=-0.49[-0.86,-0.13],p = 0.018;I2=67 %[21.5 %-86.1 %];n = 454（AD),715（对照）），下丘脑代谢和连通性存在差异。两项关于LBD的研究发现，与对照组相比，下丘脑的灰质和血清素转运体结合较低。阿尔茨海默病的下丘脑差异与男性、较差的睡眠、较低的骨密度和血浆性激素水平有关。身体质量指数与阿尔茨海默病患者的下丘脑体积无关，但还需要进一步的研究。阿尔茨海默病患者下丘脑体积较低，这可能影响睡眠和内分泌功能。更好地了解下丘脑变性可能有助于阐明病理与AD和LBD症状的关系，并揭示新的干预靶点。

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引用次数: 0

Integrating plasma, MRI, and cognitive biomarkers for personalized prediction of decline across cognitive domains 整合血浆、MRI和认知生物标志物，个性化预测认知领域的衰退

IF 3.7 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging

Pub Date : 2025-07-18 DOI: 10.1016/j.neurobiolaging.2025.06.010

Elaheh Moradi , Robert Dahnke , Vandad Imani , Christian Gaser , Alina Solomon , Jussi Tohka , Alzheimer’s Disease Neuroimaging Initiative

Plasma biomarkers are associated with cognitive performance and decline in Alzheimer’s disease, making them promising for early detection. This study investigates their predictive value, combined with non-invasive measures, in forecasting cognitive decline in individuals without dementia. We developed a multimodal machine-learning approach incorporating plasma biomarkers (Amyloid

β

42/40 (A

β

42/40), p-tau181, NfL), MRI, demographics, APOE4, and cognitive assessments to predict the rate of cognitive decline. Various models were designed to predict decline rates across cognitive domains (memory, executive function, language, and visuospatial abilities) and assess their relevance in predicting dementia progression. Cross-validated correlations between predicted and actual cognitive decline rates were 0.50 for memory, 0.49 for language, 0.42 for executive function, and 0.44 for visuospatial ability. MRI showed greater predictive importance than plasma biomarkers. Among plasma biomarkers, NfL and p-tau181 outperformed A

β

42/40. Predicting cognitive decline and progression to MCI/dementia was most accurate in the memory domain, where plasma biomarkers (A

β

42/40, p-tau181, NfL) added significant value to predictive models, likely due to their AD-specific nature. Plasma biomarkers contributed less to predictions in other cognitive domains. The results indicate that plasma biomarkers, particularly when combined with MRI, demographics, APOE4, and cognitive measures, have significant potential for predicting memory decline and assessing the risk of dementia progression, even in cognitively unimpaired individuals.

血浆生物标志物与阿尔茨海默病的认知能力和衰退有关，这使得它们有望被早期发现。本研究调查了它们的预测价值，结合非侵入性测量，预测无痴呆个体的认知能力下降。我们开发了一种多模式机器学习方法，结合血浆生物标志物（淀粉样蛋白β42/40 (a β42/40), p-tau181, NfL）， MRI，人口统计学，APOE4和认知评估来预测认知能力下降的速度。设计了各种模型来预测认知领域（记忆、执行功能、语言和视觉空间能力）的衰退率，并评估它们在预测痴呆进展中的相关性。交叉验证的预测和实际认知能力下降率之间的相关性为：记忆0.50，语言0.49，执行功能0.42，视觉空间能力0.44。MRI表现出比血浆生物标志物更大的预测重要性。在血浆生物标志物中，NfL和p-tau181优于Aβ42/40。预测认知能力下降和MCI/痴呆的进展在记忆领域是最准确的，其中血浆生物标志物（Aβ42/40, p-tau181, NfL）为预测模型增加了显著价值，可能是由于它们的ad特异性。血浆生物标志物对其他认知领域的预测贡献较小。结果表明，血浆生物标志物，特别是与MRI、人口统计学、APOE4和认知测量相结合时，即使在认知功能未受损的个体中，也具有预测记忆衰退和评估痴呆进展风险的显著潜力。

{"title":"Integrating plasma, MRI, and cognitive biomarkers for personalized prediction of decline across cognitive domains","authors":"Elaheh Moradi , Robert Dahnke , Vandad Imani , Christian Gaser , Alina Solomon , Jussi Tohka , Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.neurobiolaging.2025.06.010","DOIUrl":"10.1016/j.neurobiolaging.2025.06.010","url":null,"abstract":"<div><div>Plasma biomarkers are associated with cognitive performance and decline in Alzheimer’s disease, making them promising for early detection. This study investigates their predictive value, combined with non-invasive measures, in forecasting cognitive decline in individuals without dementia. We developed a multimodal machine-learning approach incorporating plasma biomarkers (Amyloid<span><math><mi>β</mi></math></span>42/40 (A<span><math><mi>β</mi></math></span>42/40), p-tau181, NfL), MRI, demographics, APOE4, and cognitive assessments to predict the rate of cognitive decline. Various models were designed to predict decline rates across cognitive domains (memory, executive function, language, and visuospatial abilities) and assess their relevance in predicting dementia progression. Cross-validated correlations between predicted and actual cognitive decline rates were 0.50 for memory, 0.49 for language, 0.42 for executive function, and 0.44 for visuospatial ability. MRI showed greater predictive importance than plasma biomarkers. Among plasma biomarkers, NfL and p-tau181 outperformed A<span><math><mi>β</mi></math></span>42/40. Predicting cognitive decline and progression to MCI/dementia was most accurate in the memory domain, where plasma biomarkers (A<span><math><mi>β</mi></math></span>42/40, p-tau181, NfL) added significant value to predictive models, likely due to their AD-specific nature. Plasma biomarkers contributed less to predictions in other cognitive domains. The results indicate that plasma biomarkers, particularly when combined with MRI, demographics, APOE4, and cognitive measures, have significant potential for predicting memory decline and assessing the risk of dementia progression, even in cognitively unimpaired individuals.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"155 ","pages":"Pages 53-65"},"PeriodicalIF":3.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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