Pub Date : 2025-01-28DOI: 10.1016/j.neurobiolaging.2025.01.006
Jenna L. Merenstein , Jiayi Zhao , David J. Madden
Age-related differences in fluid cognition have been associated with both the merging of functional brain networks, defined from resting-state functional magnetic resonance imaging (rsfMRI), and with elevated cortical iron, assessed by quantitative susceptibility mapping (QSM). Limited information is available, however, regarding the depthwise profile of cortical iron and its potential relation to functional connectivity. Here, using an adult lifespan sample (n = 138; 18–80 years), we assessed relations among graph theoretical measures of functional connectivity, column-based depthwise measures of cortical iron, and fluid cognition (i.e., tests of memory, perceptual-motor speed, executive function). Increased age was related both to less segregated functional networks and to increased cortical iron, especially for superficial depths. Functional network segregation mediated age-related differences in memory, whereas depthwise iron mediated age-related differences in general fluid cognition. Lastly, higher mean parietal iron predicted lower network segregation for adults younger than 45 years of age. These findings suggest that functional connectivity and depthwise cortical iron have distinct, complementary roles in the relation between age and fluid cognition in healthy adults.
{"title":"Depthwise cortical iron relates to functional connectivity and fluid cognition in healthy aging","authors":"Jenna L. Merenstein , Jiayi Zhao , David J. Madden","doi":"10.1016/j.neurobiolaging.2025.01.006","DOIUrl":"10.1016/j.neurobiolaging.2025.01.006","url":null,"abstract":"<div><div>Age-related differences in fluid cognition have been associated with both the merging of functional brain networks, defined from resting-state functional magnetic resonance imaging (rsfMRI), and with elevated cortical iron, assessed by quantitative susceptibility mapping (QSM). Limited information is available, however, regarding the depthwise profile of cortical iron and its potential relation to functional connectivity. Here, using an adult lifespan sample (<em>n</em> = 138; 18–80 years), we assessed relations among graph theoretical measures of functional connectivity, column-based depthwise measures of cortical iron, and fluid cognition (i.e., tests of memory, perceptual-motor speed, executive function). Increased age was related both to less segregated functional networks and to increased cortical iron, especially for superficial depths. Functional network segregation mediated age-related differences in memory, whereas depthwise iron mediated age-related differences in general fluid cognition. Lastly, higher mean parietal iron predicted lower network segregation for adults younger than 45 years of age. These findings suggest that functional connectivity and depthwise cortical iron have distinct, complementary roles in the relation between age and fluid cognition in healthy adults.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"148 ","pages":"Pages 27-40"},"PeriodicalIF":3.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-26DOI: 10.1016/j.neurobiolaging.2025.01.005
Seyed Hani Hojjati , Tracy A. Butler , Mony de Leon , Ajay Gupta , Siddharth Nayak , José A. Luchsinger , Qolamreza R. Razlighi , Gloria C. Chiang
Alzheimer's disease (AD) is pathologically marked by tau tangles and beta-amyloid (Aβ) plaques. It has been hypothesized that Aβ facilitates spread of tau outside of the medial temporal lobe (MTL), but exact mechanism of this facilitation remains unclear. We aimed to test the hypothesis that abnormal Aβ induces an increase in inter-network functional connectivity, which in turn induces early-stage tau elevation in limbic network. Our study used 18F-Florbetaben Aβ positron emission tomography (PET), 18F-MK6240 tau-PET, and resting-state functional magnetic resonance imaging (rs-fMRI) from 489 healthy unimpaired older adults, including 46 with longitudinal data. We found significant correlations between tau in limbic network and Aβ in distinct functional networks. We then demonstrated that Aβ+ /Tau- participants exhibited elevated inter-network functional connectivity of the limbic network. Finally, our longitudinal results showed that annual increases in inter-network functional connectivity between limbic network and default mode and control networks were linked to annual tau elevation in limbic network, primarily modulated by Aβ+ individuals. Understanding this early brain alteration in response to pathologies could guide treatments early in disease course.
{"title":"Inter-network functional connectivity increases by beta-amyloid and may facilitate the early stage of tau accumulation","authors":"Seyed Hani Hojjati , Tracy A. Butler , Mony de Leon , Ajay Gupta , Siddharth Nayak , José A. Luchsinger , Qolamreza R. Razlighi , Gloria C. Chiang","doi":"10.1016/j.neurobiolaging.2025.01.005","DOIUrl":"10.1016/j.neurobiolaging.2025.01.005","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is pathologically marked by tau tangles and beta-amyloid (Aβ) plaques. It has been hypothesized that Aβ facilitates spread of tau outside of the medial temporal lobe (MTL), but exact mechanism of this facilitation remains unclear. We aimed to test the hypothesis that abnormal Aβ induces an increase in inter-network functional connectivity, which in turn induces early-stage tau elevation in limbic network. Our study used 18F-Florbetaben Aβ positron emission tomography (PET), 18F-MK6240 tau-PET, and resting-state functional magnetic resonance imaging (rs-fMRI) from 489 healthy unimpaired older adults, including 46 with longitudinal data. We found significant correlations between tau in limbic network and Aβ in distinct functional networks. We then demonstrated that Aβ+ /Tau- participants exhibited elevated inter-network functional connectivity of the limbic network. Finally, our longitudinal results showed that annual increases in inter-network functional connectivity between limbic network and default mode and control networks were linked to annual tau elevation in limbic network, primarily modulated by Aβ+ individuals. Understanding this early brain alteration in response to pathologies could guide treatments early in disease course.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"148 ","pages":"Pages 16-26"},"PeriodicalIF":3.7,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-22DOI: 10.1016/j.neurobiolaging.2025.01.004
Håkon Grydeland , Markus H. Sneve , James M. Roe , Liisa Raud , Hedda T. Ness , Line Folvik , Inge Amlien , Oliver M. Geier , Øystein Sørensen , Didac Vidal-Piñeiro , Kristine B. Walhovd , Anders M. Fjell
Lower episodic memory capability, as seen in development and aging compared with younger adulthood, may partly depend on lower brain network segregation. Here, our objective was twofold: (1) test this hypothesis using within- and between-network functional connectivity (FC) during episodic memory encoding and retrieval, in two independent samples (n = 734, age 7–82 years). (2) Assess associations with age and the ability to predict memory comparing task-general FC and memory-modulated FC. In a multiverse-inspired approach, we performed tests across multiple analytic choices. Results showed that relationships differed based on these analytic choices and were mainly present in the largest dataset,. Significant relationships indicated that (i) memory-modulated FC predicted memory performance and associated with memory in an age-invariant manner. (ii) In line with the so-called neural dedifferentiation view, task-general FC showed lower segregation with higher age in adults which was associated with worse memory performance. In development, although there were only weak signs of a neural differentiation, that is, gradually higher segregation with higher age, we observed similar lower segregation-worse memory relationships. This age-invariant relationships between FC and episodic memory suggest that network segregation is pivotal for memory across the healthy lifespan.
{"title":"Network segregation during episodic memory shows age-invariant relations with memory performance from 7 to 82 years","authors":"Håkon Grydeland , Markus H. Sneve , James M. Roe , Liisa Raud , Hedda T. Ness , Line Folvik , Inge Amlien , Oliver M. Geier , Øystein Sørensen , Didac Vidal-Piñeiro , Kristine B. Walhovd , Anders M. Fjell","doi":"10.1016/j.neurobiolaging.2025.01.004","DOIUrl":"10.1016/j.neurobiolaging.2025.01.004","url":null,"abstract":"<div><div>Lower episodic memory capability, as seen in development and aging compared with younger adulthood, may partly depend on lower brain network segregation. Here, our objective was twofold: (1) test this hypothesis using within- and between-network functional connectivity (FC) during episodic memory encoding and retrieval, in two independent samples (n = 734, age 7–82 years). (2) Assess associations with age and the ability to predict memory comparing task-general FC and memory-modulated FC. In a multiverse-inspired approach, we performed tests across multiple analytic choices. Results showed that relationships differed based on these analytic choices and were mainly present in the largest dataset,. Significant relationships indicated that (i) memory-modulated FC predicted memory performance and associated with memory in an age-invariant manner. (ii) In line with the so-called neural dedifferentiation view, task-general FC showed lower segregation with higher age in adults which was associated with worse memory performance. In development, although there were only weak signs of a neural differentiation, that is, gradually higher segregation with higher age, we observed similar lower segregation-worse memory relationships. This age-invariant relationships between FC and episodic memory suggest that network segregation is pivotal for memory across the healthy lifespan.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"148 ","pages":"Pages 1-15"},"PeriodicalIF":3.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-15DOI: 10.1016/j.neurobiolaging.2025.01.003
Hilal Salim Said Al Shamsi , Samantha L. Gardener , Stephanie R. Rainey-Smith , Steve Pedrini , Hamid R. Sohrabi , Kevin Taddei , Colin L. Masters , Ralph N. Martins , W.M.A.D. Binosha Fernando , for the AIBL research group
Associations between mental health, diet, and risk of Alzheimer’s disease highlight the need to investigate whether dietary patterns moderate the relationship between symptoms of depression and anxiety, and neurodegeneration-related blood-based biomarkers. Cognitively unimpaired participants (n = 89) were included from the Australian Imaging, Biomarkers and Lifestyle study (mean age 75.37; 44 % male). Participants provided dietary, depressive and anxiety symptom data, and had measurement of blood-based biomarkers. Dietary pattern scores (Mediterranean diet (MeDi), Dietary Approaches to Stop Hypertension diet (DASH), and Western diet) were generated. Moderation and simple slope analyses were employed. In males with mean and below mean MeDi adherence, depressive symptoms were associated with higher neurofilament light (NfL) levels. In Apolipoprotein E ε4 non-carriers with lower than mean and mean MeDi adherence, depressive symptoms were associated with higher NfL and Aβ40 levels. No associations were observed between DASH and Western diets and neurodegeneration-related biomarkers. MeDi adherence is potentially a moderator of the relationship between depressive symptoms and neurodegeneration-related blood-based biomarkers, with sex- and genotype-specific approaches important to consider within this relationship.
{"title":"The moderating effect of diet on the relationship between depressive symptoms and Alzheimer’s disease-related blood-based biomarkers","authors":"Hilal Salim Said Al Shamsi , Samantha L. Gardener , Stephanie R. Rainey-Smith , Steve Pedrini , Hamid R. Sohrabi , Kevin Taddei , Colin L. Masters , Ralph N. Martins , W.M.A.D. Binosha Fernando , for the AIBL research group","doi":"10.1016/j.neurobiolaging.2025.01.003","DOIUrl":"10.1016/j.neurobiolaging.2025.01.003","url":null,"abstract":"<div><div>Associations between mental health, diet, and risk of Alzheimer’s disease highlight the need to investigate whether dietary patterns moderate the relationship between symptoms of depression and anxiety, and neurodegeneration-related blood-based biomarkers. Cognitively unimpaired participants (n = 89) were included from the Australian Imaging, Biomarkers and Lifestyle study (mean age 75.37; 44 % male). Participants provided dietary, depressive and anxiety symptom data, and had measurement of blood-based biomarkers. Dietary pattern scores (Mediterranean diet (MeDi), Dietary Approaches to Stop Hypertension diet (DASH), and Western diet) were generated. Moderation and simple slope analyses were employed. In males with mean and below mean MeDi adherence, depressive symptoms were associated with higher neurofilament light (NfL) levels. In Apolipoprotein E ε4 non-carriers with lower than mean and mean MeDi adherence, depressive symptoms were associated with higher NfL and Aβ40 levels. No associations were observed between DASH and Western diets and neurodegeneration-related biomarkers. MeDi adherence is potentially a moderator of the relationship between depressive symptoms and neurodegeneration-related blood-based biomarkers, with sex- and genotype-specific approaches important to consider within this relationship.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"Pages 213-222"},"PeriodicalIF":3.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1016/j.neurobiolaging.2025.01.001
KowsalyaDevi Pavuluri , John Huston III , Richard L. Ehman , Armando Manduca , Prashanthi Vemuri , Clifford R. Jack Jr. , Matthew L. Senjem , Matthew C. Murphy
Age-related cognitive decline is a complex phenomenon that is influenced by various neurobiological processes at the molecular, cellular, and tissue levels. The extent of this decline varies between individuals and the underlying determinants of these differences are not fully understood. Two of the most prominent signs of cognitive decline in aging are the deterioration of episodic memory, which is a hallmark of Alzheimer's disease (AD), and the nearly always accompanying atrophy of the medial temporal lobe. Both cross-sectional and longitudinal studies have consistently demonstrated the strong relationship between these two, however, recent advanced imaging techniques have shown promise for predicting cognitive decline earlier than atrophy measures. In this study, we investigate the value of brain biomechanical properties, specifically in the medial temporal lobe, for predicting global cognitive decline along the normal aging and AD spectrum. Our results indicate that the medial temporal stiffness significantly predicts future cognitive decline beyond that achieved by measures of atrophy and amyloidosis. Measures of brain biomechanical properties may provide valuable prognostic information to enable more efficient study design and evaluation of potential interventions.
{"title":"Brain mechanical properties predict longitudinal cognitive change in aging and Alzheimer's disease","authors":"KowsalyaDevi Pavuluri , John Huston III , Richard L. Ehman , Armando Manduca , Prashanthi Vemuri , Clifford R. Jack Jr. , Matthew L. Senjem , Matthew C. Murphy","doi":"10.1016/j.neurobiolaging.2025.01.001","DOIUrl":"10.1016/j.neurobiolaging.2025.01.001","url":null,"abstract":"<div><div>Age-related cognitive decline is a complex phenomenon that is influenced by various neurobiological processes at the molecular, cellular, and tissue levels. The extent of this decline varies between individuals and the underlying determinants of these differences are not fully understood. Two of the most prominent signs of cognitive decline in aging are the deterioration of episodic memory, which is a hallmark of Alzheimer's disease (AD), and the nearly always accompanying atrophy of the medial temporal lobe. Both cross-sectional and longitudinal studies have consistently demonstrated the strong relationship between these two, however, recent advanced imaging techniques have shown promise for predicting cognitive decline earlier than atrophy measures. In this study, we investigate the value of brain biomechanical properties, specifically in the medial temporal lobe, for predicting global cognitive decline along the normal aging and AD spectrum. Our results indicate that the medial temporal stiffness significantly predicts future cognitive decline beyond that achieved by measures of atrophy and amyloidosis. Measures of brain biomechanical properties may provide valuable prognostic information to enable more efficient study design and evaluation of potential interventions.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"Pages 203-212"},"PeriodicalIF":3.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1016/j.neurobiolaging.2025.01.002
David J. Madden
{"title":"Editorial: Guide for authors at Neurobiology of Aging","authors":"David J. Madden","doi":"10.1016/j.neurobiolaging.2025.01.002","DOIUrl":"10.1016/j.neurobiolaging.2025.01.002","url":null,"abstract":"","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"Pages 223-224"},"PeriodicalIF":3.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-07DOI: 10.1016/j.neurobiolaging.2024.12.012
Beatriz E. Padrela , Maksim Slivka , Markus H. Sneve , Pablo F. Garrido , Mathijs B.J. Dijsselhof , Tamara Hageman , Oliver Geier , Håkon Grydeland , Amnah Mahroo , Joost P.A. Kuijer , Simon Konstandin , Klaus Eickel , Frederik Barkhof , Matthias Günther , Kristine B. Walhovd , Anders M. Fjell , Henk J.M.M. Mutsaerts , Jan Petr
An emerging biomarker of blood-brain barrier (BBB) permeability is the time of exchange (Tex) of water from the blood to tissue, as measured by multi-echo arterial spin labeling (ASL) MRI. This new non-invasive sequence, already tested in mice, has recently been adapted to humans and optimized for clinical scanning time. In this study, we studied the normal variability of Tex over age and sex, which needs to be established as a reference for studying changes in neurological disease. We evaluated Tex, cerebral blood flow (CBF) and arterial transit time (ATT) in 209 healthy adults between 26 and 87 years, over age and sex, using general linear models in gray matter, white matter, and regionally in cerebral lobes. After QC, 194 participants were included in the main analysis, and the results demonstrated that both gray matter (GM) and white matter (WM) BBB permeability was higher with higher age (Tex lower by 0.47 ms per year in GM [p < 0.05], and by 0.49 ms in WM, for females; no significant for males), with the largest Tex difference in the frontal lobes (0.64 ms decrease per year, p = 0.011, population average). CBF was lower with higher age in the GM (-0.71 mL/min/100g per year, p < 0.001, for females; −0.31 mL/min/100g per year, p < 0.05, for males). When correcting Tex models for CBF and ATT, effect of age on Tex disappears in the GM, but not in the WM (β=-0.28, p = 0.08). The CBF findings of this study are in line with previous studies, demonstrating the validity of the new sequence. The BBB water permeability variation over age and sex described in this study provides a reference for future BBB research.
{"title":"Blood-brain barrier water permeability across the adult lifespan: A multi-echo ASL study","authors":"Beatriz E. Padrela , Maksim Slivka , Markus H. Sneve , Pablo F. Garrido , Mathijs B.J. Dijsselhof , Tamara Hageman , Oliver Geier , Håkon Grydeland , Amnah Mahroo , Joost P.A. Kuijer , Simon Konstandin , Klaus Eickel , Frederik Barkhof , Matthias Günther , Kristine B. Walhovd , Anders M. Fjell , Henk J.M.M. Mutsaerts , Jan Petr","doi":"10.1016/j.neurobiolaging.2024.12.012","DOIUrl":"10.1016/j.neurobiolaging.2024.12.012","url":null,"abstract":"<div><div>An emerging biomarker of blood-brain barrier (BBB) permeability is the time of exchange (Tex) of water from the blood to tissue, as measured by multi-echo arterial spin labeling (ASL) MRI. This new non-invasive sequence, already tested in mice, has recently been adapted to humans and optimized for clinical scanning time. In this study, we studied the normal variability of Tex over age and sex, which needs to be established as a reference for studying changes in neurological disease. We evaluated Tex, cerebral blood flow (CBF) and arterial transit time (ATT) in 209 healthy adults between 26 and 87 years, over age and sex, using general linear models in gray matter, white matter, and regionally in cerebral lobes. After QC, 194 participants were included in the main analysis, and the results demonstrated that both gray matter (GM) and white matter (WM) BBB permeability was higher with higher age (Tex lower by 0.47 ms per year in GM [p < 0.05], and by 0.49 ms in WM, for females; no significant for males), with the largest Tex difference in the frontal lobes (0.64 ms decrease per year, <em>p</em> = 0.011, population average). CBF was lower with higher age in the GM (-0.71 mL/min/100g per year, <em>p</em> < 0.001, for females; −0.31 mL/min/100g per year, <em>p</em> < 0.05, for males). When correcting Tex models for CBF and ATT, effect of age on Tex disappears in the GM, but not in the WM (<em>β</em>=-0.28, <em>p</em> = 0.08). The CBF findings of this study are in line with previous studies, demonstrating the validity of the new sequence. The BBB water permeability variation over age and sex described in this study provides a reference for future BBB research.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"Pages 176-186"},"PeriodicalIF":3.7,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-05DOI: 10.1016/j.neurobiolaging.2024.12.007
Indira C. Turney , Ashley C. Steinkrauss , Rebecca L. Wagner , Jordan D. Chamberlain , John T. West , Jonathan G. Hakun , Lesley A. Ross , Brenda A. Kirchhoff , Nancy A. Dennis
The growing population of older adults emphasizes the need to develop interventions that prevent or delay some of the cognitive decline that accompanies aging. In particular, as memory impairment is the foremost cognitive deficit affecting older adults, it is vital to develop interventions that improve memory function. This study addressed the problem of false memories in aging by training older adults to use details of past events during memory retrieval to distinguish targets from related lures. We examined the neural basis of a retrieval-based monitoring strategy by assessing changes in univariate BOLD activity and discriminability of targets and lures pre and post training. Results showed training-related decreases in false memory rates with no alterations to hit rates. Both training and practice were associated with altered recruitment of a frontoparietal monitoring network as well as benefits to neural discriminability within network regions. Participants with lower baseline neural discriminability between target and lure items exhibited the largest changes in neural discriminability. Collectively, our results highlight the benefits of training for reductions of false memories in aging. They also provide an understanding of the neural mechanisms that support these reductions.
{"title":"Neural effects of memory training to reduce false memories in older adults: Univariate and multivariate analyses","authors":"Indira C. Turney , Ashley C. Steinkrauss , Rebecca L. Wagner , Jordan D. Chamberlain , John T. West , Jonathan G. Hakun , Lesley A. Ross , Brenda A. Kirchhoff , Nancy A. Dennis","doi":"10.1016/j.neurobiolaging.2024.12.007","DOIUrl":"10.1016/j.neurobiolaging.2024.12.007","url":null,"abstract":"<div><div>The growing population of older adults emphasizes the need to develop interventions that prevent or delay some of the cognitive decline that accompanies aging. In particular, as memory impairment is the foremost cognitive deficit affecting older adults, it is vital to develop interventions that improve memory function. This study addressed the problem of false memories in aging by training older adults to use details of past events during memory retrieval to distinguish targets from related lures. We examined the neural basis of a retrieval-based monitoring strategy by assessing changes in univariate BOLD activity and discriminability of targets and lures pre and post training. Results showed training-related decreases in false memory rates with no alterations to hit rates. Both training and practice were associated with altered recruitment of a frontoparietal monitoring network as well as benefits to neural discriminability within network regions. Participants with lower baseline neural discriminability between target and lure items exhibited the largest changes in neural discriminability. Collectively, our results highlight the benefits of training for reductions of false memories in aging. They also provide an understanding of the neural mechanisms that support these reductions.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"Pages 187-202"},"PeriodicalIF":3.7,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-27DOI: 10.1016/j.neurobiolaging.2024.12.011
Ambereen Kidwai, Mingzhu Hou, Marianne de Chastelaine, Michael D. Rugg
The present study examines whether structural and functional variability in medial temporal lobe (MTL) neocortical regions correlate with individual differences in episodic memory and longitudinal memory change in cognitively healthy older adults. To address this question, older adults were administered a battery of neuropsychological tests on three occasions: the second occasion one month after the first test session, and a third session three years later. Structural and functional MRI data were acquired between the first two sessions and included an in-scanner associative recognition procedure enabling estimation of MTL encoding and recollection fMRI BOLD effects. Encoding effects in parahippocampal cortex correlated with associative recognition performance and baseline cognitive ability. Recollection effects in entorhinal cortex correlated with associative recognition performance and predicted memory change over the three-year follow-up interval, an association that remained after controlling for chronological age and entorhinal cortical volume. These findings suggest that entorhinal recollection effects may be indicative of the future functional integrity of the region and, hence, its capacity to support future memory performance.
{"title":"Recollection-related fMRI effects in entorhinal cortex predict longitudinal memory change in healthy older adults","authors":"Ambereen Kidwai, Mingzhu Hou, Marianne de Chastelaine, Michael D. Rugg","doi":"10.1016/j.neurobiolaging.2024.12.011","DOIUrl":"10.1016/j.neurobiolaging.2024.12.011","url":null,"abstract":"<div><div>The present study examines whether structural and functional variability in medial temporal lobe (MTL) neocortical regions correlate with individual differences in episodic memory and longitudinal memory change in cognitively healthy older adults. To address this question, older adults were administered a battery of neuropsychological tests on three occasions: the second occasion one month after the first test session, and a third session three years later. Structural and functional MRI data were acquired between the first two sessions and included an in-scanner associative recognition procedure enabling estimation of MTL encoding and recollection fMRI BOLD effects. Encoding effects in parahippocampal cortex correlated with associative recognition performance and baseline cognitive ability. Recollection effects in entorhinal cortex correlated with associative recognition performance and predicted memory change over the three-year follow-up interval, an association that remained after controlling for chronological age and entorhinal cortical volume. These findings suggest that entorhinal recollection effects may be indicative of the future functional integrity of the region and, hence, its capacity to support future memory performance.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"Pages 150-162"},"PeriodicalIF":3.7,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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