首页 > 最新文献

Neurology International最新文献

英文 中文
Contrasting Effects of an Atherogenic Diet and High-Protein/Unsaturated Fatty Acids Diet on the Accelerated Aging Mouse Model SAMP8 Phenotype. 致动脉粥样硬化饮食和高蛋白/不饱和脂肪酸饮食对加速衰老模型 SAMP8 表型的不同影响
IF 3.2 Q2 CLINICAL NEUROLOGY Pub Date : 2024-09-23 DOI: 10.3390/neurolint16050080
Jesús Llanquinao, Claudia Jara, Daniela Cortés-Díaz, Bredford Kerr, Cheril Tapia-Rojas

Background/Objectives: Aging has been extensively studied, with a growing interest in memory impairment by a neurobiological approach. Mitochondrial dysfunction is a hallmark of aging, contributing to the aging phenotype; therefore, mitochondrial interventions seem fundamental. The diet is a physiological approximation for modifying mitochondria, which could impact the age-related phenotype. Methods: We studied two diets with low-carbohydrate and high-fat compositions, differing in the amount of protein and the fat type disposable-the atherogenic diet Cocoa (high protein/high saturated fat/high cholesterol) and the South Beach diet (very high-protein/high-unsaturated fat)-on oxidative stress, mitochondrial state, and hippocampus-dependent memory in 3-month-old Senescence-Accelerated Mouse Model (SAMP8) seed over 3 months to determine their pro- or anti-aging effects. Results: Despite its bad reputation, the Cocoa diet reduces the reactive oxygen species (ROS) content without impacting the energy state and hippocampus-dependent spatial acuity. In contrast to the beneficial impact proposed for the South Beach diet, it induced a pro-aging phenotype, increasing oxidative damage and the levels of NR2B subunit of the NMDA, impairing energy and spatial acuity. Surprisingly, despite the negative changes observed with both diets, this led to subtle memory impairment, suggesting the activation of compensatory mechanisms preventing more severe cognitive decline. Conclusions: Our results demonstrated that diets usually considered good could be detrimental to the onset of aging. Also, probably due to the brain plasticity of non-aged animals, they compensate for the damage, preventing a more aggravated phenotype. Nevertheless, these silent changes could predispose or increase the risk of suffering pathologies at advanced age.

背景/目的:人们对衰老进行了广泛的研究,并越来越关注通过神经生物学方法对记忆损伤进行研究。线粒体功能障碍是衰老的一个标志,也是衰老表型的一个因素;因此,线粒体干预似乎至关重要。饮食是改变线粒体的生理学近似方法,可影响与年龄相关的表型。研究方法我们研究了两种由低碳水化合物和高脂肪组成的膳食,它们在蛋白质量和一次性脂肪类型上有所不同--致动脉粥样硬化膳食可可(高蛋白/高饱和脂肪/高胆固醇)和南海滩膳食(极高蛋白/高不饱和脂肪)--这两种膳食对 3 个月大的衰老加速小鼠模型(SAMP8)种子的氧化应激、线粒体状态和海马依赖性记忆的影响,为期 3 个月,以确定它们的促进或抗衰老作用。研究结果尽管可可饮食名声不好,但它能减少活性氧(ROS)含量,而不会影响能量状态和依赖海马的空间敏锐度。与 "南海滩饮食 "的有益影响相反,它却诱导了一种促衰老表型,增加了氧化损伤和 NMDA 的 NR2B 亚基水平,损害了能量和空间敏锐度。令人惊讶的是,尽管这两种饮食都出现了负面变化,但却导致了细微的记忆损伤,这表明代偿机制被激活,防止了更严重的认知能力下降。结论我们的研究结果表明,通常被认为是好的饮食可能对衰老的发生不利。此外,可能是由于非老龄动物大脑的可塑性,它们能补偿损伤,防止出现更严重的表型。然而,这些无声的变化可能会导致或增加高龄时出现病变的风险。
{"title":"Contrasting Effects of an Atherogenic Diet and High-Protein/Unsaturated Fatty Acids Diet on the Accelerated Aging Mouse Model SAMP8 Phenotype.","authors":"Jesús Llanquinao, Claudia Jara, Daniela Cortés-Díaz, Bredford Kerr, Cheril Tapia-Rojas","doi":"10.3390/neurolint16050080","DOIUrl":"https://doi.org/10.3390/neurolint16050080","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Aging has been extensively studied, with a growing interest in memory impairment by a neurobiological approach. Mitochondrial dysfunction is a hallmark of aging, contributing to the aging phenotype; therefore, mitochondrial interventions seem fundamental. The diet is a physiological approximation for modifying mitochondria, which could impact the age-related phenotype. <b>Methods:</b> We studied two diets with low-carbohydrate and high-fat compositions, differing in the amount of protein and the fat type disposable-the atherogenic diet Cocoa (high protein/high saturated fat/high cholesterol) and the South Beach diet (very high-protein/high-unsaturated fat)-on oxidative stress, mitochondrial state, and hippocampus-dependent memory in 3-month-old Senescence-Accelerated Mouse Model (SAMP8) seed over 3 months to determine their pro- or anti-aging effects. <b>Results:</b> Despite its bad reputation, the Cocoa diet reduces the reactive oxygen species (ROS) content without impacting the energy state and hippocampus-dependent spatial acuity. In contrast to the beneficial impact proposed for the South Beach diet, it induced a pro-aging phenotype, increasing oxidative damage and the levels of NR2B subunit of the NMDA, impairing energy and spatial acuity. Surprisingly, despite the negative changes observed with both diets, this led to subtle memory impairment, suggesting the activation of compensatory mechanisms preventing more severe cognitive decline. <b>Conclusions:</b> Our results demonstrated that diets usually considered good could be detrimental to the onset of aging. Also, probably due to the brain plasticity of non-aged animals, they compensate for the damage, preventing a more aggravated phenotype. Nevertheless, these silent changes could predispose or increase the risk of suffering pathologies at advanced age.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Systematic Review of Sporadic Creutzfeldt-Jakob Disease: Pathogenesis, Diagnosis, and Therapeutic Attempts. 散发性克雅氏病的系统回顾:发病机制、诊断和治疗尝试。
IF 3.2 Q2 CLINICAL NEUROLOGY Pub Date : 2024-09-20 DOI: 10.3390/neurolint16050079
Maria Carolina Jurcau, Anamaria Jurcau, Razvan Gabriel Diaconu, Vlad Octavian Hogea, Vharoon Sharma Nunkoo

Creutzfeldt-Jakob disease is a rare neurodegenerative and invariably fatal disease with a fulminant course once the first clinical symptoms emerge. Its incidence appears to be rising, although the increasing figures may be related to the improved diagnostic tools. Due to the highly variable clinical picture at onset, many specialty physicians should be aware of this disease and refer the patient to a neurologist for complete evaluation. The diagnostic criteria have been changed based on the considerable progress made in research on the pathogenesis and on the identification of reliable biomarkers. Moreover, accumulated knowledge on pathogenesis led to the identification of a series of possible therapeutic targets, although, given the low incidence and very rapid course, the evaluation of safety and efficacy of these therapeutic strategies is challenging.

克雅氏病是一种罕见的神经退行性疾病,一旦出现最初的临床症状,其病程必然是致命的。该病的发病率似乎正在上升,尽管数字的上升可能与诊断工具的改进有关。由于发病时的临床表现千变万化,许多专科医生都应了解这种疾病,并将患者转诊至神经科医生进行全面评估。随着发病机制研究的深入和可靠生物标志物的确定,诊断标准也发生了变化。此外,对发病机理的知识积累还导致确定了一系列可能的治疗靶点,不过,由于发病率低且病程非常迅速,对这些治疗策略的安全性和有效性进行评估具有挑战性。
{"title":"A Systematic Review of Sporadic Creutzfeldt-Jakob Disease: Pathogenesis, Diagnosis, and Therapeutic Attempts.","authors":"Maria Carolina Jurcau, Anamaria Jurcau, Razvan Gabriel Diaconu, Vlad Octavian Hogea, Vharoon Sharma Nunkoo","doi":"10.3390/neurolint16050079","DOIUrl":"10.3390/neurolint16050079","url":null,"abstract":"<p><p>Creutzfeldt-Jakob disease is a rare neurodegenerative and invariably fatal disease with a fulminant course once the first clinical symptoms emerge. Its incidence appears to be rising, although the increasing figures may be related to the improved diagnostic tools. Due to the highly variable clinical picture at onset, many specialty physicians should be aware of this disease and refer the patient to a neurologist for complete evaluation. The diagnostic criteria have been changed based on the considerable progress made in research on the pathogenesis and on the identification of reliable biomarkers. Moreover, accumulated knowledge on pathogenesis led to the identification of a series of possible therapeutic targets, although, given the low incidence and very rapid course, the evaluation of safety and efficacy of these therapeutic strategies is challenging.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcome Prediction by Diffusion Tensor Imaging (DTI) in Patients with Traumatic Injuries of the Median Nerve. 通过弥散张量成像 (DTI) 预测正中神经外伤患者的预后。
IF 3.2 Q2 CLINICAL NEUROLOGY Pub Date : 2024-09-19 DOI: 10.3390/neurolint16050078
Théa Voser, Manuel Martin, Issiaka Muriset, Michaela Winkler, Jean-Baptiste Ledoux, Yasser Alemán-Gómez, Sébastien Durand

Background/Objectives: The accurate quantification of peripheral nerve axonal regeneration after injury is critically important. Current strategies are limited to detecting early reinnervation. DTI is an MRI modality permitting the assessment of fractional anisotropy, which increases with axonal regeneration. The aim of this pilot study is to evaluate DTI as a potential predictive factor of clinical outcome after median nerve section and microsurgical repair. Methods: We included 10 patients with a complete section of the median nerve, who underwent microsurgical repair up to 7 days after injury. The follow-up period was 1 year, including the current strategy with clinical visits, the Rosén-Lundborg score and electroneuromyography. Additionally, DTI MRI of the injured wrist was planned 1, 3 and 12 months post-operatively and once for the contralateral wrist. Results: The interobserver reliability of DTI measures was almost perfect (ICC 0.802). We report an early statistically significant increase in the fractional anisotropy value after median nerve repair, especially in the region located distal to the suture. Meanwhile, Rosén-Lundborg score gradually increased between the third and sixth month, and continued to increase between the sixth and twelfth month. Conclusions: DTI outcomes three months post-operation could offer greater predictability compared to current strategies. This would enable faster decision-making regarding the need for a potential re-operation in cases of inadequate early reinnervation.

背景/目的:准确量化损伤后的周围神经轴突再生至关重要。目前的策略仅限于检测早期神经再支配。DTI 是一种磁共振成像模式,可评估随轴突再生而增加的分数各向异性。本试验研究旨在评估 DTI 作为正中神经切片和显微手术修复后临床结果的潜在预测因素。研究方法我们纳入了 10 名正中神经完全断裂的患者,他们在受伤后 7 天内接受了显微手术修复。随访期为 1 年,包括临床访视、Rosén-Lundborg 评分和电神经肌电图等现行策略。此外,还计划在术后 1、3 和 12 个月对受伤的手腕进行 DTI MRI 检查,并对对侧手腕进行一次检查。结果:DTI 测量的观察者间可靠性几乎完美(ICC 0.802)。我们报告称,正中神经修复术后,尤其是缝合远端区域的分数各向异性值在早期出现了统计学意义上的显著增加。同时,Rosén-Lundborg 评分在第三个月至第六个月期间逐渐上升,并在第六个月至第十二个月期间持续上升。结论与目前的策略相比,术后三个月的 DTI 结果可提供更高的可预测性。这将有助于在早期神经支配不足的情况下更快地决定是否需要再次手术。
{"title":"Outcome Prediction by Diffusion Tensor Imaging (DTI) in Patients with Traumatic Injuries of the Median Nerve.","authors":"Théa Voser, Manuel Martin, Issiaka Muriset, Michaela Winkler, Jean-Baptiste Ledoux, Yasser Alemán-Gómez, Sébastien Durand","doi":"10.3390/neurolint16050078","DOIUrl":"10.3390/neurolint16050078","url":null,"abstract":"<p><p><b>Background/Objectives:</b> The accurate quantification of peripheral nerve axonal regeneration after injury is critically important. Current strategies are limited to detecting early reinnervation. DTI is an MRI modality permitting the assessment of fractional anisotropy, which increases with axonal regeneration. The aim of this pilot study is to evaluate DTI as a potential predictive factor of clinical outcome after median nerve section and microsurgical repair. <b>Methods:</b> We included 10 patients with a complete section of the median nerve, who underwent microsurgical repair up to 7 days after injury. The follow-up period was 1 year, including the current strategy with clinical visits, the Rosén-Lundborg score and electroneuromyography. Additionally, DTI MRI of the injured wrist was planned 1, 3 and 12 months post-operatively and once for the contralateral wrist. <b>Results:</b> The interobserver reliability of DTI measures was almost perfect (ICC 0.802). We report an early statistically significant increase in the fractional anisotropy value after median nerve repair, especially in the region located distal to the suture. Meanwhile, Rosén-Lundborg score gradually increased between the third and sixth month, and continued to increase between the sixth and twelfth month. <b>Conclusions:</b> DTI outcomes three months post-operation could offer greater predictability compared to current strategies. This would enable faster decision-making regarding the need for a potential re-operation in cases of inadequate early reinnervation.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anterograde Intramedullary Nailing without Bone Grafting for Humeral Shaft Nonunion Associated with Early Exploration of Secondary Radial Nerve Palsy: A Case Report. 无需植骨的前行髓内钉治疗伴有继发性桡神经麻痹的肱骨轴不连:病例报告。
IF 3.2 Q2 CLINICAL NEUROLOGY Pub Date : 2024-09-15 DOI: 10.3390/neurolint16050077
Dan Viorel Nistor, Răzvan Marian Melinte, Romana von Mengershausen

Background: Humeral shaft fractures are relatively common. Complications associated with this type of fracture and its treatment include nonunion and radial nerve palsy. Plate osteosynthesis with autologous bone grafting is considered the gold standard for treating nonunion. However, bone grafts might not always be necessary in cases of hypertrophic nonunion, and treatment should be tailored to the specific type and characteristics of the nonunion. The treatment of radial nerve palsy is debated, with some favoring expectant management based on the nerve's ability to regenerate, and others preferring early surgical exploration to prevent possible lasting nerve damage.

Methods: We present the case of a 46-year-old male patient with a six-year-old humeral shaft fracture resulting in hypertrophic nonunion. We treated the nonunion with anterograde intramedullary nailing without bone grafting. Postoperatively, the patient developed severe radial nerve palsy. After repeated electrophysiological studies, a decision was made to surgically explore the nerve 10 days after the nonunion surgery. The nerve was subsequently found to be intact and treated with neurolysis.

Results: Bony union was shown at six months after nonunion surgery. Four months after the nonunion surgery, the patient started to show clinical signs of nerve recovery, and at 12 months he achieved nearly full clinical recovery of radial nerve function.

Conclusions: Anterograde intramedullary nailing without autologous bone grafting may be considered an option for treating hypertrophic nonunion. The management of radial nerve palsy requires effective cooperation and communication between patient and physician. Further research is necessary to be able to better predict nerve recovery.

背景介绍肱骨轴骨折比较常见。与这类骨折及其治疗相关的并发症包括骨折不愈合和桡神经麻痹。钢板骨结合自体骨移植被认为是治疗骨不连的金标准。然而,在肥大性骨折的病例中并不一定需要植骨,治疗方法应根据骨折的具体类型和特征而定。对于桡神经麻痹的治疗方法还存在争议,有些人倾向于根据神经再生能力进行预期治疗,而另一些人则倾向于早期手术探查,以防止可能出现的持久性神经损伤:本病例是一名 46 岁的男性患者,其肱骨轴骨折已有 6 年之久,导致肱骨轴肥大性不愈合。我们采用前向髓内钉治疗,未进行植骨。术后,患者出现了严重的桡神经麻痹。经过反复的电生理研究,我们决定在骨不连手术后 10 天对神经进行手术探查。随后发现神经完好无损,并进行了神经切除术:结果:骨结合显示在骨不连手术后六个月。结果:骨结合在骨不连手术后 6 个月出现,在骨不连手术后 4 个月,患者开始出现神经恢复的临床症状,在 12 个月时,他的桡神经功能几乎完全恢复:结论:不进行自体骨移植的前行髓内钉可作为治疗肥大性桡神经离断的一种选择。桡神经麻痹的治疗需要患者和医生之间的有效合作与沟通。为了更好地预测神经恢复情况,有必要开展进一步研究。
{"title":"Anterograde Intramedullary Nailing without Bone Grafting for Humeral Shaft Nonunion Associated with Early Exploration of Secondary Radial Nerve Palsy: A Case Report.","authors":"Dan Viorel Nistor, Răzvan Marian Melinte, Romana von Mengershausen","doi":"10.3390/neurolint16050077","DOIUrl":"10.3390/neurolint16050077","url":null,"abstract":"<p><strong>Background: </strong>Humeral shaft fractures are relatively common. Complications associated with this type of fracture and its treatment include nonunion and radial nerve palsy. Plate osteosynthesis with autologous bone grafting is considered the gold standard for treating nonunion. However, bone grafts might not always be necessary in cases of hypertrophic nonunion, and treatment should be tailored to the specific type and characteristics of the nonunion. The treatment of radial nerve palsy is debated, with some favoring expectant management based on the nerve's ability to regenerate, and others preferring early surgical exploration to prevent possible lasting nerve damage.</p><p><strong>Methods: </strong>We present the case of a 46-year-old male patient with a six-year-old humeral shaft fracture resulting in hypertrophic nonunion. We treated the nonunion with anterograde intramedullary nailing without bone grafting. Postoperatively, the patient developed severe radial nerve palsy. After repeated electrophysiological studies, a decision was made to surgically explore the nerve 10 days after the nonunion surgery. The nerve was subsequently found to be intact and treated with neurolysis.</p><p><strong>Results: </strong>Bony union was shown at six months after nonunion surgery. Four months after the nonunion surgery, the patient started to show clinical signs of nerve recovery, and at 12 months he achieved nearly full clinical recovery of radial nerve function.</p><p><strong>Conclusions: </strong>Anterograde intramedullary nailing without autologous bone grafting may be considered an option for treating hypertrophic nonunion. The management of radial nerve palsy requires effective cooperation and communication between patient and physician. Further research is necessary to be able to better predict nerve recovery.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Romanian Translation and Cultural Adaptation of the Seizure Severity Questionnaire. 癫痫发作严重程度问卷的罗马尼亚语翻译和文化适应。
IF 3.2 Q2 CLINICAL NEUROLOGY Pub Date : 2024-09-13 DOI: 10.3390/neurolint16050076
Ionut-Horia Cioriceanu, Dan-Alexandru Constantin, Bianca Zamfirescu, Petru Cezar Podasca, Luigi Geo Marceanu, Liliana Rogozea

The aim of this study was to report the translation into Romanian of the Seizure Severity Questionnaire (SSQ), an instrument for the evaluation of the frequency and severity of epileptic seizures, and the results of applying it to a group of patients with epilepsy evaluated at a hospital in Romania.

Methods: Four translators were involved in obtaining conceptual analogies and the cultural importance of the translated notions. The final version was obtained for the Romanian population, with the same appearance as the original instrument. Sixty-seven patients with epilepsy completed the SSQ and the Patient-Weighted Quality of Life in Epilepsy Inventory-QOLIE-31-P.

Results: Females had a lower mean SSQ total score (TS) and perceived seizures less seriously than men. Patients with epilepsy with aura had a higher mean SSQ TS, with a more severe seizure perception, compared to those without aura. According to the frequency of seizures, patients with epilepsy with rare seizures had the lowest mean SSQ total score (TS) compared to those with frequent seizures. Patients who were on monotherapy had a less severe perception of epileptic seizures compared to those who were treated with two or more antiepileptic drugs. All QOLIE-31-P domains and TS correlated statistically significantly with the SSQ TS.

Conclusions: This study explored SSQ translation, evaluated preliminary results, and showed the correlation between seizure frequency and severity, clinical factors, and quality of life. This tool could be useful for measuring seizure severity in Romanian patients with epilepsy and conducting comparative studies.

癫痫发作严重程度问卷(SSQ)是一种评估癫痫发作频率和严重程度的工具,本研究旨在报告将该问卷翻译成罗马尼亚语的情况,以及将其应用于罗马尼亚一家医院评估的一组癫痫患者的结果:方法:四位译者参与了概念类比和翻译概念的文化重要性的研究。最终获得了适用于罗马尼亚人的版本,其外观与原始工具相同。67 名癫痫患者完成了 SSQ 和癫痫患者加权生活质量调查问卷-QOLIE-31-P:女性的 SSQ 平均总分(TS)低于男性,且认为癫痫发作的严重程度低于男性。与无先兆癫痫患者相比,有先兆癫痫患者的 SSQ TS 平均分更高,对癫痫发作的感知更严重。根据发作频率,与频繁发作的癫痫患者相比,罕见发作的癫痫患者的平均 SSQ 总分(TS)最低。与接受两种或两种以上抗癫痫药物治疗的患者相比,接受单一药物治疗的患者对癫痫发作的感知较轻。QOLIE-31-P的所有领域和TS与SSQ TS在统计学上有显著相关性:本研究探讨了 SSQ 的翻译,评估了初步结果,并显示了癫痫发作频率和严重程度、临床因素和生活质量之间的相关性。该工具可用于测量罗马尼亚癫痫患者的发作严重程度和进行比较研究。
{"title":"Romanian Translation and Cultural Adaptation of the Seizure Severity Questionnaire.","authors":"Ionut-Horia Cioriceanu, Dan-Alexandru Constantin, Bianca Zamfirescu, Petru Cezar Podasca, Luigi Geo Marceanu, Liliana Rogozea","doi":"10.3390/neurolint16050076","DOIUrl":"10.3390/neurolint16050076","url":null,"abstract":"<p><p>The aim of this study was to report the translation into Romanian of the Seizure Severity Questionnaire (SSQ), an instrument for the evaluation of the frequency and severity of epileptic seizures, and the results of applying it to a group of patients with epilepsy evaluated at a hospital in Romania.</p><p><strong>Methods: </strong>Four translators were involved in obtaining conceptual analogies and the cultural importance of the translated notions. The final version was obtained for the Romanian population, with the same appearance as the original instrument. Sixty-seven patients with epilepsy completed the SSQ and the Patient-Weighted Quality of Life in Epilepsy Inventory-QOLIE-31-P.</p><p><strong>Results: </strong>Females had a lower mean SSQ total score (TS) and perceived seizures less seriously than men. Patients with epilepsy with aura had a higher mean SSQ TS, with a more severe seizure perception, compared to those without aura. According to the frequency of seizures, patients with epilepsy with rare seizures had the lowest mean SSQ total score (TS) compared to those with frequent seizures. Patients who were on monotherapy had a less severe perception of epileptic seizures compared to those who were treated with two or more antiepileptic drugs. All QOLIE-31-P domains and TS correlated statistically significantly with the SSQ TS.</p><p><strong>Conclusions: </strong>This study explored SSQ translation, evaluated preliminary results, and showed the correlation between seizure frequency and severity, clinical factors, and quality of life. This tool could be useful for measuring seizure severity in Romanian patients with epilepsy and conducting comparative studies.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cerebrovascular Reactivity Assessed by Breath-Hold Functional MRI in Patients with Neurological Post-COVID-19 Syndrome-A Pilot Study. 通过屏气功能磁共振成像评估神经系统后 COVID-19 综合征患者的脑血管反应性--试点研究
IF 3.2 Q2 CLINICAL NEUROLOGY Pub Date : 2024-09-09 DOI: 10.3390/neurolint16050075
Leonie Zerweck, Uwe Klose, Annerose Mengel, Tobias Hoheisel, Melinda Eikemeier, Vivien Richter, Natalie Sophie Joos, Ulrike Ernemann, Benjamin Bender, Till-Karsten Hauser

Endothelial dysfunction represents a potential pathomechanism of neurological post-COVID-19 syndrome (PCS). A recent study demonstrated reduced cerebrovascular reactivity (CVR) in patients with PCS. The aim of this pilot study was to prospectively assess CVR in patients with PCS using breath-hold functional MRI (bh-fMRI). Fourteen patients with neurological PCS and leading symptoms of fatigue/memory issues/concentration disorder (PCSfmc), 11 patients with PCS and leading symptoms of myopathy/neuropathy (PCSmn), and 17 healthy controls underwent bh-fMRI. Signal change and time to peak (TTP) were assessed globally and in seven regions of interest and compared between the subgroups using one-way ANCOVA adjusting for age, time since infection, Fazekas score, and sex. No significant differences were observed. In PCS patients, the global CVR exhibited a slight, non-significant tendency to be lower compared to healthy controls (PCSfmc: 0.78 ± 0.11%, PCSmn: 0.84 ± 0.10% and 0.87 ± 0.07%). There was a non-significant trend towards lower global TTP values in the PCS subgroups than in the control group (PCSfmc: 26.41 ± 1.39 s, PCSmn: 26.32 ± 1.36 s versus 29.52 ± 0.93 s). Endothelial dysfunction does not seem to be the sole pathomechanism of neurological symptoms in PCS. Further studies in larger cohorts are required.

内皮功能障碍是导致神经性后 COVID-19 综合征(PCS)的潜在病理机制。最近的一项研究表明,PCS 患者的脑血管反应性(CVR)降低。本试验性研究旨在利用屏气功能磁共振成像(bh-fMRI)对 PCS 患者的 CVR 进行前瞻性评估。14名患有神经性PCS并伴有疲劳/记忆问题/注意力不集中等主要症状的患者(PCSfmc)、11名患有PCS并伴有肌病/神经病等主要症状的患者(PCSmn)和17名健康对照者接受了bh-fMRI检查。对信号变化和达到峰值的时间(TTP)进行了全面评估,并对七个感兴趣的区域进行了评估,通过单因素方差分析对年龄、感染后时间、法泽卡斯评分和性别进行了调整,比较了不同亚组之间的差异。未观察到明显差异。与健康对照组相比,PCS 患者的总体 CVR 呈轻微的、非显著性的降低趋势(PCSfmc:0.78 ± 0.11%;PCSmn:0.84 ± 0.10% 和 0.87 ± 0.07%)。与对照组相比(PCSfmc:26.41±1.39 秒;PCSmn:26.32±1.36 秒对 29.52±0.93 秒),PCS 亚组的总 TTP 值呈非显著性降低趋势。内皮功能障碍似乎不是 PCS 神经症状的唯一病理机制。还需要在更大的队列中进行进一步研究。
{"title":"Cerebrovascular Reactivity Assessed by Breath-Hold Functional MRI in Patients with Neurological Post-COVID-19 Syndrome-A Pilot Study.","authors":"Leonie Zerweck, Uwe Klose, Annerose Mengel, Tobias Hoheisel, Melinda Eikemeier, Vivien Richter, Natalie Sophie Joos, Ulrike Ernemann, Benjamin Bender, Till-Karsten Hauser","doi":"10.3390/neurolint16050075","DOIUrl":"10.3390/neurolint16050075","url":null,"abstract":"<p><p>Endothelial dysfunction represents a potential pathomechanism of neurological post-COVID-19 syndrome (PCS). A recent study demonstrated reduced cerebrovascular reactivity (CVR) in patients with PCS. The aim of this pilot study was to prospectively assess CVR in patients with PCS using breath-hold functional MRI (bh-fMRI). Fourteen patients with neurological PCS and leading symptoms of fatigue/memory issues/concentration disorder (PCS<sub>fmc</sub>), 11 patients with PCS and leading symptoms of myopathy/neuropathy (PCS<sub>mn</sub>), and 17 healthy controls underwent bh-fMRI. Signal change and time to peak (TTP) were assessed globally and in seven regions of interest and compared between the subgroups using one-way ANCOVA adjusting for age, time since infection, Fazekas score, and sex. No significant differences were observed. In PCS patients, the global CVR exhibited a slight, non-significant tendency to be lower compared to healthy controls (PCS<sub>fmc</sub>: 0.78 ± 0.11%, PCS<sub>mn</sub>: 0.84 ± 0.10% and 0.87 ± 0.07%). There was a non-significant trend towards lower global TTP values in the PCS subgroups than in the control group (PCS<sub>fmc</sub>: 26.41 ± 1.39 s, PCS<sub>mn</sub>: 26.32 ± 1.36 s versus 29.52 ± 0.93 s). Endothelial dysfunction does not seem to be the sole pathomechanism of neurological symptoms in PCS. Further studies in larger cohorts are required.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Clinical Manifestations, Risk Factors, Etiologies, and Outcomes of Adult Patients with Infectious Meningitis and Encephalitis: Single Center Experience. 传染性脑膜炎和脑炎成人患者的临床表现、风险因素、病因和预后:单中心经验
IF 3.2 Q2 CLINICAL NEUROLOGY Pub Date : 2024-09-05 DOI: 10.3390/neurolint16050073
Seraj Makkawi, Shatha Alqurashi, Wejdan Hubayni, Saleha Almahdawi, Sadeem Bahkali, Abeer Alharbi, Osama Khojah, Aisha Halawani, Israa Malli

(1) Background: Central nervous system (CNS) infections, including meningitis and encephalitis, are serious conditions which are associated with high morbidity and mortality. This study aims to identify the clinical manifestations, etiologies, and outcomes of meningitis and encephalitis in adult patients in Saudi Arabia, addressing the current gap in understanding these conditions within this population. (2) Methods: This is a single-center retrospective study which included all adult patients diagnosed with meningitis and encephalitis from March 2016 to May 2022. (3) Results: This study found that most cases of meningitis and encephalitis occurred due to unknown pathogens. Pretreatment with antibiotics prior to lumbar puncture (LP) was found in 71.2% of patients with meningitis. Altered mental status and seizures were common presenting symptoms among patients with encephalitis while altered mental status and fever were common among patients with meningitis. (4) Conclusions: Adherence to guidelines in treating meningitis and encephalitis and performing LPs in a timely manner are important. Establishing national biobanks with biological samples from patients suspected of having meningitis or encephalitis will significantly enhance our understanding of these conditions in Saudi Arabia.

(1) 背景:中枢神经系统(CNS)感染,包括脑膜炎和脑炎,是与高发病率和高死亡率相关的严重疾病。本研究旨在确定沙特阿拉伯成年患者脑膜炎和脑炎的临床表现、病因和预后,解决目前该人群对这些疾病认识不足的问题。(2) 方法:这是一项单中心回顾性研究,纳入了2016年3月至2022年5月期间确诊为脑膜炎和脑炎的所有成年患者。(3)结果:该研究发现,大多数脑膜炎和脑炎病例都是由未知病原体引起的。71.2%的脑膜炎患者在腰椎穿刺(LP)前接受了抗生素治疗。精神状态改变和癫痫发作是脑炎患者的常见症状,而精神状态改变和发烧则是脑膜炎患者的常见症状。(4) 结论:在治疗脑膜炎和脑炎时必须遵守指南,并及时进行 LP 检查。建立国家生物库,收集疑似脑膜炎或脑炎患者的生物样本,将大大提高我们对沙特阿拉伯这些疾病的了解。
{"title":"The Clinical Manifestations, Risk Factors, Etiologies, and Outcomes of Adult Patients with Infectious Meningitis and Encephalitis: Single Center Experience.","authors":"Seraj Makkawi, Shatha Alqurashi, Wejdan Hubayni, Saleha Almahdawi, Sadeem Bahkali, Abeer Alharbi, Osama Khojah, Aisha Halawani, Israa Malli","doi":"10.3390/neurolint16050073","DOIUrl":"10.3390/neurolint16050073","url":null,"abstract":"<p><p>(1) Background: Central nervous system (CNS) infections, including meningitis and encephalitis, are serious conditions which are associated with high morbidity and mortality. This study aims to identify the clinical manifestations, etiologies, and outcomes of meningitis and encephalitis in adult patients in Saudi Arabia, addressing the current gap in understanding these conditions within this population. (2) Methods: This is a single-center retrospective study which included all adult patients diagnosed with meningitis and encephalitis from March 2016 to May 2022. (3) Results: This study found that most cases of meningitis and encephalitis occurred due to unknown pathogens. Pretreatment with antibiotics prior to lumbar puncture (LP) was found in 71.2% of patients with meningitis. Altered mental status and seizures were common presenting symptoms among patients with encephalitis while altered mental status and fever were common among patients with meningitis. (4) Conclusions: Adherence to guidelines in treating meningitis and encephalitis and performing LPs in a timely manner are important. Establishing national biobanks with biological samples from patients suspected of having meningitis or encephalitis will significantly enhance our understanding of these conditions in Saudi Arabia.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluorescein Angiography for Monitoring Neural Blood Flow in Chronic Nerve Compression Neuropathy: Experimental Animal Models and Preliminary Clinical Observations. 荧光素血管造影用于监测慢性神经压迫性神经病的神经血流:实验动物模型和初步临床观察。
IF 3.2 Q2 CLINICAL NEUROLOGY Pub Date : 2024-09-05 DOI: 10.3390/neurolint16050074
Kosuke Saito, Mitsuhiro Okada, Takuya Yokoi, Shunpei Hama, Hiroaki Nakamura

Pathologies associated with neural blood disturbance have been reported in patients with chronic nerve compression (CNC) neuropathy. Fluorescein angiography (FAG) and laser Doppler flowmetry (LDF) are effective for real-time peripheral nerve blood flow assessment. However, their reliability in severe neuropathy models in large animals or clinical conditions remains unclear. Initially, we aim to apply FAG to two different CNC animal models and evaluate their characteristics in comparison with those of LDF. In FAG, we quantified the peak luminance at the compression site following fluorescein injection. Then, we positioned the LDF probe at the center of the compression site and recorded the blood flow. Subsequently, we analyzed whether the FAG characteristics obtained in this animal experiment were consistent with those of clinical studies in patients with severe carpal tunnel syndrome (CTS). In the CNC rat model, FAG and LDF effectively monitored reduced neural blood flow over time. We observed significant blood flow reduction using both techniques in a newly developed severe CNC rabbit model. Notably, FAG correlated strongly with the compound muscle action potential (CMAP) amplitude in electrodiagnostic findings, unlike LDF. As a next step, we performed FAG after open carpal tunnel release in clinical cases of CTS. FAG correlated significantly with preoperative CMAP amplitude. This indicates FAG's importance for assessing nerve blood flow during surgery, potentially improving diagnostic accuracy and surgical outcomes.

据报道,慢性神经压迫(CNC)神经病患者会出现与神经血液紊乱相关的病变。荧光素血管造影术(FAG)和激光多普勒血流测量仪(LDF)是实时评估周围神经血流的有效方法。然而,它们在大型动物严重神经病变模型或临床条件下的可靠性仍不明确。最初,我们的目标是将 FAG 应用于两种不同的 CNC 动物模型,并评估它们与 LDF 相比的特点。在 FAG 中,我们量化了注射荧光素后压迫部位的峰值亮度。然后,我们将 LDF 探头置于压迫部位的中心并记录血流。随后,我们分析了动物实验中获得的 FAG 特性是否与严重腕管综合征(CTS)患者的临床研究结果一致。在 CNC 大鼠模型中,FAG 和 LDF 可有效监测神经血流随时间推移而减少的情况。在新开发的严重腕管综合征兔模型中,我们使用这两种技术观察到血流量明显减少。值得注意的是,与 LDF 不同,FAG 与电诊断结果中的复合肌肉动作电位(CMAP)振幅密切相关。下一步,我们在 CTS 临床病例的腕管开放松解术后进行了 FAG。FAG 与术前 CMAP 振幅有明显相关性。这表明 FAG 在手术过程中评估神经血流的重要性,有可能提高诊断准确性和手术效果。
{"title":"Fluorescein Angiography for Monitoring Neural Blood Flow in Chronic Nerve Compression Neuropathy: Experimental Animal Models and Preliminary Clinical Observations.","authors":"Kosuke Saito, Mitsuhiro Okada, Takuya Yokoi, Shunpei Hama, Hiroaki Nakamura","doi":"10.3390/neurolint16050074","DOIUrl":"10.3390/neurolint16050074","url":null,"abstract":"<p><p>Pathologies associated with neural blood disturbance have been reported in patients with chronic nerve compression (CNC) neuropathy. Fluorescein angiography (FAG) and laser Doppler flowmetry (LDF) are effective for real-time peripheral nerve blood flow assessment. However, their reliability in severe neuropathy models in large animals or clinical conditions remains unclear. Initially, we aim to apply FAG to two different CNC animal models and evaluate their characteristics in comparison with those of LDF. In FAG, we quantified the peak luminance at the compression site following fluorescein injection. Then, we positioned the LDF probe at the center of the compression site and recorded the blood flow. Subsequently, we analyzed whether the FAG characteristics obtained in this animal experiment were consistent with those of clinical studies in patients with severe carpal tunnel syndrome (CTS). In the CNC rat model, FAG and LDF effectively monitored reduced neural blood flow over time. We observed significant blood flow reduction using both techniques in a newly developed severe CNC rabbit model. Notably, FAG correlated strongly with the compound muscle action potential (CMAP) amplitude in electrodiagnostic findings, unlike LDF. As a next step, we performed FAG after open carpal tunnel release in clinical cases of CTS. FAG correlated significantly with preoperative CMAP amplitude. This indicates FAG's importance for assessing nerve blood flow during surgery, potentially improving diagnostic accuracy and surgical outcomes.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transient Ipsilateral Hemineglect Following Brain Laser Ablation in Patient with Focal Cortical Dysplasia. 局灶性皮质发育不良患者脑激光消融术后的一过性同侧失血。
IF 3.2 Q2 CLINICAL NEUROLOGY Pub Date : 2024-09-03 DOI: 10.3390/neurolint16050072
Georgios Ntolkeras, Fatemeh Mohammadpour Touserkani, Michelle Y Chiu, Sanjay P Prabhu, Scellig Stone, Alexander Rotenberg

Sensory integration is the province of the parietal lobe. The non-dominant hemisphere is responsible for both body sides, while the dominant hemisphere is responsible for the contralateral hemi-body. Furthermore, the posterior cingulate cortex (PCC) participates in a network involved in spatial orientation, attention, and spatial and episodic memory. Laser interstitial thermotherapy (LiTT) is a minimally invasive surgery for focal drug-resistant epilepsy (DRE) that can target deeper brain regions, and thus, region-specific symptoms can emerge. Here, we present an 18-year-old right-handed male with focal DRE who experienced seizures characterized by sensations of déjà vu, staring spells, and language disruption. A comprehensive evaluation localized the seizure focus and revealed a probable focal cortical dysplasia (FCD) in the left posterior cingulate gyrus. The patient underwent uneventful LiTT of the identified lesion. Post-operatively, he developed transient ipsilateral spatial neglect and contralateral sensory loss, as well as acalculia. His sensory symptoms gradually improved after the surgery, and he remained seizure-free after the intervention for at least 10 months (until the time of this writing). This rare case of ipsilateral spatial and visual hemineglect post-LiTT in epilepsy underscores the importance of recognizing atypical neurosurgical outcomes and considering individual variations in brain anatomy and function. Understanding the dynamics of cortical connectivity and handedness, particularly in pediatric epilepsy, may be crucial in anticipating and managing neurocognitive effects following epilepsy surgery.

顶叶负责感觉统合。非优势半球负责身体两侧,优势半球负责对侧半身。此外,后扣带回皮层(PCC)参与了一个涉及空间定向、注意力、空间记忆和情节记忆的网络。激光间质热疗(LiTT)是一种治疗局灶性耐药性癫痫(DRE)的微创手术,它可以针对更深层的脑区,因此会出现特定区域的症状。在此,我们介绍了一名患有局灶性耐药性癫痫的 18 岁右撇子男性患者,他的癫痫发作以似曾相识的感觉、凝视咒语和语言障碍为特征。综合评估确定了发作病灶的位置,并发现左侧扣带回后部可能存在局灶性皮质发育不良(FCD)。患者顺利接受了已确定病灶的LTT手术。术后,他出现了短暂的同侧空间忽略和对侧感觉缺失以及计算障碍。术后,他的感觉症状逐渐改善,干预后至少 10 个月(直到本文撰写之时)没有癫痫发作。这一罕见的癫痫患者LiTT术后同侧空间和视觉偏盲病例强调了识别非典型神经外科手术结果以及考虑大脑解剖和功能个体差异的重要性。了解大脑皮层连接和手性的动态变化,尤其是小儿癫痫患者的手性,可能对预测和处理癫痫手术后的神经认知影响至关重要。
{"title":"Transient Ipsilateral Hemineglect Following Brain Laser Ablation in Patient with Focal Cortical Dysplasia.","authors":"Georgios Ntolkeras, Fatemeh Mohammadpour Touserkani, Michelle Y Chiu, Sanjay P Prabhu, Scellig Stone, Alexander Rotenberg","doi":"10.3390/neurolint16050072","DOIUrl":"10.3390/neurolint16050072","url":null,"abstract":"<p><p>Sensory integration is the province of the parietal lobe. The non-dominant hemisphere is responsible for both body sides, while the dominant hemisphere is responsible for the contralateral hemi-body. Furthermore, the posterior cingulate cortex (PCC) participates in a network involved in spatial orientation, attention, and spatial and episodic memory. Laser interstitial thermotherapy (LiTT) is a minimally invasive surgery for focal drug-resistant epilepsy (DRE) that can target deeper brain regions, and thus, region-specific symptoms can emerge. Here, we present an 18-year-old right-handed male with focal DRE who experienced seizures characterized by sensations of déjà vu, staring spells, and language disruption. A comprehensive evaluation localized the seizure focus and revealed a probable focal cortical dysplasia (FCD) in the left posterior cingulate gyrus. The patient underwent uneventful LiTT of the identified lesion. Post-operatively, he developed transient ipsilateral spatial neglect and contralateral sensory loss, as well as acalculia. His sensory symptoms gradually improved after the surgery, and he remained seizure-free after the intervention for at least 10 months (until the time of this writing). This rare case of ipsilateral spatial and visual hemineglect post-LiTT in epilepsy underscores the importance of recognizing atypical neurosurgical outcomes and considering individual variations in brain anatomy and function. Understanding the dynamics of cortical connectivity and handedness, particularly in pediatric epilepsy, may be crucial in anticipating and managing neurocognitive effects following epilepsy surgery.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantifying the Transition from Unconscious to Conscious Detection of Temporal Patterns in Vigilance Tasks: A Unique Adaptation of Mackworth's Clock Test. 量化警觉任务中从无意识到有意识检测时间模式的转变:麦克沃斯时钟测试的独特改编。
IF 3.2 Q2 CLINICAL NEUROLOGY Pub Date : 2024-08-31 DOI: 10.3390/neurolint16050071
Guaraci Lima de Morais, Tatiana Okubo Rocha Pinho, Leonardo Crespim, Osmar Pinto Neto

This study investigates the cognitive mechanisms underlying vigilance and pattern recognition using a novel adaptation of Mackworth's Clock Test. We aimed to quantify the time it takes for temporal patterns detected unconsciously through implicit learning to surface in the conscious mind within a dynamic vigilance task environment. Forty-eight participants detected random and non-disclosed rhythmic anomalous clock hand movements in this setting. Our results indicate significant variability in detection accuracy, reaction times, and the ability to recognize the hidden pattern among participants. Notably, 23% of all participants and 56% of those who consciously reported the pattern exhibited statistically lower reaction times indicative of knowledge of the pattern 40 s before conscious identification. These findings provide valuable insights into the transition from unconscious to conscious detection, highlighting the complexity of sustained attention and pattern recognition. The study's implications extend to designing training programs and tasks for high-stakes professions requiring prolonged vigilance. Future research should further explore the cognitive and neural correlates of these processes and the impact of task complexity on performance.

本研究通过对麦克沃斯时钟测试的新颖改编,研究了警觉性和模式识别的认知机制。我们的目的是量化在动态警觉任务环境中,通过内隐学习无意识检测到的时间模式在意识中浮现所需的时间。48 名参与者在这一环境中检测了随机和非公开的有节奏的异常时钟指针运动。我们的研究结果表明,参与者在检测准确性、反应时间和识别隐藏模式的能力方面存在很大差异。值得注意的是,在所有参与者中,有 23% 的人和 56% 的人在有意识地报告该模式时,其反应时间在统计学上较低,这表明他们在有意识地识别之前 40 秒就已经知道了该模式。这些发现为从无意识检测到有意识检测的过渡提供了宝贵的见解,突出了持续注意和模式识别的复杂性。这项研究对设计需要长时间警觉的高风险职业的培训计划和任务具有重要意义。未来的研究应进一步探索这些过程的认知和神经相关性,以及任务复杂性对表现的影响。
{"title":"Quantifying the Transition from Unconscious to Conscious Detection of Temporal Patterns in Vigilance Tasks: A Unique Adaptation of Mackworth's Clock Test.","authors":"Guaraci Lima de Morais, Tatiana Okubo Rocha Pinho, Leonardo Crespim, Osmar Pinto Neto","doi":"10.3390/neurolint16050071","DOIUrl":"10.3390/neurolint16050071","url":null,"abstract":"<p><p>This study investigates the cognitive mechanisms underlying vigilance and pattern recognition using a novel adaptation of Mackworth's Clock Test. We aimed to quantify the time it takes for temporal patterns detected unconsciously through implicit learning to surface in the conscious mind within a dynamic vigilance task environment. Forty-eight participants detected random and non-disclosed rhythmic anomalous clock hand movements in this setting. Our results indicate significant variability in detection accuracy, reaction times, and the ability to recognize the hidden pattern among participants. Notably, 23% of all participants and 56% of those who consciously reported the pattern exhibited statistically lower reaction times indicative of knowledge of the pattern 40 s before conscious identification. These findings provide valuable insights into the transition from unconscious to conscious detection, highlighting the complexity of sustained attention and pattern recognition. The study's implications extend to designing training programs and tasks for high-stakes professions requiring prolonged vigilance. Future research should further explore the cognitive and neural correlates of these processes and the impact of task complexity on performance.</p>","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Neurology International
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1