Pub Date : 2025-05-01Epub Date: 2025-06-17DOI: 10.1016/j.ntt.2025.107459
Emily Pitzer
{"title":"Identification of neurotoxicology (NT)/developmental neurotoxicology (DNT) adverse outcome pathways and key event linkages with in vitro DNT screening assays","authors":"Emily Pitzer","doi":"10.1016/j.ntt.2025.107459","DOIUrl":"10.1016/j.ntt.2025.107459","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107459"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-06-17DOI: 10.1016/j.ntt.2025.107486
Emily Pitzer, Tracey Beasley, Garyn Jung, Kathy McDaniel, William Padgett, Witold Winnik, David Herr
{"title":"Proteomic changes and pathway analysis of brain tissues following exposure to the glutamatergic excitotoxin, kainic acid in Long Evans rats","authors":"Emily Pitzer, Tracey Beasley, Garyn Jung, Kathy McDaniel, William Padgett, Witold Winnik, David Herr","doi":"10.1016/j.ntt.2025.107486","DOIUrl":"10.1016/j.ntt.2025.107486","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107486"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-06-17DOI: 10.1016/j.ntt.2025.107483
Lynn Singer , Elizabeth Schultheis , Jeffrey Albert , June-yung Kim , Sonia Minnes , Meeyoung Min
{"title":"Pathways from prenatal alcohol exposure to adult working memory deficit","authors":"Lynn Singer , Elizabeth Schultheis , Jeffrey Albert , June-yung Kim , Sonia Minnes , Meeyoung Min","doi":"10.1016/j.ntt.2025.107483","DOIUrl":"10.1016/j.ntt.2025.107483","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107483"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-03-24DOI: 10.1016/j.ntt.2025.107446
Nicolas Murgueitio , Margaret A. Sheridan , Michelle Shipkova , Amy G. Halberstadt , Patricia T. Garrett-Peters , Cathi B. Propper
Dimensional models of early adversity propose developmental mechanisms by which threat and deprivation confer risk for psychopathology. Exposure to violent environments may influence social information processing biases, and limited access to complex learning environments might be associated with general challenges in emotion recognition. We examined associations of adversity measured early in development (6–36 months) and emotion recognition in early (72 months) and middle (96 months) childhood in a sample of 92 mother-child dyads. Low cognitive stimulation negatively predicted early childhood emotion recognition (β = −0.32, p = .01). Moreover, experiences of intimate-partner violence were associated with anger bias, but not global emotion recognition, in early (β = 0.24, p = .01), and middle (β = 0.18, p = .04) childhood. This pattern suggests that while the lack of exposure to complex learning experiences might impact children's conceptual knowledge of emotions, children who experience violence show biases that facilitate threat detection.
早期逆境的维度模型提出了威胁和剥夺赋予精神病理风险的发展机制。暴露在暴力环境中可能会影响社会信息处理偏见,而进入复杂学习环境的机会有限可能与情绪识别方面的一般挑战有关。我们以92对母子为样本,研究了在发育早期(6-36个月)和童年早期(72个月)和中期(96个月)测量的逆境与情绪识别的关联。低认知刺激负向预测幼儿情绪识别(β = - 0.32, p = 0.01)。此外,在童年早期(β = 0.24, p = 0.01)和中期(β = 0.18, p = 0.04),亲密伴侣暴力的经历与愤怒偏见有关,但与整体情绪识别无关。这一模式表明,虽然缺乏接触复杂学习经验可能会影响儿童对情绪的概念性知识,但经历过暴力的儿童表现出有助于发现威胁的偏见。
{"title":"Developmental impacts of deprivation and threat on emotion recognition","authors":"Nicolas Murgueitio , Margaret A. Sheridan , Michelle Shipkova , Amy G. Halberstadt , Patricia T. Garrett-Peters , Cathi B. Propper","doi":"10.1016/j.ntt.2025.107446","DOIUrl":"10.1016/j.ntt.2025.107446","url":null,"abstract":"<div><div>Dimensional models of early adversity propose developmental mechanisms by which threat and deprivation confer risk for psychopathology. Exposure to violent environments may influence social information processing biases, and limited access to complex learning environments might be associated with general challenges in emotion recognition. We examined associations of adversity measured early in development (6–36 months) and emotion recognition in early (72 months) and middle (96 months) childhood in a sample of 92 mother-child dyads. Low cognitive stimulation negatively predicted early childhood emotion recognition (β = −0.32, <em>p =</em> .01). Moreover, experiences of intimate-partner violence were associated with anger bias, but not global emotion recognition, in early (β = 0.24, <em>p =</em> .01), and middle (β = 0.18, <em>p =</em> .04) childhood. This pattern suggests that while the lack of exposure to complex learning experiences might impact children's conceptual knowledge of emotions, children who experience violence show biases that facilitate threat detection.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107446"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-06-17DOI: 10.1016/j.ntt.2025.107475
Amanda L. Elmore
{"title":"Implications of abortion legislation on birth defects surveillance","authors":"Amanda L. Elmore","doi":"10.1016/j.ntt.2025.107475","DOIUrl":"10.1016/j.ntt.2025.107475","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107475"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-06-17DOI: 10.1016/j.ntt.2025.107461
Gregg Stanwood
{"title":"Reverse translation in animals and cell models: Methods to accelerate therapeutic development and mechanisms","authors":"Gregg Stanwood","doi":"10.1016/j.ntt.2025.107461","DOIUrl":"10.1016/j.ntt.2025.107461","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107461"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-06-17DOI: 10.1016/j.ntt.2025.107463
Sura Alwan
{"title":"Constellation of traits of disorders? Challenging our definition of autism as an adverse outcome","authors":"Sura Alwan","doi":"10.1016/j.ntt.2025.107463","DOIUrl":"10.1016/j.ntt.2025.107463","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107463"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-06-17DOI: 10.1016/j.ntt.2025.107464
Joseph Grzywacz
{"title":"Work & family: How a social scientist thinks about chemical and non-chemical toxicants","authors":"Joseph Grzywacz","doi":"10.1016/j.ntt.2025.107464","DOIUrl":"10.1016/j.ntt.2025.107464","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107464"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-06-17DOI: 10.1016/j.ntt.2025.107458
Natacha M. De Genna
{"title":"High times: The effects of prenatal cannabis exposure and next steps","authors":"Natacha M. De Genna","doi":"10.1016/j.ntt.2025.107458","DOIUrl":"10.1016/j.ntt.2025.107458","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107458"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}