Pub Date : 2026-02-19DOI: 10.1007/s10072-026-08864-1
Kangshuai Du, Yanxin Zhao, Zhenguo Liu
{"title":"Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and cognitive impairment in middle-aged and elderly Chinese population.","authors":"Kangshuai Du, Yanxin Zhao, Zhenguo Liu","doi":"10.1007/s10072-026-08864-1","DOIUrl":"10.1007/s10072-026-08864-1","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"274"},"PeriodicalIF":2.4,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-19DOI: 10.1007/s10072-026-08828-5
Giovanni Di Mauro, Maria Rosaria Bagnato, Francesca Bernocchi, Martina Gaia Di Donna, Maria Rita Di Ruzza, Mario Ferrante, Emanuele Saggese, Roberto De Simone
{"title":"Unusual brain MRI findings in botulism: a case report of brainstem DWI restriction and pathophysiological implications.","authors":"Giovanni Di Mauro, Maria Rosaria Bagnato, Francesca Bernocchi, Martina Gaia Di Donna, Maria Rita Di Ruzza, Mario Ferrante, Emanuele Saggese, Roberto De Simone","doi":"10.1007/s10072-026-08828-5","DOIUrl":"10.1007/s10072-026-08828-5","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"272"},"PeriodicalIF":2.4,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for Parkinson's disease (PD). The outcome of DBS varies from patient to patient.
Objectives: We investigated the preoperative changes in the midbrain to predict DBS outcomes.
Methods: Patients with PD who underwent bilateral STN-DBS at Juntendo University Hospital between June 2019 and October 2020 were included. We compared the Movement Disorders Society Unified Parkinson's Disease Rating Scale Part III score in the off state 3 months before and 1 year after surgery, and the difference in the score was defined as the motor outcome after DBS. Preoperative magnetic resonance images of the midbrain were evaluated using FreeSurfer and the One-Line Method.
Results: A total of 34 patients were enrolled. Multiple regression analysis with least squares indicated that the volume of the midbrain measured using FreeSurfer had no significance as an independent variable (p = 0.16), whereas the midbrain length evaluated using the One-Line Method had significance (p < 0.05) when the outcome of motor symptoms was set as the dependent variable.
Conclusions: We showed that midbrain size evaluated using the One-Line Method was a good predictor of the motor outcome after STN-DBS, but volume measured using FreeSurfer was not. The One-Line Method was considered to detect changes in size specifically in the midbrain tegmentum, which is associated with PD motor symptoms. Thus, we present a simple and useful method for predicting poor outcomes after STN-DBS treatment in patients with PD with disease progression.
{"title":"Midbrain length by the one-line method predicts motor outcome after deep brain stimulation in Parkinson's disease.","authors":"Hikaru Kamo, Wataru Sako, Genko Oyama, Akimitsu Suda, Masanobu Ito, Hirokazu Iwamuro, Atsushi Umemura, Taku Hatano, Koji Kamagata, Shigeki Aoki, Nobutaka Hattori","doi":"10.1007/s10072-026-08867-y","DOIUrl":"10.1007/s10072-026-08867-y","url":null,"abstract":"<p><strong>Background: </strong>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for Parkinson's disease (PD). The outcome of DBS varies from patient to patient.</p><p><strong>Objectives: </strong>We investigated the preoperative changes in the midbrain to predict DBS outcomes.</p><p><strong>Methods: </strong>Patients with PD who underwent bilateral STN-DBS at Juntendo University Hospital between June 2019 and October 2020 were included. We compared the Movement Disorders Society Unified Parkinson's Disease Rating Scale Part III score in the off state 3 months before and 1 year after surgery, and the difference in the score was defined as the motor outcome after DBS. Preoperative magnetic resonance images of the midbrain were evaluated using FreeSurfer and the One-Line Method.</p><p><strong>Results: </strong>A total of 34 patients were enrolled. Multiple regression analysis with least squares indicated that the volume of the midbrain measured using FreeSurfer had no significance as an independent variable (p = 0.16), whereas the midbrain length evaluated using the One-Line Method had significance (p < 0.05) when the outcome of motor symptoms was set as the dependent variable.</p><p><strong>Conclusions: </strong>We showed that midbrain size evaluated using the One-Line Method was a good predictor of the motor outcome after STN-DBS, but volume measured using FreeSurfer was not. The One-Line Method was considered to detect changes in size specifically in the midbrain tegmentum, which is associated with PD motor symptoms. Thus, we present a simple and useful method for predicting poor outcomes after STN-DBS treatment in patients with PD with disease progression.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"271"},"PeriodicalIF":2.4,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-18DOI: 10.1007/s10072-026-08869-w
Hamza Adel Salim, Luca Scarcia, Frédéric Clarençon, Orabi Hajjeh, Motaz Daraghma, Davide Simonato, Yan-Lin Li, Eimad Shotar, Kevin Premat, Pascal Jabbour, Stavropoula I Tjoumakaris, Reid M Gooch, Marios Psychogios, Nikos Ntoulias, Peter Sporns, Ajit S Puri, Jasmeet Singh, Anna Luisa Kuhn, Ameer E Hassan, Oktay Algin, Markus A Möhlenbruch, Sophia Hohenstatt, Riccardo Russo, Mauro Bergui, Oded Goren, Matthew J Kole, Nourou Dine Adeniran Bankole, Richard Bibi, Gregoire Boulouis, Takeshi Morimoto, Fumihiro Sakakibara, Raoul Pop, Ciprian Juravle, Joanna W K Ho, Ãngel Ferrario, Virginia Pujol Lereis, Jared Cooper, Chirag D Gandhi, Giancarlo Salsano, Lucio Castellan, Arturo Consoli, Alessandro Sgreccia, Eytan Raz, Charlotte Chung, Julien Burel, Chrysanthi Papagiannaki, Umair Rasheed, Khawaja Muhammad Baqir Hassan, Hong Tao, Zhe Ji, Riitta Rautio, Matias Sinisalo, Maria Ruggiero, Elvis Lafe, Valerio Da Ros, Luigi Bellini, Joseph Domenico Gabrieli, Francesco Causin, Michael R Levitt, Kate Carroll, Zachary Abecassis, Antonio Armando Caragliano, Sergio Lucio Vinci, Guillaume Bellanger, Christophe Cognard, Gaultier Marnat, Lisa Saleille, Nicola Limbucci, Francesco Capasso, Mariangela Piano, Claudia Rollo, Alexis Guedon, Francesco Arpaia, Andrea Romi, Fortunato Di Caterino, Alessandra Biondi, Erwah Kalsoum, Mykola Vyval, Adrien Guenego, Than Nguyen, Mohamad Abdalkader, Thibault Agripnidis, Aman B Patel, Vitor Mendes Pereira, Maurizio Fuschi, Alessandro Pedicelli, Vivek Yedavalli, Max Wintermark, Andrea M Alexandre, Adam A Dmytriw
{"title":"Comparative safety, efficacy, and predictors of complete occlusion of flow diverter devices in the treatment of unruptured distal anterior cerebral artery aneurysms.","authors":"Hamza Adel Salim, Luca Scarcia, Frédéric Clarençon, Orabi Hajjeh, Motaz Daraghma, Davide Simonato, Yan-Lin Li, Eimad Shotar, Kevin Premat, Pascal Jabbour, Stavropoula I Tjoumakaris, Reid M Gooch, Marios Psychogios, Nikos Ntoulias, Peter Sporns, Ajit S Puri, Jasmeet Singh, Anna Luisa Kuhn, Ameer E Hassan, Oktay Algin, Markus A Möhlenbruch, Sophia Hohenstatt, Riccardo Russo, Mauro Bergui, Oded Goren, Matthew J Kole, Nourou Dine Adeniran Bankole, Richard Bibi, Gregoire Boulouis, Takeshi Morimoto, Fumihiro Sakakibara, Raoul Pop, Ciprian Juravle, Joanna W K Ho, Ãngel Ferrario, Virginia Pujol Lereis, Jared Cooper, Chirag D Gandhi, Giancarlo Salsano, Lucio Castellan, Arturo Consoli, Alessandro Sgreccia, Eytan Raz, Charlotte Chung, Julien Burel, Chrysanthi Papagiannaki, Umair Rasheed, Khawaja Muhammad Baqir Hassan, Hong Tao, Zhe Ji, Riitta Rautio, Matias Sinisalo, Maria Ruggiero, Elvis Lafe, Valerio Da Ros, Luigi Bellini, Joseph Domenico Gabrieli, Francesco Causin, Michael R Levitt, Kate Carroll, Zachary Abecassis, Antonio Armando Caragliano, Sergio Lucio Vinci, Guillaume Bellanger, Christophe Cognard, Gaultier Marnat, Lisa Saleille, Nicola Limbucci, Francesco Capasso, Mariangela Piano, Claudia Rollo, Alexis Guedon, Francesco Arpaia, Andrea Romi, Fortunato Di Caterino, Alessandra Biondi, Erwah Kalsoum, Mykola Vyval, Adrien Guenego, Than Nguyen, Mohamad Abdalkader, Thibault Agripnidis, Aman B Patel, Vitor Mendes Pereira, Maurizio Fuschi, Alessandro Pedicelli, Vivek Yedavalli, Max Wintermark, Andrea M Alexandre, Adam A Dmytriw","doi":"10.1007/s10072-026-08869-w","DOIUrl":"10.1007/s10072-026-08869-w","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"270"},"PeriodicalIF":2.4,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12916520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-17DOI: 10.1007/s10072-025-08652-3
Maryam Zakerihamidi, Fatemeh Bagheri, Mohammad Heidarzadeh, Hassan Boskabadi
{"title":"Comparison of the prognosis of asphyxiated infants receiving hypothermia therapy with those receiving erythropoietin: a prospective cohort study.","authors":"Maryam Zakerihamidi, Fatemeh Bagheri, Mohammad Heidarzadeh, Hassan Boskabadi","doi":"10.1007/s10072-025-08652-3","DOIUrl":"10.1007/s10072-025-08652-3","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"266"},"PeriodicalIF":2.4,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146207379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-17DOI: 10.1007/s10072-026-08884-x
Medora C D'Souza Dias, Andre Fernandes, Balaaji Thirumaran
{"title":"Cavum septum pellucidum, prevalence of the anatomical anomaly in clinical neurology practice.","authors":"Medora C D'Souza Dias, Andre Fernandes, Balaaji Thirumaran","doi":"10.1007/s10072-026-08884-x","DOIUrl":"10.1007/s10072-026-08884-x","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"268"},"PeriodicalIF":2.4,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146207369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-16DOI: 10.1007/s10072-025-08789-1
Mariana Letícia de Bastos Maximiano, Ocilio Ribeiro Gonçalves, Filipe Virgilio Ribeiro, Mariana Lee Han, Altair Pereira de Melo Neto, João Vitor Andrade Fernandes, Marianna Leite, Anderson Matheus Pereira da Silva, Ahmet Günkan
Introduction: The optimal timing for anticoagulation after acute ischemic stroke (AIS) in patients with atrial fibrillation (AF) remains unclear. This meta-analysis compared the efficacy and safety of early versus late anticoagulation initiation.
Methods: A systematic search of PubMed, Embase, Cochrane CENTRAL, and ScienceDirect (up to June 2025) identified randomized controlled trials (RCT) comparing early and late anticoagulation in adults with AIS and AF. Outcomes included a composite of recurrent ischemic stroke, symptomatic intracerebral hemorrhage, or death, plus individual outcomes for mortality, recurrent stroke, hemorrhagic events, and functional independence. Data were pooled using random-effects models to calculate risk ratios (RR) with 95% confidence intervals (CI).
Results: Four RCT (6722 patients) were included. The primary outcome occurred in 3.9% with early and 4.8% with late anticoagulation (RR 0.81; 95% CI 0.63-1.04; p = 0.10; I²=3.8%). Among patients receiving reperfusion therapy, rates were 3.2% vs. 3.9% (RR 0.83; 95% CI 0.53-1.28; p = 0.40). Mortality was 6.9% vs. 7.2% (RR 0.96; 95% CI 0.80-1.14; p = 0.61), ischemic stroke 2.3% vs. 2.9% (RR 0.77; 95% CI 0.53-1.13; p = 0.19), hemorrhagic events 0.8% vs. 1.3% (RR 0.68; 95% CI 0.41-1.13; p = 0.14), and functional independence (mRS 0-2) 66.3% vs. 65.4% (RR 1.01; 95% CI 0.95-1.07; p = 0.75).
Conclusion: Early anticoagulation after AIS in AF patients showed comparable efficacy and safety to delayed initiation, supporting its use in appropriately selected patients with predominantly mild-to-moderate ischemic stroke.
心房颤动（AF）患者急性缺血性卒中（AIS）后抗凝治疗的最佳时机尚不清楚。本荟萃分析比较了早期抗凝和晚期抗凝的疗效和安全性。方法：系统检索PubMed、Embase、Cochrane CENTRAL和ScienceDirect（截至2025年6月），确定了比较AIS和AF成人早期和晚期抗凝治疗的随机对照试验（RCT）。结果包括复发性缺血性卒中、症状性脑出血或死亡的综合结果，以及死亡率、复发性卒中、出血性事件和功能独立性的个体结果。采用随机效应模型合并数据，以95%置信区间（CI）计算风险比（RR）。结果：纳入4项RCT（6722例）。早期抗凝发生率为3.9%，晚期抗凝发生率为4.8% （RR 0.81; 95% CI 0.63-1.04; p = 0.10; I²=3.8%）。在接受再灌注治疗的患者中，发生率为3.2%对3.9% （RR 0.83; 95% CI 0.53-1.28; p = 0.40）。死亡率为6.9%比7.2% (RR 0.96; 95% CI 0.80-1.14; p = 0.61)，缺血性卒中2.3%比2.9% (RR 0.77; 95% CI 0.53-1.13; p = 0.19)，出血性事件0.8%比1.3% (RR 0.68; 95% CI 0.41-1.13; p = 0.14)，功能独立性（mRS 0-2） 66.3%比65.4% （RR 1.01; 95% CI 0.95-1.07; p = 0.75）。结论：AF患者AIS后早期抗凝的疗效和安全性与延迟开始抗凝相当，支持在适当选择的以轻中度缺血性卒中为主的患者中使用。
{"title":"Early versus late anticoagulation treatment after acute ischemic stroke with atrial fibrillation: a meta-analysis of randomized controlled trials.","authors":"Mariana Letícia de Bastos Maximiano, Ocilio Ribeiro Gonçalves, Filipe Virgilio Ribeiro, Mariana Lee Han, Altair Pereira de Melo Neto, João Vitor Andrade Fernandes, Marianna Leite, Anderson Matheus Pereira da Silva, Ahmet Günkan","doi":"10.1007/s10072-025-08789-1","DOIUrl":"10.1007/s10072-025-08789-1","url":null,"abstract":"<p><strong>Introduction: </strong>The optimal timing for anticoagulation after acute ischemic stroke (AIS) in patients with atrial fibrillation (AF) remains unclear. This meta-analysis compared the efficacy and safety of early versus late anticoagulation initiation.</p><p><strong>Methods: </strong>A systematic search of PubMed, Embase, Cochrane CENTRAL, and ScienceDirect (up to June 2025) identified randomized controlled trials (RCT) comparing early and late anticoagulation in adults with AIS and AF. Outcomes included a composite of recurrent ischemic stroke, symptomatic intracerebral hemorrhage, or death, plus individual outcomes for mortality, recurrent stroke, hemorrhagic events, and functional independence. Data were pooled using random-effects models to calculate risk ratios (RR) with 95% confidence intervals (CI).</p><p><strong>Results: </strong>Four RCT (6722 patients) were included. The primary outcome occurred in 3.9% with early and 4.8% with late anticoagulation (RR 0.81; 95% CI 0.63-1.04; p = 0.10; I²=3.8%). Among patients receiving reperfusion therapy, rates were 3.2% vs. 3.9% (RR 0.83; 95% CI 0.53-1.28; p = 0.40). Mortality was 6.9% vs. 7.2% (RR 0.96; 95% CI 0.80-1.14; p = 0.61), ischemic stroke 2.3% vs. 2.9% (RR 0.77; 95% CI 0.53-1.13; p = 0.19), hemorrhagic events 0.8% vs. 1.3% (RR 0.68; 95% CI 0.41-1.13; p = 0.14), and functional independence (mRS 0-2) 66.3% vs. 65.4% (RR 1.01; 95% CI 0.95-1.07; p = 0.75).</p><p><strong>Conclusion: </strong>Early anticoagulation after AIS in AF patients showed comparable efficacy and safety to delayed initiation, supporting its use in appropriately selected patients with predominantly mild-to-moderate ischemic stroke.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"265"},"PeriodicalIF":2.4,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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