Pub Date : 2026-02-23DOI: 10.1007/s10072-026-08897-6
Polona Rus Prelog, Matija Zupan, Senta Frol
{"title":"Post-stroke psychosis and antipsychotics: an unresolved therapeutic paradox.","authors":"Polona Rus Prelog, Matija Zupan, Senta Frol","doi":"10.1007/s10072-026-08897-6","DOIUrl":"10.1007/s10072-026-08897-6","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-23DOI: 10.1007/s10072-026-08877-w
Berna Özbey Eker, Kübra Yeni
{"title":"Association between lower urinary tract symptoms on quality of life in women with multiple sclerosis: The mediating role of loneliness.","authors":"Berna Özbey Eker, Kübra Yeni","doi":"10.1007/s10072-026-08877-w","DOIUrl":"10.1007/s10072-026-08877-w","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Spinal cord injury (SCI) is characterized by its high incidence, high disability rate, and high treatment costs, making the development of effective therapeutic strategies a major focus. Secondary injury mechanisms in SCI involve complex processes such as inflammation, oxidative stress, and apoptosis, which are critical to patient prognosis.
Methods: This study investigates the role of SIRT1 in SCI repair, particularly its molecular mechanisms in regulating the P53/Nrf2 signaling pathway. By constructing a recombinant adenovirus overexpressing SIRT1 and conducting both in vitro and in vivo validation, we found that SIRT1 modulates the P53/Nrf2 pathway by downregulating P53 and upregulating Nrf2 expression, significantly inhibiting the expression of inflammatory factors TNF-α, IL-1β, and IL-6, while increasing the expression of the anti-inflammatory factor IL-10. Additionally, SIRT1 reduced apoptosis by regulating Bax and Bcl-2 expression, and enhanced cellular antioxidant capacity through activation of Nrf2. These regulatory effects significantly promoted motor function recovery in SCI rats.
Conclusion: This study provides mechanistic evidence for the neuroprotective role of SIRT1 in SCI and establishes a foundation for considering SIRT1 as a novel therapeutic target for SCI.
{"title":"Sirtuin1 modulates P53/Nrf2 pathway to promote spinal cord injury repair.","authors":"Xingxing Huang, Shengbo Shi, Zijing Zhang, Zetian Zhao, Junxiao Gao, Meng Zhang, Lu Qin, Xiaobing Yu","doi":"10.1007/s10072-025-08604-x","DOIUrl":"10.1007/s10072-025-08604-x","url":null,"abstract":"<p><strong>Objective: </strong>Spinal cord injury (SCI) is characterized by its high incidence, high disability rate, and high treatment costs, making the development of effective therapeutic strategies a major focus. Secondary injury mechanisms in SCI involve complex processes such as inflammation, oxidative stress, and apoptosis, which are critical to patient prognosis.</p><p><strong>Methods: </strong>This study investigates the role of SIRT1 in SCI repair, particularly its molecular mechanisms in regulating the P53/Nrf2 signaling pathway. By constructing a recombinant adenovirus overexpressing SIRT1 and conducting both in vitro and in vivo validation, we found that SIRT1 modulates the P53/Nrf2 pathway by downregulating P53 and upregulating Nrf2 expression, significantly inhibiting the expression of inflammatory factors TNF-α, IL-1β, and IL-6, while increasing the expression of the anti-inflammatory factor IL-10. Additionally, SIRT1 reduced apoptosis by regulating Bax and Bcl-2 expression, and enhanced cellular antioxidant capacity through activation of Nrf2. These regulatory effects significantly promoted motor function recovery in SCI rats.</p><p><strong>Conclusion: </strong>This study provides mechanistic evidence for the neuroprotective role of SIRT1 in SCI and establishes a foundation for considering SIRT1 as a novel therapeutic target for SCI.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Posterior reversible encephalopathy syndrome due to pituitrin for bronchiectasis with hemoptysis--a case report.","authors":"Xianru Peng, Zhongli Li, Haiting Xie, Haobo Shi, Zekui Fang","doi":"10.1007/s10072-026-08873-0","DOIUrl":"10.1007/s10072-026-08873-0","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-21DOI: 10.1007/s10072-026-08892-x
Emma Falato, Martina Di Carluccio, Francesco Bugamelli, Simona Paola Carbone, Maria Chiara Pantuliano, Fioravante Capone, Fabio Pilato, Vincenzo Di Lazzaro
{"title":"Predictors of post-lumbar puncture headache in an academic outpatient neurology setting: a retrospective exploratory study.","authors":"Emma Falato, Martina Di Carluccio, Francesco Bugamelli, Simona Paola Carbone, Maria Chiara Pantuliano, Fioravante Capone, Fabio Pilato, Vincenzo Di Lazzaro","doi":"10.1007/s10072-026-08892-x","DOIUrl":"10.1007/s10072-026-08892-x","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-21DOI: 10.1007/s10072-026-08910-y
Agnieszka Antos, Adam Przybyłkowski, Jan Bembenek, Agnieszka Pęczuła, Anna Członkowska, Tomasz Litwin
{"title":"Wilson's disease: does a neuropsychiatric phenotype without liver involvement truly exist?","authors":"Agnieszka Antos, Adam Przybyłkowski, Jan Bembenek, Agnieszka Pęczuła, Anna Członkowska, Tomasz Litwin","doi":"10.1007/s10072-026-08910-y","DOIUrl":"10.1007/s10072-026-08910-y","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-20DOI: 10.1007/s10072-026-08844-5
Yifeng Lin, Zhenyu Xiao, Peng Zhang
{"title":"A case report and literature review of multiple complications in the treatment of an aneurysm with the woven endobridge device.","authors":"Yifeng Lin, Zhenyu Xiao, Peng Zhang","doi":"10.1007/s10072-026-08844-5","DOIUrl":"10.1007/s10072-026-08844-5","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"277"},"PeriodicalIF":2.4,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-20DOI: 10.1007/s10072-026-08842-7
Sena Aksoy, Arsida Bajrami, Songül Şenadım, Serdar Geyik
{"title":"Correction to: Tirofiban-induced lingual edema and thrombocytopenia during management of ischemic stroke: a case report.","authors":"Sena Aksoy, Arsida Bajrami, Songül Şenadım, Serdar Geyik","doi":"10.1007/s10072-026-08842-7","DOIUrl":"10.1007/s10072-026-08842-7","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":"47 3","pages":"276"},"PeriodicalIF":2.4,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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