首页 > 最新文献

Neuro-oncology practice最新文献

英文 中文
European Association of Neuro-Oncology’s 30th anniversary: A successful and growing relationship with Neuro-Oncology Practice 欧洲神经肿瘤协会成立 30 周年:与神经肿瘤学实践建立了成功且不断发展的关系
IF 2.4 Q2 CLINICAL NEUROLOGY Pub Date : 2024-08-10 DOI: 10.1093/nop/npae061
M. Taphoorn, N. Galldiks, M. Preusser, M. Platten, Susan C Short
{"title":"European Association of Neuro-Oncology’s 30th anniversary: A successful and growing relationship with Neuro-Oncology Practice","authors":"M. Taphoorn, N. Galldiks, M. Preusser, M. Platten, Susan C Short","doi":"10.1093/nop/npae061","DOIUrl":"https://doi.org/10.1093/nop/npae061","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141919397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical outcomes for pleomorphic xanthoastrocytoma patients 多形性黄细胞瘤患者的临床疗效
IF 2.4 Q2 CLINICAL NEUROLOGY Pub Date : 2024-08-10 DOI: 10.1093/nop/npae074
Jared Sullivan, James P. Chandler, Maciej S. Lesniak, Matthew C. Tate, A. Sonabend, John A Kalapurakal, Craig Horbinski, R. Lukas, Priya Kumthekar, S. Sachdev
Report our institutional experience with pleomorphic xanthoastrocytoma (PXA) to contribute to limited data on optimal management. Patients with pathologically confirmed PXA treated at our institution between 1990 and 2019 were identified. Demographic information, tumor grade, treatment variables, and clinical outcomes were collected from patient charts. Kaplan-Meier estimates were used to summarize two primary outcome measurements: progression-free survival (PFS) and overall survival (OS). Outcomes were stratified by tumor grade and extent of resection. Cox regression and log-rank testing were performed. We identified 17 patients with pathologically confirmed PXA. Two patients were excluded due to incomplete treatment information or <6m of follow-up; 15 patients were analyzed (median follow-up 4.4y). Six patients had grade 2 PXA and 9 had grade 3 anaplastic PXA. The 2-year and 5-year PFS for the cohort was 57% and 33%, respectively; 2-year and 5-year OS was 93% and 75%, respectively. Patients with grade 2 tumors exhibited superior PFS compared to those with grade 3 tumors (2-year PFS: 100% vs. 28%, 5-year PFS: 60% vs. 14%), hazard ratio, 5.09 (95% CI: 1.06-24.50), p = 0.02. Undergoing a GTR was associated with numerical longer survival but this was not of statistical significance (hazard ratio: 0.38, p = 0.15). All but one (89%) of the grade 3 patients underwent RT. The poor survival of the cohort, especially with grade 3 tumors, suggests the need for more aggressive treatment, including maximal resection followed by intensive adjuvant therapy. Better prognostics of tumor recurrence are needed to guide the use of adjuvant therapy.
报告本院治疗多形性黄细胞瘤(PXA)的经验,为有限的最佳治疗数据做出贡献。 我们对 1990 年至 2019 年期间在本院接受病理确诊的 PXA 患者进行了鉴定。从患者病历中收集了人口统计学信息、肿瘤分级、治疗变量和临床结果。卡普兰-梅耶估计值用于总结两个主要结局指标:无进展生存期(PFS)和总生存期(OS)。结果按肿瘤分级和切除范围进行分层。进行了 Cox 回归和对数秩检验。 我们发现了 17 例经病理证实的 PXA 患者。有两名患者因治疗信息不全或随访时间少于6米而被排除在外;15名患者接受了分析(中位随访时间为4.4年)。6名患者为2级PXA,9名患者为3级无细胞PXA。组群的2年和5年PFS分别为57%和33%;2年和5年OS分别为93%和75%。2级肿瘤患者的PFS优于3级肿瘤患者(2年PFS:100% vs. 28%,5年PFS:60% vs. 14%),危险比为5.09(95% CI:1.06-24.50),P = 0.02。接受 GTR 与数字生存期延长有关,但无统计学意义(危险比:0.38,P = 0.15)。除一名患者(89%)外,所有 3 级患者都接受了 RT 治疗。 该组患者的生存率较低,尤其是3级肿瘤患者,这表明需要进行更积极的治疗,包括最大限度切除肿瘤,然后进行强化辅助治疗。需要更好的肿瘤复发预后来指导辅助治疗的使用。
{"title":"Clinical outcomes for pleomorphic xanthoastrocytoma patients","authors":"Jared Sullivan, James P. Chandler, Maciej S. Lesniak, Matthew C. Tate, A. Sonabend, John A Kalapurakal, Craig Horbinski, R. Lukas, Priya Kumthekar, S. Sachdev","doi":"10.1093/nop/npae074","DOIUrl":"https://doi.org/10.1093/nop/npae074","url":null,"abstract":"\u0000 \u0000 \u0000 Report our institutional experience with pleomorphic xanthoastrocytoma (PXA) to contribute to limited data on optimal management.\u0000 \u0000 \u0000 \u0000 Patients with pathologically confirmed PXA treated at our institution between 1990 and 2019 were identified. Demographic information, tumor grade, treatment variables, and clinical outcomes were collected from patient charts. Kaplan-Meier estimates were used to summarize two primary outcome measurements: progression-free survival (PFS) and overall survival (OS). Outcomes were stratified by tumor grade and extent of resection. Cox regression and log-rank testing were performed.\u0000 \u0000 \u0000 \u0000 We identified 17 patients with pathologically confirmed PXA. Two patients were excluded due to incomplete treatment information or <6m of follow-up; 15 patients were analyzed (median follow-up 4.4y). Six patients had grade 2 PXA and 9 had grade 3 anaplastic PXA. The 2-year and 5-year PFS for the cohort was 57% and 33%, respectively; 2-year and 5-year OS was 93% and 75%, respectively. Patients with grade 2 tumors exhibited superior PFS compared to those with grade 3 tumors (2-year PFS: 100% vs. 28%, 5-year PFS: 60% vs. 14%), hazard ratio, 5.09 (95% CI: 1.06-24.50), p = 0.02. Undergoing a GTR was associated with numerical longer survival but this was not of statistical significance (hazard ratio: 0.38, p = 0.15). All but one (89%) of the grade 3 patients underwent RT.\u0000 \u0000 \u0000 \u0000 The poor survival of the cohort, especially with grade 3 tumors, suggests the need for more aggressive treatment, including maximal resection followed by intensive adjuvant therapy. Better prognostics of tumor recurrence are needed to guide the use of adjuvant therapy.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141920483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
European Association of Neuro-Oncology’s 30th anniversary: A successful and growing relationship with Neuro-Oncology Practice 欧洲神经肿瘤协会成立 30 周年:与神经肿瘤学实践建立了成功且不断发展的关系
IF 2.4 Q2 CLINICAL NEUROLOGY Pub Date : 2024-08-10 DOI: 10.1093/nop/npae061
M. Taphoorn, N. Galldiks, M. Preusser, M. Platten, Susan C Short
{"title":"European Association of Neuro-Oncology’s 30th anniversary: A successful and growing relationship with Neuro-Oncology Practice","authors":"M. Taphoorn, N. Galldiks, M. Preusser, M. Platten, Susan C Short","doi":"10.1093/nop/npae061","DOIUrl":"https://doi.org/10.1093/nop/npae061","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141919851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Financial Toxicity of Oral Chemotherapy in Patients with Primary Brain Tumors 原发性脑肿瘤患者口服化疗的经济毒性
IF 2.4 Q2 CLINICAL NEUROLOGY Pub Date : 2024-08-09 DOI: 10.1093/nop/npae073
Mallika P. Patel, M. Affronti, Evan D Buckley, James E. Herndon II, Emma M Mackowsky, Margaret O Johnson, Katherine B Peters
Cancer treatment costs continue to rise with the development of new agents. Financial toxicity is defined as the quantifiable costs associated with cancer and cancer treatment in addition to the patient’s associated distress. This study's rationale is to better understand the financial burden of oral chemotherapies from the perspective of patients with primary brain tumors. After one cycle of oral chemotherapy, we requested patients to complete the Financial Toxicity-Functional Assessment of Chronic Illness Therapy (COST-FACIT) survey and additional questions relevant to insurance and cost. We summarized responses with descriptive statistics within strata defined by on-label or off-label oral therapy. Sixty surveys were completed, with most patients (n = 53, 88%) receiving on-label therapy; only 7 patients (12%) received off-label oral agents. The mean overall financial toxicity score was 23.1 (SD=11.3). When asked if their provider discussed treatment cost before initiation, 21 patients (35%) stated that they did, and 39 patients (65%) said they did not discuss cost or did not recall. However, in the off-label cohort, all seven patients stated that their provider discussed the cost before prescribing. Most patients (70%) had co-pays. Nine (17%) in the on-label group and 3 (43%) in the off-label group had chemotherapy-associated costs that negatively affected their quality of life. A higher percentage of financial distress occurred in the off-label group. Discussing medication costs with patients is an essential part of chemotherapy initiation and may mitigate undue psychosocial and financial distress.
随着新药的开发,癌症治疗费用不断增加。经济毒性的定义是与癌症和癌症治疗相关的可量化成本,以及患者的相关痛苦。本研究的目的是从原发性脑肿瘤患者的角度出发,更好地了解口服化疗的经济负担。 在一个周期的口服化疗后,我们要求患者完成慢性疾病治疗的经济毒性-功能评估(COST-FACIT)调查以及与保险和费用相关的其他问题。我们在标示内或标示外口服疗法所定义的分层内通过描述性统计对答复进行了总结。 共完成了 60 份调查问卷,其中大多数患者(n = 53,88%)接受了标签内治疗;只有 7 名患者(12%)接受了标签外口服药物治疗。财务毒性总平均得分为 23.1(SD=11.3)。当被问及他们的医疗服务提供者是否在开始治疗前讨论过治疗费用时,21 名患者(35%)表示讨论过,39 名患者(65%)表示没有讨论过费用或不记得了。然而,在标签外组群中,所有 7 名患者都表示他们的医疗服务提供者在开处方前讨论过费用问题。大多数患者(70%)需要共同支付费用。标签内组有9名患者(17%)和标签外组有3名患者(43%)因化疗相关费用而对生活质量产生了负面影响。标签外组出现经济困难的比例较高。 与患者讨论用药费用是化疗开始阶段的重要组成部分,可减轻不必要的社会心理和经济困扰。
{"title":"Financial Toxicity of Oral Chemotherapy in Patients with Primary Brain Tumors","authors":"Mallika P. Patel, M. Affronti, Evan D Buckley, James E. Herndon II, Emma M Mackowsky, Margaret O Johnson, Katherine B Peters","doi":"10.1093/nop/npae073","DOIUrl":"https://doi.org/10.1093/nop/npae073","url":null,"abstract":"\u0000 \u0000 \u0000 Cancer treatment costs continue to rise with the development of new agents. Financial toxicity is defined as the quantifiable costs associated with cancer and cancer treatment in addition to the patient’s associated distress. This study's rationale is to better understand the financial burden of oral chemotherapies from the perspective of patients with primary brain tumors.\u0000 \u0000 \u0000 \u0000 After one cycle of oral chemotherapy, we requested patients to complete the Financial Toxicity-Functional Assessment of Chronic Illness Therapy (COST-FACIT) survey and additional questions relevant to insurance and cost. We summarized responses with descriptive statistics within strata defined by on-label or off-label oral therapy.\u0000 \u0000 \u0000 \u0000 Sixty surveys were completed, with most patients (n = 53, 88%) receiving on-label therapy; only 7 patients (12%) received off-label oral agents. The mean overall financial toxicity score was 23.1 (SD=11.3). When asked if their provider discussed treatment cost before initiation, 21 patients (35%) stated that they did, and 39 patients (65%) said they did not discuss cost or did not recall. However, in the off-label cohort, all seven patients stated that their provider discussed the cost before prescribing. Most patients (70%) had co-pays. Nine (17%) in the on-label group and 3 (43%) in the off-label group had chemotherapy-associated costs that negatively affected their quality of life. A higher percentage of financial distress occurred in the off-label group.\u0000 \u0000 \u0000 \u0000 Discussing medication costs with patients is an essential part of chemotherapy initiation and may mitigate undue psychosocial and financial distress.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141922393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rehabilitation utilization in malignant primary brain tumors compared to stroke and traumatic brain injury: Analysis using a large claim database 恶性原发性脑肿瘤与中风和脑外伤的康复利用率比较:利用大型索赔数据库进行分析
IF 2.4 Q2 CLINICAL NEUROLOGY Pub Date : 2024-07-16 DOI: 10.1093/nop/npae064
Samantha Giovanazzi, Beatrice Ugiliweneza, Elsa Alvarez, Maxwell Boakye, Darryl Kaelin, Megan B Nelson
There is concern regarding the underutilization of rehabilitation services for the malignant primary brain tumor (MPBT) population following hospitalization. Our aim is to assess physical therapy (PT), occupational therapy (OT), and speech-language pathology (SLP) use after a MPBT diagnosis, evaluate the trend from 2001-2018, and compare to traumatic brain injury (TBI) and stroke. Adult cases of MPBT, TBI, and stroke were extracted from MarketScan database. Inpatient and outpatient data were screened for inpatient rehabilitation use at the time of diagnosis and post-discharge outpatient PT, OT, and SLP over 12 months. Generalized linear regressions were used for analysis. Cohort was composed of 3,381 MPBT, 205,366 stroke, and 24,825 TBI patients. After diagnosis, 1% of MPBTs were discharged to skilled nursing facilities (SNF) and 3% to inpatient rehabilitation facilities (IRF). Rehabilitation use at 12 months was 19% PT, 8% OT, and 6% SLP. These percentages were lower than stroke and TBI; stroke: 8% SNF, 8% IRF, 22% PT, 10% OT, and 8% SLP; TBI: 7% SNF, 7% IRF, 22% PT, 8% OT, and 6% SLP. Outpatient therapies increased from 2001 to 2018, with PT use consistently higher than OT and SLP. MPBT had the greatest increases in OT (7.95 times) and PT (3.89 times) compared to stroke and TBI, while stroke had the greatest increase in SLP (.98 times). MPBT patients had the highest increase of OT and PT utilization when compared to stroke and TBI. However, there remains a utilization gap which demonstrates the need for improvement.
恶性原发性脑肿瘤(MPBT)患者住院后康复服务利用率不足的问题备受关注。我们的目的是评估确诊 MPBT 后物理治疗(PT)、职业治疗(OT)和言语病理治疗(SLP)的使用情况,评估 2001-2018 年的趋势,并与创伤性脑损伤(TBI)和中风进行比较。 从 MarketScan 数据库中提取了 MPBT、创伤性脑损伤和中风的成人病例。对住院病人和门诊病人数据进行筛查,以了解诊断时住院康复治疗的使用情况以及出院后 12 个月内门诊治疗 PT、OT 和 SLP 的使用情况。分析中使用了广义线性回归。 队列由 3,381 名 MPBT 患者、205,366 名中风患者和 24,825 名创伤性脑损伤患者组成。确诊后,1% 的 MPBT 患者出院后入住专业护理机构 (SNF),3% 入住住院康复机构 (IRF)。在 12 个月内使用康复治疗的患者中,19% 使用 PT,8% 使用 OT,6% 使用 SLP。这些百分比低于中风和创伤性脑损伤;中风:8% SNF、8% IRF、22% PT、10% OT 和 8% SLP;创伤性脑损伤:7% SNF、7% IRF、22% PT、8% OT 和 6% SLP。从 2001 年到 2018 年,门诊治疗有所增加,其中 PT 的使用率一直高于 OT 和 SLP。与中风和创伤性脑损伤相比,MPBT 在 OT(7.95 倍)和 PT(3.89 倍)方面的增幅最大,而中风在 SLP 方面的增幅最大(0.98 倍)。 与中风和创伤性脑损伤患者相比,MPBT 患者对 OT 和 PT 的使用增加最多。然而,利用率仍然存在差距,这表明需要加以改进。
{"title":"Rehabilitation utilization in malignant primary brain tumors compared to stroke and traumatic brain injury: Analysis using a large claim database","authors":"Samantha Giovanazzi, Beatrice Ugiliweneza, Elsa Alvarez, Maxwell Boakye, Darryl Kaelin, Megan B Nelson","doi":"10.1093/nop/npae064","DOIUrl":"https://doi.org/10.1093/nop/npae064","url":null,"abstract":"\u0000 \u0000 \u0000 There is concern regarding the underutilization of rehabilitation services for the malignant primary brain tumor (MPBT) population following hospitalization. Our aim is to assess physical therapy (PT), occupational therapy (OT), and speech-language pathology (SLP) use after a MPBT diagnosis, evaluate the trend from 2001-2018, and compare to traumatic brain injury (TBI) and stroke.\u0000 \u0000 \u0000 \u0000 Adult cases of MPBT, TBI, and stroke were extracted from MarketScan database. Inpatient and outpatient data were screened for inpatient rehabilitation use at the time of diagnosis and post-discharge outpatient PT, OT, and SLP over 12 months. Generalized linear regressions were used for analysis.\u0000 \u0000 \u0000 \u0000 Cohort was composed of 3,381 MPBT, 205,366 stroke, and 24,825 TBI patients. After diagnosis, 1% of MPBTs were discharged to skilled nursing facilities (SNF) and 3% to inpatient rehabilitation facilities (IRF). Rehabilitation use at 12 months was 19% PT, 8% OT, and 6% SLP. These percentages were lower than stroke and TBI; stroke: 8% SNF, 8% IRF, 22% PT, 10% OT, and 8% SLP; TBI: 7% SNF, 7% IRF, 22% PT, 8% OT, and 6% SLP. Outpatient therapies increased from 2001 to 2018, with PT use consistently higher than OT and SLP. MPBT had the greatest increases in OT (7.95 times) and PT (3.89 times) compared to stroke and TBI, while stroke had the greatest increase in SLP (.98 times).\u0000 \u0000 \u0000 \u0000 MPBT patients had the highest increase of OT and PT utilization when compared to stroke and TBI. However, there remains a utilization gap which demonstrates the need for improvement.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141642960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Subjectively and Objectively Measured Sleep-Wake Patterns Among Patients with Primary Brain Tumors 原发性脑肿瘤患者主观和客观睡眠-觉醒模式的比较
IF 2.4 Q2 CLINICAL NEUROLOGY Pub Date : 2024-07-16 DOI: 10.1093/nop/npae062
Youngdeok Kim, J. Kenyon, Jisu Kim, Kelcie D Willis, Autumn Lanoye, A. Loughan
The sleep diary and wrist-worn actigraphy are widely used to assess sleep disturbances in patients with primary brain tumors (PwPBT) in both clinical and research settings. However, their comparability has not been systematically examined. This study aimed to compare the sleep-wake patterns measured using the subjectively measured Consensus Sleep Diary (CSD) and the objectively measured ActiGraph (AG) actigraphy among PwPBT. Sleep-wake patterns were assessed through CSD and AG over 14 consecutive nights across two occasions among 30 PwPBT. AG data were processed with AG proprietary and open-source GGIR algorithms, both with and without the assistance of CSD. Thirteen sleep parameters covering sleep-wake times, sleep disruptions, sleep durations, and sleep efficiency were compared using equivalency testing, mean absolute percent error (MAPE), and intra-class correlation (ICC). The estimated sleep parameters were correlated with perceived sleep quality and compared across the different sleep measures. Significant between-measure equivalency was claimed for sleep-wake time parameters (Ps≤.05), with acceptable MAPEs (<10%). Sleep disruption parameters such as wake-after-sleep-onset were not statistically equivalent, with a large MAPE (≥10%) between the measures. Sleep efficiency was equivalent, though varied depending on how sleep efficiency was calculated. For most sleep parameters, ICCs were low and unacceptable (<.50) suggesting incomparability between the measures. Lastly, CSD-derived sleep parameters exhibited a stronger correlation with perceived sleep quality compared to actigraphy measures. The findings suggest the incomparability of sleep parameters estimated from different measures. Both subjective and objective measures are recommended to better describe sleep health among PwPBT.
在临床和研究环境中,睡眠日记和腕戴式动图被广泛用于评估原发性脑肿瘤(PwPBT)患者的睡眠障碍。然而,这两种方法的可比性尚未得到系统研究。本研究旨在比较使用主观测量的 "共识睡眠日记"(CSD)和客观测量的 "ActiGraph(AG)动图 "对原发性脑肿瘤患者睡眠-觉醒模式的测量结果。 通过 CSD 和 AG 对 30 名 PwPBT 两次连续 14 个晚上的睡眠-觉醒模式进行了评估。AG 数据采用 AG 专有和开源的 GGIR 算法进行处理,既有 CSD 协助,也有 CSD 不协助的情况。使用等效测试、平均绝对百分比误差 (MAPE) 和类内相关性 (ICC) 对包括睡眠-觉醒时间、睡眠中断、睡眠持续时间和睡眠效率在内的 13 个睡眠参数进行了比较。估算的睡眠参数与感知的睡眠质量相关,并在不同的睡眠测量中进行比较。 睡眠-觉醒时间参数具有显著的测量间等效性(Ps≤.05),平均绝对误差(MAPE)可接受(<10%)。睡眠中断参数(如睡眠开始后的唤醒)在统计学上不等同,测量之间的 MAPE 较大(≥10%)。睡眠效率是等效的,但因睡眠效率的计算方法而异。对于大多数睡眠参数来说,ICCs 都很低且不可接受(<.50),这表明测量结果之间不具有可比性。最后,与动觉测量法相比,CSD 得出的睡眠参数与感知睡眠质量的相关性更强。 研究结果表明,不同测量方法估算出的睡眠参数不具可比性。建议采用主观和客观测量方法来更好地描述残疾人的睡眠健康状况。
{"title":"Comparison of Subjectively and Objectively Measured Sleep-Wake Patterns Among Patients with Primary Brain Tumors","authors":"Youngdeok Kim, J. Kenyon, Jisu Kim, Kelcie D Willis, Autumn Lanoye, A. Loughan","doi":"10.1093/nop/npae062","DOIUrl":"https://doi.org/10.1093/nop/npae062","url":null,"abstract":"\u0000 \u0000 \u0000 The sleep diary and wrist-worn actigraphy are widely used to assess sleep disturbances in patients with primary brain tumors (PwPBT) in both clinical and research settings. However, their comparability has not been systematically examined. This study aimed to compare the sleep-wake patterns measured using the subjectively measured Consensus Sleep Diary (CSD) and the objectively measured ActiGraph (AG) actigraphy among PwPBT.\u0000 \u0000 \u0000 \u0000 Sleep-wake patterns were assessed through CSD and AG over 14 consecutive nights across two occasions among 30 PwPBT. AG data were processed with AG proprietary and open-source GGIR algorithms, both with and without the assistance of CSD. Thirteen sleep parameters covering sleep-wake times, sleep disruptions, sleep durations, and sleep efficiency were compared using equivalency testing, mean absolute percent error (MAPE), and intra-class correlation (ICC). The estimated sleep parameters were correlated with perceived sleep quality and compared across the different sleep measures.\u0000 \u0000 \u0000 \u0000 Significant between-measure equivalency was claimed for sleep-wake time parameters (Ps≤.05), with acceptable MAPEs (<10%). Sleep disruption parameters such as wake-after-sleep-onset were not statistically equivalent, with a large MAPE (≥10%) between the measures. Sleep efficiency was equivalent, though varied depending on how sleep efficiency was calculated. For most sleep parameters, ICCs were low and unacceptable (<.50) suggesting incomparability between the measures. Lastly, CSD-derived sleep parameters exhibited a stronger correlation with perceived sleep quality compared to actigraphy measures.\u0000 \u0000 \u0000 \u0000 The findings suggest the incomparability of sleep parameters estimated from different measures. Both subjective and objective measures are recommended to better describe sleep health among PwPBT.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141644132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of Operative Ischemic Cerebrovascular Complications in Skull Base Tumor Resections: Experience in Low Resource Setting 颅底肿瘤切除术中缺血性脑血管并发症的预测因素:低资源环境中的经验
IF 2.4 Q2 CLINICAL NEUROLOGY Pub Date : 2024-07-15 DOI: 10.1093/nop/npae063
Mestet Yibeltal Shiferaw, A. S. Baleh, Abel Gizaw, T. Teklemariam, A. Aklilu, A. Awedew, Denekew Tenaw Anley, Bereket Hailu Mekuria, Ermias Fikru Yesuf, Mengistu Ayele Yigzaw, Henock Teshome Molla, Alemu Adise Mildie, Mekides Musie Awano, Abraham Teym
Ischemic cerebrovascular complications following skull base tumor resections remain a significant factor impacting both short-term and long-term patient outcomes. This study aims to improve risk stratification, surgical decision-making and postoperative care protocols. A retrospective cohort study on predictors of ischemic cerebrovascular complications among patients who underwent skull base tumor resection was conducted at two high-volume neurosurgical centers in Ethiopia from 2018 - 2023. Binary logistic analysis was performed to see the association of each predictor variable. The study included 266 patients, with 65.5% being female. The median age and tumor size were 37 (±IQR=17) years and 4.9cm (± IQR 1.5) respectively. Ischemic cerebrovascular complications occurred in 19.9% of patients. Middle cranial fossa tumors and tumors spanning both anterior & middle cranial fossa (AOR = 6.75, 95% CI 1.66-27.54, p < 0.008), grade 3-5 vascular encasement (AOR = 5.04, 95% CI 1.79-14.12, p < 0.002), near-total resection and gross total resection (AOR = 2.89, 95% CI 1.01-8.24, p <0.048), and difficult hemostasis (AOR = 9.37, 95% CI 3.19-27.52, p < 0.000) were significantly associated with iatrogenic vascular injury. Sub-arachnoid hemorrhage had a statistically significant association with vasospasm (AOR = 12.27, 95% CI: 1.99-75.37, p = 0.007). Surgery-related ischemic cerebrovascular complications are common. Thorough perioperative risk stratification and proactive treatment planning are crucial to mitigate vascular insults associated with it. In low-resource settings, neurosurgical services are provided without advanced instruments, leading to more complications. Therefore, it's important to focus on improving neurosurgical setup to enhance patient outcomes.
颅底肿瘤切除术后缺血性脑血管并发症仍是影响患者短期和长期预后的重要因素。本研究旨在改进风险分层、手术决策和术后护理方案。 2018年至2023年,在埃塞俄比亚的两家大容量神经外科中心开展了一项关于颅底肿瘤切除术患者缺血性脑血管并发症预测因素的回顾性队列研究。研究人员进行了二元逻辑分析,以了解各预测变量之间的关联。 研究纳入了266名患者,其中65.5%为女性。中位年龄和肿瘤大小分别为37(±IQR=17)岁和4.9厘米(±IQR 1.5)。19.9%的患者出现缺血性脑血管并发症。中颅窝肿瘤和同时跨越前颅窝和中颅窝的肿瘤(AOR = 6.75,95% CI 1.66-27.54,P < 0.008)、3-5级血管包裹(AOR = 5.04,95% CI 1.79-14.12,P < 0.002)、近乎全切除和粗暴全切除(AOR = 2.89,95% CI 1.01-8.24,P <0.048)以及止血困难(AOR = 9.37,95% CI 3.19-27.52,P <0.000)与先天性血管损伤显著相关。蛛网膜下腔出血与血管痉挛有显著的统计学关联(AOR = 12.27,95% CI:1.99-75.37,p = 0.007)。 与手术相关的缺血性脑血管并发症很常见。彻底的围手术期风险分层和积极的治疗计划对于减轻与之相关的血管损伤至关重要。在资源匮乏的环境中,神经外科服务是在没有先进器械的情况下提供的,这导致了更多的并发症。因此,必须集中精力改善神经外科的设置,以提高患者的治疗效果。
{"title":"Predictors of Operative Ischemic Cerebrovascular Complications in Skull Base Tumor Resections: Experience in Low Resource Setting","authors":"Mestet Yibeltal Shiferaw, A. S. Baleh, Abel Gizaw, T. Teklemariam, A. Aklilu, A. Awedew, Denekew Tenaw Anley, Bereket Hailu Mekuria, Ermias Fikru Yesuf, Mengistu Ayele Yigzaw, Henock Teshome Molla, Alemu Adise Mildie, Mekides Musie Awano, Abraham Teym","doi":"10.1093/nop/npae063","DOIUrl":"https://doi.org/10.1093/nop/npae063","url":null,"abstract":"\u0000 \u0000 \u0000 Ischemic cerebrovascular complications following skull base tumor resections remain a significant factor impacting both short-term and long-term patient outcomes. This study aims to improve risk stratification, surgical decision-making and postoperative care protocols.\u0000 \u0000 \u0000 \u0000 A retrospective cohort study on predictors of ischemic cerebrovascular complications among patients who underwent skull base tumor resection was conducted at two high-volume neurosurgical centers in Ethiopia from 2018 - 2023. Binary logistic analysis was performed to see the association of each predictor variable.\u0000 \u0000 \u0000 \u0000 The study included 266 patients, with 65.5% being female. The median age and tumor size were 37 (±IQR=17) years and 4.9cm (± IQR 1.5) respectively. Ischemic cerebrovascular complications occurred in 19.9% of patients. Middle cranial fossa tumors and tumors spanning both anterior & middle cranial fossa (AOR = 6.75, 95% CI 1.66-27.54, p < 0.008), grade 3-5 vascular encasement (AOR = 5.04, 95% CI 1.79-14.12, p < 0.002), near-total resection and gross total resection (AOR = 2.89, 95% CI 1.01-8.24, p <0.048), and difficult hemostasis (AOR = 9.37, 95% CI 3.19-27.52, p < 0.000) were significantly associated with iatrogenic vascular injury. Sub-arachnoid hemorrhage had a statistically significant association with vasospasm (AOR = 12.27, 95% CI: 1.99-75.37, p = 0.007).\u0000 \u0000 \u0000 \u0000 Surgery-related ischemic cerebrovascular complications are common. Thorough perioperative risk stratification and proactive treatment planning are crucial to mitigate vascular insults associated with it. In low-resource settings, neurosurgical services are provided without advanced instruments, leading to more complications. Therefore, it's important to focus on improving neurosurgical setup to enhance patient outcomes.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141648508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chairing Scientific Sessions at International Neuro-Oncology Meetings - an EANO guide for early career professionals 在国际神经肿瘤学会议上主持科学会议--EANO 早期职业专业人员指南
IF 2.4 Q2 CLINICAL NEUROLOGY Pub Date : 2024-07-02 DOI: 10.1093/nop/npae060
J. Werner, G. Petrescu, F. Boele, M. Preusser, M. Platten, A. Chalmers, Susan C Short, K. Piil
{"title":"Chairing Scientific Sessions at International Neuro-Oncology Meetings - an EANO guide for early career professionals","authors":"J. Werner, G. Petrescu, F. Boele, M. Preusser, M. Platten, A. Chalmers, Susan C Short, K. Piil","doi":"10.1093/nop/npae060","DOIUrl":"https://doi.org/10.1093/nop/npae060","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141684663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Palliative care in neuro-oncology: The elephant in the room 神经肿瘤学中的姑息治疗:房间里的大象
IF 2.7 Q2 Medicine Pub Date : 2024-06-14 DOI: 10.1093/nop/npae053
Heather Leeper
{"title":"Palliative care in neuro-oncology: The elephant in the room","authors":"Heather Leeper","doi":"10.1093/nop/npae053","DOIUrl":"https://doi.org/10.1093/nop/npae053","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141343923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intrathecal Methotrexate, Central Nervous System Toxicity, and Response to NMDA Antagonism - An Adult Case Series 鞘内甲氨蝶呤、中枢神经系统毒性和对 NMDA 拮抗剂的反应 - 一个成人病例系列
IF 2.7 Q2 Medicine Pub Date : 2024-06-12 DOI: 10.1093/nop/npae051
Ryan Donaghy, Lauren Singer, Karan Dixit
Methotrexate (MTX) is administered for treatment of central nervous system (CNS) hematologic cancers, prophylaxis of CNS dissemination of certain hematological cancers, and in solid tumor leptomeningeal disease. MTX treatment can be limited by CNS toxicity. Dextromethorphan is used to treat MTX neurotoxicity, with most data derived from pediatric case series. In this report, we profile four adult patients who developed intrathecal (IT) MTX neurotoxicity to better characterize their response to dextromethorphan treatment. A case series of four patients who developed neurologic symptoms attributed to IT MTX neurotoxicity subsequently treated with dextromethorphan was devised. Demographic data, clinical characteristics, electroencephalography results, magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) characteristics, and dextromethorphan treatment outcomes were described. Of the four patients developing MTX neurotoxicity, neurologic symptoms developed over a timeframe of two to fourteen days from the precedent MTX exposure. Radiologic phenotypes included subcortical white matter diffusion-restricting lesions, bi-hemispheric subcortical white matter T2-FLAIR hyperintensities, as well other findings described in the report. Time elapsed from initiation of dextromethorphan to neurologic symptom resolution ranged from 1 to 2 days. The profiles of four adult patients developing suspected IT MTX neurotoxicity syndromes with subsequent response to Dextromethorphan add further data to guide management of such patients.
甲氨蝶呤(MTX)可用于治疗中枢神经系统(CNS)血液癌症、预防某些血液癌症在中枢神经系统的扩散以及实体瘤脑膜疾病。MTX 的治疗可能会受到中枢神经系统毒性的限制。右美沙芬用于治疗 MTX 神经毒性,大多数数据来自儿科病例系列。在本报告中,我们介绍了四名出现鞘内 (IT) MTX 神经毒性的成年患者,以更好地描述他们对右美沙芬治疗的反应。 我们设计了一个病例系列,收录了四名因 IT MTX 神经毒性而出现神经系统症状、随后接受右美沙芬治疗的患者。研究描述了患者的人口统计学数据、临床特征、脑电图结果、磁共振成像(MRI)、脑脊液(CSF)特征以及右美沙芬的治疗效果。 在出现MTX神经毒性的四名患者中,神经系统症状的出现时间为首次接触MTX后的2至14天。放射学表型包括皮层下白质弥散限制性病变、双半球皮层下白质T2-FLAIR高密度以及报告中描述的其他结果。从开始使用右美沙芬到神经症状缓解的时间为 1 到 2 天不等。 四名疑似 IT MTX 神经毒性综合征的成年患者对右美沙芬的反应为指导此类患者的治疗提供了更多数据。
{"title":"Intrathecal Methotrexate, Central Nervous System Toxicity, and Response to NMDA Antagonism - An Adult Case Series","authors":"Ryan Donaghy, Lauren Singer, Karan Dixit","doi":"10.1093/nop/npae051","DOIUrl":"https://doi.org/10.1093/nop/npae051","url":null,"abstract":"\u0000 \u0000 \u0000 Methotrexate (MTX) is administered for treatment of central nervous system (CNS) hematologic cancers, prophylaxis of CNS dissemination of certain hematological cancers, and in solid tumor leptomeningeal disease. MTX treatment can be limited by CNS toxicity. Dextromethorphan is used to treat MTX neurotoxicity, with most data derived from pediatric case series. In this report, we profile four adult patients who developed intrathecal (IT) MTX neurotoxicity to better characterize their response to dextromethorphan treatment.\u0000 \u0000 \u0000 \u0000 A case series of four patients who developed neurologic symptoms attributed to IT MTX neurotoxicity subsequently treated with dextromethorphan was devised. Demographic data, clinical characteristics, electroencephalography results, magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) characteristics, and dextromethorphan treatment outcomes were described.\u0000 \u0000 \u0000 \u0000 Of the four patients developing MTX neurotoxicity, neurologic symptoms developed over a timeframe of two to fourteen days from the precedent MTX exposure. Radiologic phenotypes included subcortical white matter diffusion-restricting lesions, bi-hemispheric subcortical white matter T2-FLAIR hyperintensities, as well other findings described in the report. Time elapsed from initiation of dextromethorphan to neurologic symptom resolution ranged from 1 to 2 days.\u0000 \u0000 \u0000 \u0000 The profiles of four adult patients developing suspected IT MTX neurotoxicity syndromes with subsequent response to Dextromethorphan add further data to guide management of such patients.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141351100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Neuro-oncology practice
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1