首页 > 最新文献

Neuro-oncology practice最新文献

英文 中文
Focal Leptomeningeal Vascular Anomalies on Brain MRI: A Mimic of Leptomeningeal Metastatic Disease 脑磁共振成像上的灶性脑膜血管异常:脑转移性疾病的一种表现形式
IF 2.7 Q2 Medicine Pub Date : 2024-06-07 DOI: 10.1093/nop/npae050
Alexandre Boutet, Mikail Malik, A. Yang, J. Germann, Samuel S Haile, Hyo Jin Son, Artur Vetkas, V. Pai, Warren P Mason, Gelareh Zadeh, Daniel M Mandell
The diagnosis of leptomeningeal metastatic disease has major prognostic and therapeutic implications. We report 13 patients with a radiologically distinct kind of focal, enhancing leptomeningeal lesion on brain MRI that mimics leptomeningeal metastatic disease. These patients were assessed at University Health Network (Toronto, Canada) between January 2001 and December 2023. Median age was 68 years (range, 55–78 years) and 10 patients were women. All patients had brain MRI including contrast-enhanced T2-weighted fluid attenuation inversion recovery (FLAIR) and T1-weighted spin echo sequences. MRI in all 13 patients showed a focal enhancing lesion located along the leptomeningeal surface of the brain. The MRI exams were reported as possible or likely leptomeningeal metastatic disease for the majority (9/13) of patients. Each lesion was curvilinear rather than sheet-like, and some lesions consisted of multiple connected/branching curvilinear structures with the appearance of abnormal vessels. Some lesions had a visible connection with a nearby cortical vein. The lesions were distinct from normal blood vessels. Follow-up contrast-enhanced brain MRI for 8/13 (62%) patients at a median of 3.9 years (IQR 2.4–6.6 years) showed all lesions were unchanged over time. Another 2/13 (15%) patients had clinical and CT brain follow-up after one year with no evidence of metastatic disease. We describe a distinct kind of focal, enhancing leptomeningeal lesion on brain MRI that mimics metastatic disease. These lesions are likely a type of low-flow vascular anomaly. Their curvilinear/branching shape and intense enhancement particularly on T2-weighted FLAIR images distinguishes these lesions from tumor.
脑膜转移性疾病的诊断对预后和治疗有重大影响。我们报告了13名患者,他们在脑磁共振成像中发现了一种放射学上独特的局灶性、增强性脑膜病变,与脑膜转移性疾病相似。 2001年1月至2023年12月期间,这些患者在加拿大多伦多大学健康网络接受了评估。 中位年龄为 68 岁(55-78 岁),10 名患者为女性。所有患者均接受了脑部磁共振成像检查,包括对比增强 T2 加权流体衰减反转恢复(FLAIR)和 T1 加权自旋回波序列。所有13名患者的核磁共振成像均显示,位于大脑中的脑膜表面有局灶性增强病变。大多数患者(9/13)的核磁共振检查报告为可能或疑似脑转移灶。每个病灶都呈曲线状,而不是片状,有些病灶由多个相连/分支的曲线结构组成,并伴有异常血管的外观。有些病变与附近的皮质静脉有明显的连接。病变与正常血管截然不同。8/13(62%)名患者在中位 3.9 年(IQR 2.4-6.6 年)的随访对比增强脑部 MRI 显示,所有病变均无变化。另有 2/13 名患者(15%)在一年后进行了临床和脑部 CT 随访,没有发现转移性疾病。 我们描述了一种在脑磁共振成像上模拟转移性疾病的独特的局灶性、增强性脑膜病变。这些病变很可能是一种低流量血管异常。这些病灶呈曲线/分支状,在T2加权FLAIR图像上呈强强化,这使它们与肿瘤区别开来。
{"title":"Focal Leptomeningeal Vascular Anomalies on Brain MRI: A Mimic of Leptomeningeal Metastatic Disease","authors":"Alexandre Boutet, Mikail Malik, A. Yang, J. Germann, Samuel S Haile, Hyo Jin Son, Artur Vetkas, V. Pai, Warren P Mason, Gelareh Zadeh, Daniel M Mandell","doi":"10.1093/nop/npae050","DOIUrl":"https://doi.org/10.1093/nop/npae050","url":null,"abstract":"\u0000 \u0000 \u0000 The diagnosis of leptomeningeal metastatic disease has major prognostic and therapeutic implications. We report 13 patients with a radiologically distinct kind of focal, enhancing leptomeningeal lesion on brain MRI that mimics leptomeningeal metastatic disease.\u0000 \u0000 \u0000 \u0000 These patients were assessed at University Health Network (Toronto, Canada) between January 2001 and December 2023.\u0000 \u0000 \u0000 \u0000 Median age was 68 years (range, 55–78 years) and 10 patients were women. All patients had brain MRI including contrast-enhanced T2-weighted fluid attenuation inversion recovery (FLAIR) and T1-weighted spin echo sequences. MRI in all 13 patients showed a focal enhancing lesion located along the leptomeningeal surface of the brain. The MRI exams were reported as possible or likely leptomeningeal metastatic disease for the majority (9/13) of patients. Each lesion was curvilinear rather than sheet-like, and some lesions consisted of multiple connected/branching curvilinear structures with the appearance of abnormal vessels. Some lesions had a visible connection with a nearby cortical vein. The lesions were distinct from normal blood vessels. Follow-up contrast-enhanced brain MRI for 8/13 (62%) patients at a median of 3.9 years (IQR 2.4–6.6 years) showed all lesions were unchanged over time. Another 2/13 (15%) patients had clinical and CT brain follow-up after one year with no evidence of metastatic disease.\u0000 \u0000 \u0000 \u0000 We describe a distinct kind of focal, enhancing leptomeningeal lesion on brain MRI that mimics metastatic disease. These lesions are likely a type of low-flow vascular anomaly. Their curvilinear/branching shape and intense enhancement particularly on T2-weighted FLAIR images distinguishes these lesions from tumor.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141373504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No drug holidays in BRAFV600E glioma patients: an argument for dose reduction of targeted therapies BRAFV600E胶质瘤患者无药假:减少靶向疗法剂量的论据
IF 2.7 Q2 Medicine Pub Date : 2024-05-24 DOI: 10.1093/nop/npae046
Danielle A Bazer, Anna Kolchinski, N. Bush, Jennifer L Clarke, Stephen J Bagley, K. Schreck
Combined BRAF and MEK inhibition is effective for some BRAFV600E altered gliomas, a cancer for which there are few effective therapies. While recent clinical trials demonstrate objective response rates of 30-40%, tolerable adverse event rates are 70-90% and 12-15% patients stop therapy for toxicity. There are no clear guidelines regarding timing and re-initiation of BRAF-targeted therapies following drug holidays. Here, we describe four patients with rapid disease progression during periods of treatment interruption. All patients experienced response upon resumption of targeted therapy. This is a multi-institutional, retrospective review of 4 patients. Three patients were diagnosed with BRAFV600E mutated anaplastic pleomorphic xanthoastrocytoma (aPXA) and one with epithelioid glioblastoma. The age range was 32 to 46; three patients were female and one patient was male. All patients were initially treated with radiation and were subsequently treated with BRAF/MEK inhibitors after disease progression. All patients with aPXA required the targeted therapy to be held due to toxicity and one patient held the therapy prior to transitioning to a novel BRAF-targeted agent. All patients were restarted on BRAF/MEK inhibitors after a drug holiday. Three patients required a dose reduction and all improved clinically following reinitiation. Clinical and radiographic progression may occur rapidly upon holding BRAF-targeted therapy, warranting judicious dose-reductions and minimization of drug holidays
BRAF和MEK联合抑制剂对某些BRAFV600E改变的胶质瘤有效,而这种癌症几乎没有有效的疗法。最近的临床试验表明,客观反应率为 30-40%,但可耐受不良反应率为 70-90%,12-15% 的患者因毒性而停止治疗。目前还没有关于药物休药期后 BRAF 靶向疗法的时机和重新启动的明确指南。在此,我们介绍了四名在治疗中断期间病情迅速进展的患者。所有患者在恢复靶向治疗后都出现了反应。 这是对 4 例患者进行的多机构回顾性研究。 三名患者被诊断为BRAFV600E突变的无性多形黄细胞瘤(aPXA),一名患者被诊断为上皮样胶质母细胞瘤。患者年龄介于 32 岁至 46 岁之间,其中三人为女性,一人为男性。所有患者最初都接受了放射治疗,疾病进展后又接受了BRAF/MEK抑制剂治疗。所有 aPXA 患者都因毒性而需要暂停靶向治疗,其中一名患者在转用新型 BRAF 靶向药物之前暂停了治疗。所有患者都在停药后重新开始使用 BRAF/MEK 抑制剂。三名患者需要减少剂量,重新开始治疗后临床症状均有所改善。 暂停 BRAF 靶向治疗后可能会迅速出现临床和影像学进展,因此需要明智地减少剂量并尽量缩短休药期。
{"title":"No drug holidays in BRAFV600E glioma patients: an argument for dose reduction of targeted therapies","authors":"Danielle A Bazer, Anna Kolchinski, N. Bush, Jennifer L Clarke, Stephen J Bagley, K. Schreck","doi":"10.1093/nop/npae046","DOIUrl":"https://doi.org/10.1093/nop/npae046","url":null,"abstract":"\u0000 \u0000 \u0000 Combined BRAF and MEK inhibition is effective for some BRAFV600E altered gliomas, a cancer for which there are few effective therapies. While recent clinical trials demonstrate objective response rates of 30-40%, tolerable adverse event rates are 70-90% and 12-15% patients stop therapy for toxicity. There are no clear guidelines regarding timing and re-initiation of BRAF-targeted therapies following drug holidays. Here, we describe four patients with rapid disease progression during periods of treatment interruption. All patients experienced response upon resumption of targeted therapy.\u0000 \u0000 \u0000 \u0000 This is a multi-institutional, retrospective review of 4 patients.\u0000 \u0000 \u0000 \u0000 Three patients were diagnosed with BRAFV600E mutated anaplastic pleomorphic xanthoastrocytoma (aPXA) and one with epithelioid glioblastoma. The age range was 32 to 46; three patients were female and one patient was male. All patients were initially treated with radiation and were subsequently treated with BRAF/MEK inhibitors after disease progression. All patients with aPXA required the targeted therapy to be held due to toxicity and one patient held the therapy prior to transitioning to a novel BRAF-targeted agent. All patients were restarted on BRAF/MEK inhibitors after a drug holiday. Three patients required a dose reduction and all improved clinically following reinitiation.\u0000 \u0000 \u0000 \u0000 Clinical and radiographic progression may occur rapidly upon holding BRAF-targeted therapy, warranting judicious dose-reductions and minimization of drug holidays\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141100875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platform trials for rare cancers—A complex innovation to accelerate knowledge 罕见癌症的平台试验--加速知识普及的复杂创新
IF 2.7 Q2 Medicine Pub Date : 2024-05-24 DOI: 10.1093/nop/npae035
Peter Hau, Michael C Frühwald
{"title":"Platform trials for rare cancers—A complex innovation to accelerate knowledge","authors":"Peter Hau, Michael C Frühwald","doi":"10.1093/nop/npae035","DOIUrl":"https://doi.org/10.1093/nop/npae035","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141102499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health-related Quality of Life in surgically treated asymptomatic meningioma patients: a population-based matched cohort study 接受手术治疗的无症状脑膜瘤患者的健康相关生活质量:一项基于人群的匹配队列研究
IF 2.7 Q2 Medicine Pub Date : 2024-05-24 DOI: 10.1093/nop/npae047
O. Näslund, Stina Jakobsson, E. Thurin, T. Skoglund, Jenny Pettersson-Segerlind, B. Brynedal, A. Jakola, Jiri Bartek
Asymptomatic patients with meningiomas are increasingly detected, where management can be challenging in terms of surgery versus watchful waiting. Health-related quality of life (HRQoL) is an important factor in clinical decision making, albeit not greatly studied in this patient group. The aim of this paper is to map the HRQoL among patients with surgically removed asymptomatic meningioma as compared to the general population. Patients with first time surgically treated asymptomatic meningioma between 2007 and 2013 were identified. Patients were invited 2017 to answer a survey regarding different aspects of quality of life, using EuroQoL (EQ)-5D-3L, perceived health, lifestyle, and occupancy. Data from electronic patient records was obtained. The patients were matched based on age and gender with data from the Stockholm Region Public Health Cohort database. There was no difference in EQ-5D-3L or visual analogue scale (VAS) between the patients and their matched controls. Patients and controls experienced ill health to the same extent, but patients felt to a greater extent that this impacted their way of life. In 36% of patients, preoperative occupation was not resumed, mostly due to cognitive symptoms. Additionally, the study suggested social detachment in this cohort, as significantly more patients were living alone and had less emotional support compared to controls. Although surgically treated patients with asymptomatic intracranial meningioma have similar overall HRQoL compared to the general population, surgery has an impact on return to work and cognitive function.
越来越多的无症状脑膜瘤患者被发现,在手术治疗与观察等待方面都面临着挑战。健康相关生活质量(HRQoL)是临床决策的一个重要因素,尽管对这一患者群体的研究不多。本文旨在对手术切除的无症状脑膜瘤患者与普通人群的HRQoL进行比较。 研究人员确定了2007年至2013年间首次接受手术治疗的无症状脑膜瘤患者。2017年,患者应邀回答了一项有关生活质量不同方面的调查,调查采用欧洲生活质量调查(EQ)-5D-3L、健康感知、生活方式和居住情况。从电子病历中获取数据。这些患者的年龄和性别与斯德哥尔摩地区公共卫生队列数据库中的数据相匹配。 患者与匹配的对照组在 EQ-5D-3L 或视觉模拟量表(VAS)方面没有差异。患者和对照组的健康状况不佳程度相同,但患者认为这对其生活方式的影响更大。有 36% 的患者无法恢复术前的职业,主要是由于认知症状。此外,该研究还表明,与对照组相比,该组患者中独居和获得情感支持较少的患者明显增多,这表明他们与社会脱节。 虽然接受过手术治疗的无症状颅内脑膜瘤患者的总体 HRQoL 与普通人群相似,但手术对重返工作岗位和认知功能有影响。
{"title":"Health-related Quality of Life in surgically treated asymptomatic meningioma patients: a population-based matched cohort study","authors":"O. Näslund, Stina Jakobsson, E. Thurin, T. Skoglund, Jenny Pettersson-Segerlind, B. Brynedal, A. Jakola, Jiri Bartek","doi":"10.1093/nop/npae047","DOIUrl":"https://doi.org/10.1093/nop/npae047","url":null,"abstract":"\u0000 \u0000 \u0000 Asymptomatic patients with meningiomas are increasingly detected, where management can be challenging in terms of surgery versus watchful waiting. Health-related quality of life (HRQoL) is an important factor in clinical decision making, albeit not greatly studied in this patient group. The aim of this paper is to map the HRQoL among patients with surgically removed asymptomatic meningioma as compared to the general population.\u0000 \u0000 \u0000 \u0000 Patients with first time surgically treated asymptomatic meningioma between 2007 and 2013 were identified. Patients were invited 2017 to answer a survey regarding different aspects of quality of life, using EuroQoL (EQ)-5D-3L, perceived health, lifestyle, and occupancy. Data from electronic patient records was obtained. The patients were matched based on age and gender with data from the Stockholm Region Public Health Cohort database.\u0000 \u0000 \u0000 \u0000 There was no difference in EQ-5D-3L or visual analogue scale (VAS) between the patients and their matched controls. Patients and controls experienced ill health to the same extent, but patients felt to a greater extent that this impacted their way of life. In 36% of patients, preoperative occupation was not resumed, mostly due to cognitive symptoms. Additionally, the study suggested social detachment in this cohort, as significantly more patients were living alone and had less emotional support compared to controls.\u0000 \u0000 \u0000 \u0000 Although surgically treated patients with asymptomatic intracranial meningioma have similar overall HRQoL compared to the general population, surgery has an impact on return to work and cognitive function.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141100837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing Sleep in Primary Brain Tumor Patients using Smart Wearables and Patient-Reported Data: Feasibility and Interim Analysis of an Observational Study 利用智能可穿戴设备和患者报告数据评估原发性脑肿瘤患者的睡眠情况:一项观察性研究的可行性和中期分析
IF 2.7 Q2 Medicine Pub Date : 2024-05-24 DOI: 10.1093/nop/npae048
Maeve M Pascoe, Alex R. Wollet, Julianie De La Cruz Minyety, Elizabeth Vera, Hope Miller, O. Celiku, H. Leeper, Kelly Fernandez, Jennifer Reyes, Demarrius Young, Alvina A. Acquaye-Mallory, Kendra A. Adegbesan, L. Boris, E. Burton, Claudia P Chambers, Anna Choi, E. Grajkowska, Tricia F. Kunst, Jason Levine, M. Panzer, M. Penas-Prado, V. Pillai, L. Polskin, Jing Wu, Mark R Gilbert, T. Mendoza, Amanda L King, Dorela D. Shuboni-Mulligan, Terri S Armstrong
Sleep-wake disturbances are common and disabling in primary brain tumor (PBT) patients but studies exploring longitudinal data are limited. This study investigates the feasibility and relationship between longitudinal patient-reported outcomes (PROs) and physiologic data collected via smart wearables. Fifty-four PBT patients ≥18 years wore Fitbit smart-wearable devices for 4 weeks, which captured physiologic sleep measures (e.g., total sleep time, wake after sleep onset (WASO)). They completed PROs (Sleep Hygiene Index, PROMIS Sleep-Related Impairment (SRI) and Sleep Disturbance (SD), Morningness-Eveningness Questionnaire (MEQ)) at baseline and 4 weeks. Smart wearable use feasibility (enrollment/attrition, data missingness), clinical characteristics, test consistency, PROs severity, and relationships between PROs and physiologic sleep measures were assessed. The majority (72%) wore their Fitbit for the entire study duration with 89% missing <3 days, no participant withdrawals, and 100% PRO completion. PROMIS SRI/SD and MEQ were all consistent/reliable (Cronbach’s alpha 0.74-0.92). Chronotype breakdown showed 39% morning, 56% intermediate, and only 6% evening types. Moderate-severe SD & SRI were reported in 13% and 17% at baseline, and with significant improvement in SD at 4 weeks (p=0.014). Fitbit-recorded measures showed a correlation at week 4 between WASO and SD (r=0.35, p=0.009) but not with SRI (r=0.24, p=0.08). Collecting sleep data with Fitbits is feasible, PROs are consistent/reliable, >10% of participants had SD and SRI that improved with smart wearable use, and SD was associated with WASO. The skewed chronotype distribution, risk and impact of sleep fragmentation mechanisms warrant further investigation.
睡眠-觉醒障碍是原发性脑肿瘤(PBT)患者常见的致残性疾病,但探索纵向数据的研究却很有限。本研究调查了通过智能可穿戴设备收集的纵向患者报告结果(PROs)和生理数据之间的可行性和关系。 54 名年龄≥18 岁的 PBT 患者佩戴 Fitbit 智能可穿戴设备 4 周,该设备可采集睡眠生理指标(如总睡眠时间、入睡后唤醒时间 (WASO))。他们在基线和 4 周时完成了 PROs(睡眠卫生指数、PROMIS 睡眠相关损害 (SRI) 和睡眠干扰 (SD)、晨间活力问卷 (MEQ))。对智能可穿戴设备使用的可行性(注册/自然减员、数据缺失)、临床特征、测试一致性、PROs 严重程度以及 PROs 与生理学睡眠测量之间的关系进行了评估。 大多数参与者(72%)在整个研究期间都佩戴了 Fitbit,其中 89% 的缺失率为 10%,SD 和 SRI 在使用智能可穿戴设备后有所改善,SD 与 WASO 相关。睡眠碎片机制的时间型分布偏差、风险和影响值得进一步研究。
{"title":"Assessing Sleep in Primary Brain Tumor Patients using Smart Wearables and Patient-Reported Data: Feasibility and Interim Analysis of an Observational Study","authors":"Maeve M Pascoe, Alex R. Wollet, Julianie De La Cruz Minyety, Elizabeth Vera, Hope Miller, O. Celiku, H. Leeper, Kelly Fernandez, Jennifer Reyes, Demarrius Young, Alvina A. Acquaye-Mallory, Kendra A. Adegbesan, L. Boris, E. Burton, Claudia P Chambers, Anna Choi, E. Grajkowska, Tricia F. Kunst, Jason Levine, M. Panzer, M. Penas-Prado, V. Pillai, L. Polskin, Jing Wu, Mark R Gilbert, T. Mendoza, Amanda L King, Dorela D. Shuboni-Mulligan, Terri S Armstrong","doi":"10.1093/nop/npae048","DOIUrl":"https://doi.org/10.1093/nop/npae048","url":null,"abstract":"\u0000 \u0000 \u0000 Sleep-wake disturbances are common and disabling in primary brain tumor (PBT) patients but studies exploring longitudinal data are limited. This study investigates the feasibility and relationship between longitudinal patient-reported outcomes (PROs) and physiologic data collected via smart wearables.\u0000 \u0000 \u0000 \u0000 Fifty-four PBT patients ≥18 years wore Fitbit smart-wearable devices for 4 weeks, which captured physiologic sleep measures (e.g., total sleep time, wake after sleep onset (WASO)). They completed PROs (Sleep Hygiene Index, PROMIS Sleep-Related Impairment (SRI) and Sleep Disturbance (SD), Morningness-Eveningness Questionnaire (MEQ)) at baseline and 4 weeks. Smart wearable use feasibility (enrollment/attrition, data missingness), clinical characteristics, test consistency, PROs severity, and relationships between PROs and physiologic sleep measures were assessed.\u0000 \u0000 \u0000 \u0000 The majority (72%) wore their Fitbit for the entire study duration with 89% missing <3 days, no participant withdrawals, and 100% PRO completion. PROMIS SRI/SD and MEQ were all consistent/reliable (Cronbach’s alpha 0.74-0.92). Chronotype breakdown showed 39% morning, 56% intermediate, and only 6% evening types. Moderate-severe SD & SRI were reported in 13% and 17% at baseline, and with significant improvement in SD at 4 weeks (p=0.014). Fitbit-recorded measures showed a correlation at week 4 between WASO and SD (r=0.35, p=0.009) but not with SRI (r=0.24, p=0.08).\u0000 \u0000 \u0000 \u0000 Collecting sleep data with Fitbits is feasible, PROs are consistent/reliable, >10% of participants had SD and SRI that improved with smart wearable use, and SD was associated with WASO. The skewed chronotype distribution, risk and impact of sleep fragmentation mechanisms warrant further investigation.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141100680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Economic Income And Survival In Patients Affected By Glioblastoma: A Systematic Review And Meta-Analysis 胶质母细胞瘤患者的经济收入与生存期:系统回顾与元分析
IF 2.7 Q2 Medicine Pub Date : 2024-05-11 DOI: 10.1093/nop/npae045
V. Di Nunno, L. Gatto, Marta Aprile, S. Bartolini, A. Tosoni, Enrico Franceschi
Within socio-economic variables, economic income has been associated with the prognosis of patients with glioblastoma. However, studies investigating this issue provided conflicting results We carried out a systematic review and meta-analysis of studies investigating the correlation between economic income and survival in patients with glioblastoma. The inverse variance technique for HR assessment has been employed reporting the random effect model. We included 12 studies for a total of 143303 GBM patients (67463 with high economic income, and 25679 with low economic income). In the overall analysis, lower economic income resulted in poorer survival (pooled HR 1.09, 95%CI, 1.02-1.17, I2=64%). Variables like the type of Health Care System (public, private, or mixed) and the time in which patients have been treated (pre or post-EORTC-NCIC trial 22981/26981, CE.3 protocol advent) did not modify survival on pooled analysis. Economic conditions and income influence the prognosis of patients with glioblastoma. A better understanding of the modifiable barriers leading to treatment disparities in more disadvantaged patients is warranted to make equal oncological care.
在社会经济变量中,经济收入与胶质母细胞瘤患者的预后有关。我们对调查胶质母细胞瘤患者经济收入与生存之间相关性的研究进行了系统回顾和荟萃分析。我们采用了反方差技术进行HR评估,并报告了随机效应模型。 我们共纳入了 12 项研究,共计 143303 名胶质母细胞瘤患者(67463 名经济收入高,25679 名经济收入低)。在总体分析中,经济收入越低,生存率越低(汇总 HR 1.09,95%CI,1.02-1.17,I2=64%)。医疗保健系统的类型(公立、私立或混合)和患者接受治疗的时间(EORTC-NCIC 22981/26981 试验前或试验后,CE.3 方案来临前或试验后)等变量在汇总分析中不会改变生存率。 经济条件和收入会影响胶质母细胞瘤患者的预后。为了实现平等的肿瘤治疗,有必要更好地了解导致弱势患者治疗差异的可改变的障碍。
{"title":"Economic Income And Survival In Patients Affected By Glioblastoma: A Systematic Review And Meta-Analysis","authors":"V. Di Nunno, L. Gatto, Marta Aprile, S. Bartolini, A. Tosoni, Enrico Franceschi","doi":"10.1093/nop/npae045","DOIUrl":"https://doi.org/10.1093/nop/npae045","url":null,"abstract":"\u0000 \u0000 \u0000 Within socio-economic variables, economic income has been associated with the prognosis of patients with glioblastoma. However, studies investigating this issue provided conflicting results\u0000 \u0000 \u0000 \u0000 We carried out a systematic review and meta-analysis of studies investigating the correlation between economic income and survival in patients with glioblastoma. The inverse variance technique for HR assessment has been employed reporting the random effect model.\u0000 \u0000 \u0000 \u0000 We included 12 studies for a total of 143303 GBM patients (67463 with high economic income, and 25679 with low economic income). In the overall analysis, lower economic income resulted in poorer survival (pooled HR 1.09, 95%CI, 1.02-1.17, I2=64%). Variables like the type of Health Care System (public, private, or mixed) and the time in which patients have been treated (pre or post-EORTC-NCIC trial 22981/26981, CE.3 protocol advent) did not modify survival on pooled analysis.\u0000 \u0000 \u0000 \u0000 Economic conditions and income influence the prognosis of patients with glioblastoma. A better understanding of the modifiable barriers leading to treatment disparities in more disadvantaged patients is warranted to make equal oncological care.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140990262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the reporting quality of pediatric neuro-oncology protocols, abstracts and trials:Adherence to the SPIRIT and CONSORT statements 评估儿科神经肿瘤学方案、摘要和试验的报告质量:遵守 SPIRIT 和 CONSORT 声明
IF 2.7 Q2 Medicine Pub Date : 2024-05-11 DOI: 10.1093/nop/npae042
Mr Joshua S Suppree, Miss Sophia Hart, Sumirat M. Keshwara, Miss Sandhya Trichinopoly Krishna, Conor S Gillespie, G. Richardson, M. Mustafa, Conor L Mallucci, Barry Pizer, James Hayden, A. Islim, Michael D Jenkinson, Mr Christopher P Millward
It is of vital importance to comprehensively and transparently report clinical trial activity. The SPIRIT 2013 and CONSORT 2010 statements exist to define items to be reported in clinical trial protocols and randomized controlled trials, respectively. The aim of this methodological review was to assess the reporting quality of pediatric neuro-oncology trial protocols and trial result articles. Published trial protocols and phase II/III trial result articles relating to pediatric brain tumours (published after the introduction of the SPIRIT 2013 statement), were identified through searches of 4 electronic bibliographic databases. The reporting quality of included trial protocols and result articles was assessed against the aforementioned statements. In addition, the CONSORT-A checklist was used to assess the abstracts of trial result articles. Percentage adherence was calculated for each article. 9 trial protocols, 68 phase II trials, and 8 phase III trial results articles were included. Mean adherence of trial protocols to the SPIRIT statement was 76.8% (SD: 0.09). Mean adherence of trial abstracts to CONSORT-A was 67.4% (SD: 0.13) for phase II abstracts and 47.5% (SD: 0.09) for phase III abstracts. Adherence of trial result articles to CONSORT was 71.3% (SD: 0.10) for phase II trials and 70.3% (SD: 0.13) for phase III trials. The reporting quality of pediatric neuro-oncology trial protocols and trial result articles requires improvement, particularly in the areas of randomization and blinding. This is consistent with our previously published findings following similar assessment of reporting quality for adult neuro-oncology trial protocols and result articles.
全面、透明地报告临床试验活动至关重要。SPIRIT 2013 和 CONSORT 2010 声明分别定义了临床试验方案和随机对照试验的报告项目。本方法学综述旨在评估儿科神经肿瘤学试验方案和试验结果文章的报告质量。 通过检索 4 个电子文献数据库,确定了已发表的与小儿脑肿瘤相关的试验方案和 II/III 期试验结果文章(在 SPIRIT 2013 声明发布后发表)。根据上述声明对纳入的试验方案和结果文章的报告质量进行了评估。此外,还使用 CONSORT-A 核对表评估试验结果文章的摘要。计算了每篇文章的遵守百分比。 共纳入了 9 篇试验方案、68 篇 II 期试验和 8 篇 III 期试验结果文章。试验方案对 SPIRIT 声明的平均遵守率为 76.8%(SD:0.09)。II期试验摘要遵守CONSORT-A声明的平均比例为67.4%(标度:0.13),III期试验摘要遵守CONSORT-A声明的平均比例为47.5%(标度:0.09)。II期试验结果文章符合CONSORT的比例为71.3%(SD:0.10),III期试验结果文章符合CONSORT的比例为70.3%(SD:0.13)。 小儿神经肿瘤学试验方案和试验结果文章的报告质量有待提高,尤其是在随机化和盲法方面。这与我们之前对成人神经肿瘤学试验方案和结果文章的报告质量进行类似评估后得出的结果一致。
{"title":"Assessing the reporting quality of pediatric neuro-oncology protocols, abstracts and trials:Adherence to the SPIRIT and CONSORT statements","authors":"Mr Joshua S Suppree, Miss Sophia Hart, Sumirat M. Keshwara, Miss Sandhya Trichinopoly Krishna, Conor S Gillespie, G. Richardson, M. Mustafa, Conor L Mallucci, Barry Pizer, James Hayden, A. Islim, Michael D Jenkinson, Mr Christopher P Millward","doi":"10.1093/nop/npae042","DOIUrl":"https://doi.org/10.1093/nop/npae042","url":null,"abstract":"\u0000 \u0000 \u0000 It is of vital importance to comprehensively and transparently report clinical trial activity. The SPIRIT 2013 and CONSORT 2010 statements exist to define items to be reported in clinical trial protocols and randomized controlled trials, respectively. The aim of this methodological review was to assess the reporting quality of pediatric neuro-oncology trial protocols and trial result articles.\u0000 \u0000 \u0000 \u0000 Published trial protocols and phase II/III trial result articles relating to pediatric brain tumours (published after the introduction of the SPIRIT 2013 statement), were identified through searches of 4 electronic bibliographic databases. The reporting quality of included trial protocols and result articles was assessed against the aforementioned statements. In addition, the CONSORT-A checklist was used to assess the abstracts of trial result articles. Percentage adherence was calculated for each article.\u0000 \u0000 \u0000 \u0000 9 trial protocols, 68 phase II trials, and 8 phase III trial results articles were included. Mean adherence of trial protocols to the SPIRIT statement was 76.8% (SD: 0.09). Mean adherence of trial abstracts to CONSORT-A was 67.4% (SD: 0.13) for phase II abstracts and 47.5% (SD: 0.09) for phase III abstracts. Adherence of trial result articles to CONSORT was 71.3% (SD: 0.10) for phase II trials and 70.3% (SD: 0.13) for phase III trials.\u0000 \u0000 \u0000 \u0000 The reporting quality of pediatric neuro-oncology trial protocols and trial result articles requires improvement, particularly in the areas of randomization and blinding. This is consistent with our previously published findings following similar assessment of reporting quality for adult neuro-oncology trial protocols and result articles.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140987406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pre-operative Stereotactic Radiosurgery for Patients with One to Four Brain Metastases: A Single-Arm Phase 2 Trial Outcome Analysis (NCT03398694) 针对一至四个脑转移灶患者的术前立体定向放射外科治疗:单臂 2 期试验结果分析(NCT03398694)
IF 2.7 Q2 Medicine Pub Date : 2024-05-08 DOI: 10.1093/nop/npae043
N. Agrawal, Jack M. Shireman, K. Shiue, A. Kamer, La Keisha Boyd, Y. Zang, Neel Mukherjee, James C. Miller, C. Kulwin, Aaron A. Cohen-Gadol, Troy Payner, Chih-Ta Lin, Jesse J. Savage, Brandon Lane, Bradley Bohnstedt, T. Lautenschlaeger, Naoyuki Saito, Mitesh Shah, G. Watson, Mahua Dey
Stereotactic radiosurgery (SRS) following surgical resection is the standard of care for patients with symptomatic oligo brain metastasis (BM), however, it is associated with 10-15% local failure. Targeting a resection cavity is imprecise, thus pre-operative radiosurgery where the target is well defined may be superior, however, the efficacy of pre-operative SRS has not yet been tested in a clinical trial. We conducted a phase II, single-arm trial of pre-operative SRS followed by surgical resection in patients with 1-4 symptomatic oligo BMs (NCT03398694) with the primary objective of measuring 6-month local control (LC). SRS was delivered to all patients utilizing gamma knife or linear accelerator as per RTOG-9005 dosing criteria24 based on tumor diameter with the exception that the largest lesion diameter treated was 5 cm with 15 Gy with all SRS treatment given in single fraction dosing. The trial screened 50 patients, 48 patients were treated under the protocol and 32 patients completed the entire follow-up period. Of all the patients who completed the follow-up period, primary endpoint of 6-month LC was 100% (95% CI: 0.891-1.000; p=0.005). Secondary endpoints, presented as medians, were overall-survival (17.6 months), progression-free survival (5.3 months), distant in-brain failure (40.8% at 1 year), leptomeningeal failure (4.8% at 1 year), and radiation necrosis (7.7% at 1 year). Our data confirms superior local control in patients who received pre-operative SRS when compared to historical controls. Further study with a larger randomized cohort of patients is warranted to fully understand the benefits of pre-operative SRS.
手术切除后进行立体定向放射外科治疗(SRS)是治疗无症状少见脑转移瘤(BM)患者的标准方法,但有 10-15% 的局部治疗失败率。瞄准切除腔是不精确的,因此术前放射外科手术如果目标明确,可能会更有优势,但术前 SRS 的疗效尚未在临床试验中得到检验。 我们进行了一项 II 期单臂试验,对 1-4 例有症状的寡BM患者进行术前 SRS,然后进行手术切除(NCT03398694),主要目的是测量 6 个月的局部控制(LC)情况。所有患者均使用伽玛刀或直线加速器进行 SRS 治疗,根据肿瘤直径采用 RTOG-9005 剂量标准24,但最大病灶直径为 5 厘米,治疗剂量为 15 Gy,所有 SRS 治疗均采用单次分次剂量。 试验筛选了 50 名患者,48 名患者按照方案接受了治疗,32 名患者完成了整个随访期。在所有完成随访的患者中,6个月LC的主要终点为100%(95% CI:0.891-1.000;P=0.005)。次要终点(以中位数表示)为总生存期(17.6 个月)、无进展生存期(5.3 个月)、远处脑内衰竭(40.8%,1 年)、脑白质衰竭(4.8%,1 年)和放射性坏死(7.7%,1 年)。 我们的数据证实,与历史对照组相比,术前接受 SRS 治疗的患者局部控制效果更佳。为了充分了解术前 SRS 的益处,我们有必要对更多的随机患者进行进一步研究。
{"title":"Pre-operative Stereotactic Radiosurgery for Patients with One to Four Brain Metastases: A Single-Arm Phase 2 Trial Outcome Analysis (NCT03398694)","authors":"N. Agrawal, Jack M. Shireman, K. Shiue, A. Kamer, La Keisha Boyd, Y. Zang, Neel Mukherjee, James C. Miller, C. Kulwin, Aaron A. Cohen-Gadol, Troy Payner, Chih-Ta Lin, Jesse J. Savage, Brandon Lane, Bradley Bohnstedt, T. Lautenschlaeger, Naoyuki Saito, Mitesh Shah, G. Watson, Mahua Dey","doi":"10.1093/nop/npae043","DOIUrl":"https://doi.org/10.1093/nop/npae043","url":null,"abstract":"\u0000 \u0000 \u0000 Stereotactic radiosurgery (SRS) following surgical resection is the standard of care for patients with symptomatic oligo brain metastasis (BM), however, it is associated with 10-15% local failure. Targeting a resection cavity is imprecise, thus pre-operative radiosurgery where the target is well defined may be superior, however, the efficacy of pre-operative SRS has not yet been tested in a clinical trial.\u0000 \u0000 \u0000 \u0000 We conducted a phase II, single-arm trial of pre-operative SRS followed by surgical resection in patients with 1-4 symptomatic oligo BMs (NCT03398694) with the primary objective of measuring 6-month local control (LC). SRS was delivered to all patients utilizing gamma knife or linear accelerator as per RTOG-9005 dosing criteria24 based on tumor diameter with the exception that the largest lesion diameter treated was 5 cm with 15 Gy with all SRS treatment given in single fraction dosing.\u0000 \u0000 \u0000 \u0000 The trial screened 50 patients, 48 patients were treated under the protocol and 32 patients completed the entire follow-up period. Of all the patients who completed the follow-up period, primary endpoint of 6-month LC was 100% (95% CI: 0.891-1.000; p=0.005). Secondary endpoints, presented as medians, were overall-survival (17.6 months), progression-free survival (5.3 months), distant in-brain failure (40.8% at 1 year), leptomeningeal failure (4.8% at 1 year), and radiation necrosis (7.7% at 1 year).\u0000 \u0000 \u0000 \u0000 Our data confirms superior local control in patients who received pre-operative SRS when compared to historical controls. Further study with a larger randomized cohort of patients is warranted to fully understand the benefits of pre-operative SRS.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140999693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Brain Cancer Care Coordinators on Healthcare Utilisation and Outcomes in Patients with Glioblastoma 脑癌护理协调员对胶质母细胞瘤患者医疗服务利用率和疗效的影响
IF 2.7 Q2 Medicine Pub Date : 2024-05-04 DOI: 10.1093/nop/npae030
Martin Hong, Lucy Leigh, Connor Ballinger, Penny Reeves, Alisha Gooley, Sandy Nixon, Chris Paul, J. Lynam
Cancer care coordinators (CCCs) are recognised as having an important role in patients’ and carers’ cancer journey. However, there are no studies investigating the impact of CCCs on quantitative outcomes. We performed a retrospective cohort study investigating the impact of Brain Cancer Care Coordinators (BCCCs) on health service resource use and survival in patients with glioblastoma. All patients diagnosed with glioblastoma between 2012 and 2019 in Hunter New England Local Health District, Australia (HNELHD) were included and the patients were divided into two cohorts: before and after introduction of the BCCC. Any patient diagnosed in 2016, during the introduction of the BCCC, were excluded. Main outcomes assessed were overall survival, health service resource use, odds of being admitted to hospital after emergency presentation, and cost-offset analysis to examine the economic implications of BCCCs. A total of 187 patients were included. There were no significant differences in overall survival between the two groups (mOS 12.0 vs 11.16 months, HR 0.95). However, there was a reduction in the number of ED presentations and admissions. This was associated with a 24% reduction in aggregate length of stay with the BCCC. There was no statistically significant difference in mean patient costs, however our hospital may have saved over AUD$500,000 with BCCCs. The introduction of BCCC did not improve survival but appeared to be associated with reduced health resource utilisation. This study provides economic justification, in addition to established quality of life improvements, to support the presence of BCCCs.
癌症护理协调员(CCCs)被认为在患者和护理者的癌症治疗过程中发挥着重要作用。然而,目前还没有研究调查癌症护理协调员对量化结果的影响。我们进行了一项回顾性队列研究,调查脑癌护理协调员(BCCs)对胶质母细胞瘤患者医疗服务资源使用和存活率的影响。 研究纳入了澳大利亚猎人新英格兰地方卫生区(HNELHD)2012年至2019年期间确诊的所有胶质母细胞瘤患者,并将患者分为两个队列:引入BCC之前和之后。任何在2016年(BCC引入期间)确诊的患者均被排除在外。评估的主要结果包括总体生存率、医疗服务资源使用情况、急诊后入院的几率,以及成本抵消分析,以研究 BCCC 的经济影响。 共纳入了187名患者。两组患者的总生存期无明显差异(mOS 12.0 个月 vs 11.16 个月,HR 0.95)。不过,急诊室就诊和入院人数有所减少。这与 BCCC 的总住院时间减少 24% 有关。患者的平均费用在统计学上没有明显差异,但我们医院使用 BCCC 可能节省了 50 多万澳元。 BCCC 的引入并没有提高生存率,但似乎与医疗资源利用率的降低有关。除了已经确定的生活质量改善之外,本研究还提供了经济方面的理由来支持 BCCC 的存在。
{"title":"The Impact of Brain Cancer Care Coordinators on Healthcare Utilisation and Outcomes in Patients with Glioblastoma","authors":"Martin Hong, Lucy Leigh, Connor Ballinger, Penny Reeves, Alisha Gooley, Sandy Nixon, Chris Paul, J. Lynam","doi":"10.1093/nop/npae030","DOIUrl":"https://doi.org/10.1093/nop/npae030","url":null,"abstract":"\u0000 \u0000 \u0000 Cancer care coordinators (CCCs) are recognised as having an important role in patients’ and carers’ cancer journey. However, there are no studies investigating the impact of CCCs on quantitative outcomes. We performed a retrospective cohort study investigating the impact of Brain Cancer Care Coordinators (BCCCs) on health service resource use and survival in patients with glioblastoma.\u0000 \u0000 \u0000 \u0000 All patients diagnosed with glioblastoma between 2012 and 2019 in Hunter New England Local Health District, Australia (HNELHD) were included and the patients were divided into two cohorts: before and after introduction of the BCCC. Any patient diagnosed in 2016, during the introduction of the BCCC, were excluded. Main outcomes assessed were overall survival, health service resource use, odds of being admitted to hospital after emergency presentation, and cost-offset analysis to examine the economic implications of BCCCs.\u0000 \u0000 \u0000 \u0000 A total of 187 patients were included. There were no significant differences in overall survival between the two groups (mOS 12.0 vs 11.16 months, HR 0.95). However, there was a reduction in the number of ED presentations and admissions. This was associated with a 24% reduction in aggregate length of stay with the BCCC. There was no statistically significant difference in mean patient costs, however our hospital may have saved over AUD$500,000 with BCCCs.\u0000 \u0000 \u0000 \u0000 The introduction of BCCC did not improve survival but appeared to be associated with reduced health resource utilisation. This study provides economic justification, in addition to established quality of life improvements, to support the presence of BCCCs.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disease burden and healthcare utilization in pediatric low-grade glioma: a United States retrospective study of linked claims and electronic health records 小儿低级别胶质瘤的疾病负担和医疗保健利用情况:美国对关联索赔和电子健康记录的回顾性研究
IF 2.7 Q2 Medicine Pub Date : 2024-04-27 DOI: 10.1093/nop/npae037
Susan Zelt, Tabitha Cooney, Sandie Yu, Shailaja Daral, Blake Krebs, Riddhi Markan, Peter Manley, Mark Kieran, Sandya Govinda Raju
Despite high long-term survival rates, pediatric low-grade gliomas (pLGGs) are linked with significant tumor- and treatment-associated morbidities that may persist throughout life. The aims of this descriptive cross-sectional pilot study were to characterize health conditions among a cohort of patients with pLGG and explore the feasibility of quantifying disease burden and healthcare resource utilization (HRU). Optum® Market Clarity Data were used to identify patients aged ≤18 years with an ICD-10 code for brain neoplasm, ≥1 physician notes, and with evidence of pLGG recorded between January 1, 2017 – June 30, 2018. Outcomes including health characteristics, HRU, medications, and procedures were assessed at six-month intervals over 36 months. 154 patients were identified with pLGG and over half experienced headache/migraine, respiratory infection, pain, or behavioral issues during the 36-month study period. The most common comorbidities were ocular/visual (including blindness), mental health disorders, seizure, and behavioral/cognition disorders. Most symptoms and comorbidities persisted or increased during the study period, indicating long-term health deficits. HRU, including specialty care visits, filled prescriptions, and administered medications, was common; 74% of patients had prescriptions for anti-infectives, 56% antiemetics, and 52% requiring pain or fever relief. Sixty-five percent of patients underwent treatment to control their pLGG, the most common being brain surgery. Little decline was observed in medication use during the study period. Patients with pLGG have complex healthcare needs requiring high HRU, often over a long time. Patients need to be optimally managed to minimize disease- and treatment-related burden and HRU.
尽管小儿低级别胶质瘤(pLGGs)的长期存活率很高,但其与肿瘤和治疗相关的重大病症可能会持续终生。这项描述性横断面试点研究的目的是描述一组 pLGG 患者的健康状况,并探索量化疾病负担和医疗资源利用率 (HRU) 的可行性。 研究使用 Optum® Market Clarity 数据来识别年龄≤18 岁、ICD-10 编码为脑肿瘤、医生记录≥1 份且在 2017 年 1 月 1 日至 2018 年 6 月 30 日期间记录有 pLGG 证据的患者。在 36 个月内,每隔 6 个月对包括健康特征、HRU、药物和手术在内的结果进行评估。 在 36 个月的研究期间,154 名患者被确认患有 pLGG,超过一半的患者出现头痛/偏头痛、呼吸道感染、疼痛或行为问题。最常见的合并症是眼部/视觉(包括失明)、精神疾病、癫痫发作和行为/认知障碍。大多数症状和并发症在研究期间持续存在或有所增加,表明存在长期健康缺陷。包括专科就诊、开具处方和用药在内的 HRU 很常见;74% 的患者开具了抗感染药处方,56% 的患者开具了止吐药处方,52% 的患者需要止痛或退烧。65%的患者接受了控制 pLGG 的治疗,其中最常见的是脑部手术。在研究期间,观察到的用药量几乎没有下降。 pLGG 患者有复杂的医疗保健需求,往往需要长期服用大量 HRU。需要对患者进行最佳管理,以最大限度地减少疾病和治疗相关的负担及 HRU。
{"title":"Disease burden and healthcare utilization in pediatric low-grade glioma: a United States retrospective study of linked claims and electronic health records","authors":"Susan Zelt, Tabitha Cooney, Sandie Yu, Shailaja Daral, Blake Krebs, Riddhi Markan, Peter Manley, Mark Kieran, Sandya Govinda Raju","doi":"10.1093/nop/npae037","DOIUrl":"https://doi.org/10.1093/nop/npae037","url":null,"abstract":"\u0000 \u0000 \u0000 Despite high long-term survival rates, pediatric low-grade gliomas (pLGGs) are linked with significant tumor- and treatment-associated morbidities that may persist throughout life. The aims of this descriptive cross-sectional pilot study were to characterize health conditions among a cohort of patients with pLGG and explore the feasibility of quantifying disease burden and healthcare resource utilization (HRU).\u0000 \u0000 \u0000 \u0000 Optum® Market Clarity Data were used to identify patients aged ≤18 years with an ICD-10 code for brain neoplasm, ≥1 physician notes, and with evidence of pLGG recorded between January 1, 2017 – June 30, 2018. Outcomes including health characteristics, HRU, medications, and procedures were assessed at six-month intervals over 36 months.\u0000 \u0000 \u0000 \u0000 154 patients were identified with pLGG and over half experienced headache/migraine, respiratory infection, pain, or behavioral issues during the 36-month study period. The most common comorbidities were ocular/visual (including blindness), mental health disorders, seizure, and behavioral/cognition disorders. Most symptoms and comorbidities persisted or increased during the study period, indicating long-term health deficits. HRU, including specialty care visits, filled prescriptions, and administered medications, was common; 74% of patients had prescriptions for anti-infectives, 56% antiemetics, and 52% requiring pain or fever relief. Sixty-five percent of patients underwent treatment to control their pLGG, the most common being brain surgery. Little decline was observed in medication use during the study period.\u0000 \u0000 \u0000 \u0000 Patients with pLGG have complex healthcare needs requiring high HRU, often over a long time. Patients need to be optimally managed to minimize disease- and treatment-related burden and HRU.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140652048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Neuro-oncology practice
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1