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Incidence and outcome of pseudoprogression after radiation therapy in glioblastoma patients: a cohort study 胶质母细胞瘤患者放射治疗后假性进展的发生率和结果:一项队列研究
Q2 CLINICAL NEUROLOGY Pub Date : 2023-10-03 DOI: 10.1093/nop/npad063
Hanne Blakstad, Eduardo Erasmo Mendoza Mireles, Liv Cathrine Heggebø, Henriette Magelssen, Mette Sprauten, Tom Børge Johannesen, Einar Vik-Mo, Henning Leske, Pitt Niehusmann, Karoline Skogen, Eirik Helseth, Kyrre Eeg Emblem, Petter Brandal
Abstract Background Differentiating post-radiation MRI changes from progressive disease (PD) in glioblastoma (GBM) patients represents a major challenge. The clinical problem is two-sided; avoid termination of effective therapy in case of pseudoprogression (PsP) and continuation of ineffective therapy in case of PD. We retrospectively assessed incidence, management, and prognostic impact of PsP and analyzed factors associated with PsP in a GBM patient cohort. Methods Consecutive GBM patients diagnosed in South-Eastern Norway Health Region from 2015 to 2018 who had received RT and follow-up MRI were included. Tumor, patient, and treatment characteristics were analyzed in relationship to re-evaluated MRI examinations at three and six months post-radiation using Response Assessment in Neuro-Oncology criteria. Results A total of 284 patients were included in the study. PsP incidence three and six months post-radiation was 19.4% and 7.0%, respectively. In adjusted analyses, methylated O 6-methylguanine-DNA methyltransferase (MGMT) promoter and absence of neurological deterioration were associated with PsP at both three (p<0.001 and p=0.029, respectively) and six months (p=0.045 and p=0.034, respectively) post-radiation. For patients retrospectively assessed as PD three months post-radiation, there was no survival benefit of treatment change (p=0.838). Conclusion PsP incidence was similar to previous reports. In addition to the previously described correlation of methylated MGMT promoter with PsP, we also found that absence of neurological deterioration significantly correlated with PsP. Continuation of temozolomide courses did not seem to compromise survival for patients with PD at three months post-radiation; therefore, we recommend continuing adjuvant temozolomide courses in case of inconclusive MRI findings.
背景:鉴别胶质母细胞瘤(GBM)患者放射后MRI变化与进展性疾病(PD)是一个重大挑战。临床问题是双面的;避免在假性进展(PsP)的情况下终止有效的治疗和在PD的情况下继续无效的治疗。我们回顾性地评估了一组GBM患者中PsP的发病率、治疗和预后影响,并分析了与PsP相关的因素。方法纳入2015 - 2018年挪威东南部卫生区诊断为GBM并接受RT和随访MRI的连续患者。肿瘤、患者和治疗特征分析与放疗后3个月和6个月的MRI检查的关系,使用神经肿瘤学标准中的反应评估。结果共纳入284例患者。放疗后3个月和6个月PsP发病率分别为19.4%和7.0%。在校正分析中,甲基化的O - 6-甲基鸟嘌呤- dna甲基转移酶(MGMT)启动子和没有神经退化与放射后3个月(p<0.001和p=0.029)和6个月(p=0.045和p=0.034)的PsP相关。对于放疗后3个月回顾性评估为PD的患者,治疗改变没有生存获益(p=0.838)。结论本组PsP发病率与既往报道相似。除了先前描述的甲基化MGMT启动子与PsP的相关性外,我们还发现神经退化的缺失与PsP显著相关。替莫唑胺疗程的延续似乎不会影响PD患者放疗后3个月的生存;因此,我们建议在MRI结果不确定的情况下继续使用替莫唑胺辅助疗程。
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引用次数: 0
Gender balance and suitable positive actions to promote gender equality among health care professionals in neuro-oncology: the EANO positive action initiative 性别平衡和促进神经肿瘤学保健专业人员性别平等的适当积极行动:EANO积极行动倡议
Q2 CLINICAL NEUROLOGY Pub Date : 2023-10-03 DOI: 10.1093/nop/npad064
Emilie Le Rhun, Florien Boele, Giuseppe Minniti, Norbert Galldiks, Martin Taphoorn, Karin Piil, Roberta Rudà, Simone P Niclou, Marjolein Geurts, Matthias Preusser, Michael Weller, Susan C Short, Linda Dirven
Abstract Background The proportion of women among healthcare and biomedical research professionals in neuro-oncology is growing. With changes in cultural expectations and work-life balance considerations, more men aspire to nonfull-time jobs, yet, leadership positions remain dominated by men. Methods The European Association of Neuro-Oncology (EANO) disparity committee carried out a digital survey to explore gender balance and actions suitable to promote gender equality. The survey was distributed among EANO members in 2021, with responses analyzed descriptively. Results In total, 262 participants completed the survey (141 women, 53.8%; median age 43). Respondents were neurosurgeons (68, 26.0%); neurologists (67, 25.6%), medical oncologists (43, 16.4%), or other healthcare or research professionals; 208 participants (79.4%) worked full-time. Positive action to enforce the role of women in neuro-oncology was deemed necessary by 180 participants (68.7%), but only 28 participants (10.7%) agreed that women only should be promoted until gender balance is reached. A majority of respondents (162, 61.8%) felt that women with an equivalent CV should be prioritized over men to reach gender balance. If in the future the balance favored women at higher positions, 112 respondents (42.7%) agreed to apply positive action for men. The top indicators considered relevant to measure gender balance were: salary for similar positions (183/228, 80.3%), paid overtime (176/228, 77.2%), number of permanent positions (164/228, 71.9%), protected time for research (161/227, 70.9%), and training opportunities (157/227, 69.2%). Conclusions Specific indicators may help to measure and promote gender balance and should be considered for implementation among healthcare professionals in neuro-oncology.
背景在神经肿瘤学的医疗保健和生物医学研究专业人员中,女性的比例正在增长。随着文化期望的变化和工作与生活平衡的考虑,越来越多的男性渴望非全职工作,然而,领导职位仍然由男性主导。方法欧洲神经肿瘤协会(EANO)性别差异委员会开展数字调查,探讨性别平衡及促进性别平等的措施。该调查于2021年在EANO成员中进行了分发,并对回复进行了描述性分析。结果共262人完成调查,其中女性141人,占53.8%;平均年龄43岁)。调查对象为神经外科医生(68人,26.0%);神经科医生(67人,25.6%)、肿瘤内科医生(43人,16.4%)或其他医疗保健或研究专业人员;208名参与者(79.4%)全职工作。180名参与者(68.7%)认为有必要采取积极行动加强女性在神经肿瘤学中的作用,但只有28名参与者(10.7%)同意只有在达到性别平衡之前才应该提升女性。大多数受访者(162,61.8%)认为,为了实现性别平衡,应该优先考虑拥有同等简历的女性,而不是男性。112名受访者(42.7%)同意,如果未来天平偏向高位女性,将对男性采取积极行动。被认为与衡量性别平衡相关的最重要指标是:类似职位的工资(183/228,80.3%)、加班费(176/228,77.2%)、固定职位数量(164/228,71.9%)、受保护的研究时间(161/227,70.9%)和培训机会(157/227,69.2%)。结论特定的指标可能有助于衡量和促进性别平衡,应考虑在神经肿瘤医护人员中实施。
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引用次数: 0
Role of Hypofractionated Stereotactic Radiotherapy for Primary Optic Nerve Sheath Meningioma 低分割立体定向放射治疗原发性视神经鞘脑膜瘤的作用
Q2 CLINICAL NEUROLOGY Pub Date : 2023-10-03 DOI: 10.1093/nop/npad060
İrem Koç, Sezin Yüce Sarı, Gözde Yazıcı, Yasemin Kapucu, Hayyam Kıratlı, Faruk Zorlu
Abstract Background Optic nerve sheath meningiomas (ONSM) are rare tumors potentially causing visual deficits. This study aims to report the anatomic and visual outcomes of patients with primary ONSM treated with hypofractionated stereotactic radiotherapy (HF-SRT). Methods Data of 36 patients treated with HF-SRT between 2008 and 2019 were retrospectively collected. The clinical target volume (CTV) was equal to the gross tumor volume and a 2 mm was added for the planning target volume. All responses other than progression were accepted as local control (LC). The VA grading was performed under 3 groups to provide an even distribution; 20/400 or worse, 20/40-20/400, and 20/40 or better. Results Median HF-SRT dose was 25 Gy and the median CTV was 1.94 cc. After a median of 106 months of follow-up, the tumor regressed in 23 (64%), was stable in 9 (25%), and progressed in 4 (11%) eyes. The overall rate of LC was 89% with 2-, 5-, 10-, and 15-year rate of 100%, 94%, 84%, and 84%, respectively. Treatment-related late toxicity rate was 11%. The VA was stable in 27 (75%) eyes, improved in 5 (14%) eyes, and worsened in 4 (11%) eyes, respectively, after HF-SRT. Female gender was the only independent predictor of an improved VA. Conclusions Hypofractionated stereotactic radiotherapy is a safe and satisfactory treatment option for primary ONSM without severe toxicity. It may be advisable to commence treatment before an established visual deficit of 20/400 or worse occurs, to make the most of the functional benefit.
视神经鞘脑膜瘤(ONSM)是一种罕见的具有潜在视觉缺陷的肿瘤。本研究旨在报告原发性ONSM患者接受低分割立体定向放疗(HF-SRT)治疗的解剖和视觉结果。方法回顾性收集2008 ~ 2019年接受HF-SRT治疗的36例患者资料。临床靶体积(CTV)与肿瘤总体积相等,计划靶体积增加2mm。除进展外的所有反应均被接受为局部控制(LC)。为使VA分布均匀,将VA分为3组;20/400或更差,20/40-20/400,20/40或更好。结果中位HF-SRT剂量为25 Gy,中位CTV为1.94 cc。中位随访106个月后,肿瘤消退23例(64%),稳定9例(25%),进展4例(11%)。总LC率为89%,2年、5年、10年和15年的LC率分别为100%、94%、84%和84%。治疗相关的晚期毒性发生率为11%。HF-SRT后,27只(75%)眼的VA稳定,5只(14%)眼VA改善,4只(11%)眼VA恶化。结论低分割立体定向放疗对原发性ONSM是一种安全、满意的治疗选择,且无严重毒性。在视力下降到20/400或更差之前开始治疗是明智的,以使功能获益最大化。
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引用次数: 0
Childhood, adolescent, and adult primary brain and central nervous system tumor statistics for practicing healthcare providers in neuro-oncology, CBTRUS 2015-2019 CBTRUS 2015-2019神经肿瘤学执业医疗保健提供者的儿童、青少年和成人原发性脑和中枢神经系统肿瘤统计数据
Q2 CLINICAL NEUROLOGY Pub Date : 2023-09-28 DOI: 10.1093/nop/npad061
Mackenzie Price, Katherine Ryan, Madison L Shoaf, Corey Neff, J Bryan Iorgulescu, Daniel B Landi, Gino Cioffi, Kristin A Waite, Carol Kruchko, Jill S Barnholtz-Sloan, Quinn T Ostrom
Abstract Background The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control and Prevention (CDC) and National Cancer Institute (NCI), is the largest aggregation of histopathology-specific population-based data for primary brain and other central nervous system (CNS) in the US. CBTRUS publishes an annual statistical report which provides critical reference data for the broad neuro-oncology community. Here we summarize the key findings from the 2022 CBTRUS annual statistical report for healthcare providers. Methods Incidence data were obtained from the CDC’s National Program of Cancer Registries (NPCR) and NCI’s Surveillance, Epidemiology, and End Results Program for 52 central cancer registries (CCRs). Survival data were obtained from 42 NPCR CCRs. All rates are per 100,000 and age-adjusted using the 2000 US standard population. Overall median survival was estimated using Kaplan-Meier models. Survival data for selected molecularly-defined histopathologies are from the National Cancer Database. Mortality data are from the National Vital Statistics System. Results The average annual age-adjusted incidence rate of all primary brain and other CNS tumors was 24.25/100,000. Incidence was higher in females and non-Hispanics. The most commonly occurring malignant and predominately non-malignant tumors was glioblastoma (14% of all primary brain tumors) and meningioma (39% of all primary brain tumors), respectively. Mortality rates and overall median survival varied by age, sex, and histopathology. Conclusions This summary describes the most up-to-date population-based incidence, mortality, and survival, of primary brain and other CNS tumors in the US, and aims to serve as a concise resource for neuro-oncology providers.
背景:美国中央脑肿瘤登记处(CBTRUS)与美国疾病控制与预防中心(CDC)和国家癌症研究所(NCI)合作,是美国最大的基于原发性脑和其他中枢神经系统(CNS)的组织病理学特异性人群数据集合。CBTRUS每年发布一份统计报告,为广泛的神经肿瘤学社区提供重要的参考数据。在这里,我们总结了2022年CBTRUS年度统计报告中针对医疗保健提供者的主要发现。方法从CDC的国家癌症登记项目(NPCR)和NCI的监测、流行病学和最终结果项目中获得52个中心癌症登记项目(CCRs)的发病率数据。从42例NPCR ccr中获得生存数据。所有的比率都是每10万人,并使用2000年美国标准人口进行年龄调整。使用Kaplan-Meier模型估计总中位生存期。选定的分子定义的组织病理学的生存数据来自国家癌症数据库。死亡率数据来自国家生命统计系统。结果原发性脑及其他中枢神经系统肿瘤经年龄调整后的年平均发病率为24.25/10万。女性和非西班牙裔的发病率更高。最常见的恶性和非恶性肿瘤分别是胶质母细胞瘤(占所有原发性脑肿瘤的14%)和脑膜瘤(占所有原发性脑肿瘤的39%)。死亡率和总体中位生存期因年龄、性别和组织病理学而异。结论:本综述描述了美国原发性脑肿瘤和其他中枢神经系统肿瘤最新的基于人群的发病率、死亡率和生存率,旨在为神经肿瘤学提供者提供简明的资源。
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引用次数: 0
Primary brain tumor representation in the post-traumatic growth literature: A scoping review 原发性脑肿瘤在创伤后生长文献中的表现:范围综述
Q2 CLINICAL NEUROLOGY Pub Date : 2023-09-19 DOI: 10.1093/nop/npad058
Julia K Brechbiel, Kelcie D Willis, Morgan P Reid, Autumn Lanoye, Farah J Aslanzadeh, Amber M Fox, Sarah Ellen Braun, Ashlee R Loughan
Abstract Background Post-traumatic growth (PTG) has been extensively explored within general oncology, yet little is known about the experience of PTG in neuro-oncology. This study aimed to determine the representation of patients with primary brain tumors (PBT) in the PTG literature. Methods PsycINFO, PubMed, and CINAHL were systematically searched from inception to December 2022. Search terms were related to personal growth and positive reactions to cancer. Articles were first screened by titles and abstracts, then full texts were reviewed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses method. Results A total of 382 articles met the inclusion criteria. Of those, 13 included patients with PBT. Over 100 000 cancer patients were represented, with 0.79% having a PBT. Most research focused on low-grade gliomas. PTG negatively correlated with post-traumatic stress symptoms and avoidant coping. In the sole longitudinal study, patients with PBT demonstrated improved PTG after 1 year. Three quasi-experimental studies investigated the effect of mindfulness-based interventions with mixed-cancer samples and demonstrated improvement in PTG. Conclusions The inclusion rate of patients with PBT in the PTG literature was significantly lower than the population prevalence rate (1.3% of cancer diagnoses). Relatively few studies focused exclusively on how patients with PBT experience PTG (k = 5), and those that did only included low-grade glioma. The experience of PTG in those with high-grade glioma remains unknown. Patients with PBT are scarcely included in research on PTG interventions. Few studies examined the relationship between PTG and medical, cognitive, or psychological characteristics. Our understanding of the PTG experience in neuro-oncology remains extremely limited.
背景创伤后生长(PTG)在普通肿瘤学中已经得到了广泛的研究,但在神经肿瘤学中却知之甚少。本研究旨在确定原发性脑肿瘤(PBT)患者在PTG文献中的代表性。方法系统检索PsycINFO、PubMed、CINAHL自成立至2022年12月。搜索词与个人成长和对癌症的积极反应有关。文章首先通过标题和摘要进行筛选,然后使用系统评价和元分析方法的首选报告项目对全文进行审查。结果共有382篇文章符合纳入标准。其中13例为PBT患者。超过10万名癌症患者,0.79%的人有PBT。大多数研究集中在低级别胶质瘤上。PTG与创伤后应激症状和回避性应对呈负相关。在唯一的纵向研究中,PBT患者在1年后表现出改善的PTG。三个准实验研究调查了基于正念的干预对混合癌症样本的影响,并证明了PTG的改善。结论PBT患者在PTG文献中的纳入率明显低于人群患病率(占癌症诊断的1.3%)。相对较少的研究专门关注PBT患者如何经历PTG (k = 5),而那些只包括低级别胶质瘤的研究。PTG在高级别胶质瘤患者中的应用尚不清楚。PBT患者很少被纳入PTG干预研究。很少有研究调查ptsd与医学、认知或心理特征之间的关系。我们对PTG在神经肿瘤学中的应用经验的了解仍然非常有限。
{"title":"Primary brain tumor representation in the post-traumatic growth literature: A scoping review","authors":"Julia K Brechbiel, Kelcie D Willis, Morgan P Reid, Autumn Lanoye, Farah J Aslanzadeh, Amber M Fox, Sarah Ellen Braun, Ashlee R Loughan","doi":"10.1093/nop/npad058","DOIUrl":"https://doi.org/10.1093/nop/npad058","url":null,"abstract":"Abstract Background Post-traumatic growth (PTG) has been extensively explored within general oncology, yet little is known about the experience of PTG in neuro-oncology. This study aimed to determine the representation of patients with primary brain tumors (PBT) in the PTG literature. Methods PsycINFO, PubMed, and CINAHL were systematically searched from inception to December 2022. Search terms were related to personal growth and positive reactions to cancer. Articles were first screened by titles and abstracts, then full texts were reviewed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses method. Results A total of 382 articles met the inclusion criteria. Of those, 13 included patients with PBT. Over 100 000 cancer patients were represented, with 0.79% having a PBT. Most research focused on low-grade gliomas. PTG negatively correlated with post-traumatic stress symptoms and avoidant coping. In the sole longitudinal study, patients with PBT demonstrated improved PTG after 1 year. Three quasi-experimental studies investigated the effect of mindfulness-based interventions with mixed-cancer samples and demonstrated improvement in PTG. Conclusions The inclusion rate of patients with PBT in the PTG literature was significantly lower than the population prevalence rate (1.3% of cancer diagnoses). Relatively few studies focused exclusively on how patients with PBT experience PTG (k = 5), and those that did only included low-grade glioma. The experience of PTG in those with high-grade glioma remains unknown. Patients with PBT are scarcely included in research on PTG interventions. Few studies examined the relationship between PTG and medical, cognitive, or psychological characteristics. Our understanding of the PTG experience in neuro-oncology remains extremely limited.","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135060809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraoperative language mapping guided by real-time visualization of gamma band modulation electrocorticograms: case report and proof of concept 伽玛波段调制皮质电图实时可视化引导的术中语言映射:病例报告和概念证明
Q2 CLINICAL NEUROLOGY Pub Date : 2023-09-18 DOI: 10.1093/nop/npad059
Kyle R Noll, Priscella Asman, Israt Tasnim, Matthew Hall, Katherine Connelly, Chandra Swamy, Chibawanye Ene, Sudhakar Tummala, Roxana M Grasu, Ho-Ling Liu, Vinodh A Kumar, Matthew Muir, Sarah Prinsloo, Hayley Michener, Jeffrey S Wefel, Nuri F Ince, Sujit S Prabhu
Abstract Background Electrocorticography (ECoG) language mapping is often performed extraoperatively, frequently involves offline processing, and relationships with direct cortical stimulation (DCS) remain variable. We sought to determine the feasibility and preliminary utility of an intraoperative language mapping approach guided by real-time visualization of electrocorticograms. Methods A patient with astrocytoma underwent awake craniotomy with intraoperative language mapping, utilizing a dual iPad stimulus presentation system coupled to a real-time neural signal processing platform capable of both ECoG recording and delivery of DCS. Gamma band modulations in response to 4 language tasks at each electrode were visualized in real-time. Next, DCS was conducted for each neighboring electrode pair during language tasks. Results All language tasks resulted in strongest heat map activation at an electrode pair in the anterior to mid superior temporal gyrus. Consistent speech arrest during DCS was observed for Object and Action naming tasks at these same electrodes, indicating good correspondence with ECoG heat map recordings. This region corresponded well with posterior language representation via preoperative functional MRI. Conclusions Intraoperative real-time visualization of language task-based ECoG gamma band modulation is feasible and may help identify targets for DCS. If validated, this may improve the efficiency and accuracy of intraoperative language mapping.
脑皮层电图(ECoG)语言映射通常在手术外进行,通常涉及离线处理,并且与直接皮层刺激(DCS)的关系仍然是可变的。我们试图确定术中语言映射方法的可行性和初步效用,该方法由脑皮质电图实时可视化指导。方法1例星形细胞瘤患者行清醒开颅术,术中语言定位,采用双iPad刺激呈现系统,结合实时神经信号处理平台,可同时记录ECoG和传送DCS。每个电极上响应4种语言任务的伽马波段调制实时可视化。然后,对语言任务中相邻的电极对进行DCS。结果在所有语言任务中,颞上回前至中上回电极对的热图激活最强。在这些相同的电极上,观察到DCS期间对象和动作命名任务的一致言语停止,表明与ECoG热图记录有良好的对应关系。通过术前功能性MRI检查,该区域与后验语言表征吻合良好。结论术中基于语言任务的脑电伽马波段调制实时可视化是可行的,有助于识别DCS的靶点。如果得到验证,这可能会提高术中语言映射的效率和准确性。
{"title":"Intraoperative language mapping guided by real-time visualization of gamma band modulation electrocorticograms: case report and proof of concept","authors":"Kyle R Noll, Priscella Asman, Israt Tasnim, Matthew Hall, Katherine Connelly, Chandra Swamy, Chibawanye Ene, Sudhakar Tummala, Roxana M Grasu, Ho-Ling Liu, Vinodh A Kumar, Matthew Muir, Sarah Prinsloo, Hayley Michener, Jeffrey S Wefel, Nuri F Ince, Sujit S Prabhu","doi":"10.1093/nop/npad059","DOIUrl":"https://doi.org/10.1093/nop/npad059","url":null,"abstract":"Abstract Background Electrocorticography (ECoG) language mapping is often performed extraoperatively, frequently involves offline processing, and relationships with direct cortical stimulation (DCS) remain variable. We sought to determine the feasibility and preliminary utility of an intraoperative language mapping approach guided by real-time visualization of electrocorticograms. Methods A patient with astrocytoma underwent awake craniotomy with intraoperative language mapping, utilizing a dual iPad stimulus presentation system coupled to a real-time neural signal processing platform capable of both ECoG recording and delivery of DCS. Gamma band modulations in response to 4 language tasks at each electrode were visualized in real-time. Next, DCS was conducted for each neighboring electrode pair during language tasks. Results All language tasks resulted in strongest heat map activation at an electrode pair in the anterior to mid superior temporal gyrus. Consistent speech arrest during DCS was observed for Object and Action naming tasks at these same electrodes, indicating good correspondence with ECoG heat map recordings. This region corresponded well with posterior language representation via preoperative functional MRI. Conclusions Intraoperative real-time visualization of language task-based ECoG gamma band modulation is feasible and may help identify targets for DCS. If validated, this may improve the efficiency and accuracy of intraoperative language mapping.","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135203167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forthcoming Meetings 即将到来的会议
Q2 CLINICAL NEUROLOGY Pub Date : 2023-09-15 DOI: 10.1093/nop/npad052
Jennie W Taylor
Journal Article Forthcoming Meetings Get access Jennie W Taylor Jennie W Taylor Search for other works by this author on: Oxford Academic Google Scholar Neuro-Oncology Practice, Volume 10, Issue 5, October 2023, Page 495, https://doi.org/10.1093/nop/npad052 Published: 15 September 2023 Article history Corrected and typeset: 15 September 2023 Published: 15 September 2023
期刊文章即将召开的会议获取访问Jennie W Taylor Jennie W Taylor搜索作者的其他作品:牛津学术谷歌学者神经肿瘤学实践,第10卷,第5期,2023年10月,第495页,https://doi.org/10.1093/nop/npad052出版:2023年9月15日文章历史更正和排版:2023年9月15日出版:2023年9月15日
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引用次数: 0
Health-related Quality of Life of Pediatric Brain Tumor Survivors after Treatment in Jordan 约旦儿童脑肿瘤幸存者治疗后的健康相关生活质量
Q2 CLINICAL NEUROLOGY Pub Date : 2023-08-31 DOI: 10.1093/nop/npad054
Han Choi, Amr S Soliman, Randa Al Mousa, Jennifer Yeh, Jamal Khader, Iyad Sultan, Ahmad K H Ibrahimi
Abstract Background The number of cancer survivors and survivorship are increasing. Health-related quality of life (HRQOL) has not been widely studied in low-and-middle-income countries (LMICs). The aim of this study is to explore HRQOL of childhood brain tumor survivors and its determinants in Jordan. Methods Health-related quality of life information was collected from 80 patients treated at the King Hussein Cancer Center and their parents using the Pediatric Quality of Life Inventory (PedsQL) Generic Core Scales questionnaire in Arabic. Multivariable linear OLS regression models were used to analyze correlates of HRQOL and compare differences between child- and parent-reported responses. Results Health-related quality of life scores reported by survivors and by parents were positively correlated on all subscales and total PedsQL scores (r = 0.59, P = .001). Survivors reported better HRQOL in cognitive subscale (β = 0.56, P = .03) and worse HRQOL in work subscale (β = 0.43, P = .04), but no significant differences in the physical, emotional, and social subscales and total PedsQL scores. Significant predictors of HRQOL reported by parents and by children were different. Supratentorial tumor location was associated with a 10.97-unit lower physical HRQOL score, and recurrence of tumors predicted a 17.5-unit lower total HRQOL score, indicating worse quality of life. Male gender (β = 14.9, P = .002) and diagnosis of hypopituitarism (β = 16.1, P = .03) were associated with better HRQOL. Furthermore, patients that only had radiotherapy treatment had better emotional HRQOL (β = 32.9, P = .006) compared to patients that had combined radiotherapy and chemotherapy. Conclusion This study provides evidence on determinants of HRQOL of pediatric brain tumor patients in Jordan. Future studies need to capitalize on the findings of this study to institute a system for regular assessment of quality of life of pediatric cancer patients in Jordan and other countries with similar health care systems and sociocultural backgrounds.
摘要背景癌症幸存者的数量和生存率都在不断增加。与健康相关的生活质量(HRQOL)尚未在低收入和中等收入国家(LMICs)得到广泛研究。本研究的目的是探讨约旦儿童脑肿瘤幸存者的HRQOL及其决定因素。方法采用阿拉伯语儿科生活质量量表(PedsQL)通用核心量表,收集侯赛因国王癌症中心治疗的80例患者及其父母的健康相关生活质量信息。使用多变量线性OLS回归模型分析HRQOL的相关因素,并比较儿童和父母报告的反应之间的差异。结果幸存者和父母报告的健康相关生活质量评分在所有子量表和PedsQL总分上均呈正相关(r = 0.59, P = 0.001)。幸存者在认知亚量表中HRQOL较好(β = 0.56, P = 0.03),在工作亚量表中HRQOL较差(β = 0.43, P = 0.04),但在身体、情感和社会亚量表以及PedsQL总分上无显著差异。父母和孩子报告的HRQOL的显著预测因子存在差异。幕上肿瘤位置与物理HRQOL评分降低10.97个单位相关,肿瘤复发预测总HRQOL评分降低17.5个单位,表明生活质量较差。男性(β = 14.9, P = 0.002)和垂体功能减退(β = 16.1, P = 0.03)与较好的HRQOL相关。此外,单纯放疗患者的情绪HRQOL优于放化疗患者(β = 32.9, P = 0.006)。结论本研究为约旦儿童脑肿瘤患者HRQOL的影响因素提供了证据。未来的研究需要利用这项研究的结果,建立一个定期评估约旦和其他具有类似卫生保健系统和社会文化背景的国家儿童癌症患者生活质量的系统。
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引用次数: 0
Letter regarding "Acceptability and feasibility of neurocognitive assessments with adults with primary brain cancer and brain metastasis: A systematic review". 关于“成人原发性脑癌和脑转移的神经认知评估的可接受性和可行性:一项系统综述”的信。
IF 2.4 Q2 CLINICAL NEUROLOGY Pub Date : 2023-08-30 eCollection Date: 2023-10-01 DOI: 10.1093/nop/npad043
M Gorter, J G Röttgering, V Belgers, P C De Witt Hamer, L Douw, M Klein
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引用次数: 0
Response to letter regarding “Assessing the association between preoperative neurocognitive status and IDH1 mutation status in high-grade gliomas: A deeper look into potential confounding variables.” 对“评估高级别胶质瘤术前神经认知状态和IDH1突变状态之间的关系:对潜在混杂变量的深入研究”的回复。
Q2 CLINICAL NEUROLOGY Pub Date : 2023-08-25 DOI: 10.1093/nop/npad045
Evangelia Liouta, Aristotelis V Kalyvas, Spyridon Komaitis, Evangelos Drosos, Christos Koutsarnakis, Juan M García-Gómez, Javier Juan-Albarracín, Vasileios Katsaros, Theodosis Kalamatianos, Theodoros Argyrakos, George Stranjalis
Journal Article Response to letter regarding “Assessing the association between preoperative neurocognitive status and IDH1 mutation status in high-grade gliomas: A deeper look into potential confounding variables.” Get access Evangelia Liouta, Evangelia Liouta Department of Neurosurgery, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, GreeceAthens Microneurosurgery LaboratoryHellenic Center for Neurosurgical Research “Prof. Petros Kokkalis”, Athens, Greece Corresponding Author: Evangelia Liouta, PhD, Department of Neurosurgery, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece, Hellenic Center for Neurosurgical Research “Prof. Petros Kokkalis,” Athens, Greece (evangelialiouta286@hotmail.com). https://orcid.org/0000-0003-2948-9631 Search for other works by this author on: Oxford Academic Google Scholar Aristotelis V Kalyvas, Aristotelis V Kalyvas Department of Neurosurgery, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, GreeceDivision of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada https://orcid.org/0000-0002-0222-488X Search for other works by this author on: Oxford Academic Google Scholar Spyridon Komaitis, Spyridon Komaitis Department of Neurosurgery, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, GreeceAthens Microneurosurgery Laboratory https://orcid.org/0000-0002-7250-414X Search for other works by this author on: Oxford Academic Google Scholar Evangelos Drosos, Evangelos Drosos Department of Neurosurgery, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, GreeceAthens Microneurosurgery Laboratory https://orcid.org/0000-0002-0456-7317 Search for other works by this author on: Oxford Academic Google Scholar Christos Koutsarnakis, Christos Koutsarnakis Department of Neurosurgery, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, GreeceAthens Microneurosurgery Laboratory https://orcid.org/0000-0002-1363-5385 Search for other works by this author on: Oxford Academic Google Scholar Juan M García-Gómez, Juan M García-Gómez Grupo de Informática Biomédica (IBIME), Instituto de Aplicaciones de las Tecnologías de la Información y de las Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València, Valencia, Spain Search for other works by this author on: Oxford Academic Google Scholar Javier Juan-Albarracín, Javier Juan-Albarracín Grupo de Informática Biomédica (IBIME), Instituto de Aplicaciones de las Tecnologías de la Información y de las Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València, Valencia, Spain Search for other works by this author on: Oxford Academic Google Scholar Vasileios Katsaros, Vasileios Katsaros Department of Radiology, General Anti-Cancer and Oncological Hospital of Athens “St. Savvas,” Athens, Greece https://orcid.org/0000-0003-3087-1475 Search for ot
期刊文章对“评估高级别胶质瘤术前神经认知状态和IDH1突变状态之间的关系:对潜在混杂变量的深入研究”信函的回应。访问Evangelia Liouta, Evangelia Liouta神经外科,雅典国立和卡波distrian大学,Evangelismos医院,希腊雅典雅典微神经外科实验室,希腊神经外科研究中心“Prof. Petros Kokkalis”,希腊雅典Evangelia Liouta,博士,神经外科,雅典国立和Kapodistrian大学,Evangelismos医院,希腊雅典,希腊神经外科研究中心Petros Kokkalis教授,希腊雅典(evangelialiouta286@hotmail.com)。https://orcid.org/0000-0003-2948-9631搜索作者的其他作品:牛津学术谷歌学者Aristotelis V Kalyvas, Aristotelis V Kalyvas神经外科,雅典国立和卡波迪斯大学,希腊雅典Evangelismos医院神经外科,多伦多西部医院,大学健康网络,多伦多大学,多伦多,on,加拿大https://orcid.org/0000-0002-0222-488X搜索作者的其他作品:牛津学术谷歌学者Spyridon Komaitis, Spyridon Komaitis神经外科,雅典国立和Kapodistrian大学,Evangelismos医院,雅典微神经外科实验室https://orcid.org/0000-0002-7250-414X搜索作者的其他作品:牛津学术谷歌学者Evangelos Drosos, Evangelos Drosos神经外科,雅典国立和卡波迪兰大学,Evangelismos医院,雅典,希腊雅典微神经外科实验室https://orcid.org/0000-0002-0456-7317搜索作者的其他作品:牛津学术谷歌学者Christos Koutsarnakis, Christos Koutsarnakis神经外科,雅典国立和卡波迪斯特大学,Evangelismos医院,希腊雅典微神经外科实验室https://orcid.org/0000-0002-1363-5385牛津大学学术谷歌学者Juan M García-Gómez, Juan M García-Gómez西班牙巴伦西亚瓦伦西亚政治大学(Universitat politicnica de val ncia), las应用研究所Tecnologías de la Información y de las communicaciones Avanzadas (ITACA), Informática biomdica (IBIME)牛津大学学术谷歌学者Javier Juan-Albarracín, Javier Juan-Albarracín西班牙巴伦西亚瓦伦西亚政治大学应用研究所Tecnologías de la Información y de las communicaciones Avanzadas (ITACA) Informática biomacimica (IBIME)牛津学术谷歌学者Vasileios Katsaros, Vasileios Katsaros放射科,雅典“圣萨瓦斯”抗癌和肿瘤医院,希腊雅典https://orcid.org/0000-0003-3087-1475搜索作者的其他作品:牛津学术谷歌学者Theodosis Kalamatianos, Theodosis Kalamatianos神经外科,雅典国立和卡波迪斯特兰大学,Evangelismos医院,雅典,希腊雅典希腊神经外科研究中心“Prof. Petros Kokkalis”,希腊雅典https://orcid.org/0000-0003-4634-2965牛津学术谷歌学者Theodoros Argyrakos, Theodoros Argyrakos病理学部,福音医院,雅典,希腊搜索作者的其他作品:牛津学术谷歌学者…显示更多乔治·斯特兰加里斯乔治·斯特兰加里斯神经外科,雅典国立和卡波迪兰大学,Evangelismos医院,希腊雅典雅典微神经外科实验室,希腊神经外科研究中心“教授Petros Kokkalis”,希腊雅典https://orcid.org/0000-0002-9556-0101搜索作者的其他作品:牛津学术谷歌学者神经肿瘤学实践,npad045, https://doi.org/10.1093/nop/npad045出版:2023年8月25日
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Neuro-oncology practice
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