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[Breakeven Analysis for Imaging Devices: Basic Introduction with Presentation of a User-Friendly Tool for in-clinic Calculation Using PET/CT as an Example]. [成像设备的盈亏平衡分析:基本介绍,并以PET/CT为例介绍一种用户友好的临床计算工具]。
IF 1.5 4区 医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-06-01 DOI: 10.1055/a-2036-7694
Claus Zippel, Christina Antke, Yuriko Mori, Antje Sombetzki, Gerald Antoch, Frederik L Giesel

Background: Imaging devices such as PET/CT are becoming increasingly important in view of the growing range of innovative nuclear medicine diagnostic procedures. Since the procurement and commissioning as well as the ongoing operation of imaging devices leads to comparatively high costs, it is of great interest for clinics and practices to know the number of scans from which the (planned) device operation leads to a profit. In the following, we will introduce the breakeven point analysis and present a calculation tool that users in nuclear medicine clinics and practices can use in everyday operations using PET/CT as an example.

Methods: In the breakeven point analysis, the intersection point is determined from which the organisation- or device-specific revenues exceed the total costs incurred for personnel, material resources, etc. For this purpose, the fixed and variable (planned) cost components for the procurement and operation of the device must be prepared on the cost side and the respective device-related (planned) revenue structure on the revenue side.

Results: The authors present the break-even analysis method with the data processing required for this using the example of the planned procurement or ongoing operation of a PET/CT. In addition, a calculation tool was developed, that interested users can use to prepare a device-specific break-even analysis. For this purpose, various cost and revenue data are discussed, which have to be compiled and processed within the clinic and entered into prepared spreadsheets.

Conclusion: The breakeven point analysis can be used to determine the profit/loss (point) for the (planned) operation of imaging devices such as PET/CT. Users from imaging clinics/practices and administration can adapt the calculation tool presented to their specific facility and thus use it as a basic document for both the planned procurement and the ongoing operational control of imaging devices in everyday clinical practice.

背景:鉴于越来越多的创新核医学诊断程序,PET/CT等成像设备正变得越来越重要。由于成像设备的采购和调试以及持续运行导致相对较高的成本,因此诊所和实践非常感兴趣的是了解(计划)设备操作带来利润的扫描次数。下面,我们将介绍盈亏平衡点分析,并以PET/CT为例,为核医学诊所和实践的用户提供一个可以在日常操作中使用的计算工具。方法:在盈亏平衡点分析中,确定组织或设备特定收入超过人员,物质资源等总成本的交叉点。为此,必须在成本方面准备设备采购和运行的固定和可变(计划)成本组成部分,并在收入方面准备与设备相关的各自(计划)收入结构。结果:作者以计划采购或正在进行的PET/CT操作为例,提出了盈亏平衡分析方法和所需的数据处理。此外,还开发了一个计算工具,感兴趣的用户可以使用它来准备特定于设备的盈亏平衡分析。为此,讨论了各种成本和收入数据,这些数据必须在诊所内进行编译和处理,并输入准备好的电子表格。结论:盈亏平衡点分析可用于确定PET/CT等成像设备(计划)操作的盈亏(点)。成像诊所/实践和管理部门的用户可以根据他们的具体设施调整所提供的计算工具,从而将其作为日常临床实践中计划采购和持续操作控制成像设备的基本文件。
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引用次数: 0
[68Ga]Ga-PSMA-11 uptake in planepitheliale lung cancer: a pitfall in prostate cancer imaging. [68Ga]平上皮性肺癌中Ga-PSMA-11的摄取:前列腺癌影像学的一个缺陷。
IF 1.5 4区 医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-06-01 DOI: 10.1055/a-2000-5589
Paulina Cegla, Marta Wojewodzka-Mirocha, Wioletta Chalewska, Marek Dedecjus
Prostate cancer (PCa) is the second most frequent cancer diagnosis made in men and the fifth leading cause of death worldwide [1]. Prostate-specific membrane antigen labeled with gallium 68 ([68Ga]GaPSMA-11) is a promising radiotracer frequently used in diagnostics of the patients with biochemical recurrence of PCa. PSMA’s expression in non-small cell lung cancer (NSCLC) ranks around 16 %, while tumor neovasculature expression is seen in 59% of tumor samples and is dependent on NSCLC histopathological type. The highest (71%) is seen in large cell carcinoma (LCC) and in squamous cell carcinoma (SCC) – 64%, while the lowest (45%) is noted in adenocarcinoma (AC) [2, 3]. A 77-year-old man with prostate adenocarcinoma, Gleason 7 (3 + 4), TNM T2bNxM0, during hormonotherapy and urothelial carcinoma (T1bNxM0) during BCG therapy, was referred to [68Ga]GaPSMA-11 PET/CT study due to biochemical recurrence (total prostate specific antigen (t-PSA) 0.449 ng/ml). A cystoscopy performed one week before PET/CT examination was clear. The [68Ga]Ga-PSMA-11 showed an increased focal PSMA ligand uptake at the right side of the small pelvis (SUVmaxlbm up to 9.2, ▶ Fig. 1A), lump in segment 6 of the right lung (SUVmaxlbm up to 2.4, ▶ Fig. 1B) and area of parenchyma consolidation in segment 10 of the right lung (SUVmaxlbm up to 2.6, ▶ Fig. 1C). Moreover, [68Ga]Ga-PSMA-11 also revealed areas of pathological osteosclerotic remodeling in both hip bones and in both pubic bones without increased PSMA uptake. Patient underwent a resection of a lump (segment 6) in the right lung which revealed planoepitheliale lung cancer G3, pT1R0L1V1. Three months after resection, patient was referred to [18F]FDG PET/CT study which revealed (shown earlier in [68Ga]Ga-PSMA-11) tumor in segment 10 of the right lung (50 × 38 mm, SUVmaxlbm up to 12.3, ▶ Fig. 1D), branch of the diaphragm lymph node (18 × 20mm, SUVmaxlbm up to 5.8) and metastatic lesion in III right rib. Other changes in bones did not show any pathological uptake. Patient because of the comorbidities, age and extension of the disease was treated with palliative radiotherapy of the lung. A 69-year-old man t-PSA level 2.47 [ng/ mL], after prostatectomy followed by radiotherapy of regional lymph nodes and complementary hormonotherapy in 2007, currently under palliative hormonotherapy underwent [68Ga]Ga-PSMA-11 PET/CT study because of biochemical recurrence. The scan revealed a focal PSMA ligand uptake in the small pelvis (SUVmaxlbm up to 3.6), in enlarged right hilar lymph node SUVmaxlbm up to 2.7 (▶ Fig. 2A) and a soft-tissue lesion in left lung lower lobe (▶ Fig. 2B) with SUVmaxlbm up to 2.0. Patient a few months after [68Ga]Ga-PSMA11 PET/CT underwent a computed tomography (CT) examination of a thorax which showed right upper lobe mass extending round the main bronchus and involving hilar lymph nodes (▶ Fig. 2C). The soft-tissue lesion in the left lung lower lobe was less consolidated and more irregular in shape with a small cavity,
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引用次数: 0
Correction: Synthesis of Prospective Multiple Time Points F-18 FDG PET Images from a Single Scan Using a Supervised Generative Adversarial Network. 更正:使用监督生成对抗网络从单次扫描合成前瞻性多时间点F-18 FDG PET图像。
IF 1.5 4区 医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-04-01 DOI: 10.1055/a-2095-2016
Merhnoosh Karimipourfard, Sedigheh Sina, Fereshteh Khodadai Shoshtari, Mehrosadat Alavi
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引用次数: 1
[Is there an unmet need to establish a young talent section "Young DGN" within the German Society of Nuclear Medicine (DGN)? - Results of a 2021/2022 web-based survey among German Nuclear Medicine professionals]. [是否需要在德国核医学学会(DGN)内建立一个年轻人才部门“年轻DGN”?-德国核医学专业人员2021/2022年网络调查结果]。
IF 1.5 4区 医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-04-01 DOI: 10.1055/a-1984-8116
Yasemin Aylin Sahin, Friederike Eilsberger, Eric Einspänner, Johannes Kunz, Sarah Spreckelmeyer, Markus Luster, Winfried Brenner, Benjamin Kläsner, Adrien Holzgreve

Aim: In various medical societies, dedicated young talent sections provide an important basis for promoting young members. However, the German Society of Nuclear Medicine (DGN) had not yet implemented such a section. Therefore, the aim of this work was to assess the opinion of nuclear medicine professionals in Germany on establishing a young talent section within the DGN ("Young DGN").

Methods: An initiative group of young DGN members developed a survey questionnaire comprising 18 questions. The questionnaire was initially sent as a PDF to the members of the DGN University Committee (Hochschulausschuss) by e-mail on 10/12/2021. As an online survey, the questionnaire was then emailed at four additional time points between 12/23/2021 and 3/18/2022 via the DGN eBrief and on 2/23/2022 to the members of the mailing list of the Berufsverband Deutscher Nuklearmediziner (BDN).

Results: The survey closed on 3/31/2022 with 111 responses (n=104 online surveys, n=7 PDFs). The median age of participants was 32.5 years (range, 20-80). 86% of participants indicated that they were interested in a Young DGN section, of which 67% were willing to participate. 79% indicated that nuclear medicine was an exciting field for them. 96% expressed interest in additional education offers and 60% in the establishment of a mentoring program. 75% believed that Young DGN would improve the visibility of the specialty.

Conclusion: The survey results indicate strong support for the establishment of a young talent section within the DGN among nuclear medicine professionals in Germany. A large proportion of those who participated in the survey would envision active involvement. There was a particular consensus on the desire to expand the range of education and training activities.

目的:在各个医学学会中,专门的青年人才部门为青年会员的提升提供了重要的基础。然而,德国核医学学会(DGN)尚未执行这一节。因此,这项工作的目的是评估德国核医学专业人员对在DGN内建立年轻人才部门(“年轻DGN”)的意见。方法:一个由年轻DGN成员组成的倡议小组开发了一份包括18个问题的调查问卷。问卷最初于2021年12月10日以PDF格式通过电子邮件发送给DGN大学委员会(Hochschulausschuss)的成员。作为一项在线调查,问卷随后在2021年12月23日至2022年3月18日之间的四个额外时间点通过DGN eBrief和2022年2月23日通过电子邮件发送给Berufsverband Deutscher Nuklearmediziner (BDN)邮件列表的成员。结果:该调查于2022年3月31日结束,共有111份回复(n=104份在线调查,n=7份pdf)。参与者的中位年龄为32.5岁(范围20-80岁)。86%的参与者表示他们对年轻的DGN部分感兴趣,其中67%的人愿意参加。79%的人表示核医学对他们来说是一个令人兴奋的领域。96%的人表示有兴趣获得额外的教育机会,60%的人希望建立一个指导计划。75%的人认为年轻的DGN会提高该专业的知名度。结论:调查结果表明,德国核医学专业人员强烈支持在DGN内建立青年人才部门。很大一部分参与调查的人会设想积极参与。对于希望扩大教育和培训活动的范围,大家达成了特别的协商一致意见。
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引用次数: 1
Synthesis of Prospective Multiple Time Points F-18 FDG PET Images from a Single Scan Using a Supervised Generative Adversarial Network. 使用监督生成对抗网络从单次扫描合成前瞻性多时间点F-18 FDG PET图像。
IF 1.2 4区 医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-04-01 Epub Date: 2023-03-06 DOI: 10.1055/a-2026-0784
Merhnoosh Karimipourfard, Sedigheh Sina, Fereshteh Khodadai Shoshtari, Mehrosadat Alavi

The cumulative activity map estimation are essential tools for patient specific dosimetry with high accuracy, which is estimated using biokinetic models instead of patient dynamic data or the number of static PET scans, owing to economical and time-consuming points of view. In the era of deep learning applications in medicine, the pix-to-pix (p2 p) GAN neural networks play a significant role in image translation between imaging modalities. In this pilot study, we extended the p2 p GAN networks to generate PET images of patients at different times according to a 60 min scan time after the injection of F-18 FDG. In this regard, the study was conducted in two sections: phantom and patient studies. In the phantom study section, the SSIM, PSNR, and MSE metric results of the generated images varied from 0.98-0.99, 31-34 and 1-2 respectively and the fine-tuned Resnet-50 network classified the different timing images with high performance. In the patient study, these values varied from 0.88-0.93, 36-41 and 1.7-2.2, respectively and the classification network classified the generated images in the true group with high accuracy. The results of phantom studies showed high values of evaluation metrics owing to ideal image quality conditions. However, in the patient study, promising results were achieved which showed that the image quality and training data number affected the network performance. This study aims to assess the feasibility of p2 p GAN network application for different timing image generation.

累积活动图估计是高精度患者特定剂量学的重要工具,由于经济和耗时的观点,它使用生物动力学模型而不是患者动态数据或静态PET扫描次数来估计。在医学深度学习应用的时代,像素到像素(p2 p) GAN神经网络在成像模式之间的图像转换中发挥着重要作用。在这项初步研究中,我们扩展了p2 p GAN网络,根据注射F-18 FDG后60分钟的扫描时间,生成患者在不同时间的PET图像。在这方面,研究分为两个部分进行:幻影和患者研究。在幻影研究部分,生成图像的SSIM、PSNR和MSE度量结果分别为0.98-0.99、31-34和1-2,微调后的Resnet-50网络对不同时序图像进行了高性能分类。在患者研究中,这些值分别为0.88-0.93、36-41和1.7-2.2,分类网络对真实组生成的图像进行了较高的分类准确率。幻影研究结果表明,由于理想的图像质量条件,评估指标具有很高的价值。然而,在患者研究中,取得了令人鼓舞的结果,表明图像质量和训练数据数量会影响网络性能。本研究旨在评估p2 p GAN网络应用于不同时序图像生成的可行性。
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引用次数: 0
F18-FDG PET/CT in a patient with Antisynthetase Syndrome. 1例抗合成酶综合征患者的F18-FDG PET/CT。
IF 1.5 4区 医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-04-01 DOI: 10.1055/a-1996-0157
Tina Nazerani-Zemann, Susanne Stanzel, Christian Gstettner, Reingard Maria Aigner, Birgit Pernthaler

More prevalent in women than men, Antisynthetase Syndrome is a rare and poorly defined autoimmune disease associated with interstitial lung disease, polymyositis, and dermatomyositis. In addition to various diagnostic tools, imaging modalities are needed in certain situations. A 42-year-old woman with Anti-Jo-1-positive Antisynthetase Syndrome presented with thoracic muscular pain. She underwent whole-body Fluorodeoxyglucose positron emission tomography/computed tomography (F18-FDG PET/CT) to evaluate the total extent of the muscles affected. Depicting symptomatic symmetric myositis of the intercostal muscles, F18-FDG PET/CT additionally revealed unusually extensive fasciitis of the lower extremities.

抗合成酶综合征是一种罕见且定义不清的自身免疫性疾病,与间质性肺疾病、多发性肌炎和皮肌炎相关。除了各种诊断工具外,在某些情况下还需要成像模式。一名42岁女性,患有抗jo -1阳性抗合成酶综合征,表现为胸部肌肉疼痛。她接受了全身氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(F18-FDG PET/CT)来评估受影响肌肉的总范围。F18-FDG PET/CT还显示下肢异常广泛的筋膜炎,描述肋间肌对称性肌炎的症状。
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引用次数: 0
[Hand in hand - the future of SPECT and PET imaging]. [手拉手——SPECT和PET成像的未来]。
IF 1.2 4区 医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-04-01 Epub Date: 2023-03-30 DOI: 10.1055/a-1998-8402
Friederike Eilsberger, Constantin Lapa, Benjamin Kläsner, Michael Andreas Schäfers, Markus Luster
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引用次数: 0
Lutetium-177 PSMA radioligand therapy for metastatic castration resistant prostate cancer in Germany: population-based data with multicenter validation from 2016 to 2020 Lutetium-177 PSMA放射配体治疗德国转移性去势抵抗性前列腺癌:2016年至2020年基于人群的多中心验证数据
4区 医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-03-30 DOI: 10.1055/s-0043-1766222
L. Flegar, S. Thoduka, D. Librizzi, M. Luster, A. Zacharis, H. Heers, N. Eisenmenger, H. Ahmadzadehfar, M. Eiber, W. Weber, C. Groeben, J. Huber
Ziel/Aim To investigate the adoption and current trends of Lutetium-177 PSMA radioligand therapy (RLT) for metastatic castration-resistant prostate cancer (mCRPC) in Germany.
目的:研究德国转移性去势抵抗性前列腺癌(mCRPC)的Lutetium-177 PSMA放射配体治疗(RLT)的采用情况和当前趋势。
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引用次数: 0
Novel Ga-68-FAPI PET/CT offers oncologic staging without COVID-19 vaccine-related pitfalls 新型Ga-68-FAPI PET/CT提供无COVID-19疫苗相关陷阱的肿瘤分期
4区 医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-03-30 DOI: 10.1055/s-0043-1766277
T. Demmert, I. Maric, K. Pomykala, K. Lückerath, J. Siveke, B. Schaarschmidt, R. Hamacher, L. Kessler, N. Hirmas, K. Pabst, T. Bartel, K. Herrmann, W. Fendler
Ziel/Aim The global SARS-CoV-2 vaccination campaign brought attention to a recent pitfall in tumor staging by PET/CT. Several publications reported a non-specific F-18-FDG tracer uptake in axillary lymph nodes after COVID-19 vaccination. Ga-68-FAPI PET/CT is a new oncologic imaging tool that may overcome this limitation.
全球SARS-CoV-2疫苗接种运动引起了人们对PET/CT肿瘤分期的一个最新缺陷的关注。一些出版物报道了COVID-19疫苗接种后腋窝淋巴结的非特异性F-18-FDG示踪剂摄取。Ga-68-FAPI PET/CT是一种新的肿瘤成像工具,可以克服这一局限性。
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引用次数: 0
Selective α-Synuclein PET Radiotracer Development- Characterization 选择性α-突触核蛋白PET示踪剂的研制与表征
4区 医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-03-30 DOI: 10.1055/s-0043-1766158
B. Hooshyar Yousefi, B. C. Uzuegbunam, W. Paslawski, G. B. Kotipalli, M. Luster, D. Librizzi, W. Weber, P. Svenningsson, T. Arzberger
Ziel/Aim The deposition of α-synuclein fibrils (α-syn) is a major feature that unites a group of neurodegenerative diseases collectively known as the synucleinopathies. Presently, the in vivo detection of this biomarker is not possible due to lack of suitable radiotracers. Scientists from academics and industry are interested to develop radiotracers for the early diagnosis of α-synucleinopathies. Disarylbisthiazoles (DABTAs) based ligands have been showing high affinity towards α-syn and excellent selectivity over tau and Aβ aggregates. The aim of this work is characterization of the radiotracers within competition binding assays, autoradiography and pharmacokinetics (PK) study to confirm their high binding affinity and optimized pharmacokinetics and utilize them as a promising α-syn PET tracer.
α-突触核蛋白原纤维(α-syn)的沉积是联合一组神经退行性疾病(统称为突触核蛋白病)的主要特征。目前,由于缺乏合适的放射性示踪剂,这种生物标志物的体内检测是不可能的。学术界和工业界的科学家对开发用于α-突触核蛋白病早期诊断的放射性示踪剂很感兴趣。基于二芳基双噻唑(DABTAs)的配体对α-syn具有高亲和力,对tau和a - β聚集物具有良好的选择性。本研究的目的是在竞争结合分析、放射自显影和药代动力学(PK)研究中对放射性示踪剂进行表征,以证实其高结合亲和力和优化的药代动力学,并将其作为一种有前景的α-syn PET示踪剂。
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引用次数: 0
期刊
Nuklearmedizin-nuclear Medicine
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