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Correction: Synthesis of Prospective Multiple Time Points F-18 FDG PET Images from a Single Scan Using a Supervised Generative Adversarial Network. 更正:使用监督生成对抗网络从单次扫描合成前瞻性多时间点F-18 FDG PET图像。
IF 1.5 4区 医学 Q3 Medicine Pub Date : 2023-04-01 DOI: 10.1055/a-2095-2016
Merhnoosh Karimipourfard, Sedigheh Sina, Fereshteh Khodadai Shoshtari, Mehrosadat Alavi
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引用次数: 1
Synthesis of Prospective Multiple Time Points F-18 FDG PET Images from a Single Scan Using a Supervised Generative Adversarial Network. 使用监督生成对抗网络从单次扫描合成前瞻性多时间点F-18 FDG PET图像。
IF 1.5 4区 医学 Q3 Medicine Pub Date : 2023-04-01 DOI: 10.1055/a-2026-0784
Merhnoosh Karimipourfard, Sedigheh Sina, Fereshteh Khodadai Shoshtari, Mehrsadat Alavi

The cumulative activity map estimation are essential tools for patient specific dosimetry with high accuracy, which is estimated using biokinetic models instead of patient dynamic data or the number of static PET scans, owing to economical and time-consuming points of view. In the era of deep learning applications in medicine, the pix-to-pix (p2 p) GAN neural networks play a significant role in image translation between imaging modalities. In this pilot study, we extended the p2 p GAN networks to generate PET images of patients at different times according to a 60 min scan time after the injection of F-18 FDG. In this regard, the study was conducted in two sections: phantom and patient studies. In the phantom study section, the SSIM, PSNR, and MSE metric results of the generated images varied from 0.98-0.99, 31-34 and 1-2 respectively and the fine-tuned Resnet-50 network classified the different timing images with high performance. In the patient study, these values varied from 0.88-0.93, 36-41 and 1.7-2.2, respectively and the classification network classified the generated images in the true group with high accuracy. The results of phantom studies showed high values of evaluation metrics owing to ideal image quality conditions. However, in the patient study, promising results were achieved which showed that the image quality and training data number affected the network performance. This study aims to assess the feasibility of p2 p GAN network application for different timing image generation.

累积活动图估计是高精度患者特定剂量学的重要工具,由于经济和耗时的观点,它使用生物动力学模型而不是患者动态数据或静态PET扫描次数来估计。在医学深度学习应用的时代,像素到像素(p2 p) GAN神经网络在成像模式之间的图像转换中发挥着重要作用。在这项初步研究中,我们扩展了p2 p GAN网络,根据注射F-18 FDG后60分钟的扫描时间,生成患者在不同时间的PET图像。在这方面,研究分为两个部分进行:幻影和患者研究。在幻影研究部分,生成图像的SSIM、PSNR和MSE度量结果分别为0.98-0.99、31-34和1-2,微调后的Resnet-50网络对不同时序图像进行了高性能分类。在患者研究中,这些值分别为0.88-0.93、36-41和1.7-2.2,分类网络对真实组生成的图像进行了较高的分类准确率。幻影研究结果表明,由于理想的图像质量条件,评估指标具有很高的价值。然而,在患者研究中,取得了令人鼓舞的结果,表明图像质量和训练数据数量会影响网络性能。本研究旨在评估p2 p GAN网络应用于不同时序图像生成的可行性。
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引用次数: 0
[Is there an unmet need to establish a young talent section "Young DGN" within the German Society of Nuclear Medicine (DGN)? - Results of a 2021/2022 web-based survey among German Nuclear Medicine professionals]. [是否需要在德国核医学学会(DGN)内建立一个年轻人才部门“年轻DGN”?-德国核医学专业人员2021/2022年网络调查结果]。
IF 1.5 4区 医学 Q3 Medicine Pub Date : 2023-04-01 DOI: 10.1055/a-1984-8116
Yasemin Aylin Sahin, Friederike Eilsberger, Eric Einspänner, Johannes Kunz, Sarah Spreckelmeyer, Markus Luster, Winfried Brenner, Benjamin Kläsner, Adrien Holzgreve

Aim: In various medical societies, dedicated young talent sections provide an important basis for promoting young members. However, the German Society of Nuclear Medicine (DGN) had not yet implemented such a section. Therefore, the aim of this work was to assess the opinion of nuclear medicine professionals in Germany on establishing a young talent section within the DGN ("Young DGN").

Methods: An initiative group of young DGN members developed a survey questionnaire comprising 18 questions. The questionnaire was initially sent as a PDF to the members of the DGN University Committee (Hochschulausschuss) by e-mail on 10/12/2021. As an online survey, the questionnaire was then emailed at four additional time points between 12/23/2021 and 3/18/2022 via the DGN eBrief and on 2/23/2022 to the members of the mailing list of the Berufsverband Deutscher Nuklearmediziner (BDN).

Results: The survey closed on 3/31/2022 with 111 responses (n=104 online surveys, n=7 PDFs). The median age of participants was 32.5 years (range, 20-80). 86% of participants indicated that they were interested in a Young DGN section, of which 67% were willing to participate. 79% indicated that nuclear medicine was an exciting field for them. 96% expressed interest in additional education offers and 60% in the establishment of a mentoring program. 75% believed that Young DGN would improve the visibility of the specialty.

Conclusion: The survey results indicate strong support for the establishment of a young talent section within the DGN among nuclear medicine professionals in Germany. A large proportion of those who participated in the survey would envision active involvement. There was a particular consensus on the desire to expand the range of education and training activities.

目的:在各个医学学会中,专门的青年人才部门为青年会员的提升提供了重要的基础。然而,德国核医学学会(DGN)尚未执行这一节。因此,这项工作的目的是评估德国核医学专业人员对在DGN内建立年轻人才部门(“年轻DGN”)的意见。方法:一个由年轻DGN成员组成的倡议小组开发了一份包括18个问题的调查问卷。问卷最初于2021年12月10日以PDF格式通过电子邮件发送给DGN大学委员会(Hochschulausschuss)的成员。作为一项在线调查,问卷随后在2021年12月23日至2022年3月18日之间的四个额外时间点通过DGN eBrief和2022年2月23日通过电子邮件发送给Berufsverband Deutscher Nuklearmediziner (BDN)邮件列表的成员。结果:该调查于2022年3月31日结束,共有111份回复(n=104份在线调查,n=7份pdf)。参与者的中位年龄为32.5岁(范围20-80岁)。86%的参与者表示他们对年轻的DGN部分感兴趣,其中67%的人愿意参加。79%的人表示核医学对他们来说是一个令人兴奋的领域。96%的人表示有兴趣获得额外的教育机会,60%的人希望建立一个指导计划。75%的人认为年轻的DGN会提高该专业的知名度。结论:调查结果表明,德国核医学专业人员强烈支持在DGN内建立青年人才部门。很大一部分参与调查的人会设想积极参与。对于希望扩大教育和培训活动的范围,大家达成了特别的协商一致意见。
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引用次数: 1
F18-FDG PET/CT in a patient with Antisynthetase Syndrome. 1例抗合成酶综合征患者的F18-FDG PET/CT。
IF 1.5 4区 医学 Q3 Medicine Pub Date : 2023-04-01 DOI: 10.1055/a-1996-0157
Tina Nazerani-Zemann, Susanne Stanzel, Christian Gstettner, Reingard Maria Aigner, Birgit Pernthaler

More prevalent in women than men, Antisynthetase Syndrome is a rare and poorly defined autoimmune disease associated with interstitial lung disease, polymyositis, and dermatomyositis. In addition to various diagnostic tools, imaging modalities are needed in certain situations. A 42-year-old woman with Anti-Jo-1-positive Antisynthetase Syndrome presented with thoracic muscular pain. She underwent whole-body Fluorodeoxyglucose positron emission tomography/computed tomography (F18-FDG PET/CT) to evaluate the total extent of the muscles affected. Depicting symptomatic symmetric myositis of the intercostal muscles, F18-FDG PET/CT additionally revealed unusually extensive fasciitis of the lower extremities.

抗合成酶综合征是一种罕见且定义不清的自身免疫性疾病,与间质性肺疾病、多发性肌炎和皮肌炎相关。除了各种诊断工具外,在某些情况下还需要成像模式。一名42岁女性,患有抗jo -1阳性抗合成酶综合征,表现为胸部肌肉疼痛。她接受了全身氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(F18-FDG PET/CT)来评估受影响肌肉的总范围。F18-FDG PET/CT还显示下肢异常广泛的筋膜炎,描述肋间肌对称性肌炎的症状。
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引用次数: 0
[Hand in hand - the future of SPECT and PET imaging]. [手拉手——SPECT和PET成像的未来]。
IF 1.5 4区 医学 Q3 Medicine Pub Date : 2023-04-01 DOI: 10.1055/a-1998-8402
Friederike Eilsberger, Constantin Lapa, Benjamin Kläsner, Michael Andreas Schäfers, Markus Luster
Institute 1 Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany 2 Medical Faculty, Nuclear Medicine, University of Augsburg, Augsburg, Germany 3 Department of Nuclear Medicine, Klinikum Konstanz, Konstanz, Germany 4 Department of Nuclear Medicine, University Hospital Münster, Münster, Germany Bibliografie Nuklearmedizin 2023; 62: 52–53 DOI 10.1055/a-1998-8402 ISSN 0029-5566 © 2023. Thieme. All rights reserved. Georg Thieme Verlag KG, Rüdigerstraße 14, 70469 Stuttgart, Germany
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引用次数: 0
Lutetium-177 PSMA radioligand therapy for metastatic castration resistant prostate cancer in Germany: population-based data with multicenter validation from 2016 to 2020 Lutetium-177 PSMA放射配体治疗德国转移性去势抵抗性前列腺癌:2016年至2020年基于人群的多中心验证数据
4区 医学 Q3 Medicine Pub Date : 2023-03-30 DOI: 10.1055/s-0043-1766222
L. Flegar, S. Thoduka, D. Librizzi, M. Luster, A. Zacharis, H. Heers, N. Eisenmenger, H. Ahmadzadehfar, M. Eiber, W. Weber, C. Groeben, J. Huber
Ziel/Aim To investigate the adoption and current trends of Lutetium-177 PSMA radioligand therapy (RLT) for metastatic castration-resistant prostate cancer (mCRPC) in Germany.
目的:研究德国转移性去势抵抗性前列腺癌(mCRPC)的Lutetium-177 PSMA放射配体治疗(RLT)的采用情况和当前趋势。
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引用次数: 0
Novel Ga-68-FAPI PET/CT offers oncologic staging without COVID-19 vaccine-related pitfalls 新型Ga-68-FAPI PET/CT提供无COVID-19疫苗相关陷阱的肿瘤分期
4区 医学 Q3 Medicine Pub Date : 2023-03-30 DOI: 10.1055/s-0043-1766277
T. Demmert, I. Maric, K. Pomykala, K. Lückerath, J. Siveke, B. Schaarschmidt, R. Hamacher, L. Kessler, N. Hirmas, K. Pabst, T. Bartel, K. Herrmann, W. Fendler
Ziel/Aim The global SARS-CoV-2 vaccination campaign brought attention to a recent pitfall in tumor staging by PET/CT. Several publications reported a non-specific F-18-FDG tracer uptake in axillary lymph nodes after COVID-19 vaccination. Ga-68-FAPI PET/CT is a new oncologic imaging tool that may overcome this limitation.
全球SARS-CoV-2疫苗接种运动引起了人们对PET/CT肿瘤分期的一个最新缺陷的关注。一些出版物报道了COVID-19疫苗接种后腋窝淋巴结的非特异性F-18-FDG示踪剂摄取。Ga-68-FAPI PET/CT是一种新的肿瘤成像工具,可以克服这一局限性。
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引用次数: 0
Selective α-Synuclein PET Radiotracer Development- Characterization 选择性α-突触核蛋白PET示踪剂的研制与表征
4区 医学 Q3 Medicine Pub Date : 2023-03-30 DOI: 10.1055/s-0043-1766158
B. Hooshyar Yousefi, B. C. Uzuegbunam, W. Paslawski, G. B. Kotipalli, M. Luster, D. Librizzi, W. Weber, P. Svenningsson, T. Arzberger
Ziel/Aim The deposition of α-synuclein fibrils (α-syn) is a major feature that unites a group of neurodegenerative diseases collectively known as the synucleinopathies. Presently, the in vivo detection of this biomarker is not possible due to lack of suitable radiotracers. Scientists from academics and industry are interested to develop radiotracers for the early diagnosis of α-synucleinopathies. Disarylbisthiazoles (DABTAs) based ligands have been showing high affinity towards α-syn and excellent selectivity over tau and Aβ aggregates. The aim of this work is characterization of the radiotracers within competition binding assays, autoradiography and pharmacokinetics (PK) study to confirm their high binding affinity and optimized pharmacokinetics and utilize them as a promising α-syn PET tracer.
α-突触核蛋白原纤维(α-syn)的沉积是联合一组神经退行性疾病(统称为突触核蛋白病)的主要特征。目前,由于缺乏合适的放射性示踪剂,这种生物标志物的体内检测是不可能的。学术界和工业界的科学家对开发用于α-突触核蛋白病早期诊断的放射性示踪剂很感兴趣。基于二芳基双噻唑(DABTAs)的配体对α-syn具有高亲和力,对tau和a - β聚集物具有良好的选择性。本研究的目的是在竞争结合分析、放射自显影和药代动力学(PK)研究中对放射性示踪剂进行表征,以证实其高结合亲和力和优化的药代动力学,并将其作为一种有前景的α-syn PET示踪剂。
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引用次数: 0
DGN-Summer School 2023 2023年夏季学校
4区 医学 Q3 Medicine Pub Date : 2023-03-30 DOI: 10.1055/a-2040-9453
Wir freuen uns, nach einer 3-jährigen „Corona-Pause“ in diesem Jahr vom 24.-26. August 2023 die DGN-Summer School wieder an der Charité in Berlin zum Thema „Translational Research in Molecular Imaging and Radionuclide Therapy“ durchzuführen. Die wissenschaftliche Leitung liegt erneut bei Prof. Dr. Winfried Brenner, Berlin (D), Prof. Dr. Martin Gotthardt, Nijmegen (NL), und Prof. Dr. Felix M. Mottaghy, Aachen und Maastricht (NL).
今晚的"科罗那午休"结束了三年,一共24、26年2023年8月DGN-Summer elementary School再一次在Charité柏林主题”的文化研究在Molecular Imaging and Radionuclide治愈的“执行.科学委员会由柏林的温弗里德·班纳博士教授领导
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引用次数: 0
Intraindividual Comparison of Physiologic [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 Uptake in Ganglia in Patients with Prostate Cancer: a retrospective, monocentric analysis 前列腺癌患者神经节生理性[68Ga]Ga-PSMA-11和[18F]PSMA-1007摄取的个体内比较:回顾性单中心分析
4区 医学 Q3 Medicine Pub Date : 2023-03-30 DOI: 10.1055/s-0043-1766379
E. Novruzov, D. Schmitt, K. Mattes-György, M. Beu, J. M. Henke, C. Antke, J. Cardinale, G. Niegisch, L. Schimmöller, F. L. Giesel, E. Mamlins
Ziel/Aim Several studies indicate a relatively high rate of detection of benign findings, in particular ganglia, in PSMA PET imaging. To date, no studies have directly compared [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 ganglionic uptake intraindividually and analyzed the different detection rates and underlying molecular and physical mechanisms. With this monocentric retrospective study, we sought to evaluate the intraindividual physiological ganglion uptake of different PSMA ligands.
几项研究表明,在PSMA PET成像中,良性发现的检出率相对较高,尤其是神经节。到目前为止,还没有研究直接比较[68Ga]Ga-PSMA-11和[18F]PSMA-1007在个体内的神经节摄取,并分析不同的检出率及其潜在的分子和物理机制。通过这项单中心回顾性研究,我们试图评估个体内不同PSMA配体的生理神经节摄取。
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引用次数: 0
期刊
Nuklearmedizin-nuclear Medicine
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