Pub Date : 2023-09-11DOI: 10.1080/01658107.2023.2255665
Shikha Talwar Bassi, Aditya Verma
The purpose of this case report is to describe the optical coherence tomography (OCT) features of a peripapillary choroidal neovascular membrane (PPCNVM) in an eye with morning glory disc anomaly (MGDA). A PPCNVM appears as a hyper-reflective mass in the peripapillary area. It should be distinguished from peripapillary hyper-reflective ovoid mass-like structures, which are markers of axoplasmic flow stasis. This case report describes the distinguishing features between the two. The presence of intraretinal cystic spaces are indicative of an active PPCNVM. In conclusion, MGDA can be associated with PPCNVM and OCT can be used in its detection.
{"title":"Optical Coherence Tomography in a Morning Glory Disc Anomaly with a Peripapillary Choroidal Neovascular Membrane","authors":"Shikha Talwar Bassi, Aditya Verma","doi":"10.1080/01658107.2023.2255665","DOIUrl":"https://doi.org/10.1080/01658107.2023.2255665","url":null,"abstract":"The purpose of this case report is to describe the optical coherence tomography (OCT) features of a peripapillary choroidal neovascular membrane (PPCNVM) in an eye with morning glory disc anomaly (MGDA). A PPCNVM appears as a hyper-reflective mass in the peripapillary area. It should be distinguished from peripapillary hyper-reflective ovoid mass-like structures, which are markers of axoplasmic flow stasis. This case report describes the distinguishing features between the two. The presence of intraretinal cystic spaces are indicative of an active PPCNVM. In conclusion, MGDA can be associated with PPCNVM and OCT can be used in its detection.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135938897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.1080/01658107.2023.2251579
Nisreen Al-Balushi, Walid Bouthour, Ana Banc, Rasha Mosleh, Amit M. Saindane, Nancy J. Newman, Valérie Biousse
ABSTRACT Idiopathic intracranial hypertension (IIH) is a syndrome of isolated elevated intracranial pressure of unknown aetiology. The IIH spectrum has evolved over the past decade making the diagnosis and management more challenging. The neurological examination in IIH is typically normal except for papilloedema and possible cranial nerve 6 palsy. Recent publications have highlighted skull base thinning and remodelling in patients with chronic IIH. Resulting skull base defects can cause meningo-encephalocoeles, which are potential epileptogenic foci. We describe the clinical and radiological characteristics of five IIH patients with seizures and meningo-encephalocoeles as the presenting manifestations of IIH spectrum disorder.
{"title":"Seizures as the Initial Manifestation of Idiopathic Intracranial Hypertension Spectrum Disorder","authors":"Nisreen Al-Balushi, Walid Bouthour, Ana Banc, Rasha Mosleh, Amit M. Saindane, Nancy J. Newman, Valérie Biousse","doi":"10.1080/01658107.2023.2251579","DOIUrl":"https://doi.org/10.1080/01658107.2023.2251579","url":null,"abstract":"ABSTRACT Idiopathic intracranial hypertension (IIH) is a syndrome of isolated elevated intracranial pressure of unknown aetiology. The IIH spectrum has evolved over the past decade making the diagnosis and management more challenging. The neurological examination in IIH is typically normal except for papilloedema and possible cranial nerve 6 palsy. Recent publications have highlighted skull base thinning and remodelling in patients with chronic IIH. Resulting skull base defects can cause meningo-encephalocoeles, which are potential epileptogenic foci. We describe the clinical and radiological characteristics of five IIH patients with seizures and meningo-encephalocoeles as the presenting manifestations of IIH spectrum disorder.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135982247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-04DOI: 10.1080/01658107.2023.2216613
D. Bellows, John J. Chen, Hui-Chen Cheng, M. Vaphiades, Xiaojun Zhang
Neuro-Ophthalmic Literature Review David A. Bellows, John J. Chen, Hui-Chen Cheng, Michael S. Vaphiades, and Xiaojun Zhang The Medical Eye Center, Manchester, New Hampshire, USA; Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, Minnesota, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Ophthalmology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Departments of Ophthalmology, Neurology, and Neurosurgery, UAB Callahan Eye Hospital, Birmingham, AL, USA; Department of Neurology, Ohio State University Medical Center, Ohio, USA; Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China Characteristics of 110 Patients with Functional Visual Loss Sverdlichenko I, Brossard-Barbosa N, Micieli JA, Margolin E. Characteristics of 110 patients with functional visual loss. Am J Ophthalmol. 2023;250 171–176. Five to 15% of patients who present to a neuroophthalmology practice with a complaint of vision loss are diagnosed with functional visual loss (FVL). To complicate matters, as many as 53% of these patients are also diagnosed with a coexistent organic cause for their loss of vision. To identify the characteristics of patients with FVL, the authors reviewed the records of 110 patients who were diagnosed with FVL at university-affiliated neuroophthalmology clinics. The majority (73.8%) of patients were women with a mean age of 37 ± 15 years. The most common complaints were decreased vision (71.8%) followed by visual field defects (21.8%). In more than half of the patients the complaint was bilateral. Visual acuity improved in 95.9% of patients when tested with fogging and/or a bottom-up technique. The most common visual field defects were generalised depression (42.5%) followed by concentric constriction/tunnel vision (12.5%). Many patients had concurrent mental illness including depression (23.6%) and anxiety (22.7%) as well as other mental health conditions. A history of preceding trauma was present in 35% of patients. These patients incur considerable costs to the health care system. They averaged 4.6 health care visits with 3.7 of these being to medical specialists. They also averaged 2.2 neuroimaging studies in addition to other testing. The authors point out the fact that there can be considerable savings in terms of cost and patient anxiety if these patients are referred promptly for neuro-ophthalmological consultation. David Bellows GLP-1 Receptor Agonists: The Miracle Pill for IIH? Mitchell JL, Lyons HS, Walker JK, Yiangou A, Grech O, Alimajstorovic Z, et al. The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: A randomized clinical trial. Brain. 13 March 2023: awad003. doi: 10.1093/brain/awad003. Epub ahead of print. PMID: 36,907,221. Glucagon-like peptide-1 (GLP-1) receptor agonists are currently used as a treatment for diabetes and weight loss. The Birmingham, United Kingdom group previously sho
{"title":"Neuro-Ophthalmic Literature Review","authors":"D. Bellows, John J. Chen, Hui-Chen Cheng, M. Vaphiades, Xiaojun Zhang","doi":"10.1080/01658107.2023.2216613","DOIUrl":"https://doi.org/10.1080/01658107.2023.2216613","url":null,"abstract":"Neuro-Ophthalmic Literature Review David A. Bellows, John J. Chen, Hui-Chen Cheng, Michael S. Vaphiades, and Xiaojun Zhang The Medical Eye Center, Manchester, New Hampshire, USA; Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, Minnesota, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Ophthalmology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Departments of Ophthalmology, Neurology, and Neurosurgery, UAB Callahan Eye Hospital, Birmingham, AL, USA; Department of Neurology, Ohio State University Medical Center, Ohio, USA; Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China Characteristics of 110 Patients with Functional Visual Loss Sverdlichenko I, Brossard-Barbosa N, Micieli JA, Margolin E. Characteristics of 110 patients with functional visual loss. Am J Ophthalmol. 2023;250 171–176. Five to 15% of patients who present to a neuroophthalmology practice with a complaint of vision loss are diagnosed with functional visual loss (FVL). To complicate matters, as many as 53% of these patients are also diagnosed with a coexistent organic cause for their loss of vision. To identify the characteristics of patients with FVL, the authors reviewed the records of 110 patients who were diagnosed with FVL at university-affiliated neuroophthalmology clinics. The majority (73.8%) of patients were women with a mean age of 37 ± 15 years. The most common complaints were decreased vision (71.8%) followed by visual field defects (21.8%). In more than half of the patients the complaint was bilateral. Visual acuity improved in 95.9% of patients when tested with fogging and/or a bottom-up technique. The most common visual field defects were generalised depression (42.5%) followed by concentric constriction/tunnel vision (12.5%). Many patients had concurrent mental illness including depression (23.6%) and anxiety (22.7%) as well as other mental health conditions. A history of preceding trauma was present in 35% of patients. These patients incur considerable costs to the health care system. They averaged 4.6 health care visits with 3.7 of these being to medical specialists. They also averaged 2.2 neuroimaging studies in addition to other testing. The authors point out the fact that there can be considerable savings in terms of cost and patient anxiety if these patients are referred promptly for neuro-ophthalmological consultation. David Bellows GLP-1 Receptor Agonists: The Miracle Pill for IIH? Mitchell JL, Lyons HS, Walker JK, Yiangou A, Grech O, Alimajstorovic Z, et al. The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: A randomized clinical trial. Brain. 13 March 2023: awad003. doi: 10.1093/brain/awad003. Epub ahead of print. PMID: 36,907,221. Glucagon-like peptide-1 (GLP-1) receptor agonists are currently used as a treatment for diabetes and weight loss. The Birmingham, United Kingdom group previously sho","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"687 1","pages":"232 - 236"},"PeriodicalIF":0.8,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76857006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.1080/01658107.2023.2201136
D. Bellows, N. Chan, John J. Chen, Hui-Chen Cheng, P. Jindahra, P. Macintosh, Collin M. McClelland, M. Vaphiades, Xiaojun Zhang
Neuro-Ophthalmic Literature Review David A. Bellows, Noel C. Y. Chan, John J. Chen, Hui-Chen Cheng, Panitha Jindahra, Peter W. MacIntosh, Collin McClelland, Michael S. Vaphiades, and Xiaojun Zhang The Medical Eye Center, Manchester, New Hampshire, USA; Department of Ophthalmology & Visual Sciences, Prince of Wales Hospital & Alice Ho Miu Ling Nethersole Hospital, Hong Kong; Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong; Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, Minnesota, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Ophthalmology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Neurology, Mahidol University, Bangkok, Thailand; Department of Ophthalmology, Illinois Ear and Eye Infirmary, Chicago, Illinois, USA; Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota, USA; Departments of Ophthalmology, Neurology, and Neurosurgery, UAB Callahan Eye Hospital, Birmingham, Alexandria, USA; Department of Neurology, Ohio State University Medical Center, Columbus, Ohio, USA; Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, Hebei, China Peripapillary Hyperreflective Ovoid Mass-Like Structures: Multimodal Imaging – A Review Jeffery RCH, Chen FK. Peripapillary hyperreflective ovoid mass-like structures: Multimodal imaging-A review. Clin Exp Ophthalmol. 2023;51:67–80. Prior to the establishment of the Optic Disk Drusen Consortium the ovoid peripapillary structures detected on optical coherence tomography (OCT) were felt to be buried optic disk drusen. These structures have since been redefined as peripapillary hyperreflective ovoid mass-like structures (PHOMS) and identified as a manifestation of axoplasmic stasis. The authors discuss the characteristic findings of PHOMS on multimodal OCT and review the literature pertaining to the co-existence of PHOMS with diseases other than optic disk drusen. These include papilloedema, anterior ischaemic optic neuropathy, tilted disk syndrome, inflammatory demyelinating disorders as well as retinal and orbital diseases. David Bellows Anti-Hypertensive Medications – Before Bed or Not? Labowsky MT, Rizzo III JF. The controversy of chronotherapy: Emerging evidence regarding bedtime dosing of antihypertensive medications in non-arteritic anterior ischaemic optic neuropathy. Semin Ophthalmol. 2023;38:99–104. This is a review article highlighting the marked conflict between therapeutic recommendations published in the ophthalmology and cardiology literature, with the former arguing against taking anti-hypertensive medications at bedtime to reduce risk of sequential non-arteritic anterior ischaemic optic neuropathy (NAION) while the latter arguing in favour of bedtime dosing to reduce the risk of cardiovascular disease (CVD). The observation of “blinding upon awakening” in patients with NAION has prom
因此，对于神经眼科医生来说，在咨询因NAION而失去视力的患者时，注意到这一活跃而充满活力的争议是很重要的。Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan EP，等。髓鞘少突胶质细胞糖蛋白抗体相关疾病的诊断:国际MOGAD小组提出的标准。中华神经科杂志，2009;22:268-282。髓鞘少突胶质细胞糖蛋白(MOG)抗体相关疾病(MOGAD)的国际诊断标准最近发表在《柳叶刀神经病学》杂志上。MOGAD诊断标准为:(a)核心临床脱髓鞘事件:视神经炎;骨髓炎;急性播散性脑脊髓炎;大脑单灶性或多灶性缺陷;脑干或小脑缺陷;(b)基于细胞的MOG-IgG检测阳性(c)排除包括多发性硬化症在内的更好的诊断。与2015年发布的国际诊断标准不同，MOGAD的诊断取决于MOG-IgG检测阳性，并没有提出单独的血清阴性MOGAD分类。因此，MOGIgG检测的敏感性尚不清楚。然而，MOG-IgG检测的特异性已经得到了很好的研究，约为98%，在1:20和1:40的低滴度下特异性较低，具有阳性预测值。因此，与MOGAD诊断标准有一些细微差别，这在很大程度上取决于MOG-IgG检测不是100%特异性的知识。如果患者有较高的MOG-IgG滴度，存在核心临床脱髓鞘事件之一将足以满足诊断MOGAD的标准。然而，如果患者的MOG-IgG滴度较低，或者脑脊液中MOGIgG检测呈阳性，而血清中没有，则必须有临床或放射学支持结果提示MOGAD。例如，有助于诊断MOGAD视神经炎的检查结果包括双侧视神经炎、纵向视神经增强、神经周围视鞘增强和/或视盘水肿。还提供了支持MOGAD脊髓炎和脑发作的临床和放射学特征。总之，国际MOGAD标准为MOGAD的统一诊断迈出了一大步。未来可能会认识到MOGAD的其他临床特征，以扩大MOGAD的表型，但验证更罕见的非典型表现将是重要的，因为MOG-IgG结果可能出现假阳性，特别是在低MOG-IgG滴度的低检测前概率情况下。老年性黄斑变性患者痴呆或阿尔茨海默病的风险增加蔡宏辉，罗瑞瑞，梁洪，陈立林，黄洪，王建辉，李玉成。年龄相关性黄斑变性患者随后痴呆或阿尔茨海默病的风险:一项系统综述和荟萃分析中华眼科杂志，2009;37(4):391 - 391。作者进行了一项系统回顾和荟萃分析，以阐明老年性黄斑变性(AMD)与172 D. a . BELLOWS等人的关系。
{"title":"Neuro-Ophthalmic Literature Review","authors":"D. Bellows, N. Chan, John J. Chen, Hui-Chen Cheng, P. Jindahra, P. Macintosh, Collin M. McClelland, M. Vaphiades, Xiaojun Zhang","doi":"10.1080/01658107.2023.2201136","DOIUrl":"https://doi.org/10.1080/01658107.2023.2201136","url":null,"abstract":"Neuro-Ophthalmic Literature Review David A. Bellows, Noel C. Y. Chan, John J. Chen, Hui-Chen Cheng, Panitha Jindahra, Peter W. MacIntosh, Collin McClelland, Michael S. Vaphiades, and Xiaojun Zhang The Medical Eye Center, Manchester, New Hampshire, USA; Department of Ophthalmology & Visual Sciences, Prince of Wales Hospital & Alice Ho Miu Ling Nethersole Hospital, Hong Kong; Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong; Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, Minnesota, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Ophthalmology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Neurology, Mahidol University, Bangkok, Thailand; Department of Ophthalmology, Illinois Ear and Eye Infirmary, Chicago, Illinois, USA; Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota, USA; Departments of Ophthalmology, Neurology, and Neurosurgery, UAB Callahan Eye Hospital, Birmingham, Alexandria, USA; Department of Neurology, Ohio State University Medical Center, Columbus, Ohio, USA; Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, Hebei, China Peripapillary Hyperreflective Ovoid Mass-Like Structures: Multimodal Imaging – A Review Jeffery RCH, Chen FK. Peripapillary hyperreflective ovoid mass-like structures: Multimodal imaging-A review. Clin Exp Ophthalmol. 2023;51:67–80. Prior to the establishment of the Optic Disk Drusen Consortium the ovoid peripapillary structures detected on optical coherence tomography (OCT) were felt to be buried optic disk drusen. These structures have since been redefined as peripapillary hyperreflective ovoid mass-like structures (PHOMS) and identified as a manifestation of axoplasmic stasis. The authors discuss the characteristic findings of PHOMS on multimodal OCT and review the literature pertaining to the co-existence of PHOMS with diseases other than optic disk drusen. These include papilloedema, anterior ischaemic optic neuropathy, tilted disk syndrome, inflammatory demyelinating disorders as well as retinal and orbital diseases. David Bellows Anti-Hypertensive Medications – Before Bed or Not? Labowsky MT, Rizzo III JF. The controversy of chronotherapy: Emerging evidence regarding bedtime dosing of antihypertensive medications in non-arteritic anterior ischaemic optic neuropathy. Semin Ophthalmol. 2023;38:99–104. This is a review article highlighting the marked conflict between therapeutic recommendations published in the ophthalmology and cardiology literature, with the former arguing against taking anti-hypertensive medications at bedtime to reduce risk of sequential non-arteritic anterior ischaemic optic neuropathy (NAION) while the latter arguing in favour of bedtime dosing to reduce the risk of cardiovascular disease (CVD). The observation of “blinding upon awakening” in patients with NAION has prom","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"11 1","pages":"171 - 176"},"PeriodicalIF":0.8,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79995194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-02DOI: 10.1080/01658107.2023.2169555
D. Bellows, John J. Chen, Hui-Chen Cheng, P. Jindahra, Collin M. McClelland, M. Vaphiades, Xiaojun Zhang
Neuro-Ophthalmic Literature Review David A. Bellows, John J. Chen, Hui-Chen Cheng, Panitha Jindahra, Collin McClelland, Michael S. Vaphiades, and Xiaojun Zhang The Medical Eye Center, Manchester, New Hampshire, USA; Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, MN, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Ophthalmology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Neurology, Mahidol University, Bangkok, Thailand; Department of Ophthalmology, University of Minnesota, Minneapolis, MN, USA; Departments of Ophthalmology, Neurology, and Neurosurgery, UAB Callahan Eye Hospital, Birmingham, AL, USA; Department of Neurology, Ohio State University Medical Center, Ohio, USA; Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China Oral fluorescein angiography for the diagnosis of papilloedema versus pseudopapilledema in children Elhusseiny AM, Fong JW, Hsu C, Grigorian F, Grigorian AP, Soliman MK, et al. Oral fluorescein angiography for the diagnosis of papilloedema versus pseudopapilledema in children. Am J Ophthalmol 2023;245: 8–13. This study was designed to determine if the use of oral fluorescein angiography is accurate and safe in differentiating papilloedema from pseudopapilloedema in paediatric patients. Two masked specialists (a paediatric ophthalmologist and retina specialist) reviewed the oral fluorescein angiogram images of 45 patients (90 eyes). They evaluated the optic discs and assigned them to three categories: leakage; no leakage; or “borderline” leakage of fluorescein, at least 30 minutes following ingestion of the medication. The determinations made by the masked observers were then compared with the final clinical diagnosis. There was excellent interobserver accordance in grading the images. Oral fluorescein angiography was found to be safe with no ocular, systemic or allergic reactions. The accuracy, however, was suboptimal with only 62 to 69% of images accurately differentiating papilloedema from pseudopapilloedema. However, the sensitivity at detecting leakage increased with the severity of disc swelling and the observers correctly identified papilloedema in 89% of patients who had Frisén grade 2 or 3 swelling. David Bellows Enhanced depth imaging may be the new gold standard for detecting optic disc drusen Youn S, Mfe B, Armstrong JJ, Fraser JA, Hamann S, Bursztyn L. Am J Ophthalmol. 11 December 2022: S0002-9394(22)00485–8. doi: 10.1016/j.ajo.2022. 12.004. Online ahead of print.
David A. Bellows, John J. Chen，程慧琛，Panitha Jindahra, Collin McClelland, Michael S. Vaphiades, Xiaojun Zhang美国曼彻斯特医学眼科中心;美国明尼苏达州罗彻斯特市梅奥诊所眼神经内科;台北荣民总医院眼科，台湾台北;国立阳明交通大学医学院眼科，台湾台北;泰国曼谷玛希隆大学神经内科;明尼苏达大学眼科，明尼阿波利斯，MN，美国;UAB Callahan眼科医院眼科、神经内科和神经外科，伯明翰，AL，美国;美国俄亥俄州俄亥俄州立大学医学中心神经内科;口服荧光素血管造影诊断儿童乳头状水肿与假性乳头状水肿Elhusseiny AM, Fong JW, Hsu C, Grigorian F, Grigorian AP, Soliman MK等口腔荧光素血管造影诊断儿童乳头状水肿与假性乳头状水肿。中华眼科杂志，2009;24(3):391 - 391。本研究旨在确定使用口服荧光素血管造影在鉴别儿科患者乳头状水肿和假性乳头状水肿时是否准确和安全。两名蒙面专家(一名儿科眼科医生和一名视网膜专家)审查了45名患者(90只眼睛)的口腔荧光素血管造影图像。他们对视盘进行了评估，并将其分为三类:渗漏;无渗漏;或在服药后至少30分钟出现荧光素“边缘性”渗漏。然后将蒙面观察员所作的决定与最终的临床诊断进行比较。在对图像进行分级时，观察者之间的一致性非常好。口服荧光素血管造影是安全的，没有眼部、全身或过敏反应。然而，准确度是次优的，只有62%到69%的图像能准确区分乳头状水肿和假乳头状水肿。然而，检测渗漏的敏感性随着椎间盘肿胀的严重程度而增加，观察人员在89%的fris 2级或3级肿胀患者中正确识别了乳头状水肿。杨建军，张建军，李建军，等。深度增强成像技术在视盘病变诊断中的应用[J] .中国眼科杂志，2016,31(2):559 - 559。doi: 10.1016 / j.ajo.2022。12.004. 先在线，后印刷。
{"title":"Neuro-Ophthalmic Literature Review","authors":"D. Bellows, John J. Chen, Hui-Chen Cheng, P. Jindahra, Collin M. McClelland, M. Vaphiades, Xiaojun Zhang","doi":"10.1080/01658107.2023.2169555","DOIUrl":"https://doi.org/10.1080/01658107.2023.2169555","url":null,"abstract":"Neuro-Ophthalmic Literature Review David A. Bellows, John J. Chen, Hui-Chen Cheng, Panitha Jindahra, Collin McClelland, Michael S. Vaphiades, and Xiaojun Zhang The Medical Eye Center, Manchester, New Hampshire, USA; Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, MN, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Ophthalmology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Neurology, Mahidol University, Bangkok, Thailand; Department of Ophthalmology, University of Minnesota, Minneapolis, MN, USA; Departments of Ophthalmology, Neurology, and Neurosurgery, UAB Callahan Eye Hospital, Birmingham, AL, USA; Department of Neurology, Ohio State University Medical Center, Ohio, USA; Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China Oral fluorescein angiography for the diagnosis of papilloedema versus pseudopapilledema in children Elhusseiny AM, Fong JW, Hsu C, Grigorian F, Grigorian AP, Soliman MK, et al. Oral fluorescein angiography for the diagnosis of papilloedema versus pseudopapilledema in children. Am J Ophthalmol 2023;245: 8–13. This study was designed to determine if the use of oral fluorescein angiography is accurate and safe in differentiating papilloedema from pseudopapilloedema in paediatric patients. Two masked specialists (a paediatric ophthalmologist and retina specialist) reviewed the oral fluorescein angiogram images of 45 patients (90 eyes). They evaluated the optic discs and assigned them to three categories: leakage; no leakage; or “borderline” leakage of fluorescein, at least 30 minutes following ingestion of the medication. The determinations made by the masked observers were then compared with the final clinical diagnosis. There was excellent interobserver accordance in grading the images. Oral fluorescein angiography was found to be safe with no ocular, systemic or allergic reactions. The accuracy, however, was suboptimal with only 62 to 69% of images accurately differentiating papilloedema from pseudopapilloedema. However, the sensitivity at detecting leakage increased with the severity of disc swelling and the observers correctly identified papilloedema in 89% of patients who had Frisén grade 2 or 3 swelling. David Bellows Enhanced depth imaging may be the new gold standard for detecting optic disc drusen Youn S, Mfe B, Armstrong JJ, Fraser JA, Hamann S, Bursztyn L. Am J Ophthalmol. 11 December 2022: S0002-9394(22)00485–8. doi: 10.1016/j.ajo.2022. 12.004. Online ahead of print.","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"142 1","pages":"123 - 127"},"PeriodicalIF":0.8,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83042651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-02DOI: 10.1080/01658107.2022.2155453
D. Bellows, N. Chan, John J. Chen, Hui-Chen Cheng, P. Macintosh, Collin M. McClelland, M. Vaphiades, K. Weber, Xiaojun Zhang
Neuro-Ophthalmic Literature Review David A. Bellows, Noel C.Y. Chan, John J. Chen , Hui-Chen Cheng, Peter W MacIntosh, Collin McClelland, Michael S. Vaphiades, Konrad P. Weber, and Xiaojun Zhang The Medical Eye Center, Manchester, New Hampshire, USA; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital & Alice Ho Miu Ling Nethersole Hospital, Hong Kong, Hong Kong; Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong; Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, Minnesota, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Ophthalmology, School of Medicine National Yang Ming Chiao Tung University Hsinchu Taiwan; Department of Ophthalmology, Illinois Ear and Eye Infirmary, Chicago, Illinois, USA; Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota, USA; Departments of Ophthalmology, Neurology, and Neurosurgery, UAB Callahan Eye Hospital, Birmingham, Alabama, USA; Departments of Neurology and Ophthalmology, University Hospital Zurich, Zürich, Switzerland; Department of Neurology, Ohio State University Medical Center, Columbus, Ohio, USA; Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, Hebei, China Analysis of facial features of patients with sagging eye syndrome and intermittent exotropia compared to controls Kunimi K, Goseki T, Fukaya K, Takahashi S, Ishikawa E, et al. Analysis of facial features of patients with sagging eye syndrome and intermittent exotropia compared to controls. Am J Ophthalmol 18 October 2022;S0002-9394(22)00391–9. doi: 10.1016/j.ajo.2022.10.007. Online ahead of print. Frontal facial photographs of patients who were greater than 60 years of age and had been diagnosed with sagging eye syndrome or intermittent exotropia were evaluated for three characteristics including sunken upper eyelids, blepharoptosis and baggy lower eyelids. The patients were compared to normal controls and a scoring system was used to grade the degree of these three characteristics. A total of 86 patients were included in the study. Of these, 23 were diagnosed with sagging eye syndrome, 28 were diagnosed with intermittent exotropia and 35 were in the control group. All patients were Japanese. The authors noted that only sunken upper eyelids, as opposed to blepharoptosis and baggy lower eyelids, were significantly associated with sagging eye syndrome. This contrasts with previous reports of sagging eye syndrome being associated with blepharoptosis. They also report that baggy lower eyelids were significantly associated with intermittent exotropia. A detailed description is provided of the pathological changes that occur within the orbit leading to these two disorders. David Bellows Serial titre and seroconversion in paediatric myelin oligodendrocyte glycoprotein antibody
神经眼科文献综述David A. Bellows, Noel C.Y. Chan, John J. Chen, Cheng -Chen, Peter W . MacIntosh, Collin McClelland, Michael S. Vaphiades, Konrad P. Weber, Xiaojun Zhang美国曼彻斯特医学眼科中心香港威尔斯亲王医院及何妙龄那打素医院眼科及视觉科学部;香港中文大学眼科及视觉科学系，香港;美国明尼苏达州罗彻斯特梅奥诊所眼神经内科;台北荣民总医院眼科，台湾台北;台湾新竹国立阳明交通大学医学院眼科;美国伊利诺斯州芝加哥伊利诺斯耳眼医院眼科;美国明尼苏达州明尼阿波利斯市明尼苏达大学眼科;美国阿拉巴马州伯明翰市UAB Callahan眼科医院眼科、神经内科和神经外科;瑞士苏黎世大学医院神经内科和眼科;美国俄亥俄州哥伦布市俄亥俄州立大学医学中心神经内科;首都医科大学附属北京同仁医院神经内科与对照组对比分析眼下垂综合征合并间歇性外斜视患者的面部特征Kunimi K, Goseki T, Fukaya K, Takahashi S, Ishikawa E等眼下垂综合征和间歇性外斜视患者与对照组的面部特征分析。中华眼科杂志2018年10月18日;S0002-9394(22) 00391-9。doi: 10.1016 / j.ajo.2022.10.007。先在线，后印刷。年龄大于60岁且被诊断为眼下垂综合征或间歇性外斜视的患者的正面面部照片被评估为三个特征，包括上眼睑凹陷，上睑下垂和下眼睑松弛。将患者与正常对照进行比较，并使用评分系统对这三个特征的程度进行分级。研究共纳入86例患者。其中23人被诊断为眼下垂综合征，28人被诊断为间歇性外斜视，35人被诊断为对照组。所有患者均为日本人。作者指出，与上眼睑下垂和下眼睑松弛相反，只有上眼睑凹陷与眼下垂综合征有显著关系。这与之前报道的眼部下垂综合征与上睑下垂有关形成对比。他们还报告说，松弛的下眼睑与间歇性外斜视显著相关。详细描述了眼眶内发生的病理变化导致这两种疾病。儿童髓鞘少突胶质细胞糖蛋白抗体的连续滴度和血清转化
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Pub Date : 2022-12-15DOI: 10.1080/01658107.2022.2143532
Shira S. Simon
Drs Gologorsky and Rosen have created a beautifully illustrated, high yield text that ought to become a standard reference for the field of ophthalmology. Offering a concise and comprehensive guide to 22 ocular imaging modalities in just over 200 pages, Principles of Ocular Imaging is meticulously organised from anterior to posterior, with clear divisions for the various specialities. Each section has pages filled with vibrant, high-resolution images of classic patient presentations. Accompanying each photograph are succinct descriptions of critical information for each disease process and the suggested imaging approach. The language is clear and would be helpful at all stages of training and practice as a primer or refresher. In terms of the structure of the book, the main sections are oculoplastics, cornea and refractive, retina, glaucoma, and neuroophthalmology. Now, several years away from my ophthalmology residency, I found the cornea and retina sections’ more recent updates particularly elucidating, from the applications of anterior segment optical coherence tomography (OCT) as a ‘light biopsy’ tool in cornea, to the many uses of OCT angiography and adaptive optics in retinal practice. The key topics discussed in each section are:
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Pub Date : 2022-09-03DOI: 10.1080/01658107.2022.2132065
D. Bellows, N. Chan, John J. Chen, Hui-Chen Cheng, P. Macintosh, M. Vaphiades, K. Weber, Xiaojun Zhang
Neuro-Ophthalmic Literature Review David A. Bellows, Noel C. Y. Chan, John J. Chen, Hui-Chen Cheng, Peter W. MacIntosh, Michael S. Vaphiades, Konrad P. Weber, and Xiaojun Zhang The Medical Eye Center, Manchester, New Hampshire, USA; Department of Ophthalmology & Visual Sciences, Prince of Wales Hospital & Alice Ho Miu Ling Nethersole Hospital, Hong Kong; Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong; Departments of Ophthalmology and Neurology, Mayo Clinic, Rochester, Minnesota, USA; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan. Department of Ophthalmology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Ophthalmology, Illinois Ear and Eye Infirmary, Chicago, Illinois, USA; Departments of Ophthalmology, Neurology, and Neurosurgery, UAB Callahan Eye Hospital, Birmingham, AL, USA; Departments of Neurology and Ophthalmology, University Hospital Zurich, Zürich, Switzerland; Department of Neurology, Ohio State University Medical Center, Ohio, USA. Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China Oculomotor Nerve Schwannoma: Case Series and Literature Review Douglas VP, Flores C, Douglas KA, Strominger MB, Kasper E, Torun N. Oculomotor nerve schwannoma: Case series and literature review. Surv Ophthalmol. 2022 Jul–Aug;67(4):1160–1174. There have only been 100 reported cases of oculomotor nerve schwannoma and, due to its rarity, there is no established guideline for the management of these tumours. Based on a review of the literature and their own cases, the authors have developed an algorithm that addresses the indications for treatment and their outcomes Eighty-four cases of oculomotor nerve schwannoma reported between 1980 and 2020 were included in this review. The mean age at diagnosis was 32.7 years (range 2 months to 78 years) with a male-to-female ratio of 2:3. Four of these patients were asymptomatic. The remaining patients reported symptoms of third nerve palsy including diplopia (n = 24) and ptosis (n = 30). Twenty-three of the patients experienced symptoms suggestive of ophthalmoplegic migraine with headache followed by brief periods of diplopia or ptosis. Other symptoms included those related to the mass effect of the tumour including cognitive changes, periorbital pain, and nausea. Patients with larger tumours (mean 27.3 mm) were primarily treated surgically, which frequently resulted in a complete palsy of the third nerve. Patients with smaller tumours did well with stereotactic radiosurgery, which resulted in a reduction in tumour size with no worsening of symptoms. Considering the above findings, the authors proposed the following algorithm. Patients who are asymptomatic can be monitored with no intervention. Patients with smaller tumours, who are symptomatic, can be treated with stereotactic radiosurgery followed by the prescription of spectacles containing a prismatic co
虽然骨眶的尺寸在检查组之间有显著差异，但在TED患者中发生DON的易感因素没有差异。TED+DON患者眶壁内侧角度的改变可能是MR增大的代偿机制，而不是DON发展的罪魁祸首。然而，内侧壁弯曲的增加可以作为肌肉体积增加的替代参数。虽然在这项研究中，大多数表现出DON的受试者肌肉体积明显增加，但在散点图数据中，一小部分受试者没有或几乎没有增加。尽管存在相关性，但仅凭肌肉体积和眼眶评估数据不足以区分TED患者的DON和非DON眼眶。这证实了这种疾病具有几种现有亚型的异质性，这需要额外的成像方式来描述。磁共振成像或正电子发射断层扫描可以更好地研究眼外肌的功能和形态学参数，其中炎症可以突出显示。在我们可以依靠放射检查来对TED患者DON发展的风险进行分层之前，定期的神经眼科监测和视野检查仍然是强制性的。Eshraghi B, Moayeri M, Pourazizi M, Rajabi MT, Rafizadeh M.甲状腺相关性眼病下眶壁和内侧眶壁减压后Bell现象减少:治疗患者的双刃剑。中华眼科杂志，2016,31(5):563 - 563。下直肌(IR)是影响甲状腺相关性眼窝病(TAO) Bell’s现象的主要眼窝肌。限制性肌病的IR纤维母细胞挛缩可能导致TAO患者的贝尔反射降低。在这组患者中，暴露性角膜病变连同严重的眼球突出可能导致视力丧失。除了药物治疗和放射治疗外，中重度TAO患者有时还需要眼眶壁减压。这是一项前瞻性研究，评估30例TAO患者眶下壁和眶内壁减压后贝尔氏现象的变化。结果在手术前和术后6个月的基线进行比较。术后贝尔现象的距离平均减少3.25±1.57 mm (p < 0.001)。调整后的贝尔现象也加重了1.58±2.13 mm (p < 0.001)。尽管术后突出眼明显减少(24.3±3.06 mm至22.3±2.27 mm, p < 0.001)，但减压后角膜染色平均评分无统计学差异。下壁和内壁眶壁减压后Bell现象的恶化，假设是由于IR和周围软组织脱垂到打开的窦内，导致运动障碍。这项研究在术后发现了升高缺陷的增加，这一点得到了支持。未来的研究需要评估单独内侧壁减压或不干预下侧壁减压后贝尔现象的变化来证实这一假设。无论如何，临床医生必须提醒患者眶内壁减压后的潜在并发症，并在出现爆裂性骨折的患者中寻找类似的后遗症。Noel Chan 352摘要
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Pub Date : 2022-09-03DOI: 10.1080/01658107.2022.2108849
H. Ishikawa
After graduating from the Tohoku University School of Medicine in 1957 Dr Satoshi Ishikawa (Figure 1) joined the Department of Ophthalmology of the University of Tokyo School of Medicine. In 1958 he became an assistant professor at the Department of Ophthalmology, School of Medicine, University of Tokyo. In 1963 he was awarded a Fulbright Fellowship to study at the New York University. Two years later he became an associate professor there. After returning to Japan in 1965 he became a lecturer at the Department of Ophthalmology, Tokyo University Medical School. In 1971 he was appointed as the first department head of the Ophthalmology Department at the Kitasato University School of Medicine and served as the dean in 1994, the Director of the Kitasato Institute Hospital Environmental Centre in 1998, and Advisor at the Kitasato Institute in 2005. During his initial tenure at the University of Tokyo Dr Ishikawa was interested in Neuroophthalmology, strabismus/amblyopia, and toxicology. He continued in clinical and research work, mainly in these fields, at the New York University. For these endeavours he returned home after having numerous achievements. In 1959 he established the Japan Neuro-ophthalmology Group, which served as the foundation for the Japanese Society of Neuroophthalmology. Moreover, he developed the field of toxicology and focused on the chronic toxicity of organophosphorus. He wrote a paper on the effects of anticholinesterase drugs on esotropia and myasthenia gravis, the point of contact between Neuro-ophthalmology, strabismus/myopia, and toxicology. In 1968 he was awarded the 7th General Medicine Award for ‘Esotropia and Miotic Agents’, and in 1975 the 28th General Medicine Award for ‘Ocular Symptoms of Myasthenia Gravis and Cholinesterase’. Dr Ishikawa remained active in the development of electronic pupillometers and he later perfected the infrared electronic pupillometer, which has been applied in the clinical setting. His research and clinical works went beyond the field of Ophthalmology, covering topics such as visual display terminal syndrome, sick house syndrome, and chemical sensitivity. He also served as the chairman of the scientific research committee of the Ministry of Health, Labour, and Welfare. In 1996 he delivered a special commemorative lecture at the 31st Annual Meeting of the American Academy of Environmental Medicine, where he was the first Japanese recipient of the Jonathan Forman Award. He also received the Japanese Ophthalmological Society Award in 1998 for his ‘Research on Ocular Toxicity of Organophosphorus’. Dr Ishikawa received the Japanese Ophthalmological Society Special Contribution Award in 2003 for his brilliant feats in the development of ophthalmic science. He actively pioneered the field of Neuroophthalmology in Japan by establishing the Japanese Society of Neuro-ophthalmology. He also served as councillor and director of the Japanese Ophthalmological Society, honorary member and director of the
{"title":"Dr Satoshi Ishikawa (1932-2022)","authors":"H. Ishikawa","doi":"10.1080/01658107.2022.2108849","DOIUrl":"https://doi.org/10.1080/01658107.2022.2108849","url":null,"abstract":"After graduating from the Tohoku University School of Medicine in 1957 Dr Satoshi Ishikawa (Figure 1) joined the Department of Ophthalmology of the University of Tokyo School of Medicine. In 1958 he became an assistant professor at the Department of Ophthalmology, School of Medicine, University of Tokyo. In 1963 he was awarded a Fulbright Fellowship to study at the New York University. Two years later he became an associate professor there. After returning to Japan in 1965 he became a lecturer at the Department of Ophthalmology, Tokyo University Medical School. In 1971 he was appointed as the first department head of the Ophthalmology Department at the Kitasato University School of Medicine and served as the dean in 1994, the Director of the Kitasato Institute Hospital Environmental Centre in 1998, and Advisor at the Kitasato Institute in 2005. During his initial tenure at the University of Tokyo Dr Ishikawa was interested in Neuroophthalmology, strabismus/amblyopia, and toxicology. He continued in clinical and research work, mainly in these fields, at the New York University. For these endeavours he returned home after having numerous achievements. In 1959 he established the Japan Neuro-ophthalmology Group, which served as the foundation for the Japanese Society of Neuroophthalmology. Moreover, he developed the field of toxicology and focused on the chronic toxicity of organophosphorus. He wrote a paper on the effects of anticholinesterase drugs on esotropia and myasthenia gravis, the point of contact between Neuro-ophthalmology, strabismus/myopia, and toxicology. In 1968 he was awarded the 7th General Medicine Award for ‘Esotropia and Miotic Agents’, and in 1975 the 28th General Medicine Award for ‘Ocular Symptoms of Myasthenia Gravis and Cholinesterase’. Dr Ishikawa remained active in the development of electronic pupillometers and he later perfected the infrared electronic pupillometer, which has been applied in the clinical setting. His research and clinical works went beyond the field of Ophthalmology, covering topics such as visual display terminal syndrome, sick house syndrome, and chemical sensitivity. He also served as the chairman of the scientific research committee of the Ministry of Health, Labour, and Welfare. In 1996 he delivered a special commemorative lecture at the 31st Annual Meeting of the American Academy of Environmental Medicine, where he was the first Japanese recipient of the Jonathan Forman Award. He also received the Japanese Ophthalmological Society Award in 1998 for his ‘Research on Ocular Toxicity of Organophosphorus’. Dr Ishikawa received the Japanese Ophthalmological Society Special Contribution Award in 2003 for his brilliant feats in the development of ophthalmic science. He actively pioneered the field of Neuroophthalmology in Japan by establishing the Japanese Society of Neuro-ophthalmology. He also served as councillor and director of the Japanese Ophthalmological Society, honorary member and director of the ","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"20 1","pages":"349 - 350"},"PeriodicalIF":0.8,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82629558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-04DOI: 10.1080/01658107.2022.2058803
D. Bellows, N. Chan, John J. Chen, Hui-Chen Cheng, P. Macintosh, M. Vaphiades, Xiaojun Zhang
is an inflammatory demyelinating disease affecting the central nervous system, which most commonly causes optic neuritis, transverse myelitis, and area postrema syndrome. Antibodies directed against aquaporin 4, a water channel expressed on the astrocytic membrane, are detected in approximately 80% of cases. In this article, the authors discuss a case of a 76-year-old woman with a 2-month history of confusion, dysar-thria, and progressive bilateral leg weakness, which was associated with adenocarcinoma. They conclude that signs of NMOSD in elderly patients should arouse the suspicion of a paraneoplastic aetiology. The authors report an 11-year-old girl who noted gradual visual loss in the right eye for 1 year to 20/100 in the right eye, compared with 20/ 20 in the left eye, with subfoveal yellow deposits in both eyes. Optical coherence tomography, electro-oculography, electro-retinography and colour fundus photographs illustrate the findings,which were in-keeping with Best’s disease, the second most common hereditary macular dystrophy. It is char-acterised by the accumulation of lipofuscin-like materials on the retinal pigment epithelium cell-photoreceptor interface. The disorder’s associated mutations may contribute to apoptosis of the retinal pigment epithelial cells by targeting Caspase-3 (a protein encoded by the CAPS3 gene) that may be one of the mechanisms in bestrophinopathies. and T1-WI A chi-square test used compare both sequences and the inter-rater agreement was calculated. Results : Thirty-five magnetic resonance imaging (MRI) sessions were performed before treatment, including 19 post-contrast FLAIR in 17 patients and 25 post-contrast T1-WIs in 19 patients. In terms of patients, LME was on all 17 post-contrast FLAIR images versus post-contrast T1-WIs < In LME on all post-contrast FLAIR versus 16/25 of post-contrast T1-WIs < LME disseminated both and infratentorial post-contrast FLAIR, compared post-contrast Inter-rater
{"title":"Neuro-Ophthalmic Literature Review","authors":"D. Bellows, N. Chan, John J. Chen, Hui-Chen Cheng, P. Macintosh, M. Vaphiades, Xiaojun Zhang","doi":"10.1080/01658107.2022.2058803","DOIUrl":"https://doi.org/10.1080/01658107.2022.2058803","url":null,"abstract":"is an inflammatory demyelinating disease affecting the central nervous system, which most commonly causes optic neuritis, transverse myelitis, and area postrema syndrome. Antibodies directed against aquaporin 4, a water channel expressed on the astrocytic membrane, are detected in approximately 80% of cases. In this article, the authors discuss a case of a 76-year-old woman with a 2-month history of confusion, dysar-thria, and progressive bilateral leg weakness, which was associated with adenocarcinoma. They conclude that signs of NMOSD in elderly patients should arouse the suspicion of a paraneoplastic aetiology. The authors report an 11-year-old girl who noted gradual visual loss in the right eye for 1 year to 20/100 in the right eye, compared with 20/ 20 in the left eye, with subfoveal yellow deposits in both eyes. Optical coherence tomography, electro-oculography, electro-retinography and colour fundus photographs illustrate the findings,which were in-keeping with Best’s disease, the second most common hereditary macular dystrophy. It is char-acterised by the accumulation of lipofuscin-like materials on the retinal pigment epithelium cell-photoreceptor interface. The disorder’s associated mutations may contribute to apoptosis of the retinal pigment epithelial cells by targeting Caspase-3 (a protein encoded by the CAPS3 gene) that may be one of the mechanisms in bestrophinopathies. and T1-WI A chi-square test used compare both sequences and the inter-rater agreement was calculated. Results : Thirty-five magnetic resonance imaging (MRI) sessions were performed before treatment, including 19 post-contrast FLAIR in 17 patients and 25 post-contrast T1-WIs in 19 patients. In terms of patients, LME was on all 17 post-contrast FLAIR images versus post-contrast T1-WIs < In LME on all post-contrast FLAIR versus 16/25 of post-contrast T1-WIs < LME disseminated both and infratentorial post-contrast FLAIR, compared post-contrast Inter-rater","PeriodicalId":19257,"journal":{"name":"Neuro-Ophthalmology","volume":"94 1","pages":"208 - 214"},"PeriodicalIF":0.8,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85373639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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