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Mining the Human Metabolome for Precision Oncology Research 挖掘人类代谢组,促进精准肿瘤学研究
Mercy E. Edoho, M. Ekpenyong, Aliu B. Momodu, Geoffery Joseph
Access to clinical data is critical for advancing translational research; but regulatory constraints and policies surrounding the use of clinical data often challenge data access and sharing. Mixed medical datasets (structured and unstructured) are increasingly dominating the clinical information space, hence, demanding AI-driven techniques such as Natural Language Processing-to reorganize them for effective usage. This paper excavates the HMDB (Human Metabolome Database), for efficient knowledge mining, supported by diversely certified oncology physicians and pharmacists' contributions. We propose a novel taxonomy for knowledge representation and establish a universe of discourse for disease clustering and prediction. Excavated data include metabolites and their respective concentration values, age, gender, as well as gene and protein sequences, of normal and abnormal patients. These data were then merged to form an AI-ready 'Omic' technology datasets. Preliminary results reveal that the proposed AI-ready datasets would aid precision oncology research by adding quality analysis to the present HMDB, and for explaining the variations in concentration values of cancer patients.
获取临床数据对于推进转化研究至关重要;但围绕临床数据使用的监管限制和政策往往对数据的获取和共享构成挑战。混合医学数据集(结构化和非结构化)在临床信息领域日益占据主导地位,因此需要人工智能驱动的技术(如自然语言处理)对其进行重组,以便有效利用。本文挖掘了 HMDB(人类代谢组数据库),以进行高效的知识挖掘,并由经过认证的不同肿瘤学医生和药剂师提供支持。我们提出了一种新颖的知识表征分类法,并建立了疾病聚类和预测的话语体系。挖掘出的数据包括正常和异常患者的代谢物及其各自的浓度值、年龄、性别以及基因和蛋白质序列。然后将这些数据合并起来,形成一个可用于人工智能的 "Omic "技术数据集。初步结果显示,建议的人工智能就绪数据集将有助于精准肿瘤学研究,为现有的 HMDB 增加质量分析,并解释癌症患者浓度值的变化。
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引用次数: 3
Correlation Between Pharmacokinetic Analysis of DCE-MRI and Breast Image Reporting and Data System (BIRADS) Classification DCE-MRI药代动力学分析与乳腺图像报告和数据系统(BIRADS)分类的相关性
Xia Wu, Yulong Qi, Fei Feng, Guanxun Cheng, N. Zhang
To determine if pharmacokinetic information derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) could improve the diagnostic value of breast disease. A total of thirty-six female patients (range, 30-70 years, mean 48.1±12.6 years) confirmed BIRADS 3~6 underwent DCE-MRI were retrospectively recruited to this study. Modified two-compartment Tofts model and Brix mode were used to obtain relevant tracer kinetic parameters. Mann-Whitney U-test was used to compare the parameters between the BIRADS 3 and 4, BIRADS 4 and 5, BIRADS 5 and 6, respectively. A P value of less than 0.05 was considered to indicate a significant difference. In evaluating significance between BIRADS 3 and BIRADS 4, the statistical analysis showed that Brix-kep (P=0.014), ABrix (P<0.001), TTP (P=0.022) were independent factors associated with the discrepancy. All kinetic parameters we calculated were independent factors associated with the discrepancy between BIRADS 4 and BIRADS 5. ABrix (AUC=0.915) do have a good discriminative power between BIRADS 3 and 4. Tofts-kep (AUC= 0.952), ABrix (AUC= 0.990) do have a good discriminative power between BIRADS 4 and 5.The numeric values of Brix-kep, Brix-kel, ABrix, Tofts-ktrans, Tofts-kep and Slope were higher in high grades (BIRADS 5 and BIRADS 6) than in low grades (BIRADS 3 and BIRADS 4) tumors. ABrix have a good discriminative power between BIRADS 3 and 4. Tofts-kep, ABrix do have a good discriminative power between BIRADS 4 and 5. No significant difference between BIRADS 5 and 6.
目的探讨动态增强磁共振成像(DCE-MRI)的药代动力学信息是否能提高乳腺疾病的诊断价值。回顾性招募36例经DCE-MRI证实BIRADS 3~6的女性患者(年龄30 ~ 70岁,平均48.1±12.6岁)。采用改进的双室Tofts模型和Brix模型获得了相关的示踪剂动力学参数。采用Mann-Whitney u检验分别比较BIRADS 3与4、BIRADS 4与5、BIRADS 5与6的参数。P值小于0.05为差异有统计学意义。在评价BIRADS 3与BIRADS 4之间的显著性时,统计学分析显示Brix-kep (P=0.014)、ABrix (P<0.001)、TTP (P=0.022)是导致差异的独立因素。我们计算的所有动力学参数都是与BIRADS 4和BIRADS 5差异相关的独立因素。ABrix (AUC=0.915)在BIRADS 3和BIRADS 4之间有很好的判别能力。tofts - keep (AUC= 0.952)和ABrix (AUC= 0.990)在BIRADS 4和BIRADS 5之间具有较好的判别能力。brix - keep、Brix-kel、ABrix、Tofts-ktrans、tofts - keep和Slope的数值在高分级(BIRADS 5和BIRADS 6)肿瘤中高于低分级(BIRADS 3和BIRADS 4)肿瘤。ABrix对BIRADS 3和BIRADS 4具有较好的判别能力。尽管如此,ABrix在BIRADS 4和BIRADS 5之间确实有很好的区分能力。BIRADS 5和6之间无显著差异。
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引用次数: 0
Research and Design of Atrial Fibrillation Early Warning Service System Based on Mobile Internet 基于移动互联网的房颤预警服务系统研究与设计
Ling Yan, Zuojian Zhou, Xuhao Sun, Yihua Song, Yamei Bai
Atrial fibrillation is closely related to hypertension. In view of the few studies on the combination of atrial fibrillation and blood pressure, an atrial fibrillation sphygmomanometer which can measure both atrial fibrillation and blood pressure simultaneously is developed. Meanwhile, a cloud platform for atrial fibrillation early warning service and a discriminant model for atrial fibrillation are built. Supported by mobile Internet, Internet of Things and cloud computing, with atrial fibrillation and hypertension as the research object, an atrial fibrillation model was established by mixing circulating neural network (RNN) and short-term memory network (LSTM). Then we applied the model to MIT-BIH Atrial Fibrillation Database and results verified that the accuracy is as high as 98.9%. Finally, to make the system more comprehensive, we developed patient-side and physician-side APPs, including atrial fibrillation recognition, physician teleservice and health care recommendations, and doctors monitor patient synopsis in real time and provide personalized medical services.
心房颤动与高血压密切相关。针对目前关于房颤与血压结合的研究较少,研制了一种同时测量房颤和血压的房颤血压计。同时,建立了房颤预警服务云平台和房颤判别模型。以移动互联网、物联网和云计算为支撑,以房颤和高血压为研究对象,采用循环神经网络(RNN)和短期记忆网络(LSTM)混合方法建立房颤模型。然后将该模型应用于MIT-BIH心房颤动数据库,结果验证准确率高达98.9%。最后,为了使系统更加全面,我们开发了患者端和医生端app,包括房颤识别、医生远程服务和医疗保健推荐,医生实时监测患者病情概况,提供个性化医疗服务。
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引用次数: 0
Coronary Artery Disease Classification from Photoplethysmographic Signals 冠状动脉疾病的光容积描记信号分类
Shibabroto Banerjee, Pourush Sood, S. Ghose, P. Das
Photoplethysmography is a non-invasive and low-cost modality for assessing blood oxygen and volume variations. It is used extensively by physicians for basic monitoring tasks. These signals, however, as prior work has shown, have a plethora of interesting features and can be used for the diagnosis of several cardiovascular diseases. In this article, we aim to detect Coronary Artery Disease (CAD) using Photoplethysmographic signal features. We outline a simple signal processing method to extract these features. Machine learning-based approaches are then used to train classifiers that detect the presence of cardiac distress based on these features. We observe that the proposed method is effective in detecting CAD in a MIMIC-III, a benchmark data set. The technique can be used for low-cost monitoring of early signs of cardiac diseases.
光容积脉搏波是一种评估血氧和血容量变化的无创、低成本的方法。它被医生广泛用于基本的监测任务。然而,正如先前的工作所表明的那样,这些信号具有大量有趣的特征,可用于几种心血管疾病的诊断。在本文中,我们的目的是检测冠状动脉疾病(CAD)的光容积脉搏波信号特征。我们概述了一种简单的信号处理方法来提取这些特征。然后使用基于机器学习的方法来训练基于这些特征检测心脏窘迫存在的分类器。我们观察到,该方法在MIMIC-III基准数据集中检测CAD是有效的。这项技术可以用于低成本监测心脏病的早期症状。
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引用次数: 1
Multi-label Topic Classification of Patient Generated Content in a Breast-cancer Community Forum 乳腺癌社区论坛中患者生成内容的多标签主题分类
B. Athira, S. M. Idicula, Josette F. Jones
The research community has been noticing the importance of the online forums in healthcare in understanding the nuances of health-related problems. Breast Cancer is the most common malignance among women worldwide and its survival rate is steadily increasing thanks to early diagnosis and timely and effective treatment. Still how they manage the disease and maintain the quality of daily life are worth understanding. And it is in this context that the online posts of patients with breast cancer, discussing several topics, become patient generated content. The multi-label nature with these posts arising out of the combined contents of these posts can bring out a multitude of divulging conclusions. The resulting classification issues of these online posts under various categories of topics is examined in the present work. A semi-supervised multi-label classification, followed by refinement of multiple assignments of labels based on fuzzy logic and a neighborhood technique is proposed in the paper. Multiplicity of labels, occurs during the assignment of labels to clusters based on proximity. While extending the refined label set to a greater number of unlabeled posts clustered on the basis of proximity, it is observed that the proposed method could bring out more information on the description of posts. The results thus convey that the most discussed topic in the posts is about diagnosis, along with tangential reference to adverse drug effect, presumably to offer support in terms of information or viewpoint. The results show how the diverse nature of multiple labels can be effectively harnessed to draw conclusion from the potential of social media posts of patients' experience in critical health problems.
研究界已经注意到在线论坛在了解健康相关问题的细微差别方面的重要性。乳腺癌是全世界妇女中最常见的恶性肿瘤,由于早期诊断和及时有效的治疗,其生存率正在稳步上升。但他们如何控制疾病和维持日常生活质量仍值得了解。正是在这种背景下,乳腺癌患者的在线帖子,讨论了几个话题,成为了患者生成的内容。这些帖子的多标签性质源于这些帖子的综合内容,可以得出许多泄露性的结论。在本工作中审查了这些在线帖子在各种主题类别下的分类问题。本文提出了一种基于模糊逻辑和邻域技术的半监督多标签分类方法,并在此基础上对多个标签的分配进行了改进。标签的多重性,发生在根据邻近度给聚类分配标签的过程中。将改进后的标签集扩展到更多基于接近度聚类的未标记帖子,观察到所提出的方法可以提供更多关于帖子描述的信息。因此,结果表明,帖子中讨论最多的话题是关于诊断的,同时也偶尔提到药物不良反应,可能是为了提供信息或观点方面的支持。研究结果表明,如何有效地利用多重标签的多样性,从社交媒体上关于患者在严重健康问题上的经历的帖子中得出结论。
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引用次数: 0
The Association of Sodium Intake on Sleep Quality and Quality of Life of Hill Tribes in Chiang Rai Province, Northern Thailand 泰国北部清莱省山地部落钠摄入量与睡眠质量和生活质量的关系
Phatcharin Winyangkul, Anusara Pongjanta, Watcharapong Ruankham
Cross-sectional research aimed to assess the prevalence and identifying the association between sodium intake, sleep quality and the Quality of Life (QoL) among hill tribes in Chiang Rai Province. Stratified Random Sampling was used to recruit 2,831 participants from eight hill tribes group. The prevalence of sodium intake more than 2,000 mg/day found that 90.67%. The Pittsburgh Sleep Quality Index (PSQI) reported that half of them (50.6%) had poor sleep quality and most of them had a medium level of quality of life 72.5% (2,054 persons). The univariate analysis found that four factors were significantly associated with sodium intake: Adding sauce, adding seasoning powder, PSQI, QOL respectively. The multiple logistic regression analysis revealed the only low quality of life can predict sodium consumption. This research shows that they should have to receive intervention to reduce sodium intake and emphasize hill tribe population of the low quality of life to find health care alternatives.
横断面研究旨在评估清莱省山地部落中钠摄入量、睡眠质量和生活质量(QoL)之间的患病率和关系。采用分层随机抽样的方法,从8个山地部落群体中招募2831名参与者。钠摄入量超过2000毫克/天的患病率为90.67%。匹兹堡睡眠质量指数(PSQI)报告称,其中一半(50.6%)的睡眠质量较差,72.5%(2054人)的大多数生活质量处于中等水平。单因素分析发现,添加酱料、添加调味粉、PSQI和生活质量4个因素分别与钠摄入量显著相关。多元logistic回归分析显示,只有低生活质量才能预测钠摄入量。这项研究表明,他们应该接受干预,以减少钠的摄入量,并强调山区部落人口的低生活质量,以寻找医疗保健的替代品。
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引用次数: 0
Deformable Deep Network Atherosclerotic Coronary Plaque Recognition of Oct Imaging 变形深网络冠状动脉粥样硬化斑块识别的Oct成像
Chaoyu Sun, Hai Huang, Zhaoliang Wan
Cardiovascular disease results great life and economics threat to the patients and their family members around the world. Optical coherence tomography (OCT) image not only obtains higher resolution and faster image modality to assess coronary vessels, but also provides safer guidance for micro scale medical interventions. Deep learning network frameworks have been considered as a promising approach for pathology feature classification and segmentation of computerized diagnosis. In compare with universal dataset for object recognition, atherosclerotic coronary plaque of different patients usually involves different pathology character and formation modality. Limited samples and weakly labeling always cause plaque mis-classification and evaluation. In order to improve recognition accuracy, a novel regional based fully convolutional network with deformable deep networks has been developed to realize plaque object recognition for OCT images. The deformable convolution and regional of interest pooling can adapt to the anchor scales and offsets change to improve classification precision for different pathology character and formation modality of different patients. Recognition experiments from atherosclerotic coronary plaque image have validated the effectiveness and performance of proposed method.
在世界范围内,心血管疾病对患者及其家庭成员造成了巨大的生命和经济威胁。光学相干断层扫描(OCT)图像不仅可以获得更高的分辨率和更快的成像方式来评估冠状血管,而且可以为微观尺度的医疗干预提供更安全的指导。深度学习网络框架被认为是一种很有前途的计算机诊断病理特征分类和分割方法。与通用的目标识别数据集相比,不同患者的冠状动脉粥样硬化斑块通常具有不同的病理特征和形成方式。有限的样本和薄弱的标记常常导致斑块的错误分类和评估。为了提高识别精度,提出了一种基于区域的可变形深度网络全卷积网络,实现了对OCT图像的斑块目标识别。可变形卷积和区域兴趣池可以适应锚定尺度和偏移量的变化,从而提高不同患者不同病理特征和形成方式的分类精度。对冠状动脉粥样硬化斑块图像的识别实验验证了该方法的有效性和性能。
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引用次数: 0
A Study of Expert/Novice Perception in Arthroscopic Shoulder Surgery 关节镜肩关节手术中专家/新手感知的研究
Myat Su Yin, P. Haddawy, Benedikt W. Hosp, P. Sa-ngasoongsong, Thanwarat Tanprathumwong, Madereen Sayo, Supawit Yangyuenpradorn, A. Supratak
Arthroscopic shoulder surgery is an advanced orthopedic surgical procedure, which is particularly challenging due to the complex anatomy of the shoulder, and tight spaces for navigation, which also limits the view from the arthroscope. In carrying out arthroscopy, the ability to quickly and effectively navigate through the joint to reach a desired location is essential. Novices often experience confusion in trying to triangulate the information from arthroscopy output with the background knowledge of anatomy while orienting and navigating the instruments. In this paper, we report on the results of the first cadaveric eye-tracking study of arthroscopic surgery in which we investigate differences in perception between experts and novices. Novices' perception is analyzed with cognitive load analysis throughout the procedure and specifically, during the portions of the procedure in which subjects are observed to be confused. In investigating such portions, the gaze data analysis is supplemented with head rotations and acceleration information from gyroscope and accelerometer sensors from the eye tracker. We also use the gathered eye tracking metrics to construct a model to classify subjects into expert/novice. We find statistically significant relations between head movement as well as pupil diameter and periods of confusion. We identify a subset of the metrics that we use to build a simple classifier that is able to distinguish between novices and experts with accuracy of 84%.
关节镜肩部手术是一种先进的骨科手术,由于肩部复杂的解剖结构和狭窄的导航空间,这也限制了关节镜的视野,因此尤其具有挑战性。在进行关节镜检查时,快速有效地通过关节到达所需位置的能力是必不可少的。在定位和导航器械时,新手常常会在试图将关节镜输出的信息与解剖学背景知识进行三角测量时感到困惑。在这篇论文中,我们报告了第一个关节镜手术的尸体眼动追踪研究的结果,我们调查了专家和新手之间的感知差异。在整个过程中,特别是在观察到受试者感到困惑的过程中,用认知负荷分析来分析新手的感知。在调查这些部分时,凝视数据分析是由来自眼动仪的陀螺仪和加速度传感器的头部旋转和加速度信息补充的。我们还使用收集到的眼动追踪指标来构建一个模型,将受试者分为专家/新手。我们发现头部运动和瞳孔直径与困惑期之间有统计学意义的关系。我们确定了一个指标的子集,我们使用它来构建一个简单的分类器,能够区分新手和专家,准确率为84%。
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引用次数: 4
Hybrid Collaborative Model for Evidence-Based Healthcare Practice 基于证据的医疗保健实践的混合协作模型
M. Ekpenyong, S. Udoh, Mercy E. Edoho, Ifiok J. Udo, E. Udo, Temitope Fakiyesi, S. B. Oyong
Incorporating evidence-based healthcare practice would improve patients' response and safety and make patients partners in current healthcare practice. This partnership is certain to offer patients the opportunity to guide safety initiatives through data access by clinicians and encourage evidence-based healthcare while alleviating potential medical errors. In this paper, we promote a collaborative model that integrates interrelated concepts for responsive healthcare services that target patient-centred healthcare--with healthcare providers and relevant stakeholders in the loop. The implementation strategies for fulfilling the desired healthcare outcomes as well as design implications are also provided. The model is expected to offer transformative impact that would drive our weak healthcare system for improved healthcare and complement the huge dearth in healthcare services. The outcome is shared prosperity and health, and a mainstream of the people into healthcare decision making for informed policy planning and implementation.
纳入循证医疗保健实践将改善患者的反应和安全性,并使患者成为当前医疗保健实践的合作伙伴。这种伙伴关系肯定会为患者提供机会,通过临床医生访问数据来指导安全举措,并鼓励基于证据的医疗保健,同时减少潜在的医疗错误。在本文中,我们推广了一种协作模型,该模型集成了响应性医疗服务的相关概念,以患者为中心的医疗保健为目标——医疗保健提供者和相关利益相关者在循环中。还提供了实现预期医疗保健结果的实施策略以及设计含义。该模式有望带来变革性的影响,推动我们薄弱的医疗保健系统改善医疗保健,并弥补医疗保健服务的巨大不足。其结果是共享繁荣和健康,并将人们纳入医疗保健决策的主流,以便进行知情的政策规划和实施。
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引用次数: 1
Behavioural Understanding of Hospital Service Quality: Organisational Learning and Organisational Innovativeness 医院服务质量的行为理解:组织学习与组织创新
Thilageswary Arumugam, S. Arumugam
This study aims to identify the effect between organizational learning and service quality in public hospitals. The theoretical framework is derived based on Behavioral Theory of Firm by Cyert and March (1963) and Donabedian's Healthcare Quality Model. Service quality is discussed as endogenous construct. The Schwandt's organizational learning system model is evaluated as exogenous construct. The unit of analysis consists of clinical and clinical support departments with a sample size of 221 from 23 public hospitals in Peninsula Malaysia. Patients' perception on the departments' service quality is evaluated, and organizational learning and organizational innovativeness are assessed by the department heads in public hospitals. Patients' response data from 884 were aggregated to match the 221 responses of the department head. Structural equation modeling with AMOS and SPSS was applied to analyze data. Findings reveal that all hypotheses are supported. Organizational innovativeness shows a partial mediating effect between learning activity and service quality, and between performing actions and service quality. Service quality provides the organizational performance feedback to improve the learning activity for the human resource development. Thus, this study implies that the need for human resource development is imperative in contributing towards service performance to patients in the public hospitals.
本研究旨在探讨公立医院组织学习对服务品质的影响。理论框架是基于Cyert和March(1963)的企业行为理论和Donabedian的医疗质量模型推导出来的。将服务质量作为内生结构进行讨论。Schwandt的组织学习系统模型被评价为外生结构。分析单元由临床和临床支助部门组成,样本量为221人,来自马来西亚半岛23家公立医院。以公立医院科室主任为考核对象,评价患者对科室服务质量的感知,评价组织学习和组织创新能力。汇总884例患者的应答数据,与221例科室主任的应答相匹配。采用结构方程建模软件AMOS和SPSS对数据进行分析。研究结果表明,所有假设都得到了支持。组织创新在学习活动与服务质量、执行行为与服务质量之间存在部分中介作用。服务质量为人力资源开发提供组织绩效反馈以改善学习活动。因此,本研究表明,人力资源开发的需求是促进公立医院对患者的服务绩效的必要条件。
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引用次数: 0
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Proceedings of the 4th International Conference on Medical and Health Informatics
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