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Summarize the Etiology and Epidemiology Characteristics of the New Coronavirus 新型冠状病毒病原学及流行病学特点综述
S. Shen
Until May 16th, there are more than four million people who have been confirmed of the Covid-19 virus in the whole world and 311,739 of total deaths. The virus caused disastrous effects in the economy around the whole world, destroying small businesses and the stock market, ruining international transportation, devastating the morale of the people and prohibiting people from interacting and socializing. Considering these huge impacts that the virus made, on March, 12, 2020, the World Health Organization (WHO) characterized the Covid-19 caused by the Sars-CoV-2 virus as a global pandemic. There is not an effective vaccination or specific medicine to cure the disease. The most effective way to slow down the transmission is early detection, isolation of new carriers and operating proper treatment to patients. Thus, the research on the physical properties and clinical characteristics of the Covid-19 become significantly important. To prepare for the future prevention, this paper summarizes the overall treatment of the virus, mainly through the virus's origin, etiology, epidemiology, and clinical symptoms to inform readers more about the Covid-19, eliminate misunderstanding and bias to the virus, invoke the sense of self-protection and finally use scientific and logical methods to overcome this world-wide pandemic.
截至5月16日,全球有400多万人确诊感染Covid-19病毒,总死亡人数为311739人。这种病毒给全球经济造成了灾难性的影响,摧毁了小企业和股票市场,破坏了国际交通,破坏了人们的士气,禁止了人们的互动和社交。考虑到该病毒造成的这些巨大影响,2020年3月12日,世界卫生组织(世卫组织)将Sars-CoV-2病毒引起的Covid-19定性为全球大流行。目前还没有有效的疫苗或特效药来治愈这种疾病。减缓传播的最有效方法是早期发现、隔离新的携带者和对患者进行适当治疗。因此,研究新冠病毒的物理特性和临床特征变得尤为重要。本文主要从病毒的来源、病原学、流行病学、临床症状等方面对新冠肺炎的整体治疗进行了总结,让读者更多地了解新冠肺炎,消除对病毒的误解和偏见,唤起自我保护意识,最终用科学、合理的方法战胜这场全球性大流行,为今后的预防做好准备。
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引用次数: 0
Implementation of a Health Information System to Support the Screening and Surveillance of Suicidal Behaviours 实施健康信息系统以支持自杀行为的筛选和监测
J. Martínez-Miranda, Fernando López-Flores, Antonio Palacios-Isaac, Liliana Jiménez, Luis García Medina, Rosa M. Moreno-Robles, Giovanni Rosales
Suicidal behaviour is one of the leading causes of injury and death worldwide. In order to design and implement effective suicide's prevention strategies, it is important the timely identification of individuals at risk, as well as the systematic collection and analysis of suicide-related data. In this paper, we describe the main functionalities of a health information system developed to support general practitioners and mental health specialists with the screening of suicidal behaviours, the management of the follow-up process and the analysis and visualisation of the collected data for surveillance purposes. We also present the initial results obtained after the deployment of the system in six public health care institutions during the first eight months of use.
自杀行为是全世界造成伤害和死亡的主要原因之一。为了设计和实施有效的自杀预防策略,及时识别有自杀风险的个体以及系统地收集和分析自杀相关数据是很重要的。在本文中,我们描述了一个健康信息系统的主要功能,该系统旨在支持全科医生和心理健康专家筛选自杀行为,管理随访过程以及分析和可视化收集的监测数据。我们还介绍了在六个公共医疗机构部署该系统后,在使用的前八个月获得的初步结果。
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引用次数: 2
DeepFCA
Guoxuan Li
Biomedical ontologies contain target domain knowledge. In many cases, multiple ontologies are created independently for different purposes in the same biomedical domain. To fuse and extend existing knowledge, we need to find the corresponding entities (i.e. classes and properties) from different ontologies. Formal Concept Analysis (FCA) is a mature mathematical tool for biomedical ontology matching tasks and has achieved competitive performance. The FCA-based method mainly matches the ontologies through lexical tokens and structural information. This method ignores the inherent semantics of entities. On the other hand, representation learning techniques are widely used in different NLP tasks to capture the semantic similarity of words. In this paper, we propose a novel biomedical ontology matching method which we dub DeepFCA. We use pre-trained word vectors to initialize the vector representations onto which semantic information is inscribed. FCA embedding techniques are used to refine these vectors. DeepFCA combines FCA and word2vec methods to enhance the performance of biomedical ontology matching. To the best of our knowledge, this is the first attempt to apply FCA embedding techniques to biomedical ontology matching. Experiments on real-world biomedical ontologies show that DeepFCA improves the recall and F1-measure compared with the traditional FCA-based algorithm. It also achieves competitive performance compared with several state-of-the-art systems.
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引用次数: 9
Challenges of Assimilation of e-Health Systems in Healthcare: Insights into Activity Theory 医疗保健中电子卫生系统同化的挑战:对活动理论的见解
Patrick Shabaya, I. Ateya, G. Wanyembi
Healthcare organisations often adopt electronic health (e-Health) systems with the hope that they can improve the quality and reduce the cost of providing healthcare services. However, literature has shown mixed results concerning the benefits of e-Health systems for healthcare providers. In order for organisations to achieve the benefits of e-Health systems, they need to first adopt and assimilate these technologies into their work practices. Past studies have indicated limited assimilation of e-health systems and have associated it to the complex collaborative nature of clinical workflow processes. This paper presents challenges that inhibit the assimilation of e-Health systems in an emerging economy explored in terms of context and contradictions within the Activity Theory framework. The study explored four healthcare organisations in Nairobi city in Kenya. Results obtained indicated that assimilation is hindered by unresolved contradictions brought about by the interaction between different components in the clinical activity. In order for healthcare organisations to improve the assimilation and subsequent benefits of e-Health systems, they will need to identify and resolve these contradictions.
医疗机构通常采用电子医疗(e-Health)系统,希望能够提高医疗服务的质量,降低医疗服务的成本。然而,文献显示了关于电子健康系统对医疗保健提供者的好处的混合结果。为了让组织实现电子健康系统的好处,他们需要首先采用并吸收这些技术到他们的工作实践中。过去的研究表明,电子卫生系统的同化有限,并将其与临床工作流程的复杂协作性质联系起来。本文提出了在活动理论框架内的背景和矛盾方面探索的新兴经济体中抑制电子卫生系统同化的挑战。该研究调查了肯尼亚内罗毕市的四家医疗机构。所获得的结果表明,同化受到临床活动中不同成分之间相互作用所带来的未解决的矛盾的阻碍。为了让医疗机构更好地融入电子医疗系统并从中获益,他们需要识别并解决这些矛盾。
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引用次数: 0
An Evolutionary Analysis of Hospital Payment System Strategies Based on County Hospitals-Purchasers Game 基于县医院-购买者博弈的医院支付系统策略演化分析
Yufei Hu, Lianghua Chen
Providing rural residents with effective and affordable health services and financial protection against health risks are more or less problematic for developing countries with massive rural populations. The retrospective payment system (RPS) incurs excessive treatments, causes extreme waste of scarce medical resources and whether the payment system reform by converting to the prospective payment system (RPS) could achieve a desirable triple-win status. In this paper, a county hospital/rural medicare agency evolutionary game theoretical model in NW small-world network with EWA learning model and a corresponding computer model is formulated. We study the diffusion, conversion, and optimization of PPS and RPS, and hospitals' selection of treatments. The results show that PPS itself is a triple-win payment system that could eliminate excessive treatments, but cannot guide hospitals to choose the right intensity of treatments. The conversion from RPS to PPS relies on agencies' strict supervision, hospitals' expectation adjustment speed, and emphasis on future purchaser reimbursement. In order to optimize payment systems, the more hospitals emphasize patients' welfare, the more likely they are to provide appropriate treatments in intensity and moderation. It suggests a further need for developing countries to pursue various payment system reforms from PPS to RPS to pave the way for attaining mutual interests of three parties, especially providing appropriate treatments for rural residents.
对拥有大量农村人口的发展中国家来说,向农村居民提供有效和负担得起的保健服务以及防范健康风险的财务保护或多或少是个问题。回顾性支付制度导致过度治疗,对稀缺的医疗资源造成极大的浪费,向前瞻性支付制度转变的支付制度改革能否达到理想的三赢状态。本文利用EWA学习模型和相应的计算机模型,建立了NW小世界网络中县级医院/农村医疗机构的进化博弈理论模型。我们研究了PPS和RPS的扩散、转换和优化,以及医院对治疗方案的选择。结果表明,PPS本身是一种三赢支付制度,可以消除过度治疗,但不能指导医院选择合适的治疗强度。从RPS到PPS的转变依赖于机构的严格监管,医院的预期调整速度,以及对未来采购人员报销的重视。为了优化支付系统,医院越是强调病人的福利,他们就越有可能提供适当的治疗强度和适度。建议发展中国家进一步进行从PPS到RPS的各种支付制度改革,为实现三方的共同利益铺平道路,特别是为农村居民提供适当的治疗。
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引用次数: 0
Performance Evaluation of Convolutional Neural Network Architectures for Diagnosis of Childhood Pneumonia 卷积神经网络架构在儿童肺炎诊断中的性能评价
Christian Michael C. Qui, P. Abu
Pneumonia, a bacterial or viral infection of the lungs that causes the inflammation of the air sacs, is one of the leading causes of mortality of children in the world. Chest x-rays, one of the golden standard tools in determining pneumonia, is mainly used to detect malignancy in the lungs. However, the process of analyzing may be time-consuming for the radiologist, and costly to hospitals. Inter-observer variability with the diagnosis is very high since childhood pneumonia can be difficult to diagnose amongst radiologists. Considering that the design of convolutional neural networks makes it suited to process spatially distributed input such as images, the application of convolutional neural networks trained with chest X-rays to automate the diagnosis of pneumonia is viable. This study evaluates the performance of four well known architectures in literature using a childhood pneumonia dataset: (1) VGGNet, (2) ResNet, (3) DenseNet, and (4) AlexNet. Based on our simulations, VGGNet obtained the highest accuracy and sensitivity, followed by ResNet, which obtained the highest specificity, DenseNet, and AlexNet. Using gradient-weighted class activation to validate the learnt features, we observed that sufficiently deep architectures can effectively learn the features of pneumonia. In addition, the increase in depth improves the information flow at the cost of computational time, which is evident in DenseNet.
肺炎是一种肺部的细菌或病毒感染,导致肺泡发炎,是世界上儿童死亡的主要原因之一。胸部x光片是诊断肺炎的黄金标准工具之一,主要用于检测肺部的恶性肿瘤。然而,分析过程对放射科医生来说可能很耗时,对医院来说也很昂贵。由于儿童肺炎在放射科医师中很难诊断,因此观察者之间的诊断变异性非常高。考虑到卷积神经网络的设计使其适合处理空间分布的输入,如图像,使用胸片训练的卷积神经网络来自动诊断肺炎是可行的。本研究使用儿童肺炎数据集评估了文献中四个知名架构的性能:(1)VGGNet, (2) ResNet, (3) DenseNet和(4)AlexNet。基于我们的模拟,VGGNet获得最高的准确性和灵敏度,其次是ResNet,获得最高的特异性,DenseNet和AlexNet。使用梯度加权类激活来验证学习到的特征,我们观察到足够深的架构可以有效地学习肺炎的特征。此外,深度的增加以计算时间为代价改善了信息流,这在DenseNet中很明显。
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引用次数: 0
A Cloud Based Big Data Health-Analytics-as-a-Service Framework to Support Low Resource Setting Neonatal Intensive Care Unit 基于云的大数据健康分析即服务框架,支持低资源环境下的新生儿重症监护室
Meghana Bastwadkar, C. McGregor, S. Balaji
Critical care patients are monitored by a range of medical devices collecting high frequency data. New computing frameworks and platforms are being proposed to review and analyze the data in detail. The application of these approaches in a low resource setting is challenged by the approaches used for data acquisition. Software as a Service (SaaS) is a form of cloud computing where a cloud-based software application enables the storage, analysis and visualization of data within the cloud. A subset of SaaS is Health Analytics as a Service (HAaaS), which provides software to support health analytics in the cloud. The objective of this study is to design, implement, and demonstrate an extendable big-data compatible HAaaS framework that offers both real-time and retrospective analysis where data acquisition is not tightly coupled. A data warehousing framework is presented to facilitate analysis within a low resource setting. The framework has been instantiated in the Artemis platform within the context of the Belgaum Children Hospital (BCH) case study. Initial end-to-end testing with the Nellcor monitor (bedside monitor at BCH), which was not connected to any human, was completed. This testing confirms the functionality of the new Artemis cloud instance to receive data from test device using an alternate data acquisition approach.
重症监护病人由一系列医疗设备监测,这些设备收集高频数据。正在提出新的计算框架和平台来详细审查和分析数据。这些方法在低资源环境下的应用受到用于数据采集的方法的挑战。软件即服务(SaaS)是云计算的一种形式,其中基于云的软件应用程序可以在云中存储、分析和可视化数据。SaaS的一个子集是健康分析即服务(HAaaS),它提供支持云中的健康分析的软件。本研究的目的是设计、实现和演示一个可扩展的大数据兼容HAaaS框架,该框架提供实时和回顾性分析,其中数据获取不是紧密耦合的。提出了一个数据仓库框架,以方便在低资源设置下进行分析。在贝尔高姆儿童医院(BCH)案例研究的背景下,该框架已在Artemis平台上实例化。使用Nellcor监护仪(BCH的床边监护仪)完成了最初的端到端测试,该监护仪没有连接到任何人。该测试确认了新的Artemis云实例使用替代数据获取方法从测试设备接收数据的功能。
{"title":"A Cloud Based Big Data Health-Analytics-as-a-Service Framework to Support Low Resource Setting Neonatal Intensive Care Unit","authors":"Meghana Bastwadkar, C. McGregor, S. Balaji","doi":"10.1145/3418094.3418130","DOIUrl":"https://doi.org/10.1145/3418094.3418130","url":null,"abstract":"Critical care patients are monitored by a range of medical devices collecting high frequency data. New computing frameworks and platforms are being proposed to review and analyze the data in detail. The application of these approaches in a low resource setting is challenged by the approaches used for data acquisition. Software as a Service (SaaS) is a form of cloud computing where a cloud-based software application enables the storage, analysis and visualization of data within the cloud. A subset of SaaS is Health Analytics as a Service (HAaaS), which provides software to support health analytics in the cloud. The objective of this study is to design, implement, and demonstrate an extendable big-data compatible HAaaS framework that offers both real-time and retrospective analysis where data acquisition is not tightly coupled. A data warehousing framework is presented to facilitate analysis within a low resource setting. The framework has been instantiated in the Artemis platform within the context of the Belgaum Children Hospital (BCH) case study. Initial end-to-end testing with the Nellcor monitor (bedside monitor at BCH), which was not connected to any human, was completed. This testing confirms the functionality of the new Artemis cloud instance to receive data from test device using an alternate data acquisition approach.","PeriodicalId":192804,"journal":{"name":"Proceedings of the 4th International Conference on Medical and Health Informatics","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115072700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Covid-19 Chest Radiography Images Analysis Based on Integration of Image Preprocess, Guided Grad-CAM, Machine Learning and Risk Management 基于图像预处理、Guided Grad-CAM、机器学习和风险管理集成的Covid-19胸片图像分析
Tsung-Chieh Lin, Hsi-Chieh Lee
COVID19 coronavirus has widely infected more than 10 million people and killed more than 500,000 globally till July 1, 2020. In this paper, we describe a potential methodology, integration of image preprocess, Guided Grad-CAM, machine learning and risk management based on chest radiography images, as one of workable alarm and analysis systems to support clinicians against COVID-19 outbreak threat. We leverage pre-trained CNN models as backbone with further transfer learning to analyze public open datasets composed of 5851 chest radiography images for 4 classes classification, and 15478 images from COVIDx dataset for 3 classes classification, facilitated with steps of ROI and mask, and CNN layer visualization of guided grad-CAM to help CNN focused on critical infection focus in qualitative perspective. In quantitative perspective of 4 classes classification result, accuracy, average sensitivity, average precision, and COVID19 sensitivity of single ResNet50 and our second bagging ensemble model are (77.2%/78.8%/81.9%/100%) and (81.5%/81.4%,86.8%/100%) respectively. Ensemble way of several CNNs and other machine learning methods used here is to contribute about 4% accuracy improvement on top of best single CNN (ResNet50). In our 3 classes classification, those metrics of ensemble model and benchmark are (93.1%/90.1%/89.7%/83%) and (90%/85.9%, 82.4%/77%). We conclude ensemble approach would facilitate weaker classifier more. Beside to accuracy-oriented analysis, a cost minimization approach is suggested here to provide clinicians options of different risk consideration flexibility by trade off among different categories and performance rates.
截至2020年7月1日,covid - 19冠状病毒已在全球范围内广泛感染了1000多万人,造成50多万人死亡。在本文中,我们描述了一种潜在的方法,将图像预处理、Guided Grad-CAM、机器学习和基于胸部x线图像的风险管理集成为一种可行的报警和分析系统,以支持临床医生应对COVID-19爆发威胁。我们以预训练的CNN模型为骨干,通过进一步的迁移学习,对5851张胸片图像组成的公共开放数据集进行4类分类,对来自covid数据集的15478张图像进行3类分类,并借助ROI和mask的步骤,以及引导的grad-CAM的CNN层可视化,帮助CNN从定性的角度关注关键感染焦点。从4类分类结果的定量角度来看,单个ResNet50和我们的第二bagging集成模型的准确率、平均灵敏度、平均精度和COVID19灵敏度分别为(77.2%/78.8%/81.9%/100%)和(81.5%/81.4%、86.8%/100%)。本文使用的几种CNN和其他机器学习方法的集成方法在最佳单一CNN (ResNet50)的基础上贡献了约4%的准确率提高。在我们的3类分类中,集合模型和基准的度量分别为(93.1%/90.1%/89.7%/83%)和(90%/85.9%,82.4%/77%)。我们得出结论,集成方法更有利于弱分类器。除了以准确性为导向的分析外,本文还建议采用成本最小化的方法,通过在不同类别和绩效率之间进行权衡,为临床医生提供不同风险考虑灵活性的选择。
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引用次数: 16
A Cryptanalysis of Trustworthy Electronicvoting using Adjusted Blockchain Technology 基于调整后区块链技术的可信电子投票密码分析
Ming-Te Chen, C. Chen, Tsung-Hung Lin
The voting process and results and the trust of voters are very important issues in current modern society. When voters could trust that the voting results are valid, people are willing to trust this voter will serve for them dealing with issues such as national security, education, and economics in the future. Electronic voting is an efficient method that could help people who could not vote in a limited period. Besides, it also solves the problem of long voting time due to many voters or more complicated voting steps. Although the voting machine could perform a record of votes and voting calculations, it does not require humans to handle a lot of above voting works. Nowadays, electronic voting has become an important research. However, there are too many assumptions and institutions which are often added in this research area. It might become to be unpractical when this voting research is applied to real society. Hence, we thought that blockchain might be a good solution for electronic voting research. Nevertheless, how to apply blockchain to protect people's privacy, anonymity, and voting rights still needs to be discussed in current days. In this paper, we proposed cryptanalysis on a trustworthy electronic voting scheme with blockchain and find out that there are some problems in their proposed scheme.
投票过程和结果以及选民的信任是当今现代社会非常重要的问题。当选民们相信投票结果是有效的时候,人们就会愿意相信这个选民将来会在国家安全、教育、经济等问题上为他们服务。电子投票是一种有效的方法,可以帮助那些在有限的时间内无法投票的人。此外,它还解决了由于选民多或投票步骤复杂而导致投票时间长的问题。虽然投票机可以执行投票记录和投票计算,但它不需要人类处理大量以上投票工作。如今,电子投票已成为一个重要的研究课题。然而,在这一研究领域中经常添加太多的假设和制度。当这种投票研究应用于现实社会时,可能会变得不切实际。因此,我们认为区块链可能是电子投票研究的一个很好的解决方案。然而,如何应用区块链来保护人们的隐私、匿名性和投票权,目前仍需要讨论。本文对一种基于区块链的可信电子投票方案进行了密码分析,并发现该方案存在一些问题。
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引用次数: 3
A Study of Individual Human Mobility Patterns Related to Malaria Transmission Along the Thai-Myanmar Border 与泰缅边境疟疾传播相关的个体人类流动模式研究
Chaitawat Sa-ngamuang, P. Haddawy, S. Lawpoolsri, T. Barkowsky, Patiwat Sa-angchai
Malaria elimination remains a major challenge worldwide largely because human mobility can result in importing cases from areas of high incidence to areas of low incidence. Thus, understanding the role of human mobility in malaria transmission is essential. In this study, we collect mobility data from 88 participants over ten months using a smartphone application. Our study area is in northern Thailand along the border with Myanmar, from which malaria may be imported. We analyze amount of time spent in Thailand/Myanmar in areas of various land cover types, spatial distribution of movement, and network patterns of movement. We find significant differences between villages in amounts of time spent in forest areas and in Myanmar, with most travel to Myanmar occurring from two villages. We find significantly higher spatial distribution of movement in the dry season than the wet season. Our results provide important insight to help target surveillance and intervention.
消除疟疾仍然是世界范围内的一项重大挑战,主要是因为人员流动可能导致病例从高发地区传入低发地区。因此,了解人类流动在疟疾传播中的作用至关重要。在这项研究中,我们收集了88名参与者在10个月内使用智能手机应用程序的移动数据。我们的研究区域位于泰国北部与缅甸接壤的边境,疟疾可能从那里输入。我们分析了在泰国/缅甸不同土地覆盖类型的地区花费的时间,运动的空间分布和运动的网络模式。我们发现,在森林地区和缅甸度过的时间在村庄之间存在显著差异,大多数前往缅甸的旅行都发生在两个村庄。我们发现旱季运动的空间分布明显高于雨季。我们的研究结果为帮助有针对性的监测和干预提供了重要的见解。
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引用次数: 1
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Proceedings of the 4th International Conference on Medical and Health Informatics
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