Pub Date : 2022-04-01DOI: 10.17712/nsj.2022.2.20210145
H. Jamjoom, Abdulhadi Y. Gahtani, A. Jamjoom
Objectives: To identify the predictors of citation rates for research publication in Neurosciences. Methods: All original articles including meta-analyses (MAs) and systematic reviews (SRs) that were published in Neurosciences during 2011 to 2019 were reviewed. The impact of several predictors on citation rates was assessed using correlation coefficient and mean difference tests. Results: This study examined 231 articles. The mean article citation number was 11.6. The correlation analysis showed a significant association between citation rates and duration from publication in years (p<0.0001), sample size (p<0.0001), study design (p=0.0353), and level of evidence (LOE) (p=0.03). The comparative analysis showed significantly more citations for articles that were published 6-10 years ago (p<0.0001), had a sample size >91 (p=0.0359), were randomized controlled trials (p=0.0353), MAs and SRs (p<0.0001), and level of evidence (LOE)-I (p=0.0004). Retrospective case series had significantly lower citations. The higher and lower citation numbers for publications from Iran and rehabilitation, respectively, may have been influenced by the duration from publication. Conclusion: The most significant predictors of citation rates for Neurosciences publications were the age of articles, population size, study design, and LOE. Awareness of the predictors of citation rates may help researchers enhance the academic impact of their work.
{"title":"Predictors of citation rates for research publications in Neurosciences","authors":"H. Jamjoom, Abdulhadi Y. Gahtani, A. Jamjoom","doi":"10.17712/nsj.2022.2.20210145","DOIUrl":"https://doi.org/10.17712/nsj.2022.2.20210145","url":null,"abstract":"Objectives: To identify the predictors of citation rates for research publication in Neurosciences. Methods: All original articles including meta-analyses (MAs) and systematic reviews (SRs) that were published in Neurosciences during 2011 to 2019 were reviewed. The impact of several predictors on citation rates was assessed using correlation coefficient and mean difference tests. Results: This study examined 231 articles. The mean article citation number was 11.6. The correlation analysis showed a significant association between citation rates and duration from publication in years (p<0.0001), sample size (p<0.0001), study design (p=0.0353), and level of evidence (LOE) (p=0.03). The comparative analysis showed significantly more citations for articles that were published 6-10 years ago (p<0.0001), had a sample size >91 (p=0.0359), were randomized controlled trials (p=0.0353), MAs and SRs (p<0.0001), and level of evidence (LOE)-I (p=0.0004). Retrospective case series had significantly lower citations. The higher and lower citation numbers for publications from Iran and rehabilitation, respectively, may have been influenced by the duration from publication. Conclusion: The most significant predictors of citation rates for Neurosciences publications were the age of articles, population size, study design, and LOE. Awareness of the predictors of citation rates may help researchers enhance the academic impact of their work.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"27 1","pages":"116 - 120"},"PeriodicalIF":0.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45805209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.17712/nsj.2022.2.20210121
Osama Al-Wutayd, A. Mohamed, J. Saeedi, Hessa S. Alotaibi, M. A. Al Jumah
Objectives: To determine whether body size in different age periods is associated with an increased risk of MS in Saudi Arabia. Methods: This study included 307 MS patients and 307 healthy controls from clinics and hospital wards in three cities (Riyadh, Jeddah, and Dammam) in Saudi Arabia (2016-2017). We used Stunkard’s standard body silhouettes to determine the participants’ body sizes (from 1 to 9) during different age periods (school levels). We calculated adjusted odds ratios (AORs) and 95% confidence intervals (CIs) and performed multivariable analysis adjusted for age and gender. Results: Large body sizes (silhouettes 6–9) and body size 5 during intermediate school were associated with an increased risk of MS (AOR: 3.75, 95% CI: 1.10–12.78 and AOR: 3.75, 95% CI: 1.41–10, respectively). The smallest body size (1) during intermediate school was associated with a lower risk of MS (AOR: 0.39, 95% CI: 0.17–0.90) compared to body size 3. Conclusion: Overweight and obesity during the intermediate school period (ages 13–15 years) are associated with an increased risk of MS, particularly among females.
{"title":"Association between obesity during different age periods and multiple sclerosis in Saudi Arabia: A multicenter case–control study","authors":"Osama Al-Wutayd, A. Mohamed, J. Saeedi, Hessa S. Alotaibi, M. A. Al Jumah","doi":"10.17712/nsj.2022.2.20210121","DOIUrl":"https://doi.org/10.17712/nsj.2022.2.20210121","url":null,"abstract":"Objectives: To determine whether body size in different age periods is associated with an increased risk of MS in Saudi Arabia. Methods: This study included 307 MS patients and 307 healthy controls from clinics and hospital wards in three cities (Riyadh, Jeddah, and Dammam) in Saudi Arabia (2016-2017). We used Stunkard’s standard body silhouettes to determine the participants’ body sizes (from 1 to 9) during different age periods (school levels). We calculated adjusted odds ratios (AORs) and 95% confidence intervals (CIs) and performed multivariable analysis adjusted for age and gender. Results: Large body sizes (silhouettes 6–9) and body size 5 during intermediate school were associated with an increased risk of MS (AOR: 3.75, 95% CI: 1.10–12.78 and AOR: 3.75, 95% CI: 1.41–10, respectively). The smallest body size (1) during intermediate school was associated with a lower risk of MS (AOR: 0.39, 95% CI: 0.17–0.90) compared to body size 3. Conclusion: Overweight and obesity during the intermediate school period (ages 13–15 years) are associated with an increased risk of MS, particularly among females.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"27 1","pages":"87 - 93"},"PeriodicalIF":0.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47110458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.17712/nsj.2022.2.20210101
Norah A Alharbi, S. Alawi, Yousef M Alharbi, Muath Y. Alharbi, Tareq Alsamarh, A. Aldubaiyan, Saleh Alwasil, Abdulrahman A Alomairi
Objectives: To determine the prevalence of depression and anxiety in adult multiple sclerosis patients attending tertiary facilities in Riyadh, Saudi Arabia. Methods: This is a cross-sectional study conducted among MS patients in Riyadh City, Saudi Arabia. A self-administered questionnaire was distributed among MS patients at Prince Sultan Military Medical City in Riyadh, Saudi Arabia between April 2020 and January 2021. The questionnaire consisted of socio-demographic characteristics and the Hospital Anxiety and Depression Scale (HADS). Univariate using Chi-square test and multivariate regression analysis had been performed to determine the factors associated with anxiety and depression among MS patients. Results: A total of 328 MS patients took part in the study. The most prevalent age group was 36–45 years old (38.4%), with over 70% of the participants being females. Anxiety and depression were shown to be prevalent in MS patients at 42.9 percent and 58.8 percent, respectively. According to statistical tests, being less educated and having partial to severe disability was linked to an increased rate of anxiety and depression, whereas being female was more prone to anxiety symptoms but not depression. Conclusion: Depression was more frequent than anxiety. As a result, while assessing psychiatric diseases in the study group, depression/anxiety may be expected to be more frequent amongst those of greater disability.
{"title":"Prevalence of depression and anxiety among adult patients with multiple sclerosis at Riyadh City, Saudi Arabia","authors":"Norah A Alharbi, S. Alawi, Yousef M Alharbi, Muath Y. Alharbi, Tareq Alsamarh, A. Aldubaiyan, Saleh Alwasil, Abdulrahman A Alomairi","doi":"10.17712/nsj.2022.2.20210101","DOIUrl":"https://doi.org/10.17712/nsj.2022.2.20210101","url":null,"abstract":"Objectives: To determine the prevalence of depression and anxiety in adult multiple sclerosis patients attending tertiary facilities in Riyadh, Saudi Arabia. Methods: This is a cross-sectional study conducted among MS patients in Riyadh City, Saudi Arabia. A self-administered questionnaire was distributed among MS patients at Prince Sultan Military Medical City in Riyadh, Saudi Arabia between April 2020 and January 2021. The questionnaire consisted of socio-demographic characteristics and the Hospital Anxiety and Depression Scale (HADS). Univariate using Chi-square test and multivariate regression analysis had been performed to determine the factors associated with anxiety and depression among MS patients. Results: A total of 328 MS patients took part in the study. The most prevalent age group was 36–45 years old (38.4%), with over 70% of the participants being females. Anxiety and depression were shown to be prevalent in MS patients at 42.9 percent and 58.8 percent, respectively. According to statistical tests, being less educated and having partial to severe disability was linked to an increased rate of anxiety and depression, whereas being female was more prone to anxiety symptoms but not depression. Conclusion: Depression was more frequent than anxiety. As a result, while assessing psychiatric diseases in the study group, depression/anxiety may be expected to be more frequent amongst those of greater disability.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"27 1","pages":"71 - 78"},"PeriodicalIF":0.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49511565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.17712/nsj.2022.2.20210142
Amani S Almwled, Abdulkarim O. Almuhaydili, S. M. Altamimi, Muhannad A Alzahrani, Rodhan K Alnahdi, Saad B Almotairi, Bandar N. Aljafen, F. Alosaimi
Objectives: To identify the magnitude of treatment adherence among people with epilepsy (PWE) and the impact of sociodemographic, medical and psychosocial factors on treatment adherence. Methods: A quantitative cross-sectional observational study was performed based on data collected from adult patients attending the epilepsy clinic, King Saud University Medical City, Riyadh, Saudi Arabia. Patients completed paper-based questionnaires including a sociodemographic, cultural, psychiatric history and medical history sections. In addition to that we evaluated treatment adherence by visual-analogue scale (VAS), depressive symptoms by PHQ-9, anxiety symptoms by GAD7, physical symptoms by PHQ-15, attachment style by ECR16 and cognitive impairment by MOCA. Results: A total of 207 patients participated, with a mean age of 34 years;.53.6% were female. The mean patient-reported adherence to their treatment regimen was 81.6%±18.4%. Univariate analysis revealed statistically significant negative associations between depression, anxiety and physical symptoms and treatment adherence. However, multiple linear regression analysis only showed physical symptoms to be a significant predictor for epilepsy medication adherence. Conclusion: Somatic (physical) complaints could be important predictors of treatment adherence in (PWE). This study is one of the first to suggest the importance of targeting physical symptoms in screening and intervention approaches to improve Antiepileptic drugs (AEDs) adherence.
{"title":"Prevalence and biopsychosocial factors associated with treatment adherence among people with epilepsy in a tertiary care hospital in Riyadh, Saudi Arabia","authors":"Amani S Almwled, Abdulkarim O. Almuhaydili, S. M. Altamimi, Muhannad A Alzahrani, Rodhan K Alnahdi, Saad B Almotairi, Bandar N. Aljafen, F. Alosaimi","doi":"10.17712/nsj.2022.2.20210142","DOIUrl":"https://doi.org/10.17712/nsj.2022.2.20210142","url":null,"abstract":"Objectives: To identify the magnitude of treatment adherence among people with epilepsy (PWE) and the impact of sociodemographic, medical and psychosocial factors on treatment adherence. Methods: A quantitative cross-sectional observational study was performed based on data collected from adult patients attending the epilepsy clinic, King Saud University Medical City, Riyadh, Saudi Arabia. Patients completed paper-based questionnaires including a sociodemographic, cultural, psychiatric history and medical history sections. In addition to that we evaluated treatment adherence by visual-analogue scale (VAS), depressive symptoms by PHQ-9, anxiety symptoms by GAD7, physical symptoms by PHQ-15, attachment style by ECR16 and cognitive impairment by MOCA. Results: A total of 207 patients participated, with a mean age of 34 years;.53.6% were female. The mean patient-reported adherence to their treatment regimen was 81.6%±18.4%. Univariate analysis revealed statistically significant negative associations between depression, anxiety and physical symptoms and treatment adherence. However, multiple linear regression analysis only showed physical symptoms to be a significant predictor for epilepsy medication adherence. Conclusion: Somatic (physical) complaints could be important predictors of treatment adherence in (PWE). This study is one of the first to suggest the importance of targeting physical symptoms in screening and intervention approaches to improve Antiepileptic drugs (AEDs) adherence.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"27 1","pages":"94 - 103"},"PeriodicalIF":0.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46548591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.17712/nsj.2022.2.20210123
Huan Zhao, Min Shi, Fang Yang, Xuhong Yang
Kearns-Sayre Syndrome (KSS) is a subtype of chronic progressive external ophthalmoplegia (CPEO). In this case, A 21-year-old man diagnosed with KSS, and presented with chronic progressive blepharoptosis (ptosis) and external ophthalmoplegia, diffuse depigmentation of the retinal pigment epithelium, and cerebellar ataxia, with a cerebrospinal fluid protein of 254 mg/dL, was reported. Genetic screening revealed a novel mutated gene in SLC25A4 in the patient as well as in his mother: NM_001151:c.170G>C in exon 2. Its imaging finding is a characteristic progressive atrophy of the right cerebellar hemisphere. In conclusion, we found a case of KSS with a novel mutated gene in SLC25A4: NM_001151:c.170G>C in exon 2 as the pathogenic mechanism, and found that KSS can be caused only when the proportion of mutations in the SLC25A4 gene reach a certain degree, and the patient with KSS showed a unique cranial imaging feature of unilateral progressive cerebellar atrophy.
{"title":"Kearns-Sayre syndrome with rare imaging finding of SLC25A4 Mutation","authors":"Huan Zhao, Min Shi, Fang Yang, Xuhong Yang","doi":"10.17712/nsj.2022.2.20210123","DOIUrl":"https://doi.org/10.17712/nsj.2022.2.20210123","url":null,"abstract":"Kearns-Sayre Syndrome (KSS) is a subtype of chronic progressive external ophthalmoplegia (CPEO). In this case, A 21-year-old man diagnosed with KSS, and presented with chronic progressive blepharoptosis (ptosis) and external ophthalmoplegia, diffuse depigmentation of the retinal pigment epithelium, and cerebellar ataxia, with a cerebrospinal fluid protein of 254 mg/dL, was reported. Genetic screening revealed a novel mutated gene in SLC25A4 in the patient as well as in his mother: NM_001151:c.170G>C in exon 2. Its imaging finding is a characteristic progressive atrophy of the right cerebellar hemisphere. In conclusion, we found a case of KSS with a novel mutated gene in SLC25A4: NM_001151:c.170G>C in exon 2 as the pathogenic mechanism, and found that KSS can be caused only when the proportion of mutations in the SLC25A4 gene reach a certain degree, and the patient with KSS showed a unique cranial imaging feature of unilateral progressive cerebellar atrophy.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"27 1","pages":"111 - 115"},"PeriodicalIF":0.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44859939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.17712/nsj.2022.2.20210122
Yassir M. Almatrafi, Mohammed A. Babakkor, Muhammed Irfan, Ebaa T Samkari, Waleed M. Alzahrani, Doaa K. Mohorjy, Sarmad Zahoor, M. T. Farooq, H. M. Sajid Jehangir
Objectives: To assess the efficacy and safety of rituximab for multiple sclerosis (MS) treatment in terms of reduction in clinical relapses, magnetic resonance imaging (MRI) activity, Expanded Disability Status Scale (EDSS) score and adverse events. Methods: This is a retrospective cross-sectional study conducted at King Abdullah Medical City, from January 2017 to August 2021, involving patients with MS given rituximab, with 1-year follow-up. Clinical parameters were noted pre- and post-treatment to determine efficacy; adverse events were noted to analyze safety. A paired samples t-test was used to compare responses pre- and post-treatment. A p-value<0.05 was considered significant. Results: Among 31 patients, 6 (19.4%) had progressive MS, and 25 (80.6%) had relapsing-remitting MS (mean disease duration=8.12±5.65 years). The annual relapse rate reduced from 1.67±0.97 to 0.06±0.25 (p<0.001), the EDSS score from 3.16±2.14 to 2.80±2.28 (p=0.141) and the MRI activity score from 1.84±1.03 to 1.03±0.18 (p<0.001). Only one patient had enhancing lesion activity post-treatment. The commonest side effect was urinary tract infection (25.8%). Only 2 patients discontinued the drug. Conclusion: Rituximab is an efficient drug in reducing the annual relapse rate and MRI activity of patients with MS, with few tolerable side effects not leading to drug discontinuation or any lethal outcome.
{"title":"Efficacy and safety of rituximab in patients with multiple sclerosis","authors":"Yassir M. Almatrafi, Mohammed A. Babakkor, Muhammed Irfan, Ebaa T Samkari, Waleed M. Alzahrani, Doaa K. Mohorjy, Sarmad Zahoor, M. T. Farooq, H. M. Sajid Jehangir","doi":"10.17712/nsj.2022.2.20210122","DOIUrl":"https://doi.org/10.17712/nsj.2022.2.20210122","url":null,"abstract":"Objectives: To assess the efficacy and safety of rituximab for multiple sclerosis (MS) treatment in terms of reduction in clinical relapses, magnetic resonance imaging (MRI) activity, Expanded Disability Status Scale (EDSS) score and adverse events. Methods: This is a retrospective cross-sectional study conducted at King Abdullah Medical City, from January 2017 to August 2021, involving patients with MS given rituximab, with 1-year follow-up. Clinical parameters were noted pre- and post-treatment to determine efficacy; adverse events were noted to analyze safety. A paired samples t-test was used to compare responses pre- and post-treatment. A p-value<0.05 was considered significant. Results: Among 31 patients, 6 (19.4%) had progressive MS, and 25 (80.6%) had relapsing-remitting MS (mean disease duration=8.12±5.65 years). The annual relapse rate reduced from 1.67±0.97 to 0.06±0.25 (p<0.001), the EDSS score from 3.16±2.14 to 2.80±2.28 (p=0.141) and the MRI activity score from 1.84±1.03 to 1.03±0.18 (p<0.001). Only one patient had enhancing lesion activity post-treatment. The commonest side effect was urinary tract infection (25.8%). Only 2 patients discontinued the drug. Conclusion: Rituximab is an efficient drug in reducing the annual relapse rate and MRI activity of patients with MS, with few tolerable side effects not leading to drug discontinuation or any lethal outcome.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"27 1","pages":"65 - 70"},"PeriodicalIF":0.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42897901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.17712/nsj.2022.2.20210135
Ghalib M. Alanazi, Turki F. AlOsaimi, A. Alwadei, Ali Al-Otaibi, Lamya A. Jad, A. Al-Attas
Objectives: To compare the efficacy and safety of corpus callosotomy versus vagus nerve stimulation (VNS) as long-term adjunctive therapies in children with Lennox–Gastaut syndrome. Methods: This retrospective study was conducted in King Fahad Medical City between 2010 and 2019. The authors identified and followed 9 patients with Lennox–Gastaut syndrome (LGS) who underwent corpus callosotomy or VNS implantation for at least 12 months; seizure frequency and major complications were monitored. Five patients with a mean age of 10.8±1.3 years had corpus callosotomy, and 4 patients with a mean age of 13.8±3.9 years were implanted with VNS stimulators. Results: Reduction in seizure frequency was achieved in all 5 patients who underwent corpus callosotomy, with greater than 75% seizure reduction in more than 50% in one, and greater than 25% in 2 respectively. However, in those implanted with VNS, 2 (50%) patients achieved a reduction in seizure frequency of greater than 75% and 2 (50%) greater than 25%, respectively. No significant difference was observed between the 2 treatment groups. One patient who underwent corpus callosotomy suffered cerebrospinal fluid leakage, and swallowing difficulties in one patient who underwent VNS. Conclusion: Both corpus callosotomy and VNS are safe and effective as adjunctive treatments for LGS patients.
{"title":"Efficacy and safety of corpus callosotomy versus vagus nerve stimulation as long-term adjunctive therapies in children with Lennox–Gastaut syndrome","authors":"Ghalib M. Alanazi, Turki F. AlOsaimi, A. Alwadei, Ali Al-Otaibi, Lamya A. Jad, A. Al-Attas","doi":"10.17712/nsj.2022.2.20210135","DOIUrl":"https://doi.org/10.17712/nsj.2022.2.20210135","url":null,"abstract":"Objectives: To compare the efficacy and safety of corpus callosotomy versus vagus nerve stimulation (VNS) as long-term adjunctive therapies in children with Lennox–Gastaut syndrome. Methods: This retrospective study was conducted in King Fahad Medical City between 2010 and 2019. The authors identified and followed 9 patients with Lennox–Gastaut syndrome (LGS) who underwent corpus callosotomy or VNS implantation for at least 12 months; seizure frequency and major complications were monitored. Five patients with a mean age of 10.8±1.3 years had corpus callosotomy, and 4 patients with a mean age of 13.8±3.9 years were implanted with VNS stimulators. Results: Reduction in seizure frequency was achieved in all 5 patients who underwent corpus callosotomy, with greater than 75% seizure reduction in more than 50% in one, and greater than 25% in 2 respectively. However, in those implanted with VNS, 2 (50%) patients achieved a reduction in seizure frequency of greater than 75% and 2 (50%) greater than 25%, respectively. No significant difference was observed between the 2 treatment groups. One patient who underwent corpus callosotomy suffered cerebrospinal fluid leakage, and swallowing difficulties in one patient who underwent VNS. Conclusion: Both corpus callosotomy and VNS are safe and effective as adjunctive treatments for LGS patients.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"27 1","pages":"59 - 64"},"PeriodicalIF":0.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48064589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.17712/nsj.2022.2.20210144
Fatimah Alsaad, Norah Alkeneetir, M. Almatroudi, Alhanouf Alatawi, Abeer Alotaibi, O. Aldibasi, I. Khatri
Objectives: To determine the frequency, risk factors, and outcomes of Early seizure (ES) after stroke in a Saudi cohort. Methods: A retrospective study was conducted in King Abdulaziz Medical City, Riyadh, KSA. All stroke patients whether they had first or recurrent stroke were included from February 2016 to December 2017. Data were analyzed using the SAS software version 9.4. Results: Out of 665 patients, 456 (68.6%) were males and 564 (85.2%) were Saudis; the cohort’s mean age was 60.6±12.6 years. Fifty-one (7.7%) patients had ES, which were more common in women (p=0.0123). Loss of consciousness (p=0.0402) and confusion (<0.0007) were associated with ES, whereas unilateral weakness (p=0.001) and unilateral numbness (p=0.0317) at presentation decreased the risk of ES. Vascular risk factors did not differ between patients with and without ES. Hemorrhagic stroke was associated with ES (p=0.0054), whereas patients with small vessel disease were less likely to develop ES (p=0.0013). Patients with ES had more severe stroke (NIHSS >5) (p=0.0139), more ICU admissions (49% vs. 26.2%; p=0.0005), longer length of hospital stay (44.9 days vs. 24.9 days; p=0.0018), higher rates of stroke-related complications (e.g. recurrent stroke, pulmonary embolism, hospital acquired infections, and need for tracheostomy and gastrostomy tube placement) (p≤0.0001), and were likely to be more severely disabled defined as mRS 3–5 at discharge (47.7% vs. 40.8%; p=0.0055) or to die in hospital (11.8% vs. 4.6%; p≤0.0001). Conclusion: The ES after stroke were common in our cohort. Increased stroke severity and confusion were independent predictors of ES. The ES were associated with higher rates of in-hospital complications, longer length of hospital stay, and worse outcomes at discharge.
{"title":"Early seizures in stroke – frequency, risk factors, and effect on patient outcomes in a tertiary center in Saudi Arabia","authors":"Fatimah Alsaad, Norah Alkeneetir, M. Almatroudi, Alhanouf Alatawi, Abeer Alotaibi, O. Aldibasi, I. Khatri","doi":"10.17712/nsj.2022.2.20210144","DOIUrl":"https://doi.org/10.17712/nsj.2022.2.20210144","url":null,"abstract":"Objectives: To determine the frequency, risk factors, and outcomes of Early seizure (ES) after stroke in a Saudi cohort. Methods: A retrospective study was conducted in King Abdulaziz Medical City, Riyadh, KSA. All stroke patients whether they had first or recurrent stroke were included from February 2016 to December 2017. Data were analyzed using the SAS software version 9.4. Results: Out of 665 patients, 456 (68.6%) were males and 564 (85.2%) were Saudis; the cohort’s mean age was 60.6±12.6 years. Fifty-one (7.7%) patients had ES, which were more common in women (p=0.0123). Loss of consciousness (p=0.0402) and confusion (<0.0007) were associated with ES, whereas unilateral weakness (p=0.001) and unilateral numbness (p=0.0317) at presentation decreased the risk of ES. Vascular risk factors did not differ between patients with and without ES. Hemorrhagic stroke was associated with ES (p=0.0054), whereas patients with small vessel disease were less likely to develop ES (p=0.0013). Patients with ES had more severe stroke (NIHSS >5) (p=0.0139), more ICU admissions (49% vs. 26.2%; p=0.0005), longer length of hospital stay (44.9 days vs. 24.9 days; p=0.0018), higher rates of stroke-related complications (e.g. recurrent stroke, pulmonary embolism, hospital acquired infections, and need for tracheostomy and gastrostomy tube placement) (p≤0.0001), and were likely to be more severely disabled defined as mRS 3–5 at discharge (47.7% vs. 40.8%; p=0.0055) or to die in hospital (11.8% vs. 4.6%; p≤0.0001). Conclusion: The ES after stroke were common in our cohort. Increased stroke severity and confusion were independent predictors of ES. The ES were associated with higher rates of in-hospital complications, longer length of hospital stay, and worse outcomes at discharge.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"27 1","pages":"104 - 110"},"PeriodicalIF":0.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47555843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.17712/nsj.2020.2.20200061
H. Al-Jehani
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{"title":"Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle","authors":"","doi":"10.32388/roxo03","DOIUrl":"https://doi.org/10.32388/roxo03","url":null,"abstract":"","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"1 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69639648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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