Pub Date : 2023-10-01DOI: 10.17712/nsj.2023.4.20230030
Muhannad A Asiri, Mohammed S Alqahtani, Saeed A Alqahtani, Mohammed M Alwadai, Naif F Alharbi, Mohammed O Aqeeli, Saeed S Alzahrani
Objectives: To investigate the prevalence and risk factors linked to contrast-induced nephropathy in this specific patient population, aiming to ensure the highest quality of clinical care.
Methods: In a retrospective analysis, all patients who presented with an acute stroke to King Fahad Hospital, Jeddah, Emergency Department from March until November 2022 and underwent Computed Tomography Angiography (CTA) brain, Inclusion criteria were as follows: a baseline creatinine results and CTA examination performed within 24 hours of symptom onset and an available early (<5 days after CTA) follow-up creatinine result.
Results: Among 246 stroke patients in the emergency, 182 underwent brain CTA and 8.24% had Contrast-Induced Nephropathy (CIN). intracerebral hemorrhage (ICH) increased CIN risk 7-fold (OR=6.7; 95% CI: 1.23-33.3). Abnormal baseline raised CIN risk 8-fold (OR=7.8; 95% CI: 1.74-35.1). hypertension doubled the risk for CIN (OR=2.1; 95% CI: 1.26-6.98) CONCLUSION: The incidence of CIN was 8.2%, particularly elevated in patients with ICH, hypertension, tissue plasminogen administration, and abnormal baseline, necessitating vigilance in managing acute stroke cases.
{"title":"Incidence and risk factors of contrast-induced nephropathy in acute stroke patients undergoing computed tomography angiography: A single-center study.","authors":"Muhannad A Asiri, Mohammed S Alqahtani, Saeed A Alqahtani, Mohammed M Alwadai, Naif F Alharbi, Mohammed O Aqeeli, Saeed S Alzahrani","doi":"10.17712/nsj.2023.4.20230030","DOIUrl":"10.17712/nsj.2023.4.20230030","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the prevalence and risk factors linked to contrast-induced nephropathy in this specific patient population, aiming to ensure the highest quality of clinical care.</p><p><strong>Methods: </strong>In a retrospective analysis, all patients who presented with an acute stroke to King Fahad Hospital, Jeddah, Emergency Department from March until November 2022 and underwent Computed Tomography Angiography (CTA) brain, Inclusion criteria were as follows: a baseline creatinine results and CTA examination performed within 24 hours of symptom onset and an available early (<5 days after CTA) follow-up creatinine result.</p><p><strong>Results: </strong>Among 246 stroke patients in the emergency, 182 underwent brain CTA and 8.24% had Contrast-Induced Nephropathy (CIN). intracerebral hemorrhage (ICH) increased CIN risk 7-fold (OR=6.7; 95% CI: 1.23-33.3). Abnormal baseline raised CIN risk 8-fold (OR=7.8; 95% CI: 1.74-35.1). hypertension doubled the risk for CIN (OR=2.1; 95% CI: 1.26-6.98) CONCLUSION: The incidence of CIN was 8.2%, particularly elevated in patients with ICH, hypertension, tissue plasminogen administration, and abnormal baseline, necessitating vigilance in managing acute stroke cases.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"28 4","pages":"258-263"},"PeriodicalIF":1.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10827032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41237259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.17712/nsj.2023.4.20230066
Sounira Mehri, Josef Finsterer, Osama Y Muthaffar
{"title":"Treatment of epileptic drop attacks (atonic seizures) not only depends on skills, but also etiology, tolerability, and EEG.","authors":"Sounira Mehri, Josef Finsterer, Osama Y Muthaffar","doi":"10.17712/nsj.2023.4.20230066","DOIUrl":"10.17712/nsj.2023.4.20230066","url":null,"abstract":"","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"28 4","pages":"281-282"},"PeriodicalIF":1.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10827035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41237268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How well do face masks worn by children block the release of exhaled particles?","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"28 3","pages":"207"},"PeriodicalIF":0.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3a/64/Neurosciences-28-3-207.PMC10519654.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41207260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.17712/nsj.2022.3.20220037
K. A. Quliti
Objectives: To explore depression and its associated factors in a sample of primary headache patients with a history of head-neck trauma (Ph-nT). Methods: A cross-sectional study of 120 conveniently sampled patients at Al Madinah Al Munawarah hospitals, Saudi Arabia during the period of June 2019 to December 2019 with Primary headache and history of head-neck trauma completed the depression subscale of the Depression, Anxiety and Stress Scale-21 (DASS-21), and a structured tool for demographics and clinical characteristics. Results: Prevalence of moderate to extremely severe levels of depression was 15.8%. The majority of Ph-nT were female (64.2%), had migraine (with/without aura) (57.5%), recorded no sports-related activities (65.8%), and complained of insufficient sleep (67.5%). Primary headache patients with a history of head-neck trauma, and a family history of migraine/chronic headache, had higher depression scores (β=1.77, p=0.02). Conclusion: Prevalence of depressive symptoms is higher in a sample of primary headache patients with a history of head-neck trauma than in the population that did not experience that trauma. Identification of predictors of depression in primary headache patients with a history of head-neck trauma may help in evolving targeted prevention and screening programs.
目的:探讨有头颈外伤(Ph-nT)史的原发性头痛患者抑郁及其相关因素。方法:对2019年6月至2019年12月在沙特阿拉伯Al Madinah Al Munawarah医院方便抽样的120例原发性头痛和头颈部创伤史患者进行横断面研究，完成抑郁、焦虑和压力量表-21 (das -21)的抑郁亚量表，并使用人口统计学和临床特征的结构化工具。结果:中度至极重度抑郁症患病率为15.8%。大多数Ph-nT是女性(64.2%)，有偏头痛(有/没有先兆)(57.5%)，没有记录与运动相关的活动(65.8%)，抱怨睡眠不足(67.5%)。有头颈外伤史和偏头痛/慢性头痛家族史的原发性头痛患者抑郁评分较高(β=1.77, p=0.02)。结论:有头颈外伤史的原发性头痛患者抑郁症状的患病率高于没有头颈外伤史的人群。确定头颈部创伤史的原发性头痛患者抑郁的预测因素可能有助于制定有针对性的预防和筛查方案。
{"title":"Prevalence of depressive symptoms and its correlates in primary headache patients with a history of head-neck trauma","authors":"K. A. Quliti","doi":"10.17712/nsj.2022.3.20220037","DOIUrl":"https://doi.org/10.17712/nsj.2022.3.20220037","url":null,"abstract":"Objectives: To explore depression and its associated factors in a sample of primary headache patients with a history of head-neck trauma (Ph-nT). Methods: A cross-sectional study of 120 conveniently sampled patients at Al Madinah Al Munawarah hospitals, Saudi Arabia during the period of June 2019 to December 2019 with Primary headache and history of head-neck trauma completed the depression subscale of the Depression, Anxiety and Stress Scale-21 (DASS-21), and a structured tool for demographics and clinical characteristics. Results: Prevalence of moderate to extremely severe levels of depression was 15.8%. The majority of Ph-nT were female (64.2%), had migraine (with/without aura) (57.5%), recorded no sports-related activities (65.8%), and complained of insufficient sleep (67.5%). Primary headache patients with a history of head-neck trauma, and a family history of migraine/chronic headache, had higher depression scores (β=1.77, p=0.02). Conclusion: Prevalence of depressive symptoms is higher in a sample of primary headache patients with a history of head-neck trauma than in the population that did not experience that trauma. Identification of predictors of depression in primary headache patients with a history of head-neck trauma may help in evolving targeted prevention and screening programs.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"27 1","pages":"181 - 186"},"PeriodicalIF":0.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42877913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.17712/nsj.2022.3.20220033
Qianqian Sha, Yu Xia, Xiya Shen, Ailian Du
15q11.2 BP1-BP2 microdeletion is related to clinical abnormalities including general developmental delay, speech and neuropsychiatric disorders, which is known as Angelman syndrome. However, the clinical penetrance and phenotype of 15q11.2 BP1-BP2 deletion is varied and confusing. Herein, we retrospectively described a 50-year-old male patient who manifested with progressive spastic paraplegia of lower limbs and episodic exacerbation. While brain MRI showed white matter hyperintensities, lacunes, cerebral microbleeds, enlarged perivascular spaces, and brain atrophy, mimicking small vessel disease. Next-generation sequencing combining multiplex ligation-dependent probe amplification identified a 253 kb 15q11.2 BP1-BP2 microdeletion, encompassing 4 conserved imprinted genes (NIPA1, NIPA2, CYFIP1 and TUBGCP5). This report will build new connections among spastic paraplegia, small vessel disease and 15q11.2 BP1-BP2 microdeletion.
{"title":"15q11.2 BP1-BP2 microdeletion presenting as progressive spastic paraplegia and brain images of small vessel disease","authors":"Qianqian Sha, Yu Xia, Xiya Shen, Ailian Du","doi":"10.17712/nsj.2022.3.20220033","DOIUrl":"https://doi.org/10.17712/nsj.2022.3.20220033","url":null,"abstract":"15q11.2 BP1-BP2 microdeletion is related to clinical abnormalities including general developmental delay, speech and neuropsychiatric disorders, which is known as Angelman syndrome. However, the clinical penetrance and phenotype of 15q11.2 BP1-BP2 deletion is varied and confusing. Herein, we retrospectively described a 50-year-old male patient who manifested with progressive spastic paraplegia of lower limbs and episodic exacerbation. While brain MRI showed white matter hyperintensities, lacunes, cerebral microbleeds, enlarged perivascular spaces, and brain atrophy, mimicking small vessel disease. Next-generation sequencing combining multiplex ligation-dependent probe amplification identified a 253 kb 15q11.2 BP1-BP2 microdeletion, encompassing 4 conserved imprinted genes (NIPA1, NIPA2, CYFIP1 and TUBGCP5). This report will build new connections among spastic paraplegia, small vessel disease and 15q11.2 BP1-BP2 microdeletion.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"27 1","pages":"191 - 196"},"PeriodicalIF":0.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44912996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.17712/nsj.2022.3.20210109
Zhe Shi, Yonghui Wu, Lei Su, Ying Zhou, Lan Zhang, Da Xu, Yangang Xing
Objectives: To explore the relationship between the presence or parameters of right-to-left shunt (RLS) detected by c-TCD and attack clinical features in migraine patients with aura (MA+) or without aura (MA-). Methods: Migraine patients with aura and migraine patients without aura (MA-) were recruited consecutively. The RLS was assessed by a c-TCD examination. Results: A total of 528 migraine patients and 71 healthy were included. The prevalence of RLS especially of mild shunts was higher in patients with migraine. Patients of MA+ developed migraine earlier and experienced more severe pain, more frequent photophobia and phonophobia, although the yearly frequency, duration and degree of pain or type and size of shunt was similar. Moreover, patients with MA+ and RLS (MA+RLS+) also experienced more photophobia and phonophobia than that without RLS (MA+RLS-). The result was similar in MA-RLS+ group. Patients with moderate or massive of RLS experience longer duration of pain in both MA+RLS+ and MA-RLS+ groups. The sex distribution was only significantly different in MA+RLS+ group, in which women were more likely to suffer from RLS especially mild shunt. Conclusion: A higher prevalence and severity of RLS was found in the migraine patients, especially those with aura. MA+ patients develop earlier and experience more severe pain. The duration was consistent with the shunt size in both MA+RLS+ and MA-RLS+ groups.
{"title":"Relationship between right-to-left shunt detected by c-TCD and clinical characteristics in migraine patients","authors":"Zhe Shi, Yonghui Wu, Lei Su, Ying Zhou, Lan Zhang, Da Xu, Yangang Xing","doi":"10.17712/nsj.2022.3.20210109","DOIUrl":"https://doi.org/10.17712/nsj.2022.3.20210109","url":null,"abstract":"Objectives: To explore the relationship between the presence or parameters of right-to-left shunt (RLS) detected by c-TCD and attack clinical features in migraine patients with aura (MA+) or without aura (MA-). Methods: Migraine patients with aura and migraine patients without aura (MA-) were recruited consecutively. The RLS was assessed by a c-TCD examination. Results: A total of 528 migraine patients and 71 healthy were included. The prevalence of RLS especially of mild shunts was higher in patients with migraine. Patients of MA+ developed migraine earlier and experienced more severe pain, more frequent photophobia and phonophobia, although the yearly frequency, duration and degree of pain or type and size of shunt was similar. Moreover, patients with MA+ and RLS (MA+RLS+) also experienced more photophobia and phonophobia than that without RLS (MA+RLS-). The result was similar in MA-RLS+ group. Patients with moderate or massive of RLS experience longer duration of pain in both MA+RLS+ and MA-RLS+ groups. The sex distribution was only significantly different in MA+RLS+ group, in which women were more likely to suffer from RLS especially mild shunt. Conclusion: A higher prevalence and severity of RLS was found in the migraine patients, especially those with aura. MA+ patients develop earlier and experience more severe pain. The duration was consistent with the shunt size in both MA+RLS+ and MA-RLS+ groups.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"27 1","pages":"143 - 149"},"PeriodicalIF":0.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46664020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.17712/nsj.2022.3.20210140
Ibrahim A. Alhalal, Hashem T. Al-Salman, A. A. Anazi
Lumboperitoneal (LP) shunt is considered as a unique procedure in neurosurgical practice. The over drainage of Cerebrospinal fluid (CSF) is considered a usual side effect of the procedure that usually manifests in the form of subdural collection, headache, or nausea and vomiting. However, cranial nerve palsy, particularly abducens nerve palsy, is a rare manifestation of CSF over drainage. We describe our experience with a patient that has developed bilateral sixth nerve palsy followed by LP shunt insertion, with resolution of the symptoms upon removal of the shunt. This shades the light on a rare but significant complication related to Lumboperitoneal (LP) shunt insertion that necessitate the modification in the hardware of valve or insertion technique to decrease the risk of CSF over the drainage.
{"title":"Bilateral sixth cranial nerve palsy following lumboperitoneal shunt","authors":"Ibrahim A. Alhalal, Hashem T. Al-Salman, A. A. Anazi","doi":"10.17712/nsj.2022.3.20210140","DOIUrl":"https://doi.org/10.17712/nsj.2022.3.20210140","url":null,"abstract":"Lumboperitoneal (LP) shunt is considered as a unique procedure in neurosurgical practice. The over drainage of Cerebrospinal fluid (CSF) is considered a usual side effect of the procedure that usually manifests in the form of subdural collection, headache, or nausea and vomiting. However, cranial nerve palsy, particularly abducens nerve palsy, is a rare manifestation of CSF over drainage. We describe our experience with a patient that has developed bilateral sixth nerve palsy followed by LP shunt insertion, with resolution of the symptoms upon removal of the shunt. This shades the light on a rare but significant complication related to Lumboperitoneal (LP) shunt insertion that necessitate the modification in the hardware of valve or insertion technique to decrease the risk of CSF over the drainage.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"27 1","pages":"187 - 190"},"PeriodicalIF":0.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49112200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.17712/nsj.2022.3.20210058
Y. Malik, S. Karmastaji, Khulood K. AlJarman, Y. Abdelmajid, Muna H. Lootah, J. Dar, A. Almadani
Objectives: To assess the impact of the COVID-19 pandemic on migraineur’s quality of life and confounding factors. Methods: This is an observational cohort study conducted in Rashid hospital, Dubai Health Authority, UAE. Study was plotted to assess migraine indices in pre-COVID period, pre-pandemic and pandemic periods and to evaluate the pandemic induced paradigm shift in migraine management. Results: Out of 840 migraineurs 201 patients were selected, with an obvious female predominance (78%). Migraine without Aura was found in 70% and Migraine with Aura in 29.9%. Mean MIDAS score during period I, II and II was 22.78, 18.58 and 17.92 respectively indicating certain degree of improvement rather than deterioration during pandemic (p=0.001). Interestingly significant reduction in both migraine frequency and severity from pre-COVID to COVID period was noticed (p=0.01). Parameters like headache days/month, use of abortive therapy and Emergency visits also declined. Chronic migraine (CM) showed more improvement than episodic migraine (EM). Confounding factors like distance working and lack of social/professional stress mainly rendered this change. A modified strategy to handle headache during any pandemic/crisis can ensure quality management of migraine. Conclusion: Migraine patients had a resilient behavior during the COVID pandemic and showed significant improvement of all indices. Confounding factors like distance working played the most favorable role.
{"title":"Paradigm shift in migraine management impacted by COVID-19 pandemic and the role of confounding factors inflicting the change","authors":"Y. Malik, S. Karmastaji, Khulood K. AlJarman, Y. Abdelmajid, Muna H. Lootah, J. Dar, A. Almadani","doi":"10.17712/nsj.2022.3.20210058","DOIUrl":"https://doi.org/10.17712/nsj.2022.3.20210058","url":null,"abstract":"Objectives: To assess the impact of the COVID-19 pandemic on migraineur’s quality of life and confounding factors. Methods: This is an observational cohort study conducted in Rashid hospital, Dubai Health Authority, UAE. Study was plotted to assess migraine indices in pre-COVID period, pre-pandemic and pandemic periods and to evaluate the pandemic induced paradigm shift in migraine management. Results: Out of 840 migraineurs 201 patients were selected, with an obvious female predominance (78%). Migraine without Aura was found in 70% and Migraine with Aura in 29.9%. Mean MIDAS score during period I, II and II was 22.78, 18.58 and 17.92 respectively indicating certain degree of improvement rather than deterioration during pandemic (p=0.001). Interestingly significant reduction in both migraine frequency and severity from pre-COVID to COVID period was noticed (p=0.01). Parameters like headache days/month, use of abortive therapy and Emergency visits also declined. Chronic migraine (CM) showed more improvement than episodic migraine (EM). Confounding factors like distance working and lack of social/professional stress mainly rendered this change. A modified strategy to handle headache during any pandemic/crisis can ensure quality management of migraine. Conclusion: Migraine patients had a resilient behavior during the COVID pandemic and showed significant improvement of all indices. Confounding factors like distance working played the most favorable role.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"27 1","pages":"156 - 163"},"PeriodicalIF":0.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45428982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.17712/nsj.2022.3.20210146
Tareef S Daqqaq, Ayman S. Alhasan
Objectives: To assess and compare the diagnostic accuracy, sensitivity and specificity of perfusion-weighted imaging (PWI) and positron emission tomography (PET) in distinguishing between treatment-related changes and tumor recurrence. Methods: We carried out a systematic review of PubMed, Embase, Web of Science, the Cochrane Library, and CINAHL databases from database inception until August 2021 for pertinent articles. Particular inclusion and exclusion criteria were applied to select the eligible studies. The Quality Assessment of Diagnostic Accuracy tool was used to assess the risk of bias and methodological quality of the eligible studies. From the included studies, the rate ratio (RR) of pooled accuracy, sensitivity, specificity and their corresponding confidence intervals (CIs) were estimated for both PWI and PET. Results: The systematic review and meta-analysis comprised 14 research studies, with a total of 542 patients. Although PET revealed a moderately higher accuracy and sensitivity when compared to PWI (RR: 0.94, 95% CI 0.86-1.02 and RR: 0.95 95% CI 0.85-1.06, respectively), the difference was not statistically significant (p>0.05). Similarly, while PWI demonstrated a moderately higher specificity when compared to PET (RR:1.10, 95% CI 0.98-1.23) but. However, no statistically significant difference between the 2 modalities was detected (p>0.05). Interestingly, we revealed that 18F-FET-PET was significantly more efficient than PWI in terms of accuracy (RR: 0.82, 95% CI 0.72-0.93) and sensitivity (RR: 0.72, 95% CI 0.62-0.83) (p>0.05). Conclusion: Both PET and PWI yielded good diagnostic performance in distinguishing treatment-related changes from tumor recurrence, and neither modality seemed to be superior. PROSPERO ID: CRD42021288160
目的：评估和比较灌注加权成像（PWI）和正电子发射断层扫描（PET）在区分治疗相关变化和肿瘤复发方面的诊断准确性、敏感性和特异性。方法：我们对PubMed、Embase、Web of Science、Cochrane Library和CINAHL数据库从数据库创建到2021年8月的相关文章进行了系统综述。采用特殊的纳入和排除标准来选择符合条件的研究。诊断准确性质量评估工具用于评估合格研究的偏倚风险和方法学质量。从纳入的研究中，对PWI和PET的合并准确性、敏感性、特异性及其相应的置信区间（CI）的比率比（RR）进行了估计。结果：系统综述和荟萃分析包括14项研究，共542名患者。尽管与PWI相比，PET显示出适度更高的准确性和敏感性（RR:0.94，95%CI 0.86-1.02和RR:0.95，95%CI为0.85-1.06），但差异无统计学意义（p>0.05）。同样，与PET相比，PWI显示出适度较高的特异性（RR:1.10，95%CI 0.98-1.23），但是。然而，两种模式之间没有统计学上的显著差异（p>0.05）。有趣的是，我们发现18F-FET-PET在准确性（RR:0.82，95%CI 0.72-0.93）和敏感性（RR:0.72，95%CI 0.62-0.83）方面显著高于PWI（p>0.05）。PROSPERO ID:CRD42021288160
{"title":"Positron emission tomography and perfusion weighted imaging in the detection of brain tumors recurrence","authors":"Tareef S Daqqaq, Ayman S. Alhasan","doi":"10.17712/nsj.2022.3.20210146","DOIUrl":"https://doi.org/10.17712/nsj.2022.3.20210146","url":null,"abstract":"Objectives: To assess and compare the diagnostic accuracy, sensitivity and specificity of perfusion-weighted imaging (PWI) and positron emission tomography (PET) in distinguishing between treatment-related changes and tumor recurrence. Methods: We carried out a systematic review of PubMed, Embase, Web of Science, the Cochrane Library, and CINAHL databases from database inception until August 2021 for pertinent articles. Particular inclusion and exclusion criteria were applied to select the eligible studies. The Quality Assessment of Diagnostic Accuracy tool was used to assess the risk of bias and methodological quality of the eligible studies. From the included studies, the rate ratio (RR) of pooled accuracy, sensitivity, specificity and their corresponding confidence intervals (CIs) were estimated for both PWI and PET. Results: The systematic review and meta-analysis comprised 14 research studies, with a total of 542 patients. Although PET revealed a moderately higher accuracy and sensitivity when compared to PWI (RR: 0.94, 95% CI 0.86-1.02 and RR: 0.95 95% CI 0.85-1.06, respectively), the difference was not statistically significant (p>0.05). Similarly, while PWI demonstrated a moderately higher specificity when compared to PET (RR:1.10, 95% CI 0.98-1.23) but. However, no statistically significant difference between the 2 modalities was detected (p>0.05). Interestingly, we revealed that 18F-FET-PET was significantly more efficient than PWI in terms of accuracy (RR: 0.82, 95% CI 0.72-0.93) and sensitivity (RR: 0.72, 95% CI 0.62-0.83) (p>0.05). Conclusion: Both PET and PWI yielded good diagnostic performance in distinguishing treatment-related changes from tumor recurrence, and neither modality seemed to be superior. PROSPERO ID: CRD42021288160","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"27 1","pages":"131 - 142"},"PeriodicalIF":0.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47105332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.17712/nsj.2022.3.20210141
B. Al-Jabri, Refal M. Abualhamael, Maryam T. Al Hazza, Salwa A. Bahabri, Yara M. Alamri, Bayan M. Alghamdi
Objectives: To assess the impact on quality of life (QOL) caused by caring for children with autism spectrum disorder (ASD) and examine the impact according to provincial residence. Methods: This was an observational, cross-sectional study conducted from May to July 2019 at King Abdulaziz University Hospital in Jeddah. Eight hundred and twelve participants were included and divided equally into caregivers of children with and without ASDs. Data were collected through an online questionnaire distributed via autism associations and parental support groups across all 13 Saudi Arabian provinces. Results: Caregivers of children with ASDs showed lower scores in most quality-of-life domains compared with those of caregivers of children without ASDs (p<0.05, except for one domain). The impacts of additional factors were considered, including the caregivers’ age, the relation of the caregiver to the child, the specific province of residence, and the provision of medical services. Conclusion: A significant negative correlation was found between caregiving for children with ASDs and quality-of-life scores.
{"title":"Quality of life of caregivers of autistic children in Saudi Arabia: Cross-sectional study","authors":"B. Al-Jabri, Refal M. Abualhamael, Maryam T. Al Hazza, Salwa A. Bahabri, Yara M. Alamri, Bayan M. Alghamdi","doi":"10.17712/nsj.2022.3.20210141","DOIUrl":"https://doi.org/10.17712/nsj.2022.3.20210141","url":null,"abstract":"Objectives: To assess the impact on quality of life (QOL) caused by caring for children with autism spectrum disorder (ASD) and examine the impact according to provincial residence. Methods: This was an observational, cross-sectional study conducted from May to July 2019 at King Abdulaziz University Hospital in Jeddah. Eight hundred and twelve participants were included and divided equally into caregivers of children with and without ASDs. Data were collected through an online questionnaire distributed via autism associations and parental support groups across all 13 Saudi Arabian provinces. Results: Caregivers of children with ASDs showed lower scores in most quality-of-life domains compared with those of caregivers of children without ASDs (p<0.05, except for one domain). The impacts of additional factors were considered, including the caregivers’ age, the relation of the caregiver to the child, the specific province of residence, and the provision of medical services. Conclusion: A significant negative correlation was found between caregiving for children with ASDs and quality-of-life scores.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"27 1","pages":"150 - 155"},"PeriodicalIF":0.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49365470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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