{"title":"Blood Fatty Acid Changes in Female Long-Distance Athletes after EPA and DHA Supplementation for 24 Months","authors":"A. Kawamura, M. Sugita","doi":"10.4327/jsnfs.73.199","DOIUrl":"https://doi.org/10.4327/jsnfs.73.199","url":null,"abstract":"","PeriodicalId":19296,"journal":{"name":"Nippon Eiyo Shokuryo Gakkaishi","volume":"7 1","pages":"199-205"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86242371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Summary : The biological phosphate regulatory system plays an important role in longevity and aging. Recent work focusing on the aging suppressor gene Klotho suggests that “ phosphate accelerates aging ” , thereby di-recting the focus toward various diseases caused by an abnormal phosphate balance mediated by the fibroblast growth factor 23 （ FGF 23） /Klotho/Vitamin D axis. In the present study, using knock-out mice and cultured cells, we revealed that the FGF 23 /Klotho/Vitamin D axis mediates mineral homeostasis from early develop-ment to late adulthood. Our findings suggest that the biological vitamin D status in chronic diseases can control aging. Analysis of methods to suppress aging by modifying phosphate and vitamin D metabolism in association with the prevention or improvement of progressive chronic kidney disease or cerebral dysfunction could help to promote a healthy life and slow the aging process through a nutritional approach.
{"title":"Molecular Nutritional Study of Phosphate and Vitamin D Metabolism","authors":"I. Kaneko","doi":"10.4327/jsnfs.73.3","DOIUrl":"https://doi.org/10.4327/jsnfs.73.3","url":null,"abstract":"Summary : The biological phosphate regulatory system plays an important role in longevity and aging. Recent work focusing on the aging suppressor gene Klotho suggests that “ phosphate accelerates aging ” , thereby di-recting the focus toward various diseases caused by an abnormal phosphate balance mediated by the fibroblast growth factor 23 （ FGF 23） /Klotho/Vitamin D axis. In the present study, using knock-out mice and cultured cells, we revealed that the FGF 23 /Klotho/Vitamin D axis mediates mineral homeostasis from early develop-ment to late adulthood. Our findings suggest that the biological vitamin D status in chronic diseases can control aging. Analysis of methods to suppress aging by modifying phosphate and vitamin D metabolism in association with the prevention or improvement of progressive chronic kidney disease or cerebral dysfunction could help to promote a healthy life and slow the aging process through a nutritional approach.","PeriodicalId":19296,"journal":{"name":"Nippon Eiyo Shokuryo Gakkaishi","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90303445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shun Sato, Ryuji Nagata, N. Fukuma, K. Shimada, Taiga Tamiya, Yasunori Nakayama, Kyu‐Ho Han, M. Fukushima
Summary : “ BARLEYmax ” （ BM ） is a variety of barley that is a superior source of dietary fiber and resistant starch. This study examined the colonic fermentation properties of BM in comparison to a conventional variety, “ Hindmarsh ” , relative to cellulose as a control under two experimental conditions. The residues of barley sam-ples after hydrolysis with two digestive enzymes were tested in vitro for 48 h. In phase 1 , the effects using different sample weights were examined, whereas in phase 2 , the effects under various sample weights were de-termined considering that the resistant fraction per gram of flour is higher for BM. In phase 1 , short-chain fatty acid （ SCFA ） concentrations of BM at 24 to 48 h of incubation were significantly higher in comparison to those of Hindmarsh. In phase 2 , SCFA and ammonia concentrations were significantly higher and lower, respectively, for BM throughout the incubation period relative to Hindmarsh. From these results it can be assumed that the higher amount of the fermentable indigestible fraction in BM has more beneficial intestinal fermentation properties and leads to higher production of SCFA for an extended period.
{"title":"Abundant Indigestible Carbohydrate Fraction in BARLEYmax Influences Colonic Fermentation Properties In Vitro","authors":"Shun Sato, Ryuji Nagata, N. Fukuma, K. Shimada, Taiga Tamiya, Yasunori Nakayama, Kyu‐Ho Han, M. Fukushima","doi":"10.4327/jsnfs.73.81","DOIUrl":"https://doi.org/10.4327/jsnfs.73.81","url":null,"abstract":"Summary : “ BARLEYmax ” （ BM ） is a variety of barley that is a superior source of dietary fiber and resistant starch. This study examined the colonic fermentation properties of BM in comparison to a conventional variety, “ Hindmarsh ” , relative to cellulose as a control under two experimental conditions. The residues of barley sam-ples after hydrolysis with two digestive enzymes were tested in vitro for 48 h. In phase 1 , the effects using different sample weights were examined, whereas in phase 2 , the effects under various sample weights were de-termined considering that the resistant fraction per gram of flour is higher for BM. In phase 1 , short-chain fatty acid （ SCFA ） concentrations of BM at 24 to 48 h of incubation were significantly higher in comparison to those of Hindmarsh. In phase 2 , SCFA and ammonia concentrations were significantly higher and lower, respectively, for BM throughout the incubation period relative to Hindmarsh. From these results it can be assumed that the higher amount of the fermentable indigestible fraction in BM has more beneficial intestinal fermentation properties and leads to higher production of SCFA for an extended period.","PeriodicalId":19296,"journal":{"name":"Nippon Eiyo Shokuryo Gakkaishi","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78058367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kazuma Yoshizumi, Hiroto Kumakura, Misa Fujinami, T. Hosoya, S. Kumazawa, Yumiko Hori
Summary : Unrefined palmyra palm sugar contains high amounts of polyphenols and minerals, making it a po-tential sucrose substitute and/or nutraceutical for prevention of lifestyle-related diseases. We therefore evaluat-ed the total polyphenol content and antioxidant activity of palm sugar and studied the effects of single-dose and long-term palm sugar administration on the blood glucose response in mice. This revealed that the total polyphenol content of palm sugar from Cambodia was slightly lower than that of brown sugar from Okinawa, and that palm sugar had a higher oxygen radical absorbance capacity than coconut sugar or maple syrup. Mouse delta blood glucose levels at 30 , 120 , and 180 minutes after single-dose administration of palm sugar were significantly lower than those after single-dose administration of sucrose （30 min, p ＜0 . 01 ; 120 and 180 min, p ＜0 . 05） ; moreover, the delta area under the curve was significantly lower for palm sugar than for sucrose （ p ＜0 . 01 ） . Fasting blood glucose levels, measured every two weeks to evaluate long-term intake, did not increase during the experimental period of about 3 months. We suggest that palm sugar is a sweetener with a more moderate elevation effect on blood glucose.
{"title":"Effect of Ingestion of Palm Sugar from Cambodia on the Blood Glucose Response in Mice","authors":"Kazuma Yoshizumi, Hiroto Kumakura, Misa Fujinami, T. Hosoya, S. Kumazawa, Yumiko Hori","doi":"10.4327/jsnfs.73.237","DOIUrl":"https://doi.org/10.4327/jsnfs.73.237","url":null,"abstract":"Summary : Unrefined palmyra palm sugar contains high amounts of polyphenols and minerals, making it a po-tential sucrose substitute and/or nutraceutical for prevention of lifestyle-related diseases. We therefore evaluat-ed the total polyphenol content and antioxidant activity of palm sugar and studied the effects of single-dose and long-term palm sugar administration on the blood glucose response in mice. This revealed that the total polyphenol content of palm sugar from Cambodia was slightly lower than that of brown sugar from Okinawa, and that palm sugar had a higher oxygen radical absorbance capacity than coconut sugar or maple syrup. Mouse delta blood glucose levels at 30 , 120 , and 180 minutes after single-dose administration of palm sugar were significantly lower than those after single-dose administration of sucrose （30 min, p ＜0 . 01 ; 120 and 180 min, p ＜0 . 05） ; moreover, the delta area under the curve was significantly lower for palm sugar than for sucrose （ p ＜0 . 01 ） . Fasting blood glucose levels, measured every two weeks to evaluate long-term intake, did not increase during the experimental period of about 3 months. We suggest that palm sugar is a sweetener with a more moderate elevation effect on blood glucose.","PeriodicalId":19296,"journal":{"name":"Nippon Eiyo Shokuryo Gakkaishi","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82037461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Kanamoto, Hikaru Kanazawa, Mayu Uchida, Yasuo Nakatsuka, Yukitoshi Yamamoto, Y. Nakanishi, H. Sasaki, Arisa Kaneko, I. Murata, Y. Inoue
Summary : Changes in postprandial blood glucose were measured after ingestion of two types of low-carbohy-drate (CHO) bread in comparison with plain and whole-grain breads. The effects of a second meal and CHO digestibility were also investigated. The subjects were 11 healthy adults ( 2 males and 9 females). Plain (net CHO: 38 . 6 g), whole-grain (net CHO: 36 g), mildly low-CHO (net CHO: 8 . 5 g, high protein), and super-low-CHO (net CHO: 3 . 4 g, high protein and high fat) breads were ingested for breakfast. In addition, four tests were conduct-ed in which curry and rice were eaten for lunch, and postprandial blood glucose was measured over time. CHO digestibility was measured using the in vitro Glucose Releasing Rate method. It was found that the blood glucose level was low after ingestion of mildly or super-low-CHO bread, but no second-meal effect was observed. In terms of digestibility, postprandial blood glucose level and satiety, mildly low-CHO bread was considered to be superior among the two types of low-CHO bread used in this study.
{"title":"The Effects of Low-carbohydrate Bread Intake on the Postprandial Glycemic Response of Healthy Adults Following a Second Meal","authors":"I. Kanamoto, Hikaru Kanazawa, Mayu Uchida, Yasuo Nakatsuka, Yukitoshi Yamamoto, Y. Nakanishi, H. Sasaki, Arisa Kaneko, I. Murata, Y. Inoue","doi":"10.4327/jsnfs.73.133","DOIUrl":"https://doi.org/10.4327/jsnfs.73.133","url":null,"abstract":"Summary : Changes in postprandial blood glucose were measured after ingestion of two types of low-carbohy-drate (CHO) bread in comparison with plain and whole-grain breads. The effects of a second meal and CHO digestibility were also investigated. The subjects were 11 healthy adults ( 2 males and 9 females). Plain (net CHO: 38 . 6 g), whole-grain (net CHO: 36 g), mildly low-CHO (net CHO: 8 . 5 g, high protein), and super-low-CHO (net CHO: 3 . 4 g, high protein and high fat) breads were ingested for breakfast. In addition, four tests were conduct-ed in which curry and rice were eaten for lunch, and postprandial blood glucose was measured over time. CHO digestibility was measured using the in vitro Glucose Releasing Rate method. It was found that the blood glucose level was low after ingestion of mildly or super-low-CHO bread, but no second-meal effect was observed. In terms of digestibility, postprandial blood glucose level and satiety, mildly low-CHO bread was considered to be superior among the two types of low-CHO bread used in this study.","PeriodicalId":19296,"journal":{"name":"Nippon Eiyo Shokuryo Gakkaishi","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82814808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Tomotake, Kazuko Yasutomi, Yukiko Tomiguchi, Sayaka Yamashita, T. Kohri
{"title":"The Effects of Mastication, Nutrition and Exercise Guidance in a Health Program for the Elderly","authors":"H. Tomotake, Kazuko Yasutomi, Yukiko Tomiguchi, Sayaka Yamashita, T. Kohri","doi":"10.4327/jsnfs.73.207","DOIUrl":"https://doi.org/10.4327/jsnfs.73.207","url":null,"abstract":"","PeriodicalId":19296,"journal":{"name":"Nippon Eiyo Shokuryo Gakkaishi","volume":"12 1","pages":"207-213"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75646613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Summary ： Modification of lifestyle including nutrition therapy plays a fundamental role in the treatment of type 2 diabetes. Because of the wide diversity in the pathogenesis of diabetes and lifestyle, nutrition therapy needs to be tailored to individual patients. Management of obesity by reduction of body weight is a critical issue for amelioration of insulin resistance. So far, a BMI of 22 has been considered the standard for Japanese, and total energy intake is calculated in order to achieve this. However, energy requirement differs among individuals according to age and physical activity, and a BMI of 22 is not an achievable target for those with an existing BMI of over 30 . On the other hand, nutrition therapy should aim to prevent frailty and sarcopenia in elderly patients by ensuring that energy and protein intakes are sufficient. On the basis on these considerations, the Japanese Diabetes Society has proposed new guidelines for nutrition therapy focusing on individualization of energy and macronutrient intakes.
{"title":"Perspectives of Nutrition Therapy for Type 2 Diabetes: Individualization Based on Dietary Reference Intake for Japanese, 2020","authors":"K. Utsunomiya","doi":"10.4327/jsnfs.73.193","DOIUrl":"https://doi.org/10.4327/jsnfs.73.193","url":null,"abstract":"Summary ： Modification of lifestyle including nutrition therapy plays a fundamental role in the treatment of type 2 diabetes. Because of the wide diversity in the pathogenesis of diabetes and lifestyle, nutrition therapy needs to be tailored to individual patients. Management of obesity by reduction of body weight is a critical issue for amelioration of insulin resistance. So far, a BMI of 22 has been considered the standard for Japanese, and total energy intake is calculated in order to achieve this. However, energy requirement differs among individuals according to age and physical activity, and a BMI of 22 is not an achievable target for those with an existing BMI of over 30 . On the other hand, nutrition therapy should aim to prevent frailty and sarcopenia in elderly patients by ensuring that energy and protein intakes are sufficient. On the basis on these considerations, the Japanese Diabetes Society has proposed new guidelines for nutrition therapy focusing on individualization of energy and macronutrient intakes.","PeriodicalId":19296,"journal":{"name":"Nippon Eiyo Shokuryo Gakkaishi","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80471435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kihara, Hiyu Kanbe, M. Kitamura, Ryota Watanabe
Summary : We analyzed the nutritional components of the hermit crab Pagurus ochotensis , an untapped poten-tial marine resource. Deshelled whole P. ochotensis specimens with the exoskeleton were analyzed for proxi-mate composition and heavy metals, and partly divided specimens along with the exoskeleton were also analyzed for free amino acids and fatty acids. The lipid, ash and carbohydrate contents were high, whereas the water content was low, due to inclusion of the exoskeleton. Mercury, lead, and cadmium were not detected. The total arsenic content was 0 . 77 ppm. The total free amino acid and taurine contents were higher than those of the snow crab, Chionoecetes opilio . P. ochotensis also contained anserine and carnosine. The abdomen had high levels of eicosapentaenoic acid （ EPA ） and docosahexaenoic acid （ DHA ） （1 , 600 mg and 800 mg per 100 g, respec-tively ） , although there was some seasonal variation. Interestingly, the EPA content was higher than that of blue-fin tuna （1 , 400 mg per 100 g belly meat ） . Because there are some reports of human consumption, and the heavy metal content of P. ochotensis is not problematic as a foodstuff, we conclude that it could be used as a food resource. Nutritionally, P. ochotensis is characterized by high levels of free amino acids, taurine, anserine, and carnosine, as well as a high content of the functional fatty acids EPA and DHA.
{"title":"Analysis of Nutritional Components of the Hermit Crab Pagurus ochotensis for Human Consumption","authors":"M. Kihara, Hiyu Kanbe, M. Kitamura, Ryota Watanabe","doi":"10.4327/jsnfs.73.247","DOIUrl":"https://doi.org/10.4327/jsnfs.73.247","url":null,"abstract":"Summary : We analyzed the nutritional components of the hermit crab Pagurus ochotensis , an untapped poten-tial marine resource. Deshelled whole P. ochotensis specimens with the exoskeleton were analyzed for proxi-mate composition and heavy metals, and partly divided specimens along with the exoskeleton were also analyzed for free amino acids and fatty acids. The lipid, ash and carbohydrate contents were high, whereas the water content was low, due to inclusion of the exoskeleton. Mercury, lead, and cadmium were not detected. The total arsenic content was 0 . 77 ppm. The total free amino acid and taurine contents were higher than those of the snow crab, Chionoecetes opilio . P. ochotensis also contained anserine and carnosine. The abdomen had high levels of eicosapentaenoic acid （ EPA ） and docosahexaenoic acid （ DHA ） （1 , 600 mg and 800 mg per 100 g, respec-tively ） , although there was some seasonal variation. Interestingly, the EPA content was higher than that of blue-fin tuna （1 , 400 mg per 100 g belly meat ） . Because there are some reports of human consumption, and the heavy metal content of P. ochotensis is not problematic as a foodstuff, we conclude that it could be used as a food resource. Nutritionally, P. ochotensis is characterized by high levels of free amino acids, taurine, anserine, and carnosine, as well as a high content of the functional fatty acids EPA and DHA.","PeriodicalId":19296,"journal":{"name":"Nippon Eiyo Shokuryo Gakkaishi","volume":"371 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74209137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Study of the Effect of Diet and Physical Activity on Bone Metabolism","authors":"Y. Ishimi","doi":"10.4327/JSNFS.72.71","DOIUrl":"https://doi.org/10.4327/JSNFS.72.71","url":null,"abstract":"","PeriodicalId":19296,"journal":{"name":"Nippon Eiyo Shokuryo Gakkaishi","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78026573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Summary : We examined whether oral immunotherapy （ OIT ） using a diet supplemented with 0 . 1％ egg white ameliorates the severity of allergy and immunological tolerance to an extent comparable to OIT by oral gavage. Allergy to egg white was induced in mice via peritoneal administration of egg white-mixed aluminum hydroxide gel, and the allergy reaction was induced via oral gavage of egg white. Mice sensitized with egg white were di-vided into three groups （ untreated group, oral gavage group, and diet group ） , and non-sensitized mice were also prepared. The OIT period lasted 4 weeks. The diet group was fed a 20％ casein diet containing 0 . 1％ egg white, and the other groups were fed a 20％ casein diet alone. Furthermore, the oral gavage group was forcibly administered 100 μ L of 30 mg/mL egg white solution orally every day, while each of the other groups received 100 μ L of phosphate-buffered saline by daily forced oral gavage. The change in rectal temperature following in-traperitoneal food challenge was inhibited to a greater degree in the oral gavage and diet groups than in the untreated group. Moreover, the ovalbumin-specific IgE concentrations and ovomucoid-specific IgE titers in plasma were lower in the oral gavage and diet groups than in the untreated group. However, these antibodies did not differ between the oral gavage and diet groups. These findings suggest that if the amount of allergen ingested per day is small and equivalent, continuous intake of the allergen has therapeutic efficacy similar to that of sin-gle oral administration of the allergen.
摘要:我们研究了口服免疫疗法(OIT)是否使用在饮食中添加0。1%蛋清改善过敏和免疫耐受的严重程度，其程度与口服灌胃OIT相当。通过蛋清混合氢氧化铝凝胶腹腔注射诱导小鼠对蛋清过敏，并通过蛋清灌胃诱导过敏反应。将蛋清致敏小鼠分为3组(未处理组、灌胃组、日粮组)，另取未致敏小鼠。OIT期为4周。饲粮组饲喂酪蛋白含量为20%的饲粮。1%的蛋清，其他组只喂食20%的酪蛋白。另外，灌胃组小鼠每天灌胃100 μ L 30 mg/mL的蛋清溶液，其余各组小鼠每天灌胃100 μ L磷酸盐缓冲盐水。与未处理组相比，口服灌胃组和饮食组腹腔内食物刺激后直肠温度的变化受到更大程度的抑制。此外，灌胃组和饲粮组血浆中卵清蛋白特异性IgE浓度和卵样蛋白特异性IgE滴度均低于未治疗组。然而，这些抗体在灌胃组和饮食组之间没有差异。这些发现表明，如果每天摄入的过敏原量很小且相当，持续摄入过敏原的治疗效果与单次口服过敏原的治疗效果相似。
{"title":"Oral Immunotherapy Using Diet Supplemented with 0.1％ Egg White Ameliorates the Severity of Allergy to an Extent Comparable to Oral Gavage Therapy","authors":"Marin Matsushima, Akihiro Maeta, Kyoko Takahashi","doi":"10.4327/JSNFS.72.3","DOIUrl":"https://doi.org/10.4327/JSNFS.72.3","url":null,"abstract":"Summary : We examined whether oral immunotherapy （ OIT ） using a diet supplemented with 0 . 1％ egg white ameliorates the severity of allergy and immunological tolerance to an extent comparable to OIT by oral gavage. Allergy to egg white was induced in mice via peritoneal administration of egg white-mixed aluminum hydroxide gel, and the allergy reaction was induced via oral gavage of egg white. Mice sensitized with egg white were di-vided into three groups （ untreated group, oral gavage group, and diet group ） , and non-sensitized mice were also prepared. The OIT period lasted 4 weeks. The diet group was fed a 20％ casein diet containing 0 . 1％ egg white, and the other groups were fed a 20％ casein diet alone. Furthermore, the oral gavage group was forcibly administered 100 μ L of 30 mg/mL egg white solution orally every day, while each of the other groups received 100 μ L of phosphate-buffered saline by daily forced oral gavage. The change in rectal temperature following in-traperitoneal food challenge was inhibited to a greater degree in the oral gavage and diet groups than in the untreated group. Moreover, the ovalbumin-specific IgE concentrations and ovomucoid-specific IgE titers in plasma were lower in the oral gavage and diet groups than in the untreated group. However, these antibodies did not differ between the oral gavage and diet groups. These findings suggest that if the amount of allergen ingested per day is small and equivalent, continuous intake of the allergen has therapeutic efficacy similar to that of sin-gle oral administration of the allergen.","PeriodicalId":19296,"journal":{"name":"Nippon Eiyo Shokuryo Gakkaishi","volume":"262 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86718554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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