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Nihon saikingaku zasshi. Japanese journal of bacteriology最新文献

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[Luncheon Seminar]. (午餐研讨会)。
Pub Date : 2023-01-01 DOI: 10.3412/jsb.78.155
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引用次数: 0
[Poster]. (海报)。
Pub Date : 2023-01-01 DOI: 10.3412/jsb.78.62
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引用次数: 0
[Special Session]. 特别会议。
Pub Date : 2022-01-01 DOI: 10.3412/jsb.77.7
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引用次数: 0
[Genome analysis-based studies on bacterial genetic diversity]. [基于基因组分析的细菌遗传多样性研究]。
Pub Date : 2022-01-01 DOI: 10.3412/jsb.77.145
Tetsuya Hayashi

There are a huge number of bacterial species on earth, and a huge intra-species genomic diversity are also observed in many bacteria. The high ability of bacteria to acquire foreign DNA and the presence of various mobile genetic elements contribute the generation of such genomic diversity. During the biochemical and genetic analysis of a Pseudomonas aeruginosa toxin, called cytotoxin, and its converting phage, which I first engaged in my research carrier, I became very interested in the genetic diversity of bacteria and mobile genetic elements such as bacteriophages, and realized the usefulness and power of genome analysis. Since then, I have been involved in genome analyses of various pathogenic bacteria such as enterohemorrhagic Escherichia coli (EHEC), commensal bacteria of human and other animals, and bacteria or bacterial communities in natural environments. I was so lucky that I jumped in this research field at the very begging of genome analyses and experienced a very exciting time of surprisingly rapid advance in genome sequencing technologies which revolutionized a wide range of biology. In this article, I first review the main findings which our group obtained from the genome analyses on the P. aeruginosa cytotoxin converting phage and those on the evolution and genomic diversity of EHEC and related bacteria. The results of our analyses of Rickettsiaceae family genomes, which show surprisingly very low genomic diversity, and genome sequence-based analyses of an intrahospital bacterial outbreak and within-host genomic diversity are also summarized.

地球上的细菌种类非常多,在许多细菌中也观察到巨大的种内基因组多样性。细菌获得外源DNA的高能力和各种可移动遗传元件的存在促成了这种基因组多样性的产生。在对一种叫做细胞毒素的铜绿假单胞菌毒素及其转化噬菌体的生化和遗传分析过程中,我第一次从事了我的研究载体,我对细菌的遗传多样性和噬菌体等可移动遗传元件产生了浓厚的兴趣,并意识到基因组分析的有用性和力量。从那时起,我一直参与各种致病菌的基因组分析,如肠出血性大肠杆菌(EHEC),人类和其他动物的共生细菌,以及自然环境中的细菌或细菌群落。我很幸运,在基因组分析的迫切需要下进入了这个研究领域,经历了基因组测序技术惊人快速发展的激动人心的时刻,它彻底改变了生物学的方方面面。本文首先综述了本课组对铜绿假单胞菌细胞毒素转化噬菌体的基因组分析以及对肠出血性大肠杆菌及其相关细菌的进化和基因组多样性的研究结果。我们对立克次体科家族基因组的分析结果,显示出令人惊讶的非常低的基因组多样性,以及基于基因组序列的医院内细菌爆发和宿主内基因组多样性分析也进行了总结。
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引用次数: 0
[Sponsor On-demand Presentation]. [赞助商点播演讲]。
Pub Date : 2022-01-01 DOI: 10.3412/jsb.77.117
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引用次数: 0
[Workshop]. (车间)。
Pub Date : 2022-01-01 DOI: 10.3412/jsb.77.37
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引用次数: 0
[ICD]. (ICD)。
Pub Date : 2022-01-01 DOI: 10.3412/jsb.77.118
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引用次数: 0
[Index]. (索引)。
Pub Date : 2022-01-01 DOI: 10.3412/jsb.77.120
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引用次数: 0
[Symposium]. (研讨会)。
Pub Date : 2022-01-01 DOI: 10.3412/jsb.77.17
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引用次数: 0
[Special Lecture]. [专题讲座]。
Pub Date : 2022-01-01 DOI: 10.3412/jsb.77.3
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引用次数: 0
期刊
Nihon saikingaku zasshi. Japanese journal of bacteriology
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