Z. A. Mazar, Sara Rahmati Roodsari, Zahra Mirabedyni, L. Haghighi, M. Rahimi
BackgroundEffective malaria control strategies require an accurate understanding of the epidemiology of locally transmitted Plasmodium species. Emerging evidence indicates that migrants from malaria endemic regions are at risk of delayed presentation of Plasmodium spp. and malaria infection. Cases ReportWe reported a case of P. vivax malaria occurring after arrival in Iran. Patient was originally from Iraq. A 48-year-old male patient who was hospitalized with fever attacks, chills, and headache after arriving from Iraq to Tehran.ConclusionIn this patient, new prevention and screening strategies should be studied and blood safety policies adapted. Thus, ultimate elimination of malaria in Iran will require national malaria control program to adopt policy and practice aimed at all human species of malaria since neighbor country are still face to problem to control of malaria.
{"title":"Imported Malaria in an Iraqi Immigrant to Iran: Relevance for the Maintenance of Elimination Status","authors":"Z. A. Mazar, Sara Rahmati Roodsari, Zahra Mirabedyni, L. Haghighi, M. Rahimi","doi":"10.22037/NBM.V1I1.27364","DOIUrl":"https://doi.org/10.22037/NBM.V1I1.27364","url":null,"abstract":"BackgroundEffective malaria control strategies require an accurate understanding of the epidemiology of locally transmitted Plasmodium species. Emerging evidence indicates that migrants from malaria endemic regions are at risk of delayed presentation of Plasmodium spp. and malaria infection. Cases ReportWe reported a case of P. vivax malaria occurring after arrival in Iran. Patient was originally from Iraq. A 48-year-old male patient who was hospitalized with fever attacks, chills, and headache after arriving from Iraq to Tehran.ConclusionIn this patient, new prevention and screening strategies should be studied and blood safety policies adapted. Thus, ultimate elimination of malaria in Iran will require national malaria control program to adopt policy and practice aimed at all human species of malaria since neighbor country are still face to problem to control of malaria.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"122 1","pages":"98-100"},"PeriodicalIF":0.0,"publicationDate":"2020-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79458789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Mohammadi, F. Hassani, S. Emamipour, F. Golshani
Background: The aim of this study was to compare the effectiveness of cognitive-behavioral therapy and acceptance-commitment based therapy in decreasing drug craving in women who were addicted to the crystal. Materials and Methods: The research method was quasi-experimental pre-test-post-test with the control group and two methods; the cognitive-behavioral, and the acceptance and commitment therapy were separately followed for two experimental groups with a follow-up phase. The statistical population of this study was all women who were addicted to the crystal that referred to addiction treatment centers in Isfahan province during the period of August to October 2017. They were simultaneously depressed. The instruments used in the study were the Wilson, Guilford and Concrete protocol (2004) that is the treatment based on the acceptance, Carole's cognitive-behavioral therapy (1998), and Frankl (2002) craving for drug questionnaire, as well as repeated measures of variance analysis. Results: Findings showed that cognitive-behavioral and acceptance and commitment therapies for craving of crystal usage are effective in women who have had crystal abuse. Between two methods of cognitive behavioral therapy, and acceptance and commitment therapy in the field of craving for the crystal in women that overcome drug addiction, there was a significant difference. The acceptance and commitment therapy had effects that are more therapeutic. Conclusion: Therefore, this study provides a total empirical support for acceptance-based and commitment treatment in the treatment of women who were overcoming the crystal addition.
背景:本研究的目的是比较认知-行为疗法和接受-承诺疗法在减少水晶成瘾妇女的药物渴望方面的效果。材料与方法:研究方法为准实验前测后测，采用对照组和两种方法;两个实验组分别进行认知行为治疗和接受承诺治疗，并进行随访。本研究的统计人群是2017年8月至10月期间在伊斯法罕省成瘾治疗中心就诊的所有对晶体成瘾的女性。他们同时感到沮丧。本研究使用的工具有Wilson, Guilford and Concrete protocol(2004)，即基于接受的治疗方法，Carole的认知行为疗法(1998)，Frankl(2002)的药物渴望问卷，以及重复测量方差分析。结果:研究结果表明，认知行为疗法和接受与承诺疗法对滥用水晶的妇女对水晶的渴望是有效的。在认知行为疗法和接受承诺疗法两种方法之间，对水晶的渴望在克服药物成瘾的女性中存在显著差异。接受和承诺疗法的效果更有治疗性。结论:本研究为接受型和承诺型治疗在克服晶体成瘾的女性治疗中提供了全面的实证支持。
{"title":"Comparison of the Effectiveness of Cognitive-Behavioral Therapy and Acceptance and Commitment Therapy in Reducing Craving in Women Consuming Crystal Drug","authors":"M. Mohammadi, F. Hassani, S. Emamipour, F. Golshani","doi":"10.22037/NBM.V1I1.25226","DOIUrl":"https://doi.org/10.22037/NBM.V1I1.25226","url":null,"abstract":"Background: The aim of this study was to compare the effectiveness of cognitive-behavioral therapy and acceptance-commitment based therapy in decreasing drug craving in women who were addicted to the crystal. \u0000Materials and Methods: The research method was quasi-experimental pre-test-post-test with the control group and two methods; the cognitive-behavioral, and the acceptance and commitment therapy were separately followed for two experimental groups with a follow-up phase. The statistical population of this study was all women who were addicted to the crystal that referred to addiction treatment centers in Isfahan province during the period of August to October 2017. They were simultaneously depressed. The instruments used in the study were the Wilson, Guilford and Concrete protocol (2004) that is the treatment based on the acceptance, Carole's cognitive-behavioral therapy (1998), and Frankl (2002) craving for drug questionnaire, as well as repeated measures of variance analysis. \u0000Results: Findings showed that cognitive-behavioral and acceptance and commitment therapies for craving of crystal usage are effective in women who have had crystal abuse. Between two methods of cognitive behavioral therapy, and acceptance and commitment therapy in the field of craving for the crystal in women that overcome drug addiction, there was a significant difference. The acceptance and commitment therapy had effects that are more therapeutic. \u0000Conclusion: Therefore, this study provides a total empirical support for acceptance-based and commitment treatment in the treatment of women who were overcoming the crystal addition.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"50 1","pages":"109-116"},"PeriodicalIF":0.0,"publicationDate":"2020-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76024635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Hashemi, Hossein Adlkhoo, Payman Dadkhah, Ramin Rohanifar, M. Taheri
Background: Knee osteoarthritis is a common disease associated with knee pain, physical disability, and joint stiffness. The use of non-surgical treatment methods in patients with knee osteoarthritis is important. Autologous conditioned serum (ACS) is a new regenerative therapeutic method that was investigated by a limited number of clinical trials. So far, using ACS in patients with Knee osteoarthritis remains to be controversial among physicians. Thus, the current study was carried out to compare the therapeutic effects of intra-articular ACS and ozone injections in patients with knee osteoarthritis. Materials and Methods: This prospective, double-blind randomized clinical trial was conducted among 60 patients (30= interleukin-1 receptor antagonist (IL-1Ra) group, 30= ozone group) with knee osteoarthritis, who referred to the Pain Management Clinic of Akhtar Educational Hospital during 2018 to 2019. In the IL-1Ra group, 2 ml of IL-1Ra was injected into the knee joint. The regimen protocol consisted of 4 injections, performed on the first, seventh, fourteenth, and twenty-first days of the treatment and ozone group, 10 ml of ozone (30 μg/ml) + 5 ml of lidocaine 1% were injected into the knee joint. The regimen protocol consisted of 3 injections, performed on the first day of the treatment, one month after the first injection, and two months after the first injection. The severity of pain was assessed by the patients’ self-report of pain and using the visual analog scale (VAS), before the treatment and 1, 3 and 6 months after the treatment. The Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaires were also measured at before and 6 months following treatment. Results: The changes in the VAS pain at different time periods showed statistically significant differences in the two groups, (P=0.0001). There was no significant difference between the two groups before the treatment and one month and three months after the initiation of the treatment; however, there was a significant difference between the two groups six months after the initiation of the treatment (P=0.0001). KOOS scores of symptoms, daily activities, and athletic and recreational functions were significantly higher in the IL-1Ra group, and the WOMAC scores of physical function and joint stiffness and the overall scores were significantly higher in the IL-1Ra group, (p<0.05). Conclusion: The intra-articular injection of IL-1Ra is a low-invasive, safe, effective, and long-acting method. In patients with knee osteoarthritis, clinical improvements and responses to the intra-articular IL-1Ra injection are better and longer compared to ozone injection. Therefore, it can be considered as a suitable choice in treating patients with chronic knee pain.
背景:膝关节骨关节炎是一种常见疾病，与膝关节疼痛、身体残疾和关节僵硬有关。采用非手术治疗方法治疗膝骨关节炎是很重要的。自体条件血清(ACS)是一种新的再生治疗方法，目前已被有限的临床试验所探索。到目前为止，在膝关节骨性关节炎患者中使用ACS在医生中仍然存在争议。因此，本研究比较了关节内ACS和臭氧注射对膝关节骨关节炎患者的治疗效果。材料与方法:本前瞻性、双盲随机临床试验选取2018 - 2019年在阿赫塔尔教育医院疼痛管理门诊就诊的60例膝关节骨性关节炎患者(白介素-1受体拮抗剂(IL-1Ra)组30例，臭氧组30例)。IL-1Ra组膝关节内注射IL-1Ra 2ml。方案分为4次注射，分别于治疗第1、7、14、21天进行。臭氧组，膝关节内注射臭氧(30 μg/ml) 10 ml + 1%利多卡因5 ml。方案包括3次注射，分别在治疗第一天、第一次注射后1个月和第一次注射后2个月进行。治疗前、治疗后1个月、3个月和6个月分别采用患者疼痛自述和视觉模拟量表(VAS)评估疼痛程度。在治疗前和治疗后6个月测量膝关节损伤和骨关节炎结局评分(oos)以及西安大略大学和麦克马斯特大学骨关节炎指数(WOMAC)问卷。结果:两组VAS疼痛在不同时间段的变化差异有统计学意义(P=0.0001)。两组在治疗前、治疗开始后1个月、3个月无显著差异;然而，在治疗开始6个月后，两组之间存在显著差异(P=0.0001)。IL-1Ra组患者症状、日常活动、运动和娱乐功能的oos评分显著高于对照组，IL-1Ra组患者躯体功能、关节刚度的WOMAC评分及总分显著高于对照组，差异均有统计学意义(p<0.05)。结论:关节内注射IL-1Ra是一种低创、安全、有效、长效的方法。在膝关节骨性关节炎患者中，与臭氧注射相比，关节内注射IL-1Ra的临床改善和反应时间更长。因此，它可以被认为是治疗慢性膝关节疼痛患者的合适选择。
{"title":"A comparative assessment of Autologous conditioned serum and ozone for knee osteoarthritis treatment: mid-term follow up","authors":"M. Hashemi, Hossein Adlkhoo, Payman Dadkhah, Ramin Rohanifar, M. Taheri","doi":"10.22037/NBM.V1I1.25891","DOIUrl":"https://doi.org/10.22037/NBM.V1I1.25891","url":null,"abstract":"Background: Knee osteoarthritis is a common disease associated with knee pain, physical disability, and joint stiffness. The use of non-surgical treatment methods in patients with knee osteoarthritis is important. Autologous conditioned serum (ACS) is a new regenerative therapeutic method that was investigated by a limited number of clinical trials. So far, using ACS in patients with Knee osteoarthritis remains to be controversial among physicians. Thus, the current study was carried out to compare the therapeutic effects of intra-articular ACS and ozone injections in patients with knee osteoarthritis. Materials and Methods: This prospective, double-blind randomized clinical trial was conducted among 60 patients (30= interleukin-1 receptor antagonist (IL-1Ra) group, 30= ozone group) with knee osteoarthritis, who referred to the Pain Management Clinic of Akhtar Educational Hospital during 2018 to 2019. In the IL-1Ra group, 2 ml of IL-1Ra was injected into the knee joint. The regimen protocol consisted of 4 injections, performed on the first, seventh, fourteenth, and twenty-first days of the treatment and ozone group, 10 ml of ozone (30 μg/ml) + 5 ml of lidocaine 1% were injected into the knee joint. The regimen protocol consisted of 3 injections, performed on the first day of the treatment, one month after the first injection, and two months after the first injection. The severity of pain was assessed by the patients’ self-report of pain and using the visual analog scale (VAS), before the treatment and 1, 3 and 6 months after the treatment. The Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaires were also measured at before and 6 months following treatment. Results: The changes in the VAS pain at different time periods showed statistically significant differences in the two groups, (P=0.0001). There was no significant difference between the two groups before the treatment and one month and three months after the initiation of the treatment; however, there was a significant difference between the two groups six months after the initiation of the treatment (P=0.0001). KOOS scores of symptoms, daily activities, and athletic and recreational functions were significantly higher in the IL-1Ra group, and the WOMAC scores of physical function and joint stiffness and the overall scores were significantly higher in the IL-1Ra group, (p<0.05). Conclusion: The intra-articular injection of IL-1Ra is a low-invasive, safe, effective, and long-acting method. In patients with knee osteoarthritis, clinical improvements and responses to the intra-articular IL-1Ra injection are better and longer compared to ozone injection. Therefore, it can be considered as a suitable choice in treating patients with chronic knee pain.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"40 1","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"2020-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85439377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Gholami, S. Kalbasi, M. Sheibani, Z. Davoudi, Roxana Sadeghi, Fatima Meeckunickee, Mina Nikpoor, Hesamedin Gordan
Background: Hypothyroidism is a cause of left ventricular diastolic dysfunction especially in cases with positive history of coronary artery disease. It is suggested that cardiac dysfunction may be improved with thyroxin replacement therapy. However, it is controversial. Hence, in this study the efficacy of levothyroxine therapy on diastolic dysfunction in patients with subclinical hypothyroidism was assessed. Materials and Methods: In this, randomized clinical trial 40 consecutive patients with subclinical hypothyroidism attending to Loghman Hospital in 2018 for the treatment were enrolled. The treatment was 25-50 microgram per day of levothyroxine for one year. During this period, the patients were followed up with visit or phone call with a monthly manner. The echocardiography indices were rechecked after one year beside the thyroid tests by initial lab and operators. Results: The mean BMI was significantly decreased (P=0.001). The T3 and TSH were significantly differed but The T4 had no significant alteration (P>0.05). Among the echocardiographic indices the MV.E, MV.A to MV. E ratio, EF, Eʹ septal, Eʹ lateral had significant increase and the MV.A and PV. Adur had significant reduction. After intervention among 40 patients, there were 17 cases with normal diastolic function. The BMI, MV. A, PV Adur, Eʹ Septal, Eʹ Lateral, and E to Eʹ ratio showed significant correlation. Conclusion: Totally, according to the obtained results, it is concluded that diastolic dysfunction as a common problem in patients with subclinical hypothyroidism may be treated with administration of levothyroxine. In addition, screening for diastolic dysfunction in patients with subclinical hypothyroidism is recommended to decrease the burden of problem.
背景:甲状腺功能减退是左室舒张功能障碍的一个原因，特别是在有冠状动脉疾病病史的患者中。提示甲状腺素替代治疗可改善心功能障碍。然而，这是有争议的。因此，本研究评估了左旋甲状腺素治疗亚临床甲状腺功能减退患者舒张功能障碍的疗效。材料与方法:本随机临床试验纳入2018年在Loghman医院连续就诊的40例亚临床甲状腺功能减退患者。治疗是每天25-50微克左甲状腺素，持续一年。在此期间，对患者进行每月一次的访视或电话随访。术后1年复查超声心动图指标，除甲状腺检查外，由初始实验室和手术人员复查。结果:平均BMI明显降低(P=0.001)。T3、TSH差异有统计学意义，T4无显著性变化(P>0.05)。超声心动图指标中MV。E, MV。A到MV。E比、EF、E间隔、E外侧显著增高，MV显著增高。A和PV。阿杜尔有明显的减少。40例患者经干预后舒张功能正常17例。BMI, MV。A、PV - Adur、E - Septal、E - Lateral、E - to - E - ratio呈显著相关。结论:总的来说，根据所获得的结果，舒张功能障碍是亚临床甲状腺功能减退患者的常见问题，左旋甲状腺素可以治疗舒张功能障碍。此外，亚临床甲状腺功能减退症患者的舒张功能障碍筛查建议减少问题的负担。
{"title":"Efficacy of Levothyroxine Therapy on Diastolic Dysfunction in Patients with Subclinical Hypothyroidism","authors":"R. Gholami, S. Kalbasi, M. Sheibani, Z. Davoudi, Roxana Sadeghi, Fatima Meeckunickee, Mina Nikpoor, Hesamedin Gordan","doi":"10.22037/NBM.V8I1.25379","DOIUrl":"https://doi.org/10.22037/NBM.V8I1.25379","url":null,"abstract":"Background: Hypothyroidism is a cause of left ventricular diastolic dysfunction especially in cases with positive history of coronary artery disease. It is suggested that cardiac dysfunction may be improved with thyroxin replacement therapy. However, it is controversial. Hence, in this study the efficacy of levothyroxine therapy on diastolic dysfunction in patients with subclinical hypothyroidism was assessed. Materials and Methods: In this, randomized clinical trial 40 consecutive patients with subclinical hypothyroidism attending to Loghman Hospital in 2018 for the treatment were enrolled. The treatment was 25-50 microgram per day of levothyroxine for one year. During this period, the patients were followed up with visit or phone call with a monthly manner. The echocardiography indices were rechecked after one year beside the thyroid tests by initial lab and operators. Results: The mean BMI was significantly decreased (P=0.001). The T3 and TSH were significantly differed but The T4 had no significant alteration (P>0.05). Among the echocardiographic indices the MV.E, MV.A to MV. E ratio, EF, Eʹ septal, Eʹ lateral had significant increase and the MV.A and PV. Adur had significant reduction. After intervention among 40 patients, there were 17 cases with normal diastolic function. The BMI, MV. A, PV Adur, Eʹ Septal, Eʹ Lateral, and E to Eʹ ratio showed significant correlation. Conclusion: Totally, according to the obtained results, it is concluded that diastolic dysfunction as a common problem in patients with subclinical hypothyroidism may be treated with administration of levothyroxine. In addition, screening for diastolic dysfunction in patients with subclinical hypothyroidism is recommended to decrease the burden of problem.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"414 1","pages":"31-35"},"PeriodicalIF":0.0,"publicationDate":"2020-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84891644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Various strategies have been proposed to minimize reperfusion delay in patients who are candidate for primary percutaneous coronary intervention (PCI). Reperfusion time may be affected by both intra- and extra-hospital factors. The study attempted to identify factors affecting reperfusion time to reduce mortality and morbidity. Materials and Methods: In this cross-sectional study, 95 patients with chest pain who were admitted to a hospital emergency in Tehran (capital city of Iran) were admitted and those who were diagnosed with ST-segment elevation myocardial infarction (STEMI) were candidates for primary PCI. Basic information was asked from the patients or companion of them. In addition, the PCI time recorded in the patient file was entered in the checklist. Results: The mean interval between the onset of symptoms and primary PCI was 218.6±21.69 min. The interval between the first medical contact (FMC) and primary PCI was determined to be 87.122±183.66 minutes. The mean time of door to balloon in the hospital was 42.49±78.53 min. In addition, the mean time interval from symptom onset to FMC was 19.47±11.84 minutes. In 31 cases (32.6%), the emergency service (EMS) contacted. Three factors were identified to be associated with a delay between the onset of symptoms to primary PCI (or delay reperfusion time) including the previous history of myocardial infarction (MI) (p=0.034), the severity of coronary artery disease, based on angiography (p=0.043) and the type of vehicle used to transfer the patient to the hospital (p=0.007). Conclusion: The reperfusion delay seems to be higher in our treatment center than in other centers. Three preceding factors of MI, the severity of coronary artery disease and the transmission of patients via EMS are considered factors associated with the reduction of reperfusion delay.
{"title":"Reperfusion Delay and its Main Correlates in Patients with ST-Segment Elevation Myocardial Infarction under Primary PCI","authors":"A. Sadrzadeh","doi":"10.22037/NBM.V7I2.22831","DOIUrl":"https://doi.org/10.22037/NBM.V7I2.22831","url":null,"abstract":"Background: Various strategies have been proposed to minimize reperfusion delay in patients who are candidate for primary percutaneous coronary intervention (PCI). Reperfusion time may be affected by both intra- and extra-hospital factors. The study attempted to identify factors affecting reperfusion time to reduce mortality and morbidity. Materials and Methods: In this cross-sectional study, 95 patients with chest pain who were admitted to a hospital emergency in Tehran (capital city of Iran) were admitted and those who were diagnosed with ST-segment elevation myocardial infarction (STEMI) were candidates for primary PCI. Basic information was asked from the patients or companion of them. In addition, the PCI time recorded in the patient file was entered in the checklist. Results: The mean interval between the onset of symptoms and primary PCI was 218.6±21.69 min. The interval between the first medical contact (FMC) and primary PCI was determined to be 87.122±183.66 minutes. The mean time of door to balloon in the hospital was 42.49±78.53 min. In addition, the mean time interval from symptom onset to FMC was 19.47±11.84 minutes. In 31 cases (32.6%), the emergency service (EMS) contacted. Three factors were identified to be associated with a delay between the onset of symptoms to primary PCI (or delay reperfusion time) including the previous history of myocardial infarction (MI) (p=0.034), the severity of coronary artery disease, based on angiography (p=0.043) and the type of vehicle used to transfer the patient to the hospital (p=0.007). Conclusion: The reperfusion delay seems to be higher in our treatment center than in other centers. Three preceding factors of MI, the severity of coronary artery disease and the transmission of patients via EMS are considered factors associated with the reduction of reperfusion delay.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"12 1","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"2020-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87579036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Pneumococcal vaccines are recommended in patients with immune deficiencies such as kidney transplant recipients and dialysis subjects. Streptococcus pneumoniae is an agent of pneumonia, meningitis, important morbidities and mortality in such patients. The purpose of this study was to evaluate and compare the antibody responses in hemodialysis patients, peritoneal dialysis, kidney transplant recipients and normal subjects after administration of 23-valent pneumococcal polysaccharide vaccine (PPV23). Materials and Methods: The present randomized clinical trial was conducted on 162 subjects including 57 hemodialysis patients, 29 peritoneal dialysis patients, 48 kidney transplant recipients, and 28 healthy controls. The participants received a single-dose pneumococcal vaccine (Pneumovax 23) of 0.5 ml in the upper limb muscle. The efficacy of vaccination was evaluated by measuring the antibody response to the entire vaccine. Serum samples were collected before, one and six months after vaccination. Results: The levels of IgG pneumococcal antibodies at pre-vaccination periods, one and six months after vaccination were 11.6±1.52 IU/ml, 14.98±1.98 IU/ml and 14.87±0.66 IU/ml in kidney transplant recipients, 12.03±1.93 IU/ml, 15.26±0.49 IU/ml and 14.3±0.72 IU/ml in hemodialysis patients, and 11.5±1.55 IU/ml, 15.2±1.81 IU/ml, and 14.2±1.7 IU/ml, respectively. The serum antibody level was significantly higher in kidney transplant recipients than in both dialysis groups after six months of vaccination (p=0.029). Conclusion: We found that patients with renal failure respond to pneumococcal vaccination in hemodialysis and kidney transplantation. However, they lost their serum antibodies within six months of vaccination. Determining the protective level for serum IGG and IGG2 in these patients helps us to follow up on these patients more precisely in order to re-vaccinate when the protective level of serum antibody is broken.
{"title":"Evaluation of Antibody Responses in Hemodialysis Patients, Peritoneal Dialysis, Kidney Transplant Recipients and Normal Subjects after Administration of 23-Valent Pneumococcal Polysaccharide Vaccine","authors":"H. Argani, Ali Rostamiasl","doi":"10.22037/NBM.V8I1.25832","DOIUrl":"https://doi.org/10.22037/NBM.V8I1.25832","url":null,"abstract":"Background: Pneumococcal vaccines are recommended in patients with immune deficiencies such as kidney transplant recipients and dialysis subjects. Streptococcus pneumoniae is an agent of pneumonia, meningitis, important morbidities and mortality in such patients. The purpose of this study was to evaluate and compare the antibody responses in hemodialysis patients, peritoneal dialysis, kidney transplant recipients and normal subjects after administration of 23-valent pneumococcal polysaccharide vaccine (PPV23). Materials and Methods: The present randomized clinical trial was conducted on 162 subjects including 57 hemodialysis patients, 29 peritoneal dialysis patients, 48 kidney transplant recipients, and 28 healthy controls. The participants received a single-dose pneumococcal vaccine (Pneumovax 23) of 0.5 ml in the upper limb muscle. The efficacy of vaccination was evaluated by measuring the antibody response to the entire vaccine. Serum samples were collected before, one and six months after vaccination. Results: The levels of IgG pneumococcal antibodies at pre-vaccination periods, one and six months after vaccination were 11.6±1.52 IU/ml, 14.98±1.98 IU/ml and 14.87±0.66 IU/ml in kidney transplant recipients, 12.03±1.93 IU/ml, 15.26±0.49 IU/ml and 14.3±0.72 IU/ml in hemodialysis patients, and 11.5±1.55 IU/ml, 15.2±1.81 IU/ml, and 14.2±1.7 IU/ml, respectively. The serum antibody level was significantly higher in kidney transplant recipients than in both dialysis groups after six months of vaccination (p=0.029). Conclusion: We found that patients with renal failure respond to pneumococcal vaccination in hemodialysis and kidney transplantation. However, they lost their serum antibodies within six months of vaccination. Determining the protective level for serum IGG and IGG2 in these patients helps us to follow up on these patients more precisely in order to re-vaccinate when the protective level of serum antibody is broken.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"91 1","pages":"36-44"},"PeriodicalIF":0.0,"publicationDate":"2020-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86243148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Mostafazadeh, F. Najari, M. Emamhadi, ghasem ghaedi
Background: Increasing the number of complaints against medical staff emphasizes the need for physicians to be more familiar with legal issues before and during providing medical services to the patient. Signing the informed consent form before medical practices and informing the patient of all possible outcomes can cause mental health and better collaboration of patients as well as increase the physician's self-confidence to provide better services. The current study aimed at determining the status of standard informed consent in medical cases related to different surgical fields referring to Tehran's Commission of Forensic Medicine during the first quarter of 2017. Materials and Methods: In the current descriptive, cross-sectional study, the cases of medical malpractice related to different surgical fields referring to Tehran's Commission of Forensic Medicine in the first quarter of 2017 were investigated. Data were analyzed with SPSS version 16. Results: In the current study, 124 cases of complaints against the medical staff of the surgical fields were examined. Based on the obtained data, the age and specialty of physicians, faculty status, and type of treatment center were effective in obtaining standard informed consent, and the highest percentage of allegations against the charge was related to cases attempted to obtain informed consent. Conclusion: Obtaining the standard consent can significantly improve the patient-physician relationships and reduce the rate of medical malpractice complaints.
背景:针对医务人员的投诉越来越多，这凸显了医生在向患者提供医疗服务之前和过程中更熟悉法律问题的必要性。在医疗实践之前签署知情同意书，并告知患者所有可能的结果，可促进精神健康，改善患者之间的合作，并增强医生提供更好服务的信心。目前的研究旨在确定2017年第一季度参考德黑兰法医委员会与不同外科领域相关的医疗病例中标准知情同意的状况。材料与方法:在目前的描述性横断面研究中，对2017年第一季度德黑兰法医委员会涉及不同外科领域的医疗事故进行了调查。数据采用SPSS version 16进行分析。结果:本研究共调查了124例对外科医务人员的投诉。根据获得的数据，医生的年龄和专业、教师地位和治疗中心的类型在获得标准知情同意方面是有效的，针对该指控的最高比例的指控与试图获得知情同意的案件有关。结论:获得标准同意可显著改善医患关系，降低医疗事故投诉率。
{"title":"Assessing informed consent in medical malpractice cases associated with different surgical fields referring to Tehran's Commission of Forensic Medicine, 2017","authors":"B. Mostafazadeh, F. Najari, M. Emamhadi, ghasem ghaedi","doi":"10.22037/NBM.V8I1.26635","DOIUrl":"https://doi.org/10.22037/NBM.V8I1.26635","url":null,"abstract":"Background: Increasing the number of complaints against medical staff emphasizes the need for physicians to be more familiar with legal issues before and during providing medical services to the patient. Signing the informed consent form before medical practices and informing the patient of all possible outcomes can cause mental health and better collaboration of patients as well as increase the physician's self-confidence to provide better services. The current study aimed at determining the status of standard informed consent in medical cases related to different surgical fields referring to Tehran's Commission of Forensic Medicine during the first quarter of 2017. Materials and Methods: In the current descriptive, cross-sectional study, the cases of medical malpractice related to different surgical fields referring to Tehran's Commission of Forensic Medicine in the first quarter of 2017 were investigated. Data were analyzed with SPSS version 16. Results: In the current study, 124 cases of complaints against the medical staff of the surgical fields were examined. Based on the obtained data, the age and specialty of physicians, faculty status, and type of treatment center were effective in obtaining standard informed consent, and the highest percentage of allegations against the charge was related to cases attempted to obtain informed consent. Conclusion: Obtaining the standard consent can significantly improve the patient-physician relationships and reduce the rate of medical malpractice complaints.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"2014 1","pages":"53-57"},"PeriodicalIF":0.0,"publicationDate":"2020-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73812326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Khorasanizadeh, M. Panahi, Gholamreza Mohseni, F. Behnaz, Masih Ebrahymy Dehkordy, Houman Teymourian
Background: The purpose of this study was to compare the effect of analgesia of Ropivacaine and magnesium sulfate as subcutaneous infiltration at the site of surgical cutaneous cholecystectomy in the postoperative period. Materials and Methods: To achieve the research goals, 80 patients referred to Shohada Tajrish Hospital in Tehran in 2016, which were randomly divided into two groups: Ropivacaine and magnesium sulfate. Patients in both groups had similar anesthetic procedures and all of them were monitored standard were recorded within 24 hours of operation. Overall morphine dose was also recorded for postoperative pain. Results: The findings showed that there was a significant difference between the two groups in the Ropivacaine group in the next hours despite the no significant difference in age, sex, BMI, duration of operation and pain scoring at first and third hours. In addition, the comparison of the number of requests for at least one dose of morphine in the Ropivacaine group is significantly lower. In addition, the comparison of the number of requests for at least one dose of morphine in the Ropivacaine group is significantly lower. The occurrence of PONV is also higher in the magnesium sulfate group, but this difference is not significant. Conclusion: Local injection of Ropivacaine reduced acute pain after open cholecystectomy surgery in comparison to local injection of magnesium sulfate. In addition, the use of Ropivacaine is associated with a significant reduction in the need for intravenous morphine for analgesia.
{"title":"Comparison of Analgesia in Subcutaneous Infiltration of Ropivacaine and Magnesium Sulfate for Postoperative Pain Control of Cholecystectomy","authors":"S. Khorasanizadeh, M. Panahi, Gholamreza Mohseni, F. Behnaz, Masih Ebrahymy Dehkordy, Houman Teymourian","doi":"10.22037/NBM.V7I4.25686","DOIUrl":"https://doi.org/10.22037/NBM.V7I4.25686","url":null,"abstract":"Background: The purpose of this study was to compare the effect of analgesia of Ropivacaine and magnesium sulfate as subcutaneous infiltration at the site of surgical cutaneous cholecystectomy in the postoperative period. Materials and Methods: To achieve the research goals, 80 patients referred to Shohada Tajrish Hospital in Tehran in 2016, which were randomly divided into two groups: Ropivacaine and magnesium sulfate. Patients in both groups had similar anesthetic procedures and all of them were monitored standard were recorded within 24 hours of operation. Overall morphine dose was also recorded for postoperative pain. Results: The findings showed that there was a significant difference between the two groups in the Ropivacaine group in the next hours despite the no significant difference in age, sex, BMI, duration of operation and pain scoring at first and third hours. In addition, the comparison of the number of requests for at least one dose of morphine in the Ropivacaine group is significantly lower. In addition, the comparison of the number of requests for at least one dose of morphine in the Ropivacaine group is significantly lower. The occurrence of PONV is also higher in the magnesium sulfate group, but this difference is not significant. Conclusion: Local injection of Ropivacaine reduced acute pain after open cholecystectomy surgery in comparison to local injection of magnesium sulfate. In addition, the use of Ropivacaine is associated with a significant reduction in the need for intravenous morphine for analgesia.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"84 1","pages":"13-19"},"PeriodicalIF":0.0,"publicationDate":"2020-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85380727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hadi Saberpour, Seyyed Amir Sheikholeslami, Meghdad Sedaghat, M. Mahjoob
Background: Recognition of association between anemia and new onset atrial fibrillation would result in better therapeutic approaches and better prognosis. Hence, the purpose was to determine the prevalence of anemia and new onset atrial fibrillation (AF) in patient come to Imam Hossein hospital emergency department. Materials and Methods: In the observational study that performed as a case-control survey, 150 consecutive addicted patients in imam hossein hospital emergency department in 2018 were enrolled including those with and without AF in electrocardiogram (EKG) and the frequency rate of anemia among groups was determined and compared. Results: The results in this study demonstrated that 43 patients (27.8%) had anemia that was seen in 36% and 21.3% in case and control groups, respectively with statistically significant difference (p=0.047). Conclusion: Totally, according to the obtained results there was significant association between anemia and new onset atrial fibrillation.
{"title":"Prevalence of anemia and new onset atrial fibrillation in patient come to imam hossein hospital emergency department","authors":"Hadi Saberpour, Seyyed Amir Sheikholeslami, Meghdad Sedaghat, M. Mahjoob","doi":"10.22037/NBM.V7I4.25317","DOIUrl":"https://doi.org/10.22037/NBM.V7I4.25317","url":null,"abstract":"Background: Recognition of association between anemia and new onset atrial fibrillation would result in better therapeutic approaches and better prognosis. Hence, the purpose was to determine the prevalence of anemia and new onset atrial fibrillation (AF) in patient come to Imam Hossein hospital emergency department. Materials and Methods: In the observational study that performed as a case-control survey, 150 consecutive addicted patients in imam hossein hospital emergency department in 2018 were enrolled including those with and without AF in electrocardiogram (EKG) and the frequency rate of anemia among groups was determined and compared. Results: The results in this study demonstrated that 43 patients (27.8%) had anemia that was seen in 36% and 21.3% in case and control groups, respectively with statistically significant difference (p=0.047). Conclusion: Totally, according to the obtained results there was significant association between anemia and new onset atrial fibrillation.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"173 1","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2020-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73765223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Aichivirus as a new member of Picornaviridae family was detected and isolated in Japan. Aichivirus species, which belongs to genus Kobuvirus, include of three genotypes A, B and C. Based on previous reports to detect aichiviruses in stool samples as well as environmental samples such as river waters and sewage waters, it has been demonstrated that Aichivirus infect humans by fecal-oral routs. In order to establish an examination for the prevalence of Aichivirus among pediatric patients involved to acute gastroenteritis, we conducted a RT-qPCR assay for detection and quantification of Aichivirus in collected stool samples. Materials and Methods: In this study, a total of 160 stool samples from September 2018 to May 2019 were collected from presenting pediatric patients with acute gastroenteritis in Karaj hospital, Iran. After viral RNA extraction, the RT-PCR was performed to amplify the 3CD junction region of Aichivirus. Results: Out of the 160 samples tested, the Aichivirus genomic RNA was detected in 13/160 (8.1%) of stool samples. The maximum viral prevalence rate was related to December (30.7%). The co-infection of Aichivirus with Salivirus and Saffold virus also assessed, among which high double or triple mixed-infections were determined. Conclusion: This is the first documentation of Aichivirus detection in stool samples that demonstrates Aichivirus has been circulating among Iranian pediatric patients. Our results indicate that Aichivirus in association with Salivirus and Saffold virus may be considered as a causative agent of acute gastroenteritis.
{"title":"First Molecular Detection of Aichivirus in Pediatric Patients with Acute Gastroenteritis in Iran","authors":"M. Taghinejad, M. Ghaderi, S. D. M. Nasab","doi":"10.22037/NBM.V7I4.26729","DOIUrl":"https://doi.org/10.22037/NBM.V7I4.26729","url":null,"abstract":"Background: Aichivirus as a new member of Picornaviridae family was detected and isolated in Japan. Aichivirus species, which belongs to genus Kobuvirus, include of three genotypes A, B and C. Based on previous reports to detect aichiviruses in stool samples as well as environmental samples such as river waters and sewage waters, it has been demonstrated that Aichivirus infect humans by fecal-oral routs. In order to establish an examination for the prevalence of Aichivirus among pediatric patients involved to acute gastroenteritis, we conducted a RT-qPCR assay for detection and quantification of Aichivirus in collected stool samples. Materials and Methods: In this study, a total of 160 stool samples from September 2018 to May 2019 were collected from presenting pediatric patients with acute gastroenteritis in Karaj hospital, Iran. After viral RNA extraction, the RT-PCR was performed to amplify the 3CD junction region of Aichivirus. Results: Out of the 160 samples tested, the Aichivirus genomic RNA was detected in 13/160 (8.1%) of stool samples. The maximum viral prevalence rate was related to December (30.7%). The co-infection of Aichivirus with Salivirus and Saffold virus also assessed, among which high double or triple mixed-infections were determined. Conclusion: This is the first documentation of Aichivirus detection in stool samples that demonstrates Aichivirus has been circulating among Iranian pediatric patients. Our results indicate that Aichivirus in association with Salivirus and Saffold virus may be considered as a causative agent of acute gastroenteritis.","PeriodicalId":19372,"journal":{"name":"Novelty in Biomedicine","volume":"81 1","pages":"20-25"},"PeriodicalIF":0.0,"publicationDate":"2020-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91182847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：