Nuclear Medicine and Molecular Imaging最新文献

Beta-thalassemia is an inherited blood disorder caused by reduced or absent synthesis of the beta chains of hemoglobin, resulting in decreased hemoglobin production. Symptoms depend on the type of beta-thalassemia ranging from no symptoms to severe illness. Ineffective erythropoiesis leads to a sequence of events responsible for bone marrow expansion, anemia, hemolysis, splenomegaly, increased iron absorption, and sometimes extramedullary hematopoiesis (EMH). We report an interesting case with EMH visualized on FDG-PET/CT and where FDG-PET/CT has also found the focus of a severe infection in a patient with beta-thalassemia.

Neuroendocrine tumors (NETs) originate from the neuroendocrine cells, which are found in various organs. NETs occur frequently in the gastrointestinal tract. NETs arising from tailgut cysts are uncommon. We herein report an interesting case of metastatic tailgut cyst NET, which was firstly diagnosed as plasmacytoma.

Purpose: We compared the feasibility of quantitative analysis methods using bone SPECT/CT with those using planar bone scans to assess active sacroiliitis.

Methods: We retrospectively reviewed whole-body bone scans and pelvic bone SPECT/CTs of 8 patients who had clinically confirmed sacroiliitis and enrolled 24 patients without sacroiliitis as references. The volume of interest of each sacroiliac joint, including both the ilium and sacrum, was drawn. Active arthritis zone (AAZ) was defined as the zone of voxels with higher SUV than sacral mean SUV within the VOI of SI joint. Then, the following SPECT/CT quantitative parameters, SUVmax (maximum SUV), SUV50% (mean SUV in highest 50% of SUV), and SUV-AAZ, and the ratio of those values to sacral mean SUV (SUVmax/S, SUV50%/S, SUV-AAZ/S) were calculated. For the planar bone scan, the mean count ratio of SI joint/sacrum (SI/S) was conventionally measured.

Results: Most of the SPECT/CT parameters of the sacroiliitis group were significantly higher than the normal group, whereas SI/S of the planar bone scan was not significantly different between the two groups. In receiver operating characteristic curve analysis, SUV-AAZ/S showed the highest AUC of 0.992, followed by SUV50%/S and SUVmax/S. All ratio parameters of the SPECT/CT showed higher AUC values than the SUV parameters of SI joint or SI/S of the planar scan.

Conclusions: The quantitative analyses of bone SPECT/CT showed better performance in assessing active sacroiliitis than the planar bone scan. SPECT/CT parameters using the ratio of the SI joint to sacrum showed more favorable results than SUV parameters such as SUVmax, SUV50%, and SUV-AAZ.

Purpose: To investigate the predictors of contralateral hypertrophy in patients treated with unilobar transarterial radioembolization (TARE) with yttrium-90-loaded resin microspheres due to unresectable right-liver tumors.

Methods: Patients who underwent right unilobar TARE with resin microspheres between May 2019 and September 2021 were screened retrospectively. Contralateral hypertrophy was evaluated by calculating the kinetic growth rate (KGR) in 8-10 weeks after TARE. The predictors of increased KGR were determined with linear regression analysis.

Results: A total of 24 patients (16 with primary and 8 with metastatic liver tumors) were included in the study. After right unilobar TARE, mean volume of the left lobe increased from 368.26 to 436.16 mL, while the mean volume of the right lobe decreased from 1576.22 to 1477.89 mL. The median KGR of the left lobe was 0.28% per week. The radiation dose absorbed by the healthy parenchyma of the right lobe was significantly higher in patients with increased KGR (31.62 vs. 18.78 Gy, p = 0.037). Linear regression analysis showed that the dose absorbed by healthy parenchyma was significantly associated with increased KGR (b = 0.014, p = 0.043).

Conclusion: Patients who received right unilobar TARE for liver malignancies could develop a substantial contralateral hypertrophy, and the radiation dose absorbed by the healthy parenchyma of the right lobe was significantly associated with increased KGR in the left lobe. TARE could have a role for inducing contralateral hypertrophy as it offers the advantage of concurrent local tumor control along with its hypertrophic effect.

Prostate-specific membrane antigen (PSMA) is highly expressed in PCa, which gradually increases in high-grade tumors, metastatic tumors, and tumors nonresponsive to androgen deprivation therapy. PSMA has been a topic of interest during the past decade for both diagnostic and therapeutic targets. Radioligand therapy (RLT) utilizes the delivery of radioactive nuclides to tumors and tumor-associated targets, and it has shown better efficacy with minimal toxicity compared to other systemic cancer therapies. Nuclear medicine has faced a new turning point claiming theranosis as the core of academic identity, since new RLTs have been introduced to clinics through the official new drug development processes for approval from the Food and Drug Administration (FDA) or European Medical Agency. Recently, PSMA targeting RLT was approved by the US FDA in March 2022. This review introduces PSMA RLT focusing on ongoing clinical trials to enhance our understanding of nuclear medicine theranosis and strive for the development of new radiopharmaceuticals.

Purpose: [¹⁷⁷Lu]Lu-DOTATATE and [¹⁷⁷Lu]Lu-PSMA-617 used for targeted radionuclide therapy are very often prepared in the hospital radiopharmacy. The preparation parameters vary depending upon the specific activity of the ¹⁷⁷Lu used. The aim of this study was to develop optimized protocols to be used in the nuclear medicine department for the preparation of patient doses of the above radiopharmaceuticals.

Method: ¹⁷⁷Lu (CA and NCA) were used for radiolabeling DOTATATE and PSMA-617. Parameters studied are ¹⁷⁷Lu of different specific activity and different peptide concentrations and two different buffer systems. Paper and thin layer chromatography systems were used for estimating the radiochemical yield as well as radiochemical purity. Solid-phase extraction was used for the purification of the labeled tracers.

Results: [¹⁷⁷Lu]Lu-DOTATATE was prepared with CA ¹⁷⁷Lu (n = 13) and NCA¹⁷⁷Lu (n = 6). Four batches each of [¹⁷⁷Lu]Lu-PSMA-617 were prepared using CA and NCA ¹⁷⁷Lu. Radiochemical yields > 80% and final product with less than < 1% radiochemical impurity could be obtained in all batches which were used for therapy.

Conclusion: Robust protocols for the preparation of clinical doses of [¹⁷⁷Lu]Lu-DOTATATE and [¹⁷⁷Lu]Lu-PSMA-617 were developed and used for the preparation of clinical doses. The quality of the SPECT images of both the tracers are consistent with the expected uptake in respective diseases.

Purpose: We aimed to investigate the incidence and clinical significance of incidental focal nasopharyngeal uptake on [¹⁸F]FDG PET/CT and to evaluate the diagnostic performance of various metabolic parameters to differentiate between benign and malignant nasopharyngeal lesions.

Methods: A total of 63 consecutive patients with incidental focal nasopharyngeal uptake on [¹⁸F]FDG PET/CT and subsequent nasopharyngeal biopsy were retrospectively enrolled. In addition, baseline pretherapeutic [¹⁸F]FDG PET/CT images of 59 patients with newly diagnosed pathologically proven nasopharyngeal carcinoma (NPC) were reviewed. Maximum standardized uptake value (SUVmax), mean SUV (SUVmean), nasopharynx-to-palatine tonsil ratio (NPR), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the nasopharyngeal lesions were determined. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic performance of the metabolic parameters.

Results: Incidental focal nasopharyngeal uptake in two patients (3.2%, 2/63) was pathologically confirmed to be NPC. All the metabolic parameters (SUVmax, SUVmean, NPR, MTV, and TLG) demonstrated significantly greater values in patients with NPC compared with patients with benign or physiological nasopharyngeal uptake (p < 0.001). Among the metabolic parameters, NPR demonstrated the greatest area under the curve of 0.992 (p < 0.05), with a sensitivity of 96.7% and a specificity of 93.4% when a cut-off of 1.1 was used. Similar results were seen in nasopharyngeal lesions without morphological abnormality.

Conclusion: NPC is an infrequent but important cause of incidental focal nasopharyngeal uptake on [¹⁸F]FDG PET/CT. Metabolic parameters were shown to be useful to differentiate between benign and malignant nasopharyngeal lesions, and NPR showed the best diagnostic performance.

Aim: To evaluate the role of fluorine-18 fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) radiomics features (RFs) for predicting clinicopathological factors (CPFs) and prognosis in patients with resected lung squamous cell cancer (LSCC).

Material and methods: Patients with early-stage (stage I-III) LSCC who underwent ¹⁸F-FDG PET/CT before surgical resection between August 2012 and February 2020 were analyzed. Patients who received neoadjuvant chemotherapy or radiotherapy were excluded from the study. The maximum standard uptake value (SUVmax) and RFs were extracted from PET images for primary tumors. The diagnostic performances of PET parameters in groups of tumor differentiation, stage, and mediastinal lymph node metastasis (MLNM) status were evaluated. The study endpoints were overall survival (OS) and progression-free survival (PFS). Univariate and multivariate analyses were performed with RFs, SUVmax, and CPFs to find independent predictors of PFS and OS.

Results: A total of 77 patients (5 female, 72 male) were included in the study. SUVmax and GLCM entropy were independently associated with tumor differentiation. The only parameter with significant diagnostic performance for MLNM was GLZLM-SLZGE. Tumor diameter and NGLDM busyness were independently associated with the stage. MLNM and tumor differentiation were found to be independent predictors of PFS. NGLDM contrast and MLNM were independently associated with OS.

Conclusion: Using radiomic features in addition to CPFs to predict disease recurrence and shorter overall survival can guide precision medicine in patients with LSCC.

Although rare, a metastatic renal cell carcinoma could present with ⁶⁸Ga-DOTATATE avidity. A 66-year-old man with von Hippel-Lindau syndrome (VHL) presented with ⁶⁸Ga-DOTATATE uptake in the pancreatic head, splenic hilar region, and multiple osseous sites, including the right lateral portion of the T9 vertebrae. Biopsy of the T9 lesion confirmed metastatic renal cell carcinoma. Various VHL-associated cancers may display ⁶⁸Ga-DOTATATE avidity, which can change and guide clinical decisions for the patient.

We describe the case of 74-year-old-male, previously treated with fronto-parietal craniotomy due to primary glioblastoma multiforme (GBM), followed by concurrent radiation therapy (RT) and temozolomide (TMZ) chemotherapy. Magnetic resonance imaging (MRI) of the brain, at 1 month after completing RT + TMZ, depicted partial response. Three months later, the patient was submitted to a further brain MRI, that resulted doubtful for therapy induced changes (i.e., pseudoprogression). The patient, who had been previously treated with prostatectomy for prostate cancer (PC), underwent a positron emission tomography/computed tomography (PET/CT) scan with ¹⁸F-choline for PC biochemical recurrence. ¹⁸F-choline whole body PET/CT resulted negative for PC relapse, while segmental brain PET, co-registered with MRI, demonstrated increased tracer uptake corresponding to tumor boundaries. In order to solve differential diagnosis between pseudoprogression and GBM recurrence, brain PET/CT with ¹⁸F-L-dihydroxy-phenil-alanine (¹⁸F-DOPA) was subsequently performed: fused axial PET/MRI images showed increased ¹⁸F-DOPA incorporation in the peri-tumoral edema, but not in tumor boundaries, consistent with the suspicion of GBM pseudoprogression, as then confirmed by clinical and radiological follow-up.