Pub Date : 2020-07-16DOI: 10.15406/OGIJ.2020.11.00511
V. Manuel, Luján Irastorza Jesús Estuardo, Ávila Pérez Felipe de Jesús, Á. Daniela, P. Maruxa, D. Carlos
Objective: To report the incidence of thrombophilias and importance in the development of thrombotic events in a population of Mexican women. Methods: Is a retrospective, observational and cross-sectional study of 184 women of reproductive age, where the age, weight, height and study of hereditary thrombophilias of FVL-G1691A, PT-G20210A, MTHFR-C677T and PAI-1 4G/5G were studied. Four groups were formed: 1) FVL-G1691A, 2) PT-G20210A, 3) MTHFR-C677T and 4) PAI-1 4G/5G, each group was separated by homozygous and heterozygous mutation. Results: MTHFR-C677T and PAI-1 4G/5G present higher incidence (48.9 and 64%), when comparing with FVL-G1691A and PT-G20210A (3.8 and 0.5%) (p<0.05), higher incidence of PAI-1 4G/5G was observed, when compared to MTHFR-C677T (64.6 vs. 48.9%, p<0.05), difference that was not observed when comparing FVL-G1691A with PT-G20210A (3.8 vs. 0.5%, p>0.05). When patients presented only one thrombophilia, the highest incidence is of MTHFR-C677T and PAI-1 4G>5G (16.5 and 35.2%). Patients with multiple thrombophilias had an incidence of MTHFR-C677T with PAI-1 4G/5G of 30.2%. Conclusion: Our results in the population of Mexican women, we report a high incidence of the MTHFR-C677T and PAI-1 4G / 5G mutation, which makes them susceptible to the development of thrombotic events.
{"title":"Incidence of hereditary thrombofilies in a population of Mexican women","authors":"V. Manuel, Luján Irastorza Jesús Estuardo, Ávila Pérez Felipe de Jesús, Á. Daniela, P. Maruxa, D. Carlos","doi":"10.15406/OGIJ.2020.11.00511","DOIUrl":"https://doi.org/10.15406/OGIJ.2020.11.00511","url":null,"abstract":"Objective: To report the incidence of thrombophilias and importance in the development of thrombotic events in a population of Mexican women. Methods: Is a retrospective, observational and cross-sectional study of 184 women of reproductive age, where the age, weight, height and study of hereditary thrombophilias of FVL-G1691A, PT-G20210A, MTHFR-C677T and PAI-1 4G/5G were studied. Four groups were formed: 1) FVL-G1691A, 2) PT-G20210A, 3) MTHFR-C677T and 4) PAI-1 4G/5G, each group was separated by homozygous and heterozygous mutation. Results: MTHFR-C677T and PAI-1 4G/5G present higher incidence (48.9 and 64%), when comparing with FVL-G1691A and PT-G20210A (3.8 and 0.5%) (p<0.05), higher incidence of PAI-1 4G/5G was observed, when compared to MTHFR-C677T (64.6 vs. 48.9%, p<0.05), difference that was not observed when comparing FVL-G1691A with PT-G20210A (3.8 vs. 0.5%, p>0.05). When patients presented only one thrombophilia, the highest incidence is of MTHFR-C677T and PAI-1 4G>5G (16.5 and 35.2%). Patients with multiple thrombophilias had an incidence of MTHFR-C677T with PAI-1 4G/5G of 30.2%. Conclusion: Our results in the population of Mexican women, we report a high incidence of the MTHFR-C677T and PAI-1 4G / 5G mutation, which makes them susceptible to the development of thrombotic events.","PeriodicalId":19389,"journal":{"name":"Obstetrics & Gynecology International Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75311146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-03DOI: 10.15406/ogij.2020.11.00510
A. Yehia, Hala Alansary
Objective: To compare the therapeutic efficacy of prostaglandins when they used alone versus a combination therapy of prostaglandins and a nitric oxide (NO) donor as isosorbide-5-mononitrate to induce cervical ripening and effacement for induction of the second trimester missed abortion and occurrence of complete abortion. Methods: A Randomized clinical trial study in which 160 Second trimester (13-26weeks) missed abortion pregnant women admitted for medical induction of abortion, were randomly divided into two group (80 patients in each). One group received only vaginal Misoprostol and the other group received combined vaginal Misoprostol with Isosorbide-5-mononitrate. To determine the efficacy in form of " induction abortion interval ": the duration interval between the beginning of the induction and the complete expulsion of the abortus and also the number of the doses of misoprostol needed to complete expulsion and also the adverse events that increased or newly discovered when prostaglandins and a nitric oxide donor used together such as severe bleeding, headache, abdominal pain, pelvic pain, sever hypotension, backache, fever, nausea and vomiting. Results: It is proved in the study that combination between misoprostol and isosorbide mononitrate gives better results regarding cervical consistency improvement, cervical dilatation, effacement, the whole induction time and the number of misoprostol doses needed to complete expulsion when compared to misoprostol alone and also fewer side effects as abdominal pain. Conclusion: Misoprostol is a good cervical ripening agent when used alone but we can get a benefit from combining both misoprostol and NO donor (isosorbide-5- mononitrate) making a synergistic action with fewer side effects.
{"title":"Role of adding Isosorbide-5-Mononitrate to misoprostol in Induction of the second trimesteric abortion, a randomized controlled trial","authors":"A. Yehia, Hala Alansary","doi":"10.15406/ogij.2020.11.00510","DOIUrl":"https://doi.org/10.15406/ogij.2020.11.00510","url":null,"abstract":"Objective: To compare the therapeutic efficacy of prostaglandins when they used alone versus a combination therapy of prostaglandins and a nitric oxide (NO) donor as isosorbide-5-mononitrate to induce cervical ripening and effacement for induction of the second trimester missed abortion and occurrence of complete abortion. Methods: A Randomized clinical trial study in which 160 Second trimester (13-26weeks) missed abortion pregnant women admitted for medical induction of abortion, were randomly divided into two group (80 patients in each). One group received only vaginal Misoprostol and the other group received combined vaginal Misoprostol with Isosorbide-5-mononitrate. To determine the efficacy in form of \" induction abortion interval \": the duration interval between the beginning of the induction and the complete expulsion of the abortus and also the number of the doses of misoprostol needed to complete expulsion and also the adverse events that increased or newly discovered when prostaglandins and a nitric oxide donor used together such as severe bleeding, headache, abdominal pain, pelvic pain, sever hypotension, backache, fever, nausea and vomiting. Results: It is proved in the study that combination between misoprostol and isosorbide mononitrate gives better results regarding cervical consistency improvement, cervical dilatation, effacement, the whole induction time and the number of misoprostol doses needed to complete expulsion when compared to misoprostol alone and also fewer side effects as abdominal pain. Conclusion: Misoprostol is a good cervical ripening agent when used alone but we can get a benefit from combining both misoprostol and NO donor (isosorbide-5- mononitrate) making a synergistic action with fewer side effects.","PeriodicalId":19389,"journal":{"name":"Obstetrics & Gynecology International Journal","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90861189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-19DOI: 10.15406/ogij.2020.11.00509
Rosmaria ., Sri Yun Utama, Titik Hindriati, Diniyati .
Background: The consumption of Fe tablets needs to be the attention of midwives as one of the spearheads in providing antenatal care services. Due to the low level of compliance of pregnant women to consume Fe tablets, it is necessary to provide appropriate counseling as an effort to increase compliance with Fe tablets. Objective: This study aimed to determine the effectiveness of the application model (Sumiferos) for preventing anemia with pregnant women compliance in consuming Fe tablets at Putri Ayu Health Center in Jambi city. Materials and methods: This study used a quasi-experimental research design with a post-test design by involving an intervention group and a control group (post-test), two group designs. With the total of 70 subjects;the intervention group, 35 respondents were given a website application (sumiferos), and a control group 35 respondents were given a leflet. After a month, the number of Fe tablets that have been consumed was monitored. Compliance of pregnant women in consuming Fe tablets required a monitoring or supervisioncarried out by health workers. Therefore, an intervention was given by using a website-based application (sumiferos) for pregnant women as a communication tool that has been created and designed previously by researchers. Results: Posttest statistical analysis showed that pregnant women who were given a website application (sumiferos) in the intervention group showed better compliance than pregnant women in the control group given lefket. Conclusion: Based on the results,a website application (sumiferos) is more effective than leaflets in improving maternal compliance to consume Fe tablets given by health workers.
{"title":"Effectiveness of website application (Sumiferos) for preventing anemia with pregnant women compliance in consuming Fe tablets","authors":"Rosmaria ., Sri Yun Utama, Titik Hindriati, Diniyati .","doi":"10.15406/ogij.2020.11.00509","DOIUrl":"https://doi.org/10.15406/ogij.2020.11.00509","url":null,"abstract":"Background: The consumption of Fe tablets needs to be the attention of midwives as one of the spearheads in providing antenatal care services. Due to the low level of compliance of pregnant women to consume Fe tablets, it is necessary to provide appropriate counseling as an effort to increase compliance with Fe tablets. Objective: This study aimed to determine the effectiveness of the application model (Sumiferos) for preventing anemia with pregnant women compliance in consuming Fe tablets at Putri Ayu Health Center in Jambi city. Materials and methods: This study used a quasi-experimental research design with a post-test design by involving an intervention group and a control group (post-test), two group designs. With the total of 70 subjects;the intervention group, 35 respondents were given a website application (sumiferos), and a control group 35 respondents were given a leflet. After a month, the number of Fe tablets that have been consumed was monitored. Compliance of pregnant women in consuming Fe tablets required a monitoring or supervisioncarried out by health workers. Therefore, an intervention was given by using a website-based application (sumiferos) for pregnant women as a communication tool that has been created and designed previously by researchers. Results: Posttest statistical analysis showed that pregnant women who were given a website application (sumiferos) in the intervention group showed better compliance than pregnant women in the control group given lefket. Conclusion: Based on the results,a website application (sumiferos) is more effective than leaflets in improving maternal compliance to consume Fe tablets given by health workers.","PeriodicalId":19389,"journal":{"name":"Obstetrics & Gynecology International Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87705359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-15DOI: 10.15406/ogij.2020.11.00508
T. Baba, Yasuko Fukagawa, H. Itamochi, Chie Sato, Hidetoshi Tomabechi, T. Nagasawa, M. Kagabu, T. Shoji, T. Sugai
Serous psammocarcinoma is a rare subtype of serous carcinoma in which a significant number of psammoma bodies are present histologically. Because it is an extremely rare disease, the pathogenesis of the disease remains unclear. Here we present a case of primary ovarian serous psammocarcinoma in which computed tomography (CT) imaging of the abdomen was useful for the diagnosis. A female patient was referred to our department with a complaint of abdominal distention. Pelvic magnetic resonance imaging revealed a multifocal tumor with a papillary enhancement in the right appendicular region, and abdominal CT imaging exhibited marked calcification of the enhancement. She underwent a laparotomy for suspected right ovarian cancer. As postoperative pathological examination revealed dominant stromal infiltration of psammoma bodies beneath peritoneum, this case was diagnosed as primary ovarian serous psammocarcinoma at FIGO Stage IIB. The patient was treated with six courses of paclitaxel plus carboplat in after the surgery. She is currently under outpatient observation without any signs of recurrence after 8 years of treatment. The case of significant calcification of the intra cystic enrichment on CT imaging is considered to be a case of this disease.
{"title":"Primary ovarian serous psammocarcinoma-a case report with mini literature review","authors":"T. Baba, Yasuko Fukagawa, H. Itamochi, Chie Sato, Hidetoshi Tomabechi, T. Nagasawa, M. Kagabu, T. Shoji, T. Sugai","doi":"10.15406/ogij.2020.11.00508","DOIUrl":"https://doi.org/10.15406/ogij.2020.11.00508","url":null,"abstract":"Serous psammocarcinoma is a rare subtype of serous carcinoma in which a significant number of psammoma bodies are present histologically. Because it is an extremely rare disease, the pathogenesis of the disease remains unclear. Here we present a case of primary ovarian serous psammocarcinoma in which computed tomography (CT) imaging of the abdomen was useful for the diagnosis. A female patient was referred to our department with a complaint of abdominal distention. Pelvic magnetic resonance imaging revealed a multifocal tumor with a papillary enhancement in the right appendicular region, and abdominal CT imaging exhibited marked calcification of the enhancement. She underwent a laparotomy for suspected right ovarian cancer. As postoperative pathological examination revealed dominant stromal infiltration of psammoma bodies beneath peritoneum, this case was diagnosed as primary ovarian serous psammocarcinoma at FIGO Stage IIB. The patient was treated with six courses of paclitaxel plus carboplat in after the surgery. She is currently under outpatient observation without any signs of recurrence after 8 years of treatment. The case of significant calcification of the intra cystic enrichment on CT imaging is considered to be a case of this disease.","PeriodicalId":19389,"journal":{"name":"Obstetrics & Gynecology International Journal","volume":"197 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75925161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-12DOI: 10.22541/au.159200518.87946772
K. Jong, C. Stewart, Gretel Cr van Hoecke, H. Ponssen
Maternal acidosis, due to acute starvation, is a medical emergency in which both mother and child are at risk for significant morbidity and mortality. Acute starvation in the third trimester of pregnancy causing maternal ketoacidosis should be identified rapidly, followed by the right treatment immediately. If starvation has occurred, substituting nutrients, intravenous glucose and prevention of circulatory hypovolemia are recommended. This case report presents a pregnant woman with acute starvation ketoacidosis. In this case, we present warning symptoms, such as respiratory distress, and the severe consequences of maternal acidosis.
{"title":"Severe metabolic acidosis and respiratory distress due to acute starvation in pregnancy: a case report","authors":"K. Jong, C. Stewart, Gretel Cr van Hoecke, H. Ponssen","doi":"10.22541/au.159200518.87946772","DOIUrl":"https://doi.org/10.22541/au.159200518.87946772","url":null,"abstract":"Maternal acidosis, due to acute starvation, is a medical emergency in which both mother and child are at risk for significant morbidity and mortality. Acute starvation in the third trimester of pregnancy causing maternal ketoacidosis should be identified rapidly, followed by the right treatment immediately. If starvation has occurred, substituting nutrients, intravenous glucose and prevention of circulatory hypovolemia are recommended. This case report presents a pregnant woman with acute starvation ketoacidosis. In this case, we present warning symptoms, such as respiratory distress, and the severe consequences of maternal acidosis.","PeriodicalId":19389,"journal":{"name":"Obstetrics & Gynecology International Journal","volume":"131 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85296263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-05DOI: 10.15406/ogij.2020.11.00506
M. Javed
Cancer has significantly harmful effects on sperm count, motility and sexual life of the survivor, thereby adversely affecting the fertility and post cancer quality of life. Use of safer chemotherapeutic agents, protection from radiation damage, cryopreservation of sperm and testicular tissue and use of protective drugs to reduce testicular damage is recommended. More research is needed to safeguard fertility of cancer affected children as testicular tissue cryopreservation is the only fertility preservation option. Advanced understanding of in vitro sperm production is needed. In this era of advanced assisted reproduction, the minimum requirement for fertilization is one healthy sperm for one oocyte. Children born after chemotherapy do not have statistically significant increase in malignant neoplasms. Proper cancer counseling and referral for fertility preservation are of high importance to protect fertility. The focus of this review is to share knowledge of sperm formation, importance of sperm count, nature of damage to male fertility, remedies to overcome damage and to improve post cancer quality of life of male cancer survivors.
{"title":"Sperm count and future challenges for cancer patients","authors":"M. Javed","doi":"10.15406/ogij.2020.11.00506","DOIUrl":"https://doi.org/10.15406/ogij.2020.11.00506","url":null,"abstract":"Cancer has significantly harmful effects on sperm count, motility and sexual life of the survivor, thereby adversely affecting the fertility and post cancer quality of life. Use of safer chemotherapeutic agents, protection from radiation damage, cryopreservation of sperm and testicular tissue and use of protective drugs to reduce testicular damage is recommended. More research is needed to safeguard fertility of cancer affected children as testicular tissue cryopreservation is the only fertility preservation option. Advanced understanding of in vitro sperm production is needed. In this era of advanced assisted reproduction, the minimum requirement for fertilization is one healthy sperm for one oocyte. Children born after chemotherapy do not have statistically significant increase in malignant neoplasms. Proper cancer counseling and referral for fertility preservation are of high importance to protect fertility. The focus of this review is to share knowledge of sperm formation, importance of sperm count, nature of damage to male fertility, remedies to overcome damage and to improve post cancer quality of life of male cancer survivors.","PeriodicalId":19389,"journal":{"name":"Obstetrics & Gynecology International Journal","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73745220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-25DOI: 10.15406/ogij.2020.11.00505
E. Henri, E. Cécile, Egbe Obichemti Thomas, H. Gregory, Nida Martine Colette, B. Merlin, Tocki Toutou Grâce, Foumane Pascal, A. Dieudonné, Mboudou Emile Télesphore
Introduction: The vaginal flora consists of bacilli of Doderleïn (various species of lactobacilli) which constitute a biofilm on the mucosa. These bacteria play a protective role by inhibiting the growth, adhesion or expansion of other microorganisms. To do this, various mechanisms are deployed, including the secretion of organic acids, antimicrobial substances, competition for nutrients and receptor sites as well as steric exclusion. This balance is sometimes called into question by the use of oral medications and antiseptics for vaginal cleansing, oral contraception, diseases such as the Human Immunodeficiency Virus (HIV) or diabetes. Objective: The objective of this work was to study the vaginal flora of women residing in the city of Douala. Methodology: we carried out in three health structures in the city of Douala a transverse analytical study for seven (7) months in women aged at least 21 years. We randomly included 540 women who gave their written and signed consent. The variables of interest were socio-demographic, clinical and microbiological variables. Gram staining was used and read using an optical microscope for the identification of microorganisms and the classification of flora consisting of bacteria from vaginal secretions. The statistical tests used for the comparison of the numbers were chi-square and the exact fisher test with a significance threshold of 5% (p<0.05) Results: A total of five hundred and forty (540) women had their samples collected. The majority age group was that of 30-40 years with 28.30% of cases. The mean age was 42.58 years (+/- 13.37). Four types of vaginal flora have been identified, in particular Type 4 (complete disappearance of the Döderlein flora with the appearance of abundant, polymorphic replacement flora and presence of clues-cells) with 36.30% of cases; Type 3 (rare, minority lacto-bacillary flora with the appearance of a substitution flora with a dominant morphology) at 32.20%; Type 1 (mainly Döderlein flora: lactobacilli) at 17.20%; Type 2 (Döderlein flora present and predominant but with a substitution flora without dominant morphology) at 14.30%. The factors associated with the flora imbalance were scented soaps (OR=1.84; 95% CI=1.77-2.73; P=0.001), antiseptic products (OR=2.04; 95% CI=1, 05-5.67; P=0.004) and the risk increased by combining them (OR=4.04; 95% CI=3.92-6.49; P=0.001) 95% CI=1.77-2.73; P=0.001), Oral contraception, HIV infection and diabetes also altered the flora. In addition, the presence of yeasts and mycelial filaments also favoured the degradation of the flora. On the other hand, drinking water appeared as a protective factor (OR=0.19; 95% CI=0.043-0.84; P=0.028). Conclusion: the vaginal flora of women residing in Douala is mainly degraded in a cumulative percentage of 68.50% and represented by types 4 and 3.
{"title":"Vaginal ecology in Cameroonian urban areas: study of the flora of douala city inhabitants","authors":"E. Henri, E. Cécile, Egbe Obichemti Thomas, H. Gregory, Nida Martine Colette, B. Merlin, Tocki Toutou Grâce, Foumane Pascal, A. Dieudonné, Mboudou Emile Télesphore","doi":"10.15406/ogij.2020.11.00505","DOIUrl":"https://doi.org/10.15406/ogij.2020.11.00505","url":null,"abstract":"Introduction: The vaginal flora consists of bacilli of Doderleïn (various species of lactobacilli) which constitute a biofilm on the mucosa. These bacteria play a protective role by inhibiting the growth, adhesion or expansion of other microorganisms. To do this, various mechanisms are deployed, including the secretion of organic acids, antimicrobial substances, competition for nutrients and receptor sites as well as steric exclusion. This balance is sometimes called into question by the use of oral medications and antiseptics for vaginal cleansing, oral contraception, diseases such as the Human Immunodeficiency Virus (HIV) or diabetes. Objective: The objective of this work was to study the vaginal flora of women residing in the city of Douala. Methodology: we carried out in three health structures in the city of Douala a transverse analytical study for seven (7) months in women aged at least 21 years. We randomly included 540 women who gave their written and signed consent. The variables of interest were socio-demographic, clinical and microbiological variables. Gram staining was used and read using an optical microscope for the identification of microorganisms and the classification of flora consisting of bacteria from vaginal secretions. The statistical tests used for the comparison of the numbers were chi-square and the exact fisher test with a significance threshold of 5% (p<0.05) Results: A total of five hundred and forty (540) women had their samples collected. The majority age group was that of 30-40 years with 28.30% of cases. The mean age was 42.58 years (+/- 13.37). Four types of vaginal flora have been identified, in particular Type 4 (complete disappearance of the Döderlein flora with the appearance of abundant, polymorphic replacement flora and presence of clues-cells) with 36.30% of cases; Type 3 (rare, minority lacto-bacillary flora with the appearance of a substitution flora with a dominant morphology) at 32.20%; Type 1 (mainly Döderlein flora: lactobacilli) at 17.20%; Type 2 (Döderlein flora present and predominant but with a substitution flora without dominant morphology) at 14.30%. The factors associated with the flora imbalance were scented soaps (OR=1.84; 95% CI=1.77-2.73; P=0.001), antiseptic products (OR=2.04; 95% CI=1, 05-5.67; P=0.004) and the risk increased by combining them (OR=4.04; 95% CI=3.92-6.49; P=0.001) 95% CI=1.77-2.73; P=0.001), Oral contraception, HIV infection and diabetes also altered the flora. In addition, the presence of yeasts and mycelial filaments also favoured the degradation of the flora. On the other hand, drinking water appeared as a protective factor (OR=0.19; 95% CI=0.043-0.84; P=0.028). Conclusion: the vaginal flora of women residing in Douala is mainly degraded in a cumulative percentage of 68.50% and represented by types 4 and 3.","PeriodicalId":19389,"journal":{"name":"Obstetrics & Gynecology International Journal","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76372013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-22DOI: 10.15406/OGIJ.2020.11.00504
K. DzhabbarovaYu, T. IsmoilovaSh, Musakhodzhayeva Da
The frequency of development of hypertensive states in IDA reaches 32-45%. The pathogenesis of the combined complications of pregnancy with anemia and preeclampsia, including immunological aspects has been little studied. Purpose: to clarify the role of violations general and local cytokine status in pregnant women with anemia in the genesis of preeclampsia and justify the need to include immuno suppressants for the prevention and treatment of preeclampsia. Materials and methods: In 96 pregnant women with iron deficiency anemia (IDA) and preeclampsia in the third trimester of gestation the cytokine status of IL-1β, IL-6, IL-8, TNFα and lactoferrin in the serum of peripheral blood and in extracts of the placenta decidual tissue was examined by ELISA. Pregnant women were divided into 4 groups: 24-with mild anemia, 18-with moderate anemia, 26-with preeclampsia and with mild anemia and 28 pregnant women with preeclampsia and with moderate anemia. Results: It has been established that preeclampsia on the background of IDA is accompanied by a significant increase in the level of pro-inflammatory cytokines (p<0,05) and the acute phase protein lactoferrin (p<0,05) on the systemic and to a greater extent on the local level in the development of preeclampsia on the background of anemia of moderate severity (p<0,05). Discussion: The data obtained confirm the involvement of the immune system in the pathogenesis of preeclampsia, one of the trigger mechanisms of which is the immune imbalance in iron deficiency anemia. A pathogenetic rationale for the use of immunosuppressive therapy for combined pathology is given. Conclusion: The use of placental hormone - progesterone as an immunosuppressive drug in terms of substantiating new immunotherapy strategies for the prevention of preeclampsia is a topical trend in obstetric practice.
{"title":"Role of cytokines in pregnant women with chronic iron deficiency anemia in preeclampsia pathogenesis","authors":"K. DzhabbarovaYu, T. IsmoilovaSh, Musakhodzhayeva Da","doi":"10.15406/OGIJ.2020.11.00504","DOIUrl":"https://doi.org/10.15406/OGIJ.2020.11.00504","url":null,"abstract":"The frequency of development of hypertensive states in IDA reaches 32-45%. The pathogenesis of the combined complications of pregnancy with anemia and preeclampsia, including immunological aspects has been little studied. Purpose: to clarify the role of violations general and local cytokine status in pregnant women with anemia in the genesis of preeclampsia and justify the need to include immuno suppressants for the prevention and treatment of preeclampsia. Materials and methods: In 96 pregnant women with iron deficiency anemia (IDA) and preeclampsia in the third trimester of gestation the cytokine status of IL-1β, IL-6, IL-8, TNFα and lactoferrin in the serum of peripheral blood and in extracts of the placenta decidual tissue was examined by ELISA. Pregnant women were divided into 4 groups: 24-with mild anemia, 18-with moderate anemia, 26-with preeclampsia and with mild anemia and 28 pregnant women with preeclampsia and with moderate anemia. Results: It has been established that preeclampsia on the background of IDA is accompanied by a significant increase in the level of pro-inflammatory cytokines (p<0,05) and the acute phase protein lactoferrin (p<0,05) on the systemic and to a greater extent on the local level in the development of preeclampsia on the background of anemia of moderate severity (p<0,05). Discussion: The data obtained confirm the involvement of the immune system in the pathogenesis of preeclampsia, one of the trigger mechanisms of which is the immune imbalance in iron deficiency anemia. A pathogenetic rationale for the use of immunosuppressive therapy for combined pathology is given. Conclusion: The use of placental hormone - progesterone as an immunosuppressive drug in terms of substantiating new immunotherapy strategies for the prevention of preeclampsia is a topical trend in obstetric practice.","PeriodicalId":19389,"journal":{"name":"Obstetrics & Gynecology International Journal","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84132876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-19DOI: 10.15406/ogij.2020.11.00503
Elsayed M. Elshamy, Ayman Soliman
Objective: To compare between luteal phase clomiphene citrate and second cycle day clomiphene citrate on the thickness of the endometrium and clinical pregnancy rates in women with polycystic ovary syndrome. Methods: a prospective observational study conducted on 196 women with Polycystic ovary syndrome divided into two groups: Group 1 (98 patients) received 100mg of clomiphene citrate daily for 5 days starting on second cycle day and Group 2 (98 patients) received 100mg of clomiphene citrate daily starting in the luteal phase before onset of withdrawal bleeding for 5 days. Treatment and follow up applied for three cycles. Outcome measures were collected and analyzed and women who got pregnant were followed until 12 weeks of pregnancy. Results: no significant differences between the two groups regarding pre-ovulatory endometrial thickness (8.3mm in group 1vs 8.8mm in group 2), number of mature follicles (1.62 in group 1vs 1.57 in group 2) and mid-luteal serum progesterone levels(14.63ng/ml in group 1vs 14.9ng/ml in group 2). 34 women (35%) got pregnant in group 1 and 37 women (38%) in-group 2 and three patients had miscarriage in each group without any statistical significance. Conclusion: the present study does not support luteal clomiphene citrate over second cycle day clomiphene citrate to induce ovulation in infertile women with polycystic ovary syndrome.
目的:比较黄体期克罗米芬与第二周期天克罗米芬对多囊卵巢综合征患者子宫内膜厚度及临床妊娠率的影响。方法:对196例多囊卵巢综合征女性患者进行前瞻性观察研究，分为两组:1组(98例)从第二周期日开始每日100mg枸橼酸克罗米芬，连续5天;2组(98例)从停药性出血前黄体期开始每日100mg枸橼酸克罗米芬，连续5天。治疗随访3个周期。研究人员收集并分析了结果指标，并对怀孕的妇女进行了随访，直到怀孕12周。结果:两组患者排卵前子宫内膜厚度(1组8.3mm vs 2组8.9 mm)、成熟卵泡数(1组1.62 vs 2组1.57)、黄体中期血清黄体酮水平(1组14.63ng/ml vs 2组14.9ng/ml)差异均无统计学意义。1组34例(35%)妊娠，2组37例(38%)流产，两组各3例流产，差异均无统计学意义。结论:本研究不支持枸橼酸克罗米芬在第二周期内诱导多囊卵巢综合征不孕妇女排卵。
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Pub Date : 2020-05-15DOI: 10.15406/ogij.2020.11.00502
Duro Gómez Jorge, Vendrell Aranda Celia María
and its negative predictive value is 97.52%. 11 For this reason, hysteroscopy is especially useful in diagnosis recognizing specific signs of chronic endometritis. 1,11,12 In these patients, two samples should be taken, one for a microbiological study and the other for a histopathological study. Cicinelli et al have obtained in their studies a diagnostic correlation of up to 93.4% based on hysteroscopic criteria during the follicular phase that suggest chronic endometritis.
{"title":"Chronic endometritis: an hidden pathology","authors":"Duro Gómez Jorge, Vendrell Aranda Celia María","doi":"10.15406/ogij.2020.11.00502","DOIUrl":"https://doi.org/10.15406/ogij.2020.11.00502","url":null,"abstract":"and its negative predictive value is 97.52%. 11 For this reason, hysteroscopy is especially useful in diagnosis recognizing specific signs of chronic endometritis. 1,11,12 In these patients, two samples should be taken, one for a microbiological study and the other for a histopathological study. Cicinelli et al have obtained in their studies a diagnostic correlation of up to 93.4% based on hysteroscopic criteria during the follicular phase that suggest chronic endometritis.","PeriodicalId":19389,"journal":{"name":"Obstetrics & Gynecology International Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79581249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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