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Cerebroplacental ratio in gestational hypertension and its impact on neonatal weight 妊娠期高血压的脑胎盘比及其对新生儿体重的影响
Pub Date : 2020-09-30 DOI: 10.15406/ogij.2020.11.00530
M. Alalfy, A. Okasha, Omar Abdalfatah
Background: Pregnancy a physiological process that involves changes in vascular system responsiveness that affects the placental development in direct and indirect methods by hormonal and other signals that are critical in normal blood flow rates within the fetal system. Predicting fetal outcome using sonographic indices is considered a noninvasive valuable protocol to manage cases with hypertensive disorders with pregnancy. Fetal weight is one of the critical issues faced by obstetricians and perinatologists Aim of the study: to determine the value of cerebro placental ratio in predictability of neonatal weight in cases of gestational hypertension. Patients and Methods: A prospective observational cross sectional study that included 100 pregnant women, 50 ladies had gestational hypertension and 50 women as normal control group attending the antenatal care clinic of Algezeera hospital. Ultrasonographic assessment was carried out with evaluation of routine fetal biometry in addition to Middle cerebral artery (MCA), Umbilical artery (UA) Doppler indices. Results: UA PI, MCA PI, CPR, Fetal weight and birth weight were statistically significantly higher among the control research group in comparison to the hypertension with pregnancy research group (p values<0.001). Conclusion: Cerebroplacental ratio is a promising ultrasonographic marker for fetal and neonatal weight that could aid in prediction of neonatal wellbeing and clinical prognosis of hypertensive cases in pregnancy.
背景:妊娠是一个生理过程,涉及血管系统反应性的变化,通过激素和其他信号直接或间接地影响胎盘发育,这些信号对胎儿系统内的正常血流速率至关重要。利用超声指标预测胎儿结局被认为是一种无创的有价值的方案来管理妊娠期高血压疾病的病例。胎儿体重是产科医生和围产期医生面临的关键问题之一,本研究的目的是:确定在妊娠期高血压病例中,脑胎盘比在新生儿体重预测中的价值。患者与方法:采用前瞻性横断面观察研究,纳入在Algezeera医院产前保健门诊就诊的100名孕妇,其中50名为妊娠期高血压患者,50名为正常对照组。超声检查结合常规胎儿生物测量、大脑中动脉(MCA)、脐动脉(UA)多普勒指数进行评估。结果:对照组UA PI、MCA PI、CPR、胎儿体重、出生体重均高于妊高征研究组,差异有统计学意义(p值<0.001)。结论:脑胎盘比是一种很有前途的胎儿和新生儿体重超声指标,有助于预测新生儿健康状况和妊娠期高血压患者的临床预后。
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引用次数: 1
Educational intervention for the prevention of sexually transmitted infections in basic secondary teachers 对初级中学教师进行预防性传播感染的教育干预
Pub Date : 2020-09-22 DOI: 10.15406/ogij.2020.11.00529
A. Alfaro, Damarys Chacón O`farrill
Introduction: Among the factors that increase sexual infections in adolescence are the early initiation of sexual relations, adolescence is considered a stage of vulnerability and exposure to risky social and/or sexual behaviors that expose them to sexual and reproductive health problems such as unwanted pregnancies and sexually transmitted infections, so it is essential that they are taught in schools comprehensive sexuality education Objective: To assess the effects of educational intervention for the prevention of sexually transmitted infections in teachers of the Antonio José Oviedo Basic Secondary School. San José de las Lajas, Mayabeque during the period: October 2017 to February 2019. Method: A quasi-experimental educational intervention study with a mixed approach to the 40 teachers included in the permanent staff of the center, a survey was applied prior to the intervention that allowed characterizing the teachers according to sociodemographic variables, exploring the level of knowledge, attitudes, perception of risk and beliefs about STIs. 15 work sessions were held and tools were given to facilitate the work on these issues with adolescents. A post-intervention survey was applied to evaluate its effectiveness. Descriptive and inferential statistics (J squared) were applied. Results: female sex predominated (72.5%), with ages between 30 and 40 years (42.5%), in males the perception of lower risk prevailed compared to females. Knowledge, beliefs, attitudes and perception of risk about STIs were inadequate prior to intervention, after intervention they increased significantly in: 92.5%, 65%, 77.5% and 70% respectively. Conclusions: The educational intervention was effective in contributing to the improvement of comprehensive sexuality education in the school environment.
导言:增加青少年性感染的因素之一是过早开始性关系,青少年被认为是易受伤害的阶段,易受到危险的社会和/或性行为的影响,使他们面临诸如意外怀孕和性传播感染等性健康和生殖健康问题,因此在学校对他们进行全面的性教育至关重要。目的:评价教育干预对安东尼奥·乔斯·奥维耶多基础中学教师性传播感染预防的效果。期间:2017年10月至2019年2月。方法:采用混合方法对该中心40名教师进行准实验教育干预研究,在干预前采用调查方法,根据社会人口统计学变量对教师进行特征化,探讨教师对性传播感染的知识水平、态度、风险感知和信念。举行了15次工作会议,并提供了工具,以促进与青少年就这些问题开展工作。采用干预后调查来评估其有效性。采用描述性统计和推理统计(J平方)。结果:女性占多数(72.5%),年龄在30 - 40岁之间(42.5%),男性比女性认为风险更低。干预前性传播感染知识、信念、态度和风险感知不足,干预后性传播感染知识、信念、态度和风险感知分别显著增加92.5%、65%、77.5%和70%。结论:教育干预对改善学校环境的全面性教育是有效的。
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引用次数: 0
A case of labioscrotal ovotestis in Madagascar with review of the literature 马达加斯加阴唇阴囊卵睾1例并复习文献
Pub Date : 2020-09-11 DOI: 10.15406/OGIJ.2020.11.00528
Ranaivoson Haingo Voahangy Rabetafika, Z. I. Raivoherivony, A. Raherison, M. Andriamanarivo, N. Randrianjafisamindrakotroka
Among the disorder sexual development which regroups several pathological entities, true hermaphroditism or Ovotestis disorder remains a rare variety. We report a case of true hermaphroditism, diagnosed at the age of 15 years. Despite the presence of sexual ambiguity at birth, the female gender has been declared. The presence of a female genital tract and secondary sexual characteristics has led the choice of scrotal excision. The surgical procedure, the histological study bestow the positive diagnosis and allowed to revise the sexual ambiguity.
在将多种病理实体重新组合的性发育障碍中,真正的雌雄同体或卵睾丸障碍仍然是一个罕见的品种。我们报告一个真正的雌雄同体的情况下,诊断在15岁。尽管在出生时存在性别歧义,但女性性别已被宣布。存在女性生殖道和第二性征导致选择阴囊切除。手术过程,组织学研究给予积极的诊断,并允许修改性别歧义。
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引用次数: 0
Relationship between serum survivin levels before radiotherapy and clinical response in patient with stage iib cervical carcinoma iib期宫颈癌放疗前血清survivin水平与临床疗效的关系
Pub Date : 2020-09-08 DOI: 10.15406/OGIJ.2020.11.00527
Romy Ade Putra, H. Susiarno, Ali Budi Harsono, Adji Kusumadjati
Background: Cervical carcinoma is the main malignant disease that causes death in women. Radiation is a therapy for cervical carcinoma. Radiation will induce apoptosis in carcinoma cells. Survivin as anti apoptosis will inhibit cervical carcinoma response to radiotherapy. For this reason, it is necessary to conduct a study that compares survivin levels in cervical carcinoma patients before radiotherapy with clinical response. Method: This study is an observational design with analytical cohort studies. The survivin serum level and mass size of 30 stage IIB cervical carcinoma patients were measured before radiotherapy, then the size of the mass was measured again after the patient completing radiotherapy. Mass size before and after radiotherapy is compared to determine the patient's clinical response to radiotherapy.The study was conducted at the Gynecology Oncology Clinic, Radiotherapy Department and Clinical Pathology Laboratory of Hasan Sadikin Hospital in January to July 2019. Result: Subjects with lower mean of survivin level, 111,789±2.47pg/mL produced a complete clinical response. Whereas subjects with a higher survivin level , 502,689±1.26pg/mL produced a partial clinical response. From the result of the T Test it was found that the mean of survivin serum levels were significant with p value of 0.029. Conclusion: The higher the survivin level before radiotherapy, the worse the clinical response to radiotherapy in patients with stage IIB cervical carcinoma.
背景:宫颈癌是导致妇女死亡的主要恶性疾病。放射治疗是宫颈癌的一种治疗方法。辐射可诱导癌细胞凋亡。Survivin抗凋亡作用可抑制宫颈癌对放疗的反应。因此,有必要对宫颈癌患者放疗前的survivin水平与临床反应进行比较研究。方法:本研究采用观察设计和分析队列研究。30例IIB期宫颈癌患者放疗前测定血清survivin水平及肿块大小,放疗结束后再次测定肿块大小。比较放疗前后的肿块大小,以确定患者对放疗的临床反应。该研究于2019年1月至7月在哈桑萨迪金医院妇科肿瘤诊所、放疗科和临床病理实验室进行。结果:survivin水平较低(111,789±2.47pg/mL)的患者临床完全缓解。而生存素水平较高的受试者,502,689±1.26pg/mL产生部分临床反应。T检验结果显示,血清survivin水平均值显著,p值为0.029。结论:放疗前survivin水平越高,IIB期宫颈癌患者放疗临床疗效越差。
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引用次数: 0
Assessment of different methods for diagnosis of Group B streptococci during pregnancy 妊娠期B群链球菌不同诊断方法的评价
Pub Date : 2020-09-07 DOI: 10.15406/OGIJ.2020.11.00526
Ahmed Rashwan
Objectives: To compare the different diagnostic techniques used to detect GBS colonization in pregnant women in late third trimester after thirty five weeks and to detect the frequency of GBS colonization among a sample of pregnant Egyptian women. Patients and methods: Vaginal swabs from the lower third of vagina were collected from 100 pregnant women in the late third trimester. Isolation of the organism by culture on selective media and confirmation by latex agglutination test and detection of CAMP factor by conventional PCR were compared. GBS isolates were tested by double disk diffusion method and D-zone test simultaneously for susceptibility to erythromycin and clindamycin and inducible clindamycin resistance for intrapartum antibiotic prophylaxis (IAP). Results: 25 participants (25%) were positive for GBS by culture in Lim broth with subculture onto TSA supplemented with 5% defibrinated sheep blood, while 75 participants (75%) were negative. Of the 25 GBS isolates, 19 (76%) were sensitive to erythromycin, 3 (12%) were intermediate and 3 (12%) were resistant. Of the 25 GBS isolates, 15 (60%) were sensitive to clindamycin, 2 (8%) were intermediate and 8 (32%) were resistant. Fourteen isolates (56%) were sensitive to both erythromycin and clindamycin whereas 3 (12%) were resistant to both (cMLSB). Latex agglutination test for GBS detection from the 24 hours incubated Lim broth was positive in 25 cases (25%). GBS was detected in 9 cases (9%) by the conventional PCR assay done directly from vaginal swabs specimens. Sensitivity, specificity, PPV and NPV for latex agglutination from the inoculated broth and PCR assay are 100%, 100%, 100%, 100% and 36%, 100%, 100%, 82.4% respectively. Latex agglutination test from the inoculated broth showed a statistically significant perfect agreement (100.0%) with culture with Kappa value 1.0 and 95% CI (1.0 – 1.0). PCR assay also showed a statistically significant but moderate agreement (84.0%) with culture with Kappa value 0.458 and 95% CI (0.253 – 0.662). Conclusion: Detection of GBS colonization by latex agglutination test from incubated selective broth directly is comparable to the gold standard (culture) as regards accuracy. PCR offers a rapid and highly specific method for detection of GBS colonization especially in intrapartum settings for administration of IAP in non-screened pregnant females; however, sensitivity is low resulting in a low NPV.
目的:比较用于检测35周后妊娠晚期孕妇GBS定植的不同诊断技术,并检测埃及孕妇样本中GBS定植的频率。患者和方法:收集100例妊娠晚期孕妇阴道下三分之一阴道拭子。比较了选择培养基分离、胶乳凝集试验确认和常规PCR检测CAMP因子的结果。采用双盘扩散法和d区试验同时检测GBS分离株对红霉素和克林霉素的敏感性和产时抗生素预防(IAP)诱导克林霉素耐药情况。结果:25名参与者(25%)在Lim肉汤中培养,并在添加5%去纤维羊血的TSA上继代培养,而75名参与者(75%)呈阴性。25株GBS分离株中,红霉素敏感19株(76%),中度3株(12%),耐药3株(12%)。25株GBS分离株中,15株(60%)对克林霉素敏感,2株(8%)为中度,8株(32%)耐药。14株(56%)对红霉素和克林霉素均敏感,3株(12%)对红霉素和克林霉素均耐药。培养24小时的林氏肉汤乳胶凝集试验检测GBS阳性25例(25%)。9例(9%)通过直接从阴道拭子标本中进行的常规PCR检测检测到GBS。接种肉汤凝集乳胶的敏感性、特异性、PPV和NPV分别为100%、100%、100%、100%和36%、100%、100%、82.4%。接种肉汤的乳胶凝集试验结果显示,与Kappa值1.0和95% CI(1.0 - 1.0)的培养结果完全吻合(100.0%),具有统计学意义。PCR检测结果与培养的Kappa值为0.458,95% CI为0.253 ~ 0.662,具有统计学意义,但一致性中等(84.0%)。结论:用乳胶凝集试验直接从培养的选择性肉汤中检测GBS定植的准确性与金标准(培养)相当。PCR提供了一种快速和高度特异性的方法来检测GBS定植,特别是在未筛查的孕妇中使用IAP的分娩环境中;然而,灵敏度低导致低净现值。
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引用次数: 3
Organ-preserving technologies and their effectiveness in patients with placenta accret 胎盘增生患者器官保存技术及其疗效
Pub Date : 2020-09-07 DOI: 10.15406/OGIJ.2020.11.00525
Djabbarova Yulduz Kasimovna, D. BabazhanovaSh, Lyubchich As
In recent years, in practical obstetrics, placental adherence into the myometrium, diagnosed after the birth of the fetus during caesarean section or in the 3rd period of labor, has become increasingly common. It causes massive bleeding, hysterectomy and maternal mortality. Purpose: To assess the outcome of childbirth with organ-preserving technology in cases of placenta accreta. Material and methods: 56 women in placenta accreta were observed and delivered for 2016-2018. 49 women delivered by Cesarean section and 7 women gave vaginal delivery. Two methods were used to preserve the uterus during placenta accreta: the first method -35 women who have laparotomy, a cesarean section with a section on the uterus above the scar and above the edge of the placenta, ligation of the uterine arteries, excision of the incremental area and metroplasty, imposition of compression sutures on the uterus. The second method -7 women after vaginal delivery left the whole or part of the placenta in the uterus - placenta in situ. The risk of placenta accreta was placenta previa, scar on the uterus, abortions in anamnesis, over 30 years of age third or more births. Results and discussion: From 35 pregnant women who underwent an organ-preserving procedure for caesarean section, 33 (94,3%) women managed to preserve the uterus, the remaining 2 (5,7%) women underwent hysterectomy Of 7 cases of placenta in situ, in 2 (28,6%) cases a hysterectomy was performed и. and uterus was preserved in 5 (71.4%) women. Conclusions: The effectiveness of improved organ-preserving technology to preserve the reproductive function of women with placenta accreta is high. In the group with the organ-preserving method with placenta, the volume of blood loss, the volume of transfusion of blood components is much lower than in the hysterectomy group.
近年来,在实际产科中,剖宫产或分娩第三期胎儿出生后诊断为胎盘粘附于子宫肌层的情况越来越普遍。它会导致大出血、子宫切除和产妇死亡。目的:探讨器官保存技术在胎盘增生中的应用效果。材料与方法:观察2016-2018年56例胎盘增生妇女的分娩情况。剖宫产49例,阴道分娩7例。在发生胎盘增生时,采用两种方法保存子宫:第一种方法-35例经剖腹手术的妇女,剖宫产,在疤痕和胎盘边缘以上的子宫进行剖宫产,结扎子宫动脉,切除增量区域并成形术,在子宫上施加压缩缝合线。第二种方法——7位妇女经阴道分娩后将全部或部分胎盘留在子宫内——原位胎盘。累赘胎盘的发生风险为前置胎盘、子宫瘢痕、遗忘流产、30岁以上生育三胎及以上。结果和讨论:在35例接受保留器官剖腹产手术的孕妇中,33例(94,3%)成功保留了子宫,其余2例(5,7%)接受了子宫切除术。7例原位胎盘,2例(28,6%)进行了子宫切除术。保留子宫5例(71.4%)。结论:改良器官保存技术对保留增生胎盘妇女生殖功能的有效性高。保留器官法合并胎盘组的失血量、输血量均明显低于子宫切除术组。
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引用次数: 0
Preadmission COVID-19 testing is an unnecessary use of resources 入院前COVID-19检测是对资源的不必要使用
Pub Date : 2020-09-03 DOI: 10.15406/OGIJ.2020.11.00524
C. Henderson, Janelle M. Jackman, S. Rezai
Background: Preadmission testing has been recommended nationwide across specialties in hospitals as a screening tool for detecting asymptomatic COVID-19 positive patients prior to procedures. Healthcare workers (HCW) have been using these results to decide whether or not the patient can have the procedure done as well as to determine whether HCW should use PPE. However, the majorities of these recommendations are from expert opinion and not evidenced based investigations. In the absence of actual data on the benefits of universal screening in asymptomatic patients, clinicians should really consider the possible pros and cons of this. We set out to review previously published research on COVID-19 testing to determine if universal screening can be justified with science. Conclusion: At this time, there is no evidence-based data for a universal screening program of asymptomatic patients in the absence of contact tracing. Universal PPE use, hand hygiene and the practice of personal prevention measures should be the major component in decreasing the spread of COVID-19 in the hospital setting. Keywords: 2019-nCoV, acute respiratory distress syndrome, autoimmune, COVID-19, healthcare worker, novel coronavirus 2019, pandemic, personal protective equipment, polymerase chain reaction, preadmission testing, SARS coronavirus, severe acute respiratory syndrome coronavirus 2, severe acute respiratory syndrome
背景:入院前检测已被推荐为全国各专科医院的筛查工具,用于在手术前检测无症状的COVID-19阳性患者。卫生保健工作者(HCW)一直在使用这些结果来决定患者是否可以进行手术,并确定HCW是否应该使用个人防护装备。然而,这些建议大多来自专家意见,而不是基于证据的调查。在缺乏关于无症状患者普遍筛查益处的实际数据的情况下,临床医生应该真正考虑可能的利弊。我们着手审查先前发表的关于COVID-19检测的研究,以确定普遍筛查是否有科学依据。结论:目前,在没有接触者追踪的情况下,尚无基于证据的无症状患者普遍筛查方案。普遍使用个人防护装备、手卫生和个人预防措施应成为减少COVID-19在医院环境中传播的主要组成部分。关键词:新型冠状病毒,急性呼吸窘迫综合征,自身免疫,COVID-19,医护人员,新型冠状病毒2019,大流行,个人防护装备,聚合酶链反应,入院前检测,SARS冠状病毒,严重急性呼吸综合征冠状病毒2,严重急性呼吸综合征
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引用次数: 0
The prevalence of uterine septum in polycystic ovarian syndrome (PCOS), a series of 49 cases 对多囊卵巢综合征(PCOS)中子宫间隔的患病率进行分析,共49例
Pub Date : 2020-09-02 DOI: 10.15406/OGIJ.2018.9.00355
F. Al-Rshoud, Rami Kilani, Fida Al-Asali, Ibrahim Alsharaydeh
Objective To estimate the prevalence of uterine septum in patients with polycystic ovarian syndrome(PCOS) that were investigated for infertility after failure to achieve pregnancy with ovulation induction in a highincidence area, such as Middle East. Design A prospective observational study Methods A 49 patients from a total of 172 patients seeking fertility advice at a specialised fertility clinic in Amman, Jordan, during the period of September 2017 to July 2018 with confirmed polycystic ovarian syndrome were screened for the presence of congenital uterine anomalies by a hysterosalpingogram(HSG). The anomalies were classified according to the American Fertility Society classification. If an anomaly was suspected a diagnostic laparoscopy and hysteroscopy were performed to confirm the diagnosis. Results 15 patients (31%) of the 49 patients with confirmed diagnosis of polycystic ovarian syndrome were confirmed to have uterine anomalies; 11 patients had a uterine septum, three patients had an arcuate uterus and one patient had a bicornuate uterus. Conclusion There is association between PCOS and uterine septum. This study hopes to enlighten infertility clinicians about the presence of uterine factor in PCOS patients (31%) and the need to screen for this congenital anomaly at their first consultation before embarking on the time-consuming and costly process of ovulation induction.
目的了解在中东等高发地区,多囊卵巢综合征(PCOS)诱导排卵致孕失败后不孕的患者中子宫间隔的发生率。方法选取2017年9月至2018年7月在约旦安曼一家专门生育诊所就诊的172例确诊多囊卵巢综合征患者中的49例,通过子宫输卵管造影(HSG)筛查是否存在先天性子宫异常。这些异常是根据美国生育学会的分类进行分类的。如果怀疑有异常,则进行诊断性腹腔镜和宫腔镜检查以确认诊断。结果49例确诊为多囊卵巢综合征的患者中有15例(31%)确诊为子宫异常;11例为子宫隔,3例为弓形子宫,1例为双角形子宫。结论PCOS与子宫间隔有一定的相关性。本研究希望能让不孕不育的临床医生了解多囊卵巢综合征(PCOS)患者(31%)子宫因子的存在,以及在进行耗时且昂贵的促排卵过程之前,在第一次咨询时筛查这种先天性异常的必要性。
{"title":"The prevalence of uterine septum in polycystic ovarian syndrome (PCOS), a series of 49 cases","authors":"F. Al-Rshoud, Rami Kilani, Fida Al-Asali, Ibrahim Alsharaydeh","doi":"10.15406/OGIJ.2018.9.00355","DOIUrl":"https://doi.org/10.15406/OGIJ.2018.9.00355","url":null,"abstract":"Objective \u0000To estimate the prevalence of uterine septum in patients with polycystic ovarian syndrome(PCOS) that \u0000were investigated for infertility after failure to achieve pregnancy with ovulation induction in a highincidence \u0000area, such as Middle East. \u0000Design \u0000A prospective observational study \u0000Methods \u0000A 49 patients from a total of 172 patients seeking fertility advice at a specialised fertility clinic in \u0000Amman, Jordan, during the period of September 2017 to July 2018 with confirmed polycystic ovarian \u0000syndrome were screened for the presence of congenital uterine anomalies by a \u0000hysterosalpingogram(HSG). The anomalies were classified according to the American Fertility Society \u0000classification. If an anomaly was suspected a diagnostic laparoscopy and hysteroscopy were performed \u0000to confirm the diagnosis. \u0000Results \u000015 patients (31%) of the 49 patients with confirmed diagnosis of polycystic ovarian syndrome were \u0000confirmed to have uterine anomalies; 11 patients had a uterine septum, three patients had an arcuate \u0000uterus and one patient had a bicornuate uterus. \u0000Conclusion \u0000There is association between PCOS and uterine septum. This study hopes to enlighten infertility \u0000clinicians about the presence of uterine factor in PCOS patients (31%) and the need to screen for this \u0000congenital anomaly at their first consultation before embarking on the time-consuming and costly \u0000process of ovulation induction.","PeriodicalId":19389,"journal":{"name":"Obstetrics & Gynecology International Journal","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74134388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is physical training important for women with polycystic ovary syndrome? 体育锻炼对多囊卵巢综合征的女性很重要吗?
Pub Date : 2020-08-18 DOI: 10.15406/OGIJ.2020.11.00523
V. Ribeiro, Rafael de Menezes Reis, G. Kogure, A. M. Zecchin-Oliveira, Higino Carlos Hahns Júnior
Polycystic Ovary Syndrome (PCOS) is an endocrine disorder 5 to 16% present in of women of reproductive age, which can suffer alterations in reproductive, cardiometabolic, hormonal and cardiovascular functions that can culminate in the development of other diseases. One of the treatments consists of improving life habits like physical exercise practice. Systematic reviews and studies in recent years have pointed out that the training protocols performed on women with PCOS were mostly conducted without control, randomization and personalization for this disease. Thus, the present study aims to investigate Pubmed database on the last year (between 05/31/2019 and 05/31/2020) if there are recent publications of randomized controlled trials (RCTs) that investigate the effects of physical training in women with PCOS.
多囊卵巢综合征(PCOS)是一种内分泌紊乱,占育龄妇女的5%至16%,可导致生殖、心脏代谢、激素和心血管功能的改变,最终导致其他疾病的发展。其中一种治疗方法包括改善生活习惯,比如体育锻炼。近年来的系统综述和研究指出,对多囊卵巢综合征女性进行的培训方案大多没有对该疾病进行控制、随机化和个性化。因此,本研究旨在调查最近一年(2019年5月31日至2020年5月31日)Pubmed数据库中是否有近期发表的随机对照试验(rct),这些试验研究了体育锻炼对PCOS女性的影响。
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引用次数: 0
Surgical oophorectomy or GnRH plus tamoxifen adjuvant therapy for breast cancer in low-risk premenopausal women: comparative benefits and risks 低危绝经前妇女乳腺癌手术切除或GnRH加他莫昔芬辅助治疗:比较获益和风险
Pub Date : 2020-08-12 DOI: 10.15406/ogij.2020.11.00522
R. Love
Background: While the combination of ovarian suppression or ablation treatment and tamoxifen or an aromatase inhibitor has been demonstrated to provide better outcomes as adjuvant therapies in premenopausal women with hormone receptor positive breast cancer, than treatment with tamoxifen alone, the details of applying these results in clinical practice, and the risks and benefits of the different ovarian treatments, particularly in women at lower risk for disease recurrence and death, have received limited attention. Methods: Details of clinical trials investigating combination hormonal adjuvant therapies, particularly with tamoxifen, were reviewed focusing on issues pertinent to assessment of risks and benefits in clinical practice. Results: Equivalent survival outcomes from surgical oophorectomy (SO) or GnRH agonist treatment plus tamoxifen, for which there are the most data at present, make the major decision issues for individual patients in choosing between these treatments: interest in future pregnancy, availability of data on secondary biological effects, capacity to adhere to a GnRH injection program for 5years, and ability to optimize dental hygiene (for taking bisphosphonate additional treatment). Other considerations applicable in individual patients include comparative secondary treatment effects, financial costs, and psychological impacts. Conclusion: If a patient with low-risk for recurrence breast cancer has interest in a future pregnancy, GnRH treatment is clearly appropriate. Otherwise, all major and minor risks of GnRH treatment are greater than those for SO treatment, when combined hormonal treatment with tamoxifen is taken.
背景:虽然卵巢抑制或消融治疗与他莫昔芬或芳香酶抑制剂联合治疗已被证明作为激素受体阳性乳腺癌绝经前妇女的辅助治疗,比单独使用他莫昔芬治疗提供更好的结果,但在临床实践中应用这些结果的细节,以及不同卵巢治疗的风险和益处,特别是在疾病复发和死亡风险较低的妇女中,受到的关注有限。方法:回顾研究激素联合辅助治疗的临床试验的细节,特别是与他莫昔芬,重点是在临床实践中评估风险和获益的相关问题。结果:手术卵巢切除术(SO)或GnRH激动剂加他莫昔芬治疗的等效生存结果,目前有最多的数据,为个体患者在选择这些治疗之间做出主要决策问题:对未来妊娠的兴趣,次要生物学效应数据的可用性,坚持GnRH注射计划5年的能力,以及优化牙齿卫生的能力(接受双膦酸盐额外治疗)。适用于个别患者的其他考虑因素包括比较二次治疗效果、经济成本和心理影响。结论:如果低复发风险的乳腺癌患者对未来妊娠有兴趣,GnRH治疗显然是合适的。否则,当激素联合他莫昔芬治疗时,GnRH治疗的所有主要和次要风险均大于SO治疗。
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引用次数: 0
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Obstetrics & Gynecology International Journal
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