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Economic Burden and Cost-Effectiveness of Management of Non-Infectious Uveitis: A Systematic Review. 非传染性葡萄膜炎治疗的经济负担和成本效益:系统综述。
IF 2.6 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-08 DOI: 10.1080/09273948.2025.2450472
Aswen Sriranganathan, Andrew Mihalache, Justin Grad, Rafael N Miranda, Tina Felfeli

Purpose: To evaluate the economic burden and cost-effectiveness of interventions and management of non-infectious uveitis (NIU).

Methods: A comprehensive search was conducted across Medline, Embase, and Scopus databases from inception to March 2023. Risk of bias assessments were conducted using the Joanna Briggs Institute critical appraisal tools.

Results: A total of 24 articles consisting of 16 economic burden studies (67%) and 9 cost-effectiveness or cost-utility studies (38%) met the inclusion criteria. Annual direct medical costs ranged from $16,428 to $134,135 USD 2023, with costs being 4.3 times higher for those with blindness compared to those without vision loss. Direct medical costs for corticosteroid, immunosuppressive, and biologic therapies were $19,497, $29.979, and $45,830, respectively. Indirect costs ranged from $806 to $57,170, with costs being 2.1 times higher for persistent NIU and 2.3 times higher for those with blindness. Annual medication and intervention costs ranged from $345 to $13,134, with prescription drug costs being 60% higher for blind patients compared to those with moderate vision loss. Overall, cost-effectiveness analyses show promise for treatments like adalimumab and certain implants, though the extent of economic benefit depends on price reductions and healthcare system variations. Varying parameters like willingness-to-pay (WTP) thresholds and input parameters further complicated comparability.

Conclusions: NIU poses a significant economic impact, particularly in patients with blindness and those on advanced therapies. While evidence is growing in Western countries like the US and UK, further research in non-westernized countries is warranted for a comprehensive, global understanding of the disease's economic burden.

目的:评价非传染性葡萄膜炎(NIU)干预和管理的经济负担和成本效益。方法:综合检索Medline、Embase和Scopus数据库,检索时间自成立至2023年3月。偏见风险评估使用乔安娜布里格斯研究所的关键评估工具进行。结果:共有24篇文章符合纳入标准,包括16项经济负担研究(67%)和9项成本-效果或成本-效用研究(38%)。每年的直接医疗费用从16,428美元到134,135美元不等,失明者的费用是无视力者的4.3倍。皮质类固醇、免疫抑制和生物疗法的直接医疗费用分别为19,497美元、29.979美元和45,830美元。间接成本从806美元到57,170美元不等,其中持续性NIU的成本高出2.1倍,失明的成本高出2.3倍。每年的药物和干预费用从345美元到13134美元不等,失明患者的处方药费用比中度视力丧失患者高60%。总体而言,成本效益分析显示阿达木单抗和某些植入物等治疗有希望,尽管经济效益的程度取决于价格降低和医疗系统的变化。诸如支付意愿(WTP)阈值和输入参数等参数的变化使可比性进一步复杂化。结论:NIU具有显著的经济影响,特别是对失明患者和接受先进治疗的患者。虽然在美国和英国等西方国家的证据越来越多,但为了全面、全面地了解这种疾病的经济负担,有必要在非西方化国家进行进一步的研究。
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引用次数: 0
Clinical Features and Predictors of Treatment Outcome in Patients with Ocular Tuberculosis from the Netherlands and Indonesia: The OculaR TB in Low versus High Endemic Countries (ORTEC) Study. 荷兰和印度尼西亚眼结核患者的临床特征和治疗结果预测因素:低流行率国家与高流行率国家眼结核(ORTEC)研究。
IF 2.6 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-01 Epub Date: 2024-05-31 DOI: 10.1080/09273948.2024.2359614
Ikhwanuliman Putera, Josianne C E M Ten Berge, Alberta A H J Thiadens, Willem A Dik, Rupesh Agrawal, P Martin van Hagen, Rina La Distia Nora, Saskia M Rombach

Purpose: To describe and compare clinical features, treatment approaches, and treatment outcomes of ocular tuberculosis (OTB) patients in the Netherlands, a low tuberculosis (TB)-endemic country, and Indonesia, a high TB-endemic country. We also aimed to identify predictors of treatment outcomes.

Methods: A medical chart review of 339 OTB patients (n = 93 from the Netherlands and n = 246 from Indonesia) was performed. The primary outcome was response to treatment, whether with or without anti-tubercular treatment, after six months of treatment initiation (good versus poor responders).

Results: Indonesian OTB patients displayed a higher prevalence of chest radiograph findings indicative of TB infection (p < 0.001) and concurrent active systemic TB (p = 0.011). Indonesian cohort exhibited a more acute and severe disease profile, including uveitis duration ≤ 3 months (p < 0.001), blindness (p < 0.001), anterior chamber (AC) cells ≥ 2+ (p < 0.001), and posterior synechiae (p < 0.001). Overall proportions of good responders to treatment were 67.6% in the Netherlands and 71.5% in Indonesia. Presence of AC cell ≥ 2+ (adjusted odds ratio (aOR): 2.12, 95% CI: 1.09-4.14), choroidal lesions other than serpiginous-like choroiditis (SLC) or tuberculoma (aOR: 4.47, 95% CI: 1.18-16.90), and retinal vasculitis (aOR: 2.32, 95% CI: 1.10-4.90) at baseline were predictors for poor response to treatment.

Conclusions: Despite a more severe initial clinical presentation in the Indonesian cohort, the overall treatment outcomes of OTB was comparable in both cohorts. Three baseline clinical features were identified as predictors of treatment outcomes.

目的:描述并比较结核病(TB)低流行国家荷兰和结核病高流行国家印度尼西亚的眼部结核病(OTB)患者的临床特征、治疗方法和治疗效果。我们还旨在确定治疗结果的预测因素:我们对 339 名 OTB 患者(荷兰 93 人,印度尼西亚 246 人)进行了病历回顾。主要结果是开始治疗 6 个月后的治疗反应,无论是否接受抗结核治疗(反应好与反应差):结果:印尼的 OTB 患者胸片显示结核感染的发病率更高(P = 0.011)。印尼队列中的患者病情更急、更严重,包括葡萄膜炎病程不超过 3 个月(p p p p 结论:尽管印尼 OTB 患者最初的临床表现更严重,但他们的临床表现比印尼患者更积极:尽管印尼组的初始临床表现更为严重,但两组患者的总体治疗效果相当。有三个基线临床特征可预测治疗结果。
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引用次数: 0
Letter to the Editor, "Drug Retention Time of Immunosuppressive Therapy in Behcet's Uveitis." 致编辑的信,"白塞氏葡萄膜炎免疫抑制疗法的药物保留时间"。
IF 2.6 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-01 Epub Date: 2024-07-25 DOI: 10.1080/09273948.2024.2378360
Geetha Shanmugam
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引用次数: 0
Clinical Characteristics of HLA-B27-Associated Anterior Uveitis in a Finnish Population-Based Cohort. 芬兰人群中 HLA-B27 相关前葡萄膜炎的临床特征
IF 2.6 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-01 Epub Date: 2024-06-06 DOI: 10.1080/09273948.2024.2360593
Aada Leino, Roosa Pesälä, Mira Siiskonen, Pasi Ohtonen, Nina Hautala

Purpose: To evaluate the clinical characteristics, treatment outcomes and ocular complications in patients with HLA-B27-associated AU compared to those without HLA-B27.

Methods: From the population-based data of all adult patients with AU during 2009-2020 (n = 413), 241 patients tested for HLA-B27 were included. Age of the initial onset, gender, etiology, course of uveitis, visual outcomes and complications were studied.

Results: 170 patients (71%) were HLA-B27+ and 71 (29%) HLA-B27-. Mean age at uveitis onset was 37 ± 13 in HLA-B27+ (95% CI, 35.4-39.3) and 43 ± 14 (95% CI, 40.3-46.4) in HLA-B27- patients (p = 0.001). Male:female ratio was 1.1:1 among HLA-B27+ and 0.58:1 (p = 0.024) in HLA-B27- patients. Most patients, 63% in HLA-B27+ and 68% in HLA-B27- had chronic uveitis. Recurrences were noted in 31% in HLA-B27+ group compared to 13%in HLA-B27-. 51% and 17% of HLA-B27+ and HLA-B27- patients, respectively, had systemic disease-associated uveitis. Etiology was Idiopathic in 44% and 69% of HLA-B27+ and HLA-B27- patients, respectively (p < 0.001). After the follow-up, +2 and -4 ETDRS letters changes were noted in HLA-B27+ and HLA-B27- patients (p = 0.005). Ocular complications developed in 43% and 47%, and surgical treatment of complications was required in 20% and 33% of patients in HLA-B27+ and HLA-B27- patients (p = 0.009). 1% (HLA-B27+) and 3% (HLA-B27-) developed visual impairment.

Conclusion: Our results highlight the differences in the age of uveitis onset, gender distribution, course of uveitis, etiology, and treatment outcomes in HLA-B27+ and HLA-B27-uveitis. HLA-B27 seems to be associated with younger age at uveitis onset, more recurrences, systemic diseases, and better treatment outcomes with less complications.

目的:评估HLA-B27相关AU患者与无HLA-B27患者的临床特征、治疗效果和眼部并发症:从2009-2020年期间所有AU成年患者(n = 413)的人群数据中,纳入了241名接受过HLA-B27检测的患者。研究了初次发病的年龄、性别、病因、葡萄膜炎病程、视觉结果和并发症:HLA-B27+患者发病时的平均年龄为37 ± 13(95% CI,35.4-39.3)岁,HLA-B27-患者发病时的平均年龄为43 ± 14(95% CI,40.3-46.4)岁(P = 0.001)。HLA-B27+患者的男女比例为1.1:1,HLA-B27-患者的男女比例为0.58:1(p = 0.024)。大多数患者(63%的HLA-B27+患者和68%的HLA-B27-患者)患有慢性葡萄膜炎。HLA-B27+和HLA-B27-患者中分别有51%和17%患有系统性疾病相关的葡萄膜炎。HLA-B27+和HLA-B27-患者中分别有44%和69%的病因是特发性的(P = 0.005)。43%和47%的患者出现眼部并发症,20%和33%的HLA-B27+和HLA-B27-患者需要手术治疗并发症(P = 0.009)。1%(HLA-B27+)和3%(HLA-B27-)的患者出现视力障碍:我们的研究结果突显了HLA-B27+和HLA-B27-葡萄膜炎患者在发病年龄、性别分布、葡萄膜炎病程、病因和治疗效果方面的差异。HLA-B27似乎与葡萄膜炎发病年龄较小、复发率较高、全身性疾病较多、治疗效果较好、并发症较少有关。
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引用次数: 0
Transient Bacillary Layer Detachment During the Disease Course of Primary Vitreoretinal Lymphoma. 原发性玻璃体视网膜淋巴瘤病程中短暂的浆液层脱落
IF 2.6 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-01 Epub Date: 2024-06-05 DOI: 10.1080/09273948.2024.2359627
Giuseppe Casalino, Alessia Malerba, Sonia Fabris, Niccolò Bolli, Giorgio Alberto Croci, Marco Pellegrini, Francesca Gaia Rossi, Chiara Mapelli, Francesco Viola

Purpose: To report the clinical course and the retinal imaging features of a case of cytology-proven primary vitreoretinal lymphoma (PVRL) presenting with a transient bacillary layer detachment (BALAD) during the disease course.

Methods: Observational case report.

Results: A 50 year-old woman was referred to us with a 2-month history of vitritis in both eyes, poorly responding to oral prednisolone. After discontinuation of oral prednisolone, worsening of vitritis and the appearance of multiple creamy-like subretinal infiltrates in the mid-peripheral retina of both eyes, along with the exclusion of common causes of intermediate/posterior uveitis, made us consider PVRL. Aqueous humor sampling detected MYD88 L265P mutation, and subsequent diagnostic pars plana vitrectomy in the left eye yielded a positive cytology for large B cell lymphoma consistent with PVRL. During the disease course, optical coherence tomography of the macula showed a BALAD in the right eye, which resolved during follow-up.

Conclusion: Our case indicates that BALAD is a possible rare manifestation of PVRL, and this should be considered in the differential diagnosis process in order to avoid diagnostic delays.

目的:报告一例经细胞学证实的原发性玻璃体视网膜淋巴瘤(PVRL)在病程中出现一过性纤维层脱离(BALAD)的临床过程和视网膜成像特征:方法:观察性病例报告:一位50岁的妇女因双眼玻璃体炎2个月,对口服泼尼松龙反应差而转诊至我院。停用口服泼尼松龙后,玻璃体炎恶化,双眼视网膜中周出现多发性奶油样视网膜下浸润,同时排除了中/后葡萄膜炎的常见病因,这让我们不得不考虑 PVRL。房水取样检测到 MYD88 L265P 突变,随后对左眼进行了诊断性玻璃体旁切除术,结果显示大 B 细胞淋巴瘤细胞学阳性,与 PVRL 相符。在病程中,黄斑部光学相干断层扫描显示右眼有一个 BALAD,但在随访过程中该症状消失了:我们的病例表明,BALAD可能是PVRL的一种罕见表现,在鉴别诊断过程中应考虑到这一点,以免延误诊断。
{"title":"Transient Bacillary Layer Detachment During the Disease Course of Primary Vitreoretinal Lymphoma.","authors":"Giuseppe Casalino, Alessia Malerba, Sonia Fabris, Niccolò Bolli, Giorgio Alberto Croci, Marco Pellegrini, Francesca Gaia Rossi, Chiara Mapelli, Francesco Viola","doi":"10.1080/09273948.2024.2359627","DOIUrl":"10.1080/09273948.2024.2359627","url":null,"abstract":"<p><strong>Purpose: </strong>To report the clinical course and the retinal imaging features of a case of cytology-proven primary vitreoretinal lymphoma (PVRL) presenting with a transient bacillary layer detachment (BALAD) during the disease course.</p><p><strong>Methods: </strong>Observational case report.</p><p><strong>Results: </strong>A 50 year-old woman was referred to us with a 2-month history of vitritis in both eyes, poorly responding to oral prednisolone. After discontinuation of oral prednisolone, worsening of vitritis and the appearance of multiple creamy-like subretinal infiltrates in the mid-peripheral retina of both eyes, along with the exclusion of common causes of intermediate/posterior uveitis, made us consider PVRL. Aqueous humor sampling detected <i>MYD88</i> L265P mutation, and subsequent diagnostic pars plana vitrectomy in the left eye yielded a positive cytology for large B cell lymphoma consistent with PVRL. During the disease course, optical coherence tomography of the macula showed a BALAD in the right eye, which resolved during follow-up.</p><p><strong>Conclusion: </strong>Our case indicates that BALAD is a possible rare manifestation of PVRL, and this should be considered in the differential diagnosis process in order to avoid diagnostic delays.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"180-185"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Spectrum of Presumed Tubercular Uveitis in a Referral Eye Clinic in Qatar. 卡塔尔一家眼科转诊诊所中推测的结核性葡萄膜炎的范围。
IF 2.6 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-01 Epub Date: 2024-07-09 DOI: 10.1080/09273948.2024.2368668
Rehab Sabry Helal, Sonia Attia, Zamzam Mohammed Al-Baker, Sameer Al-Shweiki, Rami Abu Sbeit, Mohammed Abukhattab, Nabeel Abdulla, Moncef Khairallah

Purpose: To analyze the clinical spectrum of patients with presumed tubercular uveitis in a referral eye clinic in Qatar.

Methods: We retrospectively reviewed the clinical records of 50 patients (80 eyes) diagnosed with presumed ocular tuberculosis who presented to the uveitis clinic, department of Ophthalmology Hamad Medical Corporation, Qatar, from January 2014 till December 2019.

Results: Mean age at presentation was 34.5 ± 9.3 years. Forty one patients were males (82%) and 30 patients had bilateral involvement (60%). Forty eyes (50%) had posterior uveitis, 21 eyes (26.3%) intermediate uveitis, 11 eyes (13.7%) panuveitis, and 8 eyes (10%) anterior uveitis. Ocular findings included vitritis in 82.5% of eyes, retinal vasculitis in 46.3% (92% of which were occlusive in nature), multifocal choroiditis in 18.8%, serpiginous-like choroiditis in 11.3%, Most common complications at presentation or during follow-up included macular edema in 32 eyes (40%), preretinal or optic disc neovascularization in 29 eyes (36.3%) and vitreous hemorrhage in 17 eyes (21.3%). Anti-tubercular treatment was provided to 46 patients (92%). Systemic corticosteroids and corticosteroid sparing agents were associated, respectively, in 39 patients (78%) and 14 patients (28%). After 1 year of follow up, inflammation was controlled, with a significant improvement in visual acuity (p < 0.0001).

Conclusions: In Qatar, tubercular uveitis has a broad spectrum of ocular features, with posterior and intermediate uveitis being the most common anatomic forms. Vitritis, multifocal choroiditis without or with a serpiginous-like pattern, and occlusive retinal vasculitis are the most common ocular findings. Main sight-threatening ocular complications are macular edema, posterior segment neovascularization, and vitreous hemorrhage.

目的:分析卡塔尔一家眼科转诊诊所推测的结核性葡萄膜炎患者的临床表现:我们回顾性审查了自 2014 年 1 月至 2019 年 12 月期间在卡塔尔哈马德医疗公司眼科部葡萄膜炎诊所就诊的 50 名被诊断为推测眼结核患者(80 只眼)的临床记录:平均就诊年龄为(34.5 ± 9.3)岁。41名患者为男性(82%),30名患者为双侧受累(60%)。40眼(50%)患有后葡萄膜炎,21眼(26.3%)患有中间葡萄膜炎,11眼(13.7%)患有泛葡萄膜炎,8眼(10%)患有前葡萄膜炎。最常见的并发症包括黄斑水肿(32 眼,占 40%)、视网膜前或视盘新生血管(29 眼,占 36.3%)和玻璃体出血(17 眼,占 21.3%)。46 名患者(92%)接受了抗结核治疗。39名患者(78%)和14名患者(28%)分别使用了全身皮质类固醇和皮质类固醇疏松剂。随访 1 年后,炎症得到控制,视力明显改善(P 结论):在卡塔尔,结核性葡萄膜炎具有广泛的眼部特征,后葡萄膜炎和中间葡萄膜炎是最常见的解剖形式。玻璃体炎、多灶性脉络膜炎(不伴有或伴有蛇皮样形态)和闭塞性视网膜血管炎是最常见的眼部表现。危及视力的主要眼部并发症是黄斑水肿、后节新生血管和玻璃体出血。
{"title":"The Spectrum of Presumed Tubercular Uveitis in a Referral Eye Clinic in Qatar.","authors":"Rehab Sabry Helal, Sonia Attia, Zamzam Mohammed Al-Baker, Sameer Al-Shweiki, Rami Abu Sbeit, Mohammed Abukhattab, Nabeel Abdulla, Moncef Khairallah","doi":"10.1080/09273948.2024.2368668","DOIUrl":"10.1080/09273948.2024.2368668","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the clinical spectrum of patients with presumed tubercular uveitis in a referral eye clinic in Qatar.</p><p><strong>Methods: </strong>We retrospectively reviewed the clinical records of 50 patients (80 eyes) diagnosed with presumed ocular tuberculosis who presented to the uveitis clinic, department of Ophthalmology Hamad Medical Corporation, Qatar, from January 2014 till December 2019.</p><p><strong>Results: </strong>Mean age at presentation was 34.5 ± 9.3 years. Forty one patients were males (82%) and 30 patients had bilateral involvement (60%). Forty eyes (50%) had posterior uveitis, 21 eyes (26.3%) intermediate uveitis, 11 eyes (13.7%) panuveitis, and 8 eyes (10%) anterior uveitis. Ocular findings included vitritis in 82.5% of eyes, retinal vasculitis in 46.3% (92% of which were occlusive in nature), multifocal choroiditis in 18.8%, serpiginous-like choroiditis in 11.3%, Most common complications at presentation or during follow-up included macular edema in 32 eyes (40%), preretinal or optic disc neovascularization in 29 eyes (36.3%) and vitreous hemorrhage in 17 eyes (21.3%). Anti-tubercular treatment was provided to 46 patients (92%). Systemic corticosteroids and corticosteroid sparing agents were associated, respectively, in 39 patients (78%) and 14 patients (28%). After 1 year of follow up, inflammation was controlled, with a significant improvement in visual acuity (<i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>In Qatar, tubercular uveitis has a broad spectrum of ocular features, with posterior and intermediate uveitis being the most common anatomic forms. Vitritis, multifocal choroiditis without or with a serpiginous-like pattern, and occlusive retinal vasculitis are the most common ocular findings. Main sight-threatening ocular complications are macular edema, posterior segment neovascularization, and vitreous hemorrhage.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"105-112"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Word from the Editors. 编辑们的一句话。
IF 2.6 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.1080/09273948.2025.2450936
Derrick P Smit, Jennifer E Thorne, Ilknur Tugal-Tutkun
{"title":"A Word from the Editors.","authors":"Derrick P Smit, Jennifer E Thorne, Ilknur Tugal-Tutkun","doi":"10.1080/09273948.2025.2450936","DOIUrl":"10.1080/09273948.2025.2450936","url":null,"abstract":"","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"1"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of IL6R and IL10 Gene Polymorphisms with Susceptibility to Ankylosing Spondylitis with or without Acute Anterior Uveitis. IL6R和IL10基因多态性与伴有或不伴有急性前葡萄膜炎的强直性脊柱炎易感性的关系
IF 2.6 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-01 Epub Date: 2024-02-12 DOI: 10.1080/09273948.2024.2309279
Li Lin, Fuzhen Li, Haixin Fang, Pengyi Zhou, Jiankang Shan, Kunpeng Xie, Bo Jin, Haiyan Zhu, Xuemin Jin, Liping Du, Peizeng Yang

Background: This research aims to explore the associations between ten candidate single nucleotide polymorphisms (SNPs) on Interleukin-6 receptor (IL6R) and Interleukin-10 (IL10) genes and ankylosing spondylitis (AS) patients with or without acute anterior uveitis (AAU).

Methods: This study involved a case-control approach that examined 354 cases with AS and AAU, 377 AS cases without AAU, and 918 healthy controls. Genotyping of ten SNPs of IL10 and IL6R genes was performed using iPLEX Gold genotyping method. The allele and genotype frequencies of cases and healthy individuals were contrasted using the chi-square test. The IL10 mRNA level in various IL10 genotypes was tested using real-time PCR.

Results: Two loci associated with AS with AAU were identified: IL10//rs3790622 (OR = 0.664; 95%CI = 0.503-0.878; Pc = 0.038); IL10//rs3021094 (OR = 1.365; 95%CI = 1.110-1.679; Pc = 0.032). The other eight loci located on IL10 and IL6R did not show significant associations with the diseases. Additionally, as shown by functional experiments, there was no correlation between the mRNA expression of IL10 and various genotypes.

Conclusion: Our study suggests that the IL10 gene contributes to the susceptibility of the Chinese population to AS with AAU.

研究背景本研究旨在探讨白细胞介素-6受体(IL6R)和白细胞介素-10(IL10)基因上的10个候选单核苷酸多态性(SNPs)与伴有或不伴有急性前葡萄膜炎(AAU)的强直性脊柱炎(AS)患者之间的关联:本研究采用病例对照方法,对354例强直性脊柱炎和AAU患者、377例强直性脊柱炎而无AAU患者以及918例健康对照者进行了研究。采用iPLEX Gold基因分型方法对IL10和IL6R基因的10个SNPs进行了基因分型。采用卡方检验对比了病例和健康人的等位基因和基因型频率。使用实时 PCR 检测了不同 IL10 基因型的 IL10 mRNA 水平:结果:发现了两个与AS伴AAU相关的基因位点:IL10//rs3790622(OR=0.664;95%CI=0.503-0.878;Pc=0.038);IL10//rs3021094(OR=1.365;95%CI=1.110-1.679;Pc=0.032)。位于 IL10 和 IL6R 上的其他 8 个基因位点与疾病无显著关联。此外,功能实验表明,IL10 的 mRNA 表达与各种基因型之间没有相关性:我们的研究表明,IL10 基因是中国人患强直性脊柱炎和 AAU 的易感基因。
{"title":"Associations of <i>IL6R</i> and <i>IL10</i> Gene Polymorphisms with Susceptibility to Ankylosing Spondylitis with or without Acute Anterior Uveitis.","authors":"Li Lin, Fuzhen Li, Haixin Fang, Pengyi Zhou, Jiankang Shan, Kunpeng Xie, Bo Jin, Haiyan Zhu, Xuemin Jin, Liping Du, Peizeng Yang","doi":"10.1080/09273948.2024.2309279","DOIUrl":"10.1080/09273948.2024.2309279","url":null,"abstract":"<p><strong>Background: </strong>This research aims to explore the associations between ten candidate single nucleotide polymorphisms (SNPs) on Interleukin-6 receptor (IL6R) and Interleukin-10 (IL10) genes and ankylosing spondylitis (AS) patients with or without acute anterior uveitis (AAU).</p><p><strong>Methods: </strong>This study involved a case-control approach that examined 354 cases with AS and AAU, 377 AS cases without AAU, and 918 healthy controls. Genotyping of ten SNPs of IL10 and IL6R genes was performed using iPLEX Gold genotyping method. The allele and genotype frequencies of cases and healthy individuals were contrasted using the chi-square test. The IL10 mRNA level in various IL10 genotypes was tested using real-time PCR.</p><p><strong>Results: </strong>Two loci associated with AS with AAU were identified: IL10//rs3790622 (OR = 0.664; 95%CI = 0.503-0.878; Pc = 0.038); IL10//rs3021094 (OR = 1.365; 95%CI = 1.110-1.679; Pc = 0.032). The other eight loci located on IL10 and IL6R did not show significant associations with the diseases. Additionally, as shown by functional experiments, there was no correlation between the mRNA expression of IL10 and various genotypes.</p><p><strong>Conclusion: </strong>Our study suggests that the IL10 gene contributes to the susceptibility of the Chinese population to AS with AAU.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"2-9"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sphingomonas paucimobilis: Navigating from Recurrent Hypopyon Anterior Uveitis to Endogenous Endophthalmitis: A Case Report. 鞘氨单胞菌(Sphingomonas paucimobilis):从复发性下腔前葡萄膜炎到内源性眼内炎的导航:病例报告。
IF 2.6 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-01 Epub Date: 2024-06-10 DOI: 10.1080/09273948.2024.2363487
Manishikaa Thamotharan, Ramavath Shree Keerti, A R Anand, Jyotirmay Biswas

Purpose: To report a case of endogenous endophthalmitis caused by Sphingomonas paucimobilis in a young male.

Materials and methods: A retrospective case report.

Results: A 25-year-old male presented with reduced vision in the right eye and recurrent past episodes of hypopyon uveitis. The right eye had vision of counting fingers close to the face with cells, flare, and hypopyon in the anterior chamber with vitritis and exudates in the fundus. Blood investigations for tuberculosis, syphilis, toxoplasma, sarcoidosis, RA, ANA, HLA B27, and HLA B29 were negative. Anterior chamber tap investigations for herpes simplex viruses, varicella-zoster virus, cytomegalovirus, and toxoplasma, as well as Mycobacterium tuberculosis, yielded negative results. Ultrasound B-scan revealed a moderate number of low-reflective dot echoes in the vitreous, along with a few membranous echoes suggestive of vitritis. Blood culture and urine culture were negative. Since there was progressive deterioration, diagnostic and therapeutic vitrectomy was done with intravitreal antibiotics. The culture of the vitreous sample grew Sphingomonas paucimobilis. In the post-operative period, the patient developed retinal detachment, and re-surgery was done with a lensectomy, and the vision improved to 6/18 with contact lenses in the follow-up.

Conclusion: This case report describes the distinct occurrence of endogenous endophthalmitis in an immunocompetent young male, which was previously reported only in peripartum cases. The clinical course is characterized by masquerading symptoms and recurrent episodes, despite the organism being of low virulence.

目的:报告一例由Sphingomonas paucimobilis引起的年轻男性内源性眼内炎病例:回顾性病例报告:结果:一名25岁的男性因右眼视力下降和过去反复发作的低眼压葡萄膜炎而就诊。右眼的视力为数手指近脸部,前房有细胞、耀斑和视网膜下腔,眼底有玻璃体炎和渗出物。结核、梅毒、弓形虫、类肉瘤病、RA、ANA、HLA B27 和 HLA B29 的血液检查均为阴性。单纯疱疹病毒、水痘-带状疱疹病毒、巨细胞病毒和弓形虫以及结核分枝杆菌的前房穿刺检查结果均为阴性。超声波 B 型扫描显示,玻璃体内有中等数量的低反射点状回声,还有一些膜状回声,提示有玻璃体炎。血培养和尿培养均为阴性。由于病情逐渐恶化,医生对其进行了诊断性和治疗性玻璃体切除术,并在玻璃体内注射了抗生素。玻璃体样本培养出了白膜单胞菌(Sphingomonas paucimobilis)。术后,患者出现视网膜脱离,再次手术时进行了晶状体切除术,随访期间戴隐形眼镜后视力提高到 6/18:本病例报告描述了在一名免疫功能正常的年轻男性身上发生的内源性眼内炎,这种情况以前只在围产期病例中报道过。尽管该病原体毒力较低,但其临床病程的特点是伪装症状和反复发作。
{"title":"Sphingomonas paucimobilis: Navigating from Recurrent Hypopyon Anterior Uveitis to Endogenous Endophthalmitis: A Case Report.","authors":"Manishikaa Thamotharan, Ramavath Shree Keerti, A R Anand, Jyotirmay Biswas","doi":"10.1080/09273948.2024.2363487","DOIUrl":"10.1080/09273948.2024.2363487","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of endogenous endophthalmitis caused by Sphingomonas paucimobilis in a young male.</p><p><strong>Materials and methods: </strong>A retrospective case report.</p><p><strong>Results: </strong>A 25-year-old male presented with reduced vision in the right eye and recurrent past episodes of hypopyon uveitis. The right eye had vision of counting fingers close to the face with cells, flare, and hypopyon in the anterior chamber with vitritis and exudates in the fundus. Blood investigations for tuberculosis, syphilis, toxoplasma, sarcoidosis, RA, ANA, HLA B27, and HLA B29 were negative. Anterior chamber tap investigations for herpes simplex viruses, varicella-zoster virus, cytomegalovirus, and toxoplasma, as well as Mycobacterium tuberculosis, yielded negative results. Ultrasound B-scan revealed a moderate number of low-reflective dot echoes in the vitreous, along with a few membranous echoes suggestive of vitritis. Blood culture and urine culture were negative. Since there was progressive deterioration, diagnostic and therapeutic vitrectomy was done with intravitreal antibiotics. The culture of the vitreous sample grew Sphingomonas paucimobilis. In the post-operative period, the patient developed retinal detachment, and re-surgery was done with a lensectomy, and the vision improved to 6/18 with contact lenses in the follow-up.</p><p><strong>Conclusion: </strong>This case report describes the distinct occurrence of endogenous endophthalmitis in an immunocompetent young male, which was previously reported only in peripartum cases. The clinical course is characterized by masquerading symptoms and recurrent episodes, despite the organism being of low virulence.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"158-160"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Patterns of Sarcoidosis Patients with and without Uveitis: Insights from a Dutch Sarcoidosis Centre. 患有和未患有葡萄膜炎的肉样瘤病患者的临床模式:来自荷兰肉样瘤病中心的启示。
IF 2.6 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2025-01-01 Epub Date: 2024-06-25 DOI: 10.1080/09273948.2024.2369931
Sanela Kuč, Petal Wijnen, Roel Erckens, Marlies Gijs, Carroll A B Webers, Otto Bekers, Marjolein Drent

Purpose: Uveitis is a common ocular manifestation in individuals with sarcoidosis, a multisystem inflammatory disorder. This study aimed to explore clinical and genetic factors associated with the presence or absence of uveitis in sarcoidosis patients.

Methods: Total 625 Dutch sarcoidosis patients were included. Among these, 170 underwent ophthalmic examination, and 61 were diagnosed with uveitis. Demographic and clinical data, including age, gender, race, biopsy status, chest radiography findings, TNF-α inhibitor treatment, and uveitis classification were collected retrospectively from medical records. Genetic data was available for HLA haplotypes, TNF-α G-308A, and BTNL2 G16071A polymorphisms.

Results: The majority of the patients presented with bilateral uveitis (80.3%). The proportion of women was higher in the uveitis group compared to the non-uveitis group (67.2% and 47.7%; p = 0.014). Pulmonary involvement (chest radiographic stage II-III) was significantly lower in patients with uveitis (36.1% versus 64.2%; p < 0.001). Patients with uveitis were more often treated with TNF-α inhibitors (67.2% versus 29.4%; p < 0.001) and the outcome was better compared with the non-uveitis group, 92% vs 68%, responders (p < 0.012). Uveitis patients treated with TNF-α inhibitors (either adalimumab or infliximab) were more likely to suffer from intermediate or posterior uveitis than anterior uveitis. Genetic analysis identified a significant association between the BTNL2 G16071A GG genotype and uveitis (p = 0.012).

Conclusion: This study highlights distinctive demographic, clinical and genetic features associated with uveitis in sarcoidosis patients. Ocular sarcoidosis was more prevalent in women. Further research is warranted to explore the implications of these findings for treatment strategies and prognostic assessments.

目的:葡萄膜炎是肉样瘤病这种多系统炎症性疾病患者常见的眼部表现。本研究旨在探讨与肉样瘤病患者是否患有葡萄膜炎相关的临床和遗传因素:方法:共纳入 625 名荷兰肉样瘤病患者。方法:共纳入 625 名荷兰肉样瘤病患者,其中 170 人接受了眼科检查,61 人被确诊为葡萄膜炎。我们从病历中回顾性地收集了人口统计学和临床数据,包括年龄、性别、种族、活检情况、胸片检查结果、TNF-α抑制剂治疗情况和葡萄膜炎分类。遗传数据包括HLA单倍型、TNF-α G-308A和BTNL2 G16071A多态性:大多数患者都患有双侧葡萄膜炎(80.3%)。葡萄膜炎组的女性比例高于非葡萄膜炎组(67.2% 和 47.7%;P = 0.014)。葡萄膜炎患者的肺部受累程度(胸部放射学检查 II-III 期)明显较低(36.1% 对 64.2%;P P BTNL2 G16071A GG 基因型和葡萄膜炎(P = 0.012):本研究强调了肉样瘤病患者与葡萄膜炎相关的独特人口、临床和遗传特征。女性患眼部肉样瘤病的比例更高。我们有必要进一步研究这些发现对治疗策略和预后评估的影响。
{"title":"Clinical Patterns of Sarcoidosis Patients with and without Uveitis: Insights from a Dutch Sarcoidosis Centre.","authors":"Sanela Kuč, Petal Wijnen, Roel Erckens, Marlies Gijs, Carroll A B Webers, Otto Bekers, Marjolein Drent","doi":"10.1080/09273948.2024.2369931","DOIUrl":"10.1080/09273948.2024.2369931","url":null,"abstract":"<p><strong>Purpose: </strong>Uveitis is a common ocular manifestation in individuals with sarcoidosis, a multisystem inflammatory disorder. This study aimed to explore clinical and genetic factors associated with the presence or absence of uveitis in sarcoidosis patients.</p><p><strong>Methods: </strong>Total 625 Dutch sarcoidosis patients were included. Among these, 170 underwent ophthalmic examination, and 61 were diagnosed with uveitis. Demographic and clinical data, including age, gender, race, biopsy status, chest radiography findings, TNF-α inhibitor treatment, and uveitis classification were collected retrospectively from medical records. Genetic data was available for HLA haplotypes, <i>TNF-α</i> G-308A, and <i>BTNL2</i> G16071A polymorphisms.</p><p><strong>Results: </strong>The majority of the patients presented with bilateral uveitis (80.3%). The proportion of women was higher in the uveitis group compared to the non-uveitis group (67.2% and 47.7%; <i>p</i> = 0.014). Pulmonary involvement (chest radiographic stage II-III) was significantly lower in patients with uveitis (36.1% versus 64.2%; <i>p</i> < 0.001). Patients with uveitis were more often treated with TNF-α inhibitors (67.2% versus 29.4%; <i>p</i> < 0.001) and the outcome was better compared with the non-uveitis group, 92% vs 68%, responders (<i>p</i> < 0.012). Uveitis patients treated with TNF-α inhibitors (either adalimumab or infliximab) were more likely to suffer from intermediate or posterior uveitis than anterior uveitis. Genetic analysis identified a significant association between the <i>BTNL2</i> G16071A GG genotype and uveitis (<i>p</i> = 0.012).</p><p><strong>Conclusion: </strong>This study highlights distinctive demographic, clinical and genetic features associated with uveitis in sarcoidosis patients. Ocular sarcoidosis was more prevalent in women. Further research is warranted to explore the implications of these findings for treatment strategies and prognostic assessments.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":" ","pages":"125-132"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Ocular Immunology and Inflammation
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