Pub Date : 2024-09-01Epub Date: 2023-05-19DOI: 10.1080/09273948.2023.2215322
Louis Debillon, Jennifer E Thorne, Elodie Bousquet, Pierre Duraffour, Souhila Kecili, Dominique Monnet, Antoine P Brézin
Purpose: To assess the manifestations of birdshot chorioretinitis (BSCR) in patients aged 80 and over.
Design: Among patients with BSCR followed in the CO-BIRD prospective cohort (ClinicalTrials.gov Identifier: NCT05153057), we analyzed the subgroup of patients aged 80 and over.
Methods: Patients were assessed in a standardized manner. Confluent atrophy was defined as hypoautofluorescent spots on fundus autofluorescence (FAF).
Results: We included 39 (8.8%) of the 442 enrolled CO-BIRD patients. The mean age was 83.8 ± 3.7 years. The mean logMAR BCVA was 0.52 ± 0.76, with 30 patients (76.9%) having 20/40 or better in at least one eye. Thirty-five (89.7%) patients were receiving no treatment. Confluent atrophy in the posterior pole, disrupted retrofoveal ellipsoid zone and choroidal neovascularization were associated with logMAR BCVA >0.3 (p < .0001).
Conclusion: In patients aged 80 and over we observed a striking heterogeneity of outcomes, but most retained a BCVA that allowed them to drive.
{"title":"Birdshot Chorioretinitis in Patients Aged 80 and Older.","authors":"Louis Debillon, Jennifer E Thorne, Elodie Bousquet, Pierre Duraffour, Souhila Kecili, Dominique Monnet, Antoine P Brézin","doi":"10.1080/09273948.2023.2215322","DOIUrl":"10.1080/09273948.2023.2215322","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the manifestations of birdshot chorioretinitis (BSCR) in patients aged 80 and over.</p><p><strong>Design: </strong>Among patients with BSCR followed in the CO-BIRD prospective cohort (ClinicalTrials.gov Identifier: NCT05153057), we analyzed the subgroup of patients aged 80 and over.</p><p><strong>Methods: </strong>Patients were assessed in a standardized manner. Confluent atrophy was defined as hypoautofluorescent spots on fundus autofluorescence (FAF).</p><p><strong>Results: </strong>We included 39 (8.8%) of the 442 enrolled CO-BIRD patients. The mean age was 83.8 ± 3.7 years. The mean logMAR BCVA was 0.52 ± 0.76, with 30 patients (76.9%) having 20/40 or better in at least one eye. Thirty-five (89.7%) patients were receiving no treatment. Confluent atrophy in the posterior pole, disrupted retrofoveal ellipsoid zone and choroidal neovascularization were associated with logMAR BCVA >0.3 (<i>p</i> < .0001).</p><p><strong>Conclusion: </strong>In patients aged 80 and over we observed a striking heterogeneity of outcomes, but most retained a BCVA that allowed them to drive.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9494426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2023-07-11DOI: 10.1080/09273948.2023.2230261
Sahar H AlAli, Piergiorgio Neri, Francesco Pichi
Despite having 20/20 vision, a 17-year-old Emirati female presented with central visual changes in her left eye. These changes were attributed to a dull foveal reflex with pigmentary alterations. Retinal pigment epithelium (RPE) mottling at the macula level, attenuating the ellipsoid zone, and a hyper-reflective line connecting the RPE to the outer nuclear layer was observed through spectral domain optical coherence tomography (SD-OCT) of the left eye. In the presence of negative results from laboratory evaluations, the patient was started on oral prednisolone. The medication induced an increased reflectivity of the inner layers on SD-OCT, which turned into a full-thickness macular retinitis with vitreous inflammation, causing a visual decrease to 20/80. A vitreous tap confirmed a positive result for HSV-1, and the patient was prescribed oral valacyclovir 3 g. This treatment led to a resolution of the retinitis and a restoration of the patient's vision to 20/25.
{"title":"Focal Posterior Herpetic Retinitis.","authors":"Sahar H AlAli, Piergiorgio Neri, Francesco Pichi","doi":"10.1080/09273948.2023.2230261","DOIUrl":"10.1080/09273948.2023.2230261","url":null,"abstract":"<p><p>Despite having 20/20 vision, a 17-year-old Emirati female presented with central visual changes in her left eye. These changes were attributed to a dull foveal reflex with pigmentary alterations. Retinal pigment epithelium (RPE) mottling at the macula level, attenuating the ellipsoid zone, and a hyper-reflective line connecting the RPE to the outer nuclear layer was observed through spectral domain optical coherence tomography (SD-OCT) of the left eye. In the presence of negative results from laboratory evaluations, the patient was started on oral prednisolone. The medication induced an increased reflectivity of the inner layers on SD-OCT, which turned into a full-thickness macular retinitis with vitreous inflammation, causing a visual decrease to 20/80. A vitreous tap confirmed a positive result for HSV-1, and the patient was prescribed oral valacyclovir 3 g. This treatment led to a resolution of the retinitis and a restoration of the patient's vision to 20/25.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10128989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2023-06-22DOI: 10.1080/09273948.2023.2219312
Nurettin Bayram, Cemal Ozsaygılı, Medine Gundogan, Sefa Unal, Fatma Bagci, Emine Pangal, I Sa Yuvacı
Purpose: This study aimed to investigate the effects of severe COVID-19 infection on the corneal endothelium via in vivo specular microscopy.
Methods: This was an observational, prospective, and controlled study including 56 eyes of 56 severe COVID-19 patients, compared to after-recovery and 56 eyes of 56 age- and gender-matched healthy controls.
Results: Endothelial cell density was lower in the active disease period compared to healthy controls (p = .001) and decreased even more after recovery (p < .0001). After recovery, the average cell area and coefficient of variation were higher compared to the active disease period (p < .0001 and p = .008, respectively) and the healthy controls (for both, p < .0001), whereas hexagonality was lower (p < .0001). Central corneal thickness increased in the active disease period compared to after recovery (p < .0001) and healthy controls (p = .002).
Conclusions: These results may be due to direct host-virus interaction or linked to immune dysregulation, subclinical corneal endotheliitis, or still yet a viral-mediated inflammation.
目的:本研究旨在通过体内镜下显微镜观察严重 COVID-19 感染对角膜内皮的影响:这是一项观察性、前瞻性和对照研究,研究对象包括56名重症COVID-19患者的56只眼睛,与康复后的56只眼睛以及56名年龄和性别匹配的健康对照者的56只眼睛进行比较:结果:与健康对照组相比,内皮细胞密度在疾病活动期较低(p = .001),在康复后(p p p = .008,分别)和健康对照组(两者均为p p p = .002)下降得更多:这些结果可能是由于宿主与病毒之间的直接相互作用,也可能与免疫调节失调、亚临床角膜内皮炎或病毒介导的炎症有关。
{"title":"The Impact of Severe COVID-19 on Corneal Endothelial Cells-Analysis of the In Vivo Noncontact Specular Microscopy.","authors":"Nurettin Bayram, Cemal Ozsaygılı, Medine Gundogan, Sefa Unal, Fatma Bagci, Emine Pangal, I Sa Yuvacı","doi":"10.1080/09273948.2023.2219312","DOIUrl":"10.1080/09273948.2023.2219312","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the effects of severe COVID-19 infection on the corneal endothelium via in vivo specular microscopy.</p><p><strong>Methods: </strong>This was an observational, prospective, and controlled study including 56 eyes of 56 severe COVID-19 patients, compared to after-recovery and 56 eyes of 56 age- and gender-matched healthy controls.</p><p><strong>Results: </strong>Endothelial cell density was lower in the active disease period compared to healthy controls (<i>p</i> = .001) and decreased even more after recovery (<i>p</i> < .0001). After recovery, the average cell area and coefficient of variation were higher compared to the active disease period (<i>p</i> < .0001 and <i>p</i> = .008, respectively) and the healthy controls (for both, <i>p</i> < .0001), whereas hexagonality was lower (<i>p</i> < .0001). Central corneal thickness increased in the active disease period compared to after recovery (<i>p</i> < .0001) and healthy controls (<i>p</i> = .002).</p><p><strong>Conclusions: </strong>These results may be due to direct host-virus interaction or linked to immune dysregulation, subclinical corneal endotheliitis, or still yet a viral-mediated inflammation.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9668243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This review summarizes the impact of systemic and ocular inflammatory disorders on diabetes mellitus (DM) and diabetic retinopathy (DR). Local inflammation is a key pathology in diabetic retinopathy (DR) and is also an evolving target for clinical therapy. The legacy effects of local inflammation at the intracellular level make DR a persistent self-driven vicious process. Ocular inflammation is accompanied as well as incited by systemic inflammation due to diabetes mellitus (DM) itself. Over the years, a multitude of studies have evaluated the impact of systemic inflammatory disorders (SIDs, like rheumatoid arthritis, lupus, psoriasis, etc.) and anti-inflammatory drugs prescribed for managing them on manifestations of DM. Recent studies have indicated increased insulin resistance to be a result of chronic inflammation, and the anti-inflammatory drugs to have a protective effect towards DM. Very few studies have evaluated the impact of SIDs on DR. Furthermore, the evidence from these studies is conflicting, and while local anti-inflammatory therapy has shown a lot of clinical potential for use in DR, the results of systemic anti-inflammatory therapies have been inconsistent. The impact of local ocular inflammation due to uveitis on DR is a crucial aspect that has not been evaluated well at present. Initial pre-clinical studies and small-sized clinical reports have shown a strong and positive relationship between the presence of uveitis and the severity of DR as well as its progression, while larger cross-sectional patient surveys have refuted the same. The long term impact of ocular inflammation due to uveitis on DR needs to be studied while adjusting for confounders.
本综述总结了全身性和眼部炎症性疾病对糖尿病(DM)和糖尿病视网膜病变(DR)的影响。局部炎症是糖尿病视网膜病变(DR)的关键病理,也是不断发展的临床治疗靶点。局部炎症在细胞内的遗留效应使糖尿病视网膜病变成为一个持续的自我驱动的恶性过程。眼部炎症既伴随着糖尿病(DM)本身引起的全身炎症,也是全身炎症的诱因。多年来,大量研究评估了全身性炎症性疾病(SIDs,如类风湿性关节炎、红斑狼疮、银屑病等)和治疗这些疾病的抗炎药物对糖尿病表现的影响。最近的研究表明,胰岛素抵抗的增加是慢性炎症的结果,而抗炎药物对糖尿病有保护作用。很少有研究评估了 SID 对糖尿病的影响。此外,这些研究的证据相互矛盾,虽然局部抗炎疗法在用于 DR 方面显示出很大的临床潜力,但全身抗炎疗法的结果却不一致。葡萄膜炎引起的局部眼部炎症对 DR 的影响是一个至关重要的方面,但目前尚未得到很好的评估。最初的临床前研究和小规模临床报告显示,葡萄膜炎的存在与 DR 的严重程度及其进展之间存在密切的正相关关系,而更大规模的横断面患者调查则反驳了这一观点。葡萄膜炎导致的眼部炎症对 DR 的长期影响需要在调整混杂因素后进行研究。
{"title":"Diabetes, Diabetic Retinopathy, and Inflammatory Disorders.","authors":"Abhishek Sheemar, Pallavi Goel, Pratima Singh Thakur, Brijesh Takkar, Inderjeet Kaur, Padmaja K Rani, Mudit Tyagi, Soumyava Basu, Pradeep Venkatesh","doi":"10.1080/09273948.2023.2203742","DOIUrl":"10.1080/09273948.2023.2203742","url":null,"abstract":"<p><p>This review summarizes the impact of systemic and ocular inflammatory disorders on diabetes mellitus (DM) and diabetic retinopathy (DR). Local inflammation is a key pathology in diabetic retinopathy (DR) and is also an evolving target for clinical therapy. The legacy effects of local inflammation at the intracellular level make DR a persistent self-driven vicious process. Ocular inflammation is accompanied as well as incited by systemic inflammation due to diabetes mellitus (DM) itself. Over the years, a multitude of studies have evaluated the impact of systemic inflammatory disorders (SIDs, like rheumatoid arthritis, lupus, psoriasis, etc.) and anti-inflammatory drugs prescribed for managing them on manifestations of DM. Recent studies have indicated increased insulin resistance to be a result of chronic inflammation, and the anti-inflammatory drugs to have a protective effect towards DM. Very few studies have evaluated the impact of SIDs on DR. Furthermore, the evidence from these studies is conflicting, and while local anti-inflammatory therapy has shown a lot of clinical potential for use in DR, the results of systemic anti-inflammatory therapies have been inconsistent. The impact of local ocular inflammation due to uveitis on DR is a crucial aspect that has not been evaluated well at present. Initial pre-clinical studies and small-sized clinical reports have shown a strong and positive relationship between the presence of uveitis and the severity of DR as well as its progression, while larger cross-sectional patient surveys have refuted the same. The long term impact of ocular inflammation due to uveitis on DR needs to be studied while adjusting for confounders.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9487803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2023-09-15DOI: 10.1080/09273948.2023.2247077
Zheting Zhang, Konstadina Griva, William Rojas-Carabali, Gazal Patnaik, Renee Liu, Lucia Sobrin, John H Kempen, Robert P Finger, Vishali Gupta, Bryan Ang, Rupesh Agrawal
Purpose: As a potentially sight-threatening disease with ocular, systemic, and treatment-related complications, uveitis diminishes quality of life (QOL) and affects psychosocial well-being. This review summarizes the existing tools for evaluating psychosocial well-being and/or QOL in patients with uveitis, explores the biological and non-biological factors affecting psychosocial well-being and/or QOL, and proposes future directions for incorporating these tools into clinical practice.
Methods: A systematic search of the MEDLINE, Embase, and Cochrane databases from inception to June 8, 2022 was conducted, screening for articles focused on psychosocial well-being and/or QOL in patients with uveitis. Both quantitative and qualitative analyses were performed.
Results: In uveitis research, the most frequently studied patient-reported outcome measures were vision-related QOL (e.g. Visual Function Questionnaire [VFQ-25]) and health-related QOL (e.g. Short Form Survey [SF-36]), followed by mental health indicators including depression and anxiety. Instruments have also been developed specific to the pediatric population (e.g. Effects of Youngsters' Eyesight on Quality of Life [EYE-Q]). Generally, studies report worse psychosocial outcomes and QOL in patients with uveitis compared to the general population. Contributory factors include both clinical (e.g. visual impairment, ocular comorbidities) and patient-related (e.g. older age, female sex) factors.
Conclusion: Given the heterogeneity of instruments used, it is worth considering standardization across large uveitis studies and trials. Beyond research, given the biopsychosocial effects on patients with uveitis, there are benefits to incorporating QOL and psychosocial assessments into clinical practice. Simplification of questionnaires into abridged forms, focusing on the most clinically relevant aspects of patient care, may be considered.
目的:葡萄膜炎是一种可能危及视力的疾病,具有眼部、全身和治疗相关并发症,会降低患者的生活质量(QOL)并影响社会心理健康。本综述总结了评估葡萄膜炎患者社会心理健康和/或 QOL 的现有工具,探讨了影响社会心理健康和/或 QOL 的生物和非生物因素,并提出了将这些工具纳入临床实践的未来方向:方法:对MEDLINE、Embase和Cochrane数据库从开始到2022年6月8日的内容进行了系统检索,筛选出关注葡萄膜炎患者社会心理健康和/或QOL的文章。研究同时进行了定量和定性分析:在葡萄膜炎研究中,最常研究的患者报告结果指标是视力相关QOL(如视觉功能问卷[VFQ-25])和健康相关QOL(如简表调查[SF-36]),其次是心理健康指标,包括抑郁和焦虑。此外,还开发了专门针对儿科人群的工具(如《青少年视力对生活质量的影响》[EYE-Q])。一般来说,研究报告显示葡萄膜炎患者的心理社会结果和生活质量不如普通人群。促成因素包括临床因素(如视力损伤、眼部并发症)和患者相关因素(如年龄较大、女性):鉴于所用工具的异质性,值得考虑在大型葡萄膜炎研究和试验中实现标准化。除研究外,考虑到葡萄膜炎患者的生物心理社会影响,将 QOL 和心理社会评估纳入临床实践也有好处。可以考虑将问卷简化为简表,重点关注与临床最相关的患者护理方面。
{"title":"Psychosocial Well-Being and Quality of Life in Uveitis: A Review.","authors":"Zheting Zhang, Konstadina Griva, William Rojas-Carabali, Gazal Patnaik, Renee Liu, Lucia Sobrin, John H Kempen, Robert P Finger, Vishali Gupta, Bryan Ang, Rupesh Agrawal","doi":"10.1080/09273948.2023.2247077","DOIUrl":"10.1080/09273948.2023.2247077","url":null,"abstract":"<p><strong>Purpose: </strong>As a potentially sight-threatening disease with ocular, systemic, and treatment-related complications, uveitis diminishes quality of life (QOL) and affects psychosocial well-being. This review summarizes the existing tools for evaluating psychosocial well-being and/or QOL in patients with uveitis, explores the biological and non-biological factors affecting psychosocial well-being and/or QOL, and proposes future directions for incorporating these tools into clinical practice.</p><p><strong>Methods: </strong>A systematic search of the MEDLINE, Embase, and Cochrane databases from inception to June 8, 2022 was conducted, screening for articles focused on psychosocial well-being and/or QOL in patients with uveitis. Both quantitative and qualitative analyses were performed.</p><p><strong>Results: </strong>In uveitis research, the most frequently studied patient-reported outcome measures were vision-related QOL (e.g. Visual Function Questionnaire [VFQ-25]) and health-related QOL (e.g. Short Form Survey [SF-36]), followed by mental health indicators including depression and anxiety. Instruments have also been developed specific to the pediatric population (e.g. Effects of Youngsters' Eyesight on Quality of Life [EYE-Q]). Generally, studies report worse psychosocial outcomes and QOL in patients with uveitis compared to the general population. Contributory factors include both clinical (e.g. visual impairment, ocular comorbidities) and patient-related (e.g. older age, female sex) factors.</p><p><strong>Conclusion: </strong>Given the heterogeneity of instruments used, it is worth considering standardization across large uveitis studies and trials. Beyond research, given the biopsychosocial effects on patients with uveitis, there are benefits to incorporating QOL and psychosocial assessments into clinical practice. Simplification of questionnaires into abridged forms, focusing on the most clinically relevant aspects of patient care, may be considered.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10261086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2023-06-14DOI: 10.1080/09273948.2023.2219733
Ibadulla Mirzayev, Ahmet Kaan Gündüz, Aylin Okçu Heper
Purpose: To report a rare case of atopic keratoconjunctivitis (AKC) presenting with bilateral corneal panni associated with limbal inclusion cysts in the left eye.
Materials & methods: Retrospective case report.
Results: A 19-year-old female with AKC presented with bilateral corneal panni and limbal inclusion cysts in the left eye. Anterior segment swept-source optical coherence tomography showed bilateral hyperreflective epicorneal membrane and a lobulated cystic lesion in the left eye. Ultrasound biomicroscopy demonstrated a dense membrane overriding the cornea in both eyes and hyporeflective spaces separated by medium reflective septa in the cyst. The patient underwent excision of the limbal inclusion cyst and pannus in the left eye. Histopathological examination revealed subepithelial cystic lesion surrounded by non-keratinizing epithelium; areas of acanthosis, hyperkeratosis, parakeratosis, and hyperplasia in the epithelium of the pannus; as well as inflammation, fibrosis, and increase in vascularization in the stroma.
Conclusion: To our knowledge, this is the first case of corneal pannus associated with limbal inclusion cysts in AKC. Surgical excision was done to establish the diagnosis as well as to improve vision in our case.
{"title":"Bilateral Corneal Panni Associated with Limbal Inclusion Cysts in the Left Eye in a Patient with Atopic Keratoconjunctivitis.","authors":"Ibadulla Mirzayev, Ahmet Kaan Gündüz, Aylin Okçu Heper","doi":"10.1080/09273948.2023.2219733","DOIUrl":"10.1080/09273948.2023.2219733","url":null,"abstract":"<p><strong>Purpose: </strong>To report a rare case of atopic keratoconjunctivitis (AKC) presenting with bilateral corneal panni associated with limbal inclusion cysts in the left eye.</p><p><strong>Materials & methods: </strong>Retrospective case report.</p><p><strong>Results: </strong>A 19-year-old female with AKC presented with bilateral corneal panni and limbal inclusion cysts in the left eye. Anterior segment swept-source optical coherence tomography showed bilateral hyperreflective epicorneal membrane and a lobulated cystic lesion in the left eye. Ultrasound biomicroscopy demonstrated a dense membrane overriding the cornea in both eyes and hyporeflective spaces separated by medium reflective septa in the cyst. The patient underwent excision of the limbal inclusion cyst and pannus in the left eye. Histopathological examination revealed subepithelial cystic lesion surrounded by non-keratinizing epithelium; areas of acanthosis, hyperkeratosis, parakeratosis, and hyperplasia in the epithelium of the pannus; as well as inflammation, fibrosis, and increase in vascularization in the stroma.</p><p><strong>Conclusion: </strong>To our knowledge, this is the first case of corneal pannus associated with limbal inclusion cysts in AKC. Surgical excision was done to establish the diagnosis as well as to improve vision in our case.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9636152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2023-07-14DOI: 10.1080/09273948.2023.2226206
Lingling Huang, Christina Flaxel, Eric Suhler, Phoebe Lin
Chronic central serous chorioretinopathy (CSCR) is a sight threatening disease that can lead to legal blindness. Verteporfin photodynamic therapy is the main treatment for chronic CSCR, however, there has been a critical worldwide shortage of verteporfin. Other medical treatments have been attempted with variable efficacy. Interferons have shown efficacy in treating uveitis and associated macular edema. We report 2 cases of treatment refractory chronic CSCR successfully treated with subcutaneous injection of interferon alpha with significant anatomical and functional improvement. To our knowledge, this is the first report observing the therapeutic potential of systemic interferon alpha in the treatment of chronic CSCR. A large randomized controlled clinical trial would help to better evaluate the safety and efficacy of systemic PEG-IFNα2a in treating chronic CSCR, and further define the optimal dose, treatment interval and duration.
{"title":"Two Cases of Chronic Central Serous Chorioretinopathy Successfully Treated with Systemic Interferon Alpha.","authors":"Lingling Huang, Christina Flaxel, Eric Suhler, Phoebe Lin","doi":"10.1080/09273948.2023.2226206","DOIUrl":"10.1080/09273948.2023.2226206","url":null,"abstract":"<p><p>Chronic central serous chorioretinopathy (CSCR) is a sight threatening disease that can lead to legal blindness. Verteporfin photodynamic therapy is the main treatment for chronic CSCR, however, there has been a critical worldwide shortage of verteporfin. Other medical treatments have been attempted with variable efficacy. Interferons have shown efficacy in treating uveitis and associated macular edema. We report 2 cases of treatment refractory chronic CSCR successfully treated with subcutaneous injection of interferon alpha with significant anatomical and functional improvement. To our knowledge, this is the first report observing the therapeutic potential of systemic interferon alpha in the treatment of chronic CSCR. A large randomized controlled clinical trial would help to better evaluate the safety and efficacy of systemic PEG-IFNα2a in treating chronic CSCR, and further define the optimal dose, treatment interval and duration.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10787811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9833862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2023-05-10DOI: 10.1080/09273948.2023.2205525
Ruifen Wei, Qianqian Chen, Qinxiang Zheng, Peter S Reinach, Xiying Tan, Chengjie Pan, Wei Xu, Louis Tong, Wei Chen
Purpose: To explore whether circadian clock genes contribute to elicit inflammation in experimental dry eye (EDE).
Methods: RNA sequencing analyzed mRNA expression patterns in EDE model. RT-qPCR and/or Western blot determined the expression of inflammatory factors and circadian genes during EDE. MethylTarget™ assays determined the promoter methylation levels of Per genes in vivo. Per2 or Per3 knockdown assessed their effects on inflammatory factors in vitro.
Results: We utilized an intelligently controlled environmental system (ICES) to establish a mouse EDE model. The significant upregulated genes were enriched for circadian rhythms. Therein lied oscillatory and time-dependent upregulation of PER2 and PER3, as well as their promoter hypomethylation during EDE. Silencing PER2 or PER3 significantly decreased inflammatory factor expression and also reversed such increased inflammatory response in azacitidine (AZA) treatment in vitro model.
Conclusions: Our findings suggest that DNA methylation mediated the upregulation of PER2 and PER3, leading to inflammatory response in EDE.
目的:探讨昼夜节律时钟基因是否有助于引发实验性干眼症(EDE)的炎症:方法:RNA测序分析EDE模型中mRNA的表达模式。RT-qPCR和/或Western blot检测EDE过程中炎症因子和昼夜节律基因的表达。MethylTarget™ 检测确定了体内 Per 基因启动子甲基化水平。Per2或Per3基因敲除评估了它们对体外炎症因子的影响:我们利用智能控制环境系统(ICES)建立了小鼠 EDE 模型。显著上调的基因富含昼夜节律。在 EDE 期间,PER2 和 PER3 存在振荡和时间依赖性上调及其启动子低甲基化。在阿扎胞苷(AZA)治疗的体外模型中,沉默PER2或PER3可显著降低炎症因子的表达,并逆转这种炎症反应的增加:我们的研究结果表明,DNA甲基化介导了PER2和PER3的上调,导致了EDE中的炎症反应。
{"title":"Epigenetic Activation of Circadian Clock Genes Elicits Inflammation in Experimental Murine Dry Eye.","authors":"Ruifen Wei, Qianqian Chen, Qinxiang Zheng, Peter S Reinach, Xiying Tan, Chengjie Pan, Wei Xu, Louis Tong, Wei Chen","doi":"10.1080/09273948.2023.2205525","DOIUrl":"10.1080/09273948.2023.2205525","url":null,"abstract":"<p><strong>Purpose: </strong>To explore whether circadian clock genes contribute to elicit inflammation in experimental dry eye (EDE).</p><p><strong>Methods: </strong>RNA sequencing analyzed mRNA expression patterns in EDE model. RT-qPCR and/or Western blot determined the expression of inflammatory factors and circadian genes during EDE. MethylTarget™ assays determined the promoter methylation levels of Per genes in vivo. Per2 or Per3 knockdown assessed their effects on inflammatory factors in vitro.</p><p><strong>Results: </strong>We utilized an intelligently controlled environmental system (ICES) to establish a mouse EDE model. The significant upregulated genes were enriched for circadian rhythms. Therein lied oscillatory and time-dependent upregulation of PER2 and PER3, as well as their promoter hypomethylation during EDE. Silencing PER2 or PER3 significantly decreased inflammatory factor expression and also reversed such increased inflammatory response in azacitidine (AZA) treatment in vitro model.</p><p><strong>Conclusions: </strong>Our findings suggest that DNA methylation mediated the upregulation of PER2 and PER3, leading to inflammatory response in EDE.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9436428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2023-08-14DOI: 10.1080/09273948.2023.2243497
Yosef Milstein, Elianora Haiimov, Mordechai Slae, Zev Davidovics, Peri Millman, Liron Birimberg-Schwartz, Ariel Benson, Michael Wilschanski, Radgonde Amer
Purpose: To examine whether patients with non-infectious uveitis (NIU) are at increased risk for celiac disease (CeD).
Methods: Celiac antibody testing was completed in 112 patients. The control group included patients who had undergone upper endoscopy for suspicion of CeD.
Results: 2/112 (1.79%) of patients with NIU had positive anti-tTG serology and CeD was confirmed in both patients. When compared to the expected risk of CeD in the general Israeli population of 0.31%, this corresponded to an odds ratio of 5.77 (95% CI 1.4118 to 23.4737, P = 0.049). Three additional patients had positive serology for CeD but the diagnosis was not confirmed.
Conclusions: An increased risk of CeD was detected in patients with NIU. We therefore recommend screening for CeD in NIU patients. Larger prospective studies are required to further validate these results.
{"title":"Increased Risk of Celiac Disease in Patients with Uveitis.","authors":"Yosef Milstein, Elianora Haiimov, Mordechai Slae, Zev Davidovics, Peri Millman, Liron Birimberg-Schwartz, Ariel Benson, Michael Wilschanski, Radgonde Amer","doi":"10.1080/09273948.2023.2243497","DOIUrl":"10.1080/09273948.2023.2243497","url":null,"abstract":"<p><strong>Purpose: </strong>To examine whether patients with non-infectious uveitis (NIU) are at increased risk for celiac disease (CeD).</p><p><strong>Methods: </strong>Celiac antibody testing was completed in 112 patients. The control group included patients who had undergone upper endoscopy for suspicion of CeD.</p><p><strong>Results: </strong>2/112 (1.79%) of patients with NIU had positive anti-tTG serology and CeD was confirmed in both patients. When compared to the expected risk of CeD in the general Israeli population of 0.31%, this corresponded to an odds ratio of 5.77 (95% CI 1.4118 to 23.4737, <i>P</i> = 0.049). Three additional patients had positive serology for CeD but the diagnosis was not confirmed.</p><p><strong>Conclusions: </strong>An increased risk of CeD was detected in patients with NIU. We therefore recommend screening for CeD in NIU patients. Larger prospective studies are required to further validate these results.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10002547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2023-08-16DOI: 10.1080/09273948.2023.2246549
Ivo De Clerck
Purpose: To describe the clinical and epidemiological characteristics of the first epidemic of Rift Valley Fever retinitis in Rwanda and to report novel imaging findings and a possible role for corticosteroids.
Methods: Retrospective analysis of all patients who presented with presumed Rift Valley Fever retinitis at the Rwanda Charity Eye Hospital over a period of 4 months in 2022. Multimodal images are reviewed including optical coherence tomography, fluorescein angiography, color, infrared, red-free, and autofluorescence photography.
Results: The newly identified arciform hyporeflective pattern on infrared imaging was present in 100% of patients. Out of 9 patients treated with oral corticosteroids, 7 (78%) experienced a visual acuity increase of at least 0.2 during follow-up, in comparison to only 4 (28%) out of 14 of untreated patients. Out of four patients treated with a subtenon corticosteroid injection, only one (25%) reached this threshold. Post-hoc pairwise comparison with Bonferroni correction revealed a significant difference in average visual acuity improvement (p = 0.034) between patients receiving oral corticosteroids (0.35 ± 0.07) versus no treatment (0.11 ± 0.04).
Conclusion: The identified arciform hyporeflective pattern on infrared imaging appears to be characteristic of Rift Valley Fever retinitis and should be known to clinicians working in endemic regions. Compared to a historical cohort and to untreated patients in this non-randomized study, there appears to be a benefit of treatment with oral corticosteroids.
{"title":"Outbreak of Rift Valley Fever Retinitis in Rwanda: Novel Imaging Findings and Response to Treatment with Corticosteroids.","authors":"Ivo De Clerck","doi":"10.1080/09273948.2023.2246549","DOIUrl":"10.1080/09273948.2023.2246549","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the clinical and epidemiological characteristics of the first epidemic of Rift Valley Fever retinitis in Rwanda and to report novel imaging findings and a possible role for corticosteroids.</p><p><strong>Methods: </strong>Retrospective analysis of all patients who presented with presumed Rift Valley Fever retinitis at the Rwanda Charity Eye Hospital over a period of 4 months in 2022. Multimodal images are reviewed including optical coherence tomography, fluorescein angiography, color, infrared, red-free, and autofluorescence photography.</p><p><strong>Results: </strong>The newly identified arciform hyporeflective pattern on infrared imaging was present in 100% of patients. Out of 9 patients treated with oral corticosteroids, 7 (78%) experienced a visual acuity increase of at least 0.2 during follow-up, in comparison to only 4 (28%) out of 14 of untreated patients. Out of four patients treated with a subtenon corticosteroid injection, only one (25%) reached this threshold. Post-hoc pairwise comparison with Bonferroni correction revealed a significant difference in average visual acuity improvement (<i>p</i> = 0.034) between patients receiving oral corticosteroids (0.35 ± 0.07) versus no treatment (0.11 ± 0.04).</p><p><strong>Conclusion: </strong>The identified arciform hyporeflective pattern on infrared imaging appears to be characteristic of Rift Valley Fever retinitis and should be known to clinicians working in endemic regions. Compared to a historical cohort and to untreated patients in this non-randomized study, there appears to be a benefit of treatment with oral corticosteroids.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10013256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}