Ophthalmology. Glaucoma最新文献

英文中文

Rapid Reversal of Optic Nerve Cupping in Steroid-Induced Glaucoma 类固醇性青光眼视神经拔罐快速逆转。

IF 2.8 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2025-07-01 DOI: 10.1016/j.ogla.2025.03.005

Manasi Tripathi MD, FRCS, Vinit Tanwar MD, Varun Gogia MD

引用次数: 0

Risk of Falls, Fear of Falling, and Rates of Visual Field Progression in Glaucoma in the African Descent and Glaucoma Evaluation Study 非洲裔青光眼患者跌倒风险、跌倒恐惧和视野进展率及青光眼评估研究

IF 2.8 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2025-07-01 DOI: 10.1016/j.ogla.2025.02.002

Alexander F. Dagi MPhil , C. Gustavo De Moraes MD, PhD , Christopher A. Girkin MD, MSPH , George A. Cioffi MD , Robert N. Weinreb MD , Linda M. Zangwill PhD , Jeffrey M. Liebmann MD

Purpose

To assess the relationships between rates of glaucomatous visual field (VF) progression, fear of falling (FoF), history of falls, and ancestry.

Design

Prospective, multicenter, longitudinal cohort.

Subjects

Patients followed in the multisite African Descent and Glaucoma Evaluation Study with primary open-angle glaucoma and who completed a validated fear of falling questionnaire along with a self-reported history of falls in the past year were enrolled.

Methods

Baseline VF severity and VF progression rates were assessed using 24-2 VF mean deviation (MD). We used univariable and multivariable models adjusting for confounders (age, sex, ancestry, and baseline MD) using clustered robust logistic regression and linear regression.

Main Outcome Measures

The primary outcome measure was the relationship between history of falls (yes vs. no) as a dependent variable and MD slopes (dB/year). The secondary outcome measure was the relationship between FoF scores (continuous) as a dependent variable and MD slopes (dB/year).

Results

There were 4453 patient encounters, including at least 5 VF tests per patient with a minimum of 2 years of follow-up in 277 eyes of 183 individuals. Faster MD slopes were significantly associated with a history of falls in both univariable (odds ratio [OR]: 2.68 per dB/year faster rates; 95% confidence interval [CI]: 1.35–5.33; P = 0.005) and multivariable models (OR: 2.55; 95% CI: 1.29–5.04; P = 0.007). Rapid progressors (MD slope less than −0.5 dB/year) were 2.45-fold more likely to have a positive history of falls (95% CI: 1.22–4.91, P = 0.012). Faster MD slopes were significantly associated with worse FoF in both univariable (β: 2.97 per dB/year faster rates; 95% CI: 0.41–5.54; P = 0.023) and multivariable (β: 2.27; 95% CI: 0.17–4.36; P = 0.034) models. Patients of African descent (AD) were as likely to have a history of falls and had similar FoF scores as those of European descent (ED) (all P > 0.40).

Conclusions

A faster rate of MD progression is associated with a greater fear of falling and history of falls among AD and ED treated glaucoma patients. Rapid progressors were almost threefold more likely to have a history of falls. The 2 ancestry groups also experienced similar rates of falls and fear of fall scores.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

目的：评估青光眼视野（VF）进展率、跌倒恐惧、跌倒史和血统之间的关系。设计：前瞻性、多中心、纵向队列研究。受试者：在多地点非洲裔和青光眼评估研究（ADAGES）中随访的原发性开角型青光眼患者，完成了一份经过验证的跌倒恐惧问卷，并报告了过去一年的跌倒史。方法：采用24-2 VF平均偏差（MD）评估基线VF严重程度和VF进展率。我们使用单变量和多变量模型调整混杂因素（年龄、性别、血统和基线MD），采用聚类稳健逻辑回归和线性回归。主要结局指标：主要结局指标是跌倒史（是否跌倒）作为因变量与MD斜率（dB/年）之间的关系。次要结果测量是跌倒恐惧（FoF）得分（连续）作为因变量与MD斜率（dB/年）之间的关系。结果：共有4453例患者，包括每位患者至少5次VF测试，对183人的277只眼睛进行了至少2年的随访。在两个单变量中，更快的MD斜率与跌倒史显著相关(OR: 2.68 / dB/年更快的速率；95%CI: 1.35 ~ 5.33；P=0.005)和多变量模型(OR: 2.55；95%CI: 1.29 ~ 5.04；P = 0.007)。快速进展（MD斜率0.40）。结论：在AD和ED治疗的青光眼患者中，更快的MD进展速度与更大的跌倒恐惧和跌倒史相关。快速进展者有跌倒史的可能性几乎高出3倍。这两个祖先群体也经历了相似的跌倒率和对跌倒分数的恐惧。

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引用次数: 0

An Outflow of Trials, Tribulations, and Perseverance 考验、磨难和毅力的流露。

IF 2.8 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2025-07-01 DOI: 10.1016/j.ogla.2025.05.002

Ronald L. Fellman MD, Davinder S. Grover MD, MPH, Ruikang K. Wang PhD

引用次数: 0

Milky Aqueous Humor 乳状幽默。

IF 2.8 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2025-07-01 DOI: 10.1016/j.ogla.2025.04.007

Tarannum Mansoori MS , Mantravadi Lakshmi Karthika MS

引用次数: 0

Microspherophakia: Kugel Fountain Presentation 微球：库格尔喷泉展示。

IF 2.8 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2025-07-01 DOI: 10.1016/j.ogla.2025.03.004

Devendra Maheshwari MS, Shivam Gupta MBBS, MS, Madhavi Pillai MBBS, MS

引用次数: 0

Comparison between the Fast Strategies of a Virtual Reality Perimetry and the Humphrey Field Analyzer in Patients with Glaucoma 青光眼患者虚拟现实视距测量与Humphrey视场分析仪快速策略的比较。

IF 2.8 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2025-05-01 DOI: 10.1016/j.ogla.2024.12.004

Fernanda Nicolela Susanna MD , Carolina Nicolela Susanna MD , Pedro Gabriel Salomão Libânio MD , Fernanda Tiemi Nishikawa MD , Renato Antunes Schiave Germano MD, PhD , Remo Susanna Junior MD, PhD

Purpose

This study compared the agreement between the Humphrey Field Analyzer (HFA) SITA Fast strategy and a novel virtual reality head-mounted visual perimetry device (VisuALL) in patients with glaucoma.

Design

This is prospective observational study.

Participants

This study was conducted on 62 eyes of 39 glaucoma subjects.

Methods

All participants had visual field (VF) testing with the VisuALL AVAFAST strategy and the HFA (24-2, Swedish Interactive Threshold Algorithm FAST). The mean sensitivity of the whole VF and each quadrant was compared between both machines. Additionally, the pattern deviation plot was analyzed to compare the agreement of both devices to detect localized VF defects.

Main Outcome Measures

Correlation and agreement between the mean sensitivity of the fast strategies from VisuALL and HFA.

Results

The global mean sensitivity of the VisuALL and the HFA correlated significantly (r = 0.60; P < 0.001) and was in agreement (r = 0.73; P < 0.001). The detection of VF defects in all quadrants was also moderately correlated and in agreement. Participants overwhelmingly preferred the VisuALL over the conventional (80%).

Conclusions

Although the mean sensitivity and ability to detect localized VF defects of the VisuALL were correlated and in agreement with the HFA, this was only moderate. This indicates that the VisuALL AVAFast strategy must be used with caution.

Financial Disclosure(s)

The author(s) have no proprietary or commercial interest in any materials discussed in this article.

目的：本研究比较了Humphrey Field Analyzer (HFA) SITA Fast策略和一种新型虚拟现实头戴式视距离仪（VisuALL）在青光眼患者中的一致性。设计：本研究为前瞻性观察性研究。参与者：本研究对39例青光眼患者的62只眼进行了研究。方法：所有受试者采用VisuALL AVAFAST策略和HFA （24-2, Swedish Interactive Threshold Algorithm FAST）进行视野测试。比较两种机器的全视野和各象限平均灵敏度。此外，分析了模式偏差（PD）图，以比较两种设备检测局部VF缺陷的一致性。主要结果：VisuALL和HFA快速策略的平均敏感性之间的相关性和一致性。结果：VisuALL与HFA的整体平均灵敏度有显著相关性（r= 0.60, P < 0.001），两者一致（r= 0.73, P < 0.001）。在所有象限的视野缺陷的检测也适度相关和一致。参与者绝大多数更喜欢VisuALL而不是传统的SAP（80%）。结论：虽然VisuALL的平均灵敏度和检测局部视野缺陷的能力与HFA相关，但这只是适度的。这表明VisuALL AVAFast策略必须谨慎使用。

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引用次数: 0

Metabolic Dysfunction-associated Steatotic Liver Disease Increases the Risk of Primary Open-Angle Glaucoma 代谢功能障碍相关的脂肪变性肝病增加原发性开角型青光眼的风险。

IF 2.8 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2025-05-01 DOI: 10.1016/j.ogla.2024.12.007

Chao Chen BS , Jiao Qi MD , Keke Zhang MD , Jiaqi Meng MD , Yi Lu MD, PhD , Fei Wang MD, PhD , Xiangjia Zhu MD, PhD

Purpose

Liver disease is associated with a range of extrahepatic complications, which have recently been expanded to include ophthalmic conditions. However, evidence is lacking regarding its impact on primary open-angle glaucoma (POAG). This study aimed to investigate whether major liver diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD), alcoholic liver disease (ALD), viral hepatitis, and liver fibrosis and cirrhosis, were associated with POAG.

Design

A prospective study based on the UK Biobank cohort with a 2-sample Mendelian randomization (MR) analysis for inferring causality.

Participants

A total of 332 345 UK Biobank participants free of glaucoma recruited between 2006 and 2010.

Methods

The exposures of interest were severe liver diseases defined as hospital admission, including MASLD, ALD, viral hepatitis, and liver fibrosis and cirrhosis. The Cox proportional hazard models were used with each liver disease treated as a time-varying exposure. The MR analysis was further conducted based on the genome-wide association studies of a histologically characterized cohort for MASLD (n = 19 264) and the International Glaucoma Genetics Consortium cohort for POAG (n = 216 257).

Main Outcome Measures

The risk of POAG estimated by hazard ratio (HR) and 95% confidence interval (CI) in observational analysis and odds ratio (OR) and 95% CI in MR analysis.

Results

Severe MASLD was associated with a 45% increased risk of POAG (HR, 1.45; 95% CI, 1.12–1.87; P = 0.005), whereas no association was identified between ALD, viral hepatitis, or liver fibrosis and cirrhosis and incident POAG. Subgroup analysis showed that the risk of POAG in relation to MASLD was higher in individuals having more physical activity (HR, 1.53; 95% CI, 1.04–2.25 vs. HR, 1.39; 95% CI, 0.99–1.95, P for interaction = 0.033). Mendelian randomization analysis provided evidence that MASLD was causally associated with a greater risk of POAG (inverse-variance weighted model: OR, 1.035; 95% CI, 1.010–1.061; P = 0.005).

Conclusions

Severe MASLD was longitudinally associated with an increased risk of incident POAG, with MR analyses suggesting a potential causal link. These findings suggest that a POAG examination should be considered in the holistic management of MASLD and further underscore the impact of the liver on eye health.

Financial Disclosure(s)

The authors have no proprietary or commercial interest in any materials discussed in this article.

目的：肝脏疾病与一系列肝外并发症相关，最近已扩大到包括眼科疾病。然而，其对原发性开角型青光眼（POAG）的影响尚缺乏证据。本研究旨在探讨主要肝脏疾病，包括代谢功能障碍相关脂肪变性肝病（MASLD）、酒精性肝病（ALD）、病毒性肝炎、肝纤维化和肝硬化是否与POAG相关。设计：一项基于英国生物银行队列的前瞻性研究，采用双样本孟德尔随机化（MR）分析来推断因果关系。参与者：在2006年至2010年期间招募了332,345名无青光眼的英国生物银行参与者。方法：研究对象为入院的严重肝病，包括MASLD、ALD、病毒性肝炎、肝纤维化和肝硬化。Cox比例风险模型用于将每种肝病作为时变暴露治疗。mri分析进一步基于MASLD （n = 19,264）和POAG （n = 216,257）的组织学特征队列的全基因组关联研究。主要结局指标：观察分析以风险比（HR）和95%置信区间（CI）估计POAG的风险，MR分析以优势比（OR）和95% CI估计POAG的风险。结果：重度MASLD与POAG风险增加45%相关(HR 1.45；95% ci 1.12-1.87；P = 0.005)，而ALD （P = 0.953）、病毒性肝炎（P = 0.519）或肝纤维化和肝硬化（P = 0.794）与POAG的发生没有关联。亚组分析显示，体力活动较多的个体与MASLD相关的POAG风险较高(HR 1.53；95% CI 1.04-2.25, HR 1.39；95% CI 0.99-1.95，交互作用P = 0.033)。MR分析提供的证据表明，MASLD与POAG的高风险存在因果关系(反方差加权模型：OR 1.035；95% ci 1.010-1.061；P = 0.005)。结论：严重的MASLD与POAG发生风险增加纵向相关，MR分析表明存在潜在的因果关系。这些发现提示在MASLD的整体治疗中应考虑POAG检查，并进一步强调肝脏对眼睛健康的影响。

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引用次数: 0

Association of Blood Pressure and Retinal Nerve Fiber Layer Rates of Thinning in Patients with Moderate to Advanced Glaucoma 中晚期青光眼患者血压与视网膜神经纤维层变薄率的关系

IF 2.8 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2025-05-01 DOI: 10.1016/j.ogla.2024.12.009

Judy Figueroa BS , Erica Su PhD , Vahid Mohammadzadeh MD , Sajad Besharati MD , Massood Mohammadi MD , Maryam Ashrafkhorasani MD , Simon K. Law MD, PharmD , Anne L. Coleman MD, PhD , Joseph Caprioli MD , Robert E. Weiss PhD , Kouros Nouri-Mahdavi MD, MS

Purpose

To investigate the influence of baseline blood pressure (BP) on retinal nerve fiber layer (RNFL) rates of change (RoCs) in glaucoma patients with central damage or moderate to severe disease.

Design

Prospective cohort study.

Participants

One hundred ten eyes with ≥ 4 RNFL OCT scans and ≥ 2 years of follow-up.

Methods

Global RNFL RoCs were modeled with a Bayesian hierarchical model with subject- and sector-level random effects. Influence of baseline systolic and diastolic BP measures and their interactions with intraocular pressure (IOP) on global RNFL RoCs was investigated in prognostic models adjusting for relevant baseline demographic and clinical measures.

Main Outcome Measures

Magnitude and direction of coefficients for BP, IOP, and their interaction for prediction of global RNFL RoCs. One-sided Bayesian P values denote posterior probability that a regression coefficient is greater than or less than zero, with P < 0.025 or P > 0.975 defining significance.

Results

Average (standard deviation) 24-2 visual field mean deviation (MD) at baseline, follow-up time, and number of OCT scans were −8.8 (6.0) dB, 4.3 (0.5) years, and 8.3 (1.4), respectively. In multivariable analyses, female sex, Hispanic ethnicity (vs. White ethnicity), better baseline 24-2 MD, higher contrast sensitivity at 12 cycles per degree, presence of diabetes, and thicker central cornea predicted faster RNFL thinning. Adjusted for covariates, lower diastolic BP combined with higher IOP predicted faster RNFL RoCs. Parallel multivariable models incorporating systolic BP showed similar effects. Among various BP/IOP combinations, eyes with IOP at the 90th percentile and diastolic (systolic) BP at 10th percentile demonstrated the fastest RNFL thinning rates (−0.554 and −0.539 μm/year).

Conclusions

Low BP and higher IOP at baseline predicted faster (worse) RNFL RoCs in glaucoma patients with central damage or moderate to advanced disease. Although there may be potential benefits to BP management in glaucoma patients, the therapeutic value of BP manipulation in glaucoma patients is yet to be established given the proven benefits of tight BP control in reducing cardiovascular morbidity and mortality.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

目的：探讨基线血压（BP）对中枢损害或中重度青光眼患者视网膜神经纤维层（RNFL）变化率（RoC）的影响。设计：前瞻性队列研究。参与者：110只眼睛，RNFL光学相干断层扫描≥4次，随访≥2年。方法：采用贝叶斯分层模型对全球RNFL RoC进行建模，并考虑受试者和行业水平的随机效应。在调整相关基线人口统计学和临床测量的预后模型中，研究了基线收缩压和舒张压测量及其与眼内压（IOP）的相互作用对全球RNFL变化率的影响。主要结果和测量：BP、IOP系数的大小和方向，以及它们对预测全球RNFL RoC的相互作用。单侧贝叶斯p值表示回归系数大于或小于零的后验概率，p 0.975定义显著性。结果：基线时平均（SD） 24-2视野平均偏差（MD）、随访时间和OCT扫描次数分别为-8.8 (6.0)dB、4.3（0.5）年和8.3（1.4）年。在多变量分析中，女性、西班牙裔（相对于白人）、较好的基线24-2 MD、每度12周期时较高的对比敏感度、糖尿病的存在和较厚的中央角膜预示着更快的RNFL变薄。调整协变量后，较低的舒张压合并较高的IOP预示着更快的RNFL变化率。合并收缩压的平行多变量模型显示了类似的效果。在各种BP/IOP组合中，IOP为第90百分位和舒张（收缩压）BP为第10百分位的眼睛的RNFL变薄速率最快（-0.554和-0.539 μm/年）。结论：基线时低血压和高IOP预示中枢性损伤或中晚期疾病的青光眼患者RNFL变化率更快（更差）。虽然在青光眼患者中控制血压可能有潜在的好处，但由于严格控制血压在降低心血管发病率和死亡率方面的益处已得到证实，因此控制血压对青光眼患者的治疗价值尚未确定。

{"title":"Association of Blood Pressure and Retinal Nerve Fiber Layer Rates of Thinning in Patients with Moderate to Advanced Glaucoma","authors":"Judy Figueroa BS , Erica Su PhD , Vahid Mohammadzadeh MD , Sajad Besharati MD , Massood Mohammadi MD , Maryam Ashrafkhorasani MD , Simon K. Law MD, PharmD , Anne L. Coleman MD, PhD , Joseph Caprioli MD , Robert E. Weiss PhD , Kouros Nouri-Mahdavi MD, MS","doi":"10.1016/j.ogla.2024.12.009","DOIUrl":"10.1016/j.ogla.2024.12.009","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the influence of baseline blood pressure (BP) on retinal nerve fiber layer (RNFL) rates of change (RoCs) in glaucoma patients with central damage or moderate to severe disease.</div></div><div><h3>Design</h3><div>Prospective cohort study.</div></div><div><h3>Participants</h3><div>One hundred ten eyes with ≥ 4 RNFL OCT scans and ≥ 2 years of follow-up.</div></div><div><h3>Methods</h3><div>Global RNFL RoCs were modeled with a Bayesian hierarchical model with subject- and sector-level random effects. Influence of baseline systolic and diastolic BP measures and their interactions with intraocular pressure (IOP) on global RNFL RoCs was investigated in prognostic models adjusting for relevant baseline demographic and clinical measures.</div></div><div><h3>Main Outcome Measures</h3><div>Magnitude and direction of coefficients for BP, IOP, and their interaction for prediction of global RNFL RoCs. One-sided Bayesian <em>P</em> values denote posterior probability that a regression coefficient is greater than or less than zero, with <em>P</em> < 0.025 or <em>P</em> > 0.975 defining significance.</div></div><div><h3>Results</h3><div>Average (standard deviation) 24-2 visual field mean deviation (MD) at baseline, follow-up time, and number of OCT scans were −8.8 (6.0) dB, 4.3 (0.5) years, and 8.3 (1.4), respectively. In multivariable analyses, female sex, Hispanic ethnicity (vs. White ethnicity), better baseline 24-2 MD, higher contrast sensitivity at 12 cycles per degree, presence of diabetes, and thicker central cornea predicted faster RNFL thinning. Adjusted for covariates, lower diastolic BP combined with higher IOP predicted faster RNFL RoCs. Parallel multivariable models incorporating systolic BP showed similar effects. Among various BP/IOP combinations, eyes with IOP at the 90th percentile and diastolic (systolic) BP at 10th percentile demonstrated the fastest RNFL thinning rates (−0.554 and −0.539 μm/year).</div></div><div><h3>Conclusions</h3><div>Low BP and higher IOP at baseline predicted faster (worse) RNFL RoCs in glaucoma patients with central damage or moderate to advanced disease. Although there may be potential benefits to BP management in glaucoma patients, the therapeutic value of BP manipulation in glaucoma patients is yet to be established given the proven benefits of tight BP control in reducing cardiovascular morbidity and mortality.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"8 3","pages":"Pages 285-292"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of a Novel Head-mounted Perimeter vs. the Humphrey Field Analyzer 新型头戴式周长仪与汉弗莱场强分析仪的比较。

IF 2.8 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2025-05-01 DOI: 10.1016/j.ogla.2024.11.007

Wisam O. Najdawi BS , Fangfang Jiang MSc , Gideon K.D. Zamba PhD , Chris A. Johnson PhD , Andrew E. Pouw MD

Purpose

Perimetry is a critical tool for the diagnosis and monitoring of glaucomatous visual field defects. The Humphrey Field Analyzer (HFA) is a large, relatively expensive device that does not normally allow for examination outside of the clinic, and it can be ergonomically difficult to tolerate for some patients. The present study compared the novel Smart System Virtual Reality (SSVR) perimetric headset test to that of the HFA in a group of patients with glaucoma.

Design

Prospective comparative study.

Subjects

Seventy-two eyes from 36 patients with glaucoma recruited at the University of Iowa Hospitals and Clinics.

Methods

Patients completed both HFA and SSVR visual field tests on the same day, with the order of tests randomized. After completing both visual field tests, subjects completed a survey regarding their subjective experience using each perimeter. Visual fields were analyzed using a linear mixed model to assess differences between devices accounting for intereye correlation and Bland–Altman analysis.

Main Outcome Measures

Primary outcome measures included mean deviation (MD), pattern standard deviation (PSD), and test duration.

Results

No statistically significant difference in MD was observed between the SSVR (−7.17 ± 6.36 dB) and HFA (−6.88 ± 6.78 dB; P = 0.859). Statistically significant differences in PSD were observed between the SSVR (4.26 ± 2.37 dB) and HFA (6.38 ± 4.51 dB; P < 0.001) and test duration (323.44 ± 72.27 seconds and 372.20 ± 61.44 seconds, respectively; P < 0.001). Subjectively, the SSVR was the preferred perimeter by 88.5% of patients.

Conclusions

The SSVR headset is a novel visual field testing device that produces similar results to the HFA with a shorter testing duration. The SSVR was the preferred perimeter by the majority of patients. Future study is required to determine if the SSVR can identify visual field progression.

Financial Disclosure(s)

The author(s) have no proprietary or commercial interest in any materials discussed in this article.

目的：周边视力测定是诊断和监测青光眼视野缺损的重要工具。汉弗莱视野分析仪（Humphrey Field Analyzer，HFA）是一种大型、相对昂贵的设备，通常不允许在诊室外进行检查，而且从人体工程学角度来看，有些患者可能难以忍受。本研究对一组青光眼患者进行了新型智能系统虚拟现实（SSVR）周边测量耳机测试与 HFA 的比较：设计：前瞻性比较研究：方法：患者同时完成 HFA 和 SSVR 测试：患者在同一天完成 HFA 和 SSVR 视野测试，测试顺序随机。在完成这两项视野测试后，受试者填写了一份调查问卷，内容涉及他们使用每种视力表的主观感受。使用线性混合模型对视野进行分析，以评估不同设备之间的差异，并考虑到眼间相关性和布兰-阿尔特曼分析：主要结果测量指标包括平均偏差（MD）、模式标准偏差（PSD）和测试持续时间：结果：SSVR（-7.17±6.36 dB）和 HFA（-6.88±6.78，P=0.859）之间的 MD 无统计学差异。在 SSVR（4.26±2.37 dB）和 HFA（6.38±4.51，p=结论）之间观察到 PSD 有统计学意义的差异：SSVR 头戴式耳机是一种新型视野测试设备，其测试结果与 HFA 相似，但测试时间更短。SSVR是大多数患者的首选。今后还需要进行研究，以确定 SSVR 是否能识别视野进展。

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引用次数: 0

Protection from Steroid-Induced Glaucoma via iStent Inject in a Patient with Behçet’s Disease iStent注射剂对behalet病患者类固醇性青光眼的保护作用

IF 2.8 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2025-05-01 DOI: 10.1016/j.ogla.2024.12.001

Milton Louca MD , David Z. Wechsler MBBS (Hons), FRANZCO

引用次数: 0

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