Ophthalmology. Glaucoma最新文献_第8页

OCT Segmentation Errors with Bruch's Membrane Opening-Minimum Rim Width as Compared with Retinal Nerve Fiber Layer Thickness 与视网膜神经纤维层厚度相比，基底膜开口-最小边缘宽度的光学相干断层扫描分割误差。

IF 2.9 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2024-05-01 DOI: 10.1016/j.ogla.2023.12.002

Hongli Yang PhD, Jack P. Rees BA, Facundo G. Sanchez MD, Stuart K. Gardiner PhD, Steven L. Mansberger MD, MPH

Objective

To compare the magnitude and location of automated segmentation errors of the Bruch’s membrane opening-minimum rim width (BMO-MRW) and retinal nerve fiber layer thickness (RNFLT).

Design

Cross-sectional study.

Participants

We included 162 glaucoma suspect or open-angle glaucoma eyes from 162 participants.

Methods

We used spectral-domain optic coherence tomography (Spectralis 870 nm, Heidelberg Engineering) to image the optic nerve with 24 radial optic nerve head B-scans and a 12-degree peripapillary circle scan, and exported the native “automated segmentation only” results for BMO-MRW and RNFLT. We also exported the results after “manual refinement” of the measurements.

Main Outcome Measures

We calculated the absolute and proportional error globally and within the 12 30-degree sectors of the optic disc. We determined whether the glaucoma classifications were different between BMO-MRW and RNFLT as a result of manual and automatic segmentation.

Results

The absolute error mean was larger for BMO-MRW than for RNFLT (10.8 μm vs. 3.58 μm, P < 0.001). However, the proportional errors were similar (4.3% vs. 4.4%, P = 0.47). In a multivariable regression model, errors in BMO-MRW were not significantly associated with age, location, magnitude, or severity of glaucoma loss (all P ≥ 0.05). However, larger RNFLT errors were associated with the superior and inferior sector location, thicker nerve fiber layer, and worse visual field (all P < 0.05). Errors in BMO-MRW and RNFLT were not likely to occur in the same sector location (R² = 0.001; P = 0.15). With manual refinement, the glaucoma classification changed in 7.8% and 6.2% of eyes with BMO-MRW and RNFLT, respectively.

Conclusions

Both BMO-MRW and RNFLT measurements included segmentation errors, which did not seem to have a common location, and may result in differences in glaucoma classification.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

目的比较布氏膜开口-最小边缘宽度（BMO-MRW）和视网膜神经纤维层厚度（RNFLT）自动分割误差的大小和位置：横断面研究：我们纳入了来自 162 名参与者的 162 只青光眼疑似眼或开角型青光眼眼：我们使用光谱域光学相干断层成像仪（Spectralis 870 nm，海德堡工程公司，德国海德堡）对视神经进行成像，包括 24 个径向视神经头 B 扫描和 12 度毛细血管周围圆扫描，并导出 BMO-MRW 和 RNFLT 的 "仅自动分割 "原始结果。我们还导出了 "手动细化 "测量后的结果：我们计算了全球和视盘 12 个 30 度扇区内的绝对误差和比例误差。我们确定了 BMO-MRW 和 RNFLT 的青光眼分类是否因手动和自动分割而有所不同：BMO-MRW的绝对误差平均值大于RNFLT（10.8μm vs. 3.58μm，p2=0.001；p=0.15）。通过人工细化，分别有 7.8% 和 6.2% 的眼睛的 BMO-MRW 和 RNFLT 的青光眼分类发生了变化：结论：BMO-MRW 和 RNFLT 测量都包含分割误差，这些误差似乎没有共同的位置，可能导致青光眼分类的差异。

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引用次数: 0

Long-term Treatment Outcomes for Malignant Glaucoma 恶性青光眼的长期治疗效果。

IF 2.9 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2024-05-01 DOI: 10.1016/j.ogla.2023.12.005

Sang Wook Jin MD , Joseph Caprioli MD

Purpose

To report the contributing factors to the successful long-term treatment outcomes of a large series of patients with malignant glaucoma (MG).

Design

Retrospective, interventional, consecutive case series.

Participants

This study used data collected from 1997 to 2022 from the Glaucoma Division of the Stein Eye Institute, University of California, Los Angeles (UCLA). All patients with MG who underwent treatment at UCLA were enrolled.

Methods

The following demographic and clinical data were collected and analyzed for their relevance to successful treatment: age, gender, ethnicity, glaucoma family history, visual acuity (VA), intraocular pressure (IOP), lens status, prior glaucoma diagnosis, prior ocular surgery, prior use of antiglaucoma agents, ultrasonic axial length, qualitative anterior chamber (AC) depth, and treatment methods and outcomes.

Main Outcome Measures

Anatomical success was defined as restoration of normal AC depth, indicating relief of the MG episode. Complete success was defined as anatomical success and the reduction of IOP to < 21 mmHg without further surgery, with or without medications.

Results

A total of 74 eyes of 73 patients were identified with a diagnosis of MG. The median (interquartile range) age of the patients at the time of MG presentation was 70 years (19.5) and 49 (75.4%) patients were female. The most common prior diagnosis before MG was primary angle closure glaucoma (PACG) (34 eyes, 51.5%). The initiating event for 30 eyes (45.5%) was glaucoma surgery and for 21 eyes (31.8%) was cataract surgery. Most eyes were pseudophakic (57, 86.4%). Fifty-six eyes underwent medical treatment; MG resolved in 2 eyes with medical treatment alone. Nine eyes (7 eyes = treatment naïve; 2 eyes = failed medical treatment) underwent laser treatment and MG resolved in 5 eyes. Among the 55 eyes which had surgical treatment, 52 eyes failed medical treatment and 3 eyes were treatment naïve. The anatomical success rate with surgical treatment was 96.4% and the most commonly performed surgical procedure was combined pars plana antero-central vitrectomy, hyaloido-zonulectomy, and iridectomy.

Conclusions

Female gender, PACG, and glaucoma surgery were predisposing factors for the development of MG. Medical treatment alone for MG was inadequate in the vast majority of cases. A surgical technique consisting of combined pars plana antero-central vitrectomy, hyaloido-zonulectomy and iridectomy consistently produced high long-term success.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

目的：报告一大批恶性青光眼（MG）患者成功获得长期治疗结果的诱因：设计：回顾性、介入性、连续性病例系列研究：本研究使用了加利福尼亚大学洛杉矶分校（UCLA）斯坦因眼科研究所青光眼部从 1997 年至 2022 年收集的数据。所有在加州大学洛杉矶分校接受治疗的 MG 患者均被纳入研究范围：方法：收集并分析以下人口统计学和临床数据，以确定其与成功治疗的相关性：年龄、性别、种族和青光眼家族史、视力（VA）、眼压（IOP）、晶状体状态、既往青光眼诊断、既往眼科手术、既往抗青光眼药物的使用、超声轴长、前房定性深度以及治疗方法和结果：解剖学成功的定义是前房深度恢复正常，表明 MG 病情缓解。完全成功的定义是：解剖学成功，眼压降至<21mmHg，无需进一步手术，用药或不用药：共有 73 名患者的 74 只眼睛被确诊为 MG。MG 患者发病时的中位年龄（四分位数间距）为 70 岁（19.5），49 名患者（75.4%）为女性。MG 之前最常见的诊断是原发性闭角型青光眼（PACG）（34 眼，51.5%）。30只眼睛（45.5%）的起因是青光眼手术，21只眼睛（31.8%）的起因是白内障手术。大多数眼球为假性角膜（57 眼，86.4%）。56 只眼睛接受了药物治疗，其中 2 只眼睛的 MG 在单纯药物治疗后得到缓解。九只眼（7 只眼为治疗无效眼；2 只眼为药物治疗失败眼）接受了激光治疗，其中 5 只眼的 MG 消失。在接受手术治疗的 55 只眼睛中，52 只眼睛药物治疗失败，3 只眼睛治疗失败。手术治疗的解剖学成功率为 96.4%，最常用的手术方法是联合平视前中央玻璃体切除术、透明带切除术和虹膜切除术：女性性别、PACG和青光眼手术是诱发MG的因素。在绝大多数病例中，仅靠药物治疗是不够的。由联合平视前中央玻璃体切除术、透明带切除术和虹膜切除术组成的手术技术始终保持着较高的长期成功率。

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引用次数: 0

Subepithelial Corneal Bullae after Posttrabeculectomy Ocular Digital Massage 小梁切除术后眼部数字按摩后的角膜上皮下囊泡

IF 2.9 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2024-03-01 DOI: 10.1016/j.ogla.2024.01.006

Hansen Dang BS, Nicole Radunzel BFA, CRA, Andrew Pouw MD

引用次数: 0

Optimal Performance of Selective Laser Trabeculoplasty 选择性激光小梁成形术的最佳性能瑞典最佳SLT多中心随机对照试验结果。

IF 2.9 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2024-03-01 DOI: 10.1016/j.ogla.2023.10.004

Tobias Dahlgren MD , Marcelo Ayala MD, PhD , Madeleine Zetterberg MD, PhD

Purpose

Selective laser trabeculoplasty (SLT) is a first-line treatment for glaucoma and ocular hypertension. However, due to insufficient comparative evidence in efficacy and safety, several SLT treatment protocols are currently used in practice. The objective of this trial was to compare the clinical outcomes of the 4 most significant SLT variants.

Design

Prospective, multicenter, masked, randomized controlled trial (RCT).

Participants

Four hundred patients with glaucoma or ocular hypertension. The cohort consisted of both treatment-naive patients and patients undergoing glaucoma treatment, at different stages of disease.

Methods

Selective laser trabeculoplasty was performed with 50 ± 5 laser spots in 180 degrees or with 100 ± 10 spots in 360 degrees. The laser power was titrated to either just below the cavitation bubble level (“standard energy”) or to a level producing cavitation bubbles at 50% to 75% of laser applications (“high energy”). Thus, 4 different treatment protocols were included – 180/standard, 180/high, 360/standard, and 360/high. The study adhered as close as possible to regular clinical management, but within a scientific framework.

Main Outcome Measures

Reduction of intraocular pressure (IOP) 1 to 6 months after SLT. The proportion of patients achieving a 20% IOP reduction without any further intervention. Time to glaucoma treatment escalation in a Kaplan–Meier survival analysis.

Results

SLT performed with the 360/high protocol was shown to be superior regarding all primary endpoints. The IOP reduction 1 to 6 months after SLT was 5.4 mmHg in the 360/high group, compared to 3.4, 3.2, and 4.2 mmHg with the 180/standard, 180/high, and 360/standard protocols, respectively (P < 0.001). Furthermore, the success rate after 6 months was significantly higher –58.3%, compared with 30.2%, 29.3%, and 41.7% (P < 0.001). The median time to glaucoma treatment escalation was more than twice as long with 360/high SLT –1323 days, compared to 437 days, 549 days, and 620 days (P < 0.001). Although postoperative discomfort was more frequent with the 360/high protocol, symptoms were generally mild and transient. Adverse events were rare in all groups.

Conclusions

The magnitude and longevity of SLT results increases substantially if SLT is performed according to the 360/high protocol, without compromising safety. Therefore, we recommend that 360/high SLT be considered as standard treatment.

Financial Disclosures

The authors have no proprietary or commercial interest in any materials discussed in this article.

目的：选择性激光小梁成形术（SLT）是青光眼和高眼压症的一线治疗方法。然而，由于疗效和安全性方面的比较证据不足，目前在实践中使用了几种SLT治疗方案。本试验的目的是比较四种最显著的SLT变体的临床结果。设计：前瞻性、多中心、掩蔽、随机对照试验。参与者：四百名青光眼或高眼压患者。该队列包括处于不同疾病阶段的治疗幼稚患者和接受青光眼治疗的患者。方法：SLT采用180度50±5个激光点，360度100±10个激光点。激光功率被滴定到刚好低于空化气泡水平（“标准能量”）或在50-75%的激光应用中产生空化气泡的水平（“高能量”）。因此，包括了四种不同的治疗方案——180/标准、180/高、360/标准和360/高。该研究尽可能接近常规临床管理，但在科学框架内。主要观察指标：SLT术后1-6个月眼压下降。在没有任何进一步干预的情况下实现20%IOP降低的患者比例。Kaplan-Meier生存分析中青光眼治疗升级的时间。结果：使用360/high方案进行的SLT在所有主要终点方面都显示出优越性。360/高组SLT后1-6个月的IOP降低为5.4 mmHg，而180/标准、180/高和360/标准方案的IOP分别为3.4、3.2和4.2 mmHg，结论：如果按照360/high方案进行SLT，在不影响安全性的情况下，SLT结果的幅度和寿命会显著增加。因此，我们建议将360/highSLT视为标准治疗。

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引用次数: 0

Early Outcomes of Combined Phacoemulsification and Ab Interno Tanito Microhook Trabeculotomy in Open-Angle Glaucoma 联合超声乳化和Ab Interno Tanito小钩小梁切除术治疗开角型青光眼的早期疗效。

IF 2.9 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2024-03-01 DOI: 10.1016/j.ogla.2023.10.007

Devendra Maheshwari MD , Davinder S. Grover MD, MPH , Rengappa Ramakrishnan DO, MS , Madhavi Ramanatha Pillai DNB , Drishti Chautani MBBS , Mohideen Abdul Kader PMT, DNB

Purpose

To study the early postoperative efficacy and safety of an Ab Interno microhook trabeculotomy (microLOT) combined with cataract surgery in patients with open-angle glaucoma.

Methods

This prospective, randomized, interventional study was conducted on consecutive patients with visually significant cataract and mild-moderate open-angle glaucoma. One hundred fourteen patients were included for analysis. The patients were randomized to undergo microhook trabeculotomy with phacoemulsification (group 1) or phacoemulsification alone (group 2). All patients were evaluated on postoperative day 1, 15, and 30, as well as 3, 6, and 12 months postoperatively. A P value < 0.05 was considered statistically significant. Baseline and follow-up visits were compared to determine significant differences in the number of antiglaucoma medications (AGMs), intraocular pressure (IOP), and best-corrected visual acuity.

Results

There were 57 patients in each group. The baseline characteristics were similar between the 2 groups, except the number of AGMs, which was greater in group 2. The mean preoperative IOP for group 1 (phaco-microLOT) was 26.5 mmHg ± 5.2 and group 2 (phaco-alone group) was 25.3 mmHg ± 3.1 which decreased to 12.5 mmHg ±3.6 (P < 0.001) and 20.0 mmHg ± 2.7(P < 0.001) at 12 months, respectively. Logarithm of the minimum angle of resolution visual acuity improved from 0.48 (interquartile range [IQR], 0.30–0.60) preoperatively to 0.00 (0.00–0.18) postoperatively (P < 0001) in group 1 and improved from 0.30 (IQR, 0.30–0.48) to 0.00 (0.00–0.00) in group 2 (P < 0.001). In group 1, the mean (standard deviation [SD]) AGM used preoperatively was 0.6 (0.9) which was significantly reduced to 0.2 (0.5) at 12 months postoperatively, whereas in group 2, at 12 months, the mean (SD) AGM used was reduced from 1.4 (0.6) to 1.1 (0.9). In group 1, 90.3% of eyes achieved complete success at the end of 1 year. The most common complication was hyphema, noted in 4 patients with 1 eye requiring an anterior chamber washout.

Conclusion

Ab interno microhook trabeculotomy (microLOT) combined with phacoemulsification in patients with open-angle glaucoma is an efficacious procedure with relatively minimal complications.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

目的：研究Ab Interno微钩小梁切开术（microLOT）联合白内障手术治疗开角型青光眼的术后早期疗效和安全性。方法：这项前瞻性、随机、介入性研究是对连续的视力显著白内障和轻度-中度开角型青光眼患者进行的。纳入114名患者进行分析。将患者随机分为微钩小梁切开术联合超声乳化术（第1组）或单独进行超声乳化手术（第2组）。所有患者均在术后第1、15和30天以及术后3个月、6和12个月进行评估。A p值结果：每组57例。两组的基线特征相似，只是第2组的AGM数量更多。第1组（超声乳化微滴）术前平均眼压为26.5 mmHg±5.2，第2组（单独超声乳化组）术前眼压为25.3 mmHg士3.1，降至12.5 mmHg±3.6。

{"title":"Early Outcomes of Combined Phacoemulsification and Ab Interno Tanito Microhook Trabeculotomy in Open-Angle Glaucoma","authors":"Devendra Maheshwari MD , Davinder S. Grover MD, MPH , Rengappa Ramakrishnan DO, MS , Madhavi Ramanatha Pillai DNB , Drishti Chautani MBBS , Mohideen Abdul Kader PMT, DNB","doi":"10.1016/j.ogla.2023.10.007","DOIUrl":"10.1016/j.ogla.2023.10.007","url":null,"abstract":"<div><h3>Purpose</h3><p><span><span>To study the early postoperative efficacy and safety of an Ab Interno microhook trabeculotomy (microLOT) combined with </span>cataract surgery </span>in patients with open-angle glaucoma.</p></div><div><h3>Methods</h3><p><span>This prospective, randomized, interventional study was conducted on consecutive patients with visually significant cataract and mild-moderate open-angle glaucoma. One hundred fourteen patients were included for analysis. The patients were randomized to undergo microhook trabeculotomy with phacoemulsification (group 1) or phacoemulsification alone (group 2). All patients were evaluated on postoperative day 1, 15, and 30, as well as 3, 6, and 12 months postoperatively. A </span><em>P</em><span><span> value < 0.05 was considered statistically significant. Baseline and follow-up visits were compared to determine significant differences in the number of antiglaucoma medications (AGMs), intraocular pressure (IOP), and best-corrected </span>visual acuity.</span></p></div><div><h3>Results</h3><p>There were 57 patients in each group. The baseline characteristics were similar between the 2 groups, except the number of AGMs, which was greater in group 2. The mean preoperative IOP for group 1 (phaco-microLOT) was 26.5 mmHg ± 5.2 and group 2 (phaco-alone group) was 25.3 mmHg ± 3.1 which decreased to 12.5 mmHg ±3.6 (<em>P</em> < 0.001) and 20.0 mmHg ± 2.7(<em>P</em> < 0.001) at 12 months, respectively. Logarithm of the minimum angle of resolution visual acuity improved from 0.48 (interquartile range [IQR], 0.30–0.60) preoperatively to 0.00 (0.00–0.18) postoperatively (<em>P</em> < 0001) in group 1 and improved from 0.30 (IQR, 0.30–0.48) to 0.00 (0.00–0.00) in group 2 (<em>P</em><span> < 0.001). In group 1, the mean (standard deviation [SD]) AGM used preoperatively was 0.6 (0.9) which was significantly reduced to 0.2 (0.5) at 12 months postoperatively, whereas in group 2, at 12 months, the mean (SD) AGM used was reduced from 1.4 (0.6) to 1.1 (0.9). In group 1, 90.3% of eyes achieved complete success at the end of 1 year. The most common complication was hyphema<span>, noted in 4 patients with 1 eye requiring an anterior chamber washout.</span></span></p></div><div><h3>Conclusion</h3><p>Ab interno microhook trabeculotomy (microLOT) combined with phacoemulsification in patients with open-angle glaucoma is an efficacious procedure with relatively minimal complications.</p></div><div><h3>Financial Disclosure(s)</h3><p>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 2","pages":"Pages 123-130"},"PeriodicalIF":2.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interim Analysis of Clinical Outcomes with Open versus Closed Conjunctival Implantation of the XEN45 Gel Stent XEN45凝胶支架开放式和闭合式结膜植入术的中期临床结果分析。

IF 2.9 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2024-03-01 DOI: 10.1016/j.ogla.2023.09.001

Elyse J. McGlumphy MD , Anna Do MD , Amy Du MD , Earl Randy Craven MD , Lawrence S. Geyman MD , Leo Shen MS , Joel S. Schuman MD , Joseph F. Panarelli MD

Objective

To examine the longitudinal postoperative outcomes of open versus closed conjunctiva implantation of the XEN45 gel stent.

Design

Retrospective multicenter study.

Subjects

One hundred ninety-three patients with glaucoma underwent XEN45 implantation via an open or closed conjunctiva approach.

Methods

Data on patient demographics; diagnoses; preoperative and postoperative clinical data; outcome measures, including intraocular pressure (IOP); use of glaucoma medications; visual acuity; and complications were collected. Statistical analyses were performed with P < 0.05 as significant.

Main Outcome Measures

Failure was defined as < 20% reduction in IOP from the medicated baseline or a IOP of > 21 mmHg at 2 consecutive visits at postoperative month 1 and beyond, the need for subsequent operative intervention or additional glaucoma surgery, or a catastrophic event, such as loss of light perception. Eyes that had not failed by these criteria and were not on glaucoma medications were considered complete successes. Overall success was defined as those who achieved success either with or without topical medications.

Results

Patients were followed for an average of 17 months. Complete success was achieved in 42.5% and 24.7% of the open and closed groups, respectively (P = 0.01). Overall success was achieved in 64.2% and 37.0% of the open and closed groups, respectively (P < 0.001) at the last follow-up. Bleb needling was performed in 12.4% of eyes in the open group compared with 40% of eyes in the closed group. An IOP spike of ≥ 10 mmHg was twice as likely to occur in the closed group compared with the open group during the postoperative period (40% vs. 18%; P = 0.001).

Conclusions

Implantation of XEN45 with opening of the conjunctiva resulted in a lower IOP with greater success and lower needling rate compared with those achieved with the closed conjunctiva technique. Similar rates of postoperative complications and vision loss were noted in each group. Although both procedures provide substantial IOP reduction, the open technique appears to result in higher success rates and fewer postoperative interventions.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

目的：观察XEN45凝胶支架开放式和封闭式结膜植入术的纵向术后效果。设计：回顾性多中心研究。受试者：193名青光眼患者通过开放或闭合结膜方法接受XEN45植入术。方法：患者人口统计数据；诊断；术前和术后临床数据；结果测量，包括眼压；青光眼药物的使用；视力；并收集并发症。进行统计学分析，P＜0.05为显著性。主要结果指标：失败被定义为IOP比药物基线降低<20%，或在术后第1个月及以后连续2次访视时IOP>21mmHg，需要后续手术干预或额外的青光眼手术，或灾难性事件，如光感丧失。未达到这些标准且未服用青光眼药物的眼睛被视为完全成功。总体成功被定义为那些在使用或不使用局部药物的情况下取得成功的人。结果：患者平均随访17个月。开放组和封闭组的完全成功率分别为42.5%和24.7%（P=0.01）。最后一次随访时，开放组和闭合组的总成功率分别是64.2%和37.0%（P<0.001）。开孔组12.4%的眼睛进行了Bleb针刺，而闭孔组的这一比例为40%。术后，与开放组相比，封闭组出现≥10mmHg眼压峰值的可能性是开放组的两倍（40%对18%；P=0.001）。结论：与封闭结膜技术相比，开放结膜植入XEN45可降低眼压，成功率更高，针刺率更低。各组术后并发症和视力下降的发生率相似。尽管这两种手术都能显著降低眼压，但开放式技术似乎能带来更高的成功率和更少的术后干预。财务披露：专有或商业披露可在本文末尾的脚注和披露中找到。

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引用次数: 0

Plate and Tube Rotation of the Glaucoma Drainage Implant: An Unusual Complication 青光眼引流植入物的板和管旋转：不寻常的并发症

IF 2.9 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2024-03-01 DOI: 10.1016/j.ogla.2023.12.001

Arnav Panigrahi MD, Siddhartha Rao BS, MBBS, Viney Gupta MD

引用次数: 0

Artifacts in OCT Retinal Nerve Fiber Layer Imaging in Patients with Boston Keratoprosthesis Type 1 波士顿1型角膜瓣患者的光学相干断层扫描视网膜神经纤维层成像中的伪影。

IF 2.9 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2024-03-01 DOI: 10.1016/j.ogla.2023.09.004

Alexandra G. Castillejos MD , Julia Devlin BS , Chhavi Saini MD , Jessica A. Sun BA , Mengyu Wang PhD , Grace Johnson BA , James Chodosh MD, MPH , Lucy Q. Shen MD

Purpose

To determine the clinical utility of OCT retinal nerve fiber layer (OCT RNFL) imaging for glaucoma evaluation in patients with Boston keratoprosthesis type 1 (KPro) by investigating imaging artifacts.

Design

Case-control study.

Subjects

Patients with KPro and without KPro (controls) matched for age, gender, and glaucoma diagnosis.

Methods

The most recent Cirrus OCT RNFL scan from 1 eye was categorized as having good signal strength (SS; ≥ 6 out of 10) or poor SS (< 6). Those with good SS were analyzed by 2 independent reviewers for artifacts. Images with good SS and no artifacts affecting the scanning circle were considered useful for glaucoma evaluation.

Main Outcome Measures

The incidence of poor SS and artifacts in OCT RNFL images; patient characteristics associated with useful scans.

Results

Sixty-five patients with KPro and 75 controls were included; 89.2% of KPro patients and 89.3% of control subjects had glaucoma (P = 0.98). Forty percent of KPro patients and 5.3% of controls had poor SS (P < 0.001). The proportion of images with either poor SS or artifacts was similar in KPro (76.9%) vs. controls (72.0%, P = 0.51). The most common artifacts in both groups were missing data (43.6%, 53.2%, respectively, P = 0.32) and motion artifact (25.6%, 19.7%, respectively, P = 0.47). Images were useful for glaucoma evaluation in 43.1% of KPro patients and in 69.3% of controls (P = 0.002). In the KPro group, patients with useful OCT scans, compared with those without, had better visual acuity (0.4 ± 0.3 vs. 0.9 ± 0.7 logarithm of the minimum angle of resolution, P = 0.004), and did not have congenital corneal pathologies (0.0% vs. 24.3%, P = 0.008). A multivariate analysis showed that KPro patients with older age had higher odds of useful OCT images (odds ratio, 1.05; P = 0.03). Among KPro patients with useful OCT scans, retinal nerve fiber layer thickness correlated with observed cup-to-disc ratio (Pearson correlation: r = −0.42, P = 0.03).

Conclusions

The rate of OCT RNFL images with either poor signal strength or artifacts in the KPro and control population was comparable. In patients with KPro, where intraocular pressure measurements are difficult and glaucoma is highly prevalent and often severe, OCT RNFL imaging can be useful for glaucoma evaluation.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

目的：通过研究成像伪影，确定光学相干断层扫描视网膜神经纤维层（OCT-RNFL）成像在波士顿1型角膜假体（KPro）患者青光眼评估中的临床应用。设计：病例对照研究。受试者：患有KPro和未患有KPro的患者（对照组）的年龄、性别和青光眼诊断相匹配。方法：一只眼睛最近的Cirrus OCT RNFL扫描被归类为信号强度良好（SS；≥6/10）或SS较差（主要结果指标：OCT RNFL图像中SS不良和伪影的发生率；与有用扫描相关的患者特征（p结论：在KPro和对照人群中，OCT RNFL图像信号强度差或伪影的发生率相当。在KPro患者中，眼压测量困难，青光眼非常普遍且往往很严重，OCT RN FL成像可用于青光眼评估。

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引用次数: 0

Re: Castillejos et al.: Artifacts in OCT retinal nerve fiber layer imaging in patients with Boston Keratoprosthesis Type 1 (Ophthalmol Glaucoma. 2024;7:206-215) Re：Castillejos et al：波士顿角膜前膜 1 型患者 OCT 视网膜神经纤维层成像中的伪影（Ophthalmol.Glaucoma.doi: 10.1016/j.ogla.2023.09.004.Online ahead of print.).

IF 2.9 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2024-03-01 DOI: 10.1016/j.ogla.2023.11.003

André S. Pollmann MD, FRCSC, Chloé Akl, Mona Harissi-Dagher MD, FRCSC

引用次数: 0

Six-Year Incidence and Risk Factors for Primary Open-Angle Glaucoma and Ocular Hypertension 原发性开角型青光眼和眼压升高的六年发病率和风险因素

IF 2.9 Q1 OPHTHALMOLOGY

Ophthalmology. Glaucoma

Pub Date : 2024-03-01 DOI: 10.1016/j.ogla.2023.08.003

Sahil Thakur MBBS, MS , Raghavan Lavanya MRCS , Marco Yu PhD , Yih-Chung Tham PhD , Zhi Da Soh BOptom, MPH , Zhen Ling Teo MBBS, MRCS , Victor Koh MBBS, MMed , Shivani Majithia OD , Chaoxu Qian MD, PhD , Tin Aung FRCSEd, PhD , Monisha E. Nongpiur MD, PhD , Ching-Yu Cheng MD, PhD

Objective

To determine the incidence and risk factors for primary open-angle glaucoma (POAG) and ocular hypertension (OHT) in a multiethnic Asian population.

Design

Population-based cohort study.

Participants

The Singapore Epidemiology of Eye Diseases study included 10 033 participants in the baseline examination between 2004 and 2011. Of those, 6762 (response rate = 78.8%) participated in the 6-year follow-up visit between 2011 and 2017.

Methods

Standardized examination and investigations were performed, including slit lamp biomicroscopy, intraocular pressure (IOP) measurement, pachymetry, gonioscopy, optic disc examination and static automated perimetry. Glaucoma was defined according to a combination of clinical evaluation, ocular imaging (fundus photo, visual field, and OCT) and criteria given by International Society of Geographical and Epidemiological Ophthalmology. OHT was defined on the basis of elevated IOP over the upper limit of normal; i.e., 20.4 mmHg, 21.5 mmHg, and 22.6 mmHg for the Chinese, Indian, and Malay cohort respectively, without glaucomatous optic disc change.

Main Outcome Measures

Incidence of POAG, OHT, and OHT progression.

Results

The overall 6-year age-adjusted incidences of POAG and OHT were 1.31% (95% confidence interval [CI], 1.04–1.62) and 0.47% (95% CI, 0.30–0.70). The rate of progression of baseline OHT to POAG at 6 years was 5.32%. Primary open-angle glaucoma incidence was similar (1.37%) in Chinese and Indians and lower (0.80%) in Malays. Malays had higher incidence (0.79%) of OHT than Indians (0.38%) and Chinese (0.37%). Baseline parameters associated with higher risk of POAG were older age (per decade: odds ratio [OR], 1.90; 95% CI, 1.54–2.35; P < 0.001), higher baseline IOP (per mmHg: OR, 1.20; 95% CI, 1.12–1.29; P < 0.001) and longer axial length (per mm: OR, 1.22; 95% CI, 1.07–1.40, P = 0.004).

Conclusion

Six-year incidence of POAG was 1.31% in a multiethnic Asian population. Older age, higher IOP, and longer axial length were associated with higher risk of POAG. These findings can help in future projections and guide public healthcare policy decisions for screening at-risk individuals.

Financial Disclosure(s)

The authors have no proprietary or commercial interest in any materials discussed in this article.

目标确定多种族亚洲人群中原发性开角型青光眼（POAG）和眼压过高症（OHT）的发病率和风险因素。方法进行标准化的检查和检验，包括裂隙灯显微镜检查、眼压测量、眼底测量、眼底镜检查、视盘检查和静态自动周边测量。青光眼是根据临床评估、眼部成像（眼底照片、视野和 OCT）以及国际地理和流行病学眼科学会给出的标准综合定义的。眼压升高症的定义是眼压升高超过正常值上限，即结果经年龄调整后，POAG 和 OHT 的 6 年总发病率分别为 1.31%（95% 置信区间 [CI]，1.04-1.62）和 0.47%（95% 置信区间 [CI]，0.30-0.70）。基线 OHT 在 6 年后发展为 POAG 的比率为 5.32%。华人和印度人的原发性开角型青光眼发病率相似（1.37%），而马来人的发病率较低（0.80%）。马来人的开角型青光眼发病率（0.79%）高于印度人（0.38%）和中国人（0.37%）。与较高的 POAG 风险相关的基线参数是年龄较大（每十年：几率比 [OR]，1.90；95% CI，1.54-2.35；P <；0.001）、基线眼压较高（每毫米汞柱：OR，1.20；95% CI，1.12-1.29；P <；0.001）和较长的轴向长度（每毫米：OR，1.22；95% CI，1.07-1.40，P = 0.004）。年龄越大、眼压越高、轴向长度越长，患 POAG 的风险越高。这些发现有助于未来的预测，并为筛查高危人群的公共医疗政策决策提供指导。

{"title":"Six-Year Incidence and Risk Factors for Primary Open-Angle Glaucoma and Ocular Hypertension","authors":"Sahil Thakur MBBS, MS , Raghavan Lavanya MRCS , Marco Yu PhD , Yih-Chung Tham PhD , Zhi Da Soh BOptom, MPH , Zhen Ling Teo MBBS, MRCS , Victor Koh MBBS, MMed , Shivani Majithia OD , Chaoxu Qian MD, PhD , Tin Aung FRCSEd, PhD , Monisha E. Nongpiur MD, PhD , Ching-Yu Cheng MD, PhD","doi":"10.1016/j.ogla.2023.08.003","DOIUrl":"10.1016/j.ogla.2023.08.003","url":null,"abstract":"<div><h3>Objective</h3><p>To determine the incidence and risk factors for primary open-angle glaucoma (POAG) and ocular hypertension (OHT) in a multiethnic Asian population.</p></div><div><h3>Design</h3><p>Population-based cohort study.</p></div><div><h3>Participants</h3><p>The Singapore Epidemiology of Eye Diseases study included 10 033 participants in the baseline examination between 2004 and 2011. Of those, 6762 (response rate = 78.8%) participated in the 6-year follow-up visit between 2011 and 2017.</p></div><div><h3>Methods</h3><p><span><span><span><span>Standardized examination and investigations were performed, including slit lamp biomicroscopy<span>, intraocular pressure (IOP) measurement, </span></span>pachymetry<span>, gonioscopy<span>, optic disc examination and static automated </span></span></span>perimetry. Glaucoma was defined according to a combination of </span>clinical evaluation, </span>ocular imaging<span> (fundus photo, visual field, and OCT) and criteria given by International Society of Geographical and Epidemiological Ophthalmology. OHT was defined on the basis of elevated IOP over the upper limit of normal; i.e., 20.4 mmHg, 21.5 mmHg, and 22.6 mmHg for the Chinese, Indian, and Malay cohort respectively, without glaucomatous optic disc change.</span></p></div><div><h3>Main Outcome Measures</h3><p>Incidence of POAG, OHT, and OHT progression.</p></div><div><h3>Results</h3><p>The overall 6-year age-adjusted incidences of POAG and OHT were 1.31% (95% confidence interval [CI], 1.04–1.62) and 0.47% (95% CI, 0.30–0.70). The rate of progression of baseline OHT to POAG at 6 years was 5.32%. Primary open-angle glaucoma incidence was similar (1.37%) in Chinese and Indians and lower (0.80%) in Malays. Malays had higher incidence (0.79%) of OHT than Indians (0.38%) and Chinese (0.37%). Baseline parameters associated with higher risk of POAG were older age (per decade: odds ratio [OR], 1.90; 95% CI, 1.54–2.35; <em>P</em> < 0.001), higher baseline IOP (per mmHg: OR, 1.20; 95% CI, 1.12–1.29; <em>P</em> < 0.001) and longer axial length (per mm: OR, 1.22; 95% CI, 1.07–1.40, <em>P</em> = 0.004).</p></div><div><h3>Conclusion</h3><p>Six-year incidence of POAG was 1.31% in a multiethnic Asian population. Older age, higher IOP, and longer axial length were associated with higher risk of POAG. These findings can help in future projections and guide public healthcare policy decisions for screening at-risk individuals.</p></div><div><h3>Financial Disclosure(s)</h3><p>The authors have no proprietary or commercial interest in any materials discussed in this article.</p></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 2","pages":"Pages 157-167"},"PeriodicalIF":2.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10295269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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