Ophthalmology. Glaucoma最新文献

{"title":"Insight on the Optic Nerve and Ahmed Valve Tube through a Type II Keratoprosthesis","authors":"Irene Koc BS , Demetrios G. Vavvas MD, PhD , Teresa C. Chen MD","doi":"10.1016/j.ogla.2024.06.006","DOIUrl":"10.1016/j.ogla.2024.06.006","url":null,"abstract":"","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 6","pages":"Page e13"},"PeriodicalIF":2.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Chan et al.: Effect of preoperative trabecular meshwork pigmentation and other eye characteristics on outcomes of combined phacoemulsification/minimally invasive glaucoma surgery (Ophthalmol Glaucoma. 2024; 7:271-281)","authors":"Vitor Porto de Souza MD , Fábio Nishimura Kanadani MD, PhD , Augusto Paranhos Jr. MD, PhD , Tiago Santos Prata MD, PhD","doi":"10.1016/j.ogla.2024.08.006","DOIUrl":"10.1016/j.ogla.2024.08.006","url":null,"abstract":"","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 6","pages":"Page e7"},"PeriodicalIF":2.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brief Report on 12-Month Outcomes of the ab Interno Gel Stent Using the Intraoperative Posterior Sweep of Tenons (PoST) Technique","authors":"Angela Liu BS , Lauren Dhar MD , Sarah Hung BS , Ronald Fellman MD , Davinder S. Grover MD, MPH","doi":"10.1016/j.ogla.2024.06.002","DOIUrl":"10.1016/j.ogla.2024.06.002","url":null,"abstract":"","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 6","pages":"Pages 624-626"},"PeriodicalIF":2.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between Statin Use and Glaucoma in the All of Us Research Program","authors":"Samuel Y. Lee BA ,&nbsp;Megan E. Paul BA ,&nbsp;Anne L. Coleman MD, PhD ,&nbsp;Ken Kitayama MD, PhD ,&nbsp;Fei Yu PhD ,&nbsp;Deyu Pan MS ,&nbsp;Victoria L. Tseng MD, PhD","doi":"10.1016/j.ogla.2024.07.008","DOIUrl":"10.1016/j.ogla.2024.07.008","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate associations between statin use and glaucoma in the 2017 to 2022 <em>All of Us</em> (<em>AoU</em>) Research Program.</div></div><div><h3>Design</h3><div>Cross-sectional, population-based.</div></div><div><h3>Participants</h3><div>79 742 adult participants aged ≥40 years with hyperlipidemia and with electronic health record (EHR) data in the <em>AoU</em> database.</div></div><div><h3>Methods</h3><div>Hyperlipidemia, glaucoma status, and statin use were defined by diagnoses and medication information in EHR data collected by <em>AoU</em>. Logistic regression analysis was performed to evaluate the association between statin use and glaucoma likelihood. Logistic regression modeling was used to examine associations between glaucoma and all covariates included in adjusted analysis. Serum low-density lipoprotein cholesterol (LDL-C) was used to assess hyperlipidemia severity. Analyses stratified by LDL-C level and age were performed.</div></div><div><h3>Main Outcome Measures</h3><div>Any glaucoma as defined by International Classification of Diseases codes found in EHR data.</div></div><div><h3>Results</h3><div>Of 79 742 individuals with hyperlipidemia in <em>AoU</em>, there were 6365 (8.0%) statin users. Statin use was associated with increased glaucoma prevalence when compared with statin nonuse (adjusted odds ratio [aOR]: 1.13, 95% confidence interval [CI]: 1.01–1.26). Higher serum levels of LDL-C were associated with increased odds of glaucoma (aOR: 1.003, 95% CI: 1.003, 1.004). Statin users had significantly higher LDL-C levels compared to nonusers (144.9 mg/dL versus 136.3 mg/dL, <em>P</em> value &lt; 0.001). Analysis stratified by LDL-C identified positive associations between statin use and prevalence of glaucoma among those with optimal (aOR = 1.39, 95% CI = 1.05–1.82) and high (aOR = 1.37, 95% CI = 1.09–1.70) LDL-C levels. Age-stratified analysis showed a positive association between statin use and prevalence of glaucoma in individuals aged 60 to 69 years (aOR = 1.28, 95% CI = 1.05–1.56).</div></div><div><h3>Conclusions</h3><div>Statin use was associated with increased glaucoma likelihood in the overall adult <em>AoU</em> population with hyperlipidemia, in individuals with optimal or high LDL-C levels, and in individuals 60 to 69 years old. Findings suggest that statin use may be an independent risk factor for glaucoma, which may furthermore be affected by one’s lipid profile and age.</div></div><div><h3>Financial Disclosures</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 6","pages":"Pages 563-571"},"PeriodicalIF":2.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior Capsular Pigment Deposition in a Case of Pigmentary Glaucoma","authors":"Madhuri Manapakkam MS, DNB,&nbsp;Deepa Ramamoorthy MS,&nbsp;Neethu Mohan MS","doi":"10.1016/j.ogla.2024.04.001","DOIUrl":"10.1016/j.ogla.2024.04.001","url":null,"abstract":"","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 6","pages":"Page e9"},"PeriodicalIF":2.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Factors Associated with the Risk of Glaucoma Suspect Conversion to Glaucoma","authors":"Jo-Hsuan Wu MD ,&nbsp;Willam Halfpenny MB BChir, MEng ,&nbsp;Jennifer Bu MD ,&nbsp;Manreet Brar BS ,&nbsp;Robert N. Weinreb MD ,&nbsp;Sally L. Baxter MD, MSc","doi":"10.1016/j.ogla.2024.06.007","DOIUrl":"10.1016/j.ogla.2024.06.007","url":null,"abstract":"<div><h3>Purpose</h3><div>To examine social factors associated with the 5-year risk of glaucoma suspects (GS) converting to open-angle glaucoma (OAG).</div></div><div><h3>Design</h3><div>Retrospective cohort analysis.</div></div><div><h3>Subjects</h3><div>We screened for participants diagnosed with GS in the <em>All of Us</em> database. Cases that converted to OAG within 5 years of GS diagnosis (the “conversion group”) were compared with control cases that did not convert.</div></div><div><h3>Methods</h3><div>Demographic, socioeconomic and health-care utilization data of the cases were extracted and compared between the conversion group and the control group. Multivariable Cox proportional hazards modeling was used to identify potential factors associated with the risk of conversion.</div></div><div><h3>Main Outcome Measures</h3><div>Hazard ratios (HRs) of significant factors associated with the risk of conversion.</div></div><div><h3>Results</h3><div>A total of 5274 GS participants were identified, and 786 (15%) cases converted to OAG within 5-year follow-up. The 2 groups showed significant differences in age, race, gender, employment status, income/education level, history of intraocular surgery, and health-care utilization patterns. In the multivariable model, African American/Black race (HR : 1.70 [95% confidence interval (CI), 1.44–2.00]), older age at GS diagnosis (1.17 [95% CI, 1.09–1.25]), male gender (1.30 [95% CI, 1.13–1.50], no history of recreational drug use (1.23 [1.07–1.42]), history of intraocular surgery (1.60 [95% CI, 1.02–1.53]), and having more reasons for delayed health-care access (2.27 [95% CI, 1.23–4.18]) were associated with a greater hazard of conversion, while being employed (0.71 [95% CI, 0.60–0.86]) was associated with a smaller hazard of conversion (<em>P</em> &lt; 0.05 for all).</div></div><div><h3>Conclusions</h3><div>Several social factors were associated with the conversion from GS to OAG, which may help to identify patients at higher risk of disease progression. Future studies are needed to examine the basis for these findings and the potential interventions that could address them.</div></div><div><h3>Financial Disclosures</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 6","pages":"Pages 551-562"},"PeriodicalIF":2.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Ultrasound Biomicroscopy Study of Acute Hydrops in Neonatal Glaucoma with Sturge–Weber Syndrome","authors":"Madhu Sharma MS, DNB,&nbsp;Samridhi Vohra MBBS,&nbsp;Sushmita Kaushik MS, FAICO","doi":"10.1016/j.ogla.2024.05.002","DOIUrl":"10.1016/j.ogla.2024.05.002","url":null,"abstract":"","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 6","pages":"Page e12"},"PeriodicalIF":2.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial and Ethnic Differences in the Prevalence and Treatment Patterns for Neovascular Glaucoma in the American Academy of Ophthalmology IRIS® Registry","authors":"Victoria L. Tseng MD, PhD ,&nbsp;Deyu Pan MS ,&nbsp;Ken Kitayama MD, PhD ,&nbsp;Fei Yu PhD ,&nbsp;Anne L. Coleman MD, PhD","doi":"10.1016/j.ogla.2024.07.006","DOIUrl":"10.1016/j.ogla.2024.07.006","url":null,"abstract":"<div><h3>Purpose</h3><div>To examine racial and ethnic differences in the prevalence and treatment patterns for neovascular glaucoma (NVG) in at-risk individuals in the American Academy of Ophthalmology (Academy) IRIS® Registry (Intelligent Research in Sight).</div></div><div><h3>Design</h3><div>Observational retrospective cohort study.</div></div><div><h3>Participants</h3><div>Eyes in the IRIS Registry with a retinal ischemia based on a history of proliferative diabetic retinopathy, retinal vein occlusion, and/or ocular ischemic syndrome.</div></div><div><h3>Methods</h3><div>Race and ethnicity was defined as Asian, Black, Hispanic/Latino, non-Hispanic White, and other/unknown. In eyes with retinal ischemia, the outcome was NVG. In eyes with NVG, outcomes included treatment of retinal ischemia with pan-retinal photocoagulation (PRP), and surgery to lower intraocular pressure (IOP) with trabeculectomy, tube shunt, and cyclophotocoagulation (CPC). Covariates included age, sex, region of residence, insurance type, smoking status, and systemic and ocular comorbidities. Cox proportional hazards regression was used to examine adjusted associations between race and ethnicity and NVG and each type of NVG treatment.</div></div><div><h3>Main Outcome Measures</h3><div>Incidence of NVG, PRP, trabeculectomy, tube shunt, CPC, and any IOP-lowering surgery.</div></div><div><h3>Results</h3><div>Of 312 106 eyes with retinal ischemia, there were 5885 (1.9%) with NVG. Compared to eyes of individuals who identified as non-Hispanic White, eyes of individuals who were Black and Hispanic/Latino had higher hazards of NVG in adjusted analyses (hazards ratio [HR] = 1.28, 95% confidence interval [CI] = 1.15–1.43 [for Black]; HR = 1.32, 95% CI = 1.17–1.47 [for Hispanic/Latino]). Compared with eyes of individuals who were non-Hispanic White, there was higher hazards of trabeculectomy in eyes of individuals who were Hispanic/Latino (adjusted HR = 1.91, 95% CI = 1.08–3.39) and higher hazards of tube shunt (adjusted HR = 1.35, 95% CI = 1.07–1.69) and of any IOP-lowering surgery (adjusted HR = 1.29, 95% CI = 1.09–1.53) in eyes of individuals who were Black. There were no statistically significant differences in the hazards of PRP or CPC.</div></div><div><h3>Conclusions</h3><div>Eyes of Black and Hispanic/Latino individuals with retinal ischemia in the IRIS Registry had higher likelihood of NVG and of IOP-lowering surgery for NVG. Further study is needed to examine the medical and social factors that preclude optimal management of diabetic eye disease, in order to prevent its blinding complications.</div></div><div><h3>Financial Disclosures</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 6","pages":"Pages 615-623"},"PeriodicalIF":2.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Nonreturn after Loss to Follow-Up from Glaucoma Care","authors":"Lauren M. Wasser MD ,&nbsp;Julie Cassidy BA ,&nbsp;Hsing-Hua Sylvia Lin PhD ,&nbsp;Andrew M. Williams MD","doi":"10.1016/j.ogla.2024.07.007","DOIUrl":"10.1016/j.ogla.2024.07.007","url":null,"abstract":"<div><h3>Purpose</h3><div>Loss to follow-up (LTFU) in primary open-angle glaucoma (POAG) can lead to undertreatment, disease progression, and irreversible vision loss. Patients who become LTFU either eventually re-establish glaucoma care after a lapse or never return to the clinic. The purpose of this study is to examine a large population of patients with POAG who became LTFU to determine the proportion that return to care and to identify demographic and clinical factors associated with nonreturn after LTFU.</div></div><div><h3>Design</h3><div>Retrospective longitudinal cohort study.</div></div><div><h3>Participants</h3><div>Patients with a diagnosis of POAG with a clinical encounter in 2014 in the IRIS® Registry (Intelligent Research in Sight).</div></div><div><h3>Methods</h3><div>We examined follow-up patterns for 553 663 patients with POAG who had an encounter in the IRIS Registry in 2014 by following their documented clinic visits through 2019. LTFU was defined as exceeding 1 calendar year without an encounter. Within the LTFU group, patients were classified as returning after a lapse in care (return after LTFU) or not (nonreturn after LTFU).</div></div><div><h3>Main Outcome Measures</h3><div>Proportion of patients with nonreturn after LTFU and baseline demographic and clinical characteristics associated with nonreturn among LTFU patients with POAG.</div></div><div><h3>Results</h3><div>Among 553 663 patients with POAG, 277 019 (50%) had at least 1 episode of LTFU over the 6-year study period. Within the LTFU group, 33% (92 471) returned to care and 67% (184 548) did not return to care. Compared to those who returned to care, LTFU patients with nonreturn were more likely to be older (age &gt;80 years; relative risk [RR] = 1.48; 95% confidence interval [CI]: 1.47–1.50), to have unknown/missing insurance (RR = 1.31; 95% CI: 1.30–1.33), and to have severe-stage POAG (RR = 1.13; 95% CI: 1.11–1.15). Greater POAG severity and visual impairment were associated with nonreturn with a dose-dependent relationship in the adjusted model that accounted for demographic characteristics. Among those with return after LTFU, almost all returned within 2 years of last appointment (82 201; 89%) rather than 2 or more years later.</div></div><div><h3>Conclusions</h3><div>Half of patients with POAG in the IRIS Registry had at least 1 period of LTFU, and two thirds of LTFU patients with POAG did not return to care. More effort is warranted to re-engage the vulnerable patients with POAG who become LTFU.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 6","pages":"Pages 572-579"},"PeriodicalIF":2.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Incidence and Presentation Features of Glaucoma in Vogt–Koyanagi–Harada Syndrome","authors":"Abdelaziz Abdelaal MD ,&nbsp;Abdul Rhman Hassan MD ,&nbsp;Basant E. Katamesh MD ,&nbsp;Mennatullah Mohamed Eltaras MD ,&nbsp;Hashem Abu Serhan MD","doi":"10.1016/j.ogla.2024.06.005","DOIUrl":"10.1016/j.ogla.2024.06.005","url":null,"abstract":"<div><h3>Topic</h3><div>To determine the cumulative incidence and features of glaucoma in patients with Vogt–Koyanagi–Harada (VKH) syndrome compared with nonglaucoma patients.</div></div><div><h3>Clinical Relevance</h3><div>Knowing the exact burden of secondary glaucoma in VKH could guide its screening and management in clinical practice as a part of the regular follow-up for patients with VKH.</div></div><div><h3>Methods</h3><div>The review protocol was preregistered on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PROSPERO) [CRD42023462794]. PubMed, Scopus, Web of Science, EBSCOhost, and Google Scholar were searched for studies reporting the cumulative incidence and features of glaucoma presentation in VKH. A manual search was also conducted to supplement the primary search. Subgroup analyses based on glaucoma type, VKH stage, and patients’ age were conducted. All analyses were conducted using STATA. Fixed- and random-effects models were selected according to the observed heterogeneity. Studies’ methodological quality was determined using the National Institutes of Health tool.</div></div><div><h3>Results</h3><div>The analysis of 7084 eyes revealed a progressive increase in the cumulative incidence of secondary glaucoma over time. The cumulative incidence was lowest at VKH onset (7%) and highest at 15 years (26%). Open-angle (12%; 95% confidence interval [CI]: 9%–14%) is more common than angle-closure glaucoma (7%; 95% CI: 3%–13%). Glaucoma cumulative incidence is highest in the chronic recurrent stage of VKH (33%; 95% CI: 12%–59%) and among children &lt; 18 years of age (26%; 95% CI: 16%–37%). Features associated with glaucoma occurrence in VKH showed comparable rates with nonglaucoma cases. However, a meta-analysis to determine risk factors of glaucoma development in VKH was not feasible secondary to the lack of adjusted risk measures in included studies. Studies' quality was questionable in 5 studies. The certainty of evidence was moderate-to-high.</div></div><div><h3>Conclusion</h3><div>The cumulative incidence of glaucoma increases throughout VKH’s course, with a higher tendency in children, chronic recurrent stages, and long-term follow-up. Future research should focus on examining risk factors of glaucoma development in VKH through adjusted multivariable regression models.</div></div><div><h3>Financial Disclosure(s)</h3><div>The author(s) have no proprietary or commercial interest in any materials discussed in this article.</div></div>","PeriodicalId":19519,"journal":{"name":"Ophthalmology. Glaucoma","volume":"7 6","pages":"Pages 587-601"},"PeriodicalIF":2.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}