Pub Date : 2019-08-29DOI: 10.19080/omcij.2019.08.555747
Francis M. Agwom
The biological activity of schiff base cut across a range of activities, it is therefore called a versatile Pharmacophore [1]. One of the major activity or the most reported activity of schiff bases is their antibacterial activity [1,2]. Some scholars have also synthesized some analogues of isoniazid imines and tested them against many pathogenic bacteria [3-6]. Another prominent research on the computational studies of imines is that of isoniazid – ketoprofen co-drug imine [7].
{"title":"In Silico Studies, Comparative Synthesis and Antibacterial Activity of Some Imine Derivatives of Isonicotinic Hydrazide","authors":"Francis M. Agwom","doi":"10.19080/omcij.2019.08.555747","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555747","url":null,"abstract":"The biological activity of schiff base cut across a range of activities, it is therefore called a versatile Pharmacophore [1]. One of the major activity or the most reported activity of schiff bases is their antibacterial activity [1,2]. Some scholars have also synthesized some analogues of isoniazid imines and tested them against many pathogenic bacteria [3-6]. Another prominent research on the computational studies of imines is that of isoniazid – ketoprofen co-drug imine [7].","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83906597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-19DOI: 10.19080/omcij.2019.08.555746
M. Beghalia
Struvite or magnesium ammonium phosphate hexahydrate (MAP) is one of the components of urinary stone. It forms in human beings as a result of urinary tract infection with urea splitting organisms. These stones can grow rapidly forming “staghorn-calculi”, which is a painful urological disorder. Therefore, it is of prime importance to study the growth and inhibition of struvite crystals. In the present work, we have exanimated the interactions between the enzyme urease and two inhibitors (aluminum and citrate acid) by molecular modeling methods. The results show that the presence of aluminum or citrate acid significantly affects struvite crystal growth. It suggested that our inhibitors induced morphology changes that reflect the interactions between the inhibitor and the crystal surfaces at a molecular level. Similar changes were observed in the presence of identical concentrations of citrate acid, and aluminum, emphasizing the unique interaction of phosphocitrate with the struvite crystal.
{"title":"Prevention of Crystallization in Stones Infection by Chemical Inhibitors","authors":"M. Beghalia","doi":"10.19080/omcij.2019.08.555746","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555746","url":null,"abstract":"Struvite or magnesium ammonium phosphate hexahydrate (MAP) is one of the components of urinary stone. It forms in human beings as a result of urinary tract infection with urea splitting organisms. These stones can grow rapidly forming “staghorn-calculi”, which is a painful urological disorder. Therefore, it is of prime importance to study the growth and inhibition of struvite crystals. In the present work, we have exanimated the interactions between the enzyme urease and two inhibitors (aluminum and citrate acid) by molecular modeling methods. The results show that the presence of aluminum or citrate acid significantly affects struvite crystal growth. It suggested that our inhibitors induced morphology changes that reflect the interactions between the inhibitor and the crystal surfaces at a molecular level. Similar changes were observed in the presence of identical concentrations of citrate acid, and aluminum, emphasizing the unique interaction of phosphocitrate with the struvite crystal.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78447062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-09DOI: 10.19080/omcij.2019.08.555745
Paulo Nuno Martins
Pierre Alfred Laurent was born in Saint-Louis (Upper-Rhine) in 1909 in France. It is known that he was an important chemist in the first half of the twentieth century. Thus, in the early 1950s, through an invitation made by the Portuguese Government, Pierre Laurent came to Lisbon in order to teach all subjects about organic chemistry to students of chemical Engineering course at Instituto Superior Técnico (the largest engineering school in Portugal) [1].
皮埃尔·艾尔弗雷德·洛朗1909年出生于法国的圣路易(上莱茵河)。众所周知，他是二十世纪上半叶一位重要的化学家。因此，在20世纪50年代初，应葡萄牙政府的邀请，皮埃尔·洛朗来到里斯本，在葡萄牙最大的工程学校——高等理工学院(Instituto Superior tsamicnico)为化学工程课程的学生讲授有机化学的所有科目。
{"title":"A Brief Biography of Pierre Alfred Laurent: A Distinguished Chemist from the Instituto Superior Técnico","authors":"Paulo Nuno Martins","doi":"10.19080/omcij.2019.08.555745","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555745","url":null,"abstract":"Pierre Alfred Laurent was born in Saint-Louis (Upper-Rhine) in 1909 in France. It is known that he was an important chemist in the first half of the twentieth century. Thus, in the early 1950s, through an invitation made by the Portuguese Government, Pierre Laurent came to Lisbon in order to teach all subjects about organic chemistry to students of chemical Engineering course at Instituto Superior Técnico (the largest engineering school in Portugal) [1].","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"31 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90088020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-30DOI: 10.19080/omcij.2019.08.555744
Alfeen M A
{"title":"New Development Method for Determination of Cefuroxime Axetil (CUA) and Cefprozil (CZ) In Pharmaceutical Drugs By RP-HPLC","authors":"Alfeen M A","doi":"10.19080/omcij.2019.08.555744","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555744","url":null,"abstract":"","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82656720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-25DOI: 10.19080/omcij.2019.08.555743
Beghalia Mohamed
Medicinal plants are still a source of medical care in developing countries in the absence of a modern medical system. Morocco is one of the Mediterranean countries with a long medical tradition and traditional know-how based on medicinal plants. Indeed, traditional medicine has always occupied an important place in the traditions of medication in Morocco; the rural commune of Imi n’Tlit is a concrete example. However, the intensive exploitation of plant species for medicinal purposes may become harmful if it exceeds the threshold of sustainable regeneration by the resources used [1].
{"title":"The Potential Capacity of Ten Plant Extracts on Calcium Oxalate Formation In -Vitro Study","authors":"Beghalia Mohamed","doi":"10.19080/omcij.2019.08.555743","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555743","url":null,"abstract":"Medicinal plants are still a source of medical care in developing countries in the absence of a modern medical system. Morocco is one of the Mediterranean countries with a long medical tradition and traditional know-how based on medicinal plants. Indeed, traditional medicine has always occupied an important place in the traditions of medication in Morocco; the rural commune of Imi n’Tlit is a concrete example. However, the intensive exploitation of plant species for medicinal purposes may become harmful if it exceeds the threshold of sustainable regeneration by the resources used [1].","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75730210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-03DOI: 10.19080/omcij.2019.08.555742
Etim E E
Antimicrobial resistance to therapeutic drugs is already widespread globally and the number is on the rapid increase. Pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE) and many others are becoming resistant to several established antibiotics [1]. The list of drug resistant pathogens also extends to organisms such as Staphylococcus aureus and enterococcus which are found to be resistant to antibiotics such as oxacillin, penicillin, amoxicillin, methicillin, cephalosporins, gentamicin, erythromycin and trimethoprim, vancomycin, ampicillin, and gentamicin. In addition, gram negative organisms like Escherichia coli, Shigellaflexeneri, Pseudomonas aeruginosa, Salmonella typhi and Gram-positive Bacillus subtilis bacterial strains. Candida albicans, Aspergillus flavus, Fusarium solani, and Candida glaberata are among some fungal pathogens showing resistance feature against established drugs [1].
{"title":"Phytochemical Complexes Towards Solving Multi-Drug Resistance: An Overview","authors":"Etim E E","doi":"10.19080/omcij.2019.08.555742","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555742","url":null,"abstract":"Antimicrobial resistance to therapeutic drugs is already widespread globally and the number is on the rapid increase. Pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE) and many others are becoming resistant to several established antibiotics [1]. The list of drug resistant pathogens also extends to organisms such as Staphylococcus aureus and enterococcus which are found to be resistant to antibiotics such as oxacillin, penicillin, amoxicillin, methicillin, cephalosporins, gentamicin, erythromycin and trimethoprim, vancomycin, ampicillin, and gentamicin. In addition, gram negative organisms like Escherichia coli, Shigellaflexeneri, Pseudomonas aeruginosa, Salmonella typhi and Gram-positive Bacillus subtilis bacterial strains. Candida albicans, Aspergillus flavus, Fusarium solani, and Candida glaberata are among some fungal pathogens showing resistance feature against established drugs [1].","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"164 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86425345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-03DOI: 10.19080/omcij.2019.08.555741
Jose Enrique Herbert Pucheta
Figure 1: OIV Member States (Reproduced from [4]). iii) Creating statistics and relevant meta-data bases of world’s vitis-vinis sectors describing their complex dynamics and iv) formation of qualified human resources [1]. Each year, a set of hundreds of novel resolution projects are proposed and peer reviewed by world’s certified experts coming from all OIV Member states (Figure 1) as well as by certified observers such as from the Oenological Products and Practices International Association (Oennopia, [2]) or the International Federation of Wines and Spirits (FIVS [3]).
{"title":"Spectroscopy in Wine Industry OEno-NMR: Recent Advances of Nuclear Magnetic Resonance","authors":"Jose Enrique Herbert Pucheta","doi":"10.19080/omcij.2019.08.555741","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555741","url":null,"abstract":"Figure 1: OIV Member States (Reproduced from [4]). iii) Creating statistics and relevant meta-data bases of world’s vitis-vinis sectors describing their complex dynamics and iv) formation of qualified human resources [1]. Each year, a set of hundreds of novel resolution projects are proposed and peer reviewed by world’s certified experts coming from all OIV Member states (Figure 1) as well as by certified observers such as from the Oenological Products and Practices International Association (Oennopia, [2]) or the International Federation of Wines and Spirits (FIVS [3]).","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86951814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-29DOI: 10.19080/omcij.2019.08.555740
Abiche Ekalu
{"title":"Isolation and Microbial Screening of 1-Methylcyclopentene from Bracystelma Togoense Schtlr","authors":"Abiche Ekalu","doi":"10.19080/omcij.2019.08.555740","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555740","url":null,"abstract":"","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74764297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-20DOI: 10.19080/omcij.2019.08.555739
Krishna sarmapathy
Efavirenz, L-743725((+)-enantiomer), DMP-266, L-741211(racemate), L-743726, Stocrin, Sustiva (S)-(-)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one. Now India recommends efavirenz (EFV)based antiretroviral treatment (ART) to treat HIV, which is currently cheaper than DTG-based ART. However, as pharmaceutical licenses on DTG are now lifting in India, generic versions of DTG are likely to bring its cost close to that of EFV. Research from the USA and Europe, where DTG is recommended as the first option for treatment, suggests DTG has more tolerable side effects, can enable people to suppress HIV levels quickly and is less likely to lead to drug resistance [3].
{"title":"NNRTI (Non-Nucleoside Reverse Transcriptase Inhibitor) Drug AZT and Their Preparation & Determination A Patent Evaluation of Efavirenz","authors":"Krishna sarmapathy","doi":"10.19080/omcij.2019.08.555739","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555739","url":null,"abstract":"Efavirenz, L-743725((+)-enantiomer), DMP-266, L-741211(racemate), L-743726, Stocrin, Sustiva (S)-(-)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one. Now India recommends efavirenz (EFV)based antiretroviral treatment (ART) to treat HIV, which is currently cheaper than DTG-based ART. However, as pharmaceutical licenses on DTG are now lifting in India, generic versions of DTG are likely to bring its cost close to that of EFV. Research from the USA and Europe, where DTG is recommended as the first option for treatment, suggests DTG has more tolerable side effects, can enable people to suppress HIV levels quickly and is less likely to lead to drug resistance [3].","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89908513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-12DOI: 10.19080/OMCIJ.2019.08.555738
A. Branton, M. Trivedi, Dahryn Trivedi, G. Nayak, S. Jana
Cefazolin sodium is a broad-spectrum first-generation cephalosporin antibiotic useful for the treatment of many bacterial infections. The aim of this research work was to estimate the impact of the Trivedi Effect® on the physicochemical and thermal properties of cefazolin using the modern analytical technique. Cefazolin sample was divided into control and treated parts. No Biofield Energy Treatment was provided to the control part of cefazolin; whereas, the treated part received Consciousness Energy Healing Treatment remotely by a distinguished Biofield Energy Healer, Alice Branton. The particle size values in the treated cefazolin were significantly increased by 11.44%(d10), 3.15%(d50), 2.35%(d90), and 2.42%{D(4,3)}; hence, the specific surface area was decreased by 4.54% compared to the control sample. The evaporation and decomposition temperature of the treated cefazolin was increased by 27.56% and 0.12%, respectively; however, the latent heat of evaporation and latent heat of decomposition was significantly altered by 1151.8% and -53.75%, respectively compared to the control cefazolin. The total weight loss was decreased by 6.57%, but the residue amount was significantly increased by 137.5% in the treated sample compared with the control sample. The maximum thermal degradation temperature of the 1st and 2nd peak was significantly altered by 5.58% and -28.66% in the treated sample compared with the control sample. The Consciousness Energy Healing Treatment might have introduced a new polymorphic form of cefazolin which may offer better powder flowability, smooth surface, and good thermal stability compared with the untreated sample. The treated cefazolin would be a more efficacious pharmaceutical formulation against cellulitis, urinary and respiratory tract infections, pneumonia, endocarditis, joint infection, genital infections, blood infections, etc.
{"title":"Evaluation of the Physicochemical and Thermal Properties of Consciousness Energy Healing Treated Cefazolin Sodium","authors":"A. Branton, M. Trivedi, Dahryn Trivedi, G. Nayak, S. Jana","doi":"10.19080/OMCIJ.2019.08.555738","DOIUrl":"https://doi.org/10.19080/OMCIJ.2019.08.555738","url":null,"abstract":"Cefazolin sodium is a broad-spectrum first-generation cephalosporin antibiotic useful for the treatment of many bacterial infections. The aim of this research work was to estimate the impact of the Trivedi Effect® on the physicochemical and thermal properties of cefazolin using the modern analytical technique. Cefazolin sample was divided into control and treated parts. No Biofield Energy Treatment was provided to the control part of cefazolin; whereas, the treated part received Consciousness Energy Healing Treatment remotely by a distinguished Biofield Energy Healer, Alice Branton. The particle size values in the treated cefazolin were significantly increased by 11.44%(d10), 3.15%(d50), 2.35%(d90), and 2.42%{D(4,3)}; hence, the specific surface area was decreased by 4.54% compared to the control sample. The evaporation and decomposition temperature of the treated cefazolin was increased by 27.56% and 0.12%, respectively; however, the latent heat of evaporation and latent heat of decomposition was significantly altered by 1151.8% and -53.75%, respectively compared to the control cefazolin. The total weight loss was decreased by 6.57%, but the residue amount was significantly increased by 137.5% in the treated sample compared with the control sample. The maximum thermal degradation temperature of the 1st and 2nd peak was significantly altered by 5.58% and -28.66% in the treated sample compared with the control sample. The Consciousness Energy Healing Treatment might have introduced a new polymorphic form of cefazolin which may offer better powder flowability, smooth surface, and good thermal stability compared with the untreated sample. The treated cefazolin would be a more efficacious pharmaceutical formulation against cellulitis, urinary and respiratory tract infections, pneumonia, endocarditis, joint infection, genital infections, blood infections, etc.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88741782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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