Pub Date : 2019-04-08DOI: 10.19080/omcij.2019.08.555737
Harutyunyan Artur A
Recently, we have developed a fundamentally new method of constructing the derivatives of the heterocyclic system of benzo[4′,5] imidazo[2′,1′:6,1]pyrido[2,3-d]pyrimidine [1], which allowed the introduction of methyl and methylene into the molecule groups. It should be noted that some derivatives of the indicated heterocyclic system revealed antibacterial and ant monoamine oxidase properties [2,3].
{"title":"Π-Extended Systems Based on Tetracyclic Benzo [4,5] Imidazo [2′,1′:6,1] Pyrido[2,3-D] Pyrimidines","authors":"Harutyunyan Artur A","doi":"10.19080/omcij.2019.08.555737","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555737","url":null,"abstract":"Recently, we have developed a fundamentally new method of constructing the derivatives of the heterocyclic system of benzo[4′,5] imidazo[2′,1′:6,1]pyrido[2,3-d]pyrimidine [1], which allowed the introduction of methyl and methylene into the molecule groups. It should be noted that some derivatives of the indicated heterocyclic system revealed antibacterial and ant monoamine oxidase properties [2,3].","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"37 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91438315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-14DOI: 10.19080/omcij.2019.08.555736
A. Mm
Green, efficient and clean synthesis of a Schiff base ligand, 1-(((1H-1,2,4-triazol-3-yl) imino) methyl) naphthalen-2-ol (TMN) has been synthesized in equimolar reaction (1:1) of 3-amino-1,2,4-triazole as a primary amine and 2-hydroxy-1-naphthaldehyde as an aldehyde using microwave irradiation technique. The synthesized Schiff base ligand was then reacted with four transition metal ions Co(II), Ni(II), Cu(II) and Zn(II) in 1:1 molar ratio of ligand and metal acetate using microwave technique. The stereochemistry and the bonding characteristics of the ligand and its metal complexes were achieved based on elemental analysis, FT-IR, UV-Vis., NMR and ESR as well as Thermo-Gravimetric Analysis (TGA). The thermal dehydration and decomposition of Co (II), Ni(II) and Cu(II) complexes were studied kinetically using the integral method applying the Coats-Redfern and Horowitz Metzger equations. The antimicrobial activities of ligand and its Zn (II) complex were studied against the bacterial (positive and negative) grams and
{"title":"Green Synthesis, Spectral, Thermal Characterization and Biological Activity of Schiff base Ligand Derived from 3-amino-1,2,4-triazol and its Metal Complexes","authors":"A. Mm","doi":"10.19080/omcij.2019.08.555736","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555736","url":null,"abstract":"Green, efficient and clean synthesis of a Schiff base ligand, 1-(((1H-1,2,4-triazol-3-yl) imino) methyl) naphthalen-2-ol (TMN) has been synthesized in equimolar reaction (1:1) of 3-amino-1,2,4-triazole as a primary amine and 2-hydroxy-1-naphthaldehyde as an aldehyde using microwave irradiation technique. The synthesized Schiff base ligand was then reacted with four transition metal ions Co(II), Ni(II), Cu(II) and Zn(II) in 1:1 molar ratio of ligand and metal acetate using microwave technique. The stereochemistry and the bonding characteristics of the ligand and its metal complexes were achieved based on elemental analysis, FT-IR, UV-Vis., NMR and ESR as well as Thermo-Gravimetric Analysis (TGA). The thermal dehydration and decomposition of Co (II), Ni(II) and Cu(II) complexes were studied kinetically using the integral method applying the Coats-Redfern and Horowitz Metzger equations. The antimicrobial activities of ligand and its Zn (II) complex were studied against the bacterial (positive and negative) grams and","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82100962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-12DOI: 10.19080/omcij.2019.08.555734
Erick Cuevas Yañez
1,2,3-triazoles are easily prepared from CuAAC reaction and represent a potential source of antifungal compounds analogous to azole drugs. Accordingly, research groups have synthesized diverse 1,2,3-triazoles with modulated antifungal activity through the substituents in azide or alkyne precursors. A brief review of the state of the art about this topic is presented, focusing the increasing importance of developing new and more selective antifungal compounds.
{"title":"Design and Synthesis of Antifungal Compounds from 1,2,3-Triazoles through the Click Chemistry Approach","authors":"Erick Cuevas Yañez","doi":"10.19080/omcij.2019.08.555734","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555734","url":null,"abstract":"1,2,3-triazoles are easily prepared from CuAAC reaction and represent a potential source of antifungal compounds analogous to azole drugs. Accordingly, research groups have synthesized diverse 1,2,3-triazoles with modulated antifungal activity through the substituents in azide or alkyne precursors. A brief review of the state of the art about this topic is presented, focusing the increasing importance of developing new and more selective antifungal compounds.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73129759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-26DOI: 10.19080/omcij.2019.08.555732
Jian-Jhe Yang
Ammonia(NH 3 ) has played an essential role in meeting the increasing demand for food and the worldwide need of nitrogenous fertilizer since 1913. Unfortunately, the traditional Haber-Bosch process for producing NH 3 from nitrogen(N 2 ) is a high energy-consumption process. Under ambient conditions catalytic reducing N 2 to NH 3 is an attractive and promising alternative approach which would emerge huge opportunity to directly provide nitrogenous fertilizers in agricultural fields as need in a distributed manner. In this review, some research findings showed alterna -tive, available, sustainable NH 3 production processes from N 2 in the presence of electro-catalysts and photo-catalysts under ambient conditions.
{"title":"A Mini Review of Catalytic Reducing Nitrogen to Ammonia under Ambient Conditions","authors":"Jian-Jhe Yang","doi":"10.19080/omcij.2019.08.555732","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555732","url":null,"abstract":"Ammonia(NH 3 ) has played an essential role in meeting the increasing demand for food and the worldwide need of nitrogenous fertilizer since 1913. Unfortunately, the traditional Haber-Bosch process for producing NH 3 from nitrogen(N 2 ) is a high energy-consumption process. Under ambient conditions catalytic reducing N 2 to NH 3 is an attractive and promising alternative approach which would emerge huge opportunity to directly provide nitrogenous fertilizers in agricultural fields as need in a distributed manner. In this review, some research findings showed alterna -tive, available, sustainable NH 3 production processes from N 2 in the presence of electro-catalysts and photo-catalysts under ambient conditions.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91541769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-21DOI: 10.19080/OMCIJ.2019.08.555731
G. Nayak, M. Trivedi, A. Branton, Dahryn Trivedi, S. Jana
Ofloxacin is an antibiotic useful for the treatment of bacterial infections. The aim of this research work was to evaluate the impact of the Trivedi Effect®-Consciousness Energy Healing Treatment on the physicochemical properties of ofloxacin using modern analytical techniques. The sample was divided into control and Biofield Energy Treated parts. The control sample did not receive the Biofield Energy Treatment; whereas, the treated part received the Biofield Treatment remotely by a famous Biofield Energy Healer, Gopal Nayak. The PXRD peak intensities and crys-tallite sizes were significantly altered ranging from -39.33% to 127.93% and -68.28% to 21%, respectively; however, the average crystallite size of the treated ofloxacin (236.59nm) was decreased by 19.48% compared with the control sample (293.83nm). The particle size values were signifi-cantly decreased at d10 (10.67%), d50 (25%), d90 (24.4%), and D (4,3) (25.12%); thus, the specific surface area was significantly increased by 9.8% in the treated sample compared to the control sample. The latent heat of fusion and the latent heat of decomposition of the treated sample were significantly increased by 11.71% and 123.52%, respectively compared to the control sample. The total weight loss was significantly decreased by 10.59%; however, the residue amount was significantly increased by 63.29% in the treated ofloxacin compared with the control sample. The Trivedi Effect®-Consciousness Energy Healing Treatment generated a new polymorphic form of ofloxacin which may be more soluble, bioavail-able, and be thermally more stable compared to the untreated sample. The treated ofloxacin would be more efficacious against cellulitis, prosta-titis, chronic bronchitis, urinary tract infections, infections of the urethra and cervix, pneumonia, infectious diarrhoea, plague, etc.
{"title":"Spectroscopic and Calorimetric Evaluation of the Biofield Energy Healing Treated Ofloxacin","authors":"G. Nayak, M. Trivedi, A. Branton, Dahryn Trivedi, S. Jana","doi":"10.19080/OMCIJ.2019.08.555731","DOIUrl":"https://doi.org/10.19080/OMCIJ.2019.08.555731","url":null,"abstract":"Ofloxacin is an antibiotic useful for the treatment of bacterial infections. The aim of this research work was to evaluate the impact of the Trivedi Effect®-Consciousness Energy Healing Treatment on the physicochemical properties of ofloxacin using modern analytical techniques. The sample was divided into control and Biofield Energy Treated parts. The control sample did not receive the Biofield Energy Treatment; whereas, the treated part received the Biofield Treatment remotely by a famous Biofield Energy Healer, Gopal Nayak. The PXRD peak intensities and crys-tallite sizes were significantly altered ranging from -39.33% to 127.93% and -68.28% to 21%, respectively; however, the average crystallite size of the treated ofloxacin (236.59nm) was decreased by 19.48% compared with the control sample (293.83nm). The particle size values were signifi-cantly decreased at d10 (10.67%), d50 (25%), d90 (24.4%), and D (4,3) (25.12%); thus, the specific surface area was significantly increased by 9.8% in the treated sample compared to the control sample. The latent heat of fusion and the latent heat of decomposition of the treated sample were significantly increased by 11.71% and 123.52%, respectively compared to the control sample. The total weight loss was significantly decreased by 10.59%; however, the residue amount was significantly increased by 63.29% in the treated ofloxacin compared with the control sample. The Trivedi Effect®-Consciousness Energy Healing Treatment generated a new polymorphic form of ofloxacin which may be more soluble, bioavail-able, and be thermally more stable compared to the untreated sample. The treated ofloxacin would be more efficacious against cellulitis, prosta-titis, chronic bronchitis, urinary tract infections, infections of the urethra and cervix, pneumonia, infectious diarrhoea, plague, etc.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79309812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.19080/omcij.2019.08.555735
Neema Bisht, A. Sah
Discovery and development of a new drug is a very complex process as it takes long duration and various resources. The practice of drug discovery has been speeding up with the use of newer advanced techniques to increase the efficiency of the process. Various recent technologies like bioinformatics, computer-aided drug design (CADD), combinatorial chemistry has considerably extended its range of applications and spanning almost all stages in the drug discovery process. Chemical compounds can be screened out for their biological activity with target through high-throughput screening (HTS). Advanced technologies are using successfully now days due to speed up, low expenses and greater success rates in drug development. The main objective of this mini review is to highlight the utility of various recent trends in drug discovery.
{"title":"Impact of Recent Trends in Drug Discovery and Development","authors":"Neema Bisht, A. Sah","doi":"10.19080/omcij.2019.08.555735","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555735","url":null,"abstract":"Discovery and development of a new drug is a very complex process as it takes long duration and various resources. The practice of drug discovery has been speeding up with the use of newer advanced techniques to increase the efficiency of the process. Various recent technologies like bioinformatics, computer-aided drug design (CADD), combinatorial chemistry has considerably extended its range of applications and spanning almost all stages in the drug discovery process. Chemical compounds can be screened out for their biological activity with target through high-throughput screening (HTS). Advanced technologies are using successfully now days due to speed up, low expenses and greater success rates in drug development. The main objective of this mini review is to highlight the utility of various recent trends in drug discovery.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78186833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.19080/omcij.2019.08.555733
M. Kožurková
In this work, we investigated the human serum albumin binding behavior of a series of novel derivatives with both tacrine and coumarin pharmacophores. The compounds were investigated using UV-Vis absorption and fluorescence spectroscopy. KB values were found to be in order of 103 M-1. The values of n indicate that only one independent class of binding sites is available for tacrine-coumarin hybrids on HSA. Synchronous fluorescence spectra showed that compounds did not have any noticeably effect on α-helical conformation of HSA. Our data indicated that these tacrine-coumarin molecules exhibit promising potential which would be of considerable use in the development of drugs with enhanced or more selective effects and greater clinical efficacy.
{"title":"Spectroscopic Evaluation of Novel TacrineCoumarin Hybrids as HSA-Interacting Agents","authors":"M. Kožurková","doi":"10.19080/omcij.2019.08.555733","DOIUrl":"https://doi.org/10.19080/omcij.2019.08.555733","url":null,"abstract":"In this work, we investigated the human serum albumin binding behavior of a series of novel derivatives with both tacrine and coumarin pharmacophores. The compounds were investigated using UV-Vis absorption and fluorescence spectroscopy. KB values were found to be in order of 103 M-1. The values of n indicate that only one independent class of binding sites is available for tacrine-coumarin hybrids on HSA. Synchronous fluorescence spectra showed that compounds did not have any noticeably effect on α-helical conformation of HSA. Our data indicated that these tacrine-coumarin molecules exhibit promising potential which would be of considerable use in the development of drugs with enhanced or more selective effects and greater clinical efficacy.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81515150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-09DOI: 10.19080/omcij.2018.08.555730
Ayaz Mahmood Dar
A new series of substituted aromatic thiazolidinones [1-4]were synthesized by the reaction of acetophenone and its derivatives [5-8]with hydrazine hydrate and merceptoacetic acid in absolute ethanol in one pot manner. The striking feature of this reaction is the formation of hydrazone in situ which in turn undergoes the cyclization with mercepto acetic acid, leading to the formation of new thiazolidinones. Thus, the thiazolidinone ring closes at carbonyl carbon, by the attack of sulfur of mercaptoacetic acid moiety, preferentially from the front (β, axial) so that the nitrogen has an equatorial orientation (α, equatorial) to avoid steric repulsion, giving minimum steric hindrance. The new compounds were characterized by spectral (IR, 1 H NMR, 13 C NMR, MS) and analytical methods. The new compounds were screened for cytotoxicity (MTT assay) as well as genotoxicity (Comet assay) studies against different cancer cell lines, during which the new compounds depicted potential anticancer behaviour.
{"title":"Synthesis, Characterization and Cytotoxic Studies of New Thiazolidinones","authors":"Ayaz Mahmood Dar","doi":"10.19080/omcij.2018.08.555730","DOIUrl":"https://doi.org/10.19080/omcij.2018.08.555730","url":null,"abstract":"A new series of substituted aromatic thiazolidinones [1-4]were synthesized by the reaction of acetophenone and its derivatives [5-8]with hydrazine hydrate and merceptoacetic acid in absolute ethanol in one pot manner. The striking feature of this reaction is the formation of hydrazone in situ which in turn undergoes the cyclization with mercepto acetic acid, leading to the formation of new thiazolidinones. Thus, the thiazolidinone ring closes at carbonyl carbon, by the attack of sulfur of mercaptoacetic acid moiety, preferentially from the front (β, axial) so that the nitrogen has an equatorial orientation (α, equatorial) to avoid steric repulsion, giving minimum steric hindrance. The new compounds were characterized by spectral (IR, 1 H NMR, 13 C NMR, MS) and analytical methods. The new compounds were screened for cytotoxicity (MTT assay) as well as genotoxicity (Comet assay) studies against different cancer cell lines, during which the new compounds depicted potential anticancer behaviour.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81435608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.19080/omcij.2018.08.555729
Harutyunyan Artur A
Continuing research on the synthesis of biologically active quinazoline derivatives [1,2] in this report we have described the synthesis of previously unknown substituted 2-methylquinzolins and 2-[2-aryl(hetaryl)vinyl]quinazolines, which contain pharmacophore groups at different positions of the ring. Synthesis was carried out by the interaction of 2-methyl-4H-3,1-benzoxzin4-ones 1a, b with aromatic and heterocyclic amines, according to the Scheme 1.
{"title":"Synthesis of Substituted Quinazolines Containing Pharmacophoric Groups","authors":"Harutyunyan Artur A","doi":"10.19080/omcij.2018.08.555729","DOIUrl":"https://doi.org/10.19080/omcij.2018.08.555729","url":null,"abstract":"Continuing research on the synthesis of biologically active quinazoline derivatives [1,2] in this report we have described the synthesis of previously unknown substituted 2-methylquinzolins and 2-[2-aryl(hetaryl)vinyl]quinazolines, which contain pharmacophore groups at different positions of the ring. Synthesis was carried out by the interaction of 2-methyl-4H-3,1-benzoxzin4-ones 1a, b with aromatic and heterocyclic amines, according to the Scheme 1.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88704512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-28DOI: 10.19080/omcij.2018.08.555728
Manjunatha M N
using MoKα (0.71073 Å) radiation for the crystal. Intensity data was collected up to a max of 26.81° for the compound in the w–ф scan mode. The data was reduced using SAINTPLUS [8].
{"title":"Molecular Structure of Metal Complexes of Certain Benzimidazole Derivatives","authors":"Manjunatha M N","doi":"10.19080/omcij.2018.08.555728","DOIUrl":"https://doi.org/10.19080/omcij.2018.08.555728","url":null,"abstract":"using MoKα (0.71073 Å) radiation for the crystal. Intensity data was collected up to a max of 26.81° for the compound in the w–ф scan mode. The data was reduced using SAINTPLUS [8].","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76688883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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