Pub Date : 2018-09-27DOI: 10.19080/omcij.2018.08.555727
V. Raj
The main objective of present research hypothesis was to give the idea and taking the attention of researcher for tubulin as an anticancer drug target. Inhibiting tubulin by novel lead scaffold may be helpful to treat the cancer with reduced side effect and higher selectivity toward the cancer cells. The present problems with cancer drug have cancer cell resistant and adverse effects. Assisting the solution of this problem, we hypothesized; Pharmacophore based selection for new scaffold may exhibit better binding affinity and selectivity towards the tubulin assembly and suppressing microtubule formation and attenuating the adverse effects and resistant of drug molecules.
{"title":"New Utilities for Cancer Treatment to Inhibit Tubulin Assembly and Suppressing Microtubule Formation: Research Hypothesis","authors":"V. Raj","doi":"10.19080/omcij.2018.08.555727","DOIUrl":"https://doi.org/10.19080/omcij.2018.08.555727","url":null,"abstract":"The main objective of present research hypothesis was to give the idea and taking the attention of researcher for tubulin as an anticancer drug target. Inhibiting tubulin by novel lead scaffold may be helpful to treat the cancer with reduced side effect and higher selectivity toward the cancer cells. The present problems with cancer drug have cancer cell resistant and adverse effects. Assisting the solution of this problem, we hypothesized; Pharmacophore based selection for new scaffold may exhibit better binding affinity and selectivity towards the tubulin assembly and suppressing microtubule formation and attenuating the adverse effects and resistant of drug molecules.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84686261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-20DOI: 10.19080/omcij.2018.08.555726
Rowayda M Fouad
Asenapine maleate is a white to off-white non hygroscopic powder, slightly soluble in water (5.80 mg/mL) [1], sparingly soluble in 0.1 M HCl, soluble in methanol. The pH of a saturated asenapine solution in water is 4.2 at 23.5 0C, its pKa is 8.6. AS is atypical antipsychotic drug developed for the treatment of schizophrenia and acute mania associated with bipolar disorder [2]. It shows high affinity for numerous receptors like serotonin, adrenergic, dopamine, histamine [3]. Many methods have been mentioned in the literature for the determination of AS in pure form, in pharmaceutical formulation, as well as in biological fluids as, Titrimetric method [4], Spectrophotometric methods [5-8]. Gas chromatography [9], Liquid chromatography [10,11] and Thin layer chromatography [12]. Different HPLC methods using different mobile phases and detectors [13-24]. There were 5 stability indicating HPLC methods [25-29]. No electrochemical method was introduced for determination of asenapine. Ionselective electrodes have been used recently for quantitative determination of drugs as it has many advantages comparing to other sophisticated methods [30,31]. ISEs have low detection limit, good accuracy, wide concentration range and good applicability to turbid and coloured solutions. ISEs give high selectivity towards the drugs in the presence of different excipients. The proposed work introduces three different electrodes for the determination of asenapine maleate according to ICH guidelines [32]. The electrochemical sensitivity of the electrode is based on the incorporation of ion pair (AS-AR and AS–PTA) using PVC membrane and carbon paste (Figure 1). Figure 1: Chemical Structure of Asenapine Maleate.
{"title":"Potentiometric Determination of Asenapine Maleate Using PVC Membrane and Carbon Paste Ion-selective Electrodes","authors":"Rowayda M Fouad","doi":"10.19080/omcij.2018.08.555726","DOIUrl":"https://doi.org/10.19080/omcij.2018.08.555726","url":null,"abstract":"Asenapine maleate is a white to off-white non hygroscopic powder, slightly soluble in water (5.80 mg/mL) [1], sparingly soluble in 0.1 M HCl, soluble in methanol. The pH of a saturated asenapine solution in water is 4.2 at 23.5 0C, its pKa is 8.6. AS is atypical antipsychotic drug developed for the treatment of schizophrenia and acute mania associated with bipolar disorder [2]. It shows high affinity for numerous receptors like serotonin, adrenergic, dopamine, histamine [3]. Many methods have been mentioned in the literature for the determination of AS in pure form, in pharmaceutical formulation, as well as in biological fluids as, Titrimetric method [4], Spectrophotometric methods [5-8]. Gas chromatography [9], Liquid chromatography [10,11] and Thin layer chromatography [12]. Different HPLC methods using different mobile phases and detectors [13-24]. There were 5 stability indicating HPLC methods [25-29]. No electrochemical method was introduced for determination of asenapine. Ionselective electrodes have been used recently for quantitative determination of drugs as it has many advantages comparing to other sophisticated methods [30,31]. ISEs have low detection limit, good accuracy, wide concentration range and good applicability to turbid and coloured solutions. ISEs give high selectivity towards the drugs in the presence of different excipients. The proposed work introduces three different electrodes for the determination of asenapine maleate according to ICH guidelines [32]. The electrochemical sensitivity of the electrode is based on the incorporation of ion pair (AS-AR and AS–PTA) using PVC membrane and carbon paste (Figure 1). Figure 1: Chemical Structure of Asenapine Maleate.","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88597045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-05-29DOI: 10.19080/OMCIJ.2018.06.555700
A. Sunil
The most powerful technique to determine quantitatively and separate the mixture of composition in today’s modern chemistry is Chromatography especially High Performance Liquid Chromatography or High Pressure Liquid Chromatography [1]. HPLC works on the principle of Affinity chromatography. The solution of the sample is injected into a column of a porous material (stationary phase) and a liquid (mobile phase) is pumped at high pressure through the column. The mixture on travelling through the stationary phase splits into its constituents and the component with high affinity for stationary phase travels late whereas one with less affinity elutes fast. This is also based partition coefficient of the material [2]. Abstract
{"title":"HPLC Detectors, Their Types and Use: A Review","authors":"A. Sunil","doi":"10.19080/OMCIJ.2018.06.555700","DOIUrl":"https://doi.org/10.19080/OMCIJ.2018.06.555700","url":null,"abstract":"The most powerful technique to determine quantitatively and separate the mixture of composition in today’s modern chemistry is Chromatography especially High Performance Liquid Chromatography or High Pressure Liquid Chromatography [1]. HPLC works on the principle of Affinity chromatography. The solution of the sample is injected into a column of a porous material (stationary phase) and a liquid (mobile phase) is pumped at high pressure through the column. The mixture on travelling through the stationary phase splits into its constituents and the component with high affinity for stationary phase travels late whereas one with less affinity elutes fast. This is also based partition coefficient of the material [2]. Abstract","PeriodicalId":19547,"journal":{"name":"Organic & Medicinal Chemistry International Journal","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84354889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：