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A Novel Device for Vergence Exercises: Testing Automatic Dual Rotational Risley Prisms on Asymptomatic Adults and Patients with Convergence Insufficiency. 用于辐辏练习的新型设备:在无症状成人和辐辏障碍患者身上测试自动双旋转 Risley 棱镜。
IF 2.6 3区 医学 Q2 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1007/s40123-024-01055-1
Ya-Yu Chen, Yun-Shao Hu, Shuan-Yu Huang, Tzu-Hsun Tsai

Introduction: This study investigated the effects of automatic dual rotational Risley prisms (ADRRPs), a mobile phone application-operated device, on vergence abilities in young adults.

Methods: Fifty-six participants aged 20-24 performed vergence exercises. The test group used prisms with power changes from 30Δ base-out to 10Δ base-in, while the control group used plano lenses for 10 min. Ophthalmic examinations included lateral heterophoria, near point of convergence (NPC), vergence facility (VF), negative fusional vergence (NFV), and positive fusional vergence (PFV), all measured before and after the vergence exercises. Pre- and post-test results were analyzed using a paired sample t test. Additionally, three cases with convergence insufficiency (CI) performed similar exercises for 12 weeks.

Results: Participants were divided into the test group (n = 39; age 21.82 ± 1.10 years) and control group (n = 17; age 20.53 ± 0.51 years). In the test group, NPC improved from 6.11 ± 2.52 cm to 5.77 ± 2.30 cm (p = 0.023). VF increased from 13.75 ± 4.10 cpm to 16.50 ± 4.42 cpm (p = 0.007). PFV at 6 m and 0.4 m increased from 19.49 ± 6.77∆ to 22.19 ± 6.64∆ (p < 0.001) and 20.51 ± 7.05∆ to 22.69 ± 6.44∆ (p = 0.012), respectively. After 12 weeks, convergence insufficiency symptom survey scores for cases with CI decreased significantly, with NPC improving from 7.0 to 0 cm, 6.0 to 5.8 cm, and 6.0 to 4.7 cm. PFV increased from 10 to 25∆, 20 to 30∆, and 25 to 50∆.

Conclusion: This preliminary study showed the effect of ADRRPs on improving vergence abilities. Further studies are needed to investigate the long-term sustainability and effects in a larger population of individuals with CI of this approach.

简介:本研究调查了自动双旋转瑞斯利棱镜(ADRRPs)这一手机应用操作设备对青少年视力的影响:本研究调查了自动双旋转瑞斯利棱镜(ADRRPs)--一种由手机应用软件操作的设备--对青壮年辐辏能力的影响:方法:56 名 20-24 岁的参与者进行了辐辏练习。测试组使用的三棱镜功率变化范围从基底向外30Δ到基底向内10Δ,而对照组则使用平光镜10分钟。眼科检查包括侧方异视、近辐辏点(NPC)、辐辏功能(VF)、负性融合辐辏(NFV)和正性融合辐辏(PFV),均在辐辏训练前后进行测量。测试前后的结果采用配对样本 t 检验进行分析。此外,三名辐辏功能不全(CI)患者也进行了为期 12 周的类似练习:参与者分为测试组(39 人;年龄 21.82 ± 1.10 岁)和对照组(17 人;年龄 20.53 ± 0.51 岁)。在测试组中,NPC 从 6.11 ± 2.52 厘米降至 5.77 ± 2.30 厘米(p = 0.023)。VF 从 13.75 ± 4.10 cpm 增加到 16.50 ± 4.42 cpm(P = 0.007)。6 米和 0.4 米处的 PFV 从 19.49 ± 6.77∆ 增加到 22.19 ± 6.64∆ (p 结论:这一初步研究表明,ADT 对心肌梗死的治疗效果显著:这项初步研究表明,ADRRPs 对提高辐辏能力有一定作用。还需要进一步研究这种方法在更多 CI 患者中的长期可持续性和效果。
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引用次数: 0
Assessing the Correlation Between Retinal Arteriolar Bifurcation Parameters and Coronary Atherosclerosis. 评估视网膜动脉分叉参数与冠状动脉粥样硬化之间的相关性
IF 2.6 3区 医学 Q2 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-10-14 DOI: 10.1007/s40123-024-01038-2
Guangzheng Dai, Geng Wang, Sile Yu, Weinan Fu, Shenming Hu, Yue Huang, Xinze Luan, Xue Cao, Xiaoting Wang, Hairu Yan, Xinying Liu, Xingru He

Introduction: The aim of this study was to examine the relationship between the morphological parameters of retinal arteriolar bifurcations and coronary artery disease (CAD).

Methods: In this cross-sectional observational study, fundus photography was conducted on 444 participants to capture retinal arteriolar bifurcations. A total of 731 fundus photographs yielded 9625 measurable bifurcations. Analyzed bifurcation parameters included the diameters of the parent vessel (d0), the larger branch (d1), and the smaller branch (d2), as well as the angles (θ1) and (θ2) representing the orientation of each branch in relation to the parent vessel, respectively. Additionally, theoretical optimal angles ( θ 1 ' ) and ( θ 2 ' ), calculated from the measured parameters, provided a benchmark for ideal bifurcation geometry. The study assessed the variation in these parameters across different levels of coronary atherosclerosis severity.

Results: After adjusting for anatomical characteristics including the asymmetry ratio, area ratio, and distance to the optic disc, we observed that patients with severe coronary artery stenosis had significant deviations from the theoretical optimal bifurcation angles, with a decrease in ( θ 1 ' ) and an increase in ( θ 2 ' ) compared to those with moderate stenosis.

Conclusion: The findings suggest a clear alteration in retinal arteriolar bifurcation morphology among patients with severe CAD, which could potentially serve as an indicator of disease severity.

引言本研究旨在探讨视网膜动脉分叉的形态参数与冠状动脉疾病(CAD)之间的关系:在这项横断面观察研究中,对 444 名参与者进行了眼底摄影,以捕捉视网膜动脉分叉。共拍摄了 731 张眼底照片,获得了 9625 个可测量的分叉点。分析的分叉参数包括母血管(d0)、较大分支(d1)和较小分支(d2)的直径,以及分别代表各分支相对于母血管方向的角度(θ1)和(θ2)。此外,根据测量参数计算出的理论最佳角度(θ 1 ' )和(θ 2 ' )为理想的分叉几何形状提供了基准。研究评估了这些参数在不同冠状动脉粥样硬化严重程度下的变化:结果:在对解剖学特征(包括不对称比、面积比和到视盘的距离)进行调整后,我们观察到,与中度狭窄患者相比,重度冠状动脉狭窄患者的( θ 1 ')和( θ 2 ')明显偏离理论上的最佳分叉角度,( θ 1 ')减少,( θ 2 ')增加:结论:研究结果表明,重度 CAD 患者的视网膜动脉分叉形态发生了明显变化,有可能成为疾病严重程度的指标。
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引用次数: 0
What is Occluding Our Understanding of Retinal Vein Occlusion? 是什么阻碍了我们对视网膜静脉闭塞的理解?
IF 2.6 3区 医学 Q2 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-10-10 DOI: 10.1007/s40123-024-01042-6
Christiana Dinah, Andrew Chang, Junyeop Lee, William W Li, Rishi Singh, Lihteh Wu, David Wong, Insaf Saffar
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引用次数: 0
Micropulse Laser versus Eplerenone for Chronic Central Serous Chorioretinopathy: A 12-Month Comparison. 微脉冲激光与依普利酮治疗慢性中心性浆液性脉络膜视网膜病变:为期 12 个月的比较。
IF 2.6 3区 医学 Q2 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-10-26 DOI: 10.1007/s40123-024-01059-x
Pasquale Viggiano, Giacomo Boscia, Enrico Borrelli, Federica Evangelista, Ermete Giancipoli, Rodolfo Mastropasqua, Alberto Quarta, Maria Oliva Grassi, Raffaella Aloia, Giovanni Alessio, Lisa Toto, Francesco Boscia

Introduction: To compare the long-term efficacy of navigated subthreshold micropulse laser (NSML) and continuous oral eplerenone (EPL) in chronic central serous chorioretinopathy (cCSC).

Methods: This retrospective observational study included 44 eyes with cCSC (EPL: n = 26; NSML: n = 18). Best-corrected visual acuity (BCVA), central macular thickness (CMT), subretinal fluid (SRF) height, and subfoveal choroidal thickness (SFCT) were evaluated over 12 months.

Results: Both groups showed significant improvements in BCVA and CMT (p < 0.05). Complete SRF resolution was achieved in both groups by 12 months, with NSML showing faster resolution (2.77 ± 1.43 vs. 6.34 ± 2.17 months, p < 0.001). The EPL group demonstrated significant SFCT reduction at 6 and 12 months (p = 0.001), while the NSML group showed no significant SFCT changes (p > 0.05).

Conclusions: Both NSML and EPL improved retinal morphology and visual function in patients with cCSC. NSML achieved faster SRF resolution, while EPL resulted in more significant choroidal thickness reduction. These findings suggest distinct mechanisms of action: NSML primarily affects the retinal pigment epithelium, while EPL modulates choroidal vasculature. Treatment choice may depend on individual patient characteristics and treatment goals.

导言:比较导航阈下微脉冲激光(NSML)和连续口服依普利酮(EPL)对慢性中心性浆液性脉络膜视网膜病变(cCSC)的长期疗效:这项回顾性观察研究包括44只患有慢性中心性浆液性脉络膜视网膜病变的眼睛(EPL:n = 26;NSML:n = 18)。在 12 个月内对最佳矫正视力 (BCVA)、黄斑中心厚度 (CMT)、视网膜下积液 (SRF) 高度和眼底脉络膜厚度 (SFCT) 进行了评估:结果:两组患者的 BCVA 和 CMT 均有明显改善(P 0.05):结论:NSML和EPL都能改善cCSC患者的视网膜形态和视觉功能。结论:NSML 和 EPL 都能改善 cCSC 患者的视网膜形态和视觉功能,NSML 能更快地消除 SRF,而 EPL 则能更明显地减少脉络膜厚度。这些研究结果表明了它们不同的作用机制:NSML 主要影响视网膜色素上皮,而 EPL 则调节脉络膜血管。治疗选择可能取决于患者的个体特征和治疗目标。
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引用次数: 0
Intraretinal Microvascular Abnormalities in Eyes with Advanced Stages of Nonproliferative Diabetic Retinopathy: Comparison Between UWF-FFA, CFP, and OCTA-The RICHARD Study. 非增生性糖尿病视网膜病变晚期患者视网膜内微血管异常:UWF-FFA、CFP 和 OCTA 的比较--RICHARD 研究。
IF 2.6 3区 医学 Q2 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-10-26 DOI: 10.1007/s40123-024-01054-2
Ana R Santos, Marta Lopes, Torcato Santos, Débora Reste-Ferreira, Inês P Marques, Taffeta C N Yamaguchi, Telmo Miranda, Luís Mendes, António C V Martinho, Liz Pearce, José Cunha-Vaz

Introduction: This study aimed to evaluate intraretinal microvascular abnormalities (IRMA) in eyes with advanced nonproliferative diabetic retinopathy (NPDR) using multimodal approach in co-located areas focusing on central retina (up to 50°) and to look at possible correlations between IRMA and other structural changes, like ischemia and presence of microaneurysms.

Methods: The RICHARD study (NCT05112445) included 60 eyes from 60 patients with type 2 diabetes with moderate-severe NPDR, diabetic retinopathy severity levels 43, 47, and 53 (DRSS). IRMA were defined as capillary tortuosity covering a minimum circular area of 300 µm (calculated to correspond to the Early Treatment Diabetic Retinopathy Study standard photo 8A) and were identified using multimodal imaging with distinct fields of view (FoV): color fundus photography (CFP) using a Topcon TRC-50DX camera (Topcon Medical Systems, Japan), Optos California ultra wide field fundus fluorescein angiography (UWF-FFA) (Optos plc, UK), and swept-source optical coherence tomography angiography (SS-OCTA) (PLEX® Elite 9000, ZEISS, USA). Different areas of the retina were examined: central macula (up to 20°) and posterior pole (between 20° and 50°).

Results: Multimodal imaging was used to identify IRMA in co-located areas (FoV < 50°) including UWF-FFA, CFP, and SS-OCTA. In eyes with DRSS levels 47 and 53, IRMA were identified in both areas of the retina, while in eyes with DRSS level 43, IRMA were detected only outside of the central macula (FoV > 20°). Our results show that when evaluating the presence of IRMA (FoV < 50°), UWF-FFA detected 203 IRMA, SS-OCTA detected 133 IRMA, and CFP detected 104 IRMA. Our results also show that the presence of IRMA was positively associated with presence of microaneurysms.

Conclusions: Identification of IRMA in eyes with advanced NPDR is better achieved by UWF-FFA than CFP and SS-OCTA. A statistically significant correlation was found between the presence of IRMA and the increase in number of microaneurysms.

Trial registration: ClinicalTrials.gov, identifier NCT05112445.

简介本研究旨在使用多模态方法评估晚期非增殖性糖尿病视网膜病变(NPDR)患者视网膜内微血管异常(IRMA),重点是视网膜中央(50°以内),并研究IRMA与其他结构变化(如缺血和微动脉瘤的存在)之间可能存在的相关性:RICHARD研究(NCT05112445)纳入了60名2型糖尿病患者的60只眼睛,这些患者患有中重度NPDR,糖尿病视网膜病变严重程度为43、47和53级(DRSS)。IRMA定义为覆盖最小300微米圆形区域的毛细血管迂曲(计算方法与早期治疗糖尿病视网膜病变研究标准照片8A相对应),并通过具有不同视野(FoV)的多模态成像进行识别:使用拓普康 TRC-50DX 相机(日本拓普康医疗系统公司)进行彩色眼底照相(CFP)、Optos California 超宽视野眼底荧光素血管造影术(UWF-FFA)(英国 Optos plc 公司)和扫描源光学相干断层血管造影术(SS-OCTA)(PLEX® Elite 9000,美国蔡司公司)。检查视网膜的不同区域:黄斑中心(20°以内)和后极(20°至50°):结果:多模态成像用于识别共定位区域(视场角 20°)的 IRMA。我们的结果表明,在评估是否存在 IRMA 时(FoV 结论:与 CFP 和 SS-OCTA 相比,UWF-FFA 能更好地识别晚期 NPDR 患者的 IRMA。IRMA的存在与微动脉瘤数量的增加之间存在统计学意义上的相关性:试验注册:ClinicalTrials.gov,标识符 NCT05112445。
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引用次数: 0
Geometry of Modern Presbyopia-Correcting Intraocular Lenses and Changes in Haptic-Capsular Bag Behavior According to Compression and Different Well Diameters: A Bench Study Using Computed Tomography. 现代老花眼矫正眼内透镜的几何形状以及压迫和不同井径导致的触囊行为变化:使用计算机断层扫描的台架研究。
IF 2.6 3区 医学 Q2 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-10-09 DOI: 10.1007/s40123-024-01046-2
Andreas F Borkenstein, Eva-Maria Borkenstein

Introduction: The geometry of an intraocular lens (IOL), the design of the haptics, and the optic-haptic junction play a role in initial and long-term visual outcome after cataract surgery. Knowledge of the behavior of an implant in the capsular bag and under compression is of major importance. Our laboratory experiment analyzed in-depth the geometry of acrylic, single-piece, premium, presbyopia-correcting intraocular lenses and changes in haptic-capsular bag relationships according to capsular bag size using a range of compression well diameters.

Methods: One hydrophilic (RayOne Trifocal® RAO603F) and three hydrophobic intraocular lenses (AcrySof IQ PanOptix®, Synergy DFR00V™, and AT ELANA 841P®) were scanned with computed tomography (CT) in a dry, uncompressed state for quantitative analyses of haptic and optic-haptic junction (OHJ) dimensions and qualitative assessment of geometry. In the second part of the experiment, CT was performed after sample placement into a series of compression wells (9.0, 10.0, 11.0, 11.5 mm) for analyses of length of contact (LoC) between the haptics and the wells. Axial alignment and haptic-capsular bag relationships were assessed.

Results: The qualitative and quantitative evaluations highlighted differences in haptic and OHJ geometry and dimensions across the samples. The mid-zone of the optic was thickest in the hydrophilic sample (RayOne Trifocal® RAO603F) with a maximum of 0.880 mm compared to the thinnest hydrophobic sample (AT ELANA 841P®) with 0.564 mm. The AT ELANA 841P® showed the largest OHJ surface area (3.86 mm2) and OHJ volume (0.60 mm3) of the hydrophobic samples. The TECNIS Synergy DFR00V™ showed the thickest OHJ (0.51 mm), while the AcrySof IQ PanOptix® showed the thinnest OHJ (0.21 mm). The LoC values decreased with increasing well size for all tested samples. The AT ELANA 841P® showed the largest LoC and largest contact zones of hydrophobic samples in all wells.

Conclusion: The laboratory experiments highlight differences in the haptics, the OHJ geometric characteristics, and behavior of samples in different well diameters. The results support the idea that specific IOL designs may have advantages or disadvantages depending on anatomical dimensions. We cannot make any classification or rating (good versus bad) for clinical practice on the basis these experimental results, as many other factors play a role. However, knowledge of IOL geometry seems important to select the best option in each individual case.

导言:眼内人工晶体(IOL)的几何形状、触觉设计以及光学-触觉交界处对白内障手术后的初期和长期视觉效果都有影响。了解植入体在囊袋内和受压时的行为至关重要。我们的实验室实验深入分析了丙烯酸单片优质老花眼矫正眼内透镜的几何形状,以及在一系列压缩井直径下,根据囊袋大小而发生的触觉与囊袋关系的变化:方法:使用计算机断层扫描(CT)对一种亲水性镜片(RayOne Trifocal® RAO603F)和三种疏水性眼内镜片(AcrySof IQ PanOptix®、Synergy DFR00V™ 和 AT ELANA 841P®)在干燥、未压缩状态下的触觉和视触交界处(OHJ)尺寸进行定量分析,并对几何形状进行定性评估。在实验的第二部分,将样品放入一系列压缩井(9.0、10.0、11.0、11.5 毫米)后进行 CT 扫描,以分析触觉和压缩井之间的接触长度(LoC)。结果:定性和定量评估突出显示了不同样品在触觉和光学视网膜几何形状和尺寸上的差异。亲水性样品(RayOne Trifocal® RAO603F)的光学中间区最厚,最大为 0.880 毫米,而疏水性样品(AT ELANA 841P®)最薄,为 0.564 毫米。在疏水性样品中,AT ELANA 841P® 的 OHJ 表面积(3.86 平方毫米)和 OHJ 体积(0.60 立方毫米)最大。TECNIS Synergy DFR00V™ 的 OHJ 最厚(0.51 毫米),而 AcrySof IQ PanOptix® 的 OHJ 最薄(0.21 毫米)。所有测试样品的 LoC 值都随着孔径的增大而降低。AT ELANA 841P® 在所有井中都显示出最大的 LoC 值和最大的疏水性样品接触区:实验室实验凸显了不同孔径样品在触感、OHJ 几何特性和行为上的差异。实验结果支持了这样一种观点,即特定的人工晶体设计可能因解剖尺寸的不同而具有优势或劣势。我们不能根据这些实验结果对临床实践进行任何分类或评级(好与坏),因为还有许多其他因素在起作用。不过,了解人工晶体的几何形状对于在每个病例中选择最佳方案似乎很重要。
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引用次数: 0
Impact of Aflibercept vs Dexamethasone Treatment on Epiretinal Membrane Formation in Eyes with Diabetic Macular Edema. 阿弗利百普与地塞米松治疗对糖尿病黄斑水肿患者视网膜外膜形成的影响
IF 2.6 3区 医学 Q2 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-10-25 DOI: 10.1007/s40123-024-01057-z
Hsin-Ho Chang, Sheng-Chu Chi, Shih-Jen Chen, Yu-Bai Chou, Tai-Chi Lin

Introduction: This study aimed to investigate the impact of aflibercept and dexamethasone (DEX) on the formation of epiretinal membrane (ERM) and their treatment outcomes in eyes with diabetic macular edema (DME).

Methods: In this retrospective cohort study, medical records of 124 eyes from 429 patients diagnosed with DME were reviewed between June 2017 and June 2019. Patients were categorized into two groups: the aflibercept group (67 eyes) and the DEX group (57 eyes). The primary endpoint was the secondary ERM incidence following intravitreal treatments and its correlation across different medications. Secondary endpoints included longitudinal changes in best-corrected visual acuity (BCVA) and central macular thickness (CMT).

Results: Over a 24-month follow-up, eyes treated with DEX had approximately a fourfold higher incidence of ERM development compared to aflibercept [hazard ratio (HR) = 3.97, p = 0.02]. These eyes also showed worse BCVA (p = 0.059) and increased CMT (p = 0.004), despite requiring fewer total injections (p = 0.000) in the survival analysis model. The cumulative probability of ERM formation was 13.7%. Additionally, DME eyes exhibited poor functional and anatomical outcomes after developing ERM, while age, A1c level, DR severity, initial BCVA and CMT, lens status, and previous laser treatment were not associated with an elevated incidence of ERM formation.

Conclusion: Intravitreal DEX implantation in DME eyes resulted in a higher incidence of secondary ERM formation compared to aflibercept over a 2-year period. The therapeutic efficacy for DME was diminished following ERM development, leading to worse anatomical outcomes. New therapeutic approaches should be explored to prevent ERM formation while maintaining both anatomical and functional outcomes in DME treatment.

简介本研究旨在探讨阿弗利百普(aflibercept)和地塞米松(DEX)对糖尿病性黄斑水肿(DME)患者视网膜外膜(ERM)形成的影响及其治疗效果:在这项回顾性队列研究中,对2017年6月至2019年6月期间确诊为DME的429名患者的124只眼睛的病历进行了回顾。患者分为两组:aflibercept组(67眼)和DEX组(57眼)。主要终点是玻璃体内治疗后的继发性 ERM 发生率及其与不同药物的相关性。次要终点包括最佳矫正视力(BCVA)和黄斑中心厚度(CMT)的纵向变化:在24个月的随访中,与阿弗利贝赛相比,接受DEX治疗的眼睛发生ERM的几率高出约4倍[危险比(HR)=3.97,P=0.02]。在生存分析模型中,尽管需要的总注射次数较少(p = 0.000),但这些眼睛的BCVA(p = 0.059)和CMT(p = 0.004)也较差。ERM 形成的累积概率为 13.7%。此外,DME 眼球在发生 ERM 后,功能和解剖结果都很差,而年龄、A1c 水平、DR 严重程度、初始 BCVA 和 CMT、晶状体状态和既往激光治疗与 ERM 形成的高发生率无关:结论:与阿弗利贝赛相比,在DME眼球内植入DEX会在两年内导致更高的继发性ERM形成率。ERM形成后,对DME的疗效会减弱,导致更差的解剖结果。应探索新的治疗方法,以防止 ERM 的形成,同时保持 DME 治疗的解剖和功能效果。
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引用次数: 0
Clinical Evaluation of Violet Light Filtration and High-Resolution Lathing on a Diffractive Extended Depth of Focus IOL. 衍射型延展焦深人工晶体的紫光过滤和高分辨率缝合临床评估
IF 2.6 3区 医学 Q2 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-10-25 DOI: 10.1007/s40123-024-01056-0
Daniel H Chang, Andrew A Kao, Laura K Huggins, Jacqueline N Albert, Jacqueline N Whinery, Brittany M Camirand

Introduction: This study is a prospective, randomized, subject/evaluator-masked clinical trial in a single-center clinical setting. The purpose of the study is to compare the clinical performance of Tecnis Symfony Optiblue IOL (models ZXR00V and ZXW150) with violet light filter (VLF) and manufacturing improvements versus Tecnis Symfony IOL (models ZXR00 and ZXT150) with ultraviolet light filter (UVF) in patients undergoing cataract surgery.

Methods: Patients with cataracts aged ≥ 22 years were randomly assigned 1:1 to bilateral implantation with ZXR00V/ZXW150 (VLF group) or ZXR00/ZXT150 (UVF group). Key endpoints at 6 months postoperative included patient reported nighttime dysphotopsia symptoms, 25% low contrast visual acuity with glare, and patient satisfaction.

Results: Sixty patients were implanted with ZXR00V/ZXW150 (30) or ZXR00/ZXT150 (30). At 6 months, the VLF group did not show a statistically significant differences in mean monocular photopic uncorrected distance visual acuity (UCDVA), best-corrected distance visual acuity (BCDVA), uncorrected near visual acuity (UCNVA) (40 cm), or distance-corrected near visual acuity (DCNVA) (40 cm) compared to the UVF group. At 1 month, patients in the VLF group reported significantly less difficulty due to halo (p = 0.016) and starburst (p = 0.028) symptoms. By the 6 months, dysphotopsia complaints were no longer significantly different between the groups. Although the VLF group trended toward better low contrast visual acuity and patient satisfaction, statistical significance was not reached.

Conclusions: Managing the patients' expectations is key to achieving success. At the 1-month visit the patients who reported dysphotopsia complaints in the VLF group had significantly less difficulty with starbursts and halos as compared to the UVF group. By the 6-month visit, there was no significant difference between the two groups in the difficulty with starbursts and halos.

Trial registration: ClinicalTrials.gov identifier, NCT06567834.

研究简介本研究是一项在单中心临床环境下进行的前瞻性、随机、受试者/评估者屏蔽临床试验。研究目的是在白内障手术患者中比较带紫光过滤器(VLF)和制造改进的 Tecnis Symfony Optiblue IOL(型号 ZXR00V 和 ZXW150)与带紫外线过滤器(UVF)的 Tecnis Symfony IOL(型号 ZXR00 和 ZXT150)的临床表现:年龄≥ 22 岁的白内障患者按 1:1 随机分配到双侧植入 ZXR00V/ZXW150 (VLF 组)或 ZXR00/ZXT150 (UVF 组)。术后 6 个月的关键终点包括患者报告的夜间视力障碍症状、25% 的低对比度眩光视力和患者满意度:60名患者植入了ZXR00V/ZXW150(30人)或ZXR00/ZXT150(30人)。6 个月时,与 UVF 组相比,VLF 组的平均单眼光视未校正远视力 (UCDVA)、最佳校正远视力 (BCDVA)、未校正近视力 (UCNVA) (40 厘米) 或远视力校正近视力 (DCNVA) (40 厘米) 均无显著统计学差异。1 个月时,VLF 组患者报告的光晕(p = 0.016)和星辉(p = 0.028)症状明显减少。6 个月后,两组患者的视力障碍症状不再有明显差异。虽然 VLF 组的低对比度视力和患者满意度呈上升趋势,但未达到统计学意义:管理好患者的期望值是取得成功的关键。在 1 个月的就诊中,VLF 组报告视力障碍的患者与 UVF 组相比,在星芒和光晕方面的困难明显减少。在 6 个月的检查中,两组患者在星芒和光晕方面没有明显差异:试验注册:ClinicalTrials.gov identifier,NCT06567834。
{"title":"Clinical Evaluation of Violet Light Filtration and High-Resolution Lathing on a Diffractive Extended Depth of Focus IOL.","authors":"Daniel H Chang, Andrew A Kao, Laura K Huggins, Jacqueline N Albert, Jacqueline N Whinery, Brittany M Camirand","doi":"10.1007/s40123-024-01056-0","DOIUrl":"10.1007/s40123-024-01056-0","url":null,"abstract":"<p><strong>Introduction: </strong>This study is a prospective, randomized, subject/evaluator-masked clinical trial in a single-center clinical setting. The purpose of the study is to compare the clinical performance of Tecnis Symfony Optiblue IOL (models ZXR00V and ZXW150) with violet light filter (VLF) and manufacturing improvements versus Tecnis Symfony IOL (models ZXR00 and ZXT150) with ultraviolet light filter (UVF) in patients undergoing cataract surgery.</p><p><strong>Methods: </strong>Patients with cataracts aged ≥ 22 years were randomly assigned 1:1 to bilateral implantation with ZXR00V/ZXW150 (VLF group) or ZXR00/ZXT150 (UVF group). Key endpoints at 6 months postoperative included patient reported nighttime dysphotopsia symptoms, 25% low contrast visual acuity with glare, and patient satisfaction.</p><p><strong>Results: </strong>Sixty patients were implanted with ZXR00V/ZXW150 (30) or ZXR00/ZXT150 (30). At 6 months, the VLF group did not show a statistically significant differences in mean monocular photopic uncorrected distance visual acuity (UCDVA), best-corrected distance visual acuity (BCDVA), uncorrected near visual acuity (UCNVA) (40 cm), or distance-corrected near visual acuity (DCNVA) (40 cm) compared to the UVF group. At 1 month, patients in the VLF group reported significantly less difficulty due to halo (p = 0.016) and starburst (p = 0.028) symptoms. By the 6 months, dysphotopsia complaints were no longer significantly different between the groups. Although the VLF group trended toward better low contrast visual acuity and patient satisfaction, statistical significance was not reached.</p><p><strong>Conclusions: </strong>Managing the patients' expectations is key to achieving success. At the 1-month visit the patients who reported dysphotopsia complaints in the VLF group had significantly less difficulty with starbursts and halos as compared to the UVF group. By the 6-month visit, there was no significant difference between the two groups in the difficulty with starbursts and halos.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier, NCT06567834.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"3135-3147"},"PeriodicalIF":2.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Preservative-Free Combination of Sodium Hyaluronate and Trehalose Improves Dry Eye Signs and Symptoms and Increases Patient Satisfaction in Real-Life Settings: The TEARS Study. 不含防腐剂的透明质酸钠和曲哈洛糖复方制剂可改善干眼症症状,提高患者在实际生活中的满意度:TEARS研究。
IF 2.6 3区 医学 Q2 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-10-21 DOI: 10.1007/s40123-024-01044-4
Antonio J Mateo-Orobia, Sarah Farrant, Eduardo Del-Prado-Sanz, Alejandro Blasco-Martínez, Miriam Idoipe-Corta, Noelia Lafuente-Ojeda, Luis E Pablo-Júlvez

Introduction: Dry eye disease (DED) is a frequently observed condition characterized by ocular discomfort and visual disturbance. It is highly prevalent and impairs patients' quality of life (QoL). This study assessed the benefit of a preservative-free bioprotectant eye drop formulation containing sodium hyaluronate and trehalose (SH-trehalose) with regards to DED, as well as patient satisfaction, through a large-scale real-life survey.

Methods: In a multi-center, international, prospective observational study, subjects with DED received SH-trehalose for 84 days. Ocular Surface Disease Index (OSDI), Dry Eye Questionnaire-5 items (DEQ-5), and patient satisfaction were assessed at baseline, day 28, and day 84, and clinical evaluations included ocular surface staining, Schirmer test, tear film break-up time (TBUT), and conjunctival hyperemia at baseline and day 84.

Results: A total of 312 patients were evaluated, of whom 82.4% were women. The mean age was 57.9 ± 15.2 years. The mean OSDI score at baseline was 41.7 ± 20.6. After 84 days, the mean OSDI score was 27.3 ± 19.8 (p < 0.001). The percentage of patients with a severe OSDI score decreased from 60.3 to 34.5%. The DEQ-5 score significantly (p < 0.001) improved after 28 and 84 days, as did patient satisfaction. Ocular surface staining, Schirmer test, TBUT, and conjunctival hyperemia scores improved significantly (all p < 0.001) for both eyes with SH-trehalose between baseline and day 84. Tolerance of SH-trehalose was good.

Conclusions: SH-trehalose significantly improved the clinical signs and symptoms of DED after 84 days. Moreover, it significantly increased patient satisfaction and was well tolerated.

Trial registration: NCT04803240.

简介干眼症(DED)是一种常见病,以眼部不适和视力障碍为特征。干眼症发病率很高,会损害患者的生活质量(QoL)。本研究通过一项大规模的实际调查,评估了不含防腐剂的生物保护剂滴眼液配方(含透明质酸钠和曲哈洛糖,SH-曲哈洛糖)对干眼症的益处以及患者的满意度:在一项多中心、国际性、前瞻性观察研究中,患有 DED 的受试者接受了为期 84 天的 SH-曲哈洛糖治疗。在基线、第 28 天和第 84 天评估眼表疾病指数 (OSDI)、干眼症问卷-5 项目 (DEQ-5) 和患者满意度,临床评估包括基线和第 84 天的眼表染色、Schirmer 试验、泪膜破裂时间 (TBUT) 和结膜充血:共对 312 名患者进行了评估,其中 82.4% 为女性。平均年龄为 57.9±15.2 岁。基线时的平均 OSDI 得分为 41.7 ± 20.6。84 天后,OSDI 平均得分为(27.3 ± 19.8)(P 结论:SH-曲哈洛糖显著改善了患者的心肌梗死症状:84 天后,SH-曲哈洛糖明显改善了 DED 的临床症状和体征。此外,它还能明显提高患者的满意度,且耐受性良好:试验注册:NCT04803240。
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引用次数: 0
A Response to: Letter to the Editor regarding "Efficacy of Multifocal Soft Contact Lenses in Reducing Myopia Progression Among Taiwanese Schoolchildren: A Randomized Paired-Eye Clinical Trial". 回应:致编辑的信,内容涉及 "多焦点软性隐形眼镜在降低台湾学童近视度数加深方面的功效:随机配对眼临床试验 "的编辑来信。
IF 2.6 3区 医学 Q2 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-10-21 DOI: 10.1007/s40123-024-01047-1
Yao-Lin Liu, Tzu-Hsun Tsai
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引用次数: 0
期刊
Ophthalmology and Therapy
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