Pub Date : 2023-12-20DOI: 10.1080/2162402x.2023.2290787
Chia-Chi Lin, Elena Garralda, P. Schöffski, David S. Hong, L.L. Siu, Miguel Martin, Michela Maur, Rina Hui, Ross A Soo, Joanne Chiu, Tian Zhang, B. Ma, C. Kyi, Daniel SW Tan, P. Cassier, J. Sarantopoulos, A.J. Weickhardt, Richard D. Carvajal, Jennifer Spratlin, T. Esaki, F. Rolland, Wallace Akerley, B. Deschler-Baier, L. Rispoli, T. Samant, Niladri Roy Chowdhury, D. Gusenleitner, Eunice L. Kwak, V. Askoxylakis, Filippo G. de Braud
{"title":"A phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies","authors":"Chia-Chi Lin, Elena Garralda, P. Schöffski, David S. Hong, L.L. Siu, Miguel Martin, Michela Maur, Rina Hui, Ross A Soo, Joanne Chiu, Tian Zhang, B. Ma, C. Kyi, Daniel SW Tan, P. Cassier, J. Sarantopoulos, A.J. Weickhardt, Richard D. Carvajal, Jennifer Spratlin, T. Esaki, F. Rolland, Wallace Akerley, B. Deschler-Baier, L. Rispoli, T. Samant, Niladri Roy Chowdhury, D. Gusenleitner, Eunice L. Kwak, V. Askoxylakis, Filippo G. de Braud","doi":"10.1080/2162402x.2023.2290787","DOIUrl":"https://doi.org/10.1080/2162402x.2023.2290787","url":null,"abstract":"","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"50 2","pages":""},"PeriodicalIF":7.2,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138954587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-18DOI: 10.1080/2162402x.2023.2294564
Alvaro López Malizia, Antonela Merlotti, Pierre-Emmanuel Bonte, Melina Sager, Yago Arribas De Sandoval, Christel Goudot, Fernando Erra Díaz, Pehuén Pereyra-Gerber, Ana Ceballos, Sebastian Amigorena, Jorge Geffner, Juan Sabatte
Dendritic cells (DCs) play a key role in the induction of the adaptive immune response. They capture antigens in peripheral tissues and prime naïve T lymphocytes, triggering the adaptive immune res...
树突状细胞（DC）在诱导适应性免疫反应中起着关键作用。它们捕获外周组织中的抗原，为幼稚的 T 淋巴细胞提供能量，从而触发适应性免疫反应。
{"title":"Clusterin protects mature dendritic cells from reactive oxygen species mediated cell death","authors":"Alvaro López Malizia, Antonela Merlotti, Pierre-Emmanuel Bonte, Melina Sager, Yago Arribas De Sandoval, Christel Goudot, Fernando Erra Díaz, Pehuén Pereyra-Gerber, Ana Ceballos, Sebastian Amigorena, Jorge Geffner, Juan Sabatte","doi":"10.1080/2162402x.2023.2294564","DOIUrl":"https://doi.org/10.1080/2162402x.2023.2294564","url":null,"abstract":"Dendritic cells (DCs) play a key role in the induction of the adaptive immune response. They capture antigens in peripheral tissues and prime naïve T lymphocytes, triggering the adaptive immune res...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"5 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138745973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anti-PD-1 antibody therapy has achieved success in tumor treatment; however, the duration of its clinical benefits are typically short. The functional state of intratumoral CD8+ T cells substantial...
{"title":"LFA-1 regulated by IL-2/STAT5 pathway boosts antitumor function of intratumoral CD8+ T cells for improving anti-PD-1 antibody therapy","authors":"Jiqi Shan, Wei Jing, Yu Ping, Chunyi Shen, Dong Han, Fengsen Liu, Yaqing Liu, Congcong Li, Yi Zhang","doi":"10.1080/2162402x.2023.2293511","DOIUrl":"https://doi.org/10.1080/2162402x.2023.2293511","url":null,"abstract":"Anti-PD-1 antibody therapy has achieved success in tumor treatment; however, the duration of its clinical benefits are typically short. The functional state of intratumoral CD8+ T cells substantial...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"68 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138627828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-10DOI: 10.1080/2162402x.2023.2290799
Thomas V. Guy, Alexandra M. Terry, Helen M. McGuire, Elena Shklovskaya, Barbara Fazekas de St Groth
There has been growing interest in the role of B cells in antitumour immunity and potential use in adoptive cellular therapies. To date, the success of such therapies is limited. The intrinsic capa...
人们越来越关注 B 细胞在抗肿瘤免疫中的作用以及在采纳性细胞疗法中的潜在用途。迄今为止，这种疗法的成功率有限。B细胞的固有能力和免疫功能是导致这种疗法失败的主要原因。
{"title":"MHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4+ T cells in vivo","authors":"Thomas V. Guy, Alexandra M. Terry, Helen M. McGuire, Elena Shklovskaya, Barbara Fazekas de St Groth","doi":"10.1080/2162402x.2023.2290799","DOIUrl":"https://doi.org/10.1080/2162402x.2023.2290799","url":null,"abstract":"There has been growing interest in the role of B cells in antitumour immunity and potential use in adoptive cellular therapies. To date, the success of such therapies is limited. The intrinsic capa...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"3 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138568746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Immunotherapy has shown intracranial efficacy in non-small cell lung cancer (NSCLC) patients with brain metastases. However, predictive biomarkers for intracranial response to immunotherapy are lac...
{"title":"Cerebrospinal fluid immunological cytokines predict intracranial tumor response to immunotherapy in non-small cell lung cancer patients with brain metastases","authors":"Meichen Li, Jing Chen, Hui Yu, Baishen Zhang, Xue Hou, Honghua Jiang, Dan Xie, Likun Chen","doi":"10.1080/2162402x.2023.2290790","DOIUrl":"https://doi.org/10.1080/2162402x.2023.2290790","url":null,"abstract":"Immunotherapy has shown intracranial efficacy in non-small cell lung cancer (NSCLC) patients with brain metastases. However, predictive biomarkers for intracranial response to immunotherapy are lac...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"30 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138545588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-07DOI: 10.1080/2162402x.2023.2290900
Morten Nielsen, Tine Monberg, Vibeke Sundvold, Benedetta Albieri, Dorrit Hovgaard, Michael Mørk Petersen, Anders Krarup-Hansen, Özcan Met, Ketil Camilio, Trevor Clancy, Richard Stratford, Baldur Sveinbjornsson, Øystein Rekdal, Niels Junker, Inge Marie Svane
LTX-315 is an oncolytic peptide that elicits both local and systemic immune responses upon intratumoral injection. In the present pilot trial, we treated patients with metastatic soft tissue sarcom...
{"title":"LTX-315 and adoptive cell therapy using tumor-infiltrating lymphocytes generate tumor specific T cells in patients with metastatic soft tissue sarcoma","authors":"Morten Nielsen, Tine Monberg, Vibeke Sundvold, Benedetta Albieri, Dorrit Hovgaard, Michael Mørk Petersen, Anders Krarup-Hansen, Özcan Met, Ketil Camilio, Trevor Clancy, Richard Stratford, Baldur Sveinbjornsson, Øystein Rekdal, Niels Junker, Inge Marie Svane","doi":"10.1080/2162402x.2023.2290900","DOIUrl":"https://doi.org/10.1080/2162402x.2023.2290900","url":null,"abstract":"LTX-315 is an oncolytic peptide that elicits both local and systemic immune responses upon intratumoral injection. In the present pilot trial, we treated patients with metastatic soft tissue sarcom...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"37 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138568750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.1080/2162402x.2023.2289738
Mengjia Song, Yue Huang, Ye Hong, Juan Liu, Jia Zhu, Suying Lu, Juan Wang, Feifei Sun, Junting Huang, Jiaqian Xu, Yan Tang, Jian-Chuan Xia, Yizhuo Zhang
T/NK cell-based immunotherapy has achieved remarkable success in adult cancers but has limited efficacy in pediatric malignancies including high-risk neuroblastoma (NB). Immune defects of NB tumor ...
{"title":"PD-L1-expressing natural killer cells predict favorable prognosis and response to PD-1/PD-L1 blockade in neuroblastoma","authors":"Mengjia Song, Yue Huang, Ye Hong, Juan Liu, Jia Zhu, Suying Lu, Juan Wang, Feifei Sun, Junting Huang, Jiaqian Xu, Yan Tang, Jian-Chuan Xia, Yizhuo Zhang","doi":"10.1080/2162402x.2023.2289738","DOIUrl":"https://doi.org/10.1080/2162402x.2023.2289738","url":null,"abstract":"T/NK cell-based immunotherapy has achieved remarkable success in adult cancers but has limited efficacy in pediatric malignancies including high-risk neuroblastoma (NB). Immune defects of NB tumor ...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"66 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138516195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Although immune-based therapies have revolutionized the management of cancer, novel approaches are urgently needed to improve their outcome. We investigated the role of endogenous steroids in the r...
{"title":"Activation of endogenous glucocorticoids by HSD11B1 inhibits the antitumor immune response in renal cancer","authors":"Hélène Poinot, Eloïse Dupuychaffray, Grégoire Arnoux, Montserrat Alvarez, Jérémie Tachet, Ounss Ezzar, Jonathan Moore, Olivia Bejuy, Eulalia Olesti, Gioele Visconti, Víctor González-Ruiz, Serge Rudaz, Jean-Christophe Tille, Clarissa D. Voegel, Patrycja Nowak-Sliwinska, Carole Bourquin, Aurélien Pommier","doi":"10.1080/2162402x.2023.2286820","DOIUrl":"https://doi.org/10.1080/2162402x.2023.2286820","url":null,"abstract":"Although immune-based therapies have revolutionized the management of cancer, novel approaches are urgently needed to improve their outcome. We investigated the role of endogenous steroids in the r...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"19 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138516202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-27DOI: 10.1080/2162402x.2023.2284483
Juliane Blümke, Marcus Bauer, Christoforos Vaxevanis, Andreas Wilfer, Ofer Mandelboim, Claudia Wickenhauser, Barbara Seliger, Simon Jasinski-Bergner
The human Epstein–Barr virus (EBV), as a member of the human γ herpes viruses (HHV), is known to be linked with distinct tumor types. It is a double-stranded DNA virus and its genome encodes among ...
{"title":"Identification and characterization of the anti-viral interferon lambda 3 as direct target of the Epstein-Barr virus microRNA-BART7-3p","authors":"Juliane Blümke, Marcus Bauer, Christoforos Vaxevanis, Andreas Wilfer, Ofer Mandelboim, Claudia Wickenhauser, Barbara Seliger, Simon Jasinski-Bergner","doi":"10.1080/2162402x.2023.2284483","DOIUrl":"https://doi.org/10.1080/2162402x.2023.2284483","url":null,"abstract":"The human Epstein–Barr virus (EBV), as a member of the human γ herpes viruses (HHV), is known to be linked with distinct tumor types. It is a double-stranded DNA virus and its genome encodes among ...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"7 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138516198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esophageal squamous cell carcinoma (ESCC) is a prevalent malignant tumor of the digestive tract with a low 5-year survival rate due to the lack of effective treatment methods. Although therapeutic ...
{"title":"A novel Fc-enhanced humanized monoclonal antibody targeting B7-H3 suppresses the growth of ESCC","authors":"Huiting Wu, Chang Liu, Qiang Yuan, Yan Qiao, Yongwei Ding, Lina Duan, Wenjing Li, Mengjia Zhang, Xuhua Zhang, Yanan Jiang, Jing Lu, Ziming Dong, Tao Wang, Kangdong Liu, Jimin Zhao","doi":"10.1080/2162402x.2023.2282250","DOIUrl":"https://doi.org/10.1080/2162402x.2023.2282250","url":null,"abstract":"Esophageal squamous cell carcinoma (ESCC) is a prevalent malignant tumor of the digestive tract with a low 5-year survival rate due to the lack of effective treatment methods. Although therapeutic ...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"24 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138516224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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