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Mechanical Properties of Mineralized Collagen Type I Rat-Tail Tendon Fascicles 矿化胶原I型大鼠尾腱束的力学特性
Pub Date : 2022-09-18 DOI: 10.24018/ejdent.2022.3.4.160
Jeromi G. López-Santiago, P. Sundaram
Type I collagen fibers transmit forces, dissipate energy, and prevent mechanical failure in normal tissues. Mineralization of collagen fibers is proposed to strengthen these structural proteins as a possible therapeutic option for small tears in soft tissues such as cemental tears in periodontal ligaments.  In the present study, collagen fascicles extracted from the tail tendons of male Sprague-Dawley rats were tested in a MiniMat tensile tester at different strain rates. The fascicles were previously immersed in SBF to induce mineralization and were maintained in a moist condition during mechanical testing. Mineralization of the fascicles resulted in an increase in the modulus of elasticity and tensile strength with minimal change in percentage elongation to failure. From SEM/EDS, calcium phosphate deposits formed on the fascicles indicating a high probability of intrafibrillar mineralization resulting in the observed improvement in mechanical properties.
I型胶原纤维在正常组织中传递力,耗散能量,防止机械失效。胶原纤维矿化可以强化这些结构蛋白,作为治疗软组织小撕裂的一种可能选择,如牙周韧带的骨水泥撕裂。本研究从雄性sd大鼠尾肌腱中提取胶原束,在MiniMat拉伸仪上对不同应变速率下的胶原束进行了测试。将神经束浸入SBF中诱导矿化,并在力学试验中保持湿润状态。肌束的矿化导致弹性模量和抗拉强度的增加,而断裂伸长率的变化很小。扫描电镜/能谱分析显示,在纤维束上形成了磷酸钙沉积物,这表明纤维束内矿化的可能性很大,从而导致了观察到的力学性能的改善。
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引用次数: 1
Myoepithelioma of Minor Salivary Gland: A Case Report 小唾液腺肌上皮瘤1例报告
Pub Date : 2022-09-18 DOI: 10.24018/ejdent.2022.3.4.131
A. Barbosa, Álvaro Rodrigues, Teresa Corrales, Sónia Viegas
Introduction: The myoepithelioma is a rare form of salivary glands tumors. The conservative surgery is the treatment of choice.Case Report: 49 years old male with a submucosa mass of the inferior lip with over 20 years of evolution without progressive growth, bleeding or pain. The patient had no risk factors except history of smoking (34 pack-years). At physical examination the patient presented a consistent submucosa mass of the inferior lip at the right, mobile, painless and without visual signs of abnormal mucosa over the mass. An excisional biopsy was performed and the piece had a reniform shape and rubberish consistency with 30 x16 mm dimension. The histology exam revealed a myoepithelioma of minor salivary gland.Discussion: Tumors with an exclusive constitution of myoepithelial cells are rare. The majority is located at parotid gland. Conclusion: Myoepithelioma of minor salivary glands are rare and the number of reported cases is limited. The differential diagnosis with pleomorphic adenoma is important.
肌上皮瘤是一种罕见的唾液腺肿瘤。保守手术是治疗的首选。病例报告:49岁男性,下唇黏膜下肿物,发展超过20年,无进行性生长,出血或疼痛。除有吸烟史(34包年)外,无其他危险因素。体格检查时,患者表现为右侧下唇粘膜下层肿块,可活动,无痛,肿块上方无明显异常粘膜征象。行切除活检,切片呈肾状,尺寸为30 × 16 mm,具有橡胶状一致性。组织学检查显示为小唾液腺肌上皮瘤。讨论:仅由肌上皮细胞构成的肿瘤是罕见的。多数位于腮腺。结论:小唾液腺肌上皮瘤罕见,报告病例有限。多形性腺瘤的鉴别诊断很重要。
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引用次数: 0
Oral Lipoma: A Case Report 口腔脂肪瘤1例报告
Pub Date : 2022-09-05 DOI: 10.24018/ejdent.2022.3.4.201
Montserrat Escuadra-Landeros, César Esquivel-Chirino, Yolanda Valero Princet, Daniela Carmona-RuÍz
Lipomas are the most frequent benign neoplasms of mesenchymal origin, and they mostly occur in various anatomical sites, including the palate, lip, buccal mucosa and vestibule, tongue, and floor of the mouth. Lipomas have a low incidence between 1 to 4% of benign oral cavity lesions. The clinical presentation of lipomas is generally characterized as a neoformation with well-demarcated borders. In this clinical case report, a 66-year-old female patient presented with pain and an inflamed region in the oral cavity. In intraoral clinical examination, a neoformation of 1 centimeter in diameter was observed and located in the jugal mucosa of the right side of the oral cavity. Furthermore, an excisional biopsy was chosen as the treatment method, and a postoperative histopathological study was conducted. Surgical excision is the treatment of choice for preventing recurrence in patients with oral lipomas.
脂肪瘤是最常见的间质良性肿瘤,多发生于不同解剖部位,包括腭、唇、颊粘膜、前庭、舌和口腔底。脂肪瘤在口腔良性病变中的发病率很低,在1%到4%之间。脂肪瘤的临床表现通常表现为边界清晰的新生肿瘤。在这个临床病例报告中,一位66岁的女性患者表现为口腔疼痛和炎症区域。在口腔内临床检查中,发现一直径1厘米的新生物,位于口腔右侧的痔粘膜。此外,选择切除活检作为治疗方法,并进行术后组织病理学研究。手术切除是预防口腔脂肪瘤复发的首选治疗方法。
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引用次数: 0
Techniques and Graft Materials Used in Maxillary Sinus Lift Procedure for Dental Implant Placement 上颌窦提升术用于种植体植入的技术和移植物材料
Pub Date : 2022-08-31 DOI: 10.24018/ejdent.2022.3.4.198
Noor Mohammed Al-Noori, Fatima Ali Makawi
Posterior quadrant of the maxilla consider as special challenges for use of implant active prostheses to restore dental function. Placement of Implant in the posterior part of maxilla influence hesitation due to the lack of sufficient alveolar bone height. This occurs due to the proximity of alveolar crest to the maxillary sinus because of sinus pneumatization, along with resorption of bone of the alveolar ridge secondary to tooth extraction, pathological lesion or trauma. Sinus lifting to augment atrophic maxillary posterior area to create space for implantation has been progressively widespread in latest years. In literatures 2 approaches have been designated for sinus lifting: the direct approach called also lateral approach and the indirect approach called also crestal approach.
上颌后象限被认为是使用种植主动修复体恢复牙功能的特殊挑战。由于牙槽骨高度不足,种植体放置在上颌骨后部会影响犹豫。发生这种情况的原因是由于鼻窦气化导致牙槽嵴靠近上颌窦,以及拔牙、病理病变或外伤引起的牙槽嵴骨吸收。近年来,窦提升术逐渐广泛应用于增加萎缩的上颌后区,为种植创造空间。在文献中,有两种入路被指定用于窦抬高:直接入路也称为外侧入路,间接入路也称为嵴入路。
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引用次数: 0
Oral Lichen Planus Genetics Update 口腔扁平苔藓遗传学进展
Pub Date : 2022-08-29 DOI: 10.24018/ejdent.2022.3.4.205
C. Albu, Maria-Angelica Bencze, A. Dragomirescu, C. Vlădan, Ș. Albu, Emily-Alice Russu, E. Ionescu
Lichen planus is a chronic autoimmune multi-factorial inflammatory condition of the mucocutaneous skin that mainly interests the skin and oral mucosa. Oral Lichen Planus (OLP) affects 0.5 to 1% of the world's population and all human races equally. The factors that act as triggers of autoimmune processes and determine the appearance of OLP are represented by genetic predisposition, skin injuries, viral infections, contact allergies, and medications. OLP affects the oral mucosa and occurs frequently on the inside of the cheeks and less often on the edges of the tongue, gums, or lips. The condition is manifested by the appearance of painful erosions and mouth ulcers, accompanied by erythema and gingival scaling, and sometimes localized inflammation of the gums, near the amalgam fillings. There are 132 genes currently involved in the etiopathogenesis of OLP, but only a few appear to play a major role. These genes have been termed "leader genes". Thus, based on bioinformatics studies, the main genes involved in the pathogenesis of OPL are JUN, EGFR, FOS, IL2, and ITGB4.  Although genetic status, immune system background, and infectious diseases are considered to be the most important incriminating and determining factors, the etiopathogenesis of OLP remains poorly known. Further genetic research is needed in order to achieve the generalizability of the findings and to strengthen the obtaining results.
扁平苔藓是一种以皮肤和口腔粘膜为主的慢性自身免疫性多因素炎症。口腔扁平苔藓(OLP)影响全球0.5%至1%的人口和所有人种。作为自身免疫过程触发因素并决定OLP外观的因素包括遗传易感性、皮肤损伤、病毒感染、接触性过敏和药物。OLP影响口腔黏膜,经常发生在脸颊内侧,很少发生在舌头、牙龈或嘴唇的边缘。这种情况表现为疼痛的腐蚀和口腔溃疡,伴有红斑和牙龈结垢,有时在汞合金填充物附近出现牙龈局部炎症。目前有132个基因参与OLP的发病机制,但似乎只有少数发挥主要作用。这些基因被称为“先导基因”。因此,基于生物信息学研究,参与OPL发病的主要基因有JUN、EGFR、FOS、IL2和ITGB4。虽然遗传状况、免疫系统背景和传染病被认为是最重要的归因和决定因素,但OLP的发病机制仍然知之甚少。为了实现研究结果的普遍性和加强所获得的结果,需要进一步的遗传学研究。
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引用次数: 1
Bond Strength to Dentine and Degree of Conversion of Adhesive Systems 与牙本质的结合强度和胶粘剂体系的转化程度
Pub Date : 2022-08-18 DOI: 10.24018/ejdent.2022.3.4.206
Vagner Flávio Reginato, S. Boccardi, Yasmin Bucco, V. Feitosa, A. Bacchi, R. Consani
Objectives: The study evaluated the bond strength, degree of conversion and fracture pattern of the hybrid layer in cement-dentin adhesion techniques.Materials and Methods: Bovine teeth dentin blocks were divided according to the cementation techniques: G1- Conventional three-step adhesive and dual-curing resin cement; G2- One-step self-etch adhesive and dual-curing resin cement; G3-Self-adhesive resin cement; and G4- Self-adhesive primer and dual-curing resin cement. Specimens were submitted to thermal cycling, chemical aging or water storage. Bond strength was evaluated by testing machine; fracture pattern observed by optical microscopy, and degree of conversion evaluated in micro-Raman spectrophotometer. Data were analyzed by two-way ANOVA and Tukey's test (α=0.05). Results: G1 showed greatest bond strength (p<0.001) followed by the G2 with higher values compared to G3 and G4, and no difference between them. For G2, G3 and G4, the thermal cycling affected the bond strength. The greatest degree of conversion was for G2 with Single Bond Universal, significantly higher than Scotchbond and RelyX U200. G4 provided highest value for the cement layer, and statistically higher than G1. G1 showed the highest strength than G3 associated to resin cement or self-adhesive resin cement. Different fracture patterns were observed.Conclusions: Aging methods reduced the bond strength. Degree of conversion was highest in the adhesive layer photo activated and in the cement layer with dual activation. Different fracture patterns were observed.Clinical Relevance: Resin cements degree of conversion and fracture pattern of the hybrid layer are relevant factors in the different bond strength values obtained in adhesive protocols.
目的:研究水泥-牙本质黏附技术中混杂层的黏附强度、转化程度和断裂方式。材料与方法:牛牙本质砌块按照胶结技术分为:G1-常规三步胶粘剂和双固化树脂胶粘剂;G2-一步自蚀刻胶双固化树脂水泥;g3 -自粘树脂水泥;G4—自粘底漆和双固化树脂水泥。标本经热循环、化学老化或水储存。通过试验机评估粘结强度;用光学显微镜观察断裂模式,用微拉曼分光光度计评估转换程度。数据采用双因素方差分析和Tukey检验(α=0.05)。结果:G1的粘结强度最高(p<0.001),其次是G2, G3和G4的粘结强度最高,两者之间无差异。对于G2、G3和G4,热循环影响粘结强度。单键Universal对G2的转化程度最大,显著高于Scotchbond和RelyX U200。G4为水泥层的最大值,且在统计学上高于G1。G1的强度高于G3与树脂水泥或自粘树脂水泥的强度。观察到不同的骨折模式。结论:老化方法降低了粘结强度。光活化胶粘剂层和双活化胶粘剂层的转化率最高。观察到不同的骨折模式。临床意义:树脂胶结物的转换程度和混杂层的断裂模式是粘接剂方案中获得不同粘接剂强度值的相关因素。
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引用次数: 0
Aesthetics with Single Implants in the Anterior Sector: What Experts Claim 美学与单一种植体在前段:什么专家声称
Pub Date : 2022-06-11 DOI: 10.24018/ejdent.2022.3.3.182
María Carmen López-Carriches, M. I. Leco-Berrocal, Setareh Linda Taheri, Ricardo Bahram Taheri
The objective of this article is to review the keys for the correct placement of implants in the anterior sector of the maxilla in order to achieve long-term implant success and, since it is an anterior sector, correct aesthetics. There should be a distance of at least 1.5 mm between the tooth and the implant, and ideally, the minimum vestibular thickness of bone of the implant should be 2 mm. Between implants the mesio-distal distance should be 3 mm and regarding the apico-coronal we should have at least 3 mm from the margin of the implant to the future restoration. The case must be planned carefully and we have to decide: when to place the implant, the provisional restoration, the type of implant, requirement of a graft, etc.
本文的目的是回顾在上颌前段种植体正确放置的关键,以实现长期种植成功,因为它是前段,正确的美学。牙齿与种植体之间的距离应至少为1.5 mm,理想情况下,种植体的前庭骨厚度应最小为2mm。种植体之间的中远端距离应为3mm,对于尖冠端,我们应该从种植体边缘到未来的修复体至少有3mm。病例必须仔细计划,我们必须决定:何时放置种植体,临时修复,种植体的类型,移植物的要求等。
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引用次数: 0
An Unusual Clinical Morphology of Bilateral Pleomorphic Adenoma with Unilateral Cystic Degeneration; a Consequence of Delay in Consent for Treatment: A Case Report 双侧多形性腺瘤合并单侧囊性变性的临床表现延迟同意治疗的后果:一个案例报告
Pub Date : 2022-06-09 DOI: 10.24018/ejdent.2022.3.3.193
Etetafia Okiemute Mabel
Background: Pleomorphic adenoma is the most common benign tumour of the salivary glands with majority found in the parotid gland. It accounts for 3% of all head and neck tumours and 70-80% of benign salivary gland tumours. The clinical features depend on the size, location and in some cases the potential to undergo malignant transformation. They are usually solitary, unilateral, firm and mobile, painless and slow growing, hence the long duration before presentation for treatment. Purpose: To present an 84-year-old female who first presented 16 years ago with a 4-year history of bilateral swellings at the left and right parotid regions, measuring 8.0 cm by 10.0 cm and 3.0 cm by 5.0 cm respectively. Due to fear of surgery, the patient gave consent for the excision of only the left lesion whose histology report came out to be pleomorphic adenoma. The right swelling was left in-situ. The time lapse of 16years resulted in gradual increase in size of the right lesion now measuring 12.0 cm by 8.0 cm with no clinical symptoms but aesthetically unpleasant to patient. With consent, the right lesion was excised and pathological examination showed a benign lesion composed of ovoid and spindle-shaped epithelial cells arranged in sheets and ducts, some of which contain eosinophilia coagulum and cystic degeneration in other foci. No evidence of malignancy. No post-operative recurrence on the left side16 years after and on the right side 24 months after treatment Conclusion: Pleomorphic adenoma can grow to enormous size, and with a potential to undergo cystic degeneration if left untreated. Early presentation for treatment is of high importance to prevent complications associated with delay.
背景:多形性腺瘤是唾液腺最常见的良性肿瘤,多数发生在腮腺。它占所有头颈部肿瘤的3%和良性唾液腺肿瘤的70-80%。临床特征取决于大小,位置和在某些情况下进行恶性转化的可能性。它们通常是孤立的,单侧的,坚固且可移动,无痛且生长缓慢,因此在就诊前持续时间长。目的:报告一名84岁女性,16年前首次出现,左侧和右侧腮腺区肿胀4年,分别为8.0 cm × 10.0 cm和3.0 cm × 5.0 cm。由于害怕手术,患者只同意切除左侧病变,病理报告显示为多形性腺瘤。右侧肿胀未发生。16年的时间流逝导致右侧病变逐渐增大,现在尺寸为12.0 cm × 8.0 cm,无临床症状,但患者审美不愉快。经同意,切除右侧病变,病理检查显示良性病变,卵球形和梭形上皮细胞呈片状和管状排列,部分病灶含有嗜酸性粒细胞凝固和其他病灶的囊性变性。无恶性证据。左侧术后16年无复发,右侧术后24个月无复发。结论:多形性腺瘤可长至巨大,如不及时治疗,有发生囊性变性的可能。早期就诊对预防因延误引起的并发症非常重要。
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引用次数: 0
Pyogenic Granuloma: A Literature Review and A Case Report 化脓性肉芽肿:文献回顾及1例报告
Pub Date : 2022-05-30 DOI: 10.24018/ejdent.2022.3.3.191
A. Georgoulis, Sofia Zarenti, Menelaos Anastasopoulos, A. Doufexi
Pyogenic granuloma of the oral cavity is a common, non-neoplastic, vascular tumor. The etiology is not clear and it is suggested to be attributed to different factors. It might be caused by a reaction to a stimulus such as trauma, viruses such as HSV-1, hormonal changes, as well as other factors such as tooth eruption or medication.  Clinically it appears as a painless tumor that tends to bleed easily, with red color and rarely may be accompanied by a periodontal abscess and bone loss. Biopsy is the most common tool used for the diagnosis. Its treatment is usually surgical excision and lately the use of lasers for its excision has emerged. Special care should be given to pregnant women where the treatment varies. The aim of this review is to present the background of oral pyogenic granuloma and the case report presents the situation, histological image and treatment of an adult woman patient.
口腔化脓性肉芽肿是一种常见的非肿瘤性血管性肿瘤。病因不明,可能与多种因素有关。它可能是由对创伤等刺激的反应、HSV-1等病毒、激素变化以及其他因素(如牙齿萌出或药物治疗)引起的。临床表现为无痛性肿瘤,易出血,颜色为红色,很少伴有牙周脓肿和骨质流失。活检是最常用的诊断工具。它的治疗通常是手术切除,最近使用激光切除已经出现。对于治疗方法不同的孕妇,应给予特别照顾。本文的目的是介绍口腔化脓性肉芽肿的背景和病例报告的情况,组织学图像和治疗的成年女性患者。
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引用次数: 1
Risk Stratification Tool to Develop Framework for Infection Control in Spectrum of Dental Procedures during COVID-19 Pandemic 制定2019冠状病毒病大流行期间牙科程序感染控制框架的风险分层工具
Pub Date : 2022-04-29 DOI: 10.24018/ejdent.2022.3.2.184
Beenish Abbas, S. Abbas, Iqra Saleem, Summiya Asghar, F. Gulfam, Muhammad Umair
Objective: To develop a framework for infection control in the spectrum of dental procedures during the COVID-19 pandemic. Methodology: The study was conducted from Oct to Dec 2021 after approval for ethical review board of Foundation university college of dentistry Ref no (    ). Patients undergoing various dental procedures were enrolled after written and verbal informed consent. Risk Stratification of each procedure was done applying novel risk assessment scoring system, according to the level of risk contact with saliva was given score 1, contact with blood scored as 2, production of aerosol (low level) through triple syringe was given score 3, high aerosol production by ultrasonic piezoelectric instruments was scored as 4. If the complete duration of the dental procedure was >60 min score assigned was 0.75, for procedures with 30 to 60 mins duration score specified was 0.50, if the duration of the procedure was less than 30 min score for that procedure was 0.25. For each patient total score of all these parameters was accumulated to grade risk of SARS -CoV-2 transmission as low (score <4), medium (score 4 to 6), or high (score >6) depending upon the accumulative score of each procedure. Results: Nine hundred and fifteen patients with a gender distribution of 163 (17.9%) males and 748 (82.1%) females with an age range < 18 – 45 years undergoing the dental procedure were enrolled. Out of 915, 436 (47.6%) procedures were found to be low risk, 38 (4.1%) moderate risk, and 437 (47.7%) high risk. Out of 174 maxillofacial procedures, only 18 (10.3%) were of high risk, similarly out of 113 orthodontics procedures, only 1 (0.9%) was of high risk and for 147 prosthodontic procedures, there were 55 (37.4%) high-risk procedures. On the other hand, for operative dentistry procedures (n=181), majority of 128 (70.7%) posed a high risk, among pediatrics procedures (n=92) there were 62 (67.4%) high-risk procedures and for periodontics (n=204) about 173 (84.8%) were of high-risk nature. Therefore, the majority of the high-risk procedures belonged to operative, pediatrics, and periodontics specialty as compared to other specialties (p<0.001). Conclusion: The majority of the high-risk dental procedures belonged to operative, pediatrics, and periodontics specialty as compared to other specialties.
目的:建立2019冠状病毒病大流行期间牙科手术感染控制框架。方法:本研究于2021年10月至12月进行,经基础大学牙科学院伦理审查委员会批准,文献编号()。接受各种牙科手术的患者在书面和口头知情同意后入组。应用新颖的风险评估评分系统对各环节进行风险分层,根据风险程度,唾液接触评分为1分,血液接触评分为2分,三针注射器产生气溶胶(低水平)评分为3分,超声压电仪器产生气溶胶(高水平)评分为4分。如果整个牙科手术持续时间大于60分钟,评分为0.75,对于30到60分钟的手术,评分为0.50,如果手术持续时间小于30分钟,评分为0.25。根据每个步骤的累积得分,累积每位患者所有这些参数的总分,将SARS -CoV-2传播风险评级为低(得分6)。结果:共纳入915例患者,其中男性163例(17.9%),女性748例(82.1%),年龄< 18 - 45岁。在915例手术中,436例(47.6%)为低风险,38例(4.1%)为中度风险,437例(47.7%)为高风险。174例颌面部手术中,高危手术仅18例(10.3%);113例正畸手术中,高危手术仅1例(0.9%);147例修复手术中,高危手术55例(37.4%)。另一方面,牙科手术(n=181) 128例高危手术中多数(70.7%),儿科手术(n=92)中62例(67.4%),牙周病(n=204)中173例(84.8%)为高危手术。因此,与其他专科相比,大多数高危手术属于外科、儿科和牙周病专科(p<0.001)。结论:与其他专科相比,高危牙科手术以外科、儿科和牙周病专科为主。
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引用次数: 0
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European Journal of Dental and Oral Health
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