Open Medicine最新文献_第9页

Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway 地奥司钦通过TLR4/NF-κB途径预防慢性前列腺炎

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine

Pub Date : 2024-09-13 DOI: 10.1515/med-2024-1036

Yan Long, Xiaodong Ge, Liangliang Ma, Junhua Guo, Yong Zhu

This study aimed to elucidate the effects and potential mechanisms of dioscin on chronic prostatitis (CP) in vivo and in vitro. CP models were constructed in vivo and in vitro and treated with different concentrations of dioscin. Hematoxylin and eosin staining was used to investigate the morphology of the prostate tissues. The concentration of inflammatory factors in prostate tissues was determined by enzyme-linked immunosorbent assay. The release of reactive oxygen species, malondialdehyde, superoxide dismutase, and catalase was measured using detection kits. P69 cell proliferation was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide. Furthermore, the activity of the TLR4/NF-κB signaling pathway was determined by quantitative reverse transcriptase polymerase chain reaction or Western blot assay. Histopathological data suggested that dioscin exerted protective effects against prostate morphological changes. Dioscin inhibits inflammatory cytokines and oxidative stress (OS) in prostate tissues in a concentration-dependent manner. Moreover, dioscin notably inhibited the activation of the TLR4/NF-κB signaling pathway in CP rats. In vitro, dioscin remarkably reduced lipopolysaccharide-induced P69 proliferation, inflammation, OS, and TLR4/NF-κB pathway activation in a dose-dependent manner. In conclusion, dioscin exerts a protective effect in CP by decreasing the inflammatory response and OS through the TLR4/NF-κB pathways. Our findings provide a novel latent therapy for dioscin for the treatment and prevention of CP.

本研究旨在阐明体内和体外利奥霉素对慢性前列腺炎（CP）的影响和潜在机制。研究人员在体内和体外构建了慢性前列腺炎模型，并使用不同浓度的地奥司霉素进行治疗。采用苏木精和伊红染色法研究前列腺组织的形态。酶联免疫吸附试验测定了前列腺组织中炎症因子的浓度。使用检测试剂盒测定活性氧、丙二醛、超氧化物歧化酶和过氧化氢酶的释放。P69 细胞增殖通过 3-（4，5-二甲基噻唑-2-基）-2，5-二苯基溴化四氮唑进行评估。此外，TLR4/NF-κB 信号通路的活性是通过定量逆转录酶聚合酶链反应或 Western 印迹法测定的。组织病理学数据表明，地奥司馨对前列腺形态变化具有保护作用。地奥司馨以浓度依赖性方式抑制前列腺组织中的炎性细胞因子和氧化应激（OS）。此外，地奥司馨还能显著抑制 CP 大鼠体内 TLR4/NF-κB 信号通路的激活。在体外，迪奥霉素以剂量依赖的方式显著减少了脂多糖诱导的P69增殖、炎症、OS和TLR4/NF-κB通路的激活。总之，地奥司嗪通过TLR4/NF-κB途径降低炎症反应和OS，对CP具有保护作用。我们的研究结果为治疗和预防心绞痛提供了一种新型的地奥辛潜伏疗法。

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引用次数: 0

Laboratory variables‐based artificial neural network models for predicting fatty liver disease: A retrospective study 基于实验室变量的人工神经网络模型预测脂肪肝：一项回顾性研究

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine

Pub Date : 2024-09-13 DOI: 10.1515/med-2024-1031

Panpan Lv, Zhen Cao, Zhengqi Zhu, Xiaoqin Xu, Zhen Zhao

Background The efficacy of artificial neural network (ANN) models employing laboratory variables for predicting fatty liver disease (FLD) remains inadequately established. The study aimed to develop ANN models to precisely predict FLD. Methods Of 12,058 participants undergoing the initial FLD screening, 7,990 eligible participants were included. A total of 6,309 participants were divided randomly into the training (4,415 participants, 70%) and validation (1,894 participants, 30%) sets for developing prediction models. The performance of ANNs was additionally tested in the testing set (1,681 participants). The area under the receiver operating characteristic curve (AUROC) was employed to assess the models’ performance. Results The 18-variable, 11-variable, 3-variable, and 2-variable models each achieved robust FLD prediction performance, with AUROCs over 0.92, 0.91, and 0.89 in the training, validation, and testing, respectively. Although slightly inferior to the other three models in performance (AUROC ranges: 0.89–0.92 vs 0.91–0.95), the 2-variable model showed 80.3% accuracy and 89.7% positive predictive value in the testing. Incorporating age and gender increased the AUROCs of the resulting 20-variable, 13-variable, 5-variable, and 4-variable models each to over 0.93, 0.92, and 0.91 in the training, validation, and testing, respectively. Conclusions Implementation of the ANN models could effectively predict FLD, with enhanced predictive performance via the inclusion of age and gender.

背景采用实验室变量的人工神经网络（ANN）模型在预测脂肪肝（FLD）方面的功效尚未得到充分证实。本研究旨在开发能精确预测脂肪肝的人工神经网络模型。方法在接受初步脂肪肝筛查的 12,058 名参与者中，纳入了 7,990 名符合条件的参与者。共有 6,309 名参与者被随机分为训练集（4,415 人，70%）和验证集（1,894 人，30%），用于开发预测模型。此外，还在测试集（1,681 名参与者）中测试了 ANN 的性能。采用接收者操作特征曲线下面积（AUROC）来评估模型的性能。结果 18 变量模型、11 变量模型、3 变量模型和 2 变量模型都取得了很好的 FLD 预测效果，在训练、验证和测试中的 AUROC 分别超过了 0.92、0.91 和 0.89。虽然在性能上略逊于其他三个模型（AUROC 范围：0.89-0.92 vs 0.91-0.95），但双变量模型在测试中显示出 80.3% 的准确率和 89.7% 的阳性预测值。纳入年龄和性别后，20 变量、13 变量、5 变量和 4 变量模型在训练、验证和测试中的 AUROC 分别增至 0.93、0.92 和 0.91 以上。结论 ANN 模型可以有效地预测 FLD，加入年龄和性别因素后，预测效果更佳。

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引用次数: 0

Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population 浙江汉族人群中 FBN1、MYH11 和 TGF-β 信号转导相关基因的多态性与散发性胸主动脉瘤和夹层的易感性的关系

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine

Pub Date : 2024-09-13 DOI: 10.1515/med-2024-1025

Shasha Yu, Lujie Huang, Jianfei Ren, Xiaoying Zhang

Background Sporadic thoracic aortic aneurysm and dissection (sTAAD) is a complicated vascular disease with a high mortality rate. And its genetic basis has not been fully explored. Method Here, 122 sTAAD patients and 98 healthy individuals were recruited, and 10 single nucleotide polymorphisms were selected and analyzed (FBN1 rs10519177, rs1036477, rs2118181, MYH11 rs115364997, rs117593370, TGFβ1 rs1800469, TGFβ2 rs900, TGFβR2 rs764522, rs1036095, and rs6785385). Moreover, multiple logistic regression analysis was used to evaluate gene–environment interactions. Results We identified that TGFβR2 rs1036095 dominant model CC + CG genotype (GT) (P = 0.004) may be a factor of increased risk of sTAAD, especially for women. FBN1 rs1036477 recessive model AA GT (P = 0.009) and FBN1 rs2118181 dominant model CC + CT GT (P = 0.009) were correlated to an increased death rate in sTAAD men patients. Gene–environment interactions indicated TGFβR2 rs1036095 dominant model (CC + CG)/GG to be a higher-risk factor for sTAAD (odds ratio = 3.255; 95% confidence interval: 1.324–8.000, P = 0.01). Conclusions TGFβR2 rs1036095, FBN1 rs1036477, and FBN1 rs2118181 were identified as factors of increased risk of sTAAD. Gene–environment interactions were associated with the risk of sTAAD.

背景散发性胸主动脉瘤和夹层（sTAAD）是一种复杂的血管疾病，死亡率很高。其遗传基础尚未得到充分探究。方法本文招募了 122 名 sTAAD 患者和 98 名健康人，选择并分析了 10 个单核苷酸多态性（FBN1 rs10519177、rs1036477、rs2118181、MYH11 rs115364997、rs117593370、TGFβ1 rs1800469、TGFβ2 rs900、TGFβR2 rs764522、rs1036095 和 rs6785385）。此外，还采用多元逻辑回归分析评估基因与环境的相互作用。结果我们发现，TGFβR2 rs1036095显性模型CC + CG基因型（GT）（P = 0.004）可能是增加sTAAD风险的一个因素，尤其是对女性而言。FBN1 rs1036477隐性模型AA GT（P = 0.009）和FBN1 rs2118181显性模型CC + CT GT（P = 0.009）与sTAAD男性患者的死亡率增加相关。基因与环境的相互作用表明，TGFβR2 rs1036095显性模型（CC + CG）/GG 是 sTAAD 的高危因素（几率比 = 3.255；95% 置信区间：1.324-8.000，P = 0.01）。结论 TGFβR2 rs1036095、FBN1 rs1036477 和 FBN1 rs2118181 被确定为 sTAAD 风险增加的因素。基因与环境的相互作用与 sTAAD 的风险有关。

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引用次数: 0

Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy 多参数磁共振图像-经直肠超声认知融合在前列腺活检中的应用价值

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine

Pub Date : 2024-09-13 DOI: 10.1515/med-2024-1026

Haichuan Yuan, Min Huang, Tao Liu, Wu Song, Chengpeng Luo

Objective To investigate the effect of three-dimensional (3D) reconstruction-assisted cognitive fusion in targeted prostate biopsy. Results There was no significant difference in the detection rate of prostate cancer (PCa) between targeted biopsy and systematic biopsy, and there was significant difference in the detection rate of clinically significant prostate cancer (csPCa) between targeted biopsy and systematic biopsy. In the low prostate total specific antigen (tPSA) group, there was no statistically significant difference in the detection rate of prostate cancer between the two biopsy modalities. However, compared with systematic puncture, targeted puncture had a higher detection rate for csPCa and a lower detection rate for clinically insignificant prostate cancer (ciPCa), and the difference was statistically significant. In the high tPSA group, there was no significant difference in the detection rate of PCa, csPCa, and ciPCa between the two biopsy types. Single needle positive rate of targeted puncture (29.77%) was significantly higher than that of systematic puncture (10.28%). Conclusions The detection rate of csPCa in 3D reconstruction-assisted cognitive fusion targeted prostate biopsy is better than that of 12-needle systematic biopsy, which markedly improved the positive rate of prostate biopsy.

目的研究三维重建辅助认知融合在前列腺靶向活检中的效果。结果靶向活组织检查和系统活组织检查的前列腺癌（PCa）检出率无明显差异，而靶向活组织检查和系统活组织检查的有临床意义的前列腺癌（csPCa）检出率有明显差异。在低前列腺总特异性抗原（tPSA）组中，两种活检方式的前列腺癌检出率差异无统计学意义。不过，与系统穿刺相比，靶向穿刺的 csPCa 检出率较高，而临床症状不明显的前列腺癌（ciPCa）检出率较低，且差异有统计学意义。在高 tPSA 组中，两种活检类型对 PCa、csPCa 和 ciPCa 的检出率无明显差异。靶向穿刺的单针阳性率（29.77%）明显高于系统穿刺（10.28%）。结论三维重建辅助认知融合靶向前列腺穿刺活检的 csPCa 检出率优于 12 针系统性穿刺活检，明显提高了前列腺穿刺活检的阳性率。

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引用次数: 0

Sleep quality associate with the increased prevalence of cognitive impairment in coronary artery disease patients: A retrospective case–control study 睡眠质量与冠心病患者认知障碍发生率的增加有关：一项回顾性病例对照研究

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine

Pub Date : 2024-09-11 DOI: 10.1515/med-2024-1034

Min Liu, Jianning Ma, Kena Bao, Ye Gu, Jing Zhao, Dongmei Ren, Fang Zhu, Xiangdong Xu

Background The pathogenesis of cognitive impairment (CI) in coronary artery disease (CAD) patients is still unclear and numerous influence factors could affect the CI status. The current studies suggest that sleep quality and behavior pattern are significant influence factors associated with CAD susceptibility. Methods A total of 223 participants including 90 CAD patients with CI and 133 controls were enrolled into this retrospective study. Demographic information, laboratory test results, clinical diagnostic data, and questionnaire survey were collected to recognize the influencing factors of CI in CAD patients. Appropriate statistical methods are used to analyze these collected data. Results Univariate analysis results of demographic information, laboratory test results, and questionnaire survey data revealed that the differences in fatigue symptom, age, HDL, TG, and sleep quality were statistically significant (p = 0.006, p = 0.000, p = 0.019, p = 0.028, and p = 0.037, respectively). Logistic regression analysis showed that age, fatigue, and sleep quality were the influence factors for CI in CAD population (p = 0.000, p = 0.035, and p = 0.017). Conclusions Sleep quality, fatigue, and age were associated with the increased susceptibility of CI in CAD patients. Both CI state and its related factors were involved in the pathological process of CAD, these findings could offer additional information for the prevention and control of CAD.

背景冠状动脉疾病（CAD）患者认知障碍（CI）的发病机制尚不清楚，有许多影响因素可能会影响认知障碍的状况。目前的研究表明，睡眠质量和行为模式是与 CAD 易感性相关的重要影响因素。方法这项回顾性研究共纳入 223 名参与者，其中包括 90 名伴有 CI 的 CAD 患者和 133 名对照者。研究收集了人口统计学信息、实验室检测结果、临床诊断数据和问卷调查，以了解 CAD 患者 CI 的影响因素。研究采用适当的统计学方法对收集到的数据进行分析。结果人口统计学信息、实验室检测结果和问卷调查数据的单变量分析结果显示，疲劳症状、年龄、高密度脂蛋白、总胆固醇和睡眠质量的差异具有统计学意义（分别为 p = 0.006、p = 0.000、p = 0.019、p = 0.028 和 p = 0.037）。逻辑回归分析表明，年龄、疲劳和睡眠质量是影响 CAD 患者 CI 的因素（p = 0.000、p = 0.035 和 p = 0.017）。结论睡眠质量、疲劳和年龄与 CAD 患者的 CI 易感性增加有关。CI状态及其相关因素均参与了CAD的病理过程，这些发现可为CAD的预防和控制提供更多信息。

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引用次数: 0

Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway 百草枯通过激活 PI3K/AKT 信号通路增加 IL-6 的表达和氧化应激，从而破坏血脑屏障

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine

Pub Date : 2024-09-11 DOI: 10.1515/med-2024-1020

Tao Liu, Fenshuang Zheng, Lin Liu, Hua Zhou, Tao Shen, Yanping Li, Wei Zhang

Background Paraquat (PQ) is a frequently used herbicide with neurotoxic effects after acute or chronic exposure. Although in vitro evidence supports the PQ toxicity to dopamine cells, its in vivo effects (especially the chronic exposure) remain ambiguous. In this study, we investigated the effect of chronic PQ exposure on the blood–brain barrier (BBB) damage and the underlying mechanisms. Methods Adult male Sprague Dawley rats and primary human brain microvascular endothelial (PHBME) cells were exposed to PQ as the animal and cell models. Evans Blue staining and hematoxylin & eosin staining were conducted to examine the BBB and brain tissue damages. The inflammatory cytokines were quantified via enzyme linked immunosorbent assay. The changes of PI3K/AKT signaling pathway were detected by western blot. Results PQ exposure can cause significant pathological lesions in the brain tissues and the BBB. IL-6 and reactive oxygen species levels were found to be significantly upregulated after PQ exposure in both the animal and cell models. PQ treatment could arrest the cell proliferation and migration in PHBME cells. PQ treatment promoted the phosphorylation of PI3K and AKT, and the application of PI3K inhibitor could attenuate PQ-induced IL-6 production, oxidative stress, BBB disruption, and brain tissue damage. Conclusion Our study demonstrated that chronic PQ exposure could impair the BBB function and induce brain tissue damage. The overactivation of the PI3K/AKT pathway, consequent upregulation of IL-6 production, and increased oxidative stress appear to mediate the inflammatory damage resulting from PQ exposure.

背景百草枯（PQ）是一种常用的除草剂，急性或慢性接触后会产生神经毒性。虽然体外证据支持百草枯对多巴胺细胞的毒性，但其体内效应（尤其是慢性暴露）仍不明确。在本研究中，我们研究了慢性 PQ 暴露对血脑屏障（BBB）损伤的影响及其潜在机制。方法以成年雄性 Sprague Dawley 大鼠和原代人脑微血管内皮细胞（PHBME）为动物和细胞模型，暴露于 PQ。采用伊文思蓝染色法和苏木精及伊红染色法检测 BBB 和脑组织损伤情况。通过酶联免疫吸附试验对炎症细胞因子进行定量分析。通过 Western 印迹检测 PI3K/AKT 信号通路的变化。结果 PQ 暴露可导致脑组织和 BBB 发生严重病变。在动物模型和细胞模型中，PQ暴露后IL-6和活性氧水平均显著上调。PQ能抑制PHBME细胞的增殖和迁移。PQ 处理可促进 PI3K 和 AKT 的磷酸化，而应用 PI3K 抑制剂可减轻 PQ 诱导的 IL-6 生成、氧化应激、BBB 破坏和脑组织损伤。结论我们的研究表明，长期暴露于 PQ 会损害 BBB 功能并诱导脑组织损伤。PI3K/AKT 通路的过度激活、IL-6 生成的随之上调以及氧化应激的增加似乎是 PQ 暴露导致炎症损伤的介导因素。

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引用次数: 0

The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae 肺炎支原体感染儿童的 IFN-γ、IL-10、IL-6 细胞因子以及病情严重程度与血清锌和铁的关系

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine

Pub Date : 2024-09-06 DOI: 10.1515/med-2024-0987

Yi Xu, Xiangyong Fei

Objective To explore the relationship between cytokines such as interferon γ (IFN-γ), interleukin-10 (IL-10), and interleukin-6 (IL-6), as well as the severity of the condition, and serum zinc (Zn) and Fe levels in children with Mycoplasma pneumoniae infection. Methods A simple random sampling method was used to select 108 children with Mycoplasma pneumoniae infection admitted to the hospital from January to December 2022 as the study subjects. Collect demographic data such as gender, age, and course of disease from all patients, as well as inflammatory cytokines (InCs) such as IFN-γ, IL-10, and IL-6, the severity of the condition, and serum trace element information such as Zn, Fe, calcium (Ca), and potassium (K) from all patients. Spearman correlation analysis was used to examine the relationship between IFN-γ, IL-10, IL-6, severity of illness, and Zn, Fe, Ca, K in children infected with Mycoplasma pneumoniae. Additionally, receiver operating characteristic (ROC) curve analysis was used to test the predictive efficacy of Zn, Fe, Ca, and K on the severity of the patient’s condition. Results This study included 108 children infected with Mycoplasma pneumoniae, of whom 6 had clinical data missing >10% and were all excluded. Finally, 102 complete clinical data were collected, with a data recovery efficiency of 94.44%. The differences in IFN-γ, IL-10, IL-6 levels, severity of the condition, as well as Zn, Fe, Ca, K levels among children of different ages, disease courses, body mass, and body temperature showed P < 0. 05. Spearman correlation analysis showed that the levels of IFN-γ, IL-10, IL-6, and severity of the condition in children with Mycoplasma pneumoniae infection were negatively correlated with Zn, Fe, Ca, and K (ρ = −0.319 to −0.827, P < 0.05). The ROC curve analysis results indicate that Zn, Fe, Ca, and K can all be used as indicators to predict the severity of the patient’s condition (AUC = 0.710–0.759, P < 0.05). Conclusion There is a close relationship between InCs and the severity of the condition in children with Mycoplasma pneumoniae and serum trace elements. Therefore, clinical attention should be paid to monitoring the serum trace element levels of children, and reasonable measures should be taken to regulate them to accelerate the progress of disease treatment.

摘要] 目的探讨肺炎支原体感染患儿体内干扰素γ（IFN-γ）、白细胞介素-10（IL-10）、白细胞介素-6（IL-6）等细胞因子、病情严重程度与血清锌（Zn）、铁（Fe）水平之间的关系。方法采用简单随机抽样方法，选取该院 2022 年 1 月至 12 月收治的 108 例肺炎支原体感染患儿作为研究对象。收集所有患者的性别、年龄、病程等人口统计学数据，以及IFN-γ、IL-10、IL-6等炎性细胞因子（InCs）、病情严重程度、Zn、Fe、Ca、K等血清微量元素信息。斯皮尔曼相关分析用于研究肺炎支原体感染儿童的 IFN-γ、IL-10、IL-6、病情严重程度和 Zn、Fe、Ca、K 之间的关系。此外，还使用接收器操作特征曲线（ROC）分析来检验 Zn、Fe、Ca 和 K 对患者病情严重程度的预测效果。结果本研究共纳入 108 名感染肺炎支原体的儿童，其中 6 名儿童的临床数据缺失>10%，全部排除。最后，收集到 102 项完整的临床数据，数据恢复效率为 94.44%。不同年龄、不同病程、不同体质、不同体温患儿的IFN-γ、IL-10、IL-6水平、病情严重程度以及Zn、Fe、Ca、K水平差异均显示P < 0.Spearman相关性分析表明，肺炎支原体感染患儿的IFN-γ、IL-10、IL-6水平及病情严重程度与Zn、Fe、Ca、K呈负相关（ρ = -0.319 to -0.827，P <0.05）。ROC 曲线分析结果表明，Zn、Fe、Ca 和 K 均可作为预测患者病情严重程度的指标（AUC = 0.710-0.759, P <0.05）。结论肺炎支原体感染患儿的 InCs 和病情严重程度与血清微量元素之间存在密切关系。因此，临床上应重视对患儿血清微量元素水平的监测，并采取合理措施进行调节，加快疾病治疗进度。

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引用次数: 0

Advanced neuroimaging and criminal interrogation in lie detection. 测谎中的高级神经成像和刑事审讯。

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine

Pub Date : 2024-09-05 eCollection Date: 2024-01-01 DOI: 10.1515/med-2024-1032

Valentina Opancina, Vladimir Sebek, Vladimir Janjic

Hidden information is the key to many security issues. If there is a reliable method to determine whether someone withholds information, many issues of this type can be resolved. However, until now, no method has proven to be reliable, but technical discoveries in the field of neuroimaging have caused a surge of new research in this area. Many neuroimaging techniques can be used, but functional magnetic resonance is the newest method, and its use in extracting and evaluating information from subjects could be the most significant, given that it records brain states in parallel with current mental activity/behavior, enabling the establishment of correlational links between them. Because the brain state displayed during fMRI imaging is the dependent variable measured during stimulus/task condition manipulation, it is necessary to use fMRI data in combination with complementary criminal interrogation techniques to gather information. This could be particularly important when standard interrogational techniques are not enough in order to preserve the common good, especially in "ticking bomb" situations. In this study, we review aspects of the possibility of utilizing advanced neuroimaging in combination with criminal interrogation in cases of serious criminal acts that threaten public safety.

隐藏信息是许多安全问题的关键所在。如果有一种可靠的方法可以确定某人是否隐瞒了信息，那么许多此类问题都可以迎刃而解。然而，到目前为止，还没有一种方法被证明是可靠的，但神经成像领域的技术发现引起了这一领域的新研究热潮。可以使用的神经成像技术有很多，但功能磁共振是最新的方法，它在提取和评估受试者信息方面的应用可能是最重要的，因为它可以同时记录大脑状态和当前的心理活动/行为，从而建立两者之间的相关联系。由于 fMRI 成像期间显示的大脑状态是刺激/任务条件操作期间测量的因变量，因此有必要将 fMRI 数据与辅助刑事审讯技术结合使用，以收集信息。当标准审讯技术不足以维护公共利益时，尤其是在 "定时炸弹 "情况下，这一点尤为重要。在本研究中，我们探讨了在威胁公共安全的严重犯罪行为案件中结合刑事审讯使用先进神经成像技术的可能性。

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引用次数: 0

Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy. 模仿面囊肱肌营养不良症的抗-HMGCR肌病

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine

Pub Date : 2024-09-04 eCollection Date: 2024-01-01 DOI: 10.1515/med-2024-1033

Andreas Albert Braun, Monika Atiya, Katja Göhner, Tibor Hortobagyi, Tobias Burkhardt, Bettina Schreiner

Introduction: Statin use can lead to various muscle-related issues, including benign creatine kinase (CK) elevations, myalgias, toxic myopathies, rhabdomyolysis, and immune-mediated necrotizing myositis (IMNM), which primarily affects older males. IMNM presents with proximal muscle weakness, elevated CK levels, and specific antibodies.

Case presentation: We describe a 72-year-old patient with muscle weakness persisting for over 3 years after statin therapy. Initially suspected to have a genetic disorder, further testing revealed elevated anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) antibodies, indicating immune-mediated myopathy. Despite the absence of inflammatory changes on biopsy, the patient responded positively to immune therapy.

Conclusion: This case highlights challenges in diagnosing immune-mediated myopathy, especially in older patients with atypical presentations. Testing for HMGCR antibodies can aid in diagnosis, particularly when inflammatory markers are absent. Awareness of red flags, such as delayed symptom onset and response to prednisone, is crucial for accurate diagnosis and management.

简介：使用他汀类药物可导致各种肌肉相关问题，包括良性肌酸激酶（CK）升高、肌痛、中毒性肌病、横纹肌溶解症和免疫介导的坏死性肌炎（IMNM），后者主要影响老年男性。免疫介导坏死性肌炎表现为近端肌无力、肌酸激酶水平升高和特异性抗体：我们描述了一位 72 岁的患者，他在接受他汀类药物治疗后，肌无力症状持续了 3 年多。最初怀疑患者患有遗传性疾病，但进一步检测发现抗 3-羟基-3-甲基戊二酰辅酶 A 还原酶（HMGCR）抗体升高，表明患者患有免疫介导的肌病。尽管活组织检查未发现炎症变化，但患者对免疫疗法反应良好：本病例凸显了诊断免疫介导的肌病所面临的挑战，尤其是对表现不典型的老年患者。检测 HMGCR 抗体有助于诊断，尤其是在炎症标记物缺失的情况下。认识到症状发作延迟和对泼尼松的反应等信号对于准确诊断和治疗至关重要。

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引用次数: 0

Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials. 营养支持对胃癌患者临床疗效的影响：随机对照试验荟萃分析。

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine

Pub Date : 2024-09-04 eCollection Date: 2024-01-01 DOI: 10.1515/med-2024-1023

Juping Zhang, Qian Kong, Jibo Zhang, Jun Guo

Background: Gastric cancer (GC) is a leading cause of cancer-related morbidity and mortality globally. This meta-analysis was conducted to assess the impact of nutritional interventions on clinical outcomes in GC patients.

Methods: Comprehensive search was conducted across four medical databases to identify randomized controlled trials (RCTs) that examined nutritional interventions in GC patients. The outcomes assessed included hospitalization duration, nutritional status, immune function, and complications.

Results: A total of 11 studies were included. Enteral nutrition (EN) significantly reduce hospital stay duration compared to no nutritional intervention (SMD = -1.22, 95% CI [-1.72, -0.73], P < 0.001) and parenteral nutrition (PN) (SMD = -1.30, 95% CI [-1.78, -0.82], P < 0.001), but showed no significant difference compared to immunonutrition (IN). EN also improved nutritional status, indicated by higher albumin prealbumin levels, and improved immune function by elevating CD4+ levels (SMD = 1.09, 95% CI [0.61, 1.57], P < 0.001). However, IN showed superior effects on immunoglobulin levels (IgG and IgM). No significant differences were observed in complication rates among EN, IN, and PN interventions.

Conclusion: Nutritional support, particularly EN and IN, can significantly improve hospitalization outcomes, nutritional status, and immune function. Customizing interventions according to patient requirements can optimize therapeutic outcomes, highlighting the need for further research in this area.

背景：胃癌（GC）是全球癌症相关发病率和死亡率的主要原因。本荟萃分析旨在评估营养干预对胃癌患者临床疗效的影响：在四个医学数据库中进行了全面搜索，以确定对胃癌患者进行营养干预的随机对照试验（RCT）。评估的结果包括住院时间、营养状况、免疫功能和并发症：结果：共纳入 11 项研究。与无营养干预（SMD = -1.22, 95% CI [-1.72, -0.73]，P < 0.001）和肠外营养（PN）（SMD = -1.30, 95% CI [-1.78, -0.82]，P < 0.001）相比，肠内营养（EN）可明显缩短住院时间，但与免疫营养（IN）相比无明显差异。免疫营养也改善了营养状况（表现为白蛋白前白蛋白水平升高），并通过提高 CD4+ 水平改善了免疫功能（SMD = 1.09，95% CI [0.61，1.57]，P <0.001）。不过，IN 对免疫球蛋白水平（IgG 和 IgM）的影响更大。在并发症发生率方面，EN、IN 和 PN 干预措施之间未发现明显差异：营养支持，尤其是 EN 和 IN，可显著改善住院效果、营养状况和免疫功能。根据患者需求定制干预措施可优化治疗效果，这也凸显了在该领域开展进一步研究的必要性。

{"title":"Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials.","authors":"Juping Zhang, Qian Kong, Jibo Zhang, Jun Guo","doi":"10.1515/med-2024-1023","DOIUrl":"10.1515/med-2024-1023","url":null,"abstract":"Background: Gastric cancer (GC) is a leading cause of cancer-related morbidity and mortality globally. This meta-analysis was conducted to assess the impact of nutritional interventions on clinical outcomes in GC patients.Methods: Comprehensive search was conducted across four medical databases to identify randomized controlled trials (RCTs) that examined nutritional interventions in GC patients. The outcomes assessed included hospitalization duration, nutritional status, immune function, and complications.Results: A total of 11 studies were included. Enteral nutrition (EN) significantly reduce hospital stay duration compared to no nutritional intervention (SMD = -1.22, 95% CI [-1.72, -0.73], P < 0.001) and parenteral nutrition (PN) (SMD = -1.30, 95% CI [-1.78, -0.82], P < 0.001), but showed no significant difference compared to immunonutrition (IN). EN also improved nutritional status, indicated by higher albumin prealbumin levels, and improved immune function by elevating CD4+ levels (SMD = 1.09, 95% CI [0.61, 1.57], P < 0.001). However, IN showed superior effects on immunoglobulin levels (IgG and IgM). No significant differences were observed in complication rates among EN, IN, and PN interventions.Conclusion: Nutritional support, particularly EN and IN, can significantly improve hospitalization outcomes, nutritional status, and immune function. Customizing interventions according to patient requirements can optimize therapeutic outcomes, highlighting the need for further research in this area.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"19 1","pages":"20241023"},"PeriodicalIF":1.7,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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