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Covert consciousness 隐蔽意识
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-01-10 DOI: 10.3233/nre-230123
Michael J. Young, Brian L. Edlow, Yelena G. Bodien
Covert consciousness is a state of residual awareness following severe brain injury or neurological disorder that evades routine bedside behavioral detection. Patients with covert consciousness have preserved awareness but are incapable of self-expression through ordinary means of behavior or communication. Growing recognition of the limitations of the bedside neurobehavioral examination in reliably detecting consciousness, along with advances in neurotechnologies capable of detecting brain states or subtle signs indicative of consciousness not discernible by routine examination, carry promise to transform approaches to classifying, diagnosing, prognosticating and treating disorders of consciousness. Here we describe and critically evaluate the evolving clinical category of covert consciousness, including approaches to its diagnosis through neuroimaging, electrophysiology, and novel behavioral tools, its prognostic relevance, and open questions pertaining to optimal clinical management of patients with covert consciousness recovering from severe brain injury.
隐蔽意识是指严重脑损伤或神经失调后的一种残余意识状态,它能躲过常规的床边行为检测。隐蔽意识患者的意识得以保留,但无法通过普通的行为或交流方式进行自我表达。越来越多的人认识到床边神经行为检查在可靠检测意识方面的局限性,同时神经技术的进步能够检测出常规检查无法辨别的大脑状态或指示意识的微妙迹象,这些都有望改变意识障碍的分类、诊断、预后和治疗方法。在此,我们将描述并批判性地评估隐蔽意识这一不断演变的临床类别,包括通过神经影像学、电生理学和新型行为学工具进行诊断的方法、其预后相关性,以及与严重脑损伤后隐蔽意识患者的最佳临床管理相关的开放性问题。
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引用次数: 0
Disorders of consciousness: A field in flux 意识障碍:不断变化的领域
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-01-09 DOI: 10.3233/nre-246000
C. Schnakers, N. Zasler
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引用次数: 0
Medical comorbidities in patients with prolonged disorder of consciousness: A narrative review 长期意识障碍患者的并发症:叙述性综述
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-01-09 DOI: 10.3233/nre-230130
Anna Estraneo, Marie-Michele Briand, Enrique Noé
BACKGROUND:A few studies specifically addressed medical comorbidities (MCs) in patients with severe acquired traumatic or non-traumatic brain injury and prolonged disorders of consciousness (pDoC; i.e., patients in vegetative state/unresponsive wakefulness syndrome, VS/UWS, or in minimally conscious state, MCS). OBJECTIVE:To provide an overview on incidence of MCs in patients with pDoC. METHODS:Narrative review on most impacting MCs in patients with pDoC, both those directly related to brain damage (epilepsy, neurosurgical complications, spasticity, paroxysmal sympathetic hyperactivity, PSH), and those related to severe disability and prolonged immobility (respiratory comorbidities, endocrine disorders and metabolic abnormalities, heterotopic ossifications). RESULTS:Patients with pDoC are at high risk to develop at least one MC. Moderate or severe respiratory and musculoskeletal comorbidities are the most common MCs. Epilepsy and PSH seem to be more frequent in patients in VS/UWS compared to patients in MCS, likely because of higher severity in the brain damage in VS. Endocrine metabolic, PSH and respiratory complications are less frequent in traumatic etiology, whereas neurogenic heterotopic ossifications are more frequent in traumatic etiology. Spasticity did not significantly differ between VS/UWS and MCS and in the three etiologies. MCs are associated with higher mortality rates, worse clinical improvement and can impact accuracy in the clinical diagnosis. CONCLUSIONS:The frequent occurrence of several MCs requires a specialized rehabilitative setting with high level of multidisciplinary medical expertise to prevent, appropriately recognize and treat them. Comprehensive rehabilitation could avoid possible progression to more serious complications that can negatively impact clinical outcomes.
背景:少数研究专门探讨了严重后天性创伤性或非创伤性脑损伤和长时间意识障碍(pDoC,即植物状态/无反应清醒综合征(VS/UWS)或微意识状态(MCS)患者的并发症(MCs)。目的:概述PDoC患者的MC发病率。方法:综述对pDoC患者影响最大的MCs,包括与脑损伤直接相关的MCs(癫痫、神经外科并发症、痉挛、阵发性交感神经活动亢进、PSH),以及与严重残疾和长期静止不动相关的MCs(呼吸系统合并症、内分泌紊乱和代谢异常、异位骨化)。结果:患有 pDoC 的患者极有可能患上至少一种 MC。中度或重度呼吸系统和肌肉骨骼并发症是最常见的 MC。癫痫和 PSH 似乎在 VS/UWS 患者中比在 MCS 患者中更为常见,这可能是因为 VS 患者的脑损伤更为严重。内分泌代谢、PSH 和呼吸系统并发症在创伤性病因中发生率较低,而神经源性异位骨化在创伤性病因中发生率较高。VS/UWS和MCS之间以及三种病因之间的痉挛没有明显差异。MCs与较高的死亡率、较差的临床改善有关,并会影响临床诊断的准确性。结论:多种 MCs 的频繁发生需要专业的康复环境和高水平的多学科医疗专家来预防、适当识别和治疗。全面的康复治疗可避免可能发展为更严重的并发症,从而对临床疗效产生负面影响。
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引用次数: 0
Swallowing dysfunctions in patients with disorders of consciousness: Evidence from neuroimaging data, assessment, and management 意识障碍患者的吞咽功能障碍:来自神经影像学数据、评估和管理的证据
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-01-08 DOI: 10.3233/nre-230135
Amandine Regnier, Evelyne Mélotte, Charlène Aubinet, Naji Alnagger, David Fischer, Aude Lagier, Aurore Thibaut, Steven Laureys, Jean-François Kaux, Olivia Gosseries
Following severe brain injuries, a subset of patients may remain in an altered state of consciousness; most of these patients require artificial feeding. Currently, a functional oral phase and the presence of exclusive oral feeding may constitute signs of consciousness. Additionally, the presence of pharyngo-laryngeal secretions, saliva aspiration, cough reflex and tracheostomy are related to the level of consciousness. However, the link between swallowing and consciousness is yet to be fully understood. The primary aim of this review is to establish a comprehensive overview of the relationship between an individual’s conscious behaviour and swallowing (reflexive and voluntary). Previous studies of brain activation during volitional and non-volitional swallowing tasks in healthy subjects are also reviewed. We demonstrate that the areas activated by voluntary swallowing tasks (primary sensorimotor, cingulate, insula, premotor, supplementary motor, cerebellum, and operculum) are not specific to deglutitive function but are shared with other motor tasks and brain networks involved in consciousness. This review also outlines suitable assessment and treatment methods for dysphagic patients with disorders of consciousness. Finally, we propose that markers of swallowing could contribute to the development of novel diagnostic guidelines for patients with disorders of consciousness.
严重脑损伤后,一部分患者可能会一直处于意识改变状态;这些患者大多需要人工喂养。目前,功能性口腔期和完全口腔进食可构成意识的迹象。此外,咽喉分泌物、唾液吸入、咳嗽反射和气管切开的存在也与意识水平有关。然而,吞咽与意识之间的联系仍有待全面了解。本综述的主要目的是全面概述个人意识行为与吞咽(反射性和自愿性)之间的关系。我们还回顾了以往对健康受试者在自主和非自主吞咽任务中大脑激活情况的研究。我们证明,自愿吞咽任务激活的区域(初级感觉运动区、扣带回、岛叶、前运动区、辅助运动区、小脑和小脑幕)并非专门针对吞咽功能,而是与其他运动任务和涉及意识的大脑网络共享。本综述还概述了针对意识障碍的吞咽困难患者的合适评估和治疗方法。最后,我们认为吞咽标记物有助于为意识障碍患者制定新的诊断指南。
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引用次数: 0
Medicolegal issues and disorders of consciousness 医疗法律问题和意识障碍
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-01-08 DOI: 10.3233/nre-230242
Nathan D. Zasler
BACKGROUND:The tasks and responsibilities that come with clinician involvement in medicolegal proceedings can be daunting and particularly so in challenging areas such as provision of medicolegal opinions in cases involving disorders of consciousness (DoC). OBJECTIVE:The aim of this narrative review was to provide education and advice to healthcare practitioners who by choice or circumstance are asked and/or required to provide medicolegal opinions in cases involving patients with DoC. METHODS:A literature search was conducted using PubMed Central and MedlinePlus for articles dealing with clinician involvement in medicolegal cases involving persons with DoC. The information provided also integrates the authors nearly 40 years of clinical experience and brain injury medicine practice and “trials and tribulations” associated with medicolegal involvement in such cases. RESULTS:The literature was found to be replete with articles on brain death and withdrawal/withholding of care (which are not the focus of this review). The extant medical literature in brain injury medicine on the other hand is currently lacking in practical information for clinicians working “in the trenches” regarding the challenges and caveats of medicoegal involvement in such cases. CONCLUSION:This review provides the reader with a big picture overview of the most pertinent medicolegal topics inherent in clinical work with patients with DOC including pertinent nomenclature, caveats regarding forensic consultation including independent medical examinations, testimony tips, discussion of life expectancy/median survival concepts, prognostication in a medicolegal context, documentation and record keeping as well as some of the specific challenges pertinent to these types of brain injury cases that are not per se relevant in less severe injuries.
背景:临床医生参与法医诉讼程序的任务和责任可能令人生畏,尤其是在具有挑战性的领域,例如在涉及意识障碍(DoC)的案件中提供法医意见。目的:本叙事性综述旨在为医疗从业人员提供教育和建议,因为在涉及意识障碍患者的案件中,他们会被要求或被要求提供医学法律意见。方法:我们使用 PubMed Central 和 MedlinePlus 进行了文献检索,以查找有关临床医生参与涉及 DoC 患者的医学法律案件的文章。所提供的信息还综合了作者近 40 年的临床经验和脑损伤医学实践,以及与此类案件中的法律诉讼相关的 "磨难"。结果:我们发现文献中充斥着关于脑死亡和撤出/暂停治疗的文章(这不是本综述的重点)。另一方面,脑损伤医学领域的现有医学文献目前缺乏实用信息,无法为 "在战壕中 "工作的临床医生提供有关此类病例中医疗法律介入的挑战和注意事项的信息。结论:本综述为读者提供了有关 DOC 患者临床工作中固有的最相关的医学法律主题的概览,包括相关术语、法医咨询(包括独立医学检查)的注意事项、证词提示、预期寿命/中位生存期概念的讨论、医学法律背景下的预后、文档和记录保存,以及与此类脑损伤病例相关的一些特定挑战,这些挑战本身与较轻的损伤无关。
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引用次数: 0
Dry needling combined with exercise therapy: Effects on wrist flexors spasticity in post-stroke patients - A randomized controlled trial. 干针疗法与运动疗法相结合:对中风后患者腕屈肌痉挛的影响--随机对照试验。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-01-01 DOI: 10.3233/NRE-230081
Seyedeh Saeideh Babazadeh-Zavieh, Noureddin Nakhostin Ansari, Nastaran Ghotbi, Soofia Naghdi, Seyed Mohammad Jafar Haeri

Background: The positive contribution of dry needling (DN) in conjunction with exercise therapy for patients with stroke and spasticity remains uncertain.

Objective: To examine the effects of DN combined with exercise therapy on wrist flexor spasticity and motor function in patients with stroke.

Methods: Twenty-four participants with stroke were randomly assigned to either the DN and exercise therapy group or the DN alone group. Assessments were conducted at baseline, after the 4th treatment session, and 3 weeks post-treatment.

Results: A significant Group×Time interaction was observed for wrist active range of motion (ROM) (P = 0.046), favoring the DN with exercise therapy group (∼10° at baseline, ∼15° immediately after the 4th session, and 15.4° at follow-up). The improvements in spasticity, passive ROM, and H-reflex latency were sustained during follow-up. However, there were no significant between-group differences in any outcome at any measurement time point.

Conclusion: The combined DN and exercise therapy did not exhibit superiority over DN alone concerning spasticity severity and motor function. However, it demonstrated additional advantages, particularly in improving motor neuron excitability and wrist passive extension.

背景:干针疗法(DN)与运动疗法相结合对中风和痉挛患者的积极作用仍不确定:目的:研究干针疗法与运动疗法相结合对中风患者腕屈肌痉挛和运动功能的影响:24 名中风患者被随机分配到 DN 和运动疗法组或单独 DN 组。分别在基线、第 4 次治疗后和治疗后 3 周进行评估:结果:在腕部主动活动范围(ROM)方面,观察到了明显的 "组×时间 "交互作用(P = 0.046),DN 与运动疗法组更受青睐(基线时为 10°,第 4 次治疗后为 15°,随访时为 15.4°)。在随访期间,痉挛、被动 ROM 和 H- 反射潜伏期的改善得以持续。然而,在任何测量时间点,组间结果均无明显差异:结论:在痉挛严重程度和运动功能方面,DN 和运动疗法联合疗法并不比单独使用 DN 更优越。结论:在痉挛严重程度和运动功能方面,DN 和运动疗法联合疗法并不比单独使用 DN 更有优势,但它显示出了额外的优势,尤其是在改善运动神经元兴奋性和腕关节被动伸展方面。
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引用次数: 0
Assessing consciousness and cognition in disorders of consciousness. 评估意识障碍中的意识和认知。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-01-01 DOI: 10.3233/NRE-230140
Caroline Schnakers

Detecting willful cognition in these patients is known to be challenging due to the patients' motor disabilities and high vigilance fluctuations but also due to the lack of expertise and use of adequate tools to assess these patients in specific settings. This review will discuss the main disorders of consciousness after severe brain injury, how to assess consciousness and cognition in these patients, as well as the challenges and tools available to overcome these challenges and reach an accurate diagnosis.

众所周知,由于患者的运动障碍和高度警觉性波动,同时也由于缺乏在特定环境中评估这些患者的专业知识和适当工具,检测这些患者的意志认知具有挑战性。本综述将讨论严重脑损伤后的主要意识障碍、如何评估这些患者的意识和认知,以及克服这些挑战并得出准确诊断所面临的挑战和可用的工具。
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引用次数: 0
Pediatric disorders of consciousness: Considerations, controversies, and caveats. 小儿意识障碍:考虑因素、争议和注意事项。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-01-01 DOI: 10.3233/NRE-230131
Beth Slomine, Erika Molteni

Pediatric disorders of consciousness (PedDOC) encompass conditions that may occur following very severe traumatic or other forms of acquired brain injury sustained during childhood. As in adults, PedDOC is described as a disturbance of awareness and/or responsiveness. PedDOC is a complex condition that requires specialized care, infrastructures, and technologies. PedDOC poses many challenges to healthcare providers and caregivers during recovery and throughout development. In this commentary, we intend to highlight some considerations, controversies, and caveats on the diagnosis, prognosis and treatment of PedDOC.

小儿意识障碍(PedDOC)包括儿童时期遭受非常严重的外伤或其他形式的后天脑损伤后可能出现的情况。与成人一样,小儿意识障碍被描述为意识和/或反应能力的紊乱。PedDOC 是一种复杂的病症,需要专门的护理、基础设施和技术。PedDOC 给医疗服务提供者和护理人员在康复和整个成长过程中带来了许多挑战。在本评论中,我们将重点介绍有关 PedDOC 诊断、预后和治疗的一些注意事项、争议和注意事项。
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引用次数: 0
Changes in self-perceived performance and satisfaction with performance of daily activities following interdisciplinary rehabilitation in people with late effects of polio. 小儿麻痹症晚期患者在接受跨学科康复治疗后,对日常活动表现的自我感觉和满意度的变化。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-01-01 DOI: 10.3233/NRE-230219
Katja Appelin, Lena-Karin Erlandsson, Jan Lexell, Eva Månsson Lexell

Background: People with late effects of polio (LEoP) may need rehabilitation to manage everyday life but knowledge of the benefits of interdisciplinary rehabilitation is limited.

Objective: To evaluate changes in performance and satisfaction with performance of activities among people with LEoP following interdisciplinary rehabilitation.

Methods: A pre-post retrospective study based on data on 102 participants with LEoP from a rehabilitation clinic. Changes in performance and satisfaction with performance of daily activities before and after interdisciplinary rehabilitation were assessed with the Canadian Occupational Performance Measure (COPM).

Results: There were statistically significant increases in the mean performance and mean satisfaction with performance COPM scores from admission to discharge. Twenty-three percent and 19% of the participants, respectively, had improved their performance and satisfaction with performance, 25% and 26% of the participants had no changes, and 19% and 22% of the participants, respectively, rated their performance and satisfaction lower at discharge compared to admission.

Conclusion: Interdisciplinary rehabilitation can enhance self-rated performance and satisfaction with performance of daily activities among people with LEoP. Future studies of rehabilitation for people with LEoP should use a prospective design and capture the participants' process of change related to their rehabilitation period.

背景:小儿麻痹症(LEoP)晚期患者可能需要通过康复来处理日常生活,但人们对跨学科康复的益处了解有限:评估小儿麻痹症晚期患者在接受跨学科康复治疗后活动能力和满意度的变化:方法:根据一家康复诊所的 102 名 LEoP 患者的数据,进行一项前后回顾性研究。采用加拿大职业表现测量法(COPM)对跨学科康复前后日常活动表现和满意度的变化进行评估:结果:从入院到出院,患者的平均工作表现和平均工作表现满意度 COPM 分数均有统计学意义上的大幅提高。分别有 23% 和 19% 的参与者的工作表现和满意度有所提高,25% 和 26% 的参与者的工作表现和满意度没有变化,分别有 19% 和 22% 的参与者在出院时对工作表现和满意度的评分低于入院时的评分:结论:跨学科康复可提高 LEoP 患者在日常活动中的自评表现和满意度。未来针对低视力障碍患者的康复研究应采用前瞻性设计,并捕捉参与者在康复期间的相关变化过程。
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引用次数: 0
Effect of acupuncture combined with lower limb gait rehabilitation robot on improving walking function in stroke patients with hemiplegia. 针灸结合下肢步态康复机器人对改善中风偏瘫患者行走功能的影响
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2024-01-01 DOI: 10.3233/NRE-230258
Chuan Hu, Xin Wang, Tongliang Pan

Background: No study has yet demonstrated the effect of lower limb gait rehabilitation robot treatment combined with acupuncture on stroke patients.

Objective: To explore the effect of acupuncture combined with lower limb gait rehabilitation robot on walking function in patients with hemiplegia after stroke.

Methods: Fifty-six patients with hemiplegia after stroke were enrolled and randomly divided into two groups. The control group received regular rehabilitation training and acupuncture therapy; the intervention group was additionally trained by AiWalker-I lower limb gait robot. Both groups received 5 sessions a week for 4 weeks. Walking function parameters were assessed before and after the 4-week treatment.

Results: There was no significant difference in all parameters between the two groups in baseline (P > 0.05). After 4 weeks of treatment, all parameters including the effectiveness of functional ambulation category (FAC), time up and go test (TUGT) time, Wisconsin gait scale (WGS) score, walking spatiotemporal parameters were all significantly improved in both groups with a significant better effect in the intervention group (P < 0.05).

Conclusion: Acupuncture combined with lower limb gait rehabilitation robot training has a positive effect on correction of abnormal gait and improvement of walking ability of hemiplegic patients after stroke.

背景:尚未有研究证实下肢步态康复机器人治疗结合针灸对中风患者的效果:目前还没有研究证实下肢步态康复机器人治疗联合针灸对脑卒中患者的效果:探讨针灸联合下肢步态康复机器人对脑卒中偏瘫患者步行功能的影响:方法:选取 56 例脑卒中偏瘫患者,随机分为两组。对照组接受常规康复训练和针灸疗法;干预组额外接受 AiWalker-I 下肢步态机器人训练。两组均每周接受 5 次训练,为期 4 周。在4周治疗前后对行走功能参数进行评估:结果:两组基线参数无明显差异(P>0.05)。治疗4周后,两组的所有参数,包括功能性行走类别(FAC)有效性、步行时间(TUGT)、威斯康星步态量表(WGS)评分、步行时空参数均有明显改善,其中干预组的效果明显更好(P 结论:针灸联合下肢运动康复治疗在改善下肢运动功能方面具有重要意义:针灸联合下肢步态康复机器人训练对脑卒中偏瘫患者步态异常的矫正和行走能力的改善有积极作用。
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引用次数: 0
期刊
NeuroRehabilitation
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