首页 > 最新文献

Periodontology 2000最新文献

英文 中文
Understanding exosomes: Part 1-Characterization, quantification and isolation techniques. 理解外泌体:第1部分——表征、定量和分离技术。
IF 18.6 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-02-01 Epub Date: 2023-09-22 DOI: 10.1111/prd.12520
Richard J Miron, Yufeng Zhang

Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with a diameter in the range of 30-150 nm. Their use has gained great momentum recently due to their ability to be utilized as diagnostic tools with a vast array of therapeutic applications. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be investigated. This review article first focuses on understanding exosomes, including their cellular origin, biogenesis, function, and characterization. Thereafter, overviews of the quantification methods and isolation techniques are given with discussion over their potential use as novel therapeutics in regenerative medicine.

外泌体是大多数细胞分泌的细胞外信号小泡的最小子集,直径在30-150nm范围内。由于它们能够被用作具有广泛治疗应用的诊断工具,因此它们的使用最近获得了巨大的势头。目前每年出版5000多篇关于这一主题的出版物,随着新的治疗策略的不断研究,这一数字预计只会急剧增加。这篇综述文章首先集中于理解外泌体,包括它们的细胞起源、生物发生、功能和表征。随后,对定量方法和分离技术进行了综述,并讨论了它们在再生医学中作为新疗法的潜在用途。
{"title":"Understanding exosomes: Part 1-Characterization, quantification and isolation techniques.","authors":"Richard J Miron, Yufeng Zhang","doi":"10.1111/prd.12520","DOIUrl":"10.1111/prd.12520","url":null,"abstract":"<p><p>Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with a diameter in the range of 30-150 nm. Their use has gained great momentum recently due to their ability to be utilized as diagnostic tools with a vast array of therapeutic applications. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be investigated. This review article first focuses on understanding exosomes, including their cellular origin, biogenesis, function, and characterization. Thereafter, overviews of the quantification methods and isolation techniques are given with discussion over their potential use as novel therapeutics in regenerative medicine.</p>","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":" ","pages":"231-256"},"PeriodicalIF":18.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Twenty-five years of recombinant human growth factors rhPDGF-BB and rhBMP-2 in oral hard and soft tissue regeneration. 重组人生长因子 rhPDGF-BB 和 rhBMP-2 在口腔软硬组织再生中的应用已有 25 年。
IF 18.6 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-02-01 Epub Date: 2023-09-08 DOI: 10.1111/prd.12522
Maria Elisa Galarraga-Vinueza, Shayan Barootchi, Marc L Nevins, Myron Nevins, Richard J Miron, Lorenzo Tavelli

Contemporary oral tissue engineering strategies involve recombinant human growth factor approaches to stimulate diverse cellular processes including cell differentiation, migration, recruitment, and proliferation at grafted areas. Recombinant human growth factor applications in oral hard and soft tissue regeneration have been progressively researched over the last 25 years. Growth factor-mediated surgical approaches aim to accelerate healing, tissue reconstruction, and patient recovery. Thus, regenerative approaches involving growth factors such as recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and recombinant human bone morphogenetic proteins (rhBMPs) have shown certain advantages over invasive traditional surgical approaches in severe hard and soft tissue defects. Several clinical studies assessed the outcomes of rhBMP-2 in diverse clinical applications for implant site development and bone augmentation. Current evidence regarding the clinical benefits of rhBMP-2 compared to conventional therapies is inconclusive. Nevertheless, it seems that rhBMP-2 can promote faster wound healing processes and enhance de novo bone formation, which may be particularly favorable in patients with compromised bone healing capacity or limited donor sites. rhPDGF-BB has been extensively applied for periodontal regenerative procedures and for the treatment of gingival recessions, showing consistent and positive outcomes. Nevertheless, current evidence regarding its benefits at implant and edentulous sites is limited. The present review explores and depicts the current applications, outcomes, and evidence-based clinical recommendations of rhPDGF-BB and rhBMPs for oral tissue regeneration.

当代口腔组织工程策略涉及重组人生长因子方法,以刺激各种细胞过程,包括移植区域的细胞分化、迁移、招募和增殖。在过去的 25 年中,重组人生长因子在口腔软硬组织再生中的应用得到了逐步研究。生长因子介导的手术方法旨在加速愈合、组织重建和患者康复。因此,在严重的硬组织和软组织缺损中,重组人血小板衍生生长因子-BB(rhPDGF-BB)和重组人骨形态发生蛋白(rhBMPs)等生长因子参与的再生方法与传统的侵入性手术方法相比显示出一定的优势。多项临床研究评估了 rhBMP-2 在不同临床应用中的效果,包括植入部位开发和骨增量。与传统疗法相比,rhBMP-2 的临床疗效目前尚无定论。不过,rhBMP-2 似乎能促进伤口更快愈合,并增强新骨形成,这对骨愈合能力受损或供体部位有限的患者尤其有利。rhPDGF-BB 已被广泛应用于牙周再生手术和牙龈凹陷治疗,并显示出一致的积极效果。然而,目前有关其在种植体和无牙颌部位的益处的证据还很有限。本综述探讨并描述了 rhPDGF-BB 和 rhBMPs 目前在口腔组织再生方面的应用、结果和循证临床建议。
{"title":"Twenty-five years of recombinant human growth factors rhPDGF-BB and rhBMP-2 in oral hard and soft tissue regeneration.","authors":"Maria Elisa Galarraga-Vinueza, Shayan Barootchi, Marc L Nevins, Myron Nevins, Richard J Miron, Lorenzo Tavelli","doi":"10.1111/prd.12522","DOIUrl":"10.1111/prd.12522","url":null,"abstract":"<p><p>Contemporary oral tissue engineering strategies involve recombinant human growth factor approaches to stimulate diverse cellular processes including cell differentiation, migration, recruitment, and proliferation at grafted areas. Recombinant human growth factor applications in oral hard and soft tissue regeneration have been progressively researched over the last 25 years. Growth factor-mediated surgical approaches aim to accelerate healing, tissue reconstruction, and patient recovery. Thus, regenerative approaches involving growth factors such as recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and recombinant human bone morphogenetic proteins (rhBMPs) have shown certain advantages over invasive traditional surgical approaches in severe hard and soft tissue defects. Several clinical studies assessed the outcomes of rhBMP-2 in diverse clinical applications for implant site development and bone augmentation. Current evidence regarding the clinical benefits of rhBMP-2 compared to conventional therapies is inconclusive. Nevertheless, it seems that rhBMP-2 can promote faster wound healing processes and enhance de novo bone formation, which may be particularly favorable in patients with compromised bone healing capacity or limited donor sites. rhPDGF-BB has been extensively applied for periodontal regenerative procedures and for the treatment of gingival recessions, showing consistent and positive outcomes. Nevertheless, current evidence regarding its benefits at implant and edentulous sites is limited. The present review explores and depicts the current applications, outcomes, and evidence-based clinical recommendations of rhPDGF-BB and rhBMPs for oral tissue regeneration.</p>","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":" ","pages":"483-509"},"PeriodicalIF":18.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10185656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Control of tissue homeostasis by the extracellular matrix: Synthetic heparan sulfate as a promising therapeutic for periodontal health and bone regeneration. 细胞外基质对组织稳态的控制:合成硫酸天门冬酰胺是牙周健康和骨再生的理想疗法。
IF 17.5 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-02-01 Epub Date: 2023-08-24 DOI: 10.1111/prd.12515
P A Miguez, E Bash, M L Musskopf, S A Tuin, A Rivera-Concepcion, I L C Chapple, J Liu

Proteoglycans are core proteins associated with carbohydrate/sugar moieties that are highly variable in disaccharide composition, which dictates their function. These carbohydrates are named glycosaminoglycans, and they can be attached to proteoglycans or found free in tissues or on cell surfaces. Glycosaminoglycans such as hyaluronan, chondroitin sulfate, dermatan sulfate, keratan sulfate, and heparin/heparan sulfate have multiple functions including involvement in inflammation, immunity and connective tissue structure, and integrity. Heparan sulfate is a highly sulfated polysaccharide that is abundant in the periodontium including alveolar bone. Recent evidence supports the contention that heparan sulfate is an important player in modulating interactions between damage associated molecular patterns and inflammatory receptors expressed by various cell types. The structure of heparan sulfate is reported to dictate its function, thus, the utilization of a homogenous and structurally defined heparan sulfate polysaccharide for modulation of cell function offers therapeutic potential. Recently, a chemoenzymatic approach was developed to allow production of many structurally defined heparan sulfate carbohydrates. These oligosaccharides have been studied in various pathological inflammatory conditions to better understand their function and their potential application in promoting tissue homeostasis. We have observed that specific size and sulfation patterns can modulate inflammation and promote tissue maintenance including an anabolic effect in alveolar bone. Thus, new evidence provides a strong impetus to explore heparan sulfate as a potential novel therapeutic agent to treat periodontitis, support alveolar bone maintenance, and promote bone formation.

蛋白聚糖是与碳水化合物/糖分子相关联的核心蛋白质,这些碳水化合物/糖分子的二糖组成变化很大,这决定了它们的功能。这些碳水化合物被命名为糖胺聚糖,它们可以附着在蛋白聚糖上,也可以游离在组织或细胞表面。透明质酸、硫酸软骨素、硫酸皮质素、硫酸角质素和肝素/硫酸肝素等糖胺聚糖具有多种功能,包括参与炎症、免疫、结缔组织结构和完整性。硫酸肝素是一种高度硫酸化的多糖,在牙周包括牙槽骨中含量丰富。最近有证据表明,硫酸肝素在调节损伤相关分子模式和各类细胞表达的炎症受体之间的相互作用方面发挥着重要作用。据报道,硫酸肝素的结构决定了它的功能,因此,利用同质且结构明确的硫酸肝素多糖来调节细胞功能具有治疗潜力。最近,人们开发出一种化学酶法,可以生产出许多结构明确的硫酸肝素碳水化合物。为了更好地了解这些寡糖的功能及其在促进组织稳态方面的潜在应用,我们对这些寡糖在各种病理炎症条件下的作用进行了研究。我们观察到,特定的大小和硫酸化模式可以调节炎症,促进组织维护,包括在牙槽骨中的同化作用。因此,新的证据为探索硫酸肝素作为治疗牙周炎、支持牙槽骨维护和促进骨形成的潜在新型治疗剂提供了强大的动力。
{"title":"Control of tissue homeostasis by the extracellular matrix: Synthetic heparan sulfate as a promising therapeutic for periodontal health and bone regeneration.","authors":"P A Miguez, E Bash, M L Musskopf, S A Tuin, A Rivera-Concepcion, I L C Chapple, J Liu","doi":"10.1111/prd.12515","DOIUrl":"10.1111/prd.12515","url":null,"abstract":"<p><p>Proteoglycans are core proteins associated with carbohydrate/sugar moieties that are highly variable in disaccharide composition, which dictates their function. These carbohydrates are named glycosaminoglycans, and they can be attached to proteoglycans or found free in tissues or on cell surfaces. Glycosaminoglycans such as hyaluronan, chondroitin sulfate, dermatan sulfate, keratan sulfate, and heparin/heparan sulfate have multiple functions including involvement in inflammation, immunity and connective tissue structure, and integrity. Heparan sulfate is a highly sulfated polysaccharide that is abundant in the periodontium including alveolar bone. Recent evidence supports the contention that heparan sulfate is an important player in modulating interactions between damage associated molecular patterns and inflammatory receptors expressed by various cell types. The structure of heparan sulfate is reported to dictate its function, thus, the utilization of a homogenous and structurally defined heparan sulfate polysaccharide for modulation of cell function offers therapeutic potential. Recently, a chemoenzymatic approach was developed to allow production of many structurally defined heparan sulfate carbohydrates. These oligosaccharides have been studied in various pathological inflammatory conditions to better understand their function and their potential application in promoting tissue homeostasis. We have observed that specific size and sulfation patterns can modulate inflammation and promote tissue maintenance including an anabolic effect in alveolar bone. Thus, new evidence provides a strong impetus to explore heparan sulfate as a potential novel therapeutic agent to treat periodontitis, support alveolar bone maintenance, and promote bone formation.</p>","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":" ","pages":"510-531"},"PeriodicalIF":17.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10891305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10126461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The development of non-resorbable bone allografts: Biological background and clinical perspectives. 非吸收性骨异体移植的发展:生物背景和临床前景。
IF 18.6 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-02-01 Epub Date: 2024-02-07 DOI: 10.1111/prd.12551
Richard J Miron, Masako Fujioka-Kobayashi, Michael A Pikos, Toshiaki Nakamura, Takatomo Imafuji, Yufeng Zhang, Yukiya Shinohara, Anton Sculean, Yoshinori Shirakata

Bone grafts are typically categorized into four categories: autografts, allografts, xenografts, and synthetic alloplasts. While it was originally thought that all bone grafts should be slowly resorbed and replaced with native bone over time, accumulating evidence has in fact suggested that the use of nonresorbable xenografts is favored for certain clinical indications. Thus, many clinicians take advantage of the nonresorbable properties/features of xenografts for various clinical indications, such as contour augmentation, sinus grafting, and guided bone regeneration, which are often combined with allografts (e.g., human freeze-dried bone allografts [FDBAs] and human demineralized freeze-dried bone allografts [DFDBAs]). Thus, many clinicians have advocated different 50/50 or 70/30 ratios of allograft/xenograft combination approaches for various grafting procedures. Interestingly, many clinicians believe that one of the main reasons for the nonresorbability or low substitution rates of xenografts has to do with their foreign animal origin. Recent research has indicated that the sintering technique and heating conducted during their processing changes the dissolution rate of hydroxyapatite, leading to a state in which osteoclasts are no longer able to resorb (dissolve) the sintered bone. While many clinicians often combine nonresorbable xenografts with the bone-inducing properties of allografts for a variety of bone augmentation procedures, clinicians are forced to use two separate products owing to their origins (the FDA/CE does not allow the mixture of allografts with xenografts within the same dish/bottle). This has led to significant progress in understanding the dissolution rates of xenografts at various sintering temperature changes, which has since led to the breakthrough development of nonresorbable bone allografts sintered at similar temperatures to nonresorbable xenografts. The advantage of the nonresorbable bone allograft is that they can now be combined with standard allografts to create a single mixture combining the advantages of both allografts and xenografts while allowing the purchase and use of a single product. This review article presents the concept with evidence derived from a 52-week monkey study that demonstrated little to no resorption along with in vitro data supporting this novel technology as a "next-generation" biomaterial with optimized bone grafting material properties.

骨移植通常分为四类:自体移植、异体移植、异种移植和合成异体。虽然人们最初认为所有的骨移植物都应该随着时间的推移慢慢吸收并被本地骨取代,但事实上,越来越多的证据表明,在某些临床适应症中,使用不可吸收的异种移植物更受青睐。因此,许多临床医生利用异种移植物的不吸收特性/特征,将其用于各种临床适应症,如轮廓增大、上颌窦移植和引导性骨再生,并经常与同种异体移植物(如人类冻干骨同种异体移植物[FDBAs]和人类去矿物质冻干骨同种异体移植物[DFDBAs])结合使用。因此,许多临床医生都主张在不同的移植手术中采用 50/50 或 70/30 不同比例的异体骨/异种骨组合方法。有趣的是,许多临床医生认为异种移植物不可吸收或替代率低的主要原因之一与异种动物来源有关。最近的研究表明,烧结技术和加工过程中的加热改变了羟基磷灰石的溶解速度,导致破骨细胞无法再吸收(溶解)烧结骨。虽然许多临床医生经常将不可吸收的异种移植物与具有骨诱导特性的异种移植物结合起来,用于各种骨增量手术,但由于其来源不同,临床医生不得不使用两种不同的产品(FDA/CE 不允许将异种移植物与异种移植物混合在同一盘/瓶中)。这使得人们在了解异种移植物在不同烧结温度变化下的溶解速率方面取得了重大进展,从而突破性地开发出了在与非吸收性异种移植物相似的温度下烧结的非吸收性骨异种移植物。不可吸收骨异体移植物的优势在于,它们现在可以与标准异体移植物结合,形成一种单一的混合物,结合了异体移植物和异种移植物的优点,同时允许购买和使用单一产品。这篇综述文章介绍了这一概念,其证据来自于一项为期 52 周的猴子研究,该研究表明几乎没有骨吸收,同时体外数据也支持这种新型技术成为具有优化骨移植材料特性的 "下一代 "生物材料。
{"title":"The development of non-resorbable bone allografts: Biological background and clinical perspectives.","authors":"Richard J Miron, Masako Fujioka-Kobayashi, Michael A Pikos, Toshiaki Nakamura, Takatomo Imafuji, Yufeng Zhang, Yukiya Shinohara, Anton Sculean, Yoshinori Shirakata","doi":"10.1111/prd.12551","DOIUrl":"10.1111/prd.12551","url":null,"abstract":"<p><p>Bone grafts are typically categorized into four categories: autografts, allografts, xenografts, and synthetic alloplasts. While it was originally thought that all bone grafts should be slowly resorbed and replaced with native bone over time, accumulating evidence has in fact suggested that the use of nonresorbable xenografts is favored for certain clinical indications. Thus, many clinicians take advantage of the nonresorbable properties/features of xenografts for various clinical indications, such as contour augmentation, sinus grafting, and guided bone regeneration, which are often combined with allografts (e.g., human freeze-dried bone allografts [FDBAs] and human demineralized freeze-dried bone allografts [DFDBAs]). Thus, many clinicians have advocated different 50/50 or 70/30 ratios of allograft/xenograft combination approaches for various grafting procedures. Interestingly, many clinicians believe that one of the main reasons for the nonresorbability or low substitution rates of xenografts has to do with their foreign animal origin. Recent research has indicated that the sintering technique and heating conducted during their processing changes the dissolution rate of hydroxyapatite, leading to a state in which osteoclasts are no longer able to resorb (dissolve) the sintered bone. While many clinicians often combine nonresorbable xenografts with the bone-inducing properties of allografts for a variety of bone augmentation procedures, clinicians are forced to use two separate products owing to their origins (the FDA/CE does not allow the mixture of allografts with xenografts within the same dish/bottle). This has led to significant progress in understanding the dissolution rates of xenografts at various sintering temperature changes, which has since led to the breakthrough development of nonresorbable bone allografts sintered at similar temperatures to nonresorbable xenografts. The advantage of the nonresorbable bone allograft is that they can now be combined with standard allografts to create a single mixture combining the advantages of both allografts and xenografts while allowing the purchase and use of a single product. This review article presents the concept with evidence derived from a 52-week monkey study that demonstrated little to no resorption along with in vitro data supporting this novel technology as a \"next-generation\" biomaterial with optimized bone grafting material properties.</p>","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":" ","pages":"161-179"},"PeriodicalIF":18.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139698032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disparities and social determinants of periodontal diseases. 牙周病的差异和社会决定因素。
IF 18.6 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-01-13 DOI: 10.1111/prd.12547
Jasim M Albandar

Periodontal diseases are highly prevalent in populations worldwide and are a major global public health problem, with major negative impacts on individuals and communities. This study investigates evidence of disparities in periodontal diseases by age groups, gender, and socioeconomic factors. There is ample evidence that these diseases disproportionally affect poorer and marginalized groups and are closely associated with certain demographics and socioeconomic status. Disparities in periodontal health are associated with social inequalities, which in turn are caused by old age, gender inequality, income and education gaps, access to health care, social class, and other factors. In health care, these factors may result in some individuals receiving better and more professional care compared to others. This study also reviews the potential causes of these disparities and the means to bridge the gap in disease prevalence. Identifying and implementing effective strategies to eliminate inequities among minorities and marginalized groups in oral health status and dental care should be prioritized in populations globally.

牙周病在全球人口中发病率很高,是一个重大的全球公共卫生问题,对个人和社区都有重大的负面影响。本研究调查了不同年龄组、性别和社会经济因素在牙周病方面存在差异的证据。大量证据表明,这些疾病对贫困和边缘化群体的影响尤为严重,并且与某些人口统计和社会经济地位密切相关。牙周健康的差异与社会不平等有关,而社会不平等又是由年龄、性别不平等、收入和教育差距、获得医疗保健的机会、社会阶层和其他因素造成的。在医疗保健方面,这些因素可能会导致一些人比其他人得到更好、更专业的护理。本研究还回顾了造成这些差异的潜在原因,以及缩小疾病患病率差距的方法。在全球范围内,确定并实施有效的战略,消除少数群体和边缘化群体在口腔健康状况和牙科护理方面的不平等现象,应成为各国人口的优先事项。
{"title":"Disparities and social determinants of periodontal diseases.","authors":"Jasim M Albandar","doi":"10.1111/prd.12547","DOIUrl":"https://doi.org/10.1111/prd.12547","url":null,"abstract":"<p><p>Periodontal diseases are highly prevalent in populations worldwide and are a major global public health problem, with major negative impacts on individuals and communities. This study investigates evidence of disparities in periodontal diseases by age groups, gender, and socioeconomic factors. There is ample evidence that these diseases disproportionally affect poorer and marginalized groups and are closely associated with certain demographics and socioeconomic status. Disparities in periodontal health are associated with social inequalities, which in turn are caused by old age, gender inequality, income and education gaps, access to health care, social class, and other factors. In health care, these factors may result in some individuals receiving better and more professional care compared to others. This study also reviews the potential causes of these disparities and the means to bridge the gap in disease prevalence. Identifying and implementing effective strategies to eliminate inequities among minorities and marginalized groups in oral health status and dental care should be prioritized in populations globally.</p>","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":" ","pages":""},"PeriodicalIF":18.6,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanical plaque removal in step-1 of care. 第一步护理中的机械性牙菌斑清除。
IF 18.6 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-12-26 DOI: 10.1111/prd.12541
G A Fridus Van der Weijden, Cor van Loveren

Maintaining a regular oral hygiene routine is essential for taking care of our mouths, ensuring healthy teeth, and achieving fresh breath. Patient education on oral hygiene is an important component of their overall treatment. Firstly, patients should be informed about the direct connection between bacteria in dental plaque and oral diseases. It is important for patients to understand that these conditions can be treated, but the success of treatment greatly depends on their level of oral hygiene. This journey begins by selecting the appropriate toothbrush and mastering the correct brushing technique to effectively remove dental plaque while avoiding any potential damage to the gums. In addition to toothbrushes, there are other devices available for comprehensive dental cleaning, such as floss, interdental sticks, interdental brushes, and oral irrigators. These aids are particularly beneficial for eliminating dental plaque from hard-to-reach areas. Moreover, tongue brushing or tongue scraping can effectively reduce breath odor and tongue coating. Currently, self-care recommendations for dental implants are primarily based on existing knowledge regarding natural teeth cleaning. Evidence-based recommendations are derived from comprehensive systematic evaluation of various oral hygiene aids.

保持规律的口腔卫生习惯对于护理我们的口腔、确保牙齿健康和获得清新口气至关重要。对患者进行口腔卫生教育是整体治疗的重要组成部分。首先,患者应了解牙菌斑中的细菌与口腔疾病之间的直接联系。患者必须明白,这些疾病是可以治疗的,但治疗的成功与否在很大程度上取决于他们的口腔卫生水平。首先要选择合适的牙刷,掌握正确的刷牙技巧,才能有效清除牙菌斑,同时避免对牙龈造成任何潜在伤害。除牙刷外,还有其他可用于全面清洁牙齿的设备,如牙线、牙间棒、牙间刷和口腔冲洗器。这些辅助工具对清除难以触及部位的牙菌斑特别有益。此外,刷舌或刮舌可以有效减少口腔异味和舌苔。目前,针对种植牙的自我护理建议主要基于现有的自然牙齿清洁知识。以证据为基础的建议来自对各种口腔卫生辅助工具的全面系统评估。
{"title":"Mechanical plaque removal in step-1 of care.","authors":"G A Fridus Van der Weijden, Cor van Loveren","doi":"10.1111/prd.12541","DOIUrl":"https://doi.org/10.1111/prd.12541","url":null,"abstract":"<p><p>Maintaining a regular oral hygiene routine is essential for taking care of our mouths, ensuring healthy teeth, and achieving fresh breath. Patient education on oral hygiene is an important component of their overall treatment. Firstly, patients should be informed about the direct connection between bacteria in dental plaque and oral diseases. It is important for patients to understand that these conditions can be treated, but the success of treatment greatly depends on their level of oral hygiene. This journey begins by selecting the appropriate toothbrush and mastering the correct brushing technique to effectively remove dental plaque while avoiding any potential damage to the gums. In addition to toothbrushes, there are other devices available for comprehensive dental cleaning, such as floss, interdental sticks, interdental brushes, and oral irrigators. These aids are particularly beneficial for eliminating dental plaque from hard-to-reach areas. Moreover, tongue brushing or tongue scraping can effectively reduce breath odor and tongue coating. Currently, self-care recommendations for dental implants are primarily based on existing knowledge regarding natural teeth cleaning. Evidence-based recommendations are derived from comprehensive systematic evaluation of various oral hygiene aids.</p>","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":" ","pages":""},"PeriodicalIF":18.6,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Periodontitis and risk of cancer: Mechanistic evidence 牙周炎与癌症风险:机制证据
IF 18.6 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-12-15 DOI: 10.1111/prd.12540
Giacomo Baima, Margherita Minoli, Dominique S. Michaud, Mario Aimetti, Mariano Sanz, Bruno G. Loos, Mario Romandini
This review aims to critically analyze the pathways of interaction and the pathogenic mechanisms linking periodontitis and oral bacteria with the initiation/progression of cancer at different body compartments. A higher risk of head and neck cancer has been consistently associated with periodontitis. This relationship has been explained by the local promotion of dysbiosis, chronic inflammation, immune evasion, and direct (epi)genetic damage to epithelial cells by periodontal pathobionts and their toxins. Epidemiological reports have also studied a possible link between periodontitis and the incidence of other malignancies at distant sites, such as lung, breast, prostate, and digestive tract cancers. Mechanistically, different pathways have been involved, including the induction of a chronic systemic inflammatory state and the spreading of oral pathobionts with carcinogenic potential. Indeed, periodontitis may promote low-grade systemic inflammation and phenotypic changes in the mononuclear cells, leading to the release of free radicals and cytokines, as well as extracellular matrix degradation, which are all mechanisms involved in carcinogenic and metastatic processes. Moreover, the transient hematogenous spill out or micro-aspiration/swallowing of periodontal bacteria and their virulence factors (i.e., lipopolysaccharides, fimbriae), may lead to non-indigenous bacterial colonization of multiple microenvironments. These events may in turn replenish the tumor-associated microbiome and thus influence the molecular hallmarks of cancer. Particularly, specific strains of oral pathobionts (e.g., Porphyromonas gingivalis and Fusobacterium nucleatum) may translocate through the hematogenous and enteral routes, being implicated in esophageal, gastric, pancreatic, and colorectal tumorigenesis through the modulation of the gastrointestinal antitumor immune system (i.e., tumor-infiltrating T cells) and the increased expression of pro-inflammatory/oncogenic genes. Ultimately, the potential influence of common risk factors, relevant comorbidities, and upstream drivers, such as gerovulnerability to multiple diseases, in explaining the relationship cannot be disregarded. The evidence analyzed here emphasizes the possible relevance of periodontitis in cancer initiation/progression and stimulates future research endeavors.
本综述旨在批判性地分析牙周炎和口腔细菌与人体不同部位癌症的发生/发展之间的相互作用途径和致病机制。头颈部癌症的高风险一直与牙周炎有关。牙周致病菌及其毒素在局部促进了菌群失调、慢性炎症、免疫逃避以及对上皮细胞的直接(外)遗传损伤,从而解释了这种关系。流行病学报告还研究了牙周炎与其他远处恶性肿瘤(如肺癌、乳腺癌、前列腺癌和消化道癌症)发病率之间可能存在的联系。从机理上讲,这涉及不同的途径,包括诱发慢性全身炎症状态和具有致癌潜力的口腔病原体的传播。事实上,牙周炎可促进低度全身炎症和单核细胞的表型变化,导致自由基和细胞因子的释放,以及细胞外基质的降解,这些都是致癌和转移过程中的相关机制。此外,牙周细菌及其毒力因子(即脂多糖、缘膜)的短暂血源性溢出或微吸入/吞咽可能导致非本地细菌在多个微环境中定植。这些事件可能反过来补充肿瘤相关微生物群,从而影响癌症的分子特征。特别是,口腔病原菌的特定菌株(如牙龈卟啉单胞菌和核酸镰刀菌)可能通过血源性和肠道途径转移,通过调节胃肠道抗肿瘤免疫系统(即肿瘤浸润 T 细胞)和增加促炎/致癌基因的表达,与食管、胃、胰腺和结直肠肿瘤的发生有关。归根结底,在解释这种关系时,不能忽视常见风险因素、相关合并症和上游驱动因素(如对多种疾病的老年易感性)的潜在影响。本文分析的证据强调了牙周炎在癌症发生/发展过程中可能存在的相关性,并激励着未来的研究工作。
{"title":"Periodontitis and risk of cancer: Mechanistic evidence","authors":"Giacomo Baima, Margherita Minoli, Dominique S. Michaud, Mario Aimetti, Mariano Sanz, Bruno G. Loos, Mario Romandini","doi":"10.1111/prd.12540","DOIUrl":"https://doi.org/10.1111/prd.12540","url":null,"abstract":"This review aims to critically analyze the pathways of interaction and the pathogenic mechanisms linking periodontitis and oral bacteria with the initiation/progression of cancer at different body compartments. A higher risk of head and neck cancer has been consistently associated with periodontitis. This relationship has been explained by the local promotion of dysbiosis, chronic inflammation, immune evasion, and direct (epi)genetic damage to epithelial cells by periodontal pathobionts and their toxins. Epidemiological reports have also studied a possible link between periodontitis and the incidence of other malignancies at distant sites, such as lung, breast, prostate, and digestive tract cancers. Mechanistically, different pathways have been involved, including the induction of a chronic systemic inflammatory state and the spreading of oral pathobionts with carcinogenic potential. Indeed, periodontitis may promote low-grade systemic inflammation and phenotypic changes in the mononuclear cells, leading to the release of free radicals and cytokines, as well as extracellular matrix degradation, which are all mechanisms involved in carcinogenic and metastatic processes. Moreover, the transient hematogenous spill out or micro-aspiration/swallowing of periodontal bacteria and their virulence factors (i.e., lipopolysaccharides, fimbriae), may lead to non-indigenous bacterial colonization of multiple microenvironments. These events may in turn replenish the tumor-associated microbiome and thus influence the molecular hallmarks of cancer. Particularly, specific strains of oral pathobionts (e.g., <i>Porphyromonas gingivalis</i> and <i>Fusobacterium nucleatum</i>) may translocate through the hematogenous and enteral routes, being implicated in esophageal, gastric, pancreatic, and colorectal tumorigenesis through the modulation of the gastrointestinal antitumor immune system (i.e., tumor-infiltrating T cells) and the increased expression of pro-inflammatory/oncogenic genes. Ultimately, the potential influence of common risk factors, relevant comorbidities, and upstream drivers, such as gerovulnerability to multiple diseases, in explaining the relationship cannot be disregarded. The evidence analyzed here emphasizes the possible relevance of periodontitis in cancer initiation/progression and stimulates future research endeavors.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":"4 1","pages":""},"PeriodicalIF":18.6,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138714178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological biomarkers of oral cancer 口腔癌的生物标志物
IF 18.6 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-12-10 DOI: 10.1111/prd.12542
Allan Radaic, Pachiyappan Kamarajan, Alex Cho, Sandy Wang, Guo-Chin Hung, Fereshteh Najarzadegan, David T. Wong, Hung Ton-That, Cun-Yu Wang, Yvonne L. Kapila
The oral squamous cell carcinoma (OSCC) 5 year survival rate of 41% has marginally improved in the last few years, with less than a 1% improvement per year from 2005 to 2017, with higher survival rates when detected at early stages. Based on histopathological grading of oral dysplasia, it is estimated that severe dysplasia has a malignant transformation rate of 7%–50%. Despite these numbers, oral dysplasia grading does not reliably predict its clinical behavior. Thus, more accurate markers predicting oral dysplasia progression to cancer would enable better targeting of these lesions for closer follow-up, especially in the early stages of the disease. In this context, molecular biomarkers derived from genetics, proteins, and metabolites play key roles in clinical oncology. These molecular signatures can help predict the likelihood of OSCC development and/or progression and have the potential to detect the disease at an early stage and, support treatment decision-making and predict treatment responsiveness. Also, identifying reliable biomarkers for OSCC detection that can be obtained non-invasively would enhance management of OSCC. This review will discuss biomarkers for OSCC that have emerged from different biological areas, including genomics, transcriptomics, proteomics, metabolomics, immunomics, and microbiomics.
口腔鳞状细胞癌(OSCC)的5年生存率为41%,在过去几年中略有改善,从2005年到2017年,每年改善不到1%,如果在早期发现,生存率会更高。根据口腔发育不良的组织病理学分级,估计严重发育不良的恶变率为 7%-50%。尽管有这些数字,但口腔发育不良的分级并不能可靠地预测其临床表现。因此,如果能有更准确的标志物来预测口腔发育不良向癌症的发展,就能更有针对性地对这些病变进行更密切的随访,尤其是在疾病的早期阶段。在这种情况下,来自遗传学、蛋白质和代谢物的分子生物标志物在临床肿瘤学中发挥着关键作用。这些分子特征有助于预测OSCC发展和/或恶化的可能性,并有可能在早期阶段发现疾病,支持治疗决策和预测治疗反应性。此外,确定用于检测 OSCC 的可靠生物标志物(可在无创情况下获得)将有助于加强对 OSCC 的管理。本综述将讨论从基因组学、转录物组学、蛋白质组学、代谢组学、免疫组学和微生物组学等不同生物学领域出现的 OSCC 生物标志物。
{"title":"Biological biomarkers of oral cancer","authors":"Allan Radaic, Pachiyappan Kamarajan, Alex Cho, Sandy Wang, Guo-Chin Hung, Fereshteh Najarzadegan, David T. Wong, Hung Ton-That, Cun-Yu Wang, Yvonne L. Kapila","doi":"10.1111/prd.12542","DOIUrl":"https://doi.org/10.1111/prd.12542","url":null,"abstract":"The oral squamous cell carcinoma (OSCC) 5 year survival rate of 41% has marginally improved in the last few years, with less than a 1% improvement per year from 2005 to 2017, with higher survival rates when detected at early stages. Based on histopathological grading of oral dysplasia, it is estimated that severe dysplasia has a malignant transformation rate of 7%–50%. Despite these numbers, oral dysplasia grading does not reliably predict its clinical behavior. Thus, more accurate markers predicting oral dysplasia progression to cancer would enable better targeting of these lesions for closer follow-up, especially in the early stages of the disease. In this context, molecular biomarkers derived from genetics, proteins, and metabolites play key roles in clinical oncology. These molecular signatures can help predict the likelihood of OSCC development and/or progression and have the potential to detect the disease at an early stage and, support treatment decision-making and predict treatment responsiveness. Also, identifying reliable biomarkers for OSCC detection that can be obtained non-invasively would enhance management of OSCC. This review will discuss biomarkers for OSCC that have emerged from different biological areas, including genomics, transcriptomics, proteomics, metabolomics, immunomics, and microbiomics.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":"196 1","pages":""},"PeriodicalIF":18.6,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138571974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal. 牙周炎和动脉粥样硬化性心血管疾病:一个关键的评估。
IF 18.6 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-11-23 DOI: 10.1111/prd.12528
Maria Clotilde Carra, Hélène Rangé, Giuseppina Caligiuri, Philippe Bouchard

In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. "Cardiovascular Diseases (CVDs)." WHO, February 1, 2017, https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)). Cardiovascular diseases are a group of disorders affecting the heart and blood vessels. They encompass a collection of different conditions, among which atherosclerotic cardiovascular disease (ASCVD) is the most prevalent. CVDs caused by atherosclerosis, that is, ASCVD, are particularly fatal: with heart attack and stroke being together the most prevalent cause of death in the world. To reduce the health burden represented by ASCVD, it is urgent to identify the nature of the "residual risk," beyond the established risk factors (e.g., hypertension) and behavioral factors already maximally targeted by drugs and public health campaigns. Remarkably, periodontitis is increasingly recognized as an independent cardiovascular risk factor.

尽管密集的研究工作推动了预防和治疗方面的惊人进展,但心血管疾病仍然是一个主要的健康负担,占所有死亡人数的32%(世界卫生组织)。心血管疾病(cvd)。世卫组织,2017年2月1日,https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)。心血管疾病是一组影响心脏和血管的疾病。它们包括一系列不同的疾病,其中动脉粥样硬化性心血管疾病(ASCVD)最为普遍。由动脉粥样硬化引起的心血管疾病,即ASCVD,特别致命:心脏病发作和中风是世界上最普遍的死亡原因。为了减轻ASCVD所代表的健康负担,迫切需要确定“剩余风险”的性质,而不是既定的风险因素(例如高血压)和药物和公共卫生运动已经最大限度地针对的行为因素。值得注意的是,牙周炎越来越被认为是一个独立的心血管危险因素。
{"title":"Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal.","authors":"Maria Clotilde Carra, Hélène Rangé, Giuseppina Caligiuri, Philippe Bouchard","doi":"10.1111/prd.12528","DOIUrl":"https://doi.org/10.1111/prd.12528","url":null,"abstract":"<p><p>In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. \"Cardiovascular Diseases (CVDs).\" WHO, February 1, 2017, https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)). Cardiovascular diseases are a group of disorders affecting the heart and blood vessels. They encompass a collection of different conditions, among which atherosclerotic cardiovascular disease (ASCVD) is the most prevalent. CVDs caused by atherosclerosis, that is, ASCVD, are particularly fatal: with heart attack and stroke being together the most prevalent cause of death in the world. To reduce the health burden represented by ASCVD, it is urgent to identify the nature of the \"residual risk,\" beyond the established risk factors (e.g., hypertension) and behavioral factors already maximally targeted by drugs and public health campaigns. Remarkably, periodontitis is increasingly recognized as an independent cardiovascular risk factor.</p>","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":" ","pages":""},"PeriodicalIF":18.6,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The natural history of periodontal disease-Part 2: In populations with access to dental care: The Studies of Health in Pomerania (SHIP). 牙周病的自然史第2部分:可获得牙科护理的人群:波美拉尼亚健康研究(SHIP)。
IF 18.6 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-10-25 DOI: 10.1111/prd.12535
Thomas Kocher, Peter Meisel, Reiner Biffar, Henry Völzke, Birte Holtfreter

In this descriptive analysis of the 21-year follow-up data from the SHIP-START cohort and the 7-year follow-up data from the SHIP-TREND cohort, we report the progression of clinical attachment levels (CAL), age effects on CAL change, and a detailed description of CAL progression and remission. At baseline, 4307 and 4420 persons participated in SHIP-START and SHIP-TREND, respectively. At the final follow-up, 1181 and 2507 subjects were available for evaluation, respectively. In SHIP-START and SHIP-TREND participants, the mean CAL progressed by 0.04 and 0.02 mm/year, respectively. The older the participants were, the lower the average annual change in mean CAL (from 0.043 to 0.031 mm/year); annual tooth loss was 0.11-0.14 teeth/year. When participants were ranked according to their annual change in mean CAL, remission was more frequently observed in older subjects. To correctly understand the data, it is important to realize that selection bias due to dropouts during follow-up favored younger and more health-conscious persons. In addition, extraction of severely periodontally compromised teeth during follow-up biased the progression towards zero. Another explanation for these low CAL progression rates is that most sites had little or no change in CAL; this means that CAL progression was partly offset by CAL remission. Therefore, changes in mean CAL do not adequately describe the temporal course of periodontitis. Older age was not a risk factor for CAL progression in either cohort.

在对SHIP-START队列的21年随访数据和SHIP-TREND队列的7年随访数据的描述性分析中,我们报告了临床依恋水平(CAL)的进展、年龄对CAL变化的影响,以及对CAL进展和缓解的详细描述。基线时,分别有4307人和4420人参加了SHIP-START和SHIP-TREND。在最后的随访中,分别有1181名和2507名受试者可供评估。在SHIP-START和SHIP-REND参与者中,平均CAL进步了0.04和0.02 mm/年。参与者年龄越大,平均CAL的年均变化越低(从0.043到0.031 mm/年);年牙齿脱落0.11-0.14颗/年。当参与者根据其平均CAL的年度变化进行排名时,在老年受试者中更频繁地观察到病情缓解。为了正确理解数据,重要的是要认识到,随访期间因辍学而产生的选择偏差有利于更年轻、更注重健康的人。此外,在随访期间,拔除严重牙周受损的牙齿使进展趋于零。对这些低CAL进展率的另一种解释是,大多数位点的CAL几乎没有变化;这意味着CAL进展被CAL缓解部分抵消。因此,平均CAL的变化不能充分描述牙周炎的时间进程。年龄较大不是两组患者CAL进展的危险因素。
{"title":"The natural history of periodontal disease-Part 2: In populations with access to dental care: The Studies of Health in Pomerania (SHIP).","authors":"Thomas Kocher,&nbsp;Peter Meisel,&nbsp;Reiner Biffar,&nbsp;Henry Völzke,&nbsp;Birte Holtfreter","doi":"10.1111/prd.12535","DOIUrl":"https://doi.org/10.1111/prd.12535","url":null,"abstract":"<p><p>In this descriptive analysis of the 21-year follow-up data from the SHIP-START cohort and the 7-year follow-up data from the SHIP-TREND cohort, we report the progression of clinical attachment levels (CAL), age effects on CAL change, and a detailed description of CAL progression and remission. At baseline, 4307 and 4420 persons participated in SHIP-START and SHIP-TREND, respectively. At the final follow-up, 1181 and 2507 subjects were available for evaluation, respectively. In SHIP-START and SHIP-TREND participants, the mean CAL progressed by 0.04 and 0.02 mm/year, respectively. The older the participants were, the lower the average annual change in mean CAL (from 0.043 to 0.031 mm/year); annual tooth loss was 0.11-0.14 teeth/year. When participants were ranked according to their annual change in mean CAL, remission was more frequently observed in older subjects. To correctly understand the data, it is important to realize that selection bias due to dropouts during follow-up favored younger and more health-conscious persons. In addition, extraction of severely periodontally compromised teeth during follow-up biased the progression towards zero. Another explanation for these low CAL progression rates is that most sites had little or no change in CAL; this means that CAL progression was partly offset by CAL remission. Therefore, changes in mean CAL do not adequately describe the temporal course of periodontitis. Older age was not a risk factor for CAL progression in either cohort.</p>","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":" ","pages":""},"PeriodicalIF":18.6,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50162421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Periodontology 2000
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1