Jacqueline Lake, Chiara C Bortolasci, Amanda L Stuart, Julie A Pasco, Srisaiyini Kidnapillai, Briana Spolding, Trang T T Truong, Bruna Panizzutti, Zoe S J Liu, Olivia M Dean, Tamsyn Crowley, Mark Richardson, Jee Hyun Kim, Michael Berk, Lana J Williams, Ken Walder
Introduction: Mood disorders are a major cause of disability, and current treatment options are inadequate for reducing the burden on a global scale. The aim of this project was to identify drugs suitable for repurposing to treat mood disorders.
Methods: This mixed-method study utilized gene expression signature technology and pharmacoepidemiology to investigate drugs that may be suitable for repurposing to treat mood disorders.
Results: The transcriptional effects of a combination of drugs commonly used to treat mood disorders included regulation of the steroid and terpenoid backbone biosynthesis pathways, suggesting a mechanism involving cholesterol biosynthesis, and effects on the thyroid hormone signaling pathway. Connectivity Map analysis highlighted metformin, an FDA-approved treatment for type 2 diabetes, as a drug having global transcriptional effects similar to the mood disorder drug combination investigated. In a retrospective cohort study, we found evidence that metformin is protective against the onset of mood disorders.
Discussion: These results provide proof-of-principle of combining gene expression signature technology with pharmacoepidemiology to identify potential novel drugs for treating mood disorders. Importantly, metformin may have utility in the treatment of mood disorders, warranting future randomized controlled trials to test its efficacy.
{"title":"Metformin is Protective Against the Development of Mood Disorders.","authors":"Jacqueline Lake, Chiara C Bortolasci, Amanda L Stuart, Julie A Pasco, Srisaiyini Kidnapillai, Briana Spolding, Trang T T Truong, Bruna Panizzutti, Zoe S J Liu, Olivia M Dean, Tamsyn Crowley, Mark Richardson, Jee Hyun Kim, Michael Berk, Lana J Williams, Ken Walder","doi":"10.1055/a-1936-3580","DOIUrl":"https://doi.org/10.1055/a-1936-3580","url":null,"abstract":"<p><strong>Introduction: </strong>Mood disorders are a major cause of disability, and current treatment options are inadequate for reducing the burden on a global scale. The aim of this project was to identify drugs suitable for repurposing to treat mood disorders.</p><p><strong>Methods: </strong>This mixed-method study utilized gene expression signature technology and pharmacoepidemiology to investigate drugs that may be suitable for repurposing to treat mood disorders.</p><p><strong>Results: </strong>The transcriptional effects of a combination of drugs commonly used to treat mood disorders included regulation of the steroid and terpenoid backbone biosynthesis pathways, suggesting a mechanism involving cholesterol biosynthesis, and effects on the thyroid hormone signaling pathway. Connectivity Map analysis highlighted metformin, an FDA-approved treatment for type 2 diabetes, as a drug having global transcriptional effects similar to the mood disorder drug combination investigated. In a retrospective cohort study, we found evidence that metformin is protective against the onset of mood disorders.</p><p><strong>Discussion: </strong>These results provide proof-of-principle of combining gene expression signature technology with pharmacoepidemiology to identify potential novel drugs for treating mood disorders. Importantly, metformin may have utility in the treatment of mood disorders, warranting future randomized controlled trials to test its efficacy.</p>","PeriodicalId":19783,"journal":{"name":"Pharmacopsychiatry","volume":"56 1","pages":"25-31"},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10469482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Although several randomized controlled trials (RCTs) have compared the effectiveness, efficacy, and safety of antipsychotic monotherapy (APM) versus placebo in patients with major depressive disorder (MDD), no meta-analysis has examined this topic. We conducted a systematic literature search using MEDLINE and Embase to identify relevant RCTs and performed a meta-analysis to compare the following outcomes between APM and placebo: response and remission rates, study discontinuation due to all causes, lack of efficacy, and adverse events, changes in total scores on depression severity scales, and individual adverse event rates. A total of 13 studies were identified, with 14 comparisons involving 3,197 participants that met the eligibility criteria. There were significant differences between APM and placebo in response and remission rates and changes in the primary depression severity scale in favor of APM, and study discontinuation due to adverse events and several individual adverse events in favor of placebo. No significant difference was observed in discontinuation due to all causes. APM could have antidepressant effects in the acute phase of MDD, although clinicians should be aware of an increased risk of some adverse events.
{"title":"Antipsychotic Monotherapy for Major Depressive Disorder: A Systematic Review and Meta-Analysis.","authors":"Akira Nishi, Kyosuke Sawada, Hiroyuki Uchida, Masaru Mimura, Hiroyoshi Takeuchi","doi":"10.1055/a-1934-9856","DOIUrl":"https://doi.org/10.1055/a-1934-9856","url":null,"abstract":"<p><p>Although several randomized controlled trials (RCTs) have compared the effectiveness, efficacy, and safety of antipsychotic monotherapy (APM) versus placebo in patients with major depressive disorder (MDD), no meta-analysis has examined this topic. We conducted a systematic literature search using MEDLINE and Embase to identify relevant RCTs and performed a meta-analysis to compare the following outcomes between APM and placebo: response and remission rates, study discontinuation due to all causes, lack of efficacy, and adverse events, changes in total scores on depression severity scales, and individual adverse event rates. A total of 13 studies were identified, with 14 comparisons involving 3,197 participants that met the eligibility criteria. There were significant differences between APM and placebo in response and remission rates and changes in the primary depression severity scale in favor of APM, and study discontinuation due to adverse events and several individual adverse events in favor of placebo. No significant difference was observed in discontinuation due to all causes. APM could have antidepressant effects in the acute phase of MDD, although clinicians should be aware of an increased risk of some adverse events.</p>","PeriodicalId":19783,"journal":{"name":"Pharmacopsychiatry","volume":"56 1","pages":"5-17"},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10482603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anastasia Gaspert, R. Schülke, Tabea Bätge, T. Folsche, N. Mahmoudi, Mike Wattjes, C. Sinke, Tillmann Krüger, S. Bleich, A. Neyazi, H. Frieling, H. Maier
{"title":"Functional connectivity analysis of locus coeruleus in patients with\u0000 major depressive episode","authors":"Anastasia Gaspert, R. Schülke, Tabea Bätge, T. Folsche, N. Mahmoudi, Mike Wattjes, C. Sinke, Tillmann Krüger, S. Bleich, A. Neyazi, H. Frieling, H. Maier","doi":"10.1055/s-0042-1757657","DOIUrl":"https://doi.org/10.1055/s-0042-1757657","url":null,"abstract":"","PeriodicalId":19783,"journal":{"name":"Pharmacopsychiatry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48298272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Grenzer, A. Juhl, D. Fitzner, J. Wiltfang, Niels Hansen
{"title":"Psychiatric syndromes associated with anti-neural autoantibodies\u0000 differ in their affective psychopathology from those that are\u0000 not","authors":"I. Grenzer, A. Juhl, D. Fitzner, J. Wiltfang, Niels Hansen","doi":"10.1055/s-0042-1757642","DOIUrl":"https://doi.org/10.1055/s-0042-1757642","url":null,"abstract":"","PeriodicalId":19783,"journal":{"name":"Pharmacopsychiatry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42365104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Schülke, K. Liepach, AnnaL Brömstrup, T. Folsche, M. Deest, S. Bleich, A. Neyazi, H. Frieling, H. Maier
{"title":"Neurological soft signs are increased in major depressive disorder\u0000 irrespective of antidepressant treatment","authors":"R. Schülke, K. Liepach, AnnaL Brömstrup, T. Folsche, M. Deest, S. Bleich, A. Neyazi, H. Frieling, H. Maier","doi":"10.1055/s-0042-1757665","DOIUrl":"https://doi.org/10.1055/s-0042-1757665","url":null,"abstract":"","PeriodicalId":19783,"journal":{"name":"Pharmacopsychiatry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47137084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fromut von Oertzen, E. Schneider, Maxim Fischer, B. Ditzen, M. Eckstein
{"title":"Processing and recall of safety- and threat cues: The influence of\u0000 oxytocin and the menstrual cycle","authors":"Fromut von Oertzen, E. Schneider, Maxim Fischer, B. Ditzen, M. Eckstein","doi":"10.1055/s-0042-1757661","DOIUrl":"https://doi.org/10.1055/s-0042-1757661","url":null,"abstract":"","PeriodicalId":19783,"journal":{"name":"Pharmacopsychiatry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41376153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kuzin, G. Schoretsanitis, Markus Götschi, F. Gardin, W. Kawohl, Franziskos Xepapadakos
{"title":"Bariatric surgery: impact on oral aripiprazole and fluoxetine\u0000 bioavailability – A clinical case","authors":"M. Kuzin, G. Schoretsanitis, Markus Götschi, F. Gardin, W. Kawohl, Franziskos Xepapadakos","doi":"10.1055/s-0042-1757673","DOIUrl":"https://doi.org/10.1055/s-0042-1757673","url":null,"abstract":"","PeriodicalId":19783,"journal":{"name":"Pharmacopsychiatry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47559752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Faltraco, D. Palm, A. Uzoni, O. Tucha, J. Thome
{"title":"Low glucose influences Clock expression in study participants with an\u0000 ADHD diagnosis","authors":"F. Faltraco, D. Palm, A. Uzoni, O. Tucha, J. Thome","doi":"10.1055/s-0042-1757654","DOIUrl":"https://doi.org/10.1055/s-0042-1757654","url":null,"abstract":"","PeriodicalId":19783,"journal":{"name":"Pharmacopsychiatry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47842066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Caffeine augmentation in electroconvulsive therapy","authors":"Else Schneider, A. Brühl","doi":"10.1055/s-0042-1757646","DOIUrl":"https://doi.org/10.1055/s-0042-1757646","url":null,"abstract":"","PeriodicalId":19783,"journal":{"name":"Pharmacopsychiatry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42847471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Age-dependent stimulus dose increase during an acute ECT\u0000 series","authors":"Jana Plemper, S. Karl, A. Sartorius","doi":"10.1055/s-0042-1757645","DOIUrl":"https://doi.org/10.1055/s-0042-1757645","url":null,"abstract":"","PeriodicalId":19783,"journal":{"name":"Pharmacopsychiatry","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46365706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号