Introduction: This study aims to determine the relationship between vascular calcification, carotid artery intima-media thickness (CIMT) and malnutrition with inflammatory parameters in dialysis patients. Materials and Methods: 140 CKD patients and 44 healthy controls were included in the study. CIMT was measured by ultrasonography. Valvular calcification was assessed by echocardiography and vascular calcification scores (VCS) were done based on the radiograms. Biochemical parameters were assessed using routine laboratory methods. Subjective global assessment (SGA) was used to evaluate malnutrition. Results: In the study, VCS showed no differences between hemodialysis (HD) and peritoneal dialysis (PD) patients (1.84±2.35 for HD, 1.77±1.64 for PD; p:0.83). CIMT, Osteopontin (OPN), interleukin-6 (IL-6) and homocysteine were significantly different in both dialysis groups compared to healthy controls. The Mean carotid intima-media thickness (m-CIMT) was higher in HD patients compared to PD group. CIMT, vascular calcification and SGA scores showed positive correlation with age, dialysis duration and valvular calcification grades, and negative correlation with albumin levels. A positive correlation between SGA scores and high-sensitive C-reactive protein (hs-CRP) levels was also noted. On multiple regression analysis, m-CIMT was independently associated with age, VCS and albumin levels. VCS was found to be independently associated with only albumin levels. Conclusion: Vascular and valvular calcification, an indicator of cardiovascular mortality and morbidity in dialysis patients, was found to be significantly associated with malnutrition. We found higher rates of valvular calcification in patients with vascular calcification. Malnutrition was more prominent in these patients.
{"title":"Son dönem renal yetmezlikli hastalarda vasküler kalsifikasyon, ateroskleroz ve inflamasyon ilişkisi","authors":"Ruya Mutluay, Çiğdem Mengüş, Neslihan Tezcan, Emel ISIKTAS SAYILAR, Ulver Deri̇ci̇, Ceyla KONCA DEĞERTEKİN, Serap Gülteki̇n, Sevim Gönen, Gülten Taçoy","doi":"10.31362/patd.1274511","DOIUrl":"https://doi.org/10.31362/patd.1274511","url":null,"abstract":"Introduction: This study aims to determine the relationship between vascular calcification, carotid artery intima-media thickness (CIMT) and malnutrition with inflammatory parameters in dialysis patients. \u0000Materials and Methods: 140 CKD patients and 44 healthy controls were included in the study. CIMT was measured by ultrasonography. Valvular calcification was assessed by echocardiography and vascular calcification scores (VCS) were done based on the radiograms. Biochemical parameters were assessed using routine laboratory methods. Subjective global assessment (SGA) was used to evaluate malnutrition. \u0000Results: In the study, VCS showed no differences between hemodialysis (HD) and peritoneal dialysis (PD) patients (1.84±2.35 for HD, 1.77±1.64 for PD; p:0.83). CIMT, Osteopontin (OPN), interleukin-6 (IL-6) and homocysteine were significantly different in both dialysis groups compared to healthy controls. The Mean carotid intima-media thickness (m-CIMT) was higher in HD patients compared to PD group. CIMT, vascular calcification and SGA scores showed positive correlation with age, dialysis duration and valvular calcification grades, and negative correlation with albumin levels. A positive correlation between SGA scores and high-sensitive C-reactive protein (hs-CRP) levels was also noted. On multiple regression analysis, m-CIMT was independently associated with age, VCS and albumin levels. VCS was found to be independently associated with only albumin levels. \u0000Conclusion: Vascular and valvular calcification, an indicator of cardiovascular mortality and morbidity in dialysis patients, was found to be significantly associated with malnutrition. We found higher rates of valvular calcification in patients with vascular calcification. Malnutrition was more prominent in these patients.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83046637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Traumatic knee dislocations are a serious injury that threatens the entire extremity, requiring urgent evaluation and a multidisciplinary approach. The high frequency of limb-threatening vascular injury, misdiagnosis of knee injury, or failure to assess the limb's vascular status will result in a large number of potentially preventable amputations. We tried to demonstrate with case examples that this situation should be investigated carefully and aggressive treatment is mandatory in our study. 8 patients who applied to Pamukkale University Orthopedics and Traumatology Clinic and Alaşehir State Hospital Orthopedics and Traumatology Clinic in the last 3 years due to traumatic knee dislocation were evaluated. It was revealed that the group with multiple ligament injuries and neurovascular injuries, which is in the subgroup according to the Schenck classification, was the worst injury group according to the postoperative evaluation tests. It has been shown that postoperative Lysholm and Cincinnati scores of patients in the KD II group with isolated cruciate ligament injury without collateral ligament injury were better than other injuries.Among the patients in the KD I group, it was shown that the postoperative Lysholm and Cincinnati scores were relatively better in the group with anterior cruciate ligament (ACL) injury compared to the group with posterior cruciate ligament (PCL) injury.Management of these serious injuries, the importance of post-operative rehabilitation comes to the forefront with the early and appropriate intervention of experienced orthopedic surgeons with a multidisciplinary approach, as well as the high awareness in terms of neurovascular injuries.
{"title":"Travmatik Diz Çıkıkları","authors":"Mert Bektaş, Harun Güngör, Kadir Gem","doi":"10.31362/patd.1265253","DOIUrl":"https://doi.org/10.31362/patd.1265253","url":null,"abstract":"Traumatic knee dislocations are a serious injury that threatens the entire extremity, requiring urgent evaluation and a multidisciplinary approach. The high frequency of limb-threatening vascular injury, misdiagnosis of knee injury, or failure to assess the limb's vascular status will result in a large number of potentially preventable amputations. We tried to demonstrate with case examples that this situation should be investigated carefully and aggressive treatment is mandatory in our study. 8 patients who applied to Pamukkale University Orthopedics and Traumatology Clinic and Alaşehir State Hospital Orthopedics and Traumatology Clinic in the last 3 years due to traumatic knee dislocation were evaluated. It was revealed that the group with multiple ligament injuries and neurovascular injuries, which is in the subgroup according to the Schenck classification, was the worst injury group according to the postoperative evaluation tests. It has been shown that postoperative Lysholm and Cincinnati scores of patients in the KD II group with isolated cruciate ligament injury without collateral ligament injury were better than other injuries.Among the patients in the KD I group, it was shown that the postoperative Lysholm and Cincinnati scores were relatively better in the group with anterior cruciate ligament (ACL) injury compared to the group with posterior cruciate ligament (PCL) injury.Management of these serious injuries, the importance of post-operative rehabilitation comes to the forefront with the early and appropriate intervention of experienced orthopedic surgeons with a multidisciplinary approach, as well as the high awareness in terms of neurovascular injuries.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"129 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75141099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Although the incidence of differentiated thyroid cancer (DTC) is high, mortality is quite low. In low and intermediate risk DTCs, reoperations due to inadequate treatment can increase morbidity, mortality, and costs in patients. In our study, current articles published on this subject were reviewed and evaluated. According to our results, morbidity, mortality and costs increase due to inadequate treatment in DTCs. Therefore, even in low and intermediate risk DTC cases, adequate surgeries such as total or near total thyroidectomy should be performed by high volume endocrine surgeons and moderate TSH suppression should be applied in all cases.
{"title":"The effects of reoperations due to inadequate treatment in differentiated thyroid cancers on morbidity, mortality and costs","authors":"H. Acar, Arkın Akalin","doi":"10.31362/patd.1322477","DOIUrl":"https://doi.org/10.31362/patd.1322477","url":null,"abstract":"Although the incidence of differentiated thyroid cancer (DTC) is high, mortality is quite low. In low and intermediate risk DTCs, reoperations due to inadequate treatment can increase morbidity, mortality, and costs in patients. In our study, current articles published on this subject were reviewed and evaluated. According to our results, morbidity, mortality and costs increase due to inadequate treatment in DTCs. Therefore, even in low and intermediate risk DTC cases, adequate surgeries such as total or near total thyroidectomy should be performed by high volume endocrine surgeons and moderate TSH suppression should be applied in all cases.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74038679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Sungur, Aylin Sungur, F. Can, A. Esen, B. Güngör, Ö. Yıldırımtürk
Abstract Purpose: Data about the association of malnutrition with prognosis in pulmonary arterial hypertension (PAH) is limited. This study aims to evaluate the relationship of Controlling Nutritional Status (CONUT) score with long-term mortality in PAH. Materials and methods: All consecutive patients newly diagnosed with PAH between 2013 and 2020 were evaluated. CONUT score at diagnosis was calculated through total lymphocyte, albumin and total cholesterol levels. Primary outcome was long-term all-cause mortality. Patients were followed up for 62 (31.3-91.5) months. Results: 92 patients (mean age=43.915.7 years, 65.2% women) were included. 37% of the patients had any degree of malnutrition according to CONUT score (2). Patients without malnutrition were significantly more in the low-risk categories of risk stratification tools (44.8% vs 17.6% according to ESC/ERS guideline, p=0.03; 70.7% vs 35.3% and 70.7% vs 32.4% according to REVEAL 2.0 and REVEAL Lite 2, p
目的:关于肺动脉高压(PAH)患者营养不良与预后关系的资料有限。本研究旨在评估控制营养状态(CONUT)评分与PAH患者长期死亡率的关系。材料和方法:对2013 - 2020年间所有连续新诊断为PAH的患者进行评估。通过总淋巴细胞、白蛋白和总胆固醇水平计算诊断时的CONUT评分。主要结局是长期全因死亡率。随访62(31.3 ~ 91.5)个月。结果:纳入92例患者(平均年龄43.915.7岁，女性占65.2%)。根据CONUT评分(±2)，37%的患者存在不同程度的营养不良。无营养不良的患者在风险分层工具的低风险类别中明显更多(根据ESC/ERS指南，44.8% vs 17.6%， p=0.03;70.7% vs 35.3%和70.7% vs 32.4%根据REVEAL 2.0和REVEAL Lite 2, p
{"title":"Relationship between CONUT score and mortality in patients with pulmonary arterial hypertension","authors":"M. Sungur, Aylin Sungur, F. Can, A. Esen, B. Güngör, Ö. Yıldırımtürk","doi":"10.31362/patd.1324430","DOIUrl":"https://doi.org/10.31362/patd.1324430","url":null,"abstract":"Abstract \u0000Purpose: Data about the association of malnutrition with prognosis in pulmonary arterial hypertension (PAH) is limited. This study aims to evaluate the relationship of Controlling Nutritional Status (CONUT) score with long-term mortality in PAH. \u0000Materials and methods: All consecutive patients newly diagnosed with PAH between 2013 and 2020 were evaluated. CONUT score at diagnosis was calculated through total lymphocyte, albumin and total cholesterol levels. Primary outcome was long-term all-cause mortality. Patients were followed up for 62 (31.3-91.5) months. \u0000Results: 92 patients (mean age=43.915.7 years, 65.2% women) were included. 37% of the patients had any degree of malnutrition according to CONUT score (2). Patients without malnutrition were significantly more in the low-risk categories of risk stratification tools (44.8% vs 17.6% according to ESC/ERS guideline, p=0.03; 70.7% vs 35.3% and 70.7% vs 32.4% according to REVEAL 2.0 and REVEAL Lite 2, p","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77397610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Covid-19 virus is a viral disease that is transmitted quickly between people through close contact and droplets. It spread from China to the rest of the world easily and within a few months. The limited information about COVID 19 and the fact that it has changed the life routine has inevitably affected hospitals and many operating room settings, similar to all everywhere and in all departments of countries. The aim of this article is to discuss the use of personal protection methods in our hospital, to examine the virus exposure of our personnel working in the operating room with the current protection methods in the operating room during the pandemic period lasting more than two years, and to examine and evaluate the effects of vaccination on the severity of the disease. Material method: This study was based on prospective data obtained from Pamukkale University Faculty of Medicine operating room staff between March 2020 and 2022 after receiving the approval from the Ethics Committee. The use of personal protection equipment against COVID-19 virus, exposure to the virus, vaccination status, and hospitalization status of healthcare workers in operating rooms, which is an isolated part of the hospital, were evaluated from the first period of the COVID-19 pandemic. At the same time, the the groups was divided into 2 different time periods: before and after vaccination. The use of personal protective equipment, status of having COVID 19 infection, hospitalizations due to the virus, symptoms in case of illness, vaccination status and the number of doses of vaccine were examined. Those who terminated their employment at the hospital during this period were excluded from the study. Results: The findings of the study were obtained through analysis at 2 different time points. Data were collected at 2 different time points as before and after the vaccination of healthcare workers. Demographic data, personal protective equipment use, COVID positivity and negativity and symptoms of 144 participants were analyzed at two different time points. It has been found in many different analyses that women are better protected than men, but also that the protection of anesthesiologists is higher than that of other groups. Hospitalizations were very rare in operating room staff and they did not have severe symptoms. Finally, there was a significant decrease in symptoms and their severity after vaccination. In conclusion, this study revealed the fact that operating rooms are the most important places where precautions should be taken during pandemics. This study aims to shed light on the protection of operating room staff during possible future outbreaks.
{"title":"Covid 19 Pandemisinde Ameliyathane Çalışanı Olarak Kendimizi Nasıl Koruduk: 2 yıllık ameliyathane deneyimi","authors":"Aslı Mete, İlknur Hatice Akbudak, Simay Seri̇n, Hulya Sungurtekin","doi":"10.31362/patd.1318690","DOIUrl":"https://doi.org/10.31362/patd.1318690","url":null,"abstract":"Introduction: Covid-19 virus is a viral disease that is transmitted quickly between people through close contact and droplets. It spread from China to the rest of the world easily and within a few months. The limited information about COVID 19 and the fact that it has changed the life routine has inevitably affected hospitals and many operating room settings, similar to all everywhere and in all departments of countries. The aim of this article is to discuss the use of personal protection methods in our hospital, to examine the virus exposure of our personnel working in the operating room with the current protection methods in the operating room during the pandemic period lasting more than two years, and to examine and evaluate the effects of vaccination on the severity of the disease. \u0000Material method: This study was based on prospective data obtained from Pamukkale University Faculty of Medicine operating room staff between March 2020 and 2022 after receiving the approval from the Ethics Committee. The use of personal protection equipment against COVID-19 virus, exposure to the virus, vaccination status, and hospitalization status of healthcare workers in operating rooms, which is an isolated part of the hospital, were evaluated from the first period of the COVID-19 pandemic. At the same time, the the groups was divided into 2 different time periods: before and after vaccination. The use of personal protective equipment, status of having COVID 19 infection, hospitalizations due to the virus, symptoms in case of illness, vaccination status and the number of doses of vaccine were examined. Those who terminated their employment at the hospital during this period were excluded from the study. \u0000Results: The findings of the study were obtained through analysis at 2 different time points. Data were collected at 2 different time points as before and after the vaccination of healthcare workers. Demographic data, personal protective equipment use, COVID positivity and negativity and symptoms of 144 participants were analyzed at two different time points. It has been found in many different analyses that women are better protected than men, but also that the protection of anesthesiologists is higher than that of other groups. Hospitalizations were very rare in operating room staff and they did not have severe symptoms. Finally, there was a significant decrease in symptoms and their severity after vaccination. \u0000In conclusion, this study revealed the fact that operating rooms are the most important places where precautions should be taken during pandemics. This study aims to shed light on the protection of operating room staff during possible future outbreaks.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"21 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80053314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transesophageal echocardiography (TEE) revealed a free-floating left atrial ball thrombus in a 56-year-old male patient who was taking warfarin for mechanical prosthetic mitral valve and had recently short-term warfarin interruption for noncardiac surgery and bridging with enoxaparin was admitted to an external center for left abdominal pain and after the detection of spleen and renal infarct, the patient was referred to us for further examination. The patient, who was considered to be at high risk for surgical intervention by the cardiac surgeons, was treated with a warfarin regimen and on the 14th day of the treatment, computed tomography (CT) scan showed that the thrombus disappeared. According to this case report, if patients who have a free-floating left atrial ball thrombus are at high risk for surgical intervention, warfarin therapy can be considered as an alternative to surgery.
{"title":"ORAL ANTİKOAGÜLASYON İLE TEDAVİ EDİLEN SERBEST YÜZEN SOL ATRİYAL TOP TROMBÜSÜ","authors":"Harun Akarsu, Asuman Kaftan, Yiğit Davutoğlu, Gürsel Şen","doi":"10.31362/patd.1259424","DOIUrl":"https://doi.org/10.31362/patd.1259424","url":null,"abstract":"Transesophageal echocardiography (TEE) revealed a free-floating left atrial ball thrombus in a 56-year-old male patient who was taking warfarin for mechanical prosthetic mitral valve and had recently short-term warfarin interruption for noncardiac surgery and bridging with enoxaparin was admitted to an external center for left abdominal pain and after the detection of spleen and renal infarct, the patient was referred to us for further examination. The patient, who was considered to be at high risk for surgical intervention by the cardiac surgeons, was treated with a warfarin regimen and on the 14th day of the treatment, computed tomography (CT) scan showed that the thrombus disappeared. According to this case report, if patients who have a free-floating left atrial ball thrombus are at high risk for surgical intervention, warfarin therapy can be considered as an alternative to surgery.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76972521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayşenur Yılmaz, M. Kılınç, Orçin TELLİ ATALAY, M. Meti̇n, E. Uğurlu, H. Şenol, G. ALTINIŞIK ERGUR
Abstract Purpose: This study aimed to evaluate the cough strength in bronchiectasis patients. It also examined the relationship of cough strength with exercise capacity and quality of life. Materials and methods: The study included 24 bronchiectasis patients and 25 healthy individuals. Exercise capacity was evaluated with the 6-min walk test. Peak cough flow was assessed using a peak expiratory flow PEF cough-meter with a mouthpiece (M1). The quality of life was evaluated with Leicester Cough Questionnaire. Results: A significant difference was found between the groups in terms of PEF cough Meter, 6MWT, LCQ quality-of-life total score, and subdimension scores showed significant differences in favor of the control group (P < 0.05). A positive correlation was observed between PEF cough Meter and the following variables: exercise capacity and Leicester total score (r = 0.780, P < 0.000 and r = 0.885, P < 0.000, respectively). Conclusion: This study found that cough strength was lower in bronchiectasis patients compared with healthy individuals. Cough strength could negatively affect exercise capacity and quality of life. Therefore, Cough strength should be added to the evaluation parameters.
摘要目的:探讨支气管扩张患者的咳嗽强度。它还研究了咳嗽强度与运动能力和生活质量的关系。材料与方法:研究对象为24例支气管扩张患者和25例健康人。通过6分钟步行测试评估运动能力。使用呼气峰值流量PEF咳嗽计(M1)评估咳嗽峰值流量。采用莱斯特咳嗽问卷评估患者的生活质量。结果:两组间PEF咳嗽量表、6MWT、LCQ生活质量总分、子维度评分均有显著差异，对照组优于对照组(P < 0.05)。PEF咳嗽仪与运动能力、Leicester总分呈正相关(r = 0.780, P < 0.000; r = 0.885, P < 0.000)。结论:本研究发现支气管扩张患者咳嗽强度低于健康人。咳嗽强度会对运动能力和生活质量产生负面影响。因此，咳嗽强度应加入到评价参数中。
{"title":"Evaluation of cough strength in bronchiectasis","authors":"Ayşenur Yılmaz, M. Kılınç, Orçin TELLİ ATALAY, M. Meti̇n, E. Uğurlu, H. Şenol, G. ALTINIŞIK ERGUR","doi":"10.31362/patd.1292335","DOIUrl":"https://doi.org/10.31362/patd.1292335","url":null,"abstract":"Abstract \u0000Purpose: This study aimed to evaluate the cough strength in bronchiectasis patients. It also examined the relationship of cough strength with exercise capacity and quality of life. \u0000Materials and methods: The study included 24 bronchiectasis patients and 25 healthy individuals. Exercise capacity was evaluated with the 6-min walk test. Peak cough flow was assessed using a peak expiratory flow PEF cough-meter with a mouthpiece (M1). The quality of life was evaluated with Leicester Cough Questionnaire. \u0000Results: A significant difference was found between the groups in terms of PEF cough Meter, 6MWT, LCQ quality-of-life total score, and subdimension scores showed significant differences in favor of the control group (P < 0.05). A positive correlation was observed between PEF cough Meter and the following variables: exercise capacity and Leicester total score (r = 0.780, P < 0.000 and r = 0.885, P < 0.000, respectively). \u0000Conclusion: This study found that cough strength was lower in bronchiectasis patients compared with healthy individuals. Cough strength could negatively affect exercise capacity and quality of life. Therefore, Cough strength should be added to the evaluation parameters.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80519853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Z. Öner, M. Demir, B. Özkan, E. Mete, İ. Kaleli, A. Çalışkan, Ç. Ergin
Purpose: The present study aims to evaluate the existence of anti-neutrophil cytoplasmic antibody (ANCA) in vasculitis and non-vasculitis diseases. Materials and methods: Over five years, the results of 5107 serum samples submitted to the Medical Microbiology Laboratory for ANCA evaluation were retrospectively analyzed. The existence of ANCA was studied using the preparations containing ethanol-fixed and formalin-fixed granulocyte substratum by indirect immunofluorescence (IIF) testing method; and myeloperoxidase (MPO) and Proteinase-3 (PR-3) antigens in ANCA-positive samples were studied with the ELISA method. Results: 422 (8.3%) of the samples were considered ANCA-positive. 62 (19.9%) of the 312 patients diagnosed with vasculitis and 360 (7.5%) of the 4795 patients with non-vasculitis were ANCA-positive. ANCA-positivity was found 16.7% in patients with IgA vasculitis, 18.6% in leukocytoclastic vasculitis, 56.9% in rheumatoid arthritis, 46.9% in systemic lupus erythematosus, 18.6% in interstitial pulmonary disease, 7.7% multiple sclerosis, 10.2% in chronic renal failure, and 5.1% in cerebrovascular accident. Conclusion: In vasculitis cases, ANCA positivity rate was higher than in non-vasculitis diseases. In non-vasculitis diseases, the target antigen MPO-ANCA and PR3-ANCA positivity was rare compared to vasculitis cases. Among ANCA-positive patients, the most common non-vasculitis diseases included connective tissue disease, chronic renal failure and interstitial pulmonary disease.
{"title":"An evaluation of ANCA in vasculitis and non-vasculitis diseases","authors":"S. Z. Öner, M. Demir, B. Özkan, E. Mete, İ. Kaleli, A. Çalışkan, Ç. Ergin","doi":"10.31362/patd.1276753","DOIUrl":"https://doi.org/10.31362/patd.1276753","url":null,"abstract":"Purpose: The present study aims to evaluate the existence of anti-neutrophil cytoplasmic antibody (ANCA) in vasculitis and non-vasculitis diseases. \u0000Materials and methods: Over five years, the results of 5107 serum samples submitted to the Medical Microbiology Laboratory for ANCA evaluation were retrospectively analyzed. The existence of ANCA was studied using the preparations containing ethanol-fixed and formalin-fixed granulocyte substratum by indirect immunofluorescence (IIF) testing method; and myeloperoxidase (MPO) and Proteinase-3 (PR-3) antigens in ANCA-positive samples were studied with the ELISA method. \u0000Results: 422 (8.3%) of the samples were considered ANCA-positive. 62 (19.9%) of the 312 patients diagnosed with vasculitis and 360 (7.5%) of the 4795 patients with non-vasculitis were ANCA-positive. ANCA-positivity was found 16.7% in patients with IgA vasculitis, 18.6% in leukocytoclastic vasculitis, 56.9% in rheumatoid arthritis, 46.9% in systemic lupus erythematosus, 18.6% in interstitial pulmonary disease, 7.7% multiple sclerosis, 10.2% in chronic renal failure, and 5.1% in cerebrovascular accident. \u0000Conclusion: In vasculitis cases, ANCA positivity rate was higher than in non-vasculitis diseases. In non-vasculitis diseases, the target antigen MPO-ANCA and PR3-ANCA positivity was rare compared to vasculitis cases. Among ANCA-positive patients, the most common non-vasculitis diseases included connective tissue disease, chronic renal failure and interstitial pulmonary disease.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88160165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Purpose: Gentamicin is an antibiotic, used to treat infections caused by microorganisms. Endogenous antioxidants are strengthened by using antioxidant protectors against the toxic effects caused by drugs. Rosmarinic acid has antioxidative, anti-inflammatory, antiapoptotic, and antitumoral effects. In our study, we aimed to investigate the protective effect, immunohistochemical changes, oxidative markers, histopathological changes and inflammation related Ifi44 expression of rosmarinic acid against gentamicin induced nephrotoxicity in rats. Materials and methods: In our study, 32 rats randomly divided into four groups. These groups are consisted of control group, gentamicin group received gentamicin 100 mg/kg/day, gentamicin + rosmarinic group acid received gentamicin 100 mg/kg/day and rosmarinic acid 50 mg/kg/day, and rosmarinic acid group received rosmarinic acid 50 mg/kg/day. At the end of the study, histopathological, immunohistochemical, and biochemical changes in kidney tissues evaluated. Results: Rosmarinic acid reduced creatine, urea, blood urea nitrogen, and total oxidative stress in blood serum. The toxic effect of gentamicin caused severe histopathological changes in the kidneys. A slight decrease in histopathological changes observed in the gentamicin + rosmarinic acid group. Antiproliferative Ifi44 expression was higher in the gentamicin group and gentamicin + rosmarinic acid group. Conclusion: As a result of the application of rosmarinic acid, a decrease in oxygen radicals and an increase in antioxidant levels observed. When used in combination with gentamicin and rosmarinic acid, the protective effect of rosmarinic acid was partially observed, but it could not provide full protection.
{"title":"Investigation of the protective effect of rosmarinic acid in rats given high dose gentamicin","authors":"H. Cetin, Deniz Gündüz, H. Aybek","doi":"10.31362/patd.1268311","DOIUrl":"https://doi.org/10.31362/patd.1268311","url":null,"abstract":"Abstract \u0000Purpose: Gentamicin is an antibiotic, used to treat infections caused by microorganisms. Endogenous antioxidants are strengthened by using antioxidant protectors against the toxic effects caused by drugs. Rosmarinic acid has antioxidative, anti-inflammatory, antiapoptotic, and antitumoral effects. In our study, we aimed to investigate the protective effect, immunohistochemical changes, oxidative markers, histopathological changes and inflammation related Ifi44 expression of rosmarinic acid against gentamicin induced nephrotoxicity in rats. \u0000Materials and methods: In our study, 32 rats randomly divided into four groups. These groups are consisted of control group, gentamicin group received gentamicin 100 mg/kg/day, gentamicin + rosmarinic group acid received gentamicin 100 mg/kg/day and rosmarinic acid 50 mg/kg/day, and rosmarinic acid group received rosmarinic acid 50 mg/kg/day. At the end of the study, histopathological, immunohistochemical, and biochemical changes in kidney tissues evaluated. \u0000Results: Rosmarinic acid reduced creatine, urea, blood urea nitrogen, and total oxidative stress in blood serum. The toxic effect of gentamicin caused severe histopathological changes in the kidneys. A slight decrease in histopathological changes observed in the gentamicin + rosmarinic acid group. Antiproliferative Ifi44 expression was higher in the gentamicin group and gentamicin + rosmarinic acid group. \u0000Conclusion: As a result of the application of rosmarinic acid, a decrease in oxygen radicals and an increase in antioxidant levels observed. When used in combination with gentamicin and rosmarinic acid, the protective effect of rosmarinic acid was partially observed, but it could not provide full protection.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90969795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Primary tubal carcinoma is a uncommon tumor of female ganitale system. The clinical approach of primary tubal cancers is similar to primary ovarian cancers. Fallopian tube carcinoma is hard to diagnosed preoperatively because of its uncertain symptoms. Providing optimal cytoreductive surgery is the most important treatment step in ovarian, tubal and peritoneal carcinomas. We report a case of serous tubal intraepithelial carcinoma and appendix metastasis. A 65 years old post-menopausal woman (gravida 4, para 3) submitted to an external hospital with lower abdominal pain and acute abdominal symptoms. Appendectomy was performed on the patient with preliminary diagnosis of appenditis. The pathology result was reported as high grade serous carcinoma infiltration. Staging surgery was performed with the diagnosis of carcinoma. Until the final pathology result, the diagnosis was considered as appendiceal metastasis of serous tubal cancer. Our clinical and surgical approach to the case, which was diagnosed incidentally with an appendectomy specimen and reported as high grade tubal serous carcinoma, is presented as a case study.
{"title":"Apendektomi sonrası tesadüfen teşhis edilen tubal yüksek dereceli seröz karsinom olgu sunumu","authors":"Pelin Höbek, M. Onan","doi":"10.31362/patd.1232920","DOIUrl":"https://doi.org/10.31362/patd.1232920","url":null,"abstract":"Primary tubal carcinoma is a uncommon tumor of female ganitale system. The clinical approach of primary tubal cancers is similar to primary ovarian cancers. Fallopian tube carcinoma is hard to diagnosed preoperatively because of its uncertain symptoms. Providing optimal cytoreductive surgery is the most important treatment step in ovarian, tubal and peritoneal carcinomas. \u0000We report a case of serous tubal intraepithelial carcinoma and appendix metastasis. A 65 years old post-menopausal woman (gravida 4, para 3) submitted to an external hospital with lower abdominal pain and acute abdominal symptoms. Appendectomy was performed on the patient with preliminary diagnosis of appenditis. The pathology result was reported as high grade serous carcinoma infiltration. Staging surgery was performed with the diagnosis of carcinoma. Until the final pathology result, the diagnosis was considered as appendiceal metastasis of serous tubal cancer. Our clinical and surgical approach to the case, which was diagnosed incidentally with an appendectomy specimen and reported as high grade tubal serous carcinoma, is presented as a case study.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79618184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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